Background: Candida prosthetic joint infections are rare and its clinical characteristics and prognosis are still unclear. We retrospectively analyzed the clinical characteristics and prognosis of candida prosthetic joint infections.. Methods: 17 patients treated with candida prosthetic joint infections in 2 tertiary hospitals in South Korea between 2006 and 2013 were evaluated. 43 Patients with S.aureus prosthetic joint infections and 29 patients with S.epidermidis from the same hospitals were also evaluated. This was a retrospective cohort study, with a follow-up of at least 1year and 6months or until the patient died. Results: Candida and S.epidermidis prosthetic joint infections showed lower level of serum C-reactive protein(CRP)(mg/dL) compared to S.aureus prosthetic joint infections significantly.(median 3.0 vs 3.0 vs 6.0, p=0.029) White blood cell(WBC)(mm3)count from joint fluid of candida prosthetic joint infections was also lower than S.aureus prosthetic joint infections.(median 4045 vs ...
Prosthesis-related infection is a serious complication for patients after orthopedic joint replacement, which is currently difficult to treat with antibiotic therapy. Consequently, in most cases, removal of the infected prosthesis is the only solution to cure the infection. It is, therefore, important to understand the comprehensive interaction between the microbiological situation and the host immune responses that lead to prosthesis infections. Evidence indicates that prosthesis infections are actually biofilm-correlated infections that are highly resistant to antibiotic treatment and the host immune responses. The authors reviewed the related literature in the context of their clinical experience, and discussed the possible etiology and mechanism leading to the infections, especially problems related to bacterial biofilm, and prophylaxis and treatment of infection, including both microbiological and surgical measures. Recent progress in research into bacterial biofilm and possible future ...
TY - JOUR. T1 - Clinical effectiveness of treatment strategies for prosthetic joint infection following total ankle replacement. T2 - A systematic review and meta-analysis. AU - Kunutsor, Setor K. AU - Barrett, Matthew. AU - Whitehouse, Michael R. AU - Blom, Ashley W. PY - 2019/8/19. Y1 - 2019/8/19. N2 - Prosthetic joint infection (PJI) after total ankle replacement (TAR) is a challenging complication, which often requires debridement and implant retention (DAIR) with or without polyethylene exchange; revision surgery; implantation of a cement spacer; conversion to arthrodesis; or even amputation. The optimum treatment for ankle PJI is not well established. We conducted a systematic review and meta-analysis to compare the clinical effectiveness of various treatment strategies for infected ankle prostheses. We searched MEDLINE, Embase, Web of Science, and The Cochrane Library up to December 2018 for studies evaluating the impact of treatment in patient populations with infected ankle prostheses ...
The objective of this study is to present the results of cement spacer sonication in the second stage of two-stage treatment of shoulder arthroplasty infection and to determine the rate of positive cultures in the second-stage surgery in shoulder arthroplasty and its meaning. Twenty-one patients (22 cement spacers) treated with two-stage surgery because of a shoulder arthroplasty infection were included. In the second stage, the cement spacer was sent for sonication and at least four tissue cultures were obtained. Epidemiological data, comorbidities, sensitivity of the microorganisms to the antibiotic loaded in the cement spacer in the first revision surgery, time elapsed since an antibiotic was last administered until second revision procedure, functional shoulder status at last follow-up, and any complication were recorded. Three out of the 22 cases (13.6%) presented positive cultures at the second-stage surgery. Periprosthetic tissue culturing detected the three positive culture cases in the second
Several studies have identified characteristics associated with CIED infections. In a single-center case-control study,18 case subjects were more likely to have diabetes mellitus and heart failure and to have undergone generator replacement; renal dysfunction (glomerular filtration rate ,60 mL · min−1 · 1.72 m−2) had the strongest (odds ratio [OR] 4.8) association with CIED infection. Renal dysfunction was also associated with risk of CIED infection in a more recent nested case-control investigation.19 In addition, Lekkerkerker et al19 identified oral anticoagulant use as an associated risk factor for infection. In another single-center case-control study, 29 patients with PPM infection were included, and long-term corticosteroid use (OR=13.9) and the presence of more than 2 pacing leads (OR=5.41) were identified as independent correlates of device infection.20. In addition to patient factors, procedural characteristics may also play an important role in the development of CIED infection. ...
