TY - JOUR. T1 - Up-regulation of soluble Axl and Mer receptor tyrosine kinases negatively correlates with Gas6 in established multiple sclerosis lesions. AU - Weinger, Jason G.. AU - Omari, Kakuri M.. AU - Marsden, Kurt. AU - Raine, Cedric S.. AU - Shafit-Zagardo, Bridget. PY - 2009/7. Y1 - 2009/7. N2 - Multiple sclerosis is a disease that is characterized by inflammation, demyelination, and axonal damage; it ultimately forms gliotic scars and lesions that severely compromise the function of the central nervous system. Evidence has shown previously that altered growth factor receptor signaling contributes to lesion formation, impedes recovery, and plays a role in disease progression. Growth arrest-specific protein 6 (Gas6), the ligand for the TAM receptor tyrosine kinase family, consisting of Tyro3, Axl, and Mer, is important for cell growth, survival, and clearance of debris. In this study, we show that levels of membrane-bound Mer (205 kd), soluble Mer (⌈150 kd), and soluble Axl (80 kd) were ...

Buy Anti-MerTK (c-MER, c-Mer Proto-oncogene Tyrosine Kinase, MER, MER Receptor Tyrosine Kinase, MERK, ME, item number: M2995-05.100 from United States Biological at Biomol!

Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Tolllike receptor activation. Previously, we found that lung Mer protein expression decreased after lipopolysaccharide (LPS) treatment due to enhanced Mer cleavage. The purpose of the present study was to examine whether pharmacologically restored membrane-bound Mer expression upregulates the Mer signaling pathways and suppresses lung inflammatory responses. Pretreatment with the ADAM17 (a disintegrin and metalloproteinase-17) inhibitor TAPI-0 (tumor necrosis factor alpha protease inhibitor-0) reduced LPS-induced production of soluble Mer protein in bronchoalveolar lavage (BAL) fluid, restored membrane-bound Mer expression, and increased Mer activation in alveolar macrophages and lungs after LPS treatment. TAPI-0 also enhanced Mer downstream signaling, including phosphorylation of protein kinase b, focal adhesion kinase, and signal transducer and activator of ...

Although TGF-β has been shown to stimulate the growth of many fibroblast cell lines, only murine AKR-2B and NRK fibroblasts undergo anchorage-independent growth in response to TGF-β (29, 37). So far, the intracellular signaling pathway that mediates this transforming activity in the two fibroblast cell lines has not been clearly defined. Here we showed that SnoN is a critical mediator of TGF-β-induced transformation in AKR-2B and NRK fibroblast cells. TGF-β, through the action of the Smad2/Smad4 complex, induces a strong and prolonged upregulation of snoN expression in these fibroblast cells that lasts for more than 8 to 24 h. This sustained activation of snoN expression may be necessary for the anchorage-independent growth of these fibroblasts in response to TGF-β1, since reduction of snoN expression by siRNA abolished TGF-β-induced transformation of AKR-2B cells and shortening of the duration of snoN induction by a pharmacological inhibitor markedly impaired TGF-β-induced transformation ...

Cirrhosis of the liver is a condition with a high mortality and raising prevalence worldwide. Infectious complications are highly frequent and independent predictors of outcome in patients with cirrhosis - being the leading cause of decompensation, acute-on-chronic liver failure (ACLF) and death. There is no treatment option other than transplantation, applicable at early stages and to only a minority of patients. Susceptibility to infection has been documented in patients with cirrhosis and has been attributed to immuneparesis and monocyte dysfunction in the state of decompensation and liver failure. The underlying mechanisms are incompletely understood. Development of targeted immunomodulatory strategies might effectively reduce infectious complications and mortality in cirrhosis. MER receptor tyrosine kinase (MERTK), expressed on monocytes/macrophages, plays a pivotal role in dampening innate immune responses. We have recently discovered and documented the role of MERTK in innate immune ...

