TY - JOUR. T1 - A multicenter prospective cohort study to develop frailty-based prognostic criteria in heart failure patients (FLAGSHIP). T2 - Rationale and design. AU - on behalf of the FLAGSHIP collaborators. AU - Yamada, Sumio. AU - Adachi, Takuji. AU - Izawa, Hideo. AU - Izawa, Hideo. AU - Kondo, Takaaki. PY - 2018/8/2. Y1 - 2018/8/2. N2 - Background: Heart failure (HF) and frailty often co-exist, and frailty in HF results in a poor prognosis. However, in Asian populations, prognostic criteria are needed to examine the effect of frailty on HF. Therefore, we conducted a nationwide cohort study to develop frailty-based prognostic criteria in HF patients (FLAGSHIP). FLAGSHIP mainly aims to 1) develop the frailty criteria based on HF-specific outcomes, 2) propose a hypothesis of the potential mechanisms of frailty manifestations in HF, and 3) examine the effects of outpatient cardiac rehabilitation on frailty. Methods: In this prospective study, we consecutively enroll ambulatory patients ...
Observational Prospective Study to Evaluate AEs, Risk Factors and Drug Utilization of BUSCAPINA COMPOSITUM N in Adults From Metropolitan Lima
TY - THES. T1 - Respiratory pathogens and morbidity in the first year following very preterm birth: A 12-month prospective cohort study. AU - Townsi, Nada. PY - 2019. Y1 - 2019. N2 - This thesis prospectively characterises respiratory morbidity and respiratory pathogens in survivors of very preterm birth, less than 32 weeks gestation, for one year after hospital discharge using monthly respiratory questionnaire and parent-collected nasal swabs. Very preterm infants, irrespective of neonatal lung disease, experience a high burden of respiratory symptoms with 60.7% having recurrent wheeze (more than 3 episodes) during this time. Respiratory pathogens, most commonly rhinovirus, were readily detected during both symptomatic and asymptomatic assessments. Consequently, prescription of respiratory medications and healthcare utilisation were high. Further research is warranted to determine the long-term impacts of respiratory pathogens on respiratory health later in life. AB - This thesis prospectively ...
Pap screening, an effective method for cervical cancer prevention, is now supported by molecular human papillomavirus (HPV) testing. Recently commercialised preventive vaccines also provide new tools for the primary prevention of cervical cancer. To determine appropriate prevention strategies, the Health General Direction, Lombardy Region, funded a project that aims to characterize and monitor HPV infections and related cervical diseases in high-risk women.
Hayashi K, Milloy MJ, Wood E, Dong H, Montaner JS, Kerr T Predictors of liver-related death among people who inject drugs in Vancouver, Canada: a 15-year prospective cohort study Journal of the International AIDS Society PubMed. ...
A Prospective Observational Study on Pattern, Severity and Outcome of Different Poisoning Cases in a Tertiary Care Hospital, India, Vijay Mate
Out-of-hours care in the primary care setting is rapidly changing and evolving towards general practitioner cooperatives (GPC). GPCs already exist in the Netherlands, the United Kingdom and Scandinavia, all countries with strong general practice, including gatekeepers role. This intervention study reports the use and caseload of out-of-hours care before and after implementation of a GPC in a well subscribed region in a country with an open access health care system and no gatekeepers role for general practice. We used a prospective before/after interventional study design. The intervention was the implementation of a GPC. One year after the implementation of a GPC, the number of patient contacts in the intervention region significantly increased at the GPC (OR: 1.645; 95% CI: 1.439-1.880), while there were no significant changes in patient contacts at the Emergency Department (ED) or in other regions where a simultaneous registration was performed. Although home visits decreased in all general
Mitochondrial function of immune cells in septic shock: A prospective observational cohort study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Authors: Maria Pellise, Nicholas G Burgess, Nicholas Tutticci, Luke F Hourigan, Simon A Zanati, Gregor J Brown, Rajvinder Singh, Stephen J Williams, Spiro C Raftopoulos, Donald Ormonde, Alan Moss, Karen Byth, Heok PNg, Hema Mahajan, Duncan McLeod, Michael J Bourke
Background and purpose: About 20% of patients with acute ischemic stroke experience symptom progression resulting in poor outcome. We have evaluated the effect of cilostazol compared with aspirin on preventing acute symptom progression, and on clinical outcome.. Methods: A multi-center, open, randomized, prospective comparative study conducted from April 2009 to March 2011. Inclusion criteria: non-cardioembolic ischemic stroke admitted within 48 hours of onset, neurologically stable, and with written informed consent. Exclusion criteria: contraindicated or previous exposure to aspirin and/or cilostazol. Patients were administered either cilostazol 200 mg daily (group C) or aspirin 200 mg daily (group A) within 48 hours of onset. Primary endpoint: occurrence of acute symptom progression (ΔNIHSS ≥2) within 7 days. Secondary endpoints: 3-month outcome (mRS 0-2), occurrence of vascular events (ischemic stroke, brain hemorrhage, myocardial infarction), bleeding events, and other adverse events. ...
Methods Prospective data on 204 lactating mothers of a healthy term singleton infant (normal pregnancy, labor and delivery) on day 2 after delivery. Exclusion: preterm and postterm infants, maternal treatment with antidepressant, anticonvulsants, or magnesium sulfate, previous breast surgery, opiates for analgesia; infants with major congenital malformations, or neonatal complications. Anthropometrics included: inter-nipple distance, nipple length, and horizontal and vertical diameters; cup size (best fit to a lactation bras); infant goniomaxillary length/gonio-mandibular length (GMxL/GMnL) ratio and intercommissural distance. A latch score was performed after measurements. Data collected included gravidity, parity, gestational age, previous breast feeding experience, and early breast feeding (,2 hours after delivery). Backward stepwise regression analysis was used to study the combined effect of several independent variables upon latch score. ...
Indexed/Abstracted in: Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), ...
Multigenic approaches have been demonstrated to be valid tools for identifying subjects at risk for complex traits, such as type 2 diabetes (17) and coronary artery disease (18). A similar strategy was used in the present study, hypothesizing that, in subjects with type 2 diabetes, an increasing number of proinflammatory alleles may confer a significant risk of developing ischemic stroke. We have previously demonstrated the utility of the Go-DARTS cohort to study the contribution of gene variations to cardiovascular risk in subjects with diabetes (14-16). To our knowledge, this is the first prospective study that attempts to look at the impact of the combined effect of multiple gene variations on incident stroke. It is also the first prospective study considering the combination of multiple inflammatory SNPs in diabetic individuals.. The decision to study the rs1800795, rs5498, rs5361, rs1024611, and rs679620 of the IL-6, MCP-1, ICAM-1, sel-E, and MMP-3 genes was based on the following criteria. ...