Summary Global Markets Directs latest Pharmaceutical and Healthcare disease pipeline guide Prosthetic joint infections - Pipeline Review, H2 2016, provides an overview of the Prosthetic joint infections (Musculoskeletal Disorders) pipeline landscape. Prosthetic joint infection (PJI) is one of the most serious complications of prosthetic joint implantation. Symptoms include pain or stiffness i
The current study provides an updated contemporary epidemiology of the microbiology of CIED infections requiring extraction. It is the largest report to date on this topic and used multiple sources for microorganism cultures including lead or lead material, blood, pocket tissue, and pocket swab cultures. There were multiple observations with direct implications for clinical practice and patient management.. This topic is becoming increasingly relevant in clinical practice due to an increase in the number of CIED implants but, most important, due to increase in CIED infections (2,3). In fact, the longevity of patients with cardiac disease has increased and the number of system revisions or upgrades that a patient would require in a lifetime will increase in parallel. The risk of a CIED infection, a time-dependent variable, would likely follow a similar trend and the rates of CIED infections have indeed shown a disproportionate trend to increasing CIED implants (2,3). CIED infections carry not ...
TY - JOUR. T1 - A two-stage retention débridement protocol for acute periprosthetic joint infections. AU - Estes, Chris S.. AU - Beauchamp, Chris P.. AU - Clarke, Henry D.. AU - Spangehl, Mark J.. PY - 2010/8. Y1 - 2010/8. N2 - Background: Due to the historically poor infection control rates with débridement and component retention for acute periprosthetic infections we developed a new approach for treating acute periprosthetic total joint infections: initial débridement with prosthesis retention and placement of antibiotic-impregnated cement beads followed by a second débridement within 7 days, at which time the beads are removed and new modular parts inserted. Intravenous antibiotics were used for 6 weeks followed by oral antibiotics. Depending on the clinical situation, antibiotics are discontinued or in selected patients continued indefinitely. Questions/purposes: We determined the ability of this two-stage débridement to control infection. Methods: We retrospectively reviewed the ...
160 patients who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution were recruited from August 2013 to August 2016. 80 patients meet the criteria of PJI from the muscle and skeletal muscle Association (MSIS) are divided to the infection group, another 80 patients are divided into the non-infection group.. Medical and demographic data were recorded. Collected lab examinations included blood routine test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial leukocyte counts, Receiver Operating Characteristic Curve-Area Under Curve (ROC-AUC) analysis will be used to evaluate the specific and sensitivity of diagnosis index. Moreover,microorganisms isolated from periprosthetic tissues and articular fluid. Postoperatively, the prosthesis was sent for ultrasound sonication. The sonicate extraction, implant surrounding tissue and synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also sent for ...
160 patients who underwent revision or re-revision total hip or knee arthroplasty for different reasons in our institution were recruited from August 2013 to August 2016. 80 patients meet the criteria of PJI from the muscle and skeletal muscle Association (MSIS) are divided to the infection group, another 80 patients are divided into the non-infection group.. Medical and demographic data were recorded. Collected lab examinations included blood routine test, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), synovial leukocyte counts, Receiver Operating Characteristic Curve-Area Under Curve (ROC-AUC) analysis will be used to evaluate the specific and sensitivity of diagnosis index. Moreover,microorganisms isolated from periprosthetic tissues and articular fluid. Postoperatively, the prosthesis was sent for ultrasound sonication. The sonicate extraction, implant surrounding tissue and synovium were sent for microbiologic culture, and the implant-surrounding-tissue were also sent for ...
RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening
For the diagnosis of prosthetic joint infection (PJI) automated BACTEC™ blood culture bottle methods have comparable sensitivity, specificity and a shorter time to positivity than traditional cooked meat enrichment broth methods. We evaluate the culture incubation period required to maximise sensitivity and specificity of microbiological diagnosis, and the ability of BACTEC™ to detect slow growing Propionibacteria spp. Multiple periprosthetic tissue samples taken by a standardised method from 332 patients undergoing prosthetic joint revision arthroplasty were cultured for 14 days, using a BD BACTEC™ instrumented blood culture system, in a prospective study from 1st January to 31st August 2012. The
The diagnosis of prosthetic joint infection (PJI) in the routine microbiology laboratory is labour-intensive, but semi-automated methods may be appropriate. We prospectively compared four microbiological culture methods on samples taken at prosthetic joint revision surgery. Automated BACTEC blood culture bottles and cooked meat enrichment broth were the most sensitive methods (87% and 83%, respectively, as compared with fastidious anaerobic broth (57%) and direct plates (39%)); all were highly specific (97-100%). To our knowledge, this is the first prospective study aimed at comparing culture methods in routine use in UK clinical laboratories for the diagnosis of PJI.
The management of periprosthetic joint infection following total joint arthroplasty is presently a major challenge to orthopedic surgeons. Despite various treatment options available, the two-stage revision procedure is most often chosen in North America because of a high success rate, especially in cases involving resistant organisms. Sometimes the use of antibiotics alone, irrigation with debridement, or a one-stage exchange may be a more appropriate treatment option. Various factors such as the status of a patients immune system, time of onset of the infection, as well as susceptibility of causative microorganism should be considered as they play an important role in effectiveness of treatment. When surgery presents a great risk to patients due to their level of health, and infection is caused by a low-virulent antimicrobial susceptible pathogen, antibiotic suppression alone may be the best treatment option. If the patient can successfully undergo surgery then an irrigation and
This book discusses Prosthetic Joint Infection (PJI), which remains one of the most common problems necessitating revision arthroplasty. It pursues a multidisciplinary approach, bringing together opin
China Orthopedic External Fixator supplier, Orthopedic Implant Plate Screw, Orthopedic Prosthesis Manufacturers/ Suppliers - Suzhou Ortho Instrument Co., Ltd.
The present invention provides a functionally graded glass/ceramic/glass sandwich system especially useful in damage resistant, ceramic dental and orthopedic prosthesis. The functionally graded glass/
The present invention provides a functionally graded glass/ceramic/glass sandwich system for use in damage resistant, ceramic and orthopedic prosthesis. The functionally graded glass/substrate/glass c
Prophylaxis is the term give to actions or treatments given to prevent disease. Pre-emptive medical care if you like.. New guidelines issued in 2012 by the American Association of Orthopedic Surgeons started that antibiotic prophylaxis is not now recommended for everyone with artificial joints or for those who already have orthopedic implants and who are about to undergo dental procedures. This has been endorsed by the ADA.. Your dentist will therefore take each patients requirements on a case by case basis. There are still valid grounds for prescribing antibiotic prophylaxis where patients have orthopedic implants. This is to prevent orthopedic implant infection. Example of appropriate scenarios include patients who have rheumatoid arthritis, diabetes, long term steroid users, cancer sufferers or those undergoing chemotherapy. All these reduce the effectiveness of the bodys immune system, which could lead to an increased risk of orthopedic implant infection.. Do, make your dentist aware if ...
