Pseudomonas aeruginosa bloodstream infection (BSI) is predominantly acquired in the hospital setting. Community-onset infection is less common. Differences in epidemiology, clinical features, microbiological factors and BSI outcomes led to the separation of bacterial community-onset BSI into the categories of healthcare-associated infection (HCAI) and community-acquired infection (CAI). Community-acquired P. aeruginosa BSI epidemiology is not well defined in the literature. In addition, it is also not clear if the same factors separate CAI and HCAI BSI caused by P. aeruginosa alone. A retrospective multicentre cohort study was performed looking at P. aeruginosa BSI from January 2008 to January 2011. Strict definitions for HCAI and CAI were applied. Extensive epidemiological, clinical and outcome data were obtained. Thirty-four CAI episodes and 156 HCAI episodes were analysed. The CAI group could be characterised into seven distinct categories based on comorbidities and clinically suspected ...
Pseudomonas infections are diseases caused by a bacterium from the genus Pseudomonas. The bacteria are found widely in the environment, such as in soil, water, and plants. They usually do not cause infections in healthy people. If an infection does occur in a healthy person, it is generally mild. More severe infections occur in people who are already hospitalized with another illness or condition, or people who have a weak immune system. Pseudomonades are fairly common pathogens involved in infections acquired in a hospital setting. A pathogen is a microorganism that causes disease. Infections acquired in a hospital are called nosocomial infections. Infections can occur in any part of the body. Symptoms depend on which part of the body is infected. Antibiotics are used to treat the infections. Pseudomonas infection could be fatal in people who are already very ill.. ...
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CF is an inherited disease that causes mucus to build up in the lungs and digestive tract, which can cause lung infections and digestive problems. It is the most common type of chronic lung disease in children and young adults and may result in early death. There is no cure for this disease. The primary cause of death in individuals with CF is progressive obstructive pulmonary disease associated with chronic Pseudomonas aeruginosa (PA) infection. PA infection can occur early in life and can become highly resistant to antibiotics. Once an individual has been diagnosed with chronic PA infection, it is almost impossible to manage effectively. The need exists for an effective treatment to control and eliminate PA infection. Past research has shown that if PA infection is treated early, there is a greater likelihood that it may be eliminated completely. This study will examine two treatment regimens to compare which is more effective at eliminating PA infection. In the first regimen, participants ...
Sánchez-Diener I1, Zamorano L2, Peña C3, Ocampo-Sosa A4, Cabot G1, Gómez-Zorrilla S5, Almirante B6, Aguilar M7, Granados A8, Calbo E9, Baño JR10, Rodríguez-López F11, Tubau F12, Martínez-Martínez L11, Navas A13, and Oliver A14. 1Servicio de Microbiología and Unidad de Investigación, Hospital Son Espases, Instituto de Investigación Sanitaria de les Illes Balears (IdISBa), Palma de Mallorca,…
Sigma-Aldrich offers abstracts and full-text articles by [Amber L Jolly, Desire Takawira, Olufolarin O Oke, Sarah A Whiteside, Stephanie W Chang, Emily R Wen, Kevin Quach, David J Evans, Suzanne M J Fleiszig].
MBio. 2013 Mar 12;4(2):e00032-13. doi: 10.1128/mBio.00032-13. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
This chapter reviews the observations supporting the idea that acute and chronic Pseudomonas aeruginosa infections represent distinct modes of host-pathogen interaction. The virulence factors associated with acute infections and chronic infections are discussed, with a focus on data obtained from human subject-based studies, when possible. P. aeruginosa expresses many virulence factors that can damage host cells and which contribute to infection in both humans and animal models. Ectopic expression of virulence factor regulator (Vfr) in mucA22 strains restored expression of ExoS, type IV pilus (TFP), and elastase, confirming that downregulation of Vfr is responsible for decreased virulence factor expression in mucoid strains under the conditions evaluated in this study. While it is clear that regulators of TFP biogenesis and function are intimately associated with the control of Vfr and cyclic AMP (cAMP) expression, the mechanism that links twitching motility and Vfr remains to be elucidated. rsmZ and
That research had shown that the bacteria "travelled up to 4m and stayed viable for 45 minutes after being coughed into the air," says lead researcher Lidia Morawska in a university press release.. For their experiment, the researchers recruited two individuals- one of whom had cystic fibrosis, and the other of whom had a chronic pseudomonas aeruginosa infection. Airborne cough droplets were collected from both patients, although there was more focus on the patient who was infected.. Despite the droplets of infected saliva quickly losing moisture, contaminated particles remained airborne for quite some time after the infected individual coughed or sneezed, the researchers found. This was particularly the case for larger droplets.. "We found that the concentration of active bacteria in the dried droplets showed rapid decay with a 10-second half-life for most of the bacteria but a subset of bacteria had a half-life of more than 10 minutes," reveals Morawska.. LIKE STUDIES? FOLLOW STUDYFINDS.ORG ON ...
A seventh baby is believed to have contracted the Pseudomonas infection at the Royal hospital. A seventh baby is believed to have contracted the Pseudomonas infection at the Royal hospi
Takei Y, however, is often short meidcation so take into account side-effects such as proximal myopathy and poor wound healing. Opal SM, Jhung JW, Keith JC Jr, et al Recombinant human interleukin-11 in experimental Pseudomonas aeruginosa sepsis in immunocompromised animals. The size of the system and the amount of in-house (vs.
Introduction: Changes in the prevalence of respiratory pathogens in CF may reflect improved therapeutic strategies and clinical practice within a CF centre.. Aims: We hypothesized that active microbiological surveillance and a low threshold for long term nebulised antibiotics might reduce the prevalence of respiratory pathogens in patients with CF.. Methods: Retrospective review of data of patients under full care at a paediatric CF centre in Cardiff between 1998(n=80) and 2011(n=70). We calculated the number of isolates for common pathogens from 1998 onward (expressed as a percentage for each year); mean number of respiratory cultures taken for each patient per year; and the rate of chronic P aeruginosa (Lee 2003) from 2002 onward. Changes in prevalence over time were assesed by linear regression.. Results:Non-significant increase in mean (SD) number of respiratory cultures from 5.3(3.22) to 7.4(2.89) per patient/year.The prevalence of P aeruginosa infection decreased significantly from 43.8% ...