James W. Perfield, Yunkyoung Lee, Gerald I. Shulman, Varman T. Samuel, Michael J. Jurczak, Eugene Chang, Chen Xie, Phillip N. Tsichlis, Martin S. Obin, Andrew S. Greenberg ...

Purified Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled from Creative Biomart. Recombinant Human FYN Protein, Myc/DDK-tagged, C13 and N15-labeled can be used for research.

tyrosine-protein kinase Fyn,FYN oncogene related to SRC, FGR, YES,c-fyn, fyn proto-oncogene,p59-Fyn,proto-oncogene c-Fyn,proto-oncogene tyrosine-protein kinase ...

Tcl script which is executed in the global scope if the show-help signal is received, which is normally the case if the user presses F1 or Ctrl-F1. Before evaluation the following percent strings are substituted: %w widget ...

Tcl1兔多克隆抗体(ab32813)可与人样本反应并经WB实验严格验证，被1篇文献引用。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。

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Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...

Li, Xinli, Chun Liu, Blanche C. Ip, Kang-Quan Hu, Donald E. Smith, Andrew S. Greenberg, and Xiang-Dong Wang. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. Journal of Experimental & Clinical Cancer Research 34, no. 1 (12, 2015): 1-8 ...

Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly. AP-2α is a transcription factor essential for neural crest cell migration and its mutation results in apoptosis within this cell population, as demonstrated by genetic models. We down-modulated AP-2α expression in GN-11 neurons by RNA interference and observe reduced neuron migration following the activation of a specific genetic programme including the Adhesion Related Kinase (Axl) gene. We prove that Axl is able to coordinate migration per se and by ChIP and promoter analysis we observe that its transcription is directly driven by AP-2α via the binding to one or more functional AP-2α binding sites present in its regulatory region. Analysis of migration in AP-2α null mouse embryo fibroblasts also reveals an essential role for AP-2α in cell movement via the activation of a distinct genetic programme. We show that AP-2α plays an essential role in cell

The KOMP Repository Collection is located at the MMRRC at the University of California, Davis and Childrens Hospital Oakland Research Institute. Question? Comments? For Mice, Cells, and germplasm please contact us at [email protected], US 1-888-KOMP-MICE or International +1-530-752-KOMP, or for vectors [email protected] or +1-510-450-7917 ...

TY - JOUR. T1 - Expression of c-cbl proto-oncogene is modulated during differentiation but not during induction of proliferation. AU - Mushinski, J.F.. AU - Goodnight, J.. AU - Rudikoff, E.. AU - Morse Iii, H.C.. AU - Langdon, Wallace. PY - 1994. Y1 - 1994. M3 - Article. VL - 9. SP - 2489. EP - 2497. JO - Oncogene. JF - Oncogene. SN - 0950-9232. ER - ...

HEADER TRANSFERASE 31-JAN-08 3C5L TITLE POLO-LIKE KINASE 1 POLO BOX DOMAIN IN COMPLEX WITH PPHSPT TITLE 2 PEPTIDE COMPND MOL_ID: 1; COMPND 2 MOLECULE: SERINE/THREONINE-PROTEIN KINASE PLK1; COMPND 3 CHAIN: A; COMPND 4 FRAGMENT: POLO BOX 1, POLO BOX 2, UNP RESIDUES 373-593; COMPND 5 SYNONYM: POLO-LIKE KINASE 1, PLK-1, SERINE/THREONINE- COMPND 6 PROTEIN KINASE 13, STPK13; COMPND 7 EC: 2.7.11.21; COMPND 8 ENGINEERED: YES; COMPND 9 MOL_ID: 2; COMPND 10 MOLECULE: PEPTIDE; COMPND 11 CHAIN: B; COMPND 12 ENGINEERED: YES SOURCE MOL_ID: 1; SOURCE 2 ORGANISM_SCIENTIFIC: HOMO SAPIENS; SOURCE 3 ORGANISM_COMMON: HUMAN; SOURCE 4 ORGANISM_TAXID: 9606; SOURCE 5 GENE: PLK1, PLK; SOURCE 6 EXPRESSION_SYSTEM: ESCHERICHIA COLI; SOURCE 7 EXPRESSION_SYSTEM_TAXID: 562; SOURCE 8 EXPRESSION_SYSTEM_STRAIN: ROSETTA 2; SOURCE 9 EXPRESSION_SYSTEM_VECTOR_TYPE: PLASMID; SOURCE 10 EXPRESSION_SYSTEM_PLASMID: PET28A; SOURCE 11 MOL_ID: 2; SOURCE 12 SYNTHETIC: YES KEYWDS PLK1, POLO-LIKE KINASE 1, POLO BOX DOMAIN, PHOSPHOPEPTIDE, ...