Objective-To examine the relation between resting heart rate and new major ischaemic heart disease events in middle aged men with and without pre-existing ischaemic heart disease. Design-Prospective study of a cohort of men with eight years follow up for cardiovascular morbidity and mortality for all men. Setting-General practices in 24 British...
Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics of MS associated with worse COVID-19 outcomes. Therefore, we conducted a multicenter prospective cohort study looking at the outcomes of 40 MS patients with confirmed COVID-19. Severity of COVID-19 infection was based on hospital course, where a mild course was defined as the patient not requiring hospital admission, moderate severity was defined as the patient requiring hospital admission to the general floor, and most severe was defined as requiring intensive care unit admission and/or death. 19/40(47.5%) had mild courses, 15/40(37.5%) had moderate courses, and 6/40(15%) had severe courses. Patients with moderate and severe courses were significantly older than those with a mild course (57[50-63] years old and 66[58.8-69.5] years old vs 48[40-51.5] years old, P = ...
Tolerability of Shortened Infliximab Infusion in Scheduled Maintenance Therapy for IBD: a Prospective Multi-center European Cohort Study
To analyze the impact of multimorbidity (MM) on health care costs taking into account data heterogeneity. Data come from a multicenter prospective cohort study of 1,050 randomly selected primary care patients aged 65 to 85 years suffering from MM in Germany. MM was defined as co-occurrence of ≥3 conditions from a list of 29 chronic diseases. A conditional inference tree (CTREE) algorithm was used to detect the underlying structure and most influential variables on costs of inpatient care, outpatient care, medications as well as formal and informal nursing care. Irrespective of the number and combination of co-morbidities, a limited number of factors influential on costs were detected. Parkinsons disease (PD) and cardiac insufficiency (CI) were the most influential variables for total costs. Compared to patients not suffering from any of the two conditions, PD increases predicted mean total costs 3.5-fold to approximately € 11,000 per 6 months, and CI two-fold to approximately € 6,100. The high
Patients with chronic renal failure show a greater incidence of malignancies. We evaluated whether moderately impaired renal function at baseline influenced risk of all cancers during long-term follow in young persons. Our cohort included 33,346 subjects, aged 26-61 years at baseline, in a representative, population-based study enrolling subjects from 1974 to 1992. Median follow-up time was 28 years. Plasma creatinine was analyzed as a single measure at baseline. Incident cases of cancer were identified from the Swedish Cancer Registry. We studied 24,552 subjects from the cohort. To account for the unique sampling design, participants were divided by sex and age at baseline into 1,132 older men (age 60), 14,254 younger men (age 40-52), 7,498 older women (age 47-57) and 1,688 younger women (age 35-43). Glomerular filtration rate (GFR) was estimated using the CKD-EPI formula. Patients were classified as having either normal to mildly impaired kidney function (eGFR ≥ 60 mL/min/1.73 m2), or moderate
Supplementary MaterialsSupplementary materials 1 (DOCX 637 KB) 392_2019_1424_MOESM1_ESM. not analyzed. The medial and lateral plots and by the KolmogorovCSmirnov test. Normally and non-Gaussian distributed variables were reported as mean (SD) or median (interquartile range), respectively. All biomarker levels were log10 transformed and normalised to 1 1 SD increment. Normalised data were analysed using ANOVA and general linear models, and values were Bonferroni-corrected for multiple comparisons. Non-Gaussian data and categorical variables were analysed using non-parametric tests [MannCWhitney test, KruskalCWallis test and Spearman (value(%) and imply (SD) or median (Interquartile range) are reported. beliefs are quoted for the ANOVA/Kruskal Chi or Wallis squared exams for constant or categorical factors, respectively angiotensin 2 receptor blocker Relationship evaluation PENK was correlated to age group (rating of log natriuretic peptides (0.437, nonsignificant). Open up in another home window ...
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In the frame of multicenter research studies, biobanks ensure the harmonization and traceability of the prospective collection of quality samples. This is significant because pre-analytical variables must be carefully considered to guarantee the integrity of biomarkers to be tested and to avoid bias affecting the validity of the analytical results. According to a quality management system, biobanks contribute with documents and records; consumable preparation for collection, processing, and conservation; sample quality controls; and centralized management of sample handling, storage, and distribution. Traceability of samples is based on unique standard codes and the use of pre-assigned, pre-coded, and pre-labeled materials for sample collection, processing, and conservation. By using these supporting tools, quality derivatives are obtained based on common and evidence-based standard operating procedures (SOPs), with associated traceability information in relation with their collection, processing,
Langdorf MI, Medak AJ, Hendey GW, Nishijima DK, Mower WR, Raja AS, Baumann BM, Anglin DR, Anderson CL, Lotfipour S, Reed KE, Zuabi N, Khan NA, Bithell CA, Rowther AA, Villar J, Rodriguez RM. Prevalence and Clinical Import of Thoracic Injury Identified by Chest Computed Tomography but Not Chest Radiography in Blunt Trauma: Multicenter Prospective Cohort Study. Ann Emerg Med. 2015 Dec;66(6):589-600. doi: 10.1016/j.annemergmed.2015.06.003. Epub 2015 Jul 11. PubMed PMID: 26169926 ...
The goal of the initial 3-year effort of this overall project is to develop and test a framework for establishing a long-term fire fighter multicenter prospective cohort study focused on carcinogenic exposures and effects. This information is essential to guide interventions to reduce the most important carcinogenic exposures and develop treatment options to potentially reverse carcinogenic effects in their early stages. ...
OBJECTIVE--To examine the associations between air temperature and risk factors for ischaemic heart disease. METHOD--Data on risk factors are available from up to 2036 men in the Caerphilly Prospective Heart Disease Study. Daily temperatures were obtained from the Meteorological Office. Relations between these were examined by regression. RESULTS--The coldest month of the year has a mean temperature that is 16 degrees C lower than that in the warmest month. A fall in temperature of this magnitude is associated with higher blood pressures (by 3-5 mm Hg) and a lower concentration of high density lipoprotein cholesterol (by 0.08 mmol/l). The most important effects however, seem to be on the haemostatic system. Fibrinogen is 0.34 g/l higher in the coldest month than in the warmest (p , 0.001) and alpha 2 macroglobulin, a protein that inhibits fibrinolysis, is also raised. Platelet count is increased by 30% of a standard deviation and the sensitivity of platelets in whole blood to adenosine ...
