Ovine pulmonary adenocarcinoma is a contagious viral disease of sheep that results in pulmonary neoplasia in some animals. The economic impact can be significant: up to 80% of the flock can be lost upon first exposure to the virus, with continuing losses that may be as high as 20% each year in some flocks. Excluding this disease from a flock is difficult, in part because no diagnostic test can detect animals in the preclinical stage. No effective treatment or vaccine is available, and eradication is challenging. Currently, ovine pulmonary adenomatosis exists in most sheep-raising areas of the world, with the exception of New Zealand and Australia. Iceland is the only country to have successfully eradicated this disease.
Contagious Respiratory Tumours Also known as: Jaagsiekte, Pulmonary Adenomatosis and Adenomatosis - Pulmonary There are two neoplastic conditions which result in contagious respiratory tumours (or contagious lung cancer) in small ruminants: Ovine Pulmonary Adenocarcinoma (also known as ODA, She...
Cytological, histological, and immunohistochemical findings of pulmonary carcinomas with basaloid features | John P. Crapanzano; Kristina Loukeris; Alain C. Borczuk; Anjali Saqi | download | BookSC. Download books for free. Find books
BACKGROUND: Ovine pulmonary adenocarcinoma (OPA) is a worldwide contagious bronchioalveolar carcinoma caused by infection of a beta retrovirus in sheep and less in goat. Neoplastic proliferation of type II pneumocytes and clara cells, produce papillary to acinar tumoral pattern with infiltration of macrophages, lymphocytes and plasma cells and interstitial fibrosis tissue. OBJECTIVES: This study was conducted to investigate the patterns of OPA and checking the expression of TTF1. METHODES: A total of 7952 ovine lungs were studied for macroscopic and microscopic pathology examination and so checking TTF1 marker. RESULTS: 25 cases were diagnosed as OPA that based on macroscopic and histopathologic lesions, two different classifications were defined. Tumoral lesions were divided to classic (68%) and atypic (32%) forms of OPA based on growth pattern and progression and two other forms of mucinous (56%) and non-mucinous (44%) of OPA based on histologic characterization of neoplastic secretory cells were
Looking for online definition of sclerosing adenomatosis in the Medical Dictionary? sclerosing adenomatosis explanation free. What is sclerosing adenomatosis? Meaning of sclerosing adenomatosis medical term. What does sclerosing adenomatosis mean?
To use images and associated descriptions contained on this website, please contact the CFSPH.. These images were annotated by Dr. Steve Sorden and Dr. Claire Andreasen and funding was provided by a USDA Higher Education Challenge Grant in collaboration with the Iowa State University Department of Veterinary Pathology, Center for Food Security and Public Health (CFSPH), Armed Forces Institute of Pathology (AFIP), and Plum Island Animal Disease Center (PIADC). ...
Our research objective is to contribute to a comprehensive understanding of the innate immune control of viral infections, and help create novel therapies for viral diseases based on this understanding. Recently, we identified a family of interferon-inducible transmembrane (IFITM) proteins critical to the intrinsic and innate immune control of several highly pathogenic viruses, including SARS coronavirus, influenza A viruses, dengue virus, West Nile virus, Ebola virus, and Marburg viruses. The IFITM protein family has four human paralogs, IFITM1, 2, 3, and 5. As their names indicate, expression of IFITM proteins is strongly induced by both type I and type II interferons. Our studies demonstrated that IFITM proteins restrict viral replication at the early stage of their lifecycles. We also showed that IFITM proteins differentially restrict influenza A viruses and filoviruses. In vivo, IFITM-mediated restriction plays a pivotal role in control of influenza A virus replication. We observed that ...
Leukemoid reaction with pulmonary carcinoma has been a rare observation. Three cases are presented in detail with possible mechanisms contributing to the production of a leukemoid blood picture.
