First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study we adopt complementary methods of assessing the structural integrity of grey matter in FEP patients and assess whether these relate to patient clinical and functional outcome at 3year follow-up. 1.5Tesla T1-weighted Magnetic Resonance (MR) images were acquired for 46 patients experiencing their first episode of psychosis and 46 healthy controls. Cerebral cortical thickness and local gyrification index (LGI) were investigated using FreeSurfer software. Volume and shape of the hippocampus, caudate and lateral ventricles were assessed using manual tracing and spherical harmonics applied for shape description. A cluster of cortical thinning was identified in FEP compared to controls; ...
Correction: Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study (vol 9, 20, 2019) : Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study (Translational Psychiatry, (2019), 9, 1, (20), 10.1038/s41398-018-0366-5 ...
Second-trimester exposure to the 1957 A2 influenza pandemic is a controversial risk factor for schizophrenia. Two earlier studies of the Dutch psychiatric registry failed to find an increased risk for exposed subjects, but diagnostic misclassification within the spectrum of non-affective psychoses has not yet been ruled out as an explanation...
Schizophrenia Spectrum and Other Psychotic Disorder: DSM-5® Selections is crafted around a specific disorder cited in DSM-5®. This selection provides a comprehensive overview of the process of diagnosing schizophrenia spectrum and other psychotic disorders while serving as a reference guide to assist in the diagnosis of individual patients. The disorder-specific resource is an invaluable addition to the DSM-5® collection and an important contribution to the mental health profession.. This book contains the critical disorder-specific content from these four titles: ...
To investigate whether low-dose lithium is an effective agent in indicated prevention amongst subjects at ultra-high risk of developing a psychotic disorder. This aim will be achieved by treating a high-risk patient population with low-dose lithium (450mg/day) and investigating its effects using clinical, neuropsychological, neuroimaging and cell biological approaches. We will recruit 30 patients considered to be at ultra-high risk of developing a first psychotic episode, currently receiving treatment at the Personal Assessment and Crisis Evaluation (PACE) clinic in Melbourne, Australia. PACE criteria for identifying patients at high risk include subjects with a family history of psychosis and a decrease in functioning (30% GAF) AND/OR attenuated psychotic symptoms AND/OR brief psychotic symptoms (BLIPS) resolving without treatment. Patients who give informed consent will receive treatment with a slow release form of low dose lithium for a period of a year, plus supportive therapy. Patients who ...
During childhood and adolescence, a change in residence is likely initiated by guardians. Our results could be explained in that the breakup of social networks when moving disrupts the developing ability to make new friends and maintain friendships. This could lead to increased social isolation, which again makes one vulnerable to mental illness including psychotic disorders. However, past 20 years old, moving is likely a personal choice by the individual. We found that longer distances moved predicted a lower likelihood of being diagnosed with a non-affective psychotic disorder past 20 years old. This could be explained by the fact that the personal choice made reflects health and independence as the individual moves out from their parents house and enters work or attends university. Meanwhile, it would be more difficult for individuals vulnerable to non-affective psychotic disorders to move out and enter work or university, due to symptoms revolved around cognitive deficits as well as the ...
TY - JOUR. T1 - . Cognitive alterations in patients with non-affective psychotic disorder and their unaffected siblings and parents. AU - Meijer, J.H.. AU - Simons, C.J.P.. AU - Quee, P.J.. AU - Verweij, K.. PY - 2012. Y1 - 2012. N2 - Objective: The purpose of this study was to examine a range of cognitive measures as candidate phenotypic liability markers for psychosis in a uniquely large sample of patients with psychosis, their unaffected relatives and control subjects. Method: Patients with non-affective psychosis (n=1093), their unaffected siblings (n=1044), parents (n=911), and controls (n=587) completed a comprehensive cognitive test battery. Cognitive functioning was compared using tests of verbal learning and memory, attention/vigilance, working memory, processing speed, reasoning and problem solving, acquired knowledge, and social cognition. Age- and gender-adjusted z-scores were compared between groups using mixed-model analyses of covariance. Clinically relevant impairment (-1 and -2 ...
This study aimed to assess the neurophysiological effects of acute atypical antipsychotic treatment on cognitive functioning in subjects presenting with a first episode of psychosis. We used functional MRI to examine the modulatory effects of acute psychopharmacological intervention on brain activation during four different cognitive tasks: overt verbal fluency, random movement generation, n-back and a spatial object memory task. Treatment with atypical antipsychotics was associated with alterations in regional activation during each task and also when task demands were manipulated within paradigms. The initial treatment of psychosis with atypical antipsychotics thus appears to be associated with modifications of the neurofunctional correlates of executive and mnemonic functions. These effects need to be considered when interpreting group differences in activation between medicated patients and controls.
Schizoaffective disorder is a chronic mental health condition characterized primarily by symptoms of schizophrenia, such as hallucinations or delusions, and symptoms of a mood disorder, such as mania and depression. Because schizoaffective disorder is less well-studied than the other two conditions, many interventions are borrowed from their treatment approaches.. Many people with schizoaffective disorder are often incorrectly diagnosed at first with bipolar disorder or schizophrenia because it shares symptoms of multiple mental health conditions.. Schizoaffective disorder is seen in about 0.3% of the population. Men and women experience schizoaffective disorder at the same rate, but men often develop the illness at an earlier age. Schizoaffective disorder can be managed effectively with medication and therapy. Co-occurring substance use disorders are a serious risk and require integrated treatment.. ...
CANO, Juan F. et al. Prognostic factors for schizophrenia during first psychotic episode. Rev. salud pública [online]. 2007, vol.9, n.3, pp.455-464. ISSN 0124-0064.. Objective Reviewing the available literature regarding prognosis for first psychotic episode for developing schizophrenia. Method A systematic review of studies which have evaluated prognostic determinants for the first psychotic episode and its relationship to schizophrenia was made. Results 161 articles were reviewed which fulfilled the search criteria and which were adjusted to the purpose of the study. Conclusions Duration of untreated psychosis (DUP), pre-morbid functioning level, the presence or predominance of negative symptoms, co-morbid consumption of psychoactive substances and psychosocial state were the most influential characteristics for developing schizophrenia in patients presenting a first psychotic episode.. Keywords : Schizophrenia; psychotic disorder; prognosis; early diagnosis. ...
Depressive symptoms are the strongest predictors of poor QoL/HRQoL in psychotic disorders. Subjective loss of QoL associated with psychotic disorders may be smaller than objective loss of functioning suggests. The EQ-5D is problematic as an outcome measure in psychotic disorders.
TY - JOUR. T1 - Lifetime Prevalence and Correlates of Schizophrenia-Spectrum, Affective, and Other Non-affective Psychotic Disorders in the Chinese Adult Population. AU - Chang, Wing Chung. AU - Wong, Corine Sau Man. AU - Chen, Eric Yu Hai. AU - Lam, Linda Chiu Wa. AU - Chan, Wai Chi. AU - Ng, Roger Man Kin. AU - Hung, Se Fong. AU - Cheung, Eric Fuk Chi. AU - Sham, Pak Chung. AU - Chiu, Helen Fung Kum. AU - Lam, Ming. AU - Lee, Edwin Ho Ming. AU - Chiang, Tin Po. AU - Chan, Lap Kei. AU - Lau, Gary Kar Wai. AU - Lee, Allen Ting Chun. AU - Leung, Grace Tak Yu. AU - Leung, Joey Shuk Yan. AU - Lau, Joseph Tak Fai. AU - van Os, Jim. AU - Lewis, Glyn. AU - Bebbington, Paul. PY - 2017/11. Y1 - 2017/11. KW - epidemiology. KW - population surveys. KW - lifetime prevalence. KW - schizophrenia. KW - affective psychoses. KW - NATIONAL-COMORBIDITY-SURVEY. KW - PSYCHIATRIC-DISORDERS. KW - HONG-KONG. KW - 12-MONTH PREVALENCE. KW - FOLLOW-UP. KW - GENERAL-POPULATION. KW - MENTAL-DISORDERS. KW - GLOBAL ...
