Propylthiouracil: Find the most comprehensive real-world treatment information on Propylthiouracil at PatientsLikeMe. 6 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Propylthiouracil.

A 36-year-old Chinese man presented to the Queen Mary Hospital in August 1999 with a 2-week history of jaundice due to propylthiouracil treatment for thyrotoxicosis. He had previously received carbimazole but had developed an urticarial skin rash after 2 weeks of treatment. The patient developed liver failure and fulminant pneumonitis shortly after hospital admission. Despite receiving treatment with broad-spectrum antibiotics and intravenous immunoglobulin, he died 11 days after the onset of the respiratory symptoms. Postmortem examination using electron microscopy showed typical glycogen bodies within the cytoplasm of the hepatocytes, which corresponded to eosinophilic cytoplasmic inclusion bodies visible under light microscopy. Immunohistochemical studies of the inclusion bodies were positive for carcinoembryonic antigen and albumin, and negative for fibrinogen, complement protein C3, immunoglobulins G, M, and A, α-fetoprotein, and α-1-antitrypsin. This is the first report of a patient who ...

Signs And Symptoms:Nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, edema, and pancytopenia. Agranulocytosis is the most serious effect. Rarely, exfoliative dermatitis, hepatitis, neuropathies, or CNS stimulation or depression may occur.. No information is available on the following: LD50; concentration of propylthiouracil in biologic fluids associated with toxicity and/or death; the amount of drug in a single dose usually associated with symptoms of overdosage; or the amount of propylthiouracil in a single dose likely to be life-threatening.. Treatment:To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the Physicians Desk Reference (PDR). In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient.. Protect the patients airway and ...

1.Duchenne and Becker muscular dystrophies are X-linked disorders caused by defects in muscle dystrophin. The mdx mouse is an animal model for Duchenne muscular dystrophy which has a point mutation in the dystrophin gene, resulting in little (, 3%) or no expression of dystrophin in muscle. Mdx mice show a characteristic pattern of muscle necrosis and regeneration. Muscles are normal until the third postnatal week when widespread necrosis commences. This is followed by muscle regeneration, with the persistence of centrally nucleated fibres.. 2.This work has examined the hypothesis that the onset of this muscle necrosis is associated with postnatal maturation of the thyroid endocrine system and that pharmacological inhibition of thyroid hormone synthesis delays the onset of muscle necrosis.. 3.Serum T4 and T3 concentrations of mice were found to rise immediately before the onset of muscle necrosis in the mdx mouse, and induction of hypothyroidism by treatment of animals with propylthiouracil was ...

Thyroid hormones (THs) play crucial roles in general and brain development. Even if the hypothyroidism is mild, it may alter brain function, resulting in irreversible behavioral alterations. Although various behavioral analyses have been conducted, the effects of propylthiouracil (PTU) treatment during in utero and postnatal periods on maternal behavior have not yet been studied. The present study examined in mice whether THs insufficiency during development induce behavioral changes. Pregnant C57BL/6j mice were divided into three groups, and each group was administered different dosages of PTU (0, 5, or 50 ppm) in drinking water during in utero and postnatal periods (from gestational day 14 to postnatal day 21). First, locomotor activity and cognitive function were assessed in the offspring at 10 weeks. Next, female offspring were mated with normal mice and they and their offspring were used to assess several aspects of maternal behavior (identifying first pup, returning all pups to nest, time spent

Effect of propylthiouracil (PTU)-induced hypothyroidism during the prepubertal period, at a dose of oneg per kg of the diet, on serum testosterone level and seminal characteristics of Fars indigenous chickens wasstudied. PTU was fed between 7th to 13th weeks of age and semen was collected at weekly intervals, starting at 21st week of age and continued for seven weeks. The effect of PTU treatment on serum testosterone level and body weight was significant (P|0.05). The effect of age on all parameters, including body weight, semen volume, sperm motility, percentage of live sperm, sperm concentration, total number of live sperm, and serum testosterone and thyroxine (T4) levels was also significant (P|0.01). The interaction effect of PTU treatment and age on semen volume, sperm motility, and percentage of live sperm was not significant (P|0.05); but it was significant for body weight, sperm concentration, total number of live sperm, and serum testosterone and T4 levels (P|0.01). At weeks 11 and 13 of age,

Individual differences in perception are ubiquitous within the chemical senses: taste, smell, and chemical somesthesis . A hypothesis of this fact states that polymorphisms in human sensory receptor genes could alter perception by coding for functionally distinct receptor types . We have previously …