The association between dietary Fe intake and diabetes risk remains inconsistent. We aimed to explore the association between dietary Fe intake and type 2 diabetes mellitus (T2DM) risk in middle-aged and older adults in urban China. This study used data from the Guangzhou Nutrition and Health Study, an on-going community-based prospective cohort study. Participants were recruited from 2008 to 2013 in Guangzhou community. A total of 2696 participants aged 40-75 years without T2DM at baseline were included in data analyses, with a median of 5·6 (interquartile range 4·1-5·9) years of follow-up. T2DM was identified by self-reported diagnosis, fasting glucose ≥ 7·0 mmol/l or glycosylated Hb ≥ 6·5 %. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95 % CI. We ascertained 205 incident T2DM cases during 13 476 person-years. The adjusted HR for T2DM risk in the fourth quartile of haem Fe intake was 1·92 (95 % CI 1·07, 3·46; P trend = 0·010), compared with the ...
View Poster. INTRODUCTION. Multiple surgical techniques have been proposed for patients with clinically significant PD. The technique of grafting with hemostatic self-adhesive fleece of collagen-fibrinogen-thrombin has been popularized in Europe (single surgeon, single institution) with potential advantages (shorter surgery duration, less technically demanding procedure and relatively cheaper than other graft materials). However, there is no prospective or multicenter evidence to evaluate the outcomes of this technique. Our aim is to evaluate the preliminary outcomes in patients who underwent this technique in 11 Spanish centers after 16 months of recruiting.. METHODS. Between July 2016 and October 2017, 43 patients underwent surgery in 11 Spanish centers using the previously described technique. Preoperative, intraoperative and post-surgical data were collected prospectively and follow up at 3 and 6 months with questionnaires (PDQ, EHS, IIEF-5 and satisfaction) was performed. All patients ...
To determine the time course of development of resistance to atevirdine mesylate ( U-87201E ) in patients with HIV isolates showing in vitro resistance to zidovudine ( AZT ). To determine the genotype changes in HIV reverse transcriptase associated with in vitro AZT resistance to U-87201E. To determine the genotype and phenotype effects of treatment with a nondideoxynucleoside agent on the alterations of the HIV-1 population associated with in vitro AZT resistance. To determine whether serial passage of patient pre-drug HIV isolates in the presence of U-87201E will generate the resistant mutants that may subsequently emerge in the patients ...
This page contains the abstract Morbidity and Mortality of Major Adult Spinal Surgery. A Prospective Cohort Analysis of 942 Consecutive Patients http://www.chiro.org/LINKS/ABSTRACTS/Morbidity_and_Mortality_of_Major_Adult.shtml
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism Journal Articles Refereed ...
Prospective studies are key study designs when attempting to unravel health mechanisms that are widely applicable. Understanding the internal validity of a prospective study is essential to judge a studys quality. Moreover, insights in possible sampling bias and the external validity of a prospective study are useful to judge the applicability of a studys findings. We evaluated participation, retention, and associated factors of women in a multicenter prospective cohort (FemCure) to understand the studys validity.Chlamydia trachomatis (CT) infected adult women, negative for HIV, syphilis, and Neisseria gonorrhoeae were eligible to be preselected and included at three sexually transmitted infection (STI) clinics in the Netherlands (2016-2017). The planned follow-up for participants was 3 months, with two weekly rectal and vaginal CT self-sampling and online questionnaires administered at home and at the clinic. We calculated the proportions of preselected, included, and retained (completed ...
This study is the first to document the population incidence in the UK of SUPC in infants who were assessed as being healthy at birth. The incidence (0.05/1000 term live births) is consistent with case, regional and national series, suggesting an incidence ranging from between 0.026/1000 live births in the first 24 h of birth10 to 0.27/1000 where collapse occurs within 3 days of birth.2 The overall BPSU respondent rate (94.6% for 2008) is higher than any equivalent UK scheme and ranks highly against other national paediatric surveillance units. However, complete ascertainment of all cases of SUPC occurring within the study period could not be verified. This was due to the complexity of the case definition and the heterogeneity that exists in the classification of such infant deaths, which precluded cross-checking against national and regional databases. As such, the incidence in this study may be an underestimate.. One third of infants had an underlying condition leading to collapse and a ...
Background Multiple Sclerosis (MS) is the most common cause of neurological disability in young and middle-aged adults. At this stage in life most people are in the midst of their working career. The...
Context: Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. Objective: To characterize the natural course of depressive symptoms among older women (from the young old to the oldest old) followed up for almost 20 years. Design: Using latent-class growth-curve analysis, we analyzed women enrolled in an ongoing prospective cohort study (1988 through 2009). Setting: Clinic sites in Baltimore, Maryland; Minneapolis, Minnesota; the Monongahela Valley near Pittsburgh, Pennsylvania; and Portland, Oregon. Participants: We studied 7240 community-dwelling women 65 years or older. Main Outcome Measure: The Geriatric Depression Scale short form (score range, 0-15) was used to routinely assess depressive symptoms during the follow-up period. Results: Among older women, we identified 4 latent classes during 20 years, with the predicted probabilities of group membership totaling 27.8% with ...
Jeffrey Moses, MD, presents results from PROTECT III, the largest prospective study of Impella for high-risk PCI in the real world.
This study represents the largest prospective series of febrile children returning from the tropics. We have identified a high proportion of treatable conditions, and highlighted the importance of common cosmopolitan infections as well as exotic illnesses presenting with fever in this population. The majority of diagnoses requiring medical treatment were made using simple investigations.. Previous studies of imported infections have concentrated on adult travellers presenting to tertiary centres,6 often returning from Sub-Saharan Africa.4,5 Our study population, being largely South Asian, is therefore very different. Most imported malaria from the Indian subcontinent is caused by Plasmodium vivax, as in our study.9 Only 30% of children with this type of malaria present within a month of return.9 Imported malaria from Africa is mostly P falciparum, a potentially life threatening infection. This mostly presents within one month of return.9. Many new arrivals from Africa will stay in the South East ...
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The majority of youth with type 1 diabetes are above hemoglobin A1c (HbA1c) targets. Continuous glucose monitoring (CGM) has been shown to improve clinical outcomes, and use early in the course of diabetes has the potential to improve glycemic outcomes and improve quality of life.. In our clinic, youth with new-onset type 1 diabetes were offered the opportunity to start on CGM (Dexcom G6) soon after diabetes diagnosis. Ongoing CGM coverage was subsequently applied for through the patients insurance. Following CGM initiation, youth had a 1-week follow-up with a nurse practitioner. Per clinic standard of care, youth were seen again at 1 month post-diagnosis and every 3 months thereafter. We prospectively collected data on HbA1c, continued CGM use, days of CGM wear, method of viewing CGM data, time in range (TIR), and time in hypoglycemia. Institutional review board approval was obtained for the prospective data collection.. From July 2018 to April 2019, we approached 44 youth with newly diagnosed ...
