We identified studies that assessed the impact of publication bias in Medline (January 1993 to October 2003) using the search terms publication bias, citation bias, language bias, location bias, reference bias, or multiple publication bias. We also searched the references of a Cochrane review on publication bias.4 We restricted the search to publications that primarily investigated publication bias and whose acceptance therefore might have depended on whether they had found publication bias or not. We retrieved 265 references. Of these, we chose 148 for full examination. Their bibliographies yielded 26 additional papers. We excluded 148 studies because they gave no original data. All remaining 26 were included in the analysis (see bmj.com).. We used a funnel plot to evaluate reports for publication bias. In a funnel plot the effect size is plotted versus a measure of its precision, such as sample size. With increasing sample size, random variations of the effect are smaller. Thus, ...
1. DwanKAltmanDGArnaizJABloomJChanAW 2008 Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS ONE 3 e3081 doi:10.1371/journal.pone.0003081. 2. HopewellSLoudonKClarkeMJOxmanADDickersinK 2009 Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database Syst Rev 2009 MR000006. 3. McGauranNWieselerBKreisJSchülerY-BKölschH 2010 Reporting bias in medical research-a narrative review. Trials 11 37. 4. SterneJAGavaghanDEggerM 2000 Publication and related bias in meta-analysis: power of statistical tests and prevalence in the literature. J Clin Epidemiol 53 1119 1129. 5. TurnerEH 2004 A taxpayer-funded clinical trials registry and results database. PLoS Med 1 e60 doi:10.1371/journal.pmed.0010060. 6. RisingKBacchettiPBeroL 2008 Reporting bias in drug trials submitted to the Food and Drug Administration: review of publication and presentation. PLoS Med 5 e217 doi:10.1371/journal.pmed.0050217. 7. ...
This page discusses the nature and extent of two common problems we see with formal evaluations: selection bias and publication bias.
An adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations. The test statistic is a direct statistical analogue of the popular funnel-graph. The number of component studies in the …
This study aimed to summarize the previously published literature on the role of platelet-to-lymphocyte ratio (PLR) on overall survival (OS) in patients with gastric cancer. We systematically searched PubMed, EmBase, and the Cochrane library to identify eligible studies to review. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using the random-effects model. Sensitivity and subgroup analyses were performed, and publication bias was assessed. A total of 28 studies comprising 15,617 patients with gastric cancer were included in this meta-analysis. The pooled results indicated that elevated PLR was associated with poor OS (HR: 1.37; 95% CI: 1.24-1.51; P | 0.001). A significant publication bias was observed (Egger test, P = 0.036; Begg test, P = 0.017). After adjusting for publication bias using the trim and fill method, an adjusted pooled HR of 1.19 (95% CI: 1.08-1.33; P = 0.001) was observed. Subgroup analyses indicated an elevated PLR in retrospective studies. Studies
Diagnostic studies with poor test performance results that are not published may lead to exaggerated estimates of a tests true sensitivity and specificity in a systematic review. Because there are typically few studies in the categories of clinical impact, unpublished studies showing no benefit by the use of a diagnostic test have even greater potential to cause bias during a review of evidence. Of note, the problem of publication bias in randomized, controlled trials has been extensively studied, and several visual and statistical methods have been proposed to detect and correct for unpublished studies (11). Funnel plots, which assume symmetrical scattering of studies around a common estimate, are popular for assessing publication bias in randomized, controlled trials. However, the appearance of the shape of the funnel plot has been shown to depend on the choices of weight and metric (12). Without adequate empirical assessments, funnel plots are being used in systematic reviews of diagnostic ...