This graph shows the total number of publications written about Proto-Oncogene Proteins c-pim-1 by people in this website by year, and whether Proto-Oncogene Proteins c-pim-1 was a major or minor topic of these publications ...

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pep:known chromosome:VEGA66:10:93247414:93311135:-1 gene:OTTMUSG00000033471 transcript:OTTMUST00000084101 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Elk3 description:ELK3, member of ETS oncogene family ...

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അമേരിക്കയിൽ കണ്ടു വരുന്ന, മാർജ്ജാരവർഗ്ഗത്തിൽപ്പെടുന്ന ഒരു വലിയ ജീവിയാണ്‌ പൂമ.(പുമ)[3] ഇംഗ്ലീഷ്:Puma. ഏറ്റവും അധികം പേരുകളുള്ള മൃഗം എന്ന ഗിന്നസ് റെക്കോഡുണ്ട് ഇതിന്. കൂഗർ, പാന്തർ, പ്യൂമ, മൗണ്ടൻ ലയൺ, മൗണ്ടൻ ക്യാറ്റ് തുടങ്ങി നാൽപ്പതോളം പേരുകളിൽ അറിയപ്പെടുന്നു. കടുവ, സിംഹം, ജാഗ്വർ എന്നിവക്ക് പിന്നിലായി പുലിക്കൊപ്പം പൂച്ച കുടുംബത്തിലെ ഏറ്റവും വലിയ നാലാമത്തെ ജീവിയാണ് പൂമ. എങ്കിലും ...

Looking for online definition of AXL receptor tyrosine kinase in the Medical Dictionary? AXL receptor tyrosine kinase explanation free. What is AXL receptor tyrosine kinase? Meaning of AXL receptor tyrosine kinase medical term. What does AXL receptor tyrosine kinase mean?

Diagnosis of acute kidney injury (AKI) relies on a late marker, namely serum creatinine (SCr). New biomarkers are considered for early and sensitive detection of CIN. In particular, uNGAL has been used for early detection of AKI in the emergency department, after cardiopulmonary bypass or following CM administration.. This study will be conducted to assess the possible value of urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) as an early detector of contrast-induced nephropathy (CIN) in a large sized cohort of patients undergoing percutaneous coronary procedures (PCP) and whether or not uNGAL correlates with the volume of contrast medium (CM) used. ...

Different molecular forms of urinary neutrophil gelatinase-associated lipocalin (NGAL) have recently been discovered. We aimed to explore the nature, source and discriminatory value of urinary NGAL in

Acute kidney injury (AKI) is a devastating potential consequence of renal ischaemia and reperfusion (I-R) subsequent to severe intra-operative hypotension and fluid resuscitation. Acute tubular epithelial damage is a common early histological abnormality in this syndrome. The high mortality rate associated with AKI in dogs is attributed in part to the limitations of current diagnostic techniques that can only detect AKI in the late stages when damage is irreversible. Early detection of renal tubular injury could improve outcome and might be possible by measuring urinary neutrophil gelatinase-associated lipocalin concentration (uNGAL) in at-risk dogs.. The objectives of this study were to establish a clinically relevant canine model of renal I-R injury, and use this model to determine changes in uNGAL within three hours of initiation of injury.. A pilot study was performed to establish the severity and duration of hypotension caused by haemorrhage, and duration of reperfusion, that produced ...

