TY - JOUR. T1 - A multicenter prospective cohort study to develop frailty-based prognostic criteria in heart failure patients (FLAGSHIP). T2 - Rationale and design. AU - on behalf of the FLAGSHIP collaborators. AU - Yamada, Sumio. AU - Adachi, Takuji. AU - Izawa, Hideo. AU - Izawa, Hideo. AU - Kondo, Takaaki. PY - 2018/8/2. Y1 - 2018/8/2. N2 - Background: Heart failure (HF) and frailty often co-exist, and frailty in HF results in a poor prognosis. However, in Asian populations, prognostic criteria are needed to examine the effect of frailty on HF. Therefore, we conducted a nationwide cohort study to develop frailty-based prognostic criteria in HF patients (FLAGSHIP). FLAGSHIP mainly aims to 1) develop the frailty criteria based on HF-specific outcomes, 2) propose a hypothesis of the potential mechanisms of frailty manifestations in HF, and 3) examine the effects of outpatient cardiac rehabilitation on frailty. Methods: In this prospective study, we consecutively enroll ambulatory patients ...
Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima
Pap screening, an effective method for cervical cancer prevention, is now supported by molecular human papillomavirus (HPV) testing. Recently commercialised preventive vaccines also provide new tools for the primary prevention of cervical cancer. To determine appropriate prevention strategies, the Health General Direction, Lombardy Region, funded a project that aims to characterize and monitor HPV infections and related cervical diseases in high-risk women.
Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Background and purpose: About 20% of patients with acute ischemic stroke experience symptom progression resulting in poor outcome. We have evaluated the effect of cilostazol compared with aspirin on preventing acute symptom progression, and on clinical outcome.. Methods: A multi-center, open, randomized, prospective comparative study conducted from April 2009 to March 2011. Inclusion criteria: non-cardioembolic ischemic stroke admitted within 48 hours of onset, neurologically stable, and with written informed consent. Exclusion criteria: contraindicated or previous exposure to aspirin and/or cilostazol. Patients were administered either cilostazol 200 mg daily (group C) or aspirin 200 mg daily (group A) within 48 hours of onset. Primary endpoint: occurrence of acute symptom progression (ΔNIHSS ≥2) within 7 days. Secondary endpoints: 3-month outcome (mRS 0-2), occurrence of vascular events (ischemic stroke, brain hemorrhage, myocardial infarction), bleeding events, and other adverse events. ...
Methods Prospective data on 204 lactating mothers of a healthy term singleton infant (normal pregnancy, labor and delivery) on day 2 after delivery. Exclusion: preterm and postterm infants, maternal treatment with antidepressant, anticonvulsants, or magnesium sulfate, previous breast surgery, opiates for analgesia; infants with major congenital malformations, or neonatal complications. Anthropometrics included: inter-nipple distance, nipple length, and horizontal and vertical diameters; cup size (best fit to a lactation bras); infant goniomaxillary length/gonio-mandibular length (GMxL/GMnL) ratio and intercommissural distance. A latch score was performed after measurements. Data collected included gravidity, parity, gestational age, previous breast feeding experience, and early breast feeding (,2 hours after delivery). Backward stepwise regression analysis was used to study the combined effect of several independent variables upon latch score. ...
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), ...
Multigenic approaches have been demonstrated to be valid tools for identifying subjects at risk for complex traits, such as type 2 diabetes (17) and coronary artery disease (18). A similar strategy was used in the present study, hypothesizing that, in subjects with type 2 diabetes, an increasing number of proinflammatory alleles may confer a significant risk of developing ischemic stroke. We have previously demonstrated the utility of the Go-DARTS cohort to study the contribution of gene variations to cardiovascular risk in subjects with diabetes (14-16). To our knowledge, this is the first prospective study that attempts to look at the impact of the combined effect of multiple gene variations on incident stroke. It is also the first prospective study considering the combination of multiple inflammatory SNPs in diabetic individuals.. The decision to study the rs1800795, rs5498, rs5361, rs1024611, and rs679620 of the IL-6, MCP-1, ICAM-1, sel-E, and MMP-3 genes was based on the following criteria. ...
Objective-To examine the relation between resting heart rate and new major ischaemic heart disease events in middle aged men with and without pre-existing ischaemic heart disease. Design-Prospective study of a cohort of men with eight years follow up for cardiovascular morbidity and mortality for all men. Setting-General practices in 24 British...
Tolerability of Shortened Infliximab Infusion in Scheduled Maintenance Therapy for IBD: a Prospective Multi-center European Cohort Study
To analyze the impact of multimorbidity (MM) on health care costs taking into account data heterogeneity. Data come from a multicenter prospective cohort study of 1,050 randomly selected primary care patients aged 65 to 85 years suffering from MM in Germany. MM was defined as co-occurrence of ≥3 conditions from a list of 29 chronic diseases. A conditional inference tree (CTREE) algorithm was used to detect the underlying structure and most influential variables on costs of inpatient care, outpatient care, medications as well as formal and informal nursing care. Irrespective of the number and combination of co-morbidities, a limited number of factors influential on costs were detected. Parkinsons disease (PD) and cardiac insufficiency (CI) were the most influential variables for total costs. Compared to patients not suffering from any of the two conditions, PD increases predicted mean total costs 3.5-fold to approximately € 11,000 per 6 months, and CI two-fold to approximately € 6,100. The high
To analyze the impact of multimorbidity (MM) on health care costs taking into account data heterogeneity. Data come from a multicenter prospective cohort study of 1,050 randomly selected primary care patients aged 65 to 85 years suffering from MM in Germany. MM was defined as co-occurrence of ≥3 conditions from a list of 29 chronic diseases. A conditional inference tree (CTREE) algorithm was used to detect the underlying structure and most influential variables on costs of inpatient care, outpatient care, medications as well as formal and informal nursing care. Irrespective of the number and combination of co-morbidities, a limited number of factors influential on costs were detected. Parkinsons disease (PD) and cardiac insufficiency (CI) were the most influential variables for total costs. Compared to patients not suffering from any of the two conditions, PD increases predicted mean total costs 3.5-fold to approximately € 11,000 per 6 months, and CI two-fold to approximately € 6,100. The high
Supplementary MaterialsSupplementary materials 1 (DOCX 637 KB) 392_2019_1424_MOESM1_ESM. not analyzed. The medial and lateral plots and by the KolmogorovCSmirnov test. Normally and non-Gaussian distributed variables were reported as mean (SD) or median (interquartile range), respectively. All biomarker levels were log10 transformed and normalised to 1 1 SD increment. Normalised data were analysed using ANOVA and general linear models, and values were Bonferroni-corrected for multiple comparisons. Non-Gaussian data and categorical variables were analysed using non-parametric tests [MannCWhitney test, KruskalCWallis test and Spearman (value(%) and imply (SD) or median (Interquartile range) are reported. beliefs are quoted for the ANOVA/Kruskal Chi or Wallis squared exams for constant or categorical factors, respectively angiotensin 2 receptor blocker Relationship evaluation PENK was correlated to age group (rating of log natriuretic peptides (0.437, nonsignificant). Open up in another home window ...