Diagnosis of implant-related (periprosthetic joint) infections poses a major challenge to infection disease physicians and orthopaedic surgeons. Conventional diagnostic tests continue to suffer from issues of accuracy and feasibility. Biomarkers are used throughout medicine for diagnostic and prognostic purposes, as they are able to objectively determine the presence of a disease or a biological state. There is increasing evidence to support the measurement of specific biomarkers in serum and/or synovial fluid of patients with suspected periprosthetic joint infections. Promising serum biomarkers include interleukin (IL)-4, IL-6, tumour necrosis factor (TNF)-α, procalcitonin, soluble intercellular adhesion molecule 1 (sICAM-1), and D-dimer. In addition to c-reactive protein and leucocyte esterase, promising biomarkers that can be measured in synovial fluid include antimicrobial proteins such as human β-defensin (HBD)-2 and human β-defensin (HBD)-3, and cathelicidin LL-37, as well as several
Authors: Chi Xu, Yuhan Chang, Wadih Y. Matar, Daniel Varin, Jui Ping Chen RECOMMENDATION: Yes. Patients with liver disease such as hepatitis or cirrhosis have a higher risk of infection. These patients are at increased risk of intraoperative and postoperative bleeding. All efforts should be made to ensure such complications are minimized. LEVEL OF EVIDENCE:…
Husmann, Lars; Ledergerber, Bruno; Anagnostopoulos, Alexia; Stolzmann, Paul; Sah, Bert-Ram; Burger, Irene A; Pop, Roxana; Weber, Alberto; Mayer, Dieter; Rancic, Zoran; Hasse, Barbara; VASGRA Cohort Study (2018). The role of FDG PET/CT in therapy control of aortic graft infection. European Journal of Nuclear Medicine and Molecular Imaging, 45(11):1987-1997.. Scherrer, Alexandra U; Bloemberg, Guido; Zbinden, Reinhard; Zinkernagel, Annelies S; Fuchs, Claudio; Frauenfelder, Sandra; Rancic, Zoran; Mayer, Dieter; Hasse, Barbara (2016). Prosthetic vascular graft infections: bacterial cultures from negative-pressure-wound-therapy foams do not improve diagnostics. Journal of Clinical Microbiology, 54(8):2190-2193.. Alavi, Afsaneh; Sibbald, R Gary; Nabavizadeh, Reza; Valaei, Farnaz; Coutts, Pat; Mayer, Dieter (2015). Audible handheld Doppler ultrasound determines reliable and inexpensive exclusion of significant peripheral arterial disease. Vascular, 23(6):622-629.. Alavi, Afsaneh; Sibbald, R Gary; Mayer, ...
Eradication of prosthetic hip and knee joint infections is challenging, with failure rates |20% even in the setting of complete prosthesis removal.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Acute postoperative infection after total hip arthroplasty (THA) is typically treated with irrigation and débridement and exchange of the modular femoral head and acetabular liner. Given a rate of failure exceeding 50% in some series, a one-stage exchange has been suggested as a potential alternative because it allows more thorough débridement and removal of colonized implants. To date, most studies published on the one-stage exchange have used microbe-specific antibiotic-laden bone cement with only one small single-institution series that reported outcomes after a cementless one-stage exchange.. ...
Infections of the aorta remain one of the most dreaded complications in reconstructive vascular surgery. The purposes of this study were to evaluate the efficacy of a cryopreserved aortic allograft to treat an established vascular graft infection by the surgical in situ replacement of the infected segment in an animal model, and to investigate the role of antibiotics to decontaminate the allograft during the cryopreservation process. Furthermore, the tissue concentrations of the antibiotic and the kinetics of desorption were investigated in in vitro experiments. A model of prosthetic graft infection by Staphylococcus epidermidis RP-62 (inserted in the infrarenal aorta) in dogs was developed. By in situ replacement of the infected prosthetic graft with a cryopreserved aortic allograft, this study demonstrated an intrinsic resistance to infection of cryopreserved aortic allografts. However, antibiotic loading of the cryopreserved aortic allografts appeared to be essential to obtain optimal ...