Previously, TP53 codon 72 polymorphisms have been implicated as risk factors for various cancers. A number of studies have conducted on the association of TP53 codon 72 polymorphisms with susceptibility to breast carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the relationship. We conducted a search in the Medline, EMBASE, OVID, Sciencedirect, and Chinese National Knowledge Infrastructure (CNKI) without a language limitation, covering all papers published up to Jan 2009. The associated literature was acquired through deliberate searching and selected based on the established inclusion criteria for publications. A total of seventeen case-control studies, including 12226 cases and 10782 controls, met the included criteria and thus were selected. Ultimately, the relevant data were extracted and further analyzed using systematic meta-analyses. Overall, no associations of TP53 codon 72 polymorphisms with breast carcinoma were observed
Methods: We searched the MEDLINE, EMBASE, Water Resources Abstracts, and TOXNET databases through 2011 for eligible studies. We also searched the China National Knowledge Infrastructure (CNKI) database, because many studies on fluoride neurotoxicity have been published in Chinese journals only. In total, we identified 27 eligible epidemiological studies with high and reference exposures, end points of IQ scores, or related cognitive function measures with means and variances for the two exposure groups. Using random-effects models, we estimated the standardized mean difference between exposed and reference groups across all studies. We conducted sensitivity analyses restricted to studies using the same outcome assessment and having drinking-water fluoride as the only exposure. We performed the Cochran test for heterogeneity between studies, Beggs funnel plot, and Egger test to assess publication bias, and conducted meta-regressions to explore sources of variation in mean differences among the ...
Background: The validity of research synthesis is threatened if published studies comprise a biased selection of all studies that have been conducted. We conducted a meta-analysis to ascertain the strength and consistency of the association between study results and formal publication. Methods: The Cochrane Methodology Register Database, MEDLINE and other electronic bibliographic databases were searched (to May 2009) to identify empirical studies that tracked a cohort of studies and reported the odds of formal publication by study results. Reference lists of retrieved articles were also examined for relevant studies. Odds ratios were used to measure the association between formal publication and significant or positive results. Included studies were separated into subgroups according to starting time of follow-up, and results from individual cohort studies within the subgroups were quantitatively pooled. Results: We identified 12 cohort studies that followed up research from inception, four that ...
In 1989, Gøtzsche found that, among 244 reports of trials comparing non-steroidal anti-inflammatory drugs in rheumatoid arthritis, 44 (18%) were redundant, multiple publications, which overlapped substantially with a previously published article. Twenty trials were published twice, ten trials three times and one trial four times (Gøtzsche 1989). The production of multiple publications from single studies can lead to bias in a number of ways (Huston 1996). Most importantly, studies with significant results are more likely to lead to multiple publications and presentations (Easterbrook 1991), which makes it more likely that they will be located and included in a meta-analysis. It is not always obvious that multiple publications come from a single study, and one set of study participants may be included in an analysis twice. The inclusion of duplicated data may therefore lead to overestimation of intervention effects, as was demonstrated for trials of the efficacy of ondansetron to prevent ...
We study recently developed nonparametric methods for estimating the number of missing studies that might exist in a meta-analysis and the effect that these studies might have had on its outcome. These are simple rank-based data augmentation techniques, which formalize the use of funnel plots. We sh …
Reactions, anyone? (The full article is here.) -Blair Generalization of trim and fill for application in meta-regression Eric D. Weinhandl1, Sue Duval2,* Ar…
In distinction, when theres no publication bias, the impact from the smaller sized studies has no explanation for being skewed to 1 facet why not check here and so a symmetric funnel plot results. This also signifies that if no publication bias is present, there might be no relationship concerning regular error and result measurement.[19] A adverse or good relation amongst typical mistake and influence measurement would imply that more compact reports that located consequences in a single course only have been far more prone to be published and/or to become submitted for publication ...
Five RCTs (n=641 patients) were included in the review. Sample sizes ranged from 45 to 318. Three of the studies were phase III RCTs and two were phase II RCTs. The quality scores were 7 points in two studies, 6 points in two studies and 5 points in one study. There was no significant difference between ICHP and control chemotherapy in objective response rate (OR 1.29, 95% CI 0.87 to 1.93; four RCTs). No evidence of statistical heterogeneity was found (I2=39.9%, p=0.17). No evidence of publication bias was found (funnel plots showed symmetry, Egger test p=0.83).. When compared to control chemotherapy, ICHP was not associated with any improvement in overall survival (HR 0.94, 95% CI 0.80 to 1.10; four RCTs). No evidence of heterogeneity was found (I2=48.7%, p=0.12).. When compared to control chemotherapy, ICHP was associated with a higher incidence of grade 3 and 4 hemoglobin nadir (OR 3.71, 95% CI 2.56 to 5.39; three RCTs) and platelet nadir (OR 4.9, 95% CI 3.15 to 7.63; four RCTs). No effect ...