... Aeruginosa lung infection and antibiotic resistance is a growing problem. 'New classes of inhaled
Community acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide. The contribution of Pseudomonas aeruginosa to both disease burden and antibiotic resistance is unclear; Restrepo et al (European Respiratory Journal 2018;52: 1701190) present a point-prevalence study to address this gap in the data. This multinational study of hospitalised patients investigated the prevalence, risk factors and antibiotic resistance profiles of P. aeruginosa-CAP in 54 countries. A total of 3193 patients were included, all had microbiological testing on admission and had a confirmed diagnosis of CAP. Prevalence of P. aeruginosa-CAP was 4.2 % (133/3193) which represented 11.3 % (133/1173) of all patients with a positive bacterial culture result. Almost half of these patients had an antibiotic-resistant strain (64/133, 48 %; 2.0 % of total cohort) and a quarter had a multi-drug resistant strain of P. aeruginosa (33/133, 25 %; 1.0 % of total cohort). Prior Pseudomonas infection/colonisation (OR ...
Throat cultures werent as good this time. She had 2 clean cultures since her first pseudomonas infection last April. I was really hoping for a 3rd clean culture, but luck was not on our side. Her lungs are culturing MRSA, so were going to do a round of bactrum and see if it can eradicate it. The nurse coordinator explained that, just like with the pseudos, they want to try to catch and treat a MRSA infection quickly so it doesnt become a more serious issue and so they can reduce the amount of potential damage it can do to the lungs. I did give her a heads up about Judiths 2 MRSA infections in the abscesses over the summer, just in case they wanted to move to a stronger antibiotic. Since the cultures for the lungs are slightly different than the skin cultures, she said they can still try the bactrum and take it from there. One good point we discovered from the culture is she is still pseudo-free, so at least we dont have to worry about that on top of the MRSA ...
My senior year, he developed an intramuscular sarcoma that appeared very histologically aggressive. He had an entire muscle in his leg removed, a large skin graft, got a Pseudomonas infection, spent a week in the hospital. He was a great patient until you put him in a kennel. He broke out of the ICU and went wandering to find the technician in the night. He developed a slough from extravascular administration of antibiotics in his other front leg and wore two full leg bandages for weeks. In July after graduation and months after surgery, he threw a clot to his front leg and I thought we were toast, but he recovered after 24 hours in the hospital again. He never was aggressive or even resistant to treatment, but by the end of vet school he hated hospitals. I promised him then Id never leave him in one again ...
The philosophy in traditional drug design, i.e., the "one gene, one drug, one disease" paradigm, focuses on the individual properties of a protein, for example, whether the deletion of a gene is lethal to an organism and if it is, then inhibition of the product of the gene by a drug should also be lethal. However, many effective drugs have been found to affect a handful of targets instead of a single protein. Recently, understanding of biological networks and molecule functionality has given rise to a new discipline, network pharmacology, that provides the opportunity to identify new drug targets in an infectious organism, while avoiding targets that cause toxicity in the host. Our group recently combined a genes essentiality and network properties to facilitate the identification of potential drug targets in treating Pseudomonas infection.. ...
I havent swore on this blog much, coz its a limited form of communication, isnt it? Yesterday I felt like it but it would have just turned out like "the fucking fuckers fucked, it can get fucked for fucks sake" or something. And all I really have is questions with no answers. And I feel like Ive been hit by a stealth CF infection with added wheeze factor. Last summer I was 10 stone 10, now Ive dropped down to 9 stone 12 which has completely mystified me; I have no idea how this happened. Can a stealth pseudomonas infection really rob me of so many calories? The doctor reckons it could be but I remain baffled...On the plus side my stomach is really flat ...
HIPS researchers produced a molecule that provides a way to visualise Pseudomonas infections weiter … Source:: http://idw-online.de/de/news686100. ...
1 Answer - Posted in: cancer, chronic, hospital, pseudomonas - Answer: Hi, my name is Liz, how did they treat the pseudomonis? What antibiotics ...
Semantic Scholar extracted view of Experimental Pseudomonas burn sepsis--evaluation of topical therapy. by Thomas J. Krizek et al.
Pseudomonas aeruginosa lung infections are a major cause of death in cystic fibrosis and hospitalized patients. Treating these infections is becoming difficult due to the emergence of conventional antimicrobial multiresistance. While monosaccharides have proved beneficial against such bacterial lung infection, the design of several multivalent glycosylated macromolecules has been shown to be also beneficial on biofilm dispersion. In this study, calix[4]arene-based glycoclusters functionalized with galactosides or fucosides have been synthesized. The characterization of their inhibitory properties on Pseudomonas aeruginosa aggregation, biofilm formation, adhesion on epithelial cells, and destruction of alveolar tissues were performed. The antiadhesive properties of the designed glycoclusters were demonstrated through several in vitro bioassays. An in vivo mouse model of lung infection provided an almost complete protection against Pseudomonas aeruginosa with the designed glycoclusters.. ...
Gilead is developing a broad spectrum combination antibiotic (FTI) consisting of fosfomycin (an antibiotic with activity against gram-positive and gram-negative bacteria) and tobramycin (an aminoglycoside antibiotic with potent gram-negative activity) for treatment of patients with CF. FTI offers a potential option for treatment of CF lung infections. It is important to note that the concentration of tobramycin in FTI is lower than that of the approved dose of inhaled tobramycin alone, thereby demonstrating the potential of FTI to minimize long-term toxicity from repeated exposure to aminoglycosides like tobramycin. This study will evaluate the safety and efficacy of 2 dose combinations of fosfomycin/tobramycin for inhalation (FTI), following a 28-day course of Aztreonam for Inhalation (AZLI) in patients with cystic fibrosis and Pseudomonas aeruginosa lung infection ...
Emond et al are reporting in Nat Genetics the identification of DCTN4 as a modifier for P.aeruginosa infection in patients with cystic fibrosis. It is a well-established fact that the majority of patients with cystic fibrosis develop acute and chronic P.aerugonisa infections which are associated with a worse clinical outcome. The authors selected and exome sequenced 91 patients from the EPIC collection with cystic fibrosis and P.aeruginosa and after performing logistic regression adjusted for ancestry and for CFTR mutation risk group identified DCTN4 as the only modifier gene. Dynactin 4 is a component of the dynein-dependent motor that moves autophagosomes along microtubules into lysosomes for degradation as part of the autophagy process which has an essential role in the clearance of P. aeruginosa. The presence of at least one DCTN4 missense variant was significantly associated with both early age of first P. aeruginosaâ€"positive culture and with early age at onset of chronic P. aeruginosa ...