Data presented as median (interquartile range). P value by Kruskall-Wallis. Intergroup differences by Mann Whitney. +P value significantly higher in fentanyl group compared to morphine group (p,0.05). N.S=Non Significant ...
Bernard Dubray, Muriel Garcia-Ramirez, Robert Apardian. [The case for a national prospective study on radiation therapy-induced lung toxicity]. Cancer Radiothérapie, Elsevier Masson, 2008, 12 (2), pp.134-5. ⟨10.1016/j.canrad.2007.11.009⟩. ⟨inserm-00467281⟩ ...
To our knowledge, this is the first prospective study in which BF and metabolism were measured in parallel using [15O]H2O and [18F]FDG PET/CT in patients presenting with suspicion of pancreatic cancer. We found average BF to be significantly decreased and metabolism significantly increased in malignant pancreatic lesions compared with normal pancreas. Based on our initial findings, we hypothesize that a high ratio of metabolism to BF may predict survival better than either functional measurement alone.. At a time when the possibilities and limitations (22) of new therapeutic agents targeting angiogenic mechanisms of tumors are being recognized, it is becoming obvious that careful classification and selection of patients prior to treatment is necessary for these therapeutic strategies to be successful. This is of particular importance in malignancies with a low likelihood of response, such as pancreatic cancer (6). In this respect, tumor perfusion and metabolism seem to be among the most relevant ...
De HvA inspireert studenten om met creatieve oplossingen en duurzame innovaties aan de toekomst te werken; om vandaag te verbinden met morgen.
Following this initial letter, two subsequent case series have been published supporting the peripheral-IJ as a reasonable alternative for temporary venous access. The first case series of 9 patients placed them in patients with unobtainable IV access [2]. 64 mm angiocatheters were used to cannulate the IJ under ultrasound guidance using the above-described technique. All catheters were labeled for removal within 72 hrs. All patients were followed up via chart review one year later. Two of 9 catheters failed due to kinking within the first 48 hrs. There were no apparent adverse outcomes in any patient including deep vein thrombosis, bacteremia, endocarditis or pneumothorax. A second group conducted a prospective case series in which 9 patients underwent placement of a peripheral IJ (PIJ), when other access could not be obtained and the patient did not initially require a central line [3]. The authors attempted follow-up with all patients within a week. On follow-up, the seven patients who ...
Use the SQL Server aggregate function IQR to calculate inter-quartile range. Documentation on over 260 SQL Server statistical functions including examples that can be copied directly into SSMS.
To characterize the PK of IgG following intravenous IgPro10 dosing in Japanese PID subjects after a standard wash-in/wash-out period of 12 weeks.
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OBJECTIVES--To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN--Prospective study of a cohort of men followed up for 9.5 years. SETTING--General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS--Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general practice in each of 24 towns, were studied. MAIN OUTCOME MEASURES--Fatal and nonfatal ischaemic heart disease events. RESULTS--Risk of major ischaemic heart disease events was significantly increased at haematocrit levels of , or = 46.0%. Men with raised haematocrit (, or = 46.0%) showed a 30% increase in relative risk (RR) of major ischaemic heart disease events (RR = 1.32; 95% confidence intervals (CI) 1.10,1.57, p , 0.01) compared with those with values below 46.0%, even after adjustment for age, social class, smoking, body mass index, physical activity, blood cholesterol, lung function (FEV1), and ...
TY - JOUR. T1 - Workplace social capital and the onset of major depressive episode among workers in Japan. T2 - A 3-year prospective cohort study. AU - Sakuraya, Asuka. AU - Imamura, Kotaro. AU - Inoue, Akiomi. AU - Tsutsumi, Akizumi. AU - Shimazu, Akihito. AU - Takahashi, Masaya. AU - Totsuzaki, Takafumi. AU - Kawakami, Norito. PY - 2017/6/1. Y1 - 2017/6/1. N2 - Background This study examined the prospective association of workplace social capital (WSC) with major depressive episode (MDE) among Japanese employees. Methods A 3-year prospective cohort study was conducted among 1058 employees from a private thinktank company who participated in a baseline survey; after excluding those with MDE in the past 12 months, 929 were followed up. WSC at baseline was measured using a 3-item scale. MDE was assessed at baseline and at follow-up every year, by using a web-based, selfadministered version of the WHO Composite International Diagnostic Interview (WHO-CIDI) 3.0 depression section, based on the ...
Fertility and pregnancy issues are of key importance for young breast cancer patients. Despite several advances in the field, there are still multiple unmet needs and barriers in discussing and dealing with these concerns. To address the significant challenges related to fertility and pregnancy issues, the PREgnancy and FERtility (PREFER) study was developed as a national comprehensive program aiming to optimize care and improve knowledge around these topics. The PREFER study is a prospective cohort study conducted across several Italian institution affiliated with the Gruppo Italiano Mammella (GIM) group evaluating patterns of care and clinical outcomes of young breast cancer patients dealing with fertility and pregnancy issues. It is composed of two distinctive studies: PREFER-FERTILITY and PREFER-PREGNANCY. The PREFER-FERTILITY study is enrolling premenopausal patients aged 18-45 years, diagnosed with non-metastatic breast cancer, who are candidates to (neo)adjuvant chemotherapy and not previously
Grieving relatives can suffer from numerous consequences like anxiety, depression, post-traumatic stress disorder (PTSD) symptoms, and prolonged grief. This study aims to assess the psychological consequences of grieving relatives after patients death in French palliative care units and their needs for support. This is a prospective observational multicenter mixed study. Relatives of adult patients with a neoplasia expected to be hospitalized more than 72 h in a palliative care unit for end-of-life issues will be included within 48 h after patient admission. End-of-life issues are defined by the physician at patient admission. Relatives who are not able to have a phone call at 6-months are excluded. The primary outcome is the incidence of prolonged grief reaction defined by an ICG (Inventory Complicate Grief) | 25 (0 best-76 worst) at 6 months after patient death. Prespecified secondary outcomes are the risk factors of prolonged grief, anxiety and depression symptoms between day 3 and day 5 and at 6
TY - JOUR. T1 - Predictive validity of weekly monitoring of wound status using DESIGN-R score change for pressure ulcer healing. T2 - A multicenter prospective cohort study. AU - Iizaka, Shinji. AU - Sanada, Hiromi. AU - Matsui, Yuko. AU - Furue, Masutaka. AU - Tachibana, Takao. AU - Nakayama, Takeo. AU - Sugama, Junko. AU - Furuta, Katsunori. AU - Tachi, Masahiro. AU - Tokunaga, Keiko. AU - Miyachi, Yoshiki. PY - 2012/7. Y1 - 2012/7. N2 - There are few studies on predictive validity of methods to monitor the healing process of pressure ulcers. We evaluated whether the change of DESIGN-R (rating) score could predict subsequent healing, and determined the optimal cutoff points. In a multicenter prospective cohort study, patients were followed until wound healing or censoring. Wound severity was evaluated by the DESIGN-R tool every week, and the score change was calculated over 1-4 weeks (n = 411, 286, 224, and 170, respectively). In the multivariate analyses stratified by depth, a one-point ...