This week both the Daily Telegraph and the Daily Mail ran stories claiming that switching off street lights could significantly increase the number of road deaths. The stories were based on a paper published in the Cochrane Library, which considered three studies into the connection between road accidents and street lighting. However, it seems that the headlines are a typical example of misinterpretation of statistics.. As David Spiegelhalter, Professor for the Public Understanding of Risk at the University of Cambridge, writes on his website Understanding Uncertainty, the studies suffer from three major flaws: poor data, publication bias, and whats known as regression to the mean. Spiegelhalter points out that the three studies underlying the paper were poor and conducted decades ago, with one dating from as far back as 1948 - not a very good basis for drawing conclusions about todays traffic. The term publication bias refers to the fact that studies which show dramatic results are more ...
This week in the BMJ theres a head-to-head on trials transparency between me and PhRMA, the pharmaceutical industry representative body in the US. My article is here, PhRMAs is here, both articles are open access for one week (since it was press released, thems the rules at the BMJ…) but mine is open access forever, I think, on this link.. The article from PhRMA is remarkable. Firstly, they imply that people like me, who call for all trial results to be reported, also somehow call for the reckless disclosure of individual patients electronic health records online. This is untrue.. More disturbing is PhRMAs suggestion that the problem has already been fixed. For example, John Castellani says that information on clinical trials for potential new medicines is already required by US law to be posted on ClinicalTrials.gov. As I explain in my piece, the best available published evidence on compliance with this law comes from Prayle et al, BMJ 2012: in reality, the legislation here has been ...
These findings suggest a variation or heterogeneity in the strength of the gene-disease association (often expressed in an odds ratio) observed between Chinese and non-Chinese studies. These studies are primarily case-control studies. Many factors may contribute to the variation in the estimate of odds ratio across such studies, such as the genetic make-up of the population studied, the type of patients included, the selection of controls, the quality of the study design, and the quality of the laboratory work. These factors could lead to either over- or under-estimation of the true odds ratio. However, it is difficult to conceive that any single factor, or combination of these factors, could consistently cause the exaggerated odds ratio in Chinese studies in all the topics (gene-disease associations) examined by Pan and colleagues. Selective publication is therefore a very likely and worrying explanation for their findings ...
Summary: Objective: To systematically review the use of Quantitative sensory testing (QST) in pain characterisation (phenotyping) in Osteoarthritis (OA). Methods: Six bibliographic databases (Medline, Embase, Amed, Cinahl, PubMed, Web of Science) were searched to identify studies published before May 2011. Data were extracted based on the primary site of OA, QST modalities, outcome measures and test sites. Standardised mean difference (SMD) and 95% confidence intervals (CIs) were calculated if possible. Publication bias was determined using funnel plot and Eggers test. Heterogeneity was examined using Cochran Q test and I 2 statistic. Random effects model was used to pool the results. Results: Of 41 studies (2281 participants) included, 23 were case control studies, 15 case only studies, two randomised controlled trials, and one uncontrolled trial. The majority of studies examined pressure pain with smaller numbers using electrical and/or thermal stimuli. QST was more often applied to the ...
Next, one can do an Eggers regression take a look at, which exams whether the funnel plot is symmetrical. As stated in advance of: a symmetrical funnel plot is a sign that theres no publication bias, given that the result size and sample dimensions are not dependent. Thirdly, one can do the trim-and-fill strategy, which imputes knowledge In anonymous case the funnel plot is asymmetrical ...