TY - JOUR. T1 - Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice. AU - Mori, Katsuya. AU - Suzuki, Takeshi. AU - Minamishima, Shizuka. AU - Igarashi, Toru. AU - Inoue, Kei. AU - Nishimura, Daisuke. AU - Seki, Hiroyuki. AU - Yamada, Takashige. AU - Kosugi, Shizuko. AU - Katori, Nobuyuki. AU - Hashiguchi, Saori. AU - Morisaki, Hiroshi. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background and Aim: Because neutrophil gelatinase-associated lipocalin (NGAL) is known to provide significant bacteriostatic effects during infectious conditions, we tested the hypothesis that this protein is up-regulated and secreted into the intraluminal cavity of the gut under critically ill conditions and is thus responsible for the regulation of bacterial overgrowth. Methods: With our institutional approval, male C57BL/6J mouse (6-7weeks) were enrolled and applied for lipopolysaccharide or peritonitis model compared with naïve control. We assessed NGAL protein concentrations in intestinal lumen and ...

Neutrophil gelatinase-associated lipocalin (NGAL) is a small 25-kDa protein released from kidney tubular cells after harmful stimuli. It represents one of the most promising future biomarkers in the diagnostic field of acute kidney injury (AKI), as the increase in NGAL levels is a good predictor of a brief-term onset of AKI, notably anticipating the resulting increase in serum creatinine. However, recent studies also suggest a possible role for NGAL in chronic kidney disease (CKD). For this reason we evaluated serum (sNGAL) and urinary NGAL (uNGAL) in a cohort of CKD patients in order to verify the relationship with the severity of renal impairment. In CKD patients sNGAL, uNGAL and the fractional excretion of this protein were notably increased as compared to controls. Furthermore both sNGAL and uNGAL were correlated with serum creatinine and, inversely, with residual glomerular filtration rate (GFR): this last relationship was found to be even closer than that found between GFR and serum ...

Lipocalin-2, human recombinant protein, Neutrophil gelatinase-associated lipocalin, NGAL, p25, 25 kDa alpha-2-microglobulin-related subunit validated in (PBV10492r-10), Abgent

Neutrophil gelatinase-associated lipocalin has been used for the diagnosis, prognosis and severity assessment of AKI and has been validated in paediatric populations (where comorbidity is low) and in conditions where the timing of the insult is clear (that is cardiac surgery and so on) [20-24]. Its role in an adult ICU population has not been well validated due to the heterogeneity and uncertainty of the timing of the insult. The pathophysiology and causes of AKI in the ICU could be indigenous [25] and may differ from pre-ICU causes (low-volume state, inotropes, contrast injury and so on). This has led to problems in the design and interpretation of studies in the general adult ICU patient cohort. In this study, we sought to overcome these problems by excluding patients with pre-existing chronic kidney disease (CKD) and/or AKI and by looking at the predictive value of both urinary and plasma NGAL at different time points following admission.. We found the incidence of AKI was 30.4% (n = 59) with ...

McLean , M H , Thomson , A J , Murray , G I , Fyfe , N , Hold , G L & El-Omar , E M 2013 , Expression of neutrophil gelatinase-associated lipocalin in colorectal neoplastic progression : a marker of malignant potential? , British Journal of Cancer , vol. 108 , no. 12 , pp. 2537-2541 . https://doi.org/10.1038/bjc. ...