TY - JOUR. T1 - Markers of Gluten Sensitivity and Celiac Disease in Recent-Onset Psychosis and Multi-Episode Schizophrenia. AU - Dickerson, Faith. AU - Stallings, Cassie. AU - Origoni, Andrea. AU - Vaughan, Crystal. AU - Khushalani, Sunil. AU - Leister, Flora. AU - Yang, Shuojia. AU - Krivogorsky, Bogdana. AU - Alaedini, Armin. AU - Yolken, Robert. PY - 2010/7/1. Y1 - 2010/7/1. N2 - Background: Increased immune sensitivity to gluten has been reported in schizophrenia. However, studies are inconsistent about this association. Methods: The sample of 471 individuals included 129 with recent-onset psychosis, 191 with multi-episode schizophrenia, and 151 controls. Immunoglobulin (Ig)G and IgA antibodies to gliadin and to tissue transglutaminase, and IgG antibodies to deamidated gliadin were measured. Quantitative levels of antibodies in the psychiatric groups were compared with controls. All participants were categorized as to whether their levels of antibodies met standardized cutoffs for celiac ...
This study is comparing effectiveness of aripiprazole [ABILIFY; LUNDBECK/OTSUKA] and risperidone [RISPERDAL; JANSSEN CILAG] in treating patients with a first
Schizophrenia spectrum and other psychotic disorders https://www.upress.umn.edu/test-division/bibliography/2010-2019/2014/allen_schizophrenia_2014 https://www.upress.umn.edu/logo.png ...
Clinical variables and general demographic variables have little impact on relapse rates. Conversely, non-adherence with medication, persistent substance use disorder, carers criticism and poorer premorbid adjustment significantly increase the risk for relapse in FEP. Future studies need to address …
Background: Little is known about self-harm occurring during the period of untreated first-episode psychosis. Aims: To establish the prevalence, nature, motivation and risk factors for self-harm occurring during the untreated phase of first-episode psychosis. Method: As part of the AESOP (Aetiology and Ethnicity in Schizophrenia and Other Psychoses) study, episodes of self-harm were identified among all incident cases of psychosis presenting to services in south-east London and Nottingham over a 2-year period. Results: Of the 496 participants, 56 (11.3%) had engaged in self-harm between the onset of psychotic symptoms and first presentation to services. The independent correlates of self-harm were: male gender, belonging to social class I/II, depression and a prolonged period of untreated psychosis. increased insight was also associated with risk of self-harm. Conclusions: Self-harm is common during the pre-treatment phase of first-episode psychosis. A unique set of fixed and malleable risk ...
The Schizophrenia International Research Society (SIRS) has awarded its first ever Research Harmonisation Group Award (RHG) to the conveners Wim Veling, M.D., Ph.D. and Craig Morgan, Ph.D. Their proposal will develop a blueprint for cataloguing and harmonizing data from existing first episode psychosis cohorts and identifying a consensus set of measures for such cohorts. It will explore how an international infrastructure can be built for sharing and harmonizing first episode psychosis epidemiology cohort data.. The purpose of an RHG is to produce methods that will allow sharing and/or comparing data across countries to accelerate schizophrenia research internationally. The RHG is expected to harmonise measurement techniques or data sharing that will support funded studies that will boost research outcomes.. If you have questions about the 2020 RHG awardee deliberations, please contact Wim Veling at [email protected] To learn more about the SIRS RHG award, please click here .. ...
Translational Psychiatry explores the more translational area between the research in neuroscience and conceptually novel treatments
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
OBJECTIVES--To determine the accuracy of diagnoses of schizophrenia and non-affective psychosis entered by general practitioners on a computer system. To compare recording of clinical events on computer with written records. DESIGN--Examination of case notes of all patients with a computer diagnosis of psychosis. Search of 8000 randomly selected patient records to identify patients with psychosis not recorded on computer and comparison of 141 computer and written entries for prescribing and consultation in each practice. SETTING--13 London practices on the VAMP research bank. MAIN OUTCOME MEASURES--Accuracy of record of psychosis compared with ICD 9, American Psychiatric Association diagnostic manual, and syndrome checklist criteria. RESULTS--Computer search revealed 102 patients with schizophrenia, 78 with other psychoses, and 71 with non-affective psychosis who had adequate case notes. The sensitivity and positive predictive value of the computer diagnosis of schizophrenia were 88% (95% ...
Description of disease Schizoaffective Disorder. Treatment Schizoaffective Disorder. Symptoms and causes Schizoaffective Disorder Prophylaxis Schizoaffective Disorder
Brief psychotic disorder is a period of psychosis whose duration is generally shorter, is not always non-recurring, but can be, and is not caused by another condition. The disorder is characterized by a sudden onset of psychotic symptoms, which may include delusions, hallucinations, disorganized speech or behavior, or catatonic behavior. The symptoms must not be caused by schizophrenia, schizoaffective disorder, delusional disorder or mania in bipolar disorder. They must also not be caused by a drug (such as amphetamines) or medical condition (such as a brain tumor). The term bouffée délirante describes an acute nonaffective and nonschizophrenic psychotic disorder, which is largely similar to DSM-III-R and DSM-IV brief psychotic and schizophreniform disorders. Symptoms generally last at least a day, but not more than a month, and there is an eventual return to full baseline functioning. It may occur in response to a significant stressor in ones life, or in other situations where a stressor is ...
Background: Lower intelligence quotient (IQ) has frequently been reported in patients with schizophrenia. However, it is unclear whether IQ declines (further) after illness onset and what the familial contribution is to this change. Therefore, we investigate IQ changes during the course of illness in patients with non-affective psychosis, their siblings ... read more and controls. Methods: Data are part of the longitudinal Genetic Risk and Outcome of Psychosis (GROUP) study in the Netherlands and Belgium. Participants underwent three measurements, each approximately 3 years apart. A total of 1022 patients with non-affective psychosis [illness duration: 4.34 (s.d. = 4.50) years], 977 of their siblings, and 565 controls had at least one measure of IQ (estimated from four subtests of the WAIS-III). Results: At baseline, IQ was significantly lower in patients (IQ = 97.8) and siblings (IQ = 108.2; p , 0.0001) than in controls (IQ = 113.0; p , 0.0001), and in patients as compared with siblings (p , ...
Objective: Patients with first-episode psychosis have a high prevalence of tobacco use. We aimed to examine the prevalence and course of tobacco use during early psychosis using meta-analysis.. Data Sources: Systematic search of MEDLINE (1948-2011), Embase (1947-2011), CINAHL (1984-2011), PsycINFO (1967-2011), and ISI Web of Science (1900-2011) using the search terms [psychosis OR schizophrenia] AND [tobacco OR smoking OR nicotine].. Study Selection: We located 10 studies reporting the age at initiation of daily tobacco use and the age at onset of psychosis, 31 studies reporting prevalence of tobacco use in patients with first-episode psychosis, 10 studies comparing smoking to age-/gender-matched controls, and 7 studies reporting prevalence of tobacco use at intervals after treatment.. Data Extraction: The following data were extracted: age at initiation of daily tobacco use and at onset of psychosis, the proportion of patients with first-episode psychosis who used tobacco, the proportion of the ...