Synergistic effects of Vitamin D and magnesium in non-specific low back ache (nLBA) - A prospective comparative study - IJOR- Print ISSN No: - 2581-8112 Online ISSN No:- 2581-9151 Article DOI No:- 10.18231/j.ijor.2021.007, IP International Journal of Orthopaedic Rheumatology-IP Int J Orthop Rheumatol
Objective: To report adverse events (AEs) seen in a large cohort of patients with Juvenile Idiopathic Arthritis (JIA) treated with TNFα blockers (Infliximab and Etanercept).. Methods: All JIA patients treated with Infliximab or Etanercepet at the Paediatric Rheumatologic Centre of the G. Pini Institute (Milan) from November 1999 to February 2006, were enrolled in an open, monocenter, long-term prospective study.. Results: 163 patients (68 Infliximab, 95 Etanercept) were enrolled. Mean onset age 6.4±4.8 years, mean age 17.19.2 years, mean therapy duration 22.9±17.6 months. 45 patients (32 Infliximab, 13 Etanercept) failed to respond to or did not tolerate the first biologic and switched to a second one. 208 treatments (81 Infliximab, 127 Etanercept) were done. 71 AEs occurred in 51 (62.9%) Infliximab patients and led to discontinuation in 26 (32.1%). 133 AEs occurred in 69 (54.3%) Etanercept patients and led to discontinuation in 18 (14.2%). Some AEs, such as thrombocytopenia, ...
TY - JOUR. T1 - A dose-response meta-analysis of the impact of body mass index on stroke and all-cause mortality in stroke patients. T2 - a paradox within a paradox. AU - Bagheri, M.. AU - Speakman, J. R.. AU - Shabbidar, S.. AU - Kazemi, F.. AU - Djafarian, K.. N1 - Acknowledgements We thank Dr. Nicola Orsini for helping us with the statistical analysis. This study was supported by Tehran University of Medical Sciences.. PY - 2015/5. Y1 - 2015/5. N2 - The obesity paradox is often attributed to fat acting as a buffer to protect individuals in fragile metabolic states. If this was the case, one would predict that the reverse epidemiology would be apparent across all causes of mortality including that of the particular disease state. We performed a dose-response meta-analysis to assess the impact of body mass index (BMI) on all-cause and stroke-specific mortality among stroke patients. Data from relevant studies were identified by systematically searching PubMed, OVID and Scopus databases and were ...
TY - JOUR. T1 - Re. T2 - the natural history of penile length after radical prostatectomy: a long-term prospective study.. AU - Morey, Allen F.. PY - 2013/8. Y1 - 2013/8. UR - http://www.scopus.com/inward/record.url?scp=84887337808&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84887337808&partnerID=8YFLogxK. M3 - Article. C2 - 23845350. AN - SCOPUS:84887337808. VL - 190. SP - 592. JO - Journal of Urology. JF - Journal of Urology. SN - 0022-5347. IS - 2. ER - ...
Jehan, I., Harris, H., Salat, S., Zeb, A., Mobeen, N., Pasha, O., ... Goldenberg, R. L. (2009). Neonatal mortality, risk factors and causes: A prospective population-based cohort study in urban Pakistan. Bulletin of the World Health Organization, 87(2), 130-138. DOI: 10.2471/BLT.08.050963 ...
OBJECTIVES: If proven acceptable, safe and effective, the diaphragm could be used as a female-controlled method of preventing both sexually-transmitted infections (STIs) and pregnancy. This studys aim was to assess the acceptability and safety of the diaphragm among sexually-active women in Mombasa, Kenya. METHODS: We conducted a 6-month prospective study among female sex workers (FSWs), and women attending sexual and reproductive health services. Diaphragm acceptability was assessed using continuation rates and factors associated with acceptability. Safety evaluations included colposcopy findings and incidence of urinary tract infections (UTIs) and STIs. RESULTS: Half the 185 participants were FSWs who had less schooling and were less likely to be married than other women. After 6 months, 55% (56/102) of sexually-active women reported having used the diaphragm each sex act during the preceding month. Women liked using the diaphragm (95%, 104/109), and 96% (125/130) reported willingness to ...
TY - JOUR. T1 - Risk factors of nonunion after acute osteoporotic vertebral fractures. T2 - A prospective multicenter cohort study. AU - Inose, Hiroyuki. AU - Kato, Tsuyoshi. AU - Ichimura, Shoichi. AU - Nakamura, Hiroaki. AU - Hoshino, Masatoshi. AU - Togawa, Daisuke. AU - Hirano, Toru. AU - Tokuhashi, Yasuaki. AU - Ohba, Tetsuro. AU - Haro, Hirotaka. AU - Tsuji, Takashi. AU - Sato, Kimiaki. AU - Sasao, Yutaka. AU - Takahata, Masahiko. AU - Otani, Koji. AU - Momoshima, Suketaka. AU - Yuasa, Masato. AU - Hirai, Takashi. AU - Yoshii, Toshitaka. AU - Okawa, Atsushi. N1 - Funding Information: Acknowledgment date: August 30, 2019. First revision date: October 6, 2019. Second revision date: November 13, 2019. Acceptance date: December 16, 2019. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be ...
BÜHLMANN fCAL® ELISA Citation: Beswick, L. et al. Exploration of predictive biomarkers of early infliximab response in acute severe colitis: A prospective pilot study. Journal of Crohns and Colitis. 2017 Nov 7. DOI: 10.1093/ecco-jcc/jjx146. PMID: 29121178 . Highlight from this Publication
TY - JOUR. T1 - Erratum. T2 - A prospective study evaluating the accuracy of using combined clinical factors and candidate diagnostic markers to refine the accuracy of thyroid fine needle aspiration biopsy (Surgery (2010) 148:6 (1170-1177)). AU - Mathur, Aarti. AU - Weng, Julie. AU - Moses, Willieford. AU - Steinberg, Seth M.. AU - Rahabari, Reza. AU - Kitano, Mio. AU - Khanafshar, Elham. AU - Ljung, Britt Marie. AU - Duh, Quan Yang. AU - Clark, Orlo H.. AU - Kebebew, Electron. PY - 2012/2/1. Y1 - 2012/2/1. UR - http://www.scopus.com/inward/record.url?scp=84855798443&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84855798443&partnerID=8YFLogxK. U2 - 10.1016/j.surg.2011.12.039. DO - 10.1016/j.surg.2011.12.039. M3 - Comment/debate. AN - SCOPUS:84855798443. VL - 151. JO - Surgery. JF - Surgery. SN - 0039-6060. IS - 2. ER - ...