Abstract Elderly is the main age group affected by acute kidney injury (AKI). There are no studies that investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic elderly population. This study aimed to evaluate the efficacy of uNGAL as predictor of AKI diagnosis and prognosis in elderly septic patients admitted to ICUs. We prospectively studied elderly patients with sepsis admitted to ICUs from October 2014 to November 2015. Assessment of renal function was performed daily by serum creatinine and urine output. The level of uNGAL was performed within the first 48 hours of the diagnosis of sepsis (NGAL1) and between 48 and 96 hours (NGAL2). The results were presented using descriptive statistics and area under the receiver operating characteristic curve (AUC-ROC) and p value was 5%. Seventy-five patients were included, 47 (62.7%) developed AKI. At logistic regression, chronic kidney disease and low mean blood pressure at admission were identified as factors associated ...

One-hundred and eighty-one patients (66.1%) were men; mean age was 68.2 ± 12.2 years. Valve replacement was performed in 123, coronary artery bypass graft (CABG) in 81, valve surgery + CABG in 48, cardiac transplant in five, aorta aneurism surgery in nine, and other procedures in eight patients. ICU and hospital stays were 6.7 ± 8.1 and 15.7 ± 13.9 days, respectively. Renal replacement therapy (RRT) was required in 16 patients (5.8%) within 48 hours of ICU stay and in 28 patients (10.2%) within 43weeks. Mortality at 28 days was 2.9%. Eighty-six patients (31.4%) were diagnosed with AKI within 48 hours of surgery. Area under the ROC curve of POST uNGAL for AKI diagnosis was 0.72 (0.66 to 0.79) (P 0.0001) at an optimal cutoff value of 1803 μg/l, with 78.7% specificity, 64% sensitivity and 74.1% accuracy. uNGAL advanced diagnosis of AKI in 44 patients (51.2%), whereas diagnosis was achieved at the same time as AKI criteria in 11 patients; AKI criteria outperformed uNGAL in only 36% of cases. ...

Looking for online definition of RAB41, member RAS oncogene family in the Medical Dictionary? RAB41, member RAS oncogene family explanation free. What is RAB41, member RAS oncogene family? Meaning of RAB41, member RAS oncogene family medical term. What does RAB41, member RAS oncogene family mean?

Semantic Scholar extracted view of Neutrophil gelatinase-associated lipocalin as an early indicator for postoperative renal failure by CD Van der Marel et al.

Alt. Names/Synonyms: c-met-related tyrosine kinase; CD136; CDw136; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R; p185-Ron; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; RON; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4 ...

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), encoded by the MST1R gene, is a cell-surface receptor that binds macrophage-stimulating protein (MSP). It was previously known as RON. The precursor protein is cleaved to generate the mature form, a heterodimer of disulfide-linked alpha and beta subunits. The beta subunit of MST1R/RON is phosphorylated at tyrosine residues upon activation by MSP. MST1R/RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation, and survival at the wound site. MST1R/RON is also known as CDw136, protein-tyrosine kinase 8 (PTK8), c-met-related tyrosine kinase, macrophage-stimulating protein receptor, MSP receptor, p185-Ron, CD136, MST1R variant RON30, MST1R variant RON62, and RON variant E2E3.. ...

Macrophage stimulating 1 receptor (c-met-related tyrosine kinase), encoded by the MST1R gene, is a cell-surface receptor that binds macrophage-stimulating protein (MSP). It was previously known as RON. The precursor protein is cleaved to generate the mature form, a heterodimer of disulfide-linked alpha and beta subunits. The beta subunit of MST1R/RON is phosphorylated at tyrosine residues upon activation by MSP. MST1R/RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation, and survival at the wound site. MST1R/RON is also known as CDw136, protein-tyrosine kinase 8 (PTK8), c-met-related tyrosine kinase, macrophage-stimulating protein receptor, MSP receptor, p185-Ron, CD136, MST1R variant RON30, MST1R variant RON62, and RON variant E2E3.. ...