In the frame of multicenter research studies, biobanks ensure the harmonization and traceability of the prospective collection of quality samples. This is significant because pre-analytical variables must be carefully considered to guarantee the integrity of biomarkers to be tested and to avoid bias affecting the validity of the analytical results. According to a quality management system, biobanks contribute with documents and records; consumable preparation for collection, processing, and conservation; sample quality controls; and centralized management of sample handling, storage, and distribution. Traceability of samples is based on unique standard codes and the use of pre-assigned, pre-coded, and pre-labeled materials for sample collection, processing, and conservation. By using these supporting tools, quality derivatives are obtained based on common and evidence-based standard operating procedures (SOPs), with associated traceability information in relation with their collection, processing,
Langdorf MI, Medak AJ, Hendey GW, Nishijima DK, Mower WR, Raja AS, Baumann BM, Anglin DR, Anderson CL, Lotfipour S, Reed KE, Zuabi N, Khan NA, Bithell CA, Rowther AA, Villar J, Rodriguez RM. Prevalence and Clinical Import of Thoracic Injury Identified by Chest Computed Tomography but Not Chest Radiography in Blunt Trauma: Multicenter Prospective Cohort Study. Ann Emerg Med. 2015 Dec;66(6):589-600. doi: 10.1016/j.annemergmed.2015.06.003. Epub 2015 Jul 11. PubMed PMID: 26169926 ...
OBJECTIVE--To examine the associations between air temperature and risk factors for ischaemic heart disease. METHOD--Data on risk factors are available from up to 2036 men in the Caerphilly Prospective Heart Disease Study. Daily temperatures were obtained from the Meteorological Office. Relations between these were examined by regression. RESULTS--The coldest month of the year has a mean temperature that is 16 degrees C lower than that in the warmest month. A fall in temperature of this magnitude is associated with higher blood pressures (by 3-5 mm Hg) and a lower concentration of high density lipoprotein cholesterol (by 0.08 mmol/l). The most important effects however, seem to be on the haemostatic system. Fibrinogen is 0.34 g/l higher in the coldest month than in the warmest (p , 0.001) and alpha 2 macroglobulin, a protein that inhibits fibrinolysis, is also raised. Platelet count is increased by 30% of a standard deviation and the sensitivity of platelets in whole blood to adenosine ...
To determine the time course of development of resistance to atevirdine mesylate ( U-87201E ) in patients with HIV isolates showing in vitro resistance to zidovudine ( AZT ). To determine the genotype changes in HIV reverse transcriptase associated with in vitro AZT resistance to U-87201E. To determine the genotype and phenotype effects of treatment with a nondideoxynucleoside agent on the alterations of the HIV-1 population associated with in vitro AZT resistance. To determine whether serial passage of patient pre-drug HIV isolates in the presence of U-87201E will generate the resistant mutants that may subsequently emerge in the patients ...
This page contains the abstract Morbidity and Mortality of Major Adult Spinal Surgery. A Prospective Cohort Analysis of 942 Consecutive Patients http://www.chiro.org/LINKS/ABSTRACTS/Morbidity_and_Mortality_of_Major_Adult.shtml
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism Journal Articles Refereed ...
This study is the first to document the population incidence in the UK of SUPC in infants who were assessed as being healthy at birth. The incidence (0.05/1000 term live births) is consistent with case, regional and national series, suggesting an incidence ranging from between 0.026/1000 live births in the first 24 h of birth10 to 0.27/1000 where collapse occurs within 3 days of birth.2 The overall BPSU respondent rate (94.6% for 2008) is higher than any equivalent UK scheme and ranks highly against other national paediatric surveillance units. However, complete ascertainment of all cases of SUPC occurring within the study period could not be verified. This was due to the complexity of the case definition and the heterogeneity that exists in the classification of such infant deaths, which precluded cross-checking against national and regional databases. As such, the incidence in this study may be an underestimate.. One third of infants had an underlying condition leading to collapse and a ...
Background Multiple Sclerosis (MS) is the most common cause of neurological disability in young and middle-aged adults. At this stage in life most people are in the midst of their working career. The...
Context: Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. Objective: To characterize the natural course of depressive symptoms among older women (from the young old to the oldest old) followed up for almost 20 years. Design: Using latent-class growth-curve analysis, we analyzed women enrolled in an ongoing prospective cohort study (1988 through 2009). Setting: Clinic sites in Baltimore, Maryland; Minneapolis, Minnesota; the Monongahela Valley near Pittsburgh, Pennsylvania; and Portland, Oregon. Participants: We studied 7240 community-dwelling women 65 years or older. Main Outcome Measure: The Geriatric Depression Scale short form (score range, 0-15) was used to routinely assess depressive symptoms during the follow-up period. Results: Among older women, we identified 4 latent classes during 20 years, with the predicted probabilities of group membership totaling 27.8% with ...