NTM species are ubiquitous organisms found in the environment. The source of the bacterium was not identified in this case, but the two possible sources of infection are his prior corticosteroid injections or initial TKA surgery. The use of contaminated injections inoculation during the process of mixing the steroids, or upon the injection procedure have been reported sources of joint and cutaneous infections for NTMI.[1] Contamination during the procedure or early post-op soilage of surgical field, application of infected prosthesis, use of contaminated water, or shedding from transient NTM colonization can all be other causes of an NTMI.[2] In an investigation of an outbreak of NTM PJI in Oregon from 2010 - 2016, infections were even associated with the presence of a surgical instrument representative present in the operating room during the procedures.[3]. Review of the literature [4-9] yields a total of 7 additional cases of M. abscessus PJI of the knee (Table S1). The clinical presentations ...
OBQ11.195) A 50-year-old woman underwent cemented total knee arthroplasty 3 weeks ago. She reports that she has 1 week of drainage the size of a quarter on a gauze pad that she places over the incision three times daily. Her body mass index is 53 and her medical problems include hypertension and type 2 diabetes. Blood work shows a CRP of 1.1mg/L (normal 1-3mg/L). Knee aspiration yields WBC of 673 cells/mm(3) with 30% polymorphonucleocytes, and a negative gram stain. There is no surrounding erythema but there is a 1cm area at the inferior aspect of the wound that has a large amount of serous drainage able to be expressed. She has a painless range of motion is 0° to 117°. What would be the next most appropriate step in management? Review Topic , Tested Concept ...
A prosthetic joint such as a hip prosthesis includes a semipermeable membrane to encapsulate articulating surfaces of the joint. The semipermeable membrane permits circulation of natural body fluid to the articulating surfaces of the joint for lubrication purposes, while preventing systemic distribution of particulate generated at the articulating surfaces in the course of normal mechanical wear. In addition, the membrane isolates the articulating surfaces from other particulate debris, such as fragments of bone cement and/or bone ingrowth materials associated with the prosthesis-bone interface. One or more stay rings are carried by the membrane to prevent the membrane from becoming entrapped between articulatory surfaces of the prosthetic joint.
There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of severity. The aim of this study was to investigate the diagnostic and prognostic value of presepsin in PJI. A total of 30 patients with PJI and 30 patients without PJI were enrolled. Presepsin, C-reactive protein (CRP), serum interleukin (IL)-6, triggering receptor expressed on myeloid cells 1 (TREM-1), CCL2, matrix metalloproteinase 9 (MMP-9), CD163, osteopontin (OPN), and toll-like receptor 2 (TLR2) were measured at different times after surgery ...
This trial is investigating the efficacy of gentamicin impregnated sponge [Collatamp] in patients with peri-prosthetic joint infection after a joint replacement
Unusual implant-related soft tissue reaction presenting as a swollen leg: a case report. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
BACKGROUND:The aim of this study was to investigate the success rate of fungal peri-prosthetic joint infection treated by 2-stage revision and related factors of treatment failure to offer a better treatment protocol. MATERIAL AND METHODS:We reviewed...
The PRO-IMPLANT Foundation is committed to supporting research, education, global networking and care of patients with bone, joint or implant infection.