Clinical trial: Efficacy & Tolerability of Tobramycin Podhaler in Bronchiectasis Patients With Chronic Pseudomonas Aeruginosa Infection
A total of 3,700 Pseudomonas aeruginosa isolates were collected from 17 general hospitals in Japan from 1992 to 1994. Of these isolates, 132 carbapenem-resistant strains were subjected to DNA hybridization analysis with the metallo-beta-lactamase gene (blaIMP)-specific probe. Fifteen strains carrying the metallo-beta-lactamase gene were identified in five hospitals in different geographical areas. Three strains of P. aeruginosa demonstrated high-level imipenem resistance (MIC, , or = 128 micrograms/ml), two strains exhibited low-level imipenem resistance (MIC, , or = 4 micrograms/ml), and the rest of the strains were in between. These results revealed that the acquisition of a metallo-beta-lactamase gene alone does not necessarily confer elevated resistance to carbapenems. In several strains, the metallo-beta-lactamase gene was carried by large plasmids, and carbapenem resistance was transferred from P. aeruginosa to Escherichia coli by electroporation in association with the acquisition of the ...
A total of 183 patients were colonized or infected with multidrug-resistant Pseudomonas aeruginosa isolates at a hospital in Spain during 2007-2010; prevalence increased over this period from 2.8% to 15.3%. To characterize these isolates, we performed molecular epidemiologic and drug resistance analysis. Genotyping showed that 104 (56.8%) isolates belonged to a single major clone (clone B), which was identified by multilocus sequence typing as sequence type (ST) 175. This clone was initially isolated from 5 patients in 2008, and then isolated from 23 patients in 2009 and 76 patients in 2010. PCR analysis of clone B isolates identified the bla(VIM-2) gene in all but 1 isolate, which harbored bla(IMP-22). ST175 isolates were susceptible to only amikacin (75%) and colistin (100%). Emergence of the ST175 clone represents a major health problem because it compromises therapy for treatment of P. aeruginosa nosocomial infections ...
Resistant Pseudomonas Aeruginosa Infections Drugs Market Insights: Global Industry Analysis, Market Drivers, Restraints, Opportunities, Applications, Trends And Forecasts 2020-2026
Summary Pharmaceutical and Healthcare disease pipeline guide Resistant Pseudomonas aeruginosa Infections - Pipeline Review, H1 2017, provides an overview o
Twenty-three patients (85.2%) were infected with MDR P. aeruginosa, confirmed with cultures and resistance tests, during the ICU stay. In greater part, they were isolated from respiratory and urinary tract infections (33.3% and 25.9%, respectively). Four patients were treated empirically, with 50% of therapy response. The study group presented a mean age of 63 years, 51.9% males, with a mean Acute Physiology and Chronic Health Evaluation II score of 24.63. Sixty-three percent of our patients were first admitted to the hospital with community-acquired infection, none caused by P. aeruginosa. The most frequent cause for ICU admission was communitarian or nosocomial respiratory tract infection (29.9%). The mean time of polimixin B use was 15.59 days. Twelve patients (44%) used imipinem, 12 patients (44%) used teicoplanin and three patients (11%) used vancomicin, for more than 3 days, during the ICU stay before polimixin B use. After treatment with polimixin B, we had 40.7% response and improvement ...
Cyclic-diguanylate (c-di-GMP) is a widespread bacterial signal molecule that plays a major role in the modulation of cellular surface components, such as exopolysaccharides and fimbriae, and in the establishment of a sessile life style. Here, we report that intracellular c-di-GMP levels influence cupA-encoded fimbriae expression in Pseudomonas aeruginosa. In an autoaggregative P. aeruginosa small colony variant (SCV) CupA fimbriae and the intracellular c-di-GMP concentration were found to be enhanced as compared with the clonal wild-type. The SCV morphology and the expression of CupA fimbriae were dependent on a functional PA1120 and morA gene both encoding a GGDEF domain. Overexpression of the GGDEF domain protein PA1120 complemented the PA1120 and the morA mutant with respect to CupA fimbriae expression. In agreement with these findings, overexpression of the EAL domain containing phenotypic variance regulator (PvrR) in the SCV resulted in a decreased intracellular level of c-di-GMP, a reduced ...
Many of the virulence factors produced by the opportunistic human pathogen Pseudomonas aeruginosa are quorum-sensing (QS) regulated. Among these are rhamnolipids, which have been shown to cause lysis of several cellular components of the human immune system, e.g. monocyte-derived macrophages and polymorphonuclear leukocytes (PMNs). We have previously shown that rhamnolipids produced by P. aeruginosa cause necrotic death of PMNs in vitro. This raises the possibility that rhamnolipids may function as a biofilm shieldin vivo, which contributes significantly to the increased tolerance of P. aeruginosa biofilms to PMNs. In the present study, we demonstrate the importance of the production of rhamnolipids in the establishment and persistence of P. aeruginosa infections, using an in vitro biofilm system, an intraperitoneal foreign-body model and a pulmonary model of P. aeruginosa infections in mice. Our experimental data showed that a P. aeruginosa strain, unable to produce any detectable ...
Purpose of reviewRecent articles of clinical interest on Pseudomonas aeruginosa respiratory tract infections including CAP, nosocomially-acquired pneumonia, particularly in the ventilated patient, and chronic infections in cystic fibrosis patients are reviewed.Recent findingsThe growing importance o
Los mecanismos innatos y adquiridos de resistencia a los antibióticos en Pseudomonas representan un reto para los médicos que buscan una quimioterapia oportuna y eficaz. Esto es par- ticularmente importante en las áreas de cuidados intesnsivos de los hospitales. Este estudio está dirigido a lograr una comprensión a nivel molecular de dos de los más importantes mecanismos de resistencia a los fármacos en Pseudomonas aeruginosa. Cien aislados clínicos de Pseudomonas aeruginosa se obtuvieron de un hospital de tercer nivel en Quito, Ecuador. Se analizó la expresión de ampC y oprD mediante PCR cuantitativa en tiempo real. Se realizó una comparación entre los perfiles de expresión ampC y oprD y los fenotipos obtenidos en la prueba de susceptibilidad antimicrobiana (AST), con más del 50% de los aislados con perfiles concordantes para la expresión ampC y oprD. Nuestros resultados sugieren que la expresión ampC y oprD podría proporcionar información útil sobre mecanismos de resistencia ...
Pseudomonas aeruginosa Serotype 2B antibody LS-C538938 is an FITC-conjugated mouse monoclonal antibody to pseudomonas aeruginosa Pseudomonas aeruginosa Serotype 2B. Validated for ELISA.