This study represents the largest prospective series of febrile children returning from the tropics. We have identified a high proportion of treatable conditions, and highlighted the importance of common cosmopolitan infections as well as exotic illnesses presenting with fever in this population. The majority of diagnoses requiring medical treatment were made using simple investigations.. Previous studies of imported infections have concentrated on adult travellers presenting to tertiary centres,6 often returning from Sub-Saharan Africa.4,5 Our study population, being largely South Asian, is therefore very different. Most imported malaria from the Indian subcontinent is caused by Plasmodium vivax, as in our study.9 Only 30% of children with this type of malaria present within a month of return.9 Imported malaria from Africa is mostly P falciparum, a potentially life threatening infection. This mostly presents within one month of return.9. Many new arrivals from Africa will stay in the South East ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The majority of youth with type 1 diabetes are above hemoglobin A1c (HbA1c) targets. Continuous glucose monitoring (CGM) has been shown to improve clinical outcomes, and use early in the course of diabetes has the potential to improve glycemic outcomes and improve quality of life.. In our clinic, youth with new-onset type 1 diabetes were offered the opportunity to start on CGM (Dexcom G6) soon after diabetes diagnosis. Ongoing CGM coverage was subsequently applied for through the patients insurance. Following CGM initiation, youth had a 1-week follow-up with a nurse practitioner. Per clinic standard of care, youth were seen again at 1 month post-diagnosis and every 3 months thereafter. We prospectively collected data on HbA1c, continued CGM use, days of CGM wear, method of viewing CGM data, time in range (TIR), and time in hypoglycemia. Institutional review board approval was obtained for the prospective data collection.. From July 2018 to April 2019, we approached 44 youth with newly diagnosed ...
Data presented as median (interquartile range). P value by Kruskall-Wallis. Intergroup differences by Mann Whitney. +P value significantly higher in fentanyl group compared to morphine group (p,0.05). N.S=Non Significant ...
Following this initial letter, two subsequent case series have been published supporting the peripheral-IJ as a reasonable alternative for temporary venous access. The first case series of 9 patients placed them in patients with unobtainable IV access [2]. 64 mm angiocatheters were used to cannulate the IJ under ultrasound guidance using the above-described technique. All catheters were labeled for removal within 72 hrs. All patients were followed up via chart review one year later. Two of 9 catheters failed due to kinking within the first 48 hrs. There were no apparent adverse outcomes in any patient including deep vein thrombosis, bacteremia, endocarditis or pneumothorax. A second group conducted a prospective case series in which 9 patients underwent placement of a peripheral IJ" (PIJ), when other access could not be obtained and the patient did not initially require a central line [3]. The authors attempted follow-up with all patients within a week. On follow-up, the seven patients who ...
Use the SQL Server aggregate function IQR to calculate inter-quartile range. Documentation on over 260 SQL Server statistical functions including examples that can be copied directly into SSMS.
To characterize the PK of IgG following intravenous IgPro10 dosing in Japanese PID subjects after a standard wash-in/wash-out period of 12 weeks.
The results of current meta-analysis study support the use of GCE supplementation for the improvement of obesity indices, with sub-group analysis highlighting greater improvements in individuals with a starting BMI ≥25 kg/m|sup|2|/sup|.
It was the objective of this study to document and evaluate AZT-induced short-term toxicity in healthy individuals. The study was designed as a longitudinal monocentric side-effect monitoring study with prospective data collection. It was carried out at the Cologne University Hospital. The study population comprised health care workers who were...
The concept of exclusive breastfeeding in relation to daily feeding practices and to health and growth of infants in an affluent society was examined. In a descriptive longitudinal prospective study 506 mother-infant pairs were followed from birth through the greater part of the first year. Feeding was recorded daily, and health and growth were recorded fortnightly. Large individual variations were seen in breastfeeding patterns. A wide discrepancy between the exclusive breastfeeding rates obtained from "current status" data and data "since birth" was found.. Using a strict definition of exclusive breastfeeding from birth and taking into account the reasons for giving complementary feeding, the study showed that many exclusively breastfed infants had infections early in life, the incidence of which increased with age, despite continuation of exclusive breastfeeding. However, truly exclusively breastfed infants seem less likely to suffer infections than infants who receive formula in addition to ...
This article explains a prospective study at an academic hospital studying adverse events in 400 consecutive patients after discharge from a medical service. The authors describe the incidence, severity, and preventability of reported events along with specific examples captured during the study. They discuss strategies to improve patient safety by emphasizing the vulnerability of the discharge transition from hospital to home.
Population-based disease registry systems are invaluable research resources due to their non-biased coverage, prospective data collection, large size, and length of follow up.
SI-BONE, Inc. Announces Publication of 3-Year Long-term Prospective Outcomes Including Randomized Controlled Trial Data on 103 Patients Post SI Joint Fusion
Fingerprint Dive into the research topics of Prospective assessment of patient morbidity from prone sacral positioning: Clinical article. Together they form a unique fingerprint. ...
Université de Liège - ULiège , Département des sciences de la santé publique , Santé publique, Epidémiologie et Economie de la santé ,] ...
The main purpose of the study is to determine the onset of Mavenclad® action by frequent magnetic resonance imaging (MRI) assessment of the combined unique
Results: Cross-sectional associations between optimism and each of the study outcomes were strongly protective but tended to differ according to gender in extent. In prospective analyses of the onset of new cases of each study outcome, protective associations were weaker. Those in the highest optimism quartile had risks for depressive symptoms that were reduced by almost half (odds ratio: 0.54 [95% confidence interval: 0.42-0.70]) compared with those in the lowest category. No effect was seen in prevention of anxiety symptoms after adjustment for other aspects of psychological style. In predicting the onset of heavy substance use and antisocial behavior, high optimism had modest protective effects. ...