Background-Lead-related or valve-related endocarditis can complicate cardiovascular implantable electronic device (CIED) infection in patients with both CIED and prosthetic valves. The objective of this study was to determine the outcomes of transvenous lead extraction for CIED infection in patients
The diagnosis of periprosthetic joint infection (PJI) remains a challenge. However, recent studies showed that synovial fluid biomarkers have demonstrated greater diagnostic accuracy than the currently used PJI diagnostic tests. In many diagnostic tests, combining several biomarkers into panels is critical for improving diagnostic efficiency, enhancing the diagnostic precision for specific diseases, and reducing cost. In this study, we prove that combining alpha-defensin and C-reactive protein (CRP) as biomarkers possesses the potential to provide accurate PJI diagnosis. To further verify the result, we developed a multi-target lateral flow immunoassay strip (msLFIA) with staking pad design to obtain on-site rapid response for clinical diagnosis of PJI. A total of 10 synovial fluid samples were tested using the msLFIA, and the results showed that the combined measurements of synovial fluid alpha-defensin and CRP levels were consistent with those obtained from a commercial enzyme-linked immunosorbent
Staphylococci constitute a major part of our commensal flora but are also the most common bacteria causing prosthetic joint infections (PJIs), a dreaded complication of arthroplasty surgery. However, not all staphylococci are the same. The virulent Staphylococcus aureus has the ability to cause severe disease such as bacteremia and infective endocarditis in previously healthy people, while the coagulase-negative staphylococci Staphylococcus epidermidis and Staphylococcus capitis rarely act as pathogens unless the patient is immunocompromised or has an implanted medical device, such as a prosthetic joint. This thesis accordingly explores similarities and differences between these three staphylococci in PJIs.. S. capitis can cause early postinterventional and chronic PJIs, a finding that has not previously been described. Furthermore, its nosocomial NRCS-A outbreak sublineage, recently observed in neonatal intensive care units, is also present in adult PJIs. When comparing nasal and PJI isolates, ...
Two-stage revision arthroplasty is today considered as the gold standard for control of chronic deep prosthetic infection. Although the revision arthroplasty should only be considered when infection is eliminated, the diagnosis of residual infection prior to the revision remains a challenging problem. We evaluated triple-phase bone scintigraphy as a useful diagnostic test for the detection of residual infection around the antibiotic-impregnated cement spacer in patients waiting for the second-stage revision hip or knee arthroplasty. Increased uptake of radioisotope in all three phases was considered positive for infection. The final diagnosis was based on histopathological results in addition to microbiologic examinations of surgical specimens. Histopathological examination showed positive in 17 and negative in 13 out of 30 examinations. Among 17 samples positive for histopathology, there were only 4 samples positive for bacterial culture. All samples negative for histopathology showed negative for
1. Garvin KL, Hanssen AD. Current concepts review: Infection after total hip arthroplasty. J Bone Joint Surg Am. 1995;77:1576-1588 2. Fitzgerald Jr RH. Infected total hip arthroplasty: Diagnosis and treatment. J Am Acad Orthop Surg. 1995;3:249-262 3. Cui Q, Mihalko WM, Shields JS, Ries M, Saleh HJ. Antibiotic-impregnated cement spacers for the treatment of infection associated with total hip or knee arthroplasty. J Bone Joints Surg Am. 2007;89:871-882 4. Hanssen AD, Osmon DR. Evaluation of a staging system for infected hip arthroplasty. Clin Orthop Rel Res. 2002;403:16-22 5. Steinbrink K. The case of revision arthroplasty using antibiotic-loaded acrylic cement. Clin Orthop Rel Res. 1990;261:19-22 6. Steinbrink K, Frommelt L. Treatment of periprosthetic infection of the hip using one-stage exchange surgery. Orthopäde. 1995;24:335-343 7. Wroblewski BM. One-stage revision of infected cemented total hip arthroplasty. Clin Orthop Relat Res. 1986;211:103-107 8. Gollwitzer H, Diehl P, Gerdesmeyer L, ...
Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign material in many cases and also to the limited activity of antibiotics in infected bones. Clinical trials are difficult to design because of the heterogeneity of the disease and the number of factors that could influence the therapeutic response. To control for these multiple variables, attempts have been made to develop reliable animal models of osteomyelitis and prosthetic joint infections that closely mimic the different infections seen in orthopedic surgery and that allow evaluation of the efficacy of surgical procedures as well as local or systemic antibiotic therapy. These models will continue to provide us information on the pathogenesis and management of such infections.. ...
Staphylococcus epidermidis from prosthetic joint infections induces lower IL‐1β release from human neutrophils than isolates from normal flora Emeli Månsson, Bo Söderquist, Åsa Nilsdotter‐Augustinsson, Eva Särndahl, Isak Demirel APMIS. 2018 Aug;126(8):678-684. doi: 10.1111/apm.12861.