Cluster II che Genes from Pseudomonas aeruginosa Are Required for an Optimal Chemotactic Response: Pseudomonas aeruginosa, a γ-proteobacterium, is motile by mea
Haji SH. Detection of Biofilm Formation in Pseudomonas aeruginosa Isolates from Clinical Specimens. Zanco J Pure Appl Sci. 2018; 30[4]:83-89. doi: https://doi.org/10.21271/ZJPAS.30.4.9 Saha S, Devi KM, Damrolien S, Devi KS, . K, Sharma KT. Biofilm production and its correlation with antibiotic resistance pattern among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital in north-east India. Int J Adv Med. 2018;5[4]:964. doi: http://dx.doi.org/10.18203/2349-3933.ijam20183129 Vallés J, Mariscal D, Cortés P, Coll P, Villagrá A, Díaz E, et al. Patterns of colonization by Pseudomonas aeruginosa in intubated patients: A 3-year prospective study of 1,607 isolates using pulsed-field gel electrophoresis with implications for prevention of ventilator-associated pneumonia. Intensive Care Med. 2004; 30[9]:1768-1775. doi: https://doi.org/10.1007/s00134-004-2382-6. Gales AC, Jones RN, Turnidge J, Rennie R, Ramphal R. Characterization of Pseudomonas aeruginosa Isolates: Occurrence Rates, ...
Pseudomonas aeruginosa is an ubiquitous organism. Its ability to survive on minimal nutritional requirements and to tolerate a variety of physical conditions allows its persistence in both community and hospital settings [12]. P. aeruginosa is a serious therapeutic challenge for treatment of both community-acquired and nosocomial infections, due to the ability of this microorganism to develop resistance to multiple classes of antibacterial agents, even during the course of therapy [13, 14]. The increasing frequency of MDR or XDR P. aeruginosa strains is of concern as effective antimicrobial options are limited [15, 16]. Moreover, only a few new antibiotics are currently under development [6]. An increase in MDR bacterial infections among companion animals has been documented in multiple veterinary hospital settings [17]. This is of particular importance due to the risk of transmission to humans and other companion animals in close contact with infected animals, even because in our countries the ...
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide Academic Article ...
Anti Pseudomonas aeruginosa Serotype 8 Antibody, clone 1017/87 , Mouse Anti-Bacterial Monoclonal Antibody validated in WB (ABD12646), Abgent
Prime Journal of Microbiology Research (PJMR) ISSN: 2251-1261. susceptible and P. aeruginosa the least. Antibiotic use is suggested to be a major risk factor for.. chromID ™ P.aeruginosa Chromogenic medium for direct ID of Pseudomonas aeruginosa. Deliver rapid direct identification of Pseudomonas aeruginosa to contribute to.chromID™ P.aeruginosa Chromogenic medium for direct ID of Pseudomonas aeruginosa. Deliver rapid direct identification of Pseudomonas aeruginosa to contribute to.RESEARCH ARTICLE Open Access Screening of Lactobacillus spp. for the prevention of Pseudomonas aeruginosa pulmonary infections Youenn Alexandre1, Rozenn Le Berre1,2*.tetracycline, Tetracycline is an antibiotic used to treat a number of bacterial infections. It is commonly used to treat acne and rosacea. Historically it was.Original article Antibiotic resistance and virulence properties of Pseudomonas aeruginosa strains from mechanically ventilated patients with pneumonia in intensive ...
RESULTS: As a result of the antibiotic resistance analysis, 11 different antibiotypes for Hospital 1 and Hospital 3, while 6 different antibiotypes for Hospital 2 were determined. The highest incidence of MDR strains was observed in Hospital 1. It was found that MDR strains were frequently isolated from patients who underwent surgical interventions or patients in the intensive care units. As a result of genotyping, 9 different genotypes were determined in Hospital 1, 7 in Hospital 2, and 17 in Hospital 3. There was no significant correlation between the antibiotypes and genotypes. A clonal relationship between the MDR strains that were isolated from both the same service and from different services was observed in Hospital 1. These findings support the hypothesis that the strains are spread within the hospital via cross or horizontal transmission through hospital employees or medical instruments. According to Simpsons diversity index, the RAPD-PCR methods discrimination power was found as 0.92 ...
TY - JOUR. T1 - Slime production a virulence marker in Pseudomonas aeruginosa strains isolated from clinical and environmental specimens. T2 - A comparative study of two methods. AU - Prasad, S. Vishnu. AU - Ballal, Mamatha. AU - Shivananda, P. G.. PY - 2009/4/1. Y1 - 2009/4/1. N2 - Detection of slime in Pseudomonas aeruginosa can be useful in understanding the virulence of this organism. Here, comparative studies of two phenotypic methods using the tube method and the spectrophotometric method for slime production from 100 clinically and 21 environmentally significant isolates of P. aeruginosa were performed. A total of 68 isolates were positive by either of the tests whereas only 34 were positive by both the tests. The tube method detected slime significantly in more number of isolates than the spectrophotometric method. The tube test was found to be superior to the spectrophotometric method in ease of performance, interpretation and sensitivity. Among the clinical isolates, systemic isolates ...
BioAssay record AID 164894 submitted by ChEMBL: In vitro antibacterial activity against AZT resistant Pseudomonas aeruginosa 69 was determined.
BioAssay record AID 164900 submitted by ChEMBL: In vitro antibacterial activity against IPM resistant Pseudomonas aeruginosa 56 was determined.
An organism of concern, Pseudomonas aeruginosa is a water-loving bacteria that works and builds biofilms with other threatening bacteria. Understanding that disinfection alone will not rid an engineered water system of bacteria means we need to look toward biofilm-resistant material and disinfection at the source of use as opposed to where the water enters the building.. Antibiotic Resistance of Pseudomonas aeruginosa in Pneumonia at a Single University Hospital Center in Germany over a 10-Year Perioddetermines that "while P. aeruginosa and MDR P. aeruginosa were resistant to a variety of commonly used antibiotics, they were not resistant to colistin in the few isolates recovered from patients with pneumonia.". Inhibition of Aspergillus fumigatus and Its Biofilm by Pseudomonas aeruginosa Is Dependent on the Source, Phenotype and Growth Conditions of the Bacterium reports that "Aspergillus fumigatus (Af) and Pseudomonas aeruginosa (Pa) are leading fungal and bacterial pathogens, respectively, in ...