Endothelial cells are believed to play an important role in response to virus infection. Our previous microarray analysis showed that H9N2 virus infection and inactivated viral particle inoculation increased the expression of interferon-inducible transmembrane protein 1 (IFITM1) in human umbilical vein endothelial cells (HUVECs). In present study, we deeply investigated the expression patterns of IFITM1 and IFITM1-mediated antiviral response induced by H9N2 virus infection and inactivated viral particle inoculation in HUVECs. Epithelial cells that are considered target cells of the influenza virus were selected as a reference control. First, we quantified the expression levels of IFITM1 in HUVECs induced by H9N2 virus infection or viral particle inoculation using quantitative real-time PCR and western blot. Second, we observed whether hemagglutinin or neuraminidase affected IFITM1 expression in HUVECs. Finally, we investigated the effect of induced-IFITM1 on the antiviral state in HUVECs by siRNA and
Tumors with a massive inflammatory infiltration are described in several organs. There is agreement about considering the inflammatory infiltration as the hosts immune response to neoplastic cells; such neoplasms indeed have a better prognostic outc
Introduction: Lung adenocarcinoma has a complex variety of different hystopathologic subtypes with distinct epidemiology, pathology and prognosis. Pulmonary adenocarcinoma with enteric differentiation is a rare variant defined as a tumor with more than 50% of colorrectal-like components, immunohistochemistry (IHC) positive for at least one marker of enteric differentiation (CK20, CDX-2 or MUC2) and no evidence of other malignancies. Case Series: Patients were identified in a review of a set of adenocarcinomas, apparently originated in colon, but posteriorly accessed as lung adenocarcinomas. Median age was 57.6 years, were all Caucasian subjects and presented with metastatic disease. The median size were 6.3 cm at the time of diagnosis and all had spiculated shape forms at CT scans. Microscopic description revealed a lepidic (mucinous) adenocarcinoma in all five cases. Immunohistochemistry were positive for CK20 or CDX-2 in all these cases and was negative for CK7 in one patient. Conclusion: The use of
Startup-freezes Runs slow - posted in Virus, Spyware, Malware Removal: To Coachwife6: Thank you for your help.As you requested, here is my statement of problems, and Hijack file (after running AdAware and Spybot):Problems: 1. freezing during start up and/or shutdown2. freezing during scandisk (also during startup) 3. running very slowly4. I also notied AdAware catching bad items in the Restore archive.Logfile of HijackThis v1.98.2Scan saved at 5:42:41 PM, on 12/15/2004Platform: W...
Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Here we show that IFITM proteins restricted infection mediated by the entry glycoproteins (GP1,2) of Marburg and Ebola filoviruses (MARV, EBOV). Consistent with these observations, interferon-β specifically restricted filovirus and IAV entry processes. IFITM proteins also inhibited replication of infectious MARV and EBOV. We observed distinct patterns of IFITM-mediated restriction: compared with IAV, the entry processes of MARV and EBOV were less restricted by IFITM3, but more restricted by IFITM1. Moreover, murine Ifitm5 and 6 did not restrict IAV, but efficiently inhibited filovirus entry. We further demonstrate that replication of infectious SARS coronavirus (SARS-CoV) and entry mediated by the SARS-CoV spike (S) protein are restricted by IFITM proteins. The profile of ...
Solitary breast metastases are rare and mimic primary breast carcinoma. A 60-year-old female with a history of pulmonary adenocarcinoma presented with a solitary left breast lump suspicious for malignancy on breast imaging. Core-needle biopsy disclosed an adenocarcinoma strongly and diffusely...
Gefitinib is superior to carboplatin-paclitaxel as an initial treatment for pulmonary adenocarcinoma among nonsmokers or former light smokers in East Asia. The presence in the tumor of a mutation of the EGFR gene is a strong predictor of a better outcome with gefitinib. (ClinicalTrials.gov number, N …
Ventilation and some sunshine could go a long way to reduce tuberculosis risks in hospitals and prisons, two strongholds of the contagious lung disease, the World Health Organization said.
Apoptosis is an important mechanism of malignant tumor formation and progression. Single nucleotide polymorphisms (SNPs) located within cell death genes may influence cancer risk. We explored the...
Despite having made only one cytoreductive surgery and after of drainage of the ascitic fluid accumulated in the abdominal cavity the animal improved in the first 48 hours after surgery. Within this 48 hours the animal was more active, had eaten some food and tolerated it and had minimal edema in the limbs. Postoperative chemotherapy with doxorubicin (Doxocris 50, LKM, Buenos Aires, Argentina), 30 mg/m2 IV was initiated immediately after surgery. The dog deteriorated 2 weeks after treatment and died. A complete necropsy (excluding the central nervous system) was performed. The right accessory lung lobe was replaced by a large tumor (11 x 6 x 4 cm) previously diagnosed as a papillary pulmonary adenocarcinoma (Fig. 2 B). Due to the large size of the tumor, the CVC was almost completely compressed. The spleen had multiple red-brown nodules (Fig. 1 C) ranging from 0.5 to 1.3 cm in diameter; these splenic masses were histopathologically diagnosed as chronic splenitis (Fig. 2 C). The liver had ...
Causes of high calcium: Hyperparathyroidism − look also for high ionized calcium, measured or calculated. Hyperparathyroidism may coexist with other endocrine tumors (multiple endocrine adenomatosis syndromes). Carcinoma, with or without bone met
Arizona Governor Doug Ducey on Monday ordered the closure of bars, nightclubs, gyms, movie theaters and water parks, joining other Sunbelt states including Florida and Texas in reversing reopenings after a surge in coronavirus cases.