Data centres have become a critical piece of technological infrastructure in todays information age. Any business or organization that manages a large volume of information can benefit from operating a well-structured data centre. Data centres are facilities in which networked computers, storage, and hardware work together to manage large sums of data. Data centres have ...
Question: I am on the down side of my 50s and have been struggling not only to push myself to exercise but once I get there my joints hurt for the first half
The president-elect and his wife have arrived in Washington, D.C. ahead of Fridays Inauguration. The Trumps touched down Thursday afternoon at Andrews Airforce Base inside a military jet. Now, the soon-to-be first daughter Ivanka Trump is speaking out ov
In 2012 the law changed. Deposits taken by residential landlords must now be handed over to one of three government-approved Tenancy Deposit Schemes within 30 days of the start of the tenancy.
Security for Future Networks : a Prospective Study of AAIs Hassane Aissaoui, Pascal Urien, Guy Pujolle, Fraga Joni da Silva, Böger Davi da Silva To cite this version: Hassane Aissaoui, Pascal Urien, Guy
Kling and his family arrived at the hospital at 7:30 a.m. He was then prepped and waiting in the pre-operating room as surgeon Dr. Jim Maloney examined the lung for any possible complications. Once he deemed it safe to proceed, the rest moved quickly.. Steve Kling looks out over his farm after returning to his home on January 13. Unable to complete barn chores on his own, he is hopeful he will find a young couple to help transition ownership of the herd.. "It was just like a scene from the movies," Kling said. "The surgeon came out and said, Its a go. It was time for hugs and kisses and they were taking me back.". The surgery went smoothly and by 7:30 p.m., Kling was awake. He said it was nothing short of amazing.. "It really felt like a dream. During the surgery, I was on a breathing machine. Once they took out the tube, I was breathing on my own. I didnt need oxygen anymore," Kling said.. Kling spent nine days in the hospital and another eight in a hotel nearby. During this time, Kling was ...
French comment on article Endoscopic gastric reduction with an endoluminal suturing device: a multicenter prospective trial with 1-year follow-up ...
Two techniques have been utilized to make sure higher precision of the results. The data have been 1st manually transferred to standardized forms, then double
Visit the French Mediterranean and enjoy a tranquil day looking out over the sea at some of the clearest and most vivid skies you will find anywhere in the world.
Hi - I am pulling my hair out over here trying to find a script that will rotate a set of quotes for me... can anyone help me or give me one? I am *not* looking for one that will change every time the page is loaded... I am looking for one that will show a quote for a few seconds and then show the next one for a few seconds, etc etc.... Thanks in advance for any help!!
Aspirus Wausau Hospital today announced the first extensive multi-O.R. integration project in the US with Buzz™ Digital O.R. at Aspirus Wausau Hospital.
Aspirus Wausau Hospital today announced the first extensive multi-O.R. integration project in the US with Buzz™ Digital O.R. at Aspirus Wausau Hospital.
prospective risks of binary options trading her - risks of binary options trading, binary options brokers low minimum deposit, binary options robot отзывы, canadian binary option broker
OBJECTIVES--To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN--Prospective study of a cohort of men followed up for 9.5 years. SETTING--General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS--Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general practice in each of 24 towns, were studied. MAIN OUTCOME MEASURES--Fatal and nonfatal ischaemic heart disease events. RESULTS--Risk of major ischaemic heart disease events was significantly increased at haematocrit levels of , or = 46.0%. Men with raised haematocrit (, or = 46.0%) showed a 30% increase in relative risk (RR) of major ischaemic heart disease events (RR = 1.32; 95% confidence intervals (CI) 1.10,1.57, p , 0.01) compared with those with values below 46.0%, even after adjustment for age, social class, smoking, body mass index, physical activity, blood cholesterol, lung function (FEV1), and ...
Fertility and pregnancy issues are of key importance for young breast cancer patients. Despite several advances in the field, there are still multiple unmet needs and barriers in discussing and dealing with these concerns. To address the significant challenges related to fertility and pregnancy issues, the PREgnancy and FERtility (PREFER) study was developed as a national comprehensive program aiming to optimize care and improve knowledge around these topics. The PREFER study is a prospective cohort study conducted across several Italian institution affiliated with the Gruppo Italiano Mammella (GIM) group evaluating patterns of care and clinical outcomes of young breast cancer patients dealing with fertility and pregnancy issues. It is composed of two distinctive studies: PREFER-FERTILITY and PREFER-PREGNANCY. The PREFER-FERTILITY study is enrolling premenopausal patients aged 18-45 years, diagnosed with non-metastatic breast cancer, who are candidates to (neo)adjuvant chemotherapy and not previously
Grieving relatives can suffer from numerous consequences like anxiety, depression, post-traumatic stress disorder (PTSD) symptoms, and prolonged grief. This study aims to assess the psychological consequences of grieving relatives after patients death in French palliative care units and their needs for support. This is a prospective observational multicenter mixed study. Relatives of adult patients with a neoplasia expected to be hospitalized more than 72 h in a palliative care unit for end-of-life issues will be included within 48 h after patient admission. End-of-life issues are defined by the physician at patient admission. Relatives who are not able to have a phone call at 6-months are excluded. The primary outcome is the incidence of prolonged grief reaction defined by an ICG (Inventory Complicate Grief) | 25 (0 best-76 worst) at 6 months after patient death. Prespecified secondary outcomes are the risk factors of prolonged grief, anxiety and depression symptoms between day 3 and day 5 and at 6
Objective: To report adverse events (AEs) seen in a large cohort of patients with Juvenile Idiopathic Arthritis (JIA) treated with TNFα blockers (Infliximab and Etanercept).. Methods: All JIA patients treated with Infliximab or Etanercepet at the Paediatric Rheumatologic Centre of the G. Pini Institute (Milan) from November 1999 to February 2006, were enrolled in an open, monocenter, long-term prospective study.. Results: 163 patients (68 Infliximab, 95 Etanercept) were enrolled. Mean onset age 6.4±4.8 years, mean age 17.19.2 years, mean therapy duration 22.9±17.6 months. 45 patients (32 Infliximab, 13 Etanercept) failed to respond to or did not tolerate the first biologic and switched to a second one. 208 treatments (81 Infliximab, 127 Etanercept) were done. 71 AEs occurred in 51 (62.9%) Infliximab patients and led to discontinuation in 26 (32.1%). 133 AEs occurred in 69 (54.3%) Etanercept patients and led to discontinuation in 18 (14.2%). Some AEs, such as thrombocytopenia, ...