In this chapter we study how the GLM class of models can be applied for the analysis of data in which the response variable is the lifetime of a component or
ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter that localizes to plasma membranes. Recently, a number of studies have investigated the relationship between the C421A polymorphism in ABCG2 and cancer risk in multiple populations and various types of cancers; however, this relationship remains unclear. Therefore, we performed a meta-analysis to further explore this association. The meta-analysis incorporated 10 studies involving a total of 3593 cases and 5875 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated based on the date extracted from the studies to evaluate the strength of association. We also analyzed the heterogeneity and sensitivity of each report and the publication bias of the studies. Overall, our results showed that there appeared to be a significant association between the ABCG2 C421A polymorphism and decreased cancer susceptibility (heterozygote-AC versus CC: OR = 0.759, 95%CI = 0.620-0.930; dominant effects model-AA/AC versus CC:
Downloadable! Meta regression analysis is used to extract the best average from a set of N primary studies of one economic parameter. Three averages of the N-set are discussed: The mean, the PET meta-average and the augmented meta-average. They are affected by control variables that are used in some of the primary studies. They are the POCs, partly omitted controls, of the meta-study. Some POCs are ceteris paribus controls chosen to make results from different data samples comparable. They should differ. Others are model variables. They may be true and should always be included, while others are false and should always be excluded, if only we knew. If POCs are systematically included for their effect on the estimate of the parameter, it gives publication bias. It is corrected by the meta-average. If a POC is randomly included, it gives a bias, which is corrected by the augmented meta-average. With many POCs very many augmentations are possible. The mean of all augmented meta-averages is also the mean of
Follow the style for numbers included in titles as described in , Numbers and Percentages.Educational Programs in US Medical Schools, 2004 2005 Comparison of 2 Methods to Detect Publication Bias in Meta-analyses Skin Reactions in a Subset of Patients With Stage IV Melanoma Treated With T-Lymphocyte Antigen 4 Monoclonal Antibody as a Single Agent If numbers appear at the beginning of a title or subtitle, they and any unit of measure associated with them should be spelled out. Exceptions may be made for years (see also , Numbers and Percentages, Spelling Out Numbers, Beginning a Sentence, Title, Subtitle, or Heading).Primary
Follow the style for numbers included in titles as described in , Numbers and Percentages.Educational Programs in US Medical Schools, 2004 2005 Comparison of 2 Methods to Detect Publication Bias in Meta-analyses Skin Reactions in a Subset of Patients With Stage IV Melanoma Treated With T-Lymphocyte Antigen 4 Monoclonal Antibody as a Single Agent If numbers appear at the beginning of a title or subtitle, they and any unit of measure associated with them should be spelled out. Exceptions may be made for years (see also , Numbers and Percentages, Spelling Out Numbers, Beginning a Sentence, Title, Subtitle, or Heading).Primary Less ...
Just counting those in categories 1 & 2 there are a total of 91 conditions that WHO claims to be treatable by acupuncture. That by merely sticking needles in various points on the skin can treat such a wide range of diseases and conditions is already suspect. So we shouldnt be surprised that the WHO review is rather flawed. According to Singh & Ernst the WHO committed two major errors in their review. First, WHO set the bar too low for clinical trials it admitted as evidence. [T]he WHO had taken into consideration almost every trial ever conducted, because it had set a relatively low quality threshold. And so low quality trials (which are more prone to producing positive findings) skewed the review. Secondly, WHO included a large number of studies from China. This wouldnt be a problem if not for the fact that careful statistical analyses of all the Chinese results ... demonstrate beyond all reasonable doubt that Chinese researchers are guilty of so-called publication bias. We saw the ...
Please note: the link above shows all members and activities since the IDS group has been established (January 2018). Activities of the former MSS and SC groups (until 2017) are not shown here. Full publication list of the IDS group (including the publications of the former MSS and SC groups): ...
Please go to the Statistics Research Associates website for my full publication list and abstracts and to here for downloadable copies of some of my papers.. to home page. ...
Link: Full publication list Selected papers Ma Y, Guo H, Hu L, Pons Martinez P, Moschou PN, Cevik V, Ding P, Duxbury Z, Sarris PF, Jones JDG (2018) Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors. PNAS 115(41):10218-10227. Minina EA, Reza SH, Gutierrez-Beltran E, Elander PH, Bozhkov PV, Moschou PN…
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The main difference is that in PROC NLMIXED you are introducing a random-effect term ($u$) which is specific for each individual (ID). Depending on your data, this can significantly change coefficients. You can try removing the random statement (and $u$ in $ell$ specification) in PROC NLMIXED to see if this is true.. ...