Plasma ferritin is an important extracellular iron storage molecule, whose concentration increases drastically in cancer and infection. During infection, the pathogen usurps host iron for its survival and pathogenicity; hence, maintenance of the plasma ferritin level during infection is a crucial host defence mechanism. In this study, the horseshoe crab plasma ferritin complex was purified, characterized, and its involvement in innate immune defence was investigated. The plasma ferritin appears as a 21-kDa subunit on SDS-PAGE. Full-length ferritin-H cDNAs (CrFer-H1 and CrFer-H2) were cloned. Analysis of the 5′ UTR indicates the existence of a functional iron-response element, suggesting that both the CrFer-H genes may be post-transcriptionally regulated. Northern analysis shows that the CrFer-H is ubiquitously expressed. Within 3 h of lipopolysaccharide challenge, the gene is up-regulated by > 12-fold. In contrast, iron-loading did not result in any significant change. When challenged with ...
Author Summary Pathogens face a hostile and often novel environment when infecting a new host, and adaptation to this environment can be critical to a pathogens survival. The genetic basis of pathogen adaptation is in turn important for treatment, since the consistency with which therapies succeed may depend on the extent to which a pathogen adapts via the same routes in different patients. In this study, we investigate adaptation of the bacterium Pseudomonas aeruginosa to laboratory conditions that resemble the lungs of cystic fibrosis patients and to quinolone antibiotics. We find that a handful of genes and genetic pathways are repeatedly involved in adaptation to each condition. Nonetheless, other, less common mutations can play important roles in determining fitness, complicating strategies aimed at reducing the prevalence of antibiotic resistance.
Author Summary Pathogens face a hostile and often novel environment when infecting a new host, and adaptation to this environment can be critical to a pathogens survival. The genetic basis of pathogen adaptation is in turn important for treatment, since the consistency with which therapies succeed may depend on the extent to which a pathogen adapts via the same routes in different patients. In this study, we investigate adaptation of the bacterium Pseudomonas aeruginosa to laboratory conditions that resemble the lungs of cystic fibrosis patients and to quinolone antibiotics. We find that a handful of genes and genetic pathways are repeatedly involved in adaptation to each condition. Nonetheless, other, less common mutations can play important roles in determining fitness, complicating strategies aimed at reducing the prevalence of antibiotic resistance.
Resistance to extended-spectrum cephalosporins complicates treatment of Pseudomonas aeruginosa infections. To elucidate risk factors for cefepime-resistant P. aeruginosa and determine its association with patient death, we conducted a case-control study in Philadelphia, Pennsylvania. Among 2,529 patients hospitalized during 2001-2006, a total of 213 (8.4%) had cefepime-resistant P. aeruginosa infection. Independent risk factors were prior use of an extended-spectrum cephalosphorin (p<0.001), prior use of an extended-spectrum penicillin (p = 0.005), prior use of a quinolone (p<0.001), and transfer from an outside facility (p = 0.01). Among those hospitalized at least 30 days, mortality rates were higher for those with cefepime-resistant than with cefepime-susceptible P. aeruginosa infection (20.2% vs. 13.2%, p = 0.007). Cefepime-resistant P. aeruginosa was an independent risk factor for death only for patients for whom it could be isolated from blood (p = 0.001). Strategies to counter its
Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring resistance to common antibiotics. There is an urgent need to develop antimicrobial agents against MDR Pseudomonas aeruginosa. Here we report a 27-mer peptide polymer
Wright, Laura, Turton, Jane F., Hopkins, Katie L, Livermore, David and Woodford, Neil (2015) Genetic environment of metallo-β-lactamase genes in Pseudomonas aeruginosa isolates from the UK. Journal of Antimicrobial Chemotherapy, 70 (12). pp. 3250-3258. ISSN 0305-7453 ...
Looking for Pseudomonas aeruginosa? Find out information about Pseudomonas aeruginosa. An opportunistic pathogen that is the most significant cause of hospital-acquired infections, particularly in predisposed patients with metabolic,... Explanation of Pseudomonas aeruginosa
The present study is a comparison of two different schedules of early eradication regimens of inhaled antibiotics associated with oral ciprofloxacin in the treatment of initial P aeruginosa infection. No superiority of the treatment under study was demonstrated when compared with the reference treatment. A follow-up conducted using three cultures per patient over 6 months showed no differences between the two arms in relation to the period in which patients remained P aeruginosa free. Patients previously treated with early eradication treatment had the same microbiological outcome compared with patients with first-ever infection. Early eradication treatment is associated with an increase in S maltophilia in the airways. The high percentage of patients receiving intervention considering the number assessed for eligibility indicates treatment acceptability. The dropout percentage was due more to the lack of compliance with microbiological follow-up than to the treatment itself.. A large number of ...
TY - JOUR. T1 - Application of WGS data for O-specific antigen analysis and in silico serotyping of Pseudomonas aeruginosa isolates. AU - Thrane, Sandra Wingaard. AU - Taylor, Véronique L.. AU - Lund, Ole. AU - Lam, Joseph S.. AU - Jelsbak, Lars. PY - 2016. Y1 - 2016. N2 - Accurate typing methods are required for efficient infection control. The emergence of whole genome sequencing (WGS) technologies has enabled the development of genomics-based methods applicable for routine typing and surveillance of bacterial pathogens. In this study, we developed the Pseudomonas aeruginosa serotyper (PAst) program, which enabled in silico serotyping of P. aeruginosa isolates using WGS data. PAst has been made publically available as a web-service, and aptly facilitate high-throughput serotyping analysis. The program overcomes critical issues such as the loss of in vitro typeability often associated with P. aeruginosa isolates from chronic infections, and quickly determines the serogroup of an isolate based ...
Pseudomonas aeruginosa, a gram-negative nonfermenting bacillus, is a much-feared pathogen. The organism is common in the environment, especially in water, even contaminating distilled water; it is also an important cause of infections associated with
Mouse monoclonal Pseudomonas aeruginosa serotype 9 antibody [95/159] validated for ELISA, ICC/IF. Immunogen corresponding to tissue, cells or virus
The ability of culture filtrate (CF) of two laboratory Pseudomonas aeruginosa strains to inhibit delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice has been studied. It was shown that intraperitoneal injection of native CF of the strains did not affect the level of DTH. However, redox treated CF expressed the immunosuppressive activity. Gel filtration of redox activated CF through Sephadex G-200 showed that CF contains three immunosuppressive components differing by their molecular weight and specificity. All components contained lipid group and O-polysaccharide chains that indicated their lipopolysaccharide (LPS) nature. These experiments show that laboratory P. aeruginosa strains have three LPS components but not all of them display the immunosuppressive activity.. ...