Clinical trial for Mother to Child Transmission of HIV , Prospective Observational Cohort Study on Mother to Child Transmission HIV1/HIV2 and Prevention
Objective To independently evaluate the performance of the QRISK score for predicting 10 year risk of cardiovascular disease in an independent UK cohort of patients from general practice and compare the performance with Framingham equations.. Design Prospective open cohort study.. Setting 274 practices from England and Wales contributing to the THIN database.. Participants 1.07 million patients, registered between 1 January 1995 and 1 April 2006, aged 35-74 years (5.4 million person years) with 43 990 cardiovascular events.. Main outcome measures First diagnosis of cardiovascular disease (myocardial infarction, coronary heart disease, stroke, and transient ischaemic attack) recorded in general practice records.. Results This independent validation indicated that QRISK offers an improved performance in predicting the 10 year risk of cardiovascular disease in a large cohort of UK patients over the Anderson Framingham equation. Discrimination and calibration statistics were better with QRISK. QRISK ...
In 1986 a prospective cohort study on diet and cancer was started in the Netherlands among 62,573 women ages 55-69 years. Baseline information on diet and other risk factors was collected with a questionnaire. Cancer incidence was measured by record linkage with cancer registries and a pathology register. A case-cohort approach was used, in which the accumulated person time in the cohort was estimated by follow-up of a randomly selected subcohort (n = 1812). After 3.3 years of follow-up, 471 incident breast cancer cases were available for analysis. Questionnaire data for these cases and the 1716 female subcohort members without a history of cancer other than skin cancer were analyzed. In a multivariate analysis, controlling for traditional risk factors, the relative rates for breast cancer in increasing quintiles of energy-adjusted total fat intake were 1.00, 1.00, 1.34, 1.22, 1.08 (P-trend, 0.32). For saturated fat there was some evidence for a weak positive association when quintiles were used ...
TY - JOUR. T1 - Early cardiac changes following anthracycline chemotherapy in breast cancer: a prospective multi-centre study using advanced cardiac imaging and biochemical markers. AU - Grover, Suchi. AU - De Pasquale, Carmine. AU - Leong, Darryl. AU - Chakrabarty, Adhiraj. AU - Cheong, Kerry. AU - Kotasek, Dusan. AU - Joshi, Rohit. AU - Penhall, Amy. AU - Joerg, Lucas. AU - Joseph, Majo. AU - Koczwara, Bogda. AU - Selvanayagam, Joseph. PY - 2012. Y1 - 2012. M3 - Article. VL - 14. SP - 181. EP - 182. JO - Journal of Cardiovascular Magnetic Resonance. JF - Journal of Cardiovascular Magnetic Resonance. SN - 1097-6647. IS - S1. ER - ...
Atrial fibrillation (AF) after thoracic surgery is a continuing source of morbidity and mortality. The effect of postoperative AF on long-term survival however has not been studied. Our aim was to evaluate the impact of AF on early outcome and on survival | 5 years after pulmonary lobectomy for lung cancer. From 1996 to June 2009, 454 consecutive patients undergoing lobectomy for lung cancer were enrolled and followed-up until death or study end (October 2010). Patients with postoperative AF were identified; AF was investigated with reference to its predictors and to short- and long-term survival (| 5 years). Hospital mortality accounted for 7 patients (1.5%), while postoperative AF occurred in 45 (9.9%). Independent AF predictors were: preoperative paroxysmal AF (odds ratio [OR] 5.91; 95%CI 2.07 to 16.88), postoperative blood transfusion (OR 3.61; 95%CI 1.67 to 7.82) and postoperative fibro-bronchoscopy (OR 3.39; 95%CI 1.48 to 7.79). Patients with AF experienced higher hospital mortality (6.7% vs. 1.0%
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IMPORTANCE: Muscle pain, fatigue, and weakness are common adverse effects of statin medications and may decrease physical activity in older men. OBJECTIVE: Determine whether statin use is associated with physical activity, longitudinally and cross-sectionally. DESIGN, SETTING, AND PARTICIPANTS: Men participating in the Osteoporotic Fractures in Men Study, a multicenter prospective cohort study of community-living men age 65+, enrolled between March 2000-April 2002. EXPOSURE: Statin use as determined by an inventory of medications (taken within last 30 days). In cross-sectional analyses, statin use categories were: users and nonusers. In longitudinal analyses, categories were: prevalent users (baseline use and throughout study), new users (initiated use during the study) and nonusers (never used). MAIN OUTCOMES AND MEASURE: Self-reported physical activity at baseline and 2 follow-up visits using the Physical Activity Scale for the Elderly (PASE). At the third visit, an accelerometer measured ...
TY - JOUR. T1 - Association between dietary whole grain intake and risk of mortality. T2 - Two large prospective studies in US Men and Women. AU - Wu, Hongyu. AU - Flint, Alan J.. AU - Qi, Qibin. AU - Van Dam, Rob M.. AU - Sampson, Laura A.. AU - Rimm, Eric B.. AU - Holmes, Michelle D.. AU - Willett, Walter C.. AU - Hu, Frank B.. AU - Sun, Qi. PY - 2015/3/1. Y1 - 2015/3/1. N2 - IMPORTANCE: Higher intake of whole grains has been associated with a lower risk of major chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease (CVD), although limited prospective evidence exists regarding whole grains association with mortality. OBJECTIVE: To examine the association between dietary whole grain consumption and risk of mortality. DESIGN, SETTING, AND PARTICIPANTS: We investigated74 341 women from the Nurses Health Study (1984-2010) and 43 744 men from the Health Professionals Follow-Up Study (1986-2010), 2 large prospective cohort studies. All patients were free of CVD and cancer ...