CNKI学术搜索是一个基于海量资源的跨学科、跨语种、跨文献类型的学术资源搜索平台,其资源库涵盖各类学术期刊、论文、报纸、专利、标准、年鉴、工具书等,旨在为国内外研究人员提供全面、权威、系统的知识网络。
CNKI学术搜索是一个基于海量资源的跨学科、跨语种、跨文献类型的学术资源搜索平台,其资源库涵盖各类学术期刊、论文、报纸、专利、标准、年鉴、工具书等,旨在为国内外研究人员提供全面、权威、系统的知识网络。
CNKI学术搜索是一个基于海量资源的跨学科、跨语种、跨文献类型的学术资源搜索平台,其资源库涵盖各类学术期刊、论文、报纸、专利、标准、年鉴、工具书等,旨在为国内外研究人员提供全面、权威、系统的知识网络。
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|%=strTitleKey%>--CNKI翻译助手:覆盖专业领域最全面的科技术语英汉/汉英辞典,文献、术语中英互译的好帮手,词汇句子段落应有尽有。--中国知网-中文学术资源门户
CNKI远见搜索,是中国知网(CNKI)旗下的专业学术搜索平台,资源囊括了期刊、博士论文、硕士论文、工具书、专利、标准、学术图片、科技成果、知网书等资源,提高一框式快捷搜索与高级搜索等专业检索功能,提供在线阅读与下载服务。
Function to examine publication bias. For both fixed- and random-effects models, estimates from no-pooling effects model are used as study-specific estimates. For random-effects models, the corresponding fixed-effects models are implemented at background to obtain pooled estimate. For example, if users call bmeta to run random-effects meta-analysis with normal prior, fixed-effects meta-analysis with normal prior are implemented at background to obtain pooled estimate for graphing. In the absence of publication and heterogeneity, the scatter resembles a symmetrical funnel and the triangle area formed by connecting the centred summary estimate with its 2.5% and 97.5% quantiles on either side includes about 95% of the studies if the fixed-effects model assumption holds (i.e. all the studies estimate the same effect).
publication bias answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
A prerequisite of evidence based healthcare is that medical interventions are analysed in clinical trials and the findings from these trials are used to inform decision making in the healthcare system. The selective publication of clinical trials (publication bias) and their outcomes (outcome reporting bias) have been identified as major problems distorting the scientific evidence available. As a result, perception of the effects of healthcare interventions based on published literature is biased towards overestimating benefits and underestimating harms.1 2 3 4 5 This problem of distorted public record is widely prevalent.6. To solve the problem, study registration (disclosure at inception that a study is being conducted) and results registration (posting of results after a study has been completed) have been partly implemented using publicly accessible databases. Usually, the details provided at inception and after completion both include information on study methods.. Initiatives to promote ...
Downloadable! Meta-regression models are increasingly utilized to integrate empirical results across studies while controlling for the potential threats of data-mining and publication bias. We propose extended meta-regression models and evaluate their performance in identifying genuine em- pirical effects by means of a comprehensive simulation study for various scenarios that are prevalent in empirical economics. We can show that the meta-regression models here pro- posed systematically outperform the prior gold standard of meta-regression analysis of re- gression coefficients. Most meta-regression models are robust to the presence of publication bias, but data-mining bias leads to seriously inflated type I errors and has to be addressed explicitly.
Robert Clarke and colleagues conduct a meta-analysis of unpublished datasets to examine the causal relationship between elevation of homocysteine levels in the blood and the risk of coronary heart disease. Their data suggest that an increase in homocysteine levels is not likely to result in an increase in risk of coronary heart disease.
TY - JOUR. T1 - P53 abnormalities and outcomes in colorectal cancer: a systematic review. AU - Munro, A. J.. AU - Lain, S.. AU - Lane, D. P.. N1 - dc.publisher: Nature Publishing Group PY - 2005/2. Y1 - 2005/2. N2 - We performed a systematic review of studies that investigated the effect of abnormalities of the tumour suppressor gene p53 upon prognosis in patients with colorectal cancer. The methods used to assess p53 status were immunohistochemistry (IHC), indicating abnormal accumulation of p53, and sequence analysis, indicating presence of p53 mutations (mut). We identified 168 reports, with 241 comparisons of relevant end points and survival data on 18766 patients. We found evidence of both publication bias and heterogeneity of results. Our analysis was hampered by variability in both the assessment of p53 status and the reporting of results. We used a trim and fill method to correct for publication bias and minimised heterogeneity by using well-defined clinical subgroups for the assessment ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A Tandem Process for analyzing publication bias has long been recommended for slicing down Wrong beneficial mistake complications.[20] This Tandem strategy is made up of a few stages. First of all, a single calculates Orwins fall short-Secure N, to examine what number of scientific tests ought to be added as a way to reduce the check statistic to your trivial dimension. If this amount of scientific tests is bigger than the volume of research Employed in the meta-analysis, it is a sign that theres no publication bias, as in that case, one demands loads of experiments to decrease the effect size ...
