Our approach described here provides a general avenue for observing single-liposome fusion events in proteoliposome systems (9, 12, 15, 34-36). Modification of the more conventional bulk-phase assays was kept minimal; one type of proteoliposome was attached to a nonsticky surface via specific interaction. Comprehensive controls and calibrations demonstrated that in vitro fusion activity in bulk solution is preserved in single-liposome fusion on surface. Real-time monitoring of SNARE-mediated, single-liposome fusion has revealed several key features: existence of hemifusion and additional intermediates on the pathway to full fusion and kinetic information on individual intermediate states. Furthermore, our assay might enable the dissection of the different fates of liposomes after fusion, for example, kiss-and-run type detachment. We should, however, emphasize that our work is based on yeast SNAREs and with a relatively high protein-to-lipid ratio (1:100) and therefore does not yet address the ...
As alternative splicing of the PLP gene yields four products - the classic PLP and DM20 proteolipids, and the more recently described proteolipids, srPLP and srDM20, it is important to try to understand how much of these various products are getting made by various kinds of cells in the nervous system, and their effects on those cells. A lot is already known, and more information is now acquired fairly continuously. Additionally, the (subcellular) localization of these products to various compartments within the cell is an important point (some get put into the myelin sheath, others get localized to the mitochondria, while other stay in the endoplasmic reticulum). The main question I think, at each instance, is whether there too much of this protein or not enough, and then also what is the effect of a poorly functioning, nonfunctioning or otherwise obstructive protein in each case? To this point, it is known that while transgenic mice that overexpress the PLP gene exhibit neuronal degeneration ...
AgrC is a membrane-embedded histidine kinase in Staphylococcus aureus that is thought to act as a sensor for the recognition of environmental signals and the transduction of signals into the cytoplasm so as to regulate and control a series of related pathogenic gene expression. However, for the complexity of cell membrane, it turns to be difficult to study AgrC on bacterial cell membrane directly. Many researches tried to take advantage of proteoliposome which could provide an approximate natural membrane environment and keep the protein activity to study the structure and function of membrane proteins. In order to build a transmembrane protein incorporation system with a relatively high incorporation efficiency, function activity and stability, various factors were considered, such as the impact of different charge polarity head on protein transmembrane incorporation efficiency. Here, four kinds of different charged liposomes were prepared by changing the phospholipid components in liposome and ...
The delivery of nucleotide sugar substrates into the endomembrane for processes such as cell wall biosynthesis and protein glycosylation is critical for plant growth and development. Although plant genomes encode large families of putative nucleotide sugar transporters (NSTs) that deliver the diverse array of nucleotide sugars found in plants, few have been characterized. Recently, we developed a yeast proteoliposome transporter assay coupled to LC-MS, specifically designed to characterize NSTs. ...
Proteoliposomes represent a suitable and up to date tool for studying membrane transporters which physiologically mediate absorption, excretion, trafficking and reabsorption of nutrients and metabolites. Using recently developed reconstitution strategies, transporters can be inserted in artificial bilayers with the same orientation as in the cell membranes and in the absence of other interfering molecular systems. These methodologies are very suitable for studying kinetic parameters and molecular mechanisms. After the first applications on mitochondrial transporters, in the last decade, proteoliposomes obtained with optimized methodologies have been used for studying plasma membrane transporters and defining their functional and kinetic properties and structure/function relationships. A lot of information has been obtained which has clarified and completed the knowledge on several transporters among which the OCTN sub-family members, transporters for neutral amino acid, B0AT1 and ASCT2, and others.
Structure and function of SemiSWEET.(a) Time course of [14C]-sucrose uptake by proteoliposomes containing EcSemiSWEET (solid black squares) or empty control lip
Looking for online definition of Pulmonary surfactant-associated protein a in the Medical Dictionary? Pulmonary surfactant-associated protein a explanation free. What is Pulmonary surfactant-associated protein a? Meaning of Pulmonary surfactant-associated protein a medical term. What does Pulmonary surfactant-associated protein a mean?
Surfactant protein C (SP-C), is one of the pulmonary surfactant proteins. In humans this is encoded by the SFTPC gene. It is a membrane protein which manufactures surfactant. The propeptide of pulmonary surfactant C has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide. It is associated with surfactant metabolism dysfunction type 2. Humans and animals born lacking SP-C tend to develop progressive interstitial lung disease. Keller A, Eistetter HR, Voss T, Schafer KP (Aug 1991). "The pulmonary surfactant protein C (SP-C) precursor is a type II transmembrane protein". Biochem J. 277 (Pt 2): 493-9. PMC 1151261 . PMID 1859376. Johansson H, Nordling K, Weaver TE, Johansson J (Jul 2006). "The Brichos domain-containing ...