The nature and tissue distribution of prolactin receptor (PRL-R) mRNA in both male and female rats was studied. A single mRNA species of 2.2kb was identified in the liver, kidney, adrenal, prostate, lactating mammary gland and ovary but not in the male lung, heart, skeletal muscle, thymus, adipose tissue or brain. There were distinct and contrasting sex differences in abundance of PRL-R mRNA in some tissues: liver (female,,male), kidney and adrenal (male ,,female). A mRNA species of 4kb was occasionally detected in the male adrenal and female liver. Given previous reports on the effects of thyroid status on PRL binding, the effects of thyroxine (T4), propylthiouracil (PTU) or combined treatment on PRL-R mRNA were assessed. In the male rat, PTU treatment markedly increased (three- to fourfold) PRL-R mRNA in the liver but decreased it (∼50%) in the kidney. These changes were reflected in similar changes in lactogenic binding activity. T4 or PTU treatment increased PRL-R mRNA in the prostate, ...

Thyrotoxicosis is associated with cardiac dysfunction; more commonly, left ventricular dysfunction. However, in recent years, there have been more cases reported on right ventricular dysfunction, often associated with pulmonary hypertension in patients with thyrotoxicosis. Three cases of thyrotoxicosis associated with right ventricular dysfunction were presented. A total of 25 other cases of thyrotoxicosis associated with right ventricular dysfunction published from 1994 to 2017 were reviewed along with the present 3 cases. The mean age was 45 years. Most (82%) of the cases were newly diagnosed thyrotoxicosis. There was a preponderance of female gender (71%) and Graves disease (86%) as the underlying aetiology. Common presenting features included dyspnoea, fatigue and ankle oedema. Atrial fibrillation was reported in 50% of the cases. The echocardiography for almost all cases revealed dilated right atrial and or ventricular chambers with elevated pulmonary artery pressure. The abnormal ...

Premetamorphic tadpoles of Xenopus laevis reared in water containing 0·01% propylthiouracil are developmentally retarded and metamorphosis is prevented. When uncrowded, they continue to grow to a giant size. Moderate crowding leads to a slower rate of growth. Thus morphologically premetamorphic tadpoles were produced with lens diameters appropriate to either normal premetamorphic, climactic or post-metamorphic animals. The lens crystallins of such tadpoles have been separated by immunoelectrophoresis and polyacrylamide gel electrophoresis. The crystallin pattern was correlated with lens diameter rather than with body stage. Giant retarded larvae possessed crystallin patterns identical to those of normal adults. The thyroid antagonist propylthiouracil is therefore unable to prevent the lens crystallin transition, the beginning of which is normally temporally correlated with metamorphosis.. ...

OBJECTIVE During the critical period of brain development, insufficiency of thyroid hormone results in severe mental retardation and learning deficit. This study was designed to investigate the effects of hypothyroidism on apoptosis and the expression of Bcl-2 and Bax gene in the developing rat hippocampus neurons and to explore the mechanism of brain development regulated by thyroid hormone. METHOD Hypothyroidism was induced by administration of propylthiouracil (PTU, 50 mg/d) solution to the dams from gestational day 15 by gavage. Pups from both hypothyroid and control groups were harvested at postnatal day 1 (P1), P5, P10 and P15, respectively. Blood samples were collected at the time of death for the determination of thyroid hormone. Serum free tri-iodothyronine (FT(3)) and free thyroxine (FT(4)) were measured by using chemoluminescence. Hippocampus collected from the control and hypothyroid pups were examined under light and transmissional electron microscopy. Measurement of DNA fragmentation was

The most commonly used antithyroid drugs are Propylthiouracil (P.T.U.) and Tapazole (Methimazole). These drugs act to prevent the thyroid gland from manufacturing thyroid hormone, and thus the symptoms of hyperthyroidism will gradually subside.. You will probably begin to feel better within two weeks, you will feel a difference by six weeks, and feel well in 10-14 weeks. You will probably take the medication for 6-12 months. Your doctor will check at six months, nine months and twelve months approximately, to see if P.T.U. is still needed. If your thyroid gland now functions normally, your family doctor will still check you periodically to be sure that your thyroid hormone level (T4) remains within the normal range or just above (normal T4 range - 50-165nmol/L). Most patients feel better with a T4 level in the upper half of normal (110-165nmol/L).. If taking antithyroid drugs, P.T.U. or Tapazole, and you develop a rash, itching, hives, joint pains, a fever or sore throat, stop taking the drug ...