RESULTS A total of 19 observational studies with 296,439 individuals (30.1% with NAFLD) and nearly 16,000 cases of incident diabetes over a median of 5 years were included in the final analysis. Patients with NAFLD had a greater risk of incident diabetes than those without NAFLD (random-effects hazard ratio [HR] 2.22, 95% CI 1.84-2.60; I2 = 79.2%). Patients with more severe NAFLD were also more likely to develop incident diabetes; this risk increased across the ultrasonographic scores of steatosis (n = 3 studies), but it appeared to be even greater among NAFLD patients with advanced high NAFLD fibrosis score (n = 1 study; random-effects HR 4.74, 95% CI 3.54-5.94). Sensitivity analyses did not alter these findings. Funnel plot and Egger test did not reveal significant publication bias. Study limitations included high heterogeneity, varying degrees of confounder adjustment across individual studies, and lack of studies using liver biopsy ...
For the primary (dichotomous) outcome, relative risks (RRs) and 95% CI were computed using random-effects models (11). The weighted MD and corresponding 95% CI were computed using random-effects models for continuous variables. Between-studies heterogeneity was assessed using the Cochran Q test (based on the pooled RR by Mantel-Haenszel), as well as by measuring inconsistency (I2 [the percentage of total variance across studies attributable to heterogeneity rather than chance]) of treatment effects across trials (12). We used Beggs funnel plot to assess for publication bias for the primary outcome of all-cause mortality (13). Quality assessment of the analyzed RCTs was performed by Jadads method (14). Since the majority of included studies (13 of 14 treatment arms) had a quality score of 4/4 for mortality, suggesting high quality, a formal quality score and/or weighting of results was not calculated. For exercise capacity, only 1 study had nonblinded assessment of outcome. As a number of ...
It has been reported that microRNA-206(miR-206) plays an important role in cancers and could be used as a prognostic biomarker. However, the results are controversial. Therefore, we summarize all available evidence and present a meta-analysis to estimate the prognostic value of miR-206 in various cancers. The relevant studies were collected by searching PubMed, EMBASE, and Web of Science databases until August 21, 2020. Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were applied to explore the association between miR-206 and survival results and clinicopathologic features. Sources of heterogeneity were investigated by subgroup analysis and sensitivity analysis. Publication bias was evaluated using Eggers test. Twenty articles involving 2095 patients were included in the meta-analysis. The pooled HR showed that low miR-206 expression was significantly associated with unfavourable overall survival (OS) (|span class=inline_break||svg xmlns:xlink=http://www.w3.org/1999
Because of its analgesic properties and lack of gastrointestinal side effects, paracetamol has long been seen as a relatively safe medication for the relief of fever and mild to moderate pain in children. Recently, however, ibuprofen has emerged as an alternative. With choice, questions invariably arise as to which drug is superior. Existing findings on the effectiveness and safety of these drugs in adults cannot be generalised to children. Thus, the meta-analysis by Perrott et al is of particular interest. The authors searched for relevant studies using numerous data sources, included only studies with randomised blinded designs, and verified the reliability of independently coded outcome measures with appropriate statistics. The authors stated that no unpublished studies were identified by hand searches, contact with pharmaceutical companies, or a posting on an international listserv. Nonetheless, the possibility exists that a publication bias of unknown size and direction may be ...