Vaccins pour la prévention de linfection par la Pseudomonas aeruginosa dans les cas de mucoviscidose. La mucoviscidose est une maladie héréditaire dans laquelle un mucus épais est secrété dans les poumons. La Pseudomonas aeruginosa et dautres bactéries sont responsables dinfections pulmonaires durables qui causent des dommages irréversibles aux poumons. Des vaccins visant à réduire linfection par la Pseudomonas aeruginosa ont été développés et il est important de savoir si la vaccination est capable de prévenir linfection du poumon. Nous avons recherché des essais contrôlés randomisés et avons inclus trois essais impliquant respectivement 483, 476 et 37 patients. Aucune donnée nétait disponible pour lun des grands essais, qui navait pas été publié. Dans lautre grand essai et dans le petit essai, le risque de contracter une infection chronique navait pas diminué. Dans le grand essai, le décès dun patient avait été signalé durant la période dobservation. ...
Read "Conserved genomes of ΦKMV-like bacteriophages (T7 supergroup) active on Pseudomonas aeruginosa, Russian Journal of Genetics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
One of the key findings of this study is that SCFM2 aggregates are mostly clonal and display a range of sensitivities to 3OC12-HSL (Fig. 3, Table 1, Table S1, and Datasets S1 and S2). From a population level, the response to increasing 3OC12-HSL is graded with a maximum of ∼80% of aggregates initiating QS when exposed to a 5-µM signal (Fig. S4A). The lack of complete (100%) response to added signal could be biologically relevant or a result of the stringent parameters we used to classify cells as QS+. We suggest the former, because overexpression of lasR increased the sensitivity of P. aeruginosa to 3OC12-HSL levels below 5 µM, but did not increase the maximum response (Fig. S4B). Thus, it is likely that those cells may simply be "blind" to biologically relevant levels of signal (between 0.5 and 1.0 µM). Of course, these nonresponsive cells could be dead or dormant "persisters," although they are at least grossly structurally intact as they can be identified by the presence of intracellular ...
The observed discrepancy between caregiver- and patient-rated quality of life for persons with dementia was largely predicted by the quality of the caregiver-patient relationship. Beneficial effect of adjunctive azithromycin in treatment of mucoid Pseudomonas aeruginosa pneumonia in the murine model. Mandibular cysts may require enucleation, resulting in large cavities compromising mandibular strength and functions.. A mine blast causes extensive injuries and psychological trauma. Among the automated alignments, there was a strong what is augmentin positive relationship between the WOOF score and similarity to the reference alignment. We have modified the theoretical model by Gor and Neimark1 to predict the sorption-induced deformation of (partly) filled porous samples.. Patients with a histologic diagnosis of high-grade glioma and radiographic evidence of tumor progression after standard surgery, radiation, and chemotherapy were eligible for the study. Here we review our current understanding ...
Read "Comparisons of the Genomes of New Giant Phages Isolated from Environmental Pseudomonas aeruginosa Strains of Different Regions, Russian Journal of Genetics" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Pseudomonas aeruginosa ATCC ® 47085D-5™ Designation: Genomic DNA from Pseudomonas aeruginosa strain PAO1-LAC TypeStrain=False Application:
Penicillin-binding protein 3 (PBP3) of Pseudomonas aeruginosa is the primary target of beta-lactams used to treat pseudomonas infections. Meanwhile, structure change and overproduction of PBP3 play important roles in the drug resistance of P. aeruginosa. Therefore, studies on the gene and structure of PBP3 are urgently needed. P. aeruginosa CMCC 10104 is a type culture strain common used in China. However, there is no report on its genomic and proteomic profiles. In this study, based on ftsl of P. aeruginosa PAO1, the gene encoding PBP3 was cloned from CMCC 10104. A truncated version of the ftsl gene, omitting the bases encoding the hydrophobic leader peptide (amino acids 1-34), was amplified by PCR. The cloned DNA shared 99.76% identity with frsl from PAO1. Only four bases were different (66 C-A, 1020 T-C, 1233 T-C, and 1527 T-C). However, there were no differences between their deduced amino acid sequences. The recombinant PBP3 (rPBP3), containing a 6-histidine tag, was expressed in ...
What did you do?. We used existing molecular tests to identify bacteria in samples, as well as designing some new rapid tests. We tried different techniques to extract DNA from respiratory samples, and then tried all the tests to find the best combinations. Our tests will give a positive result if Pseudomonas aeruginosa is present, and tell you if it is the Liverpool Epidemic Strain, the most common transmissible strain in the UK. We trialled these tests on hundreds of samples of sputum, cough swabs and bronchoalveolar lavage fluid (fluid put into a small area of lung via bronchoscopy, and then re-collected for examination). We did this alongside the current diagnostic tests(bacterial cultures), and compared the results to see if we could detect more Pseudomonas positive samples using our rapid methods.. ...
Bacterial infections due to Pseudomonas continue to cause deaths of newborn infants, children and adults. Infant Deaths In October, three infants died and five others became seriously ill from a Pseudomonas infection at the neonatal intensive care unit of a Geisinger Medical Center in Pennsylvania. A New York Times article on the Pennsylvania hospital outbreak quoted…. ...
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Pseudomonas aeruginosa ATCC ® 9027D-5™ Designation: Genomic DNA from Pseudomonas aeruginosa strain R. Hugh 813 TypeStrain=False Application:
The Gram-negative opportunistic pathogen Pseudomonas aeruginosa ubiquitously inhabits soil and water habitats and also causes serious, often antibiotic resistant, infections in immunocompromised patients (e.g. cystic fibrosis). This versatility is mediated in part by a large repertoire of two-compon …
Background: Pseudomonas aeruginosa is the most common gram-negative bacteria isolated from intensive care units (ICUs) across the United States. Nosocomial infections with P. aeruginosa have been strongly associated with mortality rates of 60%. Monte Carlo simulations have demonstrated that extended infusion (EI: 4-hour infusion) cefepime achieves a higher cumulative fraction of response against P. aeruginosa. The purpose of this study was to compare clinical outcomes between traditional infusion (TI: 30-minute infusion IV) and EI cefepime administration regimens of ICU patients for the management of P. aeruginosa bacteremia or pneumonia. Methods: This retrospective, multi-center, cohort review compared EI to TI cefepime to determine if EI cefepime improved outcomes. The primary objective is to determine the 28-day mortality rate of EI compared to TI cefepime for ICU patients with a documented P. aeruginosa bacteremia or pneumonia. Secondary objectives included length of stay (LOS) in the ICU, ...