Principal Investigator:UEDA Takashi, Project Period (FY):1997 - 1998, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Respiratory organ internal medicine
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Glucagon is a hormone that causes increase in blood glucose by promoting breakdown of liver glycogen. Glucagon is used for emergency treatment of severe hypoglycaemia. Administration of therapeutic glucagon as a rescue treatment for severe hypoglycaemia is safe and effective, however, its use is challenging due to its low solubility and very poor stability in liquid solution. Thus, currently available glucagon treatments (rescue kits) are only available in the form of a lyophilised powder, which requires the caregiver to perform a complex multi-step reconstitution procedure prior to administration in this highly stressful emergency situation. The reconstitution procedure leads to handling errors and delayed administration of glucagon, resulting in sub-optimal treatment. This is a significant barrier to the use of these rescue kits with recent usability studies demonstrating that more than 80% of people failed to reconstitute properly and inject the recommended dose of glucagon. As a result, only ...
Membrane proteins, especially passive ion channels, are very difficult to characterise using normal biophysical methods. This thesis used the transmembrane domain of the M2 proton channel of Influenza A (M2-TM) as a model system for biophysical investigations. Patch clamping is the most accurate method for assessing ion channel function, but requires rigid liposomes that can withstand mechanical stress, but are not usually optimal for structural investigations. Here a new hydrogen deuterium exchange (HDX) method has been optimised for the analysis of a membrane spanning peptides in lipid vesicles. A simple electrospray ionisation mass spectrometry method is introduced for HDX studies of carefully prepared aqueous proteoliposome samples. 11 backbone amide sites of M2-TM in lipid vesicles were shown to be resistant to HDX for several weeks. By contrast, HDX of M2-TM in methanol or in detergent micelles was complete within an hour, indicating that the peptide adopts a non-nativee conformation. A ...
Surfactant protein A1 (SP-A or SP-A1) is a member of the C-type lectin family of proteins, known as collectins. In humans, it is encoded by the SFTPA1 gene. SP-A is the major protein component of pulmonary surfactant, a lipoprotein complex secreted by the alveolar type II cell. Pulmonary surfactant reduces surface tension in the alveolus and prevents alveolar collapse during exhalation. In addition to its role as a surfactant, SP-A modulates the alveolar immune response to microbes and inhaled particulate matter. SP-A is also expressed in nonalveolar cells, and is thought to be involved in functions such as immune cell proliferation, stimulation of proinflammatory cytokine expression, and control of reactive oxygen species. Mutations in the SFTPA1 gene are associated with idiopathic pulmonary fibrosis. SP-A is also known as alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein, pulmonary surfactant-associated protein A1, surfactant protein A1B, collectin-4, SP-A1, PSAP, ...
Surfactant protein A1 (SP-A or SP-A1) is a member of the C-type lectin family of proteins, known as collectins. In humans, it is encoded by the SFTPA1 gene. SP-A is the major protein component of pulmonary surfactant, a lipoprotein complex secreted by the alveolar type II cell. Pulmonary surfactant reduces surface tension in the alveolus and prevents alveolar collapse during exhalation. In addition to its role as a surfactant, SP-A modulates the alveolar immune response to microbes and inhaled particulate matter. SP-A is also expressed in nonalveolar cells, and is thought to be involved in functions such as immune cell proliferation, stimulation of proinflammatory cytokine expression, and control of reactive oxygen species. Mutations in the SFTPA1 gene are associated with idiopathic pulmonary fibrosis. SP-A is also known as alveolar proteinosis protein, 35 kDa pulmonary surfactant-associated protein, pulmonary surfactant-associated protein A1, surfactant protein A1B, collectin-4, SP-A1, PSAP, ...