Schizophrenia is thought to be a neurodevelopmental disorder with pathophysiological processes beginning in the brain prior to the emergence of clinical symptoms. Recent evidence from neuroimaging studies using techniques such as diffusion tensor imaging has identified white matter abnormalities that are suggestive of disrupted brain myelination and neuronal connectivity. Identifying whether such effects exist in individuals at high risk for developing psychosis may help with prevention and early intervention strategies. In addition, there is preliminary evidence for a role of lipid biology in the onset of psychosis, along with well-established evidence of its role in myelination of white matter tracts. As such, this article synthesises the literature on polyunsaturated fatty acids (PUFAs) in myelination and schizophrenia, hypothesizing that white matter abnormalities may potentially mediate the relationship between PUFAs and schizophrenia. Diffusion tensor imaging studies were identified through a
The heterogeneous group of acute and transient psychotic disorders are characterized by three typical features, listed below in descending order of priority: ♦ suddenness of onset (within 2 weeks or less); ♦ presence of typical syndromes with polymorphic (changing and variable) or schizophrenic symptoms; ♦ presence of associated acute stress (stressful events such as bereavement, job loss, psychological trauma, etc.). The onset of the disorder is manifested by an obvious change to an abnormal psychotic state. This is considered to be abrupt when it occurs within 48 h or less. Abrupt onset often indicates a better outcome. Full recovery occurs within 3 months and often in a shorter time (a few days or weeks). However, a small number of patients develop persistent and disabling states. The general (G) criteria for these acute disorders in DCR-10 (Diagnostic Criteria Research of ICD) are as follows. G1 There is acute onset of delusions, hallucinations, incomprehensible or incoherent speech, or
Eur Child Adolesc Psychiatry. 2010 Sep;19(9):741-2. Epub 2010 Mar 31. Brain germinoma presenting as a first psychotic episode in an adolescent male. Undurraga J, Baeza I, Valentí M, Lázaro ML. Source Department of Psychiatry, Institute of Neuroscience, Hospital Clínic de Barcelona, Servicio de Psiquiatría (Escalera 9, Planta 6), Calle Villarroel, Barcelona, Spain. [email protected] PMID:20354887[PubMed -…
With final diagnoses of bipolar-I (BD-I, n=216), schizoaffective (SzAffD, 71), and major depressive (MDD, 42) disorders, 329 subjects were followed for 4.47 [CI: 4.20-4.47] years. Initial episodes were: mania (41.6%), mixed-states (24.3%), depression (19.5%), or apparent nonaffective psychosis (14.6%). Antecedent morbidity presented 12.7 years before first-episodes (ages: SzAffD≤BD-I,MDD). Long-term %-of-days-ill ranked: SzAffD (83.0%), MDD (57.8%), BD-I (45.0%). Morbidity differed by diagnosis and first-episode types, was predicted by first-episodes, and suggested by antecedent illnesses. Long-term wellness was greater with: BD-I diagnosis, first-episode not mixed or psychotic-nonaffective, rapid-onset, and being older at first antecedents, but not follow-up duration ...
OBJECTIVE: The authors investigated the structural brain correlates of antisaccade performance. METHOD: Magnetic resonance imaging was used to measure the volumes of the prefrontal, premotor, sensorimotor, and occipitoparietal cortices as well as the caudate, thalamus, cerebellar vermis, and cerebrum in 20 first-episode psychosis patients and 18 healthy comparison subjects. Antisaccades were recorded by using infrared oculography. RESULTS: Groups significantly differed in terms of antisaccade error rate and amplitude gain and tended to differ in terms of latency but not brain region volumes. Premotor cortex volume predicted antisaccade error rate among comparison subjects. In the patient group, caudate volume was related to latency and amplitude gain. Negative symptoms, independent of structural volumes, predicted error rate. CONCLUSIONS: These findings point to altered structure-function relationships in first-episode psychosis.. ...
Objective: The aim of this study was to construct a rating scale to predict long-term outcome on the basis of clinical and sociodemographic characteristics in patients with symptoms of psychosis who seek psychiatric help for the first time. Method: Patients (N = 153) experiencing their first episode of psychosis (DSM-IV schizophrenia, schizophreniform disorder, schizoaffective disorder, brief psychotic episode, delusional disorder, affective psychosis with mood-incongruent delusions, or psychotic disorder not otherwise specified or being actively psychotic) were consecutively recruited from 17 psychiatric clinics in Sweden from January 1996 through December 1997 (24 months). Baseline characteristics were assessed with an extensive battery of psychiatric rating scales; duration of untreated psychosis, premorbid characteristics, and cognitive functioning were also assessed. The relationship between baseline characteristics and the 5-year outcome was analyzed using a stepwise logistic regression ...
There remains much to learn about the relationship between psychotic symptoms, neurotic symptoms and psychotic illness; nevertheless, some conclusions are clear. Psychotic symptoms in youths can no longer be regarded as having predictive specificity for subsequent psychotic illness. In the general population they may be innocuous, transitory phenomena or occur alongside a range of other psychopathology. Where there is help-seeking or a need for care, clinicians should view psychotic symptoms in the same way as they view depressive symptoms: psychological states that require assessment but that, in themselves, do not signify any particular diagnosis or any specific course of action. The context is key in determining the treatment.. From the point of view of phenomenology, this view avoids the need to invent distinct entities for individual symptoms that do not fit the most likely or helpful clinical diagnosis. An example is the use of the ambiguous term pseudo-hallucinations in individuals with ...
PubMed journal article Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy control were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad, or Android
BACKGROUND: Clinical outcomes in people identified as at ultra-high risk (UHR) for psychosis are remarkably heterogeneous, and are difficult to predict on the basis of the presenting clinical features. Individuals at UHR are at risk of poor functional outcome regardless of development of psychotic disorder. The aim of the present study was to assess whether there is a relationship between functional neuroimaging measures at presentation and functional outcome as measured by the GAF three years after scanning. METHODS: Functional magnetic resonance imaging (fMRI) data were collected during an object working memory task in 34 ultra-high risk (UHR) subjects and 20 healthy controls. On the basis of their GAF scores at follow up, the UHR participants were divided into subgroups with good and poor functional outcomes, respectively. RESULTS: At baseline, the UHR group differed from controls in showing altered frontal and cuneus/posterior cingulate activation. Significant group x task interactions were found in
Neuropsychological functioning and jumping to conclusions in recent onset psychosis patients Schizophr Res. 2018 May; 195:366-371. . View in PubMed. Neuropsychological functioning and jumping to conclusions in recent onset psychosis patients Schizophr Res. 2018 05; 195:366-371. . View in PubMed. Development and validation of the Questionnaire of Stressful Life Events (QSLE) J Psychiatr Res. 2017 Dec; 95:213-223. . View in PubMed. Predictive capacity of prodromal symptoms in first-episode psychosis of recent onset Early Interv Psychiatry. 2017 Nov 08. . View in PubMed. Randomized control trial to assess the efficacy of metacognitive training compared with a psycho-educational group in people with a recent-onset psychosis Psychol Med. 2017 Jul; 47(9):1573-1584. . View in PubMed. Development and validation of the Questionnaire of Stressful Life Events (QSLE) J Psychiatr Res. 2017 12; 95:213-223. . View in PubMed. Influence of cognition, premorbid adjustment and psychotic symptoms on psycho-social ...