Because bacteria cause Pseudomonas aeruginosa infections, doctors treat them with antibiotics, reports WebMD. Sometimes doctors have difficulty selecting the proper antibiotics, as the bacteria...
The message said the girl suffered acute septicemia and pneumonia after catching the flu.. Laboratory tests on Wednesday showed that the girl was infected with pseudomonas aeruginosa, one of 12 families of bacteria listed by the World Health Organization as antibiotic-resistant "priority pathogens", Radio Television Hong Kong reported.. Serious pseudomonas infections usually occur in people in a hospital or with weakened immune systems.. Kwok Ka-ki, a lawmaker in the medical functional constituency, urged health authorities to check and disinfect the school, clinic and hospital that the girl visited and to find the source of the bacteria, Apple Daily reported. ...
... include tuberculosis, mycobacterium, histoplasmosis, blastomycosis and bronchiectasis. They are treatable when diagnosed early.
Bacteria that infect the lungs of cystic fibrosis sufferers lose their ability to work together, becoming more selfish and less cooperative the longer the infection, say scientists.
P. aeruginosa rarely causes disease in healthy humans. It is usually linked with patients whose immune system is compromised by diseases or trauma. It gains access to these patients tissues through the burns, for the burn victims, or through an underlying disease, like cystic fibrosis. First, P. aeruginosa adheres to tissue surfaces using its flagellum, pili, and exo-S; then, it replicates to create infectious critical mass; and lastly, it makes tissue damage using its virulence factors (21). Since the powerful exotoxins and endotoxins released by P. aeruginosa during bacteremias continue to infect the host even after P. aeruginosa has been killed off by antibiotics, acute diseases caused by P. aeruginosa tend to be chronic and life-threatening. Furthermore, with the exception of the cystic fibrosis strain, most P. aeruginosa strains that attack compromised patients tend to be nonmucoid (2). And even though a small amount of patients infected by P. aeruginosa developed severe sepsis with ...
P. aeruginosa rarely causes disease in healthy humans. It is usually linked with patients whose immune system is compromised by diseases or trauma. It gains access to these patients tissues through the burns, for the burn victims, or through an underlying disease, like cystic fibrosis. First, P. aeruginosa adheres to tissue surfaces using its flagellum, pili, and exo-S; then, it replicates to create infectious critical mass; and lastly, it makes tissue damage using its virulence factors (21). Since the powerful exotoxins and endotoxins released by P. aeruginosa during bacteremias continue to infect the host even after P. aeruginosa has been killed off by antibiotics, acute diseases caused by P. aeruginosa tend to be chronic and life-threatening. Furthermore, with the exception of the cystic fibrosis strain, most P. aeruginosa strains that attack compromised patients tend to be nonmucoid (2). And even though a small amount of patients infected by P. aeruginosa developed severe sepsis with ...
Pseudomonas aeruginosa can cause severe sight- and life-threatening disease. Epithelial lined surface tissues such as the eye, the skin and the airways are the...
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Pseudomonas aeruginosa PvdE protein: required for pyoverdine biosynthesis in Pseudomonas aeruginosa; amino acid sequence in first source; GenBank U07359
Cefsulodin: A pyridinium-substituted semisynthetic, broad-spectrum antibacterial used especially for Pseudomonas infections in debilitated patients.
We present a case of an elderly non-smoking gentleman who, since 2005, had been admitted multiple times for recurrent episodes of shortness of breath, wheeze, cough and sputum. The patient was treated as exacerbations of chronic obstructive pulmonary disease (COPD) and/or lower respiratory tract infections. Bronchoscopy was done which revealed multiple hard nodules in the trachea and bronchi with posterior tracheal wall sparing. Biopsies confirmed this as tracheopathia osteochondroplastica (TO). He had increasing frequency of admission due to methicillin-resistant Staphylococcus aureus and pseudomonas infections, which failed to clear despite intravenous, prolonged oral and nebulised antibiotics. The patient developed increasing respiratory distress and respiratory failure. The patient died peacefully in 2012. This case report highlights the typical pathological and radiological findings of TO and the pitfalls of misdiagnosing patients with recurrent chest infections as COPD ...
Pseudomonas aeruginosa remains a serious pathogen for specific cohorts of patients where chronic infection is a poor prognostic indicator, such as those with cystic fibrosis, burn wounds or those who are immunocompromised. Significant disease burden is associated with a diverse spectrum of both nosocomial and community-acquired infections. To date, vaccines against P. aeruginosa have shown limited and often conflicting efficacy data, especially against heterologous strains, which are increasingly identified as co-colonisers of biofilms. While few studies have gone beyond Phase II clinical trials, a particular concern is the ability of P. aeruginosa to evade the immune system while provoking an immune response that contributes to the destructive nature of infection. Therefore, vaccine development needs to focus on preventing attachment and colonisation, as well as preventing conversion to a mucoid phenotype that is characteristic of the chronic condition that promotes pathology ...
When I look at your website in Firefox, clindamycin phosphate gel usp price it looks fine but when opening in Internet Explorer, it has some overlapping! Cipro no es procesado por el hígado, clindamycin phosphate gel usp price esto significa que no interactúa con los ARVs. Unfortunately, many pseudomonas infections are becoming more difficult to treat! So kann dann Cialis Kautabletten auf einfache Art gewisse Probleme aus der Welt schaffen? We made encouraging progress across the main therapy areas and delivered strong growth in China? Over go orbicularly the last several years Ive used Retin A for a month or two but about six months ago I decided to get serious? Shortness of breath is not a side effect commonly associated with Zestril! Le pubblicità ingannevoli ci promettono, clindamycin phosphate gel usp price anche troppo spesso, effetti benefici e straordinari con la semplice assunzione di sostanze naturali. Bereits drei Jahre später wurde es am Menschen angewendet? More specifically, ...
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Bacteria P. aeruginosa is a Gram-negative aerobic bacillus. It`s a human pathogen that is widespread in nature. It`s called an opportunistic pathogen because it causes disease only in people with imparied immunity. P. aeruginosa spreads easily in humid environment and has elaborate mechanisms for adhering to solid surfaces and establishing biofilms so it`s important to find out more about its resistance and survival in different conditions. P. aeruginosa was isolated and biochemically confirmed from different water samples. We selected 10 isolates and monitored their survival in sterile water over a period of 28 days. All isolates survived during the examined period. P. aeruginosa from ship`s tank survived the longest, and the shortest survival had P. aeruginosa from brackish water from river Cetina. Other isolates showed even survival rate. P. aeruginosa has various mechanisms that helps her to survive in different conditions , especially those with a lack of nutrition ...