Effect of calcium on phospholipid interaction with pulmonary surfactant protein C.: Porcine pulmonary surfactant-associated protein SP-C was incorporated into b
Our droplet hydrogel bilayer system is an artificial bilayer system for interrogating membrane proteins, but it also allows us to explore new forms of synthetic biology where we can add individual protein function to a droplet, such as touch sensitivity or light sensitivity.. Using a novel DNA origami structure we can protect and controllably release our blocking DNA structures, known as DNA caltrops, to regulate the insertion of membrane proteins into these droplets. This allows us to trigger each functionality, on demand, using a small DNA ligand which removes the DNA caltrop from the proteoliposome.. We are looking for Honours or PhD students who have an interest in DNA origami design, synthetic biology, and artificial cells to learn across the interface of engineering and biology.. ...
Recent studies have been directed towards the potential therapeutic value of improving the sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA) function in the failing myocardium. Overexpression of SERCA pump or inhibiting the function of phospholamban (PLB) has been shown to improve the cardiac function in failing myocardium. Towards this goal, we enhanced the SERCA pump activity in both atria and ventricle by ablating its key regulators, PLB and sarcolipin (SLN). The homozygous double knockout (dKO) pups were delivered in Mendelian ratio and reached adulthood without any visible abnormalities. However, these mice develop cardiac hypertrophy. The heart weight to body weight ratio significantly increased in 3- 4 months old dKO mice (WT-3.08±0.11 vs. dKO-4.14±0.14) and is associated with enlargement of myocytes (WT-117±8 μm2 vs. dKO-166±10 μm2). Ablation of PLB and SLN did not affect the expression of major Ca2+ handling proteins including SERCA2a, calsequestrin, L-type Ca2+ channel and ...
Selol is an oily mixture of selenitetriacylglycerides that was obtained as a semi-synthetic compound containing selenite. Selol is effective against cancerous cells and less toxic to normal cells compared with inorganic forms of selenite. However, Selols hydrophobicity hinders its administration in vivo. Therefore, the present study aimed to produce a formulation of Selol nanocapsules (SPN) and to test its effectiveness against pulmonary adenocarcinoma cells (A549). Nanocapsules were produced through an interfacial nanoprecipitation method. The polymer shell was composed of poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA) copolymer. The obtained nanocapsules were monodisperse and stable. Both free Selol (S) and SPN reduced the viability of A549 cells, whereas S induced a greater reduction in non-tumor cell viability than SPN. The suppressor effect of SPN was primarily associated to the G2/M arrest of the cell cycle, as was corroborated by the down-regulations of the CCNB1 and CDC25C genes.
Previous studies have shown that a special proteolipid extract from the electric organ of Electrophorus showed high affinity binding for acetylcholine and other cholinergic agents. This proteolipid has now been incorporated into ultrathin lipidic membranes, and the membrane resistance was studied. The resistance decreased from 7.27 ± 0.82 x 105 ohm cm2 in the control membrane to 1.83 x 105 ohm cm2 with addition of 72 µg/ml proteolipid. The decrease in resistance followed a potential function of order four with the proteolipid concentration in the membrane-forming solution. The presence of this proteolipid determined some type of cationic selectivity which was not observed in the control. At a critical point of proteolipid concentration the conductance spontaneously fluctuated between two levels. The membrane current jumped from one state to another by way of single discrete steps, reminiscent of those obtained with the excitatory inducing material or the macrocyclic antibiotics. In membranes ...
Nanostructure Changes in Lung Surfactant Monolayers Induced by Interactions between Palmitoyloleoylphosphatidylglycerol and Surfactant Protein B Junqi Ding, Ivo Doudevski, Heidi E. Warriner, Timothy Alig, and Joseph A. Zasadzinski. What does a lung surfactant do?. Forms a monolayer Slideshow...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
The surfactant protein (SP-A) receptor SP-R210 has been shown to increase phagocytosis of SP-A-bound pathogens and to modulate cytokine secretion by immune cells. SP-R210S isoforms, splicing of small exons generates alternate forms of the unique carboxy-terminal domain name of Myo18A in macrophages [6]. Moreover, recent work offered in abstract form suggested that alternate splicing introduces […]. ...
Dr. Ledfords current work in the area of pulmonary surfactant immunobiology combines her knowledge of mouse genetics, pulmonary disease models and immune function regulation and focuses on understanding the role of Surfactant Protein-A (SP-A) and how it regulates signaling pathways within various immune cell populations. Specifically, she is interested in how SP-A regulates degranulation, either directly or indirectly, of two important cell types in asthma: mast cells and eosinophils. More recently, Dr. Ledfords research has focused on understanding how genetic variation within human SP-A2 alters functionality of the protein in relation to eosinophil activities and how this translates to characteristics observed in human asthma.. ...