Objective: While the most common causes of late life psychosis are factors other than primary psychosis, but the nosology and clinical features of late life, primary psychotic is a matter of controversy. The goal of this study was to define some correlates and symptoms profile of very late-onset schizophrenia-like psychosis among an Iranian elderly population presenting with psychosis. Method: From 201 psychotic elderly patients, 39 (19.4%) subjects with the most possible diagnosis of very late-onset schizophrenia-like psychosis were selected. Socio demographic characteristics, past psychiatric history, family history of psychiatric problems, personality traits, cognitive status, history of stressful life events, and burden of medical problems assessed and compared between patients and 39 age and sex mathed controls. Results: The mean age of study sample was 76.9 years. Of 39 patients with VLOSLP, 13 (33.3%) were male and 26 (66.6%) were female. In 32 patients (82.05%) some sorts of
Background: Reduced prepulse inhibition (PPI) of the auditory startle reflex is a hallmark feature of attention-processing deficits in patients with schizophrenia and other psychotic disorders. Recent evidence suggests that these deficits may also be present before the onset of psychosis in individuals at ultra-high risk (UHR) and become progressively worse as psychosis develops. We conducted a longitudinal follow-up study to observe the development of PPI over time in UHR adolescents and healthy controls. Methods: Two-year follow-up data of PPI measures were compared between UHR adolescents and a matched control group of typically developing individuals. Results: We included 42 UHR adolescents and 32 matched controls in our study. Compared with controls, UHR individuals showed reduced PPI at both assessments. Clinical improvement in UHR individuals was associated with an increase in PPI parameters. Limitations: A developmental increase in startle magnitude partially confined the interpretation ...
schizophreniform disorder is a type of schizophrenia that lasts for less than six months. like schizophrenia, schizophreniform disorder is a type of
TY - JOUR. T1 - MRI Indices of Cortical Development in Young People with Psychotic Experiences. T2 - Influence of Genetic Risk and Persistence of Symptoms. AU - Fonville, Leon. AU - Drakesmith, Mark. AU - Zammit, Stanley. AU - Lewis, Glyn H. AU - Jones, Derek K.. AU - David, Anthony S.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background: Psychotic experiences (PEs) are considered part of an extended psychosis phenotype and are associated with an elevated risk of developing a psychotic disorder. Risk of transition increases with persistence of PEs, and this is thought to be modulated by genetic and environmental factors. However, it is unclear if persistence is associated with progressive schizophrenia-like disturbances in neuroanatomy.Methods: We examined cortical morphometry in 247 young adults, from a population-based cohort, assessed for the presence of PEs at ages 18 and 20. We then incorporated a polygenic risk score for schizophrenia (PRS) to elucidate the effects of high genetic risk. Finally, ...
OBJECTIVE: Kraepelin considered declining course a hallmark of schizophrenia, but others have suggested that outcomes usually stabilize or improve after treatment initiation. The authors investigated this question in an epidemiologically defined cohort with psychotic disorders followed for 20 years after first hospitalization. METHOD: The Suffolk County Mental Health Project recruited first-admission patients with psychosis from all inpatient units of Suffolk County, New York (response rate, 72%). Participants were assessed in person six times over two decades; 373 completed the 20-year follow-up (68% of survivors); 175 had schizophrenia/schizoaffective disorder. Global Assessment of Functioning (GAF), psychotic symptoms, and mood symptoms were rated at each assessment. Month 6, when nearly all participants were discharged from the index hospitalization, was used as a reference. RESULTS: In the schizophrenia group, mean GAF scores declined from 49 at month 6 to 36 at year 20. Negative and ...
Find out about brief psychotic disorder symptoms (delusions, hallucinations), treatment, and criteria. Brief psychotic disorder is a short-term illness with psychotic symptoms.
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TY - JOUR. T1 - Two subdomains of negative symptoms in psychotic disorders: Established and confirmed in two large cohorts. AU - Liemburg, Edith. AU - Castelein, Stynke. AU - Stewart, Roy E.. AU - van der Gaag, Mark. AU - Aleman, Andre. AU - Genetic Risk and Outcome of Psychosis (GROUP) Investigators. AU - van Os, Jim. AU - Germeys, Inez. AU - Bruggeman, Richard. AU - Linszen, Don. AU - Knegtering, Henderikus. PY - 2013/6. Y1 - 2013/6. KW - Factor analysis. KW - Negative symptoms. KW - Psychotic disorder. KW - Schizophrenia. U2 - 10.1016/j.jpsychires.2013.01.024. DO - 10.1016/j.jpsychires.2013.01.024. M3 - Article. VL - 47. SP - 718. EP - 725. JO - Journal of Psychiatric Research. JF - Journal of Psychiatric Research. SN - 0022-3956. IS - 6. ER - ...
Postpartum psychosis can be induced by hormonal changes after birth and is often reminiscent of schizophrenia or bipolar disorder. It is very rare, occurring only in around one in 500 pregnancies.. A completely different illness can also affect the brain - and thereby cause psychotic symptoms. Goitre, brain tumours, Huntingtons chorea, viral infection and AIDS are all examples of diseases that can have this effect.. Since these diseases normally can be diagnosed with the aid of physical tests, if they are the cause it is quickly apparent. Even so, of course, it may be hard to make a diagnosis, especially in the beginning. However, it is important to find out more about whether there is an underlying disease, since the treatment will the be a different one. If this other disease can be treated, the psychosis will ordinarily disappear.. ...
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This study compared the efficacy of quetiapine versus olanzapine in adolescents with early-onset psychosis. The primary measure of interest was cognitive
Diagnostic assessment of alcohol-induced psychotic disorders and delirium followed the guidelines of DSM-IV: a diagnosis of primary psychotic disorder was given if there was no evidence of heavy substance use or withdrawal, or if the psychotic symptoms were established before heavy substance use, or if the symptoms persisted for more than a month during a substance-free period. Alcohol-induced psychotic disorder was diagnosed only if a primary psychotic disorder had been ruled out. In alcohol-induced psychotic disorder, prominent psychotic symptoms occurred during or shortly after periods of heavy alcohol use. During these periods the psychotic symptoms were in excess of those usually associated with alcohol intoxication or withdrawal with perceptual disturbances, and severe enough to warrant clinical attention. To improve reliability the psychotic symptoms had to last at least 1 day, which is the minimum duration of brief psychotic disorder. The minimum duration of psychotic symptoms in ...
Objective: Numerous studies have found a robust association between cannabis use and the onset of psychosis. Nevertheless, the relationship between cannabis use and the onset of early (or, in retrospect, prodromal) symptoms of psychosis remains unclear. The study focused on investigating the relationship between cannabis use and early and high-risk symptoms in subjects at clinical high risk for psychosis.. Method: Prospective multicenter, naturalistic field study with an 18-month follow-up period in 245 help-seeking individuals clinically at high risk. The Composite International Diagnostic Interview was used to assess their cannabis use. Age at onset of high risk or certain early symptoms was assessed retrospectively with the Interview for the Retrospective Assessment of the Onset of Schizophrenia.. Results: Younger age at onset of cannabis use or a cannabis use disorder was significantly related to younger age at onset of six symptoms (0.33 , rs , 0.83, 0.004 , P , 0.001). Onset of cannabis ...