Oh and the idea about the shroom sheep that someone had would be really nice. Maybe nerf it a little bit so that it would not be op. The shroom sheep could be in two different colors. When sheared it will stay a shroom sheep and gives shroom-wool. Either red with white dots or the brown version. If you kill it it will drop shroom meat, a new drop for mooshroms and shroom sheep and maybe some more shroomcreatures. If you add the ability to milk sheep like goats, the shroom sheep cant be milked maybe because of the shroom infection. This way it wouldnt be too op when it would give too much food and instead would be farmed for its unique wool. Maybe add the ability to dye the red shroom-wool, so that you could have blue wool with white dots and so on.. To regrow the shroom-wool a shroom sheep has to eat mycelium like a normal sheep would eat grass.. ...
N Engl J Med. 2009 Aug 19; Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, Yang JJ, Chewaskulyong B, Jiang H, Duffield EL, Watkins CL, Armour AA, Fukuoka MBACKGROUND: Previous, uncontrolled studies have suggested that first-line treatment with gefitinib would be efficacious in selected patients with non-small-cell lung cancer. METHODS: In this phase 3, open-label study, we randomly assigned previously untreated patients in East Asia who had advanced pulmonary adenocarcinoma and who were nonsmokers or former light smokers to receive gefitinib (250 mg per day) (609 patients) or carboplatin (at a dose calculated to produce an area under the curve of 5 or 6 mg per milliliter per minute) plus paclitaxel (200 mg per square meter of body-surface area) (608 patients). The primary end point was progression-free survival. RESULTS: The 12-month rates of progression-free survival were 24.9% with gefitinib and 6.7% with ...
Threeteen patients of lung cancer of center type underwent carinal resections in our department from January 1985 to December 1996. There were 3 patients, T3N2M0 and 10 patients, T4N2M0. Palliative resections were performed for 3 patients and radical resections, for 10 patients. Carinal resection with right pneumonectomy was done in 3 patients, part carinal resection with right pneumonectomy 6 patients, part carinal resection with left pneumonectomy 1 case, and part carinal resection with right sleeve upper and middle lobectomy 3 patients. There were no operative complications and deaths. The 3-year survival rate was 54% and the 5-year survival rates, 30%. One patient has survived for 8 years. The satisfied results of operative therapy were followed when no lymph node metastesis in mediastinum and mass could be resected.
The ileoanal pouch anastomosis is the procedure of choice for ulcerative colitis and familial adenomatosis polyposis, but can be complicated by anastomotic leak. We discuss the presentation, management, and outcome of 141 leaks after the ileoanal pouch anastomosis procedure in 1424 patients, and propose a management algorithm. Using a combination of nonoperative and operative means and tailoring the management to the presentation of the leak, we were able to achieve an 84% success rate in treating pouches complicated by leaks ...
This years group of papers covers an unusually wide range of notably engaging topics important in clinical internal medicine. To select a number for mention is not to slight the remainder: transient cerebral ischemic attacks, pulmonary biopsy, gastroesophageal reflex, bowel infections by anaerobic bacteria, hospital infections, hirsutism, multiple endocrine adenomatosis, obesity, erythrocytosis with normal blood-gas values, angina without coronaryartery disease, management of ischemic heart disease, acute bacterial diarrhea, abdominal angiography. Name and subject indexes for this volume; cumulative indexes for Volumes 14-20. Recommended for all clinical libraries. ...
Wireless Internet is slow - posted in Virus, Spyware, Malware Removal: Our internet service is between 25 and 30 mbs. I used to average between 10 to 15 mbs wireless. The last few days I have been averaging 1 or less. If I plug in directly to the router I see 25+. I swapped out the wireless card with another card I already had and still very slow. My OTL log is below. OTL logfile created on: 9/13/2014 10:12:11 AM -...
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rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control. ...
Keywords: Edible vaccines, microneedles, microparticulates, needle-free delivery, TLRs, vaccine delivery systems, vaccine,therapeutic, vaccines, adjuvant, DNA vaccination, DEC205, CD40, Active Heymann Nephritis (HN), adjuvant delivery system, subunit vaccines, protein conformation and immunogenicity, glycolipids, Anti-vaccine forces, vaccine safety, vaccine effectiveness, public policy, co-infections, HIV, antiretroviral,HIV-1,therapeutic vaccines,therapeutic, vaccines, co-infections, HIV, antiretroviral,HIV-1,therapeutic vaccines,therapeutic, vaccines, Retroviral pseudotype, virus serology, neutralization assays, pandemic preparedness, virus tropism,zoonotic emerging viruses, serological assays,Rabies virus, lyssaviruses, pseudotypes, vaccines, antivirals, sheep, retrovirus, jaagsiekte, ruminant, serology, Feline, retrovirus, rabies, FIV, FeLV, HIV, Retrovirus, Antiretrovirals, susceptiblity, resistance, sheep retrovirus jaagsiekte ruminant serology, Influenza, pseudotypes, pandemic ...