Page contains details about calcein-loaded mechanosensitive channel of large conductance proteoliposomes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
SFTPC antibody [5E6A9] (surfactant protein C) for ELISA, WB. Anti-SFTPC mAb (GTX60670) is tested in Human samples. 100% Ab-Assurance.
The discovery of the porosome, its isolation, its structure and dynamics at nm resolution and in real time, its biochemical composition and functional reconstitution, are discussed.
Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. SFTPD is an innate immune system collectin. Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of influenza A virus. pulmonary surfactant GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116-26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081. Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795-802. PMC 1132609 . PMID 1339284. "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D". Brandt EB, Mingler ...
TY - JOUR. T1 - Glucocorticoid inhibition of human SP-A1 promoter activity in NCI-H441 cells. AU - Hoover, Russell R.. AU - Thomas, Klaus H.. AU - Floros, Joanna. PY - 1999/5/15. Y1 - 1999/5/15. N2 - Glucocorticoids have complex effects on human surfactant protein (SP) SP-A1 and SP-A2 gene expression that occur at both transcriptional and post-transcriptional levels. In the lung adenocarcinoma cell line NCI-H441, dexamethasone causes a dose-dependent decrease in total SP-A mRNA levels and inhibits SP-A gene transcription. In this study, a deletional analysis of the SP-A1 promoter was performed in order to identify cis-acting elements that mediate dexamethasone responsiveness in NCI-H441 cells. The region -32/+63 relative to the start of SP-A1 transcription mediated both basal promoter activity and dexamethasone repression of transcription. Removal of the region +18/+63 abolished dexamethasone responsiveness, indicating that sequences within this region are necessary for the inhibitory effect. ...
Mutations in the surfactant protein C gene (SFTPC) result in interstitial lung disease (ILD). Our objective was to characterize clinical and genetic spectrum of ILD in Chinese children associated with SFTPC mutations. Six Chinese children with ILD heterozygous for SFTPC mutations were included. Candidate genes responsible for surfactant dysfunction were sequenced by next-generation sequencing. Subclones of SFTPC with novel mutations were generated and transiently transfected into A549 cells. The functional characterization of mutant surfactant protein C (SP-C) was evaluated by Western blotting and immunofluorescence. The age of onset ranged from 7 days to 15 months. All cases required supplemental oxygen. Failure to thrive (5/6) was the most significant extra-pulmonary manifestation. Hydroxychloroquine was given as the long-term treatment of lung disease in four patients and two of them responded well. Three mutations were identified in six patients: four with I73T, one with D105G, one with Y113H.
PURPOSE: We evaluated allele frequencies and distribution of surfactant protein A2(SP-A2) in Korean neonates in order to estimate the prevalence of RDS, to find out new SP-A alleles, and to establish new steroid therapy. METHODS: Genomic DNA was extracted from 71 neonates and served as a template in PCR for genotype analysis. SP-A gene-specific amplications and gene-specific allele determinations were performed using PCR-cRFLP methods. RESULTS: The distribution for the alleles of the SP-A2 gene in the study population was 1A, 1A0, 1A1, 1A2, 1A3, 1A5, 1A6, 1A7, 1A8, 1A9, 1A11, 1A12. The specific frequencies for the alleles of the SP- A2 gene in the study population were : 1A=11.3%, 1A0=38%, 1A1=12.7%, 1A2=9.2%, 1A5=15.5%, 1A7= 2.9%, 1A8=4.9%, 1A9=2.2%, others=3.3%. CONCLUSION: The frequency of 1A0 was higher than the other SP-A2 alleles in Korean neonates. This finding suggests that the prevalence of RDS in Korea may be low compared with other countries. However, this finding also suggests that ...