TY - JOUR. T1 - A dose-response meta-analysis of the impact of body mass index on stroke and all-cause mortality in stroke patients. T2 - a paradox within a paradox. AU - Bagheri, M.. AU - Speakman, J. R.. AU - Shabbidar, S.. AU - Kazemi, F.. AU - Djafarian, K.. N1 - Acknowledgements We thank Dr. Nicola Orsini for helping us with the statistical analysis. This study was supported by Tehran University of Medical Sciences.. PY - 2015/5. Y1 - 2015/5. N2 - The obesity paradox is often attributed to fat acting as a buffer to protect individuals in fragile metabolic states. If this was the case, one would predict that the reverse epidemiology would be apparent across all causes of mortality including that of the particular disease state. We performed a dose-response meta-analysis to assess the impact of body mass index (BMI) on all-cause and stroke-specific mortality among stroke patients. Data from relevant studies were identified by systematically searching PubMed, OVID and Scopus databases and were ...
TY - JOUR. T1 - Re. T2 - the natural history of penile length after radical prostatectomy: a long-term prospective study.. AU - Morey, Allen F.. PY - 2013/8. Y1 - 2013/8. UR - http://www.scopus.com/inward/record.url?scp=84887337808&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84887337808&partnerID=8YFLogxK. M3 - Article. C2 - 23845350. AN - SCOPUS:84887337808. VL - 190. SP - 592. JO - Journal of Urology. JF - Journal of Urology. SN - 0022-5347. IS - 2. ER - ...
Jehan, I., Harris, H., Salat, S., Zeb, A., Mobeen, N., Pasha, O., ... Goldenberg, R. L. (2009). Neonatal mortality, risk factors and causes: A prospective population-based cohort study in urban Pakistan. Bulletin of the World Health Organization, 87(2), 130-138. DOI: 10.2471/BLT.08.050963 ...
OBJECTIVES: If proven acceptable, safe and effective, the diaphragm could be used as a female-controlled method of preventing both sexually-transmitted infections (STIs) and pregnancy. This studys aim was to assess the acceptability and safety of the diaphragm among sexually-active women in Mombasa, Kenya. METHODS: We conducted a 6-month prospective study among female sex workers (FSWs), and women attending sexual and reproductive health services. Diaphragm acceptability was assessed using continuation rates and factors associated with acceptability. Safety evaluations included colposcopy findings and incidence of urinary tract infections (UTIs) and STIs. RESULTS: Half the 185 participants were FSWs who had less schooling and were less likely to be married than other women. After 6 months, 55% (56/102) of sexually-active women reported having used the diaphragm each sex act during the preceding month. Women liked using the diaphragm (95%, 104/109), and 96% (125/130) reported willingness to ...
BÜHLMANN fCAL® ELISA Citation: Beswick, L. et al. Exploration of predictive biomarkers of early infliximab response in acute severe colitis: A prospective pilot study. Journal of Crohns and Colitis. 2017 Nov 7. DOI: 10.1093/ecco-jcc/jjx146. PMID: 29121178 . Highlight from this Publication
Clinical trial for Mother to Child Transmission of HIV , Prospective Observational Cohort Study on Mother to Child Transmission HIV1/HIV2 and Prevention
Atrial fibrillation (AF) after thoracic surgery is a continuing source of morbidity and mortality. The effect of postoperative AF on long-term survival however has not been studied. Our aim was to evaluate the impact of AF on early outcome and on survival | 5 years after pulmonary lobectomy for lung cancer. From 1996 to June 2009, 454 consecutive patients undergoing lobectomy for lung cancer were enrolled and followed-up until death or study end (October 2010). Patients with postoperative AF were identified; AF was investigated with reference to its predictors and to short- and long-term survival (| 5 years). Hospital mortality accounted for 7 patients (1.5%), while postoperative AF occurred in 45 (9.9%). Independent AF predictors were: preoperative paroxysmal AF (odds ratio [OR] 5.91; 95%CI 2.07 to 16.88), postoperative blood transfusion (OR 3.61; 95%CI 1.67 to 7.82) and postoperative fibro-bronchoscopy (OR 3.39; 95%CI 1.48 to 7.79). Patients with AF experienced higher hospital mortality (6.7% vs. 1.0%
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
IMPORTANCE: Muscle pain, fatigue, and weakness are common adverse effects of statin medications and may decrease physical activity in older men. OBJECTIVE: Determine whether statin use is associated with physical activity, longitudinally and cross-sectionally. DESIGN, SETTING, AND PARTICIPANTS: Men participating in the Osteoporotic Fractures in Men Study, a multicenter prospective cohort study of community-living men age 65+, enrolled between March 2000-April 2002. EXPOSURE: Statin use as determined by an inventory of medications (taken within last 30 days). In cross-sectional analyses, statin use categories were: users and nonusers. In longitudinal analyses, categories were: prevalent users (baseline use and throughout study), new users (initiated use during the study) and nonusers (never used). MAIN OUTCOMES AND MEASURE: Self-reported physical activity at baseline and 2 follow-up visits using the Physical Activity Scale for the Elderly (PASE). At the third visit, an accelerometer measured ...