The most commonly used antithyroid drugs are Propylthiouracil (P.T.U.) and Tapazole (Methimazole). These drugs act to prevent the thyroid gland from manufacturing thyroid hormone, and thus the symptoms of hyperthyroidism will gradually subside.. You will probably begin to feel better within two weeks, you will feel a difference by six weeks, and feel well in 10-14 weeks. You will probably take the medication for 6-12 months. Your doctor will check at six months, nine months and twelve months approximately, to see if P.T.U. is still needed. If your thyroid gland now functions normally, your family doctor will still check you periodically to be sure that your thyroid hormone level (T4) remains within the normal range or just above (normal T4 range - 50-165nmol/L). Most patients feel better with a T4 level in the upper half of normal (110-165nmol/L).. If taking antithyroid drugs, P.T.U. or Tapazole, and you develop a rash, itching, hives, joint pains, a fever or sore throat, stop taking the drug ...

Almiro de Almeida Vasconcelos Neto, Maria Isabel Pereira Vianna, Luciana Maria Pereira Ramalho, Gardênia Matos Paraguassu, Dario Augusto Oliveira Miranda This study aimed at assessing bone repair of critical-size defects by comparing normal animals with hypothyroid animals, with or without bone graft (Bio-Oss® Geistlich Pharma AG, Wolhusen, Switzerland) at two times of evaluation (30 and 60 days). Forty-two Wistar rats were used and divided into two major groups, namely: Group 1: Euthyroid, without graft, 30 days (G1E30); euthyroid, without graft, 60 days (G1E60); hypothyroid, without graft, 30 days (G1H30) and hypothyroid, without graft 60 days (G1H60). Group 2: Euthyroid, grafted, 30 days (G2E30); euthyroid, grafted, 60 days (G2E60); hypothyroid, grafted, 30 days (G2H30) and hypothyroid, grafted, 60 days (G2H60). The animals were induced to hypothyroidism by propylthiouracil (PTU) diluted with drinking water. Critical-size defects were created by trephine burs in the rats calvarium. ...

We present a previously undocumented complication of carbimazole treatment occurring in a 28 year old woman with Graves disease. Four months after starting carbimazole (40 mg, dropping to 20 mg daily after six weeks) she developed left sided otalgia and presented with high pitched tinnitus. An audiogram showed a unilateral 25 dB high frequency loss which could not be accounted for by family or occupational history. Brain stem audiometry showed no evidence of an acoustic neuroma; the only abnormal result was a raised titre of antibodies to DNA (106 IU, normal range 0-50). Carbimazole hypersensitivity was diagnosed, and she started taking propylthiouracil instead (100 mg twice daily). Four months later the hearing loss had subjectively improved and an audiogram showed that her hearing was within normal limits, although the tinnitus persisted. The DNA antibody titre had dropped substantially to 54 IU, and she had not developed any further symptoms of hypersensitivity.. Acute ototoxicity has been ...

I developed Graves Disease four months postpartum. After one year on propylthiouracil, I learned that omega-3 fatty acids may reduce inflammation associated with certain autoimmune disorders, although no investigations for thyroiditis have been repo

Vegetable Intake in College-Aged Adults Is Explained by Oral Sensory Phenotypes and TAS2R38 Genotype. Chemosens Percept. 2010 Dec 1;3(3-4):137-148. Duffy VB, et al. http://www.ncbi.nlm.nih.gov/pubmed/21157576 Taste and oral sensations vary in humans. Some of this variation has a genetic basis, and two commonly measured phenotypes are the bitterness of propylthiouracil (PROP) and the number of fungiform…

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Casas, C B., Induction of hepatomas by thiouracil in inbred strains of mice. (1963). Subject Strain Bibliography 1963. 199 ...

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Drowsiness, nausea, and headache are some of the possible side effects of PTU. This eMedTV Web page lists other possible problems with this drug and describes which ones are serious and should be reported to a healthcare provider.

2002 (English)In: Journal of Radioanalytical and Nuclear Chemistry, ISSN 0236-5731, E-ISSN 1588-2780, Vol. 251, 409-441 p.Article in journal (Refereed) Published ...

Unless otherwise noted, only ONE each of these items was created and used for filming! You are guaranteed to possess the actual prop seen on screen!. Pricing listed for each prop is for U.S. customers only… and shipping is free! If you wish to purchase a prop and have it shipped outside of the United States, please email [email protected], specify the prop(s) you wish to buy and to where youd like them shipped. You will receive a quote for non-U.S. shipping charges as well as special ordering instructions.. Please allow 2 to 3 weeks for delivery.. ...

Prop 65 is a list of chemicals known to the State of California to cause cancer, birth defects, or other reproductive harm. This list, which must be updated at least once a year, has grown to include over 900 chemicals since it was first published in 1987. Prop 65 requires businesses to provide Californians with a clear and reasonable warning about chemicals in the products they purchase, in their home or workplace, or that are released into the environment. Due to the amount of products offered that may contain small amounts of listed chemicals as ingredients, all of Classic Transmission Solutions are categorized as items that have a Prop 65 warning. Please check the following link to review the list of chemicals Prop 65 (www.oehha.ca.gov/proposition-65). Please email [email protected] if you have any questions or concerns regarding the policy.. ...