Background and Objectives: Pseudomonas aeruginosa is one of the multi-drug resistant pathogens and a cause of opportunistic neusocomial infections. Different methods have been used for investigating genetic diversity of P. aeruginosa. rep-PCR typing has been introduced as a rapid and low-cost method with high discriminatory power. The aim of this study was ...
Project Description The project is focused on how bacteria sense and transduce environmental signals in order to adapt to and survive in certain niches. Pseudomonas aeruginosa is a highly versatile bacterium and a major cause of the poor clinical outcome of cystic fibrosis patients. The goal of the project is to increase our understanding on…
Southampton research has shown that nitric oxide can greatly improve the effects of antibiotics in tackling the chronic lung infections endured by cystic fibrosis patients.
Pseudomonas aeruginosa is one of the most intractable human pathogens that pose serious clinical challenge due to extensive prevalence of multidrug-resistant clinical isolates. Armed with abundant virulence and antibiotic resistance mechanisms, it is a major etiologic agent in a number of acute and …
Researchers from the University of California San Diego have identified a potential new target against Pseudomonas aeruginosa infections - which could be applied to help treat all gram-negative infections. It was found that by interfering with the Mla pathway in P. aeruginosa, the bacteria became more permeable, and more susceptible to immune components. P. aeruginosa, … Read more. ...
In particular we have been recently trying to understand adaptive lifestyles. Pseudomonas aeruginosa has evolved complex interwoven regulatory mechanisms that permit adaptation to a wide variety of circumstances and environments (including antibiotic, nutritional and other environmental stresses, and particular growth states such as swarming and surfing motility and biofilm formation that are thought to represent distinct lifestyles in the body). We have addressed these issues using the 3 comprehensive arrayed mutant libraries available to us, as well as global transcriptional profiling (RNA-Seq). Generally speaking this reveals massive complexity. For example, swarming motility is a complex form of surface motility triggered by semi-viscous medium and a weak nitrogen source (such as amino acids). In swarming motility we identified more than 1600 genes (85 regulators) that were dysregulated under swarming conditions including upregulation of most virulence factors, alterations in metabolism and ...
Growth parameters of Pseudomonas aeruginosa were quantified based on steady-state concentrations, utilization rates of glucose and dissolved oxygen, and microorganism concentration in a chemostat that was operated at 25 °C, pH 7.2, and an agitation rate 350 rpm. The results showed that the microbial growth was limited by the concentration of glucose and the concentration of oxygen. A dual-substrate, Tessier growth kinetics for oxygen and glucose, was in good agreement with the experimental data using the following biokinetic parameters: max=0.29 h-1, Kg=26.9 mg/l, Ko=1.18 mg/l, Yx/g=0.628 g microorganism/g glucose and, Yx/o=0.635 g microorganism/g oxygen. Maintenance factors for glucose and oxygen were: mg=0.0078 g glucose consumed/g microorganism h, and mo=0.014 g oxygen consumed/g microorganism h ...
Maejima, K; Urano, T; Itoh, K; Fujiwara, K; and Homma, J Y., "Methods for detection and isolation of pseudomonas aeruginosa in mouse breeding colonies. (jap. With eng. Summ.)" (1972). Subject Strain Bibliography 1972. 1247 ...
Pseudomonas aeruginosa (o bacil piociànic, bacil del pus blau, bacil del pus verd) és un bacteri comú que causa malalties en animals i plantes, incloent-hi els humans. Es troba als sòls, aigua, flora de la pell, i molts ambients humans de tot el món. Ha colonitzat molts ambients naturals i artificials, ja que aquest bacteri pot viure no només en atmosferes normals sinó també en atmosferes hipòxiques. Com aliment fa servir un gran rang de materials orgànics, la seva versatilitat el permet infectar teixits danyats o persones amb el sistema immunitari reduït. Els símptomes de les infeccions són inflamació generalitzada i sèpsia. Si afecten òrgans com el pulmó, el tracte urinari i els ronyons el resultat pot ser fatal.[1] Com que prospera en moltes superfícies també es pot trobar aquest bacteri en lequipament mèdic, incloent-hi catèters, causant infeccions encreuades en hospitals i clíniques. També pot descompondre hidrocarburs i sha usat en la indústria petroliera.[2][3] ...
Potential drug could ease impact of bacterial lung infections in cystic fibrosis patients, tests suggest | ScienceDaily - Health and Medicine News | 10/14/2014
Harrison, Freya and McNally, Alan and da Silva, Ana C. and Heeb, Stephan and Diggle, Stephen P. (2017) Optimised chronic infection models demonstrate that siderophore cheating in Pseudomonas aeruginosa is context specific. ISME Journal . ISSN 1751-7362 (In Press) Darch, Sophie E. and McNally, Alan and Harrison, Freya and Corander, Jukka and Barr, Helen L. and Paszkiewicz, Konrad and Holden, Stephen and Fogarty, Andrew W. and Crusz, Shanika A. and Diggle, Stephen P. (2015) Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection. Scientific Reports, 5 . 7649/1-7649/12. ISSN 2045-2322 ...
Smith, Roger S., Matthew C. Wolfgang, and Stephen Lory. "An Adenylate Cyclase-Controlled Signaling Network Regulates Pseudomonas aeruginosa Virulence in a Mouse Model of Acute Pneumonia." Infection and Immunity 72.3 (2004): 1677-1684. Web. 01 June. 2020. ...
PURIFIKASI DAN KARAKTERISTIK PROTEASE DARI PATOGEN Pseudomonas aeruginosa[Purification and Charaterization of Protease from Pathogenic Bacteria Pseudomonas aeruginosa]Ace Baekhari 1), Maggy T. Suhartono 2), Nurheni Sri Palupi 2) dan Tati Nurhayati 3)1) Program Studi Teknologi Hasil Perikanan, Fakultas Pertanian Universitas Sriwijaya2) Departemen Ilmu dan Teknologi Pangan, Institut Pertanian Bogor3) Departemen Teknologi Hasil Perairan, Institut Pertanian BogorDiterima…
Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, Miyata S, Diggins LT, He J, Saucier M, Déziel E, Friedman L, Li L, Grills G, Montgomery K, Kucherlapati R, Rahme LG, Ausubel FM. Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol. 2006; 7(10):R90 ...