OBJECTIVE To investigate the association of vitamin D status with all-cause mortality in a Norwegian population and the potential influences of existing chronic diseases on the association. DESIGN A population-based prospective cohort study. SETTING Nord-Trøndelag County, Norway. PARTICIPANTS A random sample (n=6613) of adults aged 20 years or older in a cohort. METHODS Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in blood samples collected at baseline (n=6377). Mortality was ascertained from the Norwegian National Registry. Cox regression models were applied to estimate the HRs with 95% CIs for all-cause mortality in association with serum 25(OH)D levels after adjustment for a wide spectrum of confounding factors as well as chronic diseases at baseline. RESULTS The median follow-up time was 18.5 years, during which 1539 subjects died. The HRs for all-cause mortality associated with the first quartile level of 25(OH)D (|34.5 nmol/L) as compared with the fourth quartile (≥58.1
Drug utilization evaluation (DUE) is an effective program to identify variability in drug use and to support interventions that will improve patient outcomes. The appropriate use of enoxaparin, a low molecular weight heparin (LMWH), which is widely used as curative or preventive treatment of thromboembolic disorders was assessed in the study. A prospective DUE was carried out at Masih Daneshvari teaching hospital. Criteria for the appropriate use of enoxaparin was used to evaluate prescription and administration patterns in this hospital. Enoxaparin utilization of 147 inpatients was reviewed. A total of 944 variables (70.92%) in the regimen, among all subjects, were rated as appropriate and 382 (28.70%) were rated as inappropriate for the conditions diagnosed. The results of this study showed that inappropriate dosing, administration and prescribing of enoxaparin is rather common in masih hospital. Educational programs and implementation of protocols may be needed in the teaching hospitals to control
Objective. To assess the outcome and adverse prognostic factors of bacterial arthritis BA. Methods. In a prospective community survey of BA, data were collected at the time of diagnosis and at a mean of 2 years later. A poor patient outcome was defined as death due to BA or severe overall functional deterioration. A poor joint outcome was...
© 2016 The Authors Introduction Wide local excision and adjuvant radiotherapy is the standard of care for early breast cancer. For large tumours, however, mastectomy is frequently recommended as conventional breast-conserving techniques often result in poor cosmetic outcomes. Therapeutic mammaplasty (TM) may extend the boundaries of breast-conserving surgery by combining breast reduction and mastopexy techniques with tumour excision, preserving a natural breast shape and avoiding the need for mastectomy. The prevalence of this operative option among surgeons in the UK and its success rate are unknown. The TeaM study is a multicentre prospective study that aims to investigate the practice and outcomes of TM. Methods and analysis Breast centres performing TM will be invited to participate through the research collaborative network and the professional associations. All patients undergoing TM between September 2016 and March 2017 will be included. Demographic, operative, oncological and complication data
This trial will compare the efficacy and tolerability of antithymocyte globulin [Thymoglobulin, rabbit antithymocyte globulin], mycophenolate mofetil
Results: In a cohort of 664 patients (median [interquartile range] observations: 3 [1 to 6]; data missing: BMI 2.5%, nutritional status 3.8%), BMI significantly increased from median [interquartile range] 24.4kg/m² [21.6kg/m² to 28kg/m²] in 2004 to 29.5kg/m² [24.4kg/m² to 35.4kg/m²] in 2019 (p,0.001). BMI categories significantly differed throughout the study period, with a decrease in underweight patients (31.6% to 18.1%), normal weight patients (26.7% to 16.3%) and overweight patients (20.2% to 18.6%); and increase in obese patients (21.5% to 47%) (χ² 142.9, df=12, p,0.001). The proportion of malnourished patients significantly decreased over time, from 14.5% to 9.3% (χ² 12.3, df=4, p=0.015 ...
TY - JOUR. T1 - The 2009 prospective multi-center epidemiologic survey of uveitis in Japan. AU - Ohguro, Nobuyuki. AU - Sonoda, Koh Hei. AU - Takeuchi, Masaru. AU - Matsumura, Miyo. AU - Mochizuki, Manabu. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Purpose To investigate etiologic data on intraocular inflammation in Japan collected in the 2009 epidemiologic survey of uveitis in Japan and assess the current state of etiology compared with that reported in a previous survey. Methods Thirty-six university hospitals participated in this prospective etiologic study. Patients who visited the outpatient uveitis clinic of each hospital for the first time between 1 June 2009 and 31 May 2010 were enrolled in the study. Uveitic diseases were diagnosed according to the guidelines when available or following commonly accepted diagnostic criteria. Results A total of 3,830 patients were enrolled in the survey and 2,556 cases of uveitis were identified, of which 1,274 cases were described as unclassified intraocular ...
BACKGROUND: Chronic, low-grade inflammation is an established risk factor for cardiovascular disease. The inflammatory impact of diet can be reflected by concentrations of inflammatory markers in the bloodstream and the inflammatory potential of diet can be estimated by the dietary inflammatory index (DII(TM)), which has been associated with cardiovascular disease risk in some previous studies. We aimed to examine the association between the DII and the risk of first myocardial infarction (MI) in a population-based study with long follow-up.. METHOD: We conducted a prospective case-control study of 1389 verified cases of first MI and 5555 matched controls nested within the population-based cohorts of the Northern Sweden Health and Disease Study (NSHDS), of which the largest is the ongoing Västerbotten Intervention Programme (VIP) with nearly 100 000 participants during the study period. Median follow-up from recruitment to MI diagnosis was 6.4 years (6.2 for men and 7.2 for women). DII scores ...
Although neck pain is common in young adulthood, studies on predictive factors for its onset and persistence are scarce. It is therefore important to identify possible risk factors among young adults so as to prevent the development of neck pain later in life. A prospective study was carried out in healthy undergraduate students. At baseline, a self-administered questionnaire and standardized physical examination were used to collect data on biopsychosocial factors. At 3, 6, 9, and 12 months thereafter, follow-up data were collected on the incidence of neck pain. Those who reported neck pain on ≥ 2 consecutive follow-ups were categorized as having persistent neck pain. Two regression models were built to analyze risk factors for the onset and persistence of neck pain. Among the recruited sample of 684 students, 46% reported the onset of neck pain between baseline and 1-year follow-up, of whom 33% reported persistent neck pain. The onset of neck pain was associated with computer screen position not
These results suggest that bupropion does not increase the rates of major malformation above baseline. The higher rates of spontaneous abortions are similar to other studies examining the safety of antidepressants during pregnancy.
RESULTS: By age 4 years, the cumulative incidence of stuttering onset was 11.2% (95% confidence interval [CI]: 9.7% to 12.8%). Higher maternal education (P = .004), male gender (P = .02), and twinning (P = .005) predicted stuttering onset. At outcome, stuttering children had stronger language (mean [SD]: 105.0 [13.0] vs 99.6 [14.6]; mean difference 5.5, 95% CI: 3.1 to 7.8; P , .001) and nonverbal cognition (mean [SD]: 106.5 [11.4] vs 103.9 [13.7], mean difference 2.6, 95% CI: 0.4 to 4.8; P = .02) and better health-related quality of life but were otherwise similar to their nonstuttering peers. Only 9 of 142 children (6.3%; 95% CI: 2.9% to 11.7%) recovered within 12 months of onset. ...