Subramanian Senthilkumaran, Ponniah Thirumalaikolundusubramanian, Namasivayam Elangovan Journal of Emergencies, Trauma, and Shock 2019 12(4):260-262 Backgrou

The RON receptor tyrosine kinase regulates epithelial cell homeostasis and tumorigenesis by transducing multiple signals through its functional domains. The present study was to determine the significance of the entire C-terminus in RON or its variant RON160-mediated activities related to cell motility and tumorigenesis. Analysis of protein phosphorylation revealed that elimination of the entire C-terminus significantly impairs the ligand-dependent or independent RON or RON160 phosphorylation and dimerization. Phosphorylation of downstream signaling proteins such as Erk1/2, AKT, and p38 MAP kinase was also diminished in cells expressing the C-terminus-free RON or RON160. These dysfunctional activities were accompanied with the inability of truncated RON or RON160 to mediate cytoplasmic β-catenin accumulation. Functional analysis further demonstrated that truncation of the C-terminus significantly impairs RON or RON160-mediated cell proliferation, morphological changes, and cellular migration.

SnoN is a negative regulator of TGF-β signaling and also an activator of the tumor suppressor p53 in response to cellular stress. Its role in human cancer is complex and controversial with both pro-oncogenic and anti-oncogenic activities reported. To clarify its role in human cancer and provide clinical relevance to its signaling activities, we examined SnoN expression in normal and cancerous human esophageal, ovarian, pancreatic and breast tissues. In normal tissues, SnoN is expressed in both the epithelium and the surrounding stroma at a moderate level and is predominantly cytoplasmic. SnoN levels in all tumor epithelia examined are lower than or similar to that in the matched normal samples, consistent with its anti-tumorigenic activity in epithelial cells. In contrast, SnoN expression in the stroma is highly upregulated in the infiltrating inflammatory cells in high-grade esophageal and ovarian tumor samples, suggesting that SnoN may potentially promote malignant progression through ...

TY - JOUR. T1 - The protooncogene product, PEBP2β/CBFβ, is mainly located in the cytoplasm and has an affinity with cytoskeletal structures. AU - Tanaka, Yuta. AU - Watanabe, Toshio. AU - Chiba, Natsuko. AU - Niki, Masaru. AU - Kuroiwa, Yasuyuki. AU - Nishihira, Tetsuro. AU - Satomi, Susumu. AU - Ito, Yoshiaki. AU - Satake, Masanobu. N1 - Funding Information: We thank Ms I Imamura for secretarial assistance. This investigation was supported in part by research grants from the Ministry of Education, Science and Culture of Japan, Proposal-Based Advanced Industrial Technology R&D Program, Takeda Science Foundation, The Ryoichi Naito Foundation for Medical Research, The Mochida Memorial Foundation for Medical and Pharmaceutical Research, Uehara Memorial Foundation and The Naito Foundation.. PY - 1997. Y1 - 1997. N2 - The Pebpb2/Cbfb gene encodes the non-DNA binding β subunit of the heterodimeric transcription factor, PEBP2/CBF, and has been implicated in a subtype of human acute myeloid leukemia, ...

Fingerprint Dive into the research topics of Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. Together they form a unique fingerprint. ...

555 The Macrophage-Stimulating Protein receptor aka. MSP-R or RON belongs to the c-MET family of receptor tyrosine kinases. The ligand for c-MET - Hepatocyte Growth Factor (HGF) as well as RONs ligand, MSP are members of the kringle-domain plasminogen-related protein family. As its name implies, MSP was originally found to stimulate macrophages by a variety of means. For example, addition of MSP to certain RON-expressing macrophages induced shape changes, chemotaxis, macropinocytosis and phagocytosis. RON was also found to be expressed in epithelial cells such as keratinocytes where MSP was shown to phosphorylate RON and activate a number of signaling pathways that elicited cell adhesion/motility, anti-apoptotic and proliferative responses. Within the last few years, however, over-expression of RON has been observed in several epithelial tumors and cell lines (ex. colon, breast and lung). In addition, the oncogenic potential of RON was recently demonstrated following its overexpression in ...

FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013 ...