Cell-assisted lipotransfer is a novel technique for fat grafting. This study aimed to investigate the clinical efficacy of cell-assisted lipotransfer technology compared with conventional fat grafting. According to PRISMA guidelines, related articles in PubMed, Embase and Cochrane library were systematically searched. Studies focusing on fat survival rate and/or patient satisfaction rate for fat grafting alone versus cell-assisted lipotransfer were retrieved. Estimated fat survival and patient satisfaction rates were pooled. Subgroup analysis was stratified by the transplant site. Publication bias was conducted. Furthermore, the stability of results was assessed by sensitivity analysis. Nine articles were included in the meta-analysis. Significant heterogeneity was observed among individual studies for fat survival rate assessment (I 2 = 98.3%, P | 0.001). The fat survival rate was significantly higher in the cell-assisted lipotransfer group than in the control group [weighted
The Department of Justice announced a series of indictments Tuesday morning against Chinese nationals who have been trafficking fentanyl, the potent drug at the center of the opioid crisis, into
Use of NIV decreased the risk of mortality by 46% (risk ratio (RR) 0.54, 95% confidence interval (CI) 0.38 to 0.76; N = 12 studies; number needed to treat for an additional beneficial outcome (NNTB) 12, 95% CI 9 to 23) and decreased the risk of needing endotracheal intubation by 65% (RR 0.36, 95% CI 0.28 to 0.46; N = 17 studies; NNTB 5, 95% CI 5 to 6). We graded both outcomes as moderate quality owing to uncertainty regarding risk of bias for several studies. Inspection of the funnel plot related to need for endotracheal intubation raised the possibility of some publication bias pertaining to this outcome. NIV use was also associated with reduced length of hospital stay (mean difference (MD) -3.39 days, 95% CI -5.93 to -0.85; N = 10 studies), reduced incidence of complications (unrelated to NIV) (RR 0.26, 95% CI 0.13 to 0.53; N = 2 studies), and improvement in pH (MD 0.05, 95% CI 0.02 to 0.07; N = 8 studies) and in partial pressure of oxygen (PaO2) (MD 7.47 mmHg, 95% CI 0.78 to 14.16 mmHg; N = ...
As far as I am concerned, discussions around the pros and cons of various methods are perfectly fine, esp. if they are directly linked to implementations in R. So, we are considering two methods: 1) A random-effects model with the standard 1/(vi + tau^2) weights (where vi is the sampling variance of the ith study and tau^2 the (estimated) amount of variance/heterogeneity in the true outcomes) versus 2) A random-effects model with 1/vi weights. Under the assumptions of the RE model and in the absence of publication bias, both approaches provide an unbiased estimate of the average true outcome. Approach 1 is more efficient; in fact, using 1/(vi + tau^2) weights gives us the uniformly minimum variance unbiased estimator (UMVUE). Sidenote: To be precise, that is only true if tau^2 would be a known quantity and not estimated (and similarly, the sampling variances must be known quantities). So, really, we are only getting an approximation to the UMVUE. The larger k (number of studies) is, the more ...
Research groupsGene regulation and morphogenesis Molecular embryology Dr Jaime Carvajal. CSICPrincipal Investigator ..
Software technical specs for: data entry, structure, computations options, data import, special purpose analyses, high-resolution plots, publication bias.
Big Pharma Plays Hide-the-Ball With Data But if Tamiflu does nothing, and there s even a slight chance of life-threatening side effects, why was it approved? And why continue to prescribe it? That s what the Cochrane Collaboration argued in a report it published in April. http://www.newsweek.com/2014/11/21/medical-science-has-data-problem-284066.html The most infamous case of publication bias is a 1980 study in which heart attack patients were split into two groups: One group received a drug called lorcainide, while the other group received a placebo. Researchers wanted to ...
Fig. 6. How P value selection from underpowered studies and publication bias conspire to overestimate effect size. The simulations draw random data from a Gaussian (normal) distribution. For controls, the theoretical mean is 4.0. For treated, the theoretical mean is 5.0. So, the true difference between population means is 1.0. The S.D. of both populations was set to 1.0 for the simulations in (A) and was set to 0.5 for those in (B). For each simulation, five replicates were randomly drawn for each population, an unpaired t test was run, and both the difference between means and the two-sided P value were tabulated. Each panel shows the results of 1000 simulated experiments. The left half of each panel shows the difference between means for all the simulated experiments. Half the simulated experiments have a difference greater than 1.0 (the simulated population difference), and half have a difference smaller than 1.0. There is more variation in (A) because the S.D. was higher. There are no ...
Decades spent studying peer review, publication bias, and more have challenged the status quo, but journalologists say they have a long way to go ...
|p|Research design can be daunting for all types of researchers. At its heart it might be described as a formalized approach toward problem solving, thinking, a
Commissioners opinions (or views) explain the basis for their determinations in global and special safeguard investigations and reviews. The Commissioners opinions are contained in publications consisting of the Commissions determination, views, and staff report. Confidential business information has been deleted from the publications. The entire USITC publication is available for the investigations and reviews listed below.