TY - JOUR. T1 - Association between dietary whole grain intake and risk of mortality. T2 - Two large prospective studies in US Men and Women. AU - Wu, Hongyu. AU - Flint, Alan J.. AU - Qi, Qibin. AU - Van Dam, Rob M.. AU - Sampson, Laura A.. AU - Rimm, Eric B.. AU - Holmes, Michelle D.. AU - Willett, Walter C.. AU - Hu, Frank B.. AU - Sun, Qi. PY - 2015/3/1. Y1 - 2015/3/1. N2 - IMPORTANCE: Higher intake of whole grains has been associated with a lower risk of major chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease (CVD), although limited prospective evidence exists regarding whole grains association with mortality. OBJECTIVE: To examine the association between dietary whole grain consumption and risk of mortality. DESIGN, SETTING, AND PARTICIPANTS: We investigated74 341 women from the Nurses Health Study (1984-2010) and 43 744 men from the Health Professionals Follow-Up Study (1986-2010), 2 large prospective cohort studies. All patients were free of CVD and cancer ...
OBJECTIVE To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association. DESIGN A population-based prospective cohort study. SETTING Nord-Trøndelag County, Norway. PARTICIPANTS A random sample (n=6613) of adults aged 20 years or older in a cohort. METHODS Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in blood samples collected at baseline (n=6377). Mortality was ascertained from the Norwegian National Registry. Cox regression models were applied to estimate the HRs with 95% CIs for all-cause mortality in association with serum 25(OH)D levels after adjustment for a wide spectrum of confounding factors as well as chronic diseases at baseline. RESULTS The median follow-up time was 18.5 years, during which 1539 subjects died. The HRs for all-cause mortality associated with the first quartile level of 25(OH)D (|34.5 nmol/L) as compared with the fourth quartile (≥58.1
Drug utilization evaluation (DUE) is an effective program to identify variability in drug use and to support interventions that will improve patient outcomes. The appropriate use of enoxaparin, a low molecular weight heparin (LMWH), which is widely used as curative or preventive treatment of thromboembolic disorders was assessed in the study. A prospective DUE was carried out at Masih Daneshvari teaching hospital. Criteria for the appropriate use of enoxaparin was used to evaluate prescription and administration patterns in this hospital. Enoxaparin utilization of 147 inpatients was reviewed. A total of 944 variables (70.92%) in the regimen, among all subjects, were rated as appropriate and 382 (28.70%) were rated as inappropriate for the conditions diagnosed. The results of this study showed that inappropriate dosing, administration and prescribing of enoxaparin is rather common in masih hospital. Educational programs and implementation of protocols may be needed in the teaching hospitals to control
© 2016 The Authors Introduction Wide local excision and adjuvant radiotherapy is the standard of care for early breast cancer. For large tumours, however, mastectomy is frequently recommended as conventional breast-conserving techniques often result in poor cosmetic outcomes. Therapeutic mammaplasty (TM) may extend the boundaries of breast-conserving surgery by combining breast reduction and mastopexy techniques with tumour excision, preserving a natural breast shape and avoiding the need for mastectomy. The prevalence of this operative option among surgeons in the UK and its success rate are unknown. The TeaM study is a multicentre prospective study that aims to investigate the practice and outcomes of TM. Methods and analysis Breast centres performing TM will be invited to participate through the research collaborative network and the professional associations. All patients undergoing TM between September 2016 and March 2017 will be included. Demographic, operative, oncological and complication data
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up.. METHOD: We conducted a prospective case-control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores ...
RESULTS: By age 4 years, the cumulative incidence of stuttering onset was 11.2% (95% confidence interval [CI]: 9.7% to 12.8%). Higher maternal education (P = .004), male gender (P = .02), and twinning (P = .005) predicted stuttering onset. At outcome, stuttering children had stronger language (mean [SD]: 105.0 [13.0] vs 99.6 [14.6]; mean difference 5.5, 95% CI: 3.1 to 7.8; P , .001) and nonverbal cognition (mean [SD]: 106.5 [11.4] vs 103.9 [13.7], mean difference 2.6, 95% CI: 0.4 to 4.8; P = .02) and better health-related quality of life but were otherwise similar to their nonstuttering peers. Only 9 of 142 children (6.3%; 95% CI: 2.9% to 11.7%) recovered within 12 months of onset. ...
Rheumatoid arthritis (RA) is a progressive disease, often leading to disability. Because the disease course develops rapidly during the first years after diagnosis, more knowledge is needed about the early disease course to minimize later disability. This thesis describes the course of disability in early RA such as hand function, pain intensity, activity limitation and sick leave. In addition, this thesis compares disability between women and men and compares disability between RA patients and referents.. This thesis is primarily based on data from the 320 patients that were included in the multi-centre project in Sweden called Early interventions in rheumatoid arthritis (TIRA). A wide range of outcome variables was registered between 1996 and 2006 during regular follow-ups from time for diagnosis through the eight-year follow-up. Outcome regarding disease activity and disability of RA patients still remaining in TIRA at the three and five year follow-up respectively are used in this thesis. ...
As part of a project to examine health care ethics consultation in Canada, we surveyed individuals who were considered by themselves or others to play a significant role in health care ethics consultation. Since one goal ...