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Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting [email protected] All previous versions of the manuscript and all author responses to the reviewers are also available.. You can find further information about the peer review system here.. ...
Cannabis is known to produce acute, transient psychotic-like experiences. However, it is unclear whether cannabis disproportionately increases the risk of specific types of psychotic experiences and whether genetic predisposition influences the relationship between cannabis use and psychotic experiences. In this cross-sectional study of 109,308 UK Biobank participants, we examined how schizophrenia polygenic risk modulates the association between self-reported cannabis use and four types of self-reported psychotic experiences (auditory hallucinations, visual hallucinations, persecutory delusions, and delusions of reference). Cohort-wide, we found a strong, dose-dependent relationship between cannabis use and all four types of psychotic experiences, especially persecutory delusions. Cannabis users psychotic experiences tended to be earlier-onset and cause greater distress than non-users, but were not more likely to lead to help-seeking. Participants with high schizophrenia polygenic risk scores showed
Rob Wolf Bruce Neben Ryan Melton http://www.iepa.org.au  Dropping Schizophrenia subtypes    Adding Psychosis Risk Syndromes    Includes shared psychotic disorder Adds catatonia specifier Attenuated Psychotic Symptoms Syndrome Moving away from prodrome. http://www.dsm5.org/Pages/Default.aspx  Aims  Rule out past and current psychosis  POPS (presence of psychotic symptoms at 6 on SOPS- scale of psychosis risk syndromes.  Rule in one or more of 3 types of At risk syndromes  BIPS (Brief Intermittent Psychotic State)  Attenuated Positive Symptom State (APSS)  Genetic Risk & Deterioration (GRD) Rate severity of current at risk syndromes.  Major changes   Rule out criteria emphasized  Emphasis on more objective GAF.    1 year RCT of 10 sites with 1268 individuals (China). Tx group received meds, family psychoeducation (not mfg), skills training, CBT. Outcomes:   Tx group lower drop out Tx group greater improvement in insight, social ...
TY - JOUR. T1 - Decreased BDNF in patients with antipsychotic naïve first episode schizophrenia. AU - Jindal, Ripu D.. AU - Pillai, Anilkumar R. AU - Mahadik, Sahebrao P.. AU - Eklund, Kevin. AU - Montrose, Debra M.. AU - Keshavan, Matcheri S.. PY - 2010/6/1. Y1 - 2010/6/1. N2 - Objective: Brain-derived neurotrophic factor (BDNF) is a key factor known to mediate neuronal proliferation, differentiation, survival and response to stress. Decreases in BDNF levels have been reported in schizophrenia, but studies in treatment naïve patients are few. Herein we report on serum BDNF levels in a series of patients with first-episode treatment naïve psychoses in comparison to age matched healthy controls. Method: Fasting serum BDNF levels were measured in 41 patients with treatment naive first episode psychosis (24 with schizophrenia, schizoaffective disorder or schizophreniform disorder, and 17 with non-schizophrenia psychotic disorders) and 41 age-matched healthy controls. Results: A three group ...
TY - CONF. T1 - Better social but worse academic premorbid adjustment in cannabis-users psychotic patients across Europe. AU - Ferraro, Laura. AU - La Barbera, Daniele. AU - Seminerio, Fabio. AU - Sartorio, Crocettarachele. AU - Capuccio, Veronica. AU - Tripoli, Giada. AU - La Cascia, Caterina. AU - Mulè, Alice. AU - Sideli, Lucia. PY - 2016. Y1 - 2016. N2 - Background: Several studies report that patients with psychosis whoused cannabis have a better cognitive performance than those whodid not (Rabin et al. 2011). In a previous study we found out a higherpremorbid IQ, and a better IQ in psychotic patients who smokedcannabis in their lifetime, and our findings were consistent with theidea that this association is due to a better premorbid functioningrather than to an ameliorative effect of cannabis use on cognitiveperformance (Ferraro et al., 2013). A number of authors havehypothesized that psychotic patients who consume cannabis constitutea differentiated subgroup of patients that have better ...
New life-saving treatments for Schizophrenia | schizoaffective disorder | psychotic disorders | schizophreniform disorder | delusional disorder in clinical trial on Development and Pilot Evaluation of Modified Cognitive Behavioural Therapy for Adolescents With Early Onset Psychosis
Objective Social adversity and urban upbringing increase the risk of psychosis. We tested the hypothesis that these risks may be partly attributable to school mobility and examined the potential pathways linking school mobility to psychotic-like symptoms. Method A community sample of 6,448 mothers and their children born between 1991 and 1992 were assessed for psychosocial adversities (i.e., ethnicity, urbanicity, family adversity) from birth to 2 years, school and residential mobility up to 9 years, and peer difficulties (i.e., bullying involvement and friendship difficulties) at 10 years. Psychotic-like symptoms were assessed at age 12 years using the Psychosis-like Symptoms Interview (PLIKSi). Results In regression analyses, school mobility was significantly associated with definite psychotic-like symptoms (odds ratio [OR] =1.60; 95% CI =1.07-2.38) after controlling for all confounders. Within path analyses, school mobility (probit coefficient [β] = 0.108; p = .039), involvement in bullying ...
STUDY OBJECTIVES: Disrupted sleep is one of the prominent but often overlooked presenting symptoms in the clinical course of psychotic disorders. The aims of this study were to examine the prevalence of sleep disturbances, particularly insomnia and nightmares, and their prospective associations with the risk of suicide attempts in patients with schizophrenia-spectrum disorders. METHODS: A naturalistic longitudinal study was conducted in outpatients diagnosed with schizophrenia-spectrum disorders recruited from the psychiatric outpatient clinic of a regional university-affiliated public hospital in Hong Kong. A detailed sleep questionnaire was completed by 388 patients at baseline in May-June 2006. Relevant clinical information was extracted from clinical case notes from June 2007-October 2014. RESULTS: Prevalence of frequent insomnia and frequent nightmares was 19% and 9%, respectively. Baseline frequent insomnia was significantly associated with an increased incidence of suicide attempts during the
Schizophrenia is a psychotic disorder with symptoms generally lasting longer than 6 months. According to the Gale Encyclopedia of Mental Health, schizophrenia is a disorder or group of disorders whose symptoms include disturbances in thinking, emotional responsiveness, and behavior. Schizophrenia is associated with abnormalities of brain structure and function, disorganized speech and behavior, delusions, and hallucinations. DSM-IV: 295.90 ICD-10: F20.9 Other psychotic disorders include:. Schizoaffective disorder: symptoms of schizophrenia and a mood disorder such as depression or bipolar disorder. Schizophreniform disorder: symptoms of schizophrenia that last between 1-6 months DSM-IV: 295.40 ICD-10: F20.81. Brief psychotic disorder: symptoms of psychosis that occurs in a sudden, short period of time, usually in response to a traumatic or emotional event DSM-IV: 298.8 ICD-10: F23 ...