Abstract. Background: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk for infection. This study describes bone and joint infections (BJI) among HSCT recipients.. Methods: We reviewed 5861 patients who underwent HSCT at Mayo Clinic, Rochester, MN from January 1, 2005 through January 1, 2015 for study inclusion. BJI was defined as native septic arthritis, prosthetic joint infection, osteomyelitis, and orthopedic implant infection. All adults with BJI after HSCT were included in the analysis.. Results: Of 5861 patients, 33 (0.6%) developed BJI. Native joint septic arthritis was the most common BJI occurring in 15/33 (45.4%) patients. Patients were predominantly male (24/33, 72.7%), with median age of 58 (range 20-72) years. BJI was diagnosed a median of 39 (range 1-114) months after allogeneic (14/33, 42.4%) or autologous (19/33, 57.6%) HSCT. Organisms were recovered via tissue (24/27, 88.9%), synovial fluid (13/17, 76.5%), and/or blood cultures (16/25, 64%). Most ...
We thank the following individuals for their involvement and invaluable input throughout the development of this document: Robert Barrack MD, Keith Berend MD, Sandra Berrios-Torres (from Centers for Disease Control and Prevention), Kevin Bozic MD, John Esterhai MD, Ryan Fagan (from Centers for Disease Control and Prevention), Thomas Fehring MD, Terry Gioe MD, Teresa Horan (from Centers for Disease Control and Prevention), Steven Kurtz PhD, Bas Masri MD, Arvind Nana MD, Douglas Osmon MD, John Segreti MD, and Mark Spangehl MD. ...
appearance in the urine, with variable protein amounts and casts (red blood cells clumps), occurs.. Acute Nephritic Syndrome can be caused by a streptococcal infections including strep throat. In this case, the disorder is known as Poststreptococcal Glomerulonephritis. Acute Nephritic Syndrome can be also resulted from reactions to other infections, including malaria, prosthesis (infection of an artificial part of body), syphilis, hepatitis, chickenpox, abdominal organ abscess, pneumonia, and bacterial endocarditis.. About 50% of individuals with Acute Nephritic Syndrome experience no symptoms. When symptoms do exist, the first to happen are edema (retention with swelling of tissue), dark urine with blood, and low urine volume. Edema can first appear as puffiness of the eyelids and face, but later it occurs in legs; and edema can become severe. Brain swelling and high blood pressure can cause serious brain function disturbances, visual disturbances, and headaches.. The urine laboratory analysis ...
Harrington MD. Initial oral antibiotic therapy was noninferior to IV therapy for treatment failure in orthopedic infection at 1 y. Ann Intern Med. 2019;170:JC58. doi: 10.7326/ACPJ201905210-058. Download citation file:. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
With the trend toward pay-for-performance standards plus the increasing incidence and prevalence of periprosthetic joint infection (PJI), orthopaedic surgeons must reconsider all potential infection c
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, "Principles" of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, "Principles" of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
Dr. Garth Ehrlich, buy cialis expert researcher on chronic bacterial pathogenesis from Drexel University discusses that some of the most important research he is doing right now is establishing a link between periodontal bacteria and infections of the joints - whether they be peri-prosthetic joint infections, generic cialis which means if you have an artificial joint it gets infected - or whether you have somebody with osteoarthritis and the potential causative or exacerbative effect of periodontal pathogens.. Peri-prosthetic joint infections - are the most common reason a joint prosthesis needs to be removed, a very traumatic procedure. 100% of revision arthroplasties (joint prosthesis replacement) result from bacterial pathogens, and in the vast majority of cases there are bacteria present that had come from the mouth.. Osteoarthritis - the vast majority of people who have osteoarthritis have periodontal pathogens in their joints. Dr. Ehrlichs research is looking at whether these periodontal ...