Risikoforebygging er en viktig del av alt helsearbeid, men det meste av evidens med hensyn på forebyggende helsearbeid er fremkommet ved studier utført på middelaldrende befolkningsgrupper med ulik ekstern validitet, med variabel oppfølgingstid, og med overvekt av menn. Modifiserbare risikofaktorer har potensielt ulik innvirkning i ulike aldersgrupper, i ulike faser av en lengre oppfølgingstid og med hensyn på forskjellige endepunkter (dødelighet: total og årsaksspesifikk). Målsetning: å studere forskjeller og likheter i effekten av livsstilsrelaterte risikofaktorer (særlig kroppsmasseindeks, fysisk aktivitet og lungefunksjon) på total dødelighet og årsaksspesifikk dødelighet som følge av hjerneslag og koronar hjertesykdom i ulike aldersgrupper av menn og kvinner i en generell norsk befolkning med 42 års oppfølgingstid. Materiale og metode: 6811 tilfeldig utvalgte menn og kvinner i alderen 20-79 og bosatt i Bergen i 1964 ble invitert til en utvidet helseundersøkelse etter ...
Purpose: : To study the natural history and the major risk factors of ROP among the infants in Taiwan. Methods: : A prospective natural history study of ROP was performed for all premature infants from June 2010 to July 2011 at our childrens hospital. Patients were screened with birth weight (BW) less than 1500 grams or gestational age (GA) less than 32 weeks or selected infants with BW more than 1500 grams or GA more than 32 weeks with an unstable clinical course, including those requiring cardiorespiratory support and who are believed to be high risk by their pediatrician. The incidence of advanced ROP, the need for laser, Bevacizumab, or vitrectomy treatment was documented. The associated risk factors for the development of ROP were recorded. Results: : We enrolled 223 premature infants, and 98 infants (44%) developed ROP. The mean gestational age (GA) was 29.2 ± 3.0 (range 28-36) weeks and the mean BW was 1247.0 ± 441.5 (range 700-2705) grams. The incidence of ROP among BW more and less ...
Background: Physical activity (PA) is considered a cornerstone of diabetes mellitus management to prevent complications, but conclusive evidence is lacking. Methods: This prospective cohort study and meta-analysis of existing studies investigated the association between PA and mortality in individuals with diabetes. In the EPIC study (European Prospective Investigation Into Cancer and Nutrition), a cohort was defined of 5859 individuals with diabetes at baseline. Associations of leisure-time and total PA and walking with cardiovascular disease (CVD) and total mortality were studied using multivariable Cox proportional hazards regression models. Fixed-and random-effects meta-analyses of prospective studies published up to December 2010 were pooled with inverse variance weighting. Results: In the prospective analysis, total PA was associated with lower risk of CVD and total mortality. Compared with physically inactive persons, the lowest mortality risk was observed in moderately active persons: ...
Welcome to The Academy of Medical Cannabis - the globally leading institute for clinical training and research in cannabis-based medicinal products.
Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. ,300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = ...
Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. ,300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = ...
Abstract Background Few prospective studies on association between waist circumference and hypertension have | Wenshu Luo, Zhirong Guo, Xiaoshu Hu, Zhengyuan Zho | International Journal of Cardiology |
Objective: It has been suggested that lipid-lowering treatment with the use of statins adversely affects the steroid hormones. However, the safety of lipid lowering treatment targeting very low levels of LDL with respect to the steroid hormones has not been established. Research design and methods: A prospective, randomized, multicenter trial was conducted involving 98 patients. The patients were randomized into 2 groups: group-I received 10 mg of atorvastatin plus 10 mg of ezetimibe and group-II 80 mg of atorvastatin for the first 3 months. After crossover, the first group received 80 mg of atorvastatin and the second group 10 mg of atorvastatin plus 10 mg of ezetimibe for the following 3 months. Cortisol, DHEAS, testosterone, and estradiol levels were measured at the enrollment and at the end of the 1(st), 2(nd), 3(rd), and 6(th) months. Results: Along with a decrease in LDL level, the levels of DHEAS, testosterone, and estradiol decreased in both groups ( ...
Poster: EuroSafe Imaging 2019 / ESI-0043 / Influence of BMI on clinical DRLs for CT examinations: a prospective multicenter study after protocol harmonization and optimization. by: H. Brat1, F. Zanca2, B. Rizk3, S. Montandon4, D. Racine5, D. Fournier1; 1Institut de Radiologie de Sion Sion/CH, 2Palindromo Heverlee/BE, 3Centre dImagerie de Fribourg Fribourg/CH, 4Philips Medical Systems Bussigny/CH, 5Institut de Radiophysique Appliquee Lausanne/CH
In this large prospective study among US men and women who were on average age 73 years at baseline, greater walking, leisure-time activity, and exercise intensity were inversely associated with CHD, stroke (especially ischemic stroke), and total CVD. To our knowledge, this is the first large prospective community-based study including a large number of participants ,70 years and having updated PA over time, to demonstrate independent associations of PA measures with lower incidence of CHD, stroke, and total CVD. Results were robust in a range of sensitivity analyses. When different types of PA were simultaneously evaluated, greater walking and, to a lesser extent, exercise intensity were independently associated with lower risk, whereas leisure-time activity was not independently associated with risk.. With aging, the risk of developing and dying of chronic diseases such as CVD increases dramatically.26 In many countries in the world, the proportion of the population ,60 years is increasing ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A total of 36 studies were included, with 1,279,804 subjects and 36,352 CVD cases. Duration of follow-up for incident CVD ranged from 6-44 years, with a median follow-up of 10 years. Twenty-one studies were conducted in Europe, 12 in the United States, and three in Japan. A nonlinear relationship of coffee consumption with CVD risk was identified (p for heterogeneity = 0.09, p for trend < 0.001, p for nonlinearity < 0.001). Compared with the lowest category of coffee consumption (median, 0 cups per day), the relative risk of CVD was 0.95 (95% confidence interval [CI], 0.87-1.03) for the highest category (median, 5 cups per day), 0.85 (95% CI, 0.80-0.90) for the second highest category (median, 3.5 cups per day), and 0.89 (95% CI, 0.84-0.94) for the third highest category (median, 1.5 cups per day). Coffee consumption was nonlinearly associated with both coronary heart disease and stroke risks.. ...