TY - GEN. T1 - Predicting First-Episode Psychosis Associated with Cannabis Use with Artificial Neural Networks and Deep Learning. AU - Stamate, Daniel. AU - Alghamdi, Wajdi. AU - Stahl, Daniel. AU - Pu, Ida. AU - Murtagh, Fionn. AU - Belgrave, Danielle. AU - Murray, Robin. AU - di Forti, Marta. N1 - The final authenticated version is available online at https://doi.org/10.1007/978-3-319-91479-4_57.. PY - 2018/5/18. Y1 - 2018/5/18. N2 - In recent years, a number of researches started to investigate the existence of links between cannabis use and psychotic disorder. More recently, artificial neural networks and in particular deep learning have set a revolutionary wave in pattern recognition and machine learning. This study proposes a novel machine learning approach based on neural network and deep learning algorithms, to developing highly accurate predictive models for the onset of first-episode psychosis. Our approach is based also on a novel methodology of optimising and post-processing the ...
TY - JOUR. T1 - The impact of inflammation on neurocognition and risk for psychosis. T2 - a critical review. AU - Kogan, Sophia. AU - Ospina, Luz H.. AU - Mittal, Vijay A.. AU - Kimhy, David. PY - 2020/10/1. Y1 - 2020/10/1. N2 - Neurocognitive difficulties are highly prevalent among people with schizophrenia and have been linked to increased inflammation, as well as dysfunction and disability. Poor neurocognitive functioning has also been documented in individuals at clinical high risk for psychosis (CHR) and a burgeoning literature point to alterations in inflammation markers in this population. However, there is limited information regarding the putative link between inflammation and neurocognition in CHR individuals, and the potential role of inflammation in the development of cognitive difficulties and psychosis. As previous reports indicate that early treatment in schizophrenia is associated with better outcomes, there is an urgent need to identify neurobiological mechanisms underlying ...
Psychotic disorders are mental disorders in which a persons personality is severely confused and that person loses touch with reality. When a psychotic episode occurs, a person becomes unsure about what is real and what isnt real and usually experiences hallucinations, delusions, off-the-wall behavior, chaotic speech and incoherency. A person behaving in this manner is often referred to as being schizophrenic.. A hallucination is an internal sensory perception that isnt actually present and can be either visual or auditory. Smelling odors or having a funny taste in the mouth are other hallucinations that may occur. A delusion is defined as a false, inaccurate belief that a person holds on to. A grandiose delusion occurs when a person believes that their life is out of proportion as compared to what is really true. For example, a patient may believe that she is God or Jesus Christ. A persecutory delusion occurs when a person believes that there is a conspiracy amongst others to attack, punish ...
Originals A. Ros-Morente 1 G. Rodríguez-Hansen 1 R. Vilagrà-Ruiz 1 T. R. Kwapil 2 N. Barrantes-Vidal 3 Adaptation of the Wisconsin Scales of Psychosis Proneness to Spanish 1 Clinical Psychology and Health
Social anxiety is a common problem in psychotic disorders. The Liebowitz Social Anxiety Scale, Self-Rating version (LSAS-SR) is a widely used instrument to capture different aspects of social anxiety, but its psychometric properties have not been tested in this patient group. The aims of the present study were to evaluate the psychometric properties of the LSAS-SR in patients with first episode psychosis, to investigate whether it differentiated between active and passive social withdrawal and to test which clinical factors contributed to current level of social anxiety ...
Social anxiety is a common problem in psychotic disorders. The Liebowitz Social Anxiety Scale, Self-Rating version (LSAS-SR) is a widely used instrument to capture different aspects of social anxiety, but its psychometric properties have not been tested in this patient group. The aims of the present study were to evaluate the psychometric properties of the LSAS-SR in patients with first episode psychosis, to investigate whether it differentiated between active and passive social withdrawal and to test which clinical factors contributed to current level of social anxiety ...
Define affective psychosis. affective psychosis synonyms, affective psychosis pronunciation, affective psychosis translation, English dictionary definition of affective psychosis. n a severe mental disorder characterized by extreme moods of either depression or mania Collins English Dictionary - Complete and Unabridged, 12th Edition...
Is Psychotic Disorder a common side effect of Ritalin? View Psychotic Disorder Ritalin side effect risks. Female, 32 years of age, was diagnosed with attention deficit/hyperactivity disorder, bipolar disorder, histrionic personality disorder, social alcohol drinker, sleep disorder and took Ritalin 5 Mg, Bid. Patient was hospitalized.
The aim of the present study was to examine the relevance of depressive symptoms during an acute schizophrenic episode for the prediction of treatment response. Two hundred inpatients who fulfilled DSM-IV criteria for schizophrenia or schizophreniform disorders were assessed at hospital admission and after 6 weeks of inpatient treatment using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Rating Scale for Depression (HAM-D). Depressive symptoms showed positive correlations with both positive and negative symptoms at admission and after 6 weeks, and decreased during 6 weeks of treatment. Pronounced depressive symptoms (HAM-D score, or =16) were found in 28% of the sample at admission and in 9% after 6 weeks of treatment. Depressive symptoms at admission predicted a greater improvement of positive and negative symptoms over 6 weeks of treatment, but also more, rather than fewer remaining symptoms after 6 weeks. Both results, however, lost statistical significance when analyses ...
Objective: To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders.. Method: This prospective, randomized, open-label study was conducted from February 2001 to February 2005. Data for the present investigation were obtained from a large epidemiologic and 3-year longitudinal intervention program of first-episode psychosis (DSM-IV criteria) conducted at the outpatient clinic and the inpatient unit at the University Hospital Marques de Valdecilla, Santander, Spain. One hundred four patients randomly assigned to haloperidol (N = 35), olanzapine (N = 30), or risperidone (N = 39) who completed clinical and cognitive evaluations at baseline, 6 months, and 1 year were included in the final analysis. Thirty-seven healthy individuals were also longitudinally assessed. A neuropsychological battery that comprised 9 cognitive domains was used. The contribution of clinical changes, concomitant medications, and the severity ...
TY - JOUR. T1 - N400 abnormalities in late life schizophrenia and related psychoses. AU - Olichney, John M. AU - Iragui, Vicente J.. AU - Kutas, Marta. AU - Nowacki, Ralph. AU - Jeste, Dilip V.. PY - 1997/7/1. Y1 - 1997/7/1. N2 - The N400, an event-related brain potential (ERP) sensitive to semantic congruity, has been reported to have increased latency and/or reduced amplitude in young adults with schizophrenia. Little is known, however, regarding the N400 in older schizophrenia patients, especially those with late onset. We studied 18 middle-aged and elderly patients with schizophrenia and related psychoses (nine with early-onset psychosis (EOP) and nine with late-onset psychosis (LOP)), and nine normal comparison (NC) subjects. Subjects read words which were semantically incongruent (50%) or congruent (50%) with a preceding spoken phrase which defined either an antonymic or categorical relationship. The LOP group had a significantly later peak latency of the N400 congruity effect compared to ...
TY - JOUR. T1 - Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder. AU - Risch, S. Craig. AU - Horner, Michael D.. AU - McGurk, Susan R.. AU - Palecko, Simmy. AU - Markowitz, John S.. AU - Nahas, Ziad. AU - DeVane, C. Lindsay. PY - 2006/10. Y1 - 2006/10. N2 - Donepezil, 5 mg/d for 6 wk then 10 mg/d for 6 wk, and placebo daily for 12 wk in a double-blind cross-over paradigm, was added to the therapeutic regimen of 13 patients with schizophrenia or schizoaffective disorders, clinically stable on atypical antipsychotic medications. Patients had varying degrees of depressive symptoms, ranging from no depression to clinically significant depression. There was no worsening or induction of depression in individual patients or the group as a whole. In addition there was a statistically significant antidepressant effect in the group as a whole during the donepezil condition and a clinically significant antidepressant effect in the patients with clinically significant ...