Rheumatoid arthritis (RA) is a progressive disease, often leading to disability. Because the disease course develops rapidly during the first years after diagnosis, more knowledge is needed about the early disease course to minimize later disability. This thesis describes the course of disability in early RA such as hand function, pain intensity, activity limitation and sick leave. In addition, this thesis compares disability between women and men and compares disability between RA patients and referents.. This thesis is primarily based on data from the 320 patients that were included in the multi-centre project in Sweden called Early interventions in rheumatoid arthritis (TIRA). A wide range of outcome variables was registered between 1996 and 2006 during regular follow-ups from time for diagnosis through the eight-year follow-up. Outcome regarding disease activity and disability of RA patients still remaining in TIRA at the three and five year follow-up respectively are used in this thesis. ...
As part of a project to examine health care ethics consultation in Canada, we surveyed individuals who were considered by themselves or others to play a significant role in health care ethics consultation. Since one goal ...
Risikoforebygging er en viktig del av alt helsearbeid, men det meste av evidens med hensyn på forebyggende helsearbeid er fremkommet ved studier utført på middelaldrende befolkningsgrupper med ulik ekstern validitet, med variabel oppfølgingstid, og med overvekt av menn. Modifiserbare risikofaktorer har potensielt ulik innvirkning i ulike aldersgrupper, i ulike faser av en lengre oppfølgingstid og med hensyn på forskjellige endepunkter (dødelighet: total og årsaksspesifikk). Målsetning: å studere forskjeller og likheter i effekten av livsstilsrelaterte risikofaktorer (særlig kroppsmasseindeks, fysisk aktivitet og lungefunksjon) på total dødelighet og årsaksspesifikk dødelighet som følge av hjerneslag og koronar hjertesykdom i ulike aldersgrupper av menn og kvinner i en generell norsk befolkning med 42 års oppfølgingstid. Materiale og metode: 6811 tilfeldig utvalgte menn og kvinner i alderen 20-79 og bosatt i Bergen i 1964 ble invitert til en utvidet helseundersøkelse etter ...
Background: Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims: To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods: Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results: Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95% confidence level [95% CI] ...
BA had a poor outcome in almost one-half of the patients. Patients who were older, had a preexisting joint disease, and/or had an infected joint containing synthetic material had the poorest prognosis.
Background: Large prospective epidemiologic studies are vital in determining disease etiology and forming national health policy. Yet, such studies do not exist in sub-Saharan Africa (SSA) notwithstanding the growing burden of chronic diseases. Objective: We explored the feasibility of establishing a large-scale multicountry prospective study at five sites in four sub-Saharan countries. Design: Based on country-specific considerations of feasibility, Nigeria enrolled health care professionals, South Africa and Tanzania enrolled teachers, and Uganda enrolled village residents at one rural and one periurban site each. All sites used a 6-month follow-up period but different approaches for data collection, namely standardized questionnaires filled out by participants or face-to-face interviews. Results: We enrolled 1415 participants from five sites (range 200489) with a median age of 41 years. Approximately half had access to clean-burning cooking fuel and 70% to piped drinking water, yet 92% had ...
Purpose: : To study the natural history and the major risk factors of ROP among the infants in Taiwan. Methods: : A prospective natural history study of ROP was performed for all premature infants from June 2010 to July 2011 at our childrens hospital. Patients were screened with birth weight (BW) less than 1500 grams or gestational age (GA) less than 32 weeks or selected infants with BW more than 1500 grams or GA more than 32 weeks with an unstable clinical course, including those requiring cardiorespiratory support and who are believed to be high risk by their pediatrician. The incidence of advanced ROP, the need for laser, Bevacizumab, or vitrectomy treatment was documented. The associated risk factors for the development of ROP were recorded. Results: : We enrolled 223 premature infants, and 98 infants (44%) developed ROP. The mean gestational age (GA) was 29.2 ± 3.0 (range 28-36) weeks and the mean BW was 1247.0 ± 441.5 (range 700-2705) grams. The incidence of ROP among BW more and less ...
Background: Physical activity (PA) is considered a cornerstone of diabetes mellitus management to prevent complications, but conclusive evidence is lacking. Methods: This prospective cohort study and meta-analysis of existing studies investigated the association between PA and mortality in individuals with diabetes. In the EPIC study (European Prospective Investigation Into Cancer and Nutrition), a cohort was defined of 5859 individuals with diabetes at baseline. Associations of leisure-time and total PA and walking with cardiovascular disease (CVD) and total mortality were studied using multivariable Cox proportional hazards regression models. Fixed-and random-effects meta-analyses of prospective studies published up to December 2010 were pooled with inverse variance weighting. Results: In the prospective analysis, total PA was associated with lower risk of CVD and total mortality. Compared with physically inactive persons, the lowest mortality risk was observed in moderately active persons: ...
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Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. ,300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = ...
Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The proportions of mediated effects (%) were estimated on the basis of differences in percent effect changes in conditional logistic regression models with and without additional adjustment for individual biomarkers. Greater adult weight gain (≥300 g/year vs. ,300 g/year) was associated with a higher risk of colon cancer (multivariable-adjusted relative risk = 1.54, 95% confidence interval: 1.07, 2.24) but not rectal cancer (relative risk = ...
BACKGROUND AND PURPOSE: The impact of smoking on prognosis after stroke is controversial. We aimed to assess the relationship between smoking status and stroke outcome after intravenous thrombolysis in a large cohort study by adjusting for potential confounders and incorporating recanalization rates. METHODS: In a prospective observational multicenter study, we analyzed baseline and outcome data of consecutive patients with acute ischemic stroke treated with intravenous thrombolysis. Using uni- and multivariable modeling, we assessed whether smoking was associated with favorable outcome (modified Rankin Scale score of 0-1) and mortality. In addition, we also measured the occurrence of symptomatic intracranial hemorrhage and recanalization of middle cerebral artery. Patients reporting active cigarette use were classified as smokers. RESULTS: Of 1865 patients, 19.8% were smokers (n=369). They were younger (mean 63.5 versus 71.3 years), less often women (56% versus 72.1%), and suffered less often ...
|jats:sec||jats:title|Introduction|/jats:title||jats:p|Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients.|/jats:p||/jats:sec||jats:sec||jats:title|Methods and analysis|/jats:title||jats:p|The SYNAPSE-ICU study is a large international, prospective, observational cohort study. From March 2018 to March 2019, all patients fulfilling the following inclusion criteria will be recruited: age >18 years; diagnosis of ABI due to primary haemorrhagic stroke (subarachnoid haemorrhage or intracranial haemorrhage) or