article{8645532, author = {Seibold, Petra and Webb, Adam and Aguado-Barrera, Miguel E. and Azria, David and Bourgier, Celine and Brengues, Muriel and Briers, Erik and Bultijnck, Renée and Calvo-Crespo, Patricia and Carballo, Ana and Choudhury, Ananya and Cicchetti, Alessandro and Claßen, Johannes and Delmastro, Elena and Dunning, Alison M. and Elliott, Rebecca M. and Fachal, Laura and Farcy-Jacquet, Marie-Pierre and Gabriele, Pietro and Garibaldi, Elisabetta and Gómez-Caamaño, Antonio and Gutiérrez-Enríquez, Sara and Higginson, Daniel S. and Johnson, Kerstie and Lobato-Busto, Ramón and Mollà, Meritxell and Müller, Anusha and Payne, Debbie and Peleteiro, Paula and Post, Giselle and Rancati, Tiziana and Rattay, Tim and Reyes, Victoria and Rosenstein, Barry S. and De Ruysscher, Dirk and De Santis, Maria Carmen and Schäfer, Jörg and Schnabel, Thomas and Sperk, Elena and Symonds, R. Paul and Stobart, Hilary and Taboada-Valladares, Begoña and Talbot, Christopher J. and Valdagni, Riccardo ...
PURPOSE: To estimate the prevalence of alcohol use at the age of 10-11 years and document variation by early sociodemographic and concurrent alcohol-s...
Summary of the first prospective study - published online February 13, 2012 in the Journal of Clinical Oncology - to provide strong evidence of increased breast and pancreatic cancer risk in individuals with Lynch syndrome, who carry certain inherited genetic mutations in DNA repair genes. The study is also the first to show that relatives of people with Lynch syndrome who do not carry these mutations have no increased risk of cancer
BACKGROUND: Caffeine intake has been inversely associated with Parkinsons disease (PD) risk. This relationship may be modified by polymorphisms of glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and cytochrome P450 1A2 (CYP1A2), but the results of previous studies have been inconsistent. METHOD: We examined the interaction of caffeine intake with GRIN2A-rs4998386 and CYP1A2-rs762551 polymorphisms in influencing PD risk among 829 incident cases of PD and 2,754 matched controls selected among participants in the following 3 large prospective ongoing cohorts: the Nurses Health Study, the Health Professionals Follow-up Study, and the Cancer Prevention Study II Nutrition Cohort ...
International Journal of Pharmacy and Pharmaceutical Research (IJPPR) will give best paper award every year in the form of money along with certificate to support research activity of scholar ...
Clinical Trials - clinicaltrials.gov To determine if H.P. Acthar Gel (repository corticotrophin) has the same anti-proteinuric effects seen with the synthetic A...
IMPRESS 2 Study: International Multicentric prospective study on PREgnancy in Systemic Sclerosis Patients with systemic sclerosis who plan a pregnancy for the years 2013-16 may be interested in participating in an international observational prospective study initiated by EUSTAR on pregnancy in wome...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Mainly Im working on cancer epidemiology, especially in nutritional factors, in genetic factors that contribute to carcinogenesis. I work with a large European cohort called EPIC, the European Prospective Investigation of Cancer and Nutrition, which has sampled half a million Europeans at baseline, so when everyone was healthy. Then we follow these people up over the intervening years to find out what kind of cancers they develop. That gives us the chance to closely match them with other people in the cohort who didnt develop these cancers and so, very important, we can have this very close case-controlled matching. Because the samples were taken before diagnosis this helps to minimise issues to do with reverse causality, the fact that things go awry when you have a disease, so its very difficult to say whether these factors are implicated in the disease or theyre just because you have a disease. So this is the power of this kind of study design, prospective cohort.. What are the results so ...
A study suggests that smoking and heavy drinking can make a person look older than his/her actual age. Heavy drinking and smoking are linked to visible signs of physical ageing and the consequences reflect on a persons face, sooner or later. Light to moderate drinking is not associated with looking older than ones years, the findings showed. "This is the first prospective study to show that alcohol and smoking are associated with the development of visible age-related signs and thus generally looking older than ones actual age," said the researchers. The findings are based on information from more than 11,500 adults in Denmark whose heart health and visible ageing signs were tracked for an average of 11.5 years as part of the Copenhagen City Heart Study. Before each of the clinic visits, researchers quizzed the participants about their lifestyle and general health and asked to state how much they drank and smoked. And they were checked for four signs of ageing that have previously been linked ...
TY - JOUR. T1 - A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). AU - Anker, Stefan D.. AU - Coats, Andrew J.S.. AU - Cristian, Gabriel. AU - Dragomir, Dinu. AU - Pusineri, Enrico. AU - Piredda, Massimo. AU - Bettari, Luca. AU - Dowling, Robert. AU - Volterrani, Maurizio. AU - Kirwan, Bridget Anne. AU - Filippatos, Gerasimos. AU - Mas, Jean Louis. AU - Danchin, Nicolas. AU - Solomon, Scott D.. AU - Lee, Randall J.. AU - Ahmann, Frank. AU - Hinson, Andy. AU - Sabbah, Hani N.. AU - Mann, Douglas L.. PY - 2015/9/7. Y1 - 2015/9/7. N2 - Aims AUGMENT-HF was an international, multi-centre, prospective, randomized, controlled trial to evaluate the benefits and safety of a novel method of left ventricular (LV) modification with alginate-hydrogel. Methods Alginate-hydrogel is an inert permanent implant that is directly injected into LV heart muscle and ...
Original Article Pak Armed Forces Med J 2015; 65(Suppl): S ANALYSIS OF KEY PERFORMANCE INDICATORS AND QUALITY OBJECTIVES OF A TERTIARY CARDIAC CENTER Muhammad Bilal Maqsood, Sabeen Khurshid Zaidi,