Medication Changes for Schizophrenia and Schizoaffective Disorder … People with schizophrenia and schizoaffective disorder are no strangers to medication changes (Mental Health Medication Changes Require a Doctors Input).
Ive been worrying about this for way too long. Since the beginning of this year Ive become obsessively scared of schizophrenia. This topic is answered by a medical expert.
TY - JOUR. T1 - Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis. T2 - the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial. AU - Pagsberg, Anne Katrine. AU - Jeppesen, Pia. AU - Klauber, Dea Gowers. AU - Jensen, Karsten Gjessing. AU - Rudå, Ditte. AU - Stentebjerg-Olesen, Marie. AU - Jantzen, Peter. AU - Rasmussen, Simone. AU - Saldeen, Eva Ann-Sofie. AU - Lauritsen, Maj-Britt Glenn. AU - Bilenberg, Niels. AU - Stenstrøm, Anne Dorte. AU - Nyvang, Louise. AU - Madsen, Sarah. AU - Werge, Thomas M. AU - Lange, Theis. AU - Gluud, Christian. AU - Skoog, Maria. AU - Winkel, Per. AU - Jepsen, Jens Richardt M.. AU - Fagerlund, Birgitte. AU - Correll, Christoph U. AU - Fink-Jensen, Anders. N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.. PY - 2017/8. Y1 - 2017/8. N2 - BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because ...
TY - JOUR. T1 - Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity. AU - Counotte, J. AU - Drexhage, H A. AU - Wijkhuijs, J M. AU - Pot-Kolder, R. AU - Bergink, V. AU - Hoek, H W. AU - Veling, W. N1 - Copyright © 2018 Elsevier Inc. All rights reserved.. PY - 2018/3. Y1 - 2018/3. N2 - BACKGROUND: Psychotic disorders are characterized by a deranged immune system, including altered number and function of Natural Killer (NK) and T cells. Psychotic disorders arise from an interaction between genetic vulnerability and exposure to environmental risk factors. Exposure to social adversity during early life is particularly relevant to psychosis risk and is thought to increase reactivity to subsequent minor daily social stressors. Virtual reality allows controlled experimental exposure to virtual social stressors.AIM: To investigate the interplay between social adversity during early life, cell numbers of NK cells and T helper subsets and ...
Discuss the latest evidence of the role of genetic predisposition to psychoses in the development of substance-induced psychotic disorder (SIPD ...
Haukvik, Unn Kristin H.; Hartberg, Cecilie Bhandari; Nerland, Stener; Jørgensen, Kjetil Nordbø; Lange, Elisabeth; Simonsen, Carmen Elisabeth; Nesvåg, Ragnar; Dale, Anders; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2016). No progressive brain changes during a 1-year follow-up of patients with first-episode psychosis. Psychological Medicine. ISSN 0033-2917. 46(3), s 589- 598 . doi: 10.1017/S003329171500210X Vis sammendrag Background. First-episode psychosis (FEP) patients show structural brain abnormalities. Whether the changes are progressive or not remain under debate, and the results from longitudinal magnetic resonance imaging (MRI) studies are mixed. We investigated if FEP patients showed a different pattern of regional brain structural change over a 1-year period compared with healthy controls, and if putative changes correlated with clinical characteristics and outcome. Method. MRIs of 79 FEP patients [SCID-I-verified diagnoses: schizophrenia, psychotic bipolar disorder, ...
The Early Psychosis Intervention Clinic (EPIC) is a specialized treatment program for patients who are currently experiencing a psychotic episode or who have recieved a diagnosis of a psychotic disorder within the past year.
Clinical psychology; assessment and psychological treatment. Trauma psychology.. Supervision of Master theses. 25 Ingvild Rasmussen. Childhood Maltreatment Trauma: A Comparison Between Two Groups of Adult Patients in Mental Health Treatment. Det psykologiske fakultet: Universitetet i Bergen 2016. 24 Lise Amundal, Marius A. Jakobsen & Paul Axel Sverstad. An Empirical Study of the Predictive Value of Criteria A1 and A2 on Posttraumatic Stress Symptoms in a Clinical Sample. Det psykologiske fakultet: Universitetet i Bergen 2015. 23 Chhabra, Smiti; Kristiansen, Ingrid. Childhood Maltreatment, General Psychological Symptoms and Interpersonal Difficulties in an Adult Clinical Sample. Det psykologiske fakultet: Universitetet i Bergen 2014. 22 Mørkved, Nina; Endsjø, Mathilde. Childhood Trauma Maltreatment in Patients with Non-affective Psychosis as Compared to Patients Suffering from Other Mental Health Disorders. Det psykologiske fakultet: Universitetet i Bergen 2014. 21 Ekman, B; Holen, Duva. ...
Veliparib combined with carboplatin (VC) was an experimental regimen evaluated in the biomarker-rich neoadjuvant I-SPY 2 trial for breast cancer. VC showed improved efficacy in the triple negative signature. However, not all triple negative patients achieved pathologic complete response and some HR+HER2- patients responded. Pre-specified analysis of five DNA repair deficiency biomarkers (BRCA1/2 germline mutation; PARPi-7, BRCA1ness, and CIN70 expression signatures; and PARP1 protein) was performed on 116 HER2- patients (VC: 72 and concurrent controls: 44). We also evaluated the 70-gene ultra-high risk signature (MP1/2), one of the biomarkers used to define subtype in the trial. We used logistic modeling to assess biomarker performance. Successful biomarkers were combined using a simple voting scheme to refine the predicted sensitive group and Bayesian modeling used to estimate the pathologic complete response rates. BRCA1/2 germline mutation status associated with VC response, but its low ...
In the movies, newspapers and other media sources, psychosis is often linked to violence and aggression. However, contrary to popular belief, people diagnosed with a psychotic disorder are more often the victim than the perpetrator of a crime. Although victimization can have a major impact on peoples lives, no evidence-based intervention targeted at victimization in psychosis is available. To prevent victimization of individuals with a psychotic disorder a body-oriented resilience therapy has been developed, based on pre-defined putative associated factors derived from the literature.. In this dissertation Elise van der Stouwe firstly assessed the efficacy of this therapy at the behavioral level. In a pilot study aimed at testing the therapy, patients subjectively indicated a positive effect of BEATVIC on (risk factors of) victimization. However, in the subsequent multi-center randomized controlled trial van der Stouwe and her colleagues found no differences between the BEATVIC group and the ...
Turn on the TV for two or three hours and youre likely to see a commercial for Abilify - one of the newer antipsychotic medications being used to treat a variety of symptoms and disorders. Its advertised as an adjunct medication for those taking antidepressants for depression who arent quite experiencing the benefits theyd hoped for. Antipsychotics, as the name suggests, were primarily developed to treat symptoms of psychosis. For years, they were used almost exclusively for the treatment of the two most common psychotic disorders - schizophrenia and schizoaffective disorder. The two most common psychotic symptoms are hallucinations - e.g. hearing voices - and delusions - e.g. the bizarre belief that aliens are controlling your mind via an implanted microchip. For many individuals suffering from psychosis, these medications have been life-changing. Schizophrenia is one of the most debilitating and serious psychiatric disorders known to humankind. These drugs - which were first used in the ...