MAL Full-Length MS Protein Standard (NP_002362), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or
Surfactant protein D小鼠单克隆抗体[10B2](ab26267)可与人样本反应并经WB, ELISA实验严格验证,被4篇文献引用。所有产品均提供质保服务,中国75%以上现货。
A process for the preparation of proteoliposomes comprising: (1) mixing a fusogen with lipid components used to form unilamellar lipid vesicles to thereby form fusogenic unilamellar lipid vesicles; an
Genetic variations of SP-C gene are known to cause interstitial lung disease. In previous studies 55 patients have been described focussing on the genetic abnormalities and clinical course.. Here we report the data of children with SP-C mutations collected between 1998 and 2010. Lung biopsy findings and previous radiological imaging studies were re-examined using up to date classifications.. All 11 children identified had heterozygous mutations in the SP-C gene, six of which carried I73T and five other mutations (H59R, G74V, C121F, E191X, A112T). Age at onset of symptoms ranged from birth to 11 years; however most presented with postnatal respiratory distress syndrome or later with tachypnea, cough and failure to thrive. Chest computer tomography showed a variety of different patterns including ground glass attenuation, mosaic pattern, lung fibrosis and cysts. Initial diagnosis was made by genetic testing alone in 6 of 11 cases and by lung biopsy in 5 patients. Histology pattern included non ...
H+-transporting two-sector ATPase, C subunit family protein; FUNCTIONS IN: ATPase activity; INVOLVED IN: ATP synthesis coupled proton transport; LOCATED IN: vacuole; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, F0/V0 complex, subunit C (InterPro:IPR002379), ATPase, V0 complex, proteolipid subunit C (InterPro:IPR000245); BEST Arabidopsis thaliana protein match is: vacuolar ATP synthase, putative / V-ATPase, putative (TAIR:AT4G32530.1); Has 1596 Blast hits to 1304 proteins in 284 species: Archae - 70; Bacteria - 89; Metazoa - 650; Fungi - 323; Plants - 223; Viruses - 0; Other Eukaryotes - 241 (source: NCBI BLink ...
We have studied a respiratory distress syndrome (RDS) occurring in newborn calves of the Belgian White and Blue (BWB) breed that represents the large majority of beef cattle in Belgium. Pulmonary surfactant isolated from 14 BWB newborn calves that died from RDS and from 7 healthy controls was analysed for composition and surface activity. An extremely low content or, in some instances, an absence of surfactant protein C (SP-C) was detected in the RDS samples by Western blotting and differential amino acid analysis [0.03±0.01% (w/w) relative to total phospholipids, compared with 0.39±0.06% for healthy controls (means±S.E.M., P , 0.001)]. The contents of surfactant protein B (SP-B) were similar in RDS and control samples. The crude surfactant samples isolated from RDS calves had higher ratios of total protein to total phospholipid, altered phospholipid profiles and lower SP-A contents. Both crude and organic extracts of RDS surfactant samples showed increased dynamic surface tension compared ...
Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases (ILDs). Furthermore, a mutation in the surfactant protein C gene that results in complete absence of the protein has been shown to be associated with familial ILD. The role of surfactant in lung disease is therefore drawing increasing attention following the elucidation of the genetic basis underlying its surface expression and the proof of surfactant abnormalities in ILD.
Adult hamsters were exposed to 100% oxygen for up to 8 days. At time of death lung tissue was analyzed for the expression of surfactant protein (SP) genes, and surfactant was isolated from alveolar lavage fluid. Surfactant was analyzed for the composition of proteins and phospholipids and for its surface properties. We found, over the 8 days of exposure, that an alveolitis composed of polymorphonuclear leukocytes (PMNs) and alveolar macrophages, accompanied by exudation of edema fluid, appeared in the alveolar spaces. The steady-state levels of SP mRNAs declined after 8 days of exposure to 100% oxygen, but the patterns indicated individual genetic control. SP-A was elevated early in the course of the hyperoxic exposure but decreased significantly by day 8; SP-B decreased continuously; SP-C was unchanged (or slightly elevated) through day 2 and then declined. The amounts of recoverable lavage surfactant increased by greater than threefold, and the phospholipid composition showed increasing percentages of
Rabbit polyclonal to TranscriptionfactorSp1. SLN-CTAb does not cross-react with any other low molecular protein in particular PLB. SLN could not be detected with total ventricular protein extract because of its very low level suggesting that microsomal fractions should be used to detect SLN in the ventricle. These results together suggest HA-1077 that we effectively produced a rabbit-polyclonal antibody particular for SLN which identifies SLN across varieties. Shape 1 (A) European blot evaluation of sarcolipin (SLN) and phospholamban (PLB) in the full total homogenate (Total), SR enriched microsomal fractions (SR) and post microsomal fractions (PM) from rat atria and ventricle. Bacterial draw out including rat and human being SLN … The manifestation design of SLN differs between little and bigger mammals To determine whether SLN proteins expression comes after its mRNA design HA-1077 [2-5], total proteins prepared from different muscle groups of mouse, rat, pet and rabbit were analyzed by ...