Proto-Oncogene Proteins c-ret definition. define Proto-Oncogene Proteins c-ret. Explain Proto-Oncogene Proteins c-ret. What is Proto-Oncogene Proteins c-ret? Proto-Oncogene Proteins c-ret FAQ.

ROS1 (ROS proto-oncogene 1 , receptor tyrosine kinase), Authors: Samuel J Klempner, Sai-Hong Ou. Published in: Atlas Genet Cytogenet Oncol Haematol.

The serine/threonine kinase Akt, also known as protein kinase B (PKB), is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, includ …

BMS-777607是一种Met相关的抑制剂，作用于c-Met，Axl，Ron和Tyro3，在无细胞试验中IC50分别为3.9 nM，1.1 nM，1.8 nM和4.3 nM，作用于Met相关靶点比作用于Lck， VEGFR-2，和TrkA/B选择性高40倍，比作用于其他受体和非受体激酶选择性高500多倍。Phase 1/2。. ...

TransAM Elk-1 is a DNA-binding ELISA that quantifies the activated transcription factor using a method that is faster and more sensitive than gelshift, without radioactivity and gels.

Results: Of the 66 pts, 41 (62%) pts had wild-type (WT) KRAS and 25 (38%) pts harbored a KRAS mutation (codon 12 & 13). In the mutant KRAS group, 6 pts had SD (24%) and 19 pts had PD (76%) as their best OR; there were no responses. In the WT KRAS population, the PR rate was 12% (95% CI: 2 to 22), the SD rate was 54% (95% CI: 38 to 69), and the PD rate was 34% (95% CI: 20 to 49). The association between KRAS mutation status and lack of response to panitumumab was statistically significant (Fishers exact test, p = 0.003). From a Cox PH model, the hazard ratio for WT:mutant KRAS was 0.6 (95% CI: 0.34 to 0.95) for PFS and 0.5 (95% CI: 0.29 to 0.91) for OS. ...

Tumor protein 53 (p53) is a critical regulator of cell cycle and apoptosis that is frequently disabled in human tumors. In many tumor types, p53 is deleted or mutated, but in others p53 is inactivated by overexpression or amplification of its negative regulator mouse double minute 2 (MDM2). A high-t …

GtkWidget *dialog; dialog = gtk_recent_chooser_dialog_new (Recent Documents, parent_window, GTK_STOCK_CANCEL, GTK_RESPONSE_CANCEL, GTK_STOCK_OPEN, GTK_RESPONSE_ACCEPT, NULL); if (gtk_dialog_run (GTK_DIALOG (dialog)) == GTK_RESPONSE_ACCEPT) { GtkRecentInfo *info; info = gtk_recent_chooser_get_current_item (GTK_RECENT_CHOOSER (dialog)); open_file (gtk_recent_info_get_uri (info)); gtk_recent_info_unref (info); } gtk_widget_destroy (dialog ...

A meeting place of worldwide BIM managers and BIM professionals to gather information regarding BIM, BIM software, BIM classes, BIM conference, BIM...

pep:known chromosome:VEGA66:5:115631908:115647736:1 gene:OTTMUSG00000014704 transcript:OTTMUST00000034877 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Rab35 description:RAB35 member RAS oncogene family ...

The structure of MAS1 indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural…

A recent study from the Department of Cell Biology, University of Texas Southwestern Medical Center, Texas 75390, USA shows that XPO1 can be pharmacologically targeted in KRAS-mutant lung cancer. This study was... ...

The crisis at the BBC has been a long time coming and it will take far more than the resignation of George Entwistle to resolve it. That is because there is much more wrong at the BBC than just the problems highlighted by the Newsnight failings. Those failings have caused many people to wonder if…

Plasmid pDONR223-MERTK from Dr. William Hahns lab contains the insert MERTK and is published in Nature. 2010 Nov 24. ():. This plasmid is available through Addgene.

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In Extremis we find out a few unknown biological facts about the Doctor and Time Lords in general. We discover they have (or can...