Children reporting psychotic experiences (PEs) are at increased risk of developing psychosis in adulthood. Cognitive deficits and anxiety disorders often precede psychotic disorders and are associated with higher risk of PEs. While the high activity alleles of variants within COMT have been associated with cognitive deficits, and the low activity alleles with higher risk of anxiety disorders, no associations of COMT with PEs have been found. One possible explanation is that the association between COMT and PEs is indirect, through cognitive function and anxiety disorders. We examined whether the association between PEs and COMT (four single nucleotide polymorphisms and three haplotypes) is indirect, through cognition or anxiety disorders. 6,784 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC) were genotyped and completed neurocognitive assessments at ages 8 and 11, as well as semi-structured interviews for anxiety disorders and PEs at ages 10 and 12, respectively. ...
BACKGROUND: The optimal pharmacological treatment of unipolar psychotic depression is uncertain. AIMS: To compare the clinical effectiveness of pharmacological treatments for patients with unipolar psychotic depression. METHOD: Systematic review and meta-analysis of randomised controlled trials. RESULTS: Ten trials were included in the review. We found no evidence that the combination of an antidepressant with an antipsychotic is more effective than an antidepressant alone. This combination was statistically more effective than an antipsychotic alone. CONCLUSIONS: Antidepressant monotherapy and adding an antipsychotic if the patient does not respond, or starting with the combination of an antidepressant and an antipsychotic, both appear to be appropriate options for patients with unipolar psychotic depression. However, clinically the balance between risks and benefits may suggest the first option should be preferred for many patients. Starting with an antipsychotic alone appears to be inadequate.
Objective: This was to determine the prevalence of suicidal behaviours prior to and during the first year of treatment in a comprehensive early psychosis program (EPP) and to identify predictors of suicidal behaviour.. Method: In a cohort study of 238 subjects, patients were assessed at initial presentation to an EPP and 1 year later. Measures included a range of demographic variables, suicide attempts, depression, positive and negative symptoms, social functioning and substance misuse.. Results: Although 15.1% attempted suicide prior to program entry, only 2.9% made an attempt in the year after program entry and 0.4% completed suicide. No further attempts were seen in those with previous parasuicide. These rates are lower than other published rates for first-episode patients.. Conclusion: It is possible that specifically designed first-episode programs can reduce the suicidal behaviour in this high-risk population. The low prevalence of attempted suicide makes modeling predictors difficult. ...
Lutgens, D., Malla, A., Joober, R. and Iyer, S. (2015), The impact of caregiver familiarity with mental disorders on timing of intervention in first-episode psychosis. Early Intervention in Psychiatry, 9: 388-396. doi: 10.1111/eip.12121 ...
Verbal memory improvement in first-episode psychosis APOE-epsilon4 carriers: a pleiotropic effect? Fidel Vila-Rodriguez,1 Donna J Lang,2 Heather Baitz,3 Kristina Gicas,3 Allen E Thorton,3 Thomas S Ehmann,1 Geoff N Smith,1 Alasdair M Barr,4 Ivan J Torres,1 Lili C Kopala,1 G William McEwan,1 Daniel J Müller,5 James L Kennedy,5 William G Honer11Department of Psychiatry, 2Division of Neuroradiology, Department of Radiology, The University of British Columbia, Vancouver, 3Department of Psychology, Simon Fraser University, Burnaby, 4Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, 5Department of Psychiatry, Centre for Mental Health and Addictions, University of Toronto, Toronto, ON, CanadaBackground: Verbal memory impairment is a core feature in schizophrenia even at early stages of the disease, but its etiopathogenesis is not fully understood. The APOE-ε4 is the main genetic risk factor for late-onset Alzheimers disease. Our primary goal was
A person with psychotic depression has detached from reality. Psychotic depression symptoms can be frightening, but psychotic depression treatment is available.
TY - JOUR. T1 - Cognitive burden of anticholinergic medications in psychotic disorders. AU - Eum, Seenae. AU - Hill, S. Kristian. AU - Rubin, Leah H.. AU - Carnahan, Ryan M.. AU - Reilly, James L.. AU - Ivleva, Elena I.. AU - Keedy, Sarah K.. AU - Tamminga, Carol A.. AU - Pearlson, Godfrey D.. AU - Clementz, Brett A.. AU - Gershon, Elliot S.. AU - Keshavan, Matcheri S.. AU - Keefe, Richard S.E.. AU - Sweeney, John A.. AU - Bishop, Jeffrey R.. N1 - Funding Information: C.A.T. has received support from Intracellular Therapies (ITI, Inc.), PureTech Ventrues, Eli Lilly Pharmaceuticals, Sunovion, Astellas, Merck (ad hoc consulting), International Congress on Schizophrenia Research (unpaid volunteer), NAMI (unpaid volunteer), American Psychiatric Association (Deputy Editor), and Finnegan Henderson Farabow Garrett & Dunner, LLP. J.L.R. has received investigator initiated support from Naurex, Inc. R.S.E.K. has received investigator initiated support from the Department of Veterans Affair, Feinstein ...
Shared psychotic disorder, or folie à deux, is a rare delusional disorder shared by 2 or, occasionally, more people with close emotional ties. An extensive review of the literature reveals cases of folie à trois, folie à quatre, folie à famille (all family members), and even a case involving a dog.
Psychotic disorders such as schizophrenia fascinate and challenge mental health providers, who seek to understand these conditions and assist individuals and families who suffer from them. Schizophrenia causes significant disability and increased mortality, and practitioners struggle to identify and manage the condition appropriately. It can be particularly difficult for trainees and students to grasp the basics in a way that can effectively inform clinical care. Hopefully, this book will help. This volume of the Pittsburgh Pocket Psychiatry series provides a comprehensive overview of schizophrenia and related psychotic disorders, which will assist psychiatry residents, medical students, and other professional trainees in diagnosing and treating individuals with these conditions. The book draws on the latest scientific research to discuss the neurobiology and pathophysiology of these illnesses; reviews the key clinical and diagnostic features of psychotic illnesses consistent with the revised ...
Schizoaffective disorder shows both the psychotic thought problems of schizophrenia and the mood problems of major depressive disorder or bipolar disorder.
Bentall, R.P., Fernyhough, C., Morrison, A.P., Liwis, S., Corcoran, R. (2007). Prospects for a cognitive-developmental account of psychotic experiences. British Journal of Clinical Psychology, 46, 155-173. - Advantages of a (neuro)developmental framework when considering psychoses. - Developmental precursors of psychosis. - The role of cognitive processes in psychotic symptoms. - Cognitive and sociocognitive abnormalities. - …
Weibell, Melissa Anne E; Johannessen, Jan Olav; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Brønnick, Kolbjørn Kallesten; Haahr, Ulrik; Joa, Inge; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; Stain, Helen J.; Friis, Svein & Hegelstad, Wenche (2019). Early substance use cessation improves cognition-10 years outcome in first-episode psychosis patients. Frontiers in Psychiatry. ISSN 1664-0640. 10 . doi: 10.3389/fpsyt.2019.00495 Full text in Research Archive. Show summary Background: Cognitive impairment may be a risk factor for, as well as a consequence of, psychosis. Non-remitting symptoms, premorbid functioning, level of education, and socioeconomic background are known correlates. A possible confounder of these associations is substance use, which is common among patients with psychosis and linked to worse clinical outcomes. Studies however show mixed results for the effect of ...