Biotin偶联Surfactant protein D抗体[IIE11](ab15695)可与大鼠, 人样本反应并经WB, IHC实验严格验证,被2篇文献引用,实验条件参看说明书。中国75%以上现货。
The long-term objective of this study is to determine how increased levels of native proteolipid protein (PLP) causes oligodendrocyte death, myelin degradation,...
Anti-mammaglobin antibodies, SCGB2A2 | Mammaglobin-A, human mammaglobin Q13296, mammaglobin antibody with no reactivity to no cross-reactivity to lipophilin A, lipophilin B (BU101), lipophilin C (lacryglobin, mammaglobin B), or uteroglobin mammaglobin,
Arclins resin-impregnated phenolic surface films stand up to the harshest outdoor environments. Uniform, durable and cost effective, these industrial overlays are versatile enough to meet most any market challenge.. Our 1000-series films are designed specifically for use on hardwood plywood panels for industrial and transportation applications. Or click here for more about our phenolic surface films for concrete forming.. ...
A mild, multi-phase cleansing composition is described that includes a cleansing phase including a structured surfactant component has a first density; a benefit phase includes an emulsion, the benefi
Documents : WHO/MAL/70.705, WHO/MAL/70.706 (WHO/VBC/70.179), WHO/MAL/70.707-70.708, WHO/MAL/70.709 (WHO/VBC/70.183), WHO/MAL/70.710-70.712, WHO/MAL/70.713 (WHO/VBC/70.189), WHO/MAL/70.714-70.715, WHO/MAL/70.716 (WHO/VBC/70.198), WHO/MAL/70.717-70.719, WHO/MAL/70.720 (WHO/VBC/70.197), WHO/MAL/70.721 (WHO/VBC/70.207), WHO/MAL/70.722-70.725, WHO/MAL/70.726 (WHO/VBC/70.222), WHO/MAL/70.727 (WHO/VBC/70.223), WHO/MAL/70.728-70.730, WHO/MAL/70.731 (WHO/VBC/70.247), WHO/MAL/70.732 (WHO/VBC/70.240), WHO/MAL/70.733 (WHO/VBC/70.230), WHO/MAL/70.734 (WHO/VBC/70.237), WHO/MAL/70.735 (WHO/VBC/70.248), WHO/MAL/70.736 (WHO/VBC/70.249), WHO/MAL/71.737, WHO/MAL/71.738 (WHO/VBC/71.251), WHO/MAL/71.739 (WHO/VBC/71.266), WHO/MAL/71.740, WHO/MAL/71.741 (WHO/VBC/71.278), WHO/MAL/71.742-71.747, WHO/MAL/71.748 (WHO/VBC/71.294), WHO/MAL/71.749, WHO/MAL/71.750 (WHO/VBC/71.304), WHO/MAL/71.751 (WHO/VBC/71.313), WHO/MAL/71.752-71.755, WHO/MAL/72.756-72.761, WHO/MAL/72.762 (WHO/VBC/72.337), WHO/MAL/72.763, WHO/MAL/72.764 ...
Surfactant, substance such as a detergent that, when added to a liquid, reduces its surface tension, thereby increasing its spreading and wetting properties. In the dyeing of textiles, surfactants help the dye penetrate the fabric evenly. Learn more about surfactants in this article.
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TY - JOUR. T1 - The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. AU - Haczku, Angela. AU - Atochina, Elena Nikolaevna. AU - Tomer, Yaniv. AU - Cao, Yang. AU - Campbell, Colleen. AU - Scanlon, Seth T.. AU - Russo, Scott J.. AU - Enhorning, Goran. AU - Beers, Michael F.. PY - 2002/10. Y1 - 2002/10. N2 - Pulmonary surfactant dysfunction may significantly contribute to small airway obstruction during the asthmatic response, but neither its exact role nor its regulation is clear. Surfactant function and composition was studied in an Aspergillus fumigatus (Af)-induced late-phase allergic airway response in sensitized BALB/c mice. The peak of Af-induced airway hyperresponsiveness in sensitized and challenged mice 24 h after allergen provocation coincided with a significant fall in surface activity of the pulmonary surfactant. The underlying changes included time-dependent elaboration of eotaxin and IL-5 followed by eosinophil influx into the ...