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An antithyroid agent is a hormone antagonist acting upon thyroid hormones. The main antithyroid drugs are carbimazole (in the UK), methimazole (in the US), and propylthiouracil/PTU. A less common antithyroid agent is potassium perchlorate. In Graves disease, treatment with antithyroid medications must be given for six months to two years, in order to be effective. Even then, upon cessation of the drugs, the hyperthyroid state may recur. Side effects of the antithyroid medications include a potentially fatal reduction in the level of white blood cells. A randomized control trial testing single dose treatment for Graves found methimazole achieved euthyroid state more effectively after 12 weeks than did propylthyouracil (77.1% on methimazole 15 mg vs 19.4% in the propylthiouracil 150 mg groups). But generally both drugs are considered equivalent. A study has shown no difference in outcome for adding thyroxine to antithyroid medication and continuing thyroxine versus placebo after antithyroid ...

The primary goals of treatment for hyperthyroidism are to eliminate excess thyroid hormone and minimize the long-term consequences.9 Treatments include radio-active iodine, antithyroid medications (propylthiouracil [PTU], methimazole [MMI]), and surgery.2,8-10 Beta-blockers are sometimes added to provide symptomatic relief.9,13,15. Radioactive Iodine Therapy (RIT): The usual dose for RIT ranges from 5 to 15 mCi of 131I. In general, higher dosages are required for patients who have large goiters or low radioiodine uptake, or who have been pretreated with antithyroid drugs.15,16. Because the thyroid needs iodine to produce hormones, the radioiodine goes into the thyroid cells and, over time, overactive thyroid cells are destroyed. The thyroid gland shrinks, and in several weeks to months, hyperthyroid symptoms gradually diminish.16 RIT may increase the risk of new or worsened symptoms of Graves ophthalmopathy. This adverse effect is usually mild and temporary, but the therapy may not be utilized ...

Hyperthyroidism per se can cause mild elevation in liver enzymes which normalizes with treatment. Thyrostatic medications (carbimazole or propylthiouracil) as first line therapy to treat hyperthyroidism can rarely cause potentially fatal hepatotoxicity.. We report a patient who developed cholestatic jaundice after carbimazole therapy.. Case report: A 32-year-old woman presented with weight loss, heat intolerance, palpitations and sore eyes.. Physical examination revealed tachycardia, exophthalmos left eye, diffuse goitre and audible thyroid bruit. TSH ,0.05 miu/l, Free T4 62.7 pmol/l, T3 12.0 nmol/l and thyroid peroxidise antibodies 1186 iu/l. Graves thyrotoxicosis was diagnosed and carbimazole 40 mg a day was initiated.. Within 3 months, she developed excessive itchiness. Liver function test showed ALT 120 IU/l (,40), ALP 750 iu/l (70 300). Drug induced hepatitis was suspected hence carbimazole was discontinued and propylthiouracil was started. Within a week, skin itchiness settled. Liver ...

If you are taking carbimazole or propylthiouracil or any other antithyroid medicationand develop a sore throat mouth ulceration or fever flulike illness you must STOP the antithyroid medication and have an urgent full blood count FBC performed tomeasure white cell countdifferential along with testing for COVID19

Taking antithyroid drugs (ATDs) during the first trimester of pregnancy is associated with an increased risk for birth defects, particularly for women receiving prescriptions for methimazole (MMI) or both MMI and propylthiouracil (PTU). The findings are published in Annals of Internal Medicine.

The bitter taste receptor gene [[TAS2R38]] has been associated with the ability to taste PROP,ref name=Duffy 2004,{{cite journal ,doi=10.1097/01.ALC.0000145789.55183.D4 ,title=Bitter Receptor Gene (TAS2R38), 6-n-Propylthiouracil (PROP) Bitterness and Alcohol Intake ,year=2004 ,last1=Duffy ,first1=Valerie B. ,last2=Davidson ,first2=Andrew C. ,last3=Kidd ,first3=Judith R. ,last4=Kidd ,first4=Kenneth K. ,last5=Speed ,first5=William C. ,last6=Pakstis ,first6=Andrew J. ,last7=Reed ,first7=Danielle R. ,last8=Snyder ,first8=Derek J. ,last9=Bartoshuk ,first9=Linda M. ,journal=Alcoholism: Clinical & Experimental Research ,volume=28