Editor: See notation at the end of this article, including updates, regarding additional article on this site.]. For several years weve been hearing about a form of lifting called super slow, where each repetition is performed slowly (up 10 second, pause, down five seconds, for example). The basic concept - to place greater demand on the muscles by eliminating momentum - is not new. The difference is the extreme slowness of the reps and the claims by some that this is the best (and safest) way to train for size and strength - and some would even add aerobic fitness.. Until now, I havent written about this subject, because there is no research published in peer reviewed journals comparing the efficacy of slow and fast lifting. (One unpublished study reported a 27 pound strength increase for slow training compared to 22 pounds for regular speed.) Frankly, lifting very slowly has never appealed to me. It sounds like a very hard and unpleasant way to train. Anything I wrote would simply be my ...
Your gift will help the University provide a learning environment that is inspiring, innovative and progressive. The right infrastructure and facilities empower our students, faculty and staff to maximise their potential and provide them with essential support to become a world-class university. ...
Roxana Carare Publications. Past and present publications by the Carare Group and collaborators. New publications for 2017 added.
Petaka™ Cell Culturing System Customer Publications. Publications using our Media, Cell Culturing Products, and FBS. Customer Publications. Resources. Neuromics
UN-Waters publications can be divided into two main groups: the publications that represent all Members and Partners of UN-Water - the collective products - and the publications that are under the UN-Water umbrella but produced by groups or individual UN-Water Members and/or Partners - the related products.. ...
In proteins, solvent accessibility of individual residues is a factor contributing to their importance for protein function and stability. Hence one might wish ...
Publications produced with the help of the CISM infrastructure in 2019 in 2018 in 2017 in 2016 in 2015 in 2014 in 2013 Aknowledgements Every year, we ask you to provide your references list of publications in which scientific results have been obtained through the use of equipments and resources of the UCL High Performance Computing group. This small work is useful for you and
Emile Egger & Cie SA , Route de Neuchâtel 36 , 2088 Cressier NE , Tel +41 (0)32 758 71 11 , Fax +41 (0)32 757 22 90 , [email protected] ...
In addition to maintaining the most robust Resource of nonhuman primate reagents, the community of scientific researchers depend on your published research to validate and guide future use of the reagents. We continue to grow the publication database so that peer-reviewed results can inform future research decisions. If you have recently published a study using an NHPRR reagent, you can now add it directly to the publication database.. ...
Included in this category are healthcare electronic or print publications, manuals and related media. The publications listed here must offer reliable medical information and articles related to healthcare which are of interest to the medical professional and/or consumer.
MetaSystems products have been featured in many publications. This page lists only a few. Use the filter tools to find publications that match your interest.
The list contains publications by the group since it was first established in 2012. For individual publication lists, please refer to the our respective personal sites ...
by Roberto and Elio | As this past year came to a close we wanted to get a collection of salient publications to share with our STC audience. To assemble this collection, we asked a number of our friends and colleagues from many locations across the globe to select a publication from 2017 that they found particularly fascinating. Along with...
You will find products that help with acne and acne prone skin. We work well with many different ethnicities and types of skin. Whether you have active acne or acne spots we can help rid those. We are the finest online destination for all your skincare needs.
You might have heard a lot of buzz about One Funnel Away Challenge or some people call it Russell Brunsons One Funnel Away Challenge, ofa challenge or ClickFunnels® 30 Days Virtual Summit etc. Right? But youre still wondering what is this « One funnel away challenge » ? Or is it worth it ? Let me give you my personal One Funnel Away Challenge Review ... Read More
Our staff are active in their fields and regularly publish their research findings for peers. View the publications from our researchers.
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有床義歯学会(JPDA)では英語などの外国語も対応の勉強会・研究会です。English Publicationとして世界に日本の有床義歯を広めて、患者様にとってよりよい入れ歯・義歯の提供のために勉強をしています。
Namo Buddha Publications The Sutra of the Medicine Buddha translated by Thanh (PDF) [BPM300] - Al the various Medicine Buddha Practices are based on this Sutra which has been translated into English by Mimh Thanh. Since he offered this translation for free, we also are honored to offer it for no cost.
OptiStem began work in March 2009. We will post details of publications arising from our research on this page. Search the list by entering your search term(s) into one or more of the boxes below.
OptiStem began work in March 2009. We will post details of publications arising from our research on this page.. Search the list by entering your search term(s) into one or more of the boxes below.. ...