Aims: Osteopontin (OPN) is a matricellular protein involved in tissue remodelling, cell-mediated immunity and malignant transformation. High OPN serum levels predict poor prognosis in non-small cell carcinoma and set patients with malignant pleural mesothelioma (MM) apart from disease-free asbestos-exposed individuals. Yet neither the spectrum of tissue expression nor the signalling pathways of OPN in MM and pulmonary adenocarcinoma have been characterized, although in vitro evidence links OPN to the epidermal growth factor receptor (EGFR) pathway. The aim of this study was to address these deficiencies.. Methods and results: OPN expression was investigated immunohistochemically in 104 adenocarcinomas and 38 MM and correlated with histological features, including tumour type, grade and proliferation and with expression of activated intermediary EGFR signalling pathway molecules p65, p-AKT, p-ERK, p-STAT-3, and of metalloproteinase (MMP)-1, MMP-2 and MMP-9. In MM, OPN expression was widespread ...
682. Hallmark of Lewy Body dementia / List the slow virus infections that cause dementia / Features that distinguish subcortical from cortical ...
HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3 untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines leads message stability and translation. In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high-risk groups such as those with familial adenomatosis polyposis (FAP) or inflammatory bowel disease (IBD). In human specimens, levels of cytoplasmic HuR were increased in colonic epithelial cells from patients with IBD, IBD-cancer, FAP-adenoma, and colorectal cancer, but not in patients with IBD-dysplasia. Intraperitoneal injection of the HuR small-molecule inhibitor MS-444 in AOM/DSS mice, a model of IBD and inflammatory colon cancer, augmented DSS-induced weight loss and increased tumor multiplicity, size, and invasiveness. MS-444 treatment also abrogated tumor cell apoptosis and depleted tumor-associated ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
[email protected] wrote: , , I have recently been diagnosed w/ pulmonary adenocarcinoma of the , bronchoalveolar type ( I believe). The only treatment being discussed by my , physician is chemotherapy (a combination of taxol and carboplatin). The two , doctors I have consulted differed in their opinion regarding how much time , this treatment might offer, but it may only improve the quality of my life for , a matter of months. Obviously, I am interested in what is ongoing as far as , treatment alternatives and/or clinical trials. Have recently contracted w/ , Best Doctors for info re:whos doing the best work w/ this illness, but have , received no reports and been encouraged to investigate clinical trials. \ , , Please forward any relevant information you might have so that my husband and , I can make better informed treatment decisions. , , Thank you, , Eloise Hendryx , , ps I am new to using the Internet and e-mail , ------------------------------------------------------------------------ , ...
I am currently doing research on the alterations of anatomy, physiology, and pharmacology in schizophrenia. I have read in a few recent sources that in addition to the genetic links, there has been a slow virus theory set forward. If anyone can supply me with any (detailed) information regarding this I would be extremely greatful! Scott (Da Wiez) Jensen /\_/\ E-mail:sjensen at cc.weber.edu , O O , Weber State University \ / ,o, V W WW WWW WWW WWWWW SSSSSSS UUU UUU WWW WWW WWWWW SSS SSS UUU UUU WWW WWW WWW W SSS UUU UUU WWW WWW WWW SSS UUU UUU WWW WWW WWW SSS UUU UUU WWWW WWWW WWWW SSS SSS UUU UUU WWWWWWWWWWWWWW SSSSSS UUUUUUUUUU WE THANK YOU FOR YOUR SUPPORT ...
HGF was detected in BALF supernatants from nearly all of the patients with BAC and was related to local production, because fresh alveolar cells, recovered by BAL and cultured for 24 h, expressed HGF mRNA and released significant amounts of HGF protein. By contrast, HGF was never detected in BALF supernatants from healthy controls, whose alveolar cells did not express HGF mRNA or release HGF protein. Initial studies showed that HGF is a stromal-derived factor affecting the proliferation and motility of normal and tumoral epithelial cells, especially in NSCLC (24) . It was also shown that tumor cells were a potential source of HGF in NSCLC (25, 26, 27, 28) . We show, for the first time, that tumor-infiltrating neutrophils are a potential source of HGF in patients with BAC-subtype ADC. Indeed, HGF levels in BALF supernatants correlated with neutrophil numbers in alveolar spaces but not with counts of other inflammatory cells (lymphocytes and macrophages). Second, immunostaining of BALF cytospin ...
A nasal polyp that does not appear gray and opalescent should arouse suspicion, as should a polyp that bleeds spontaneously. A solid-looking hyperemic polyp
rare (usually fatal) brain disease (usually in middle age) caused by an unidentified slow virus; characterized by progressive dementia and gradual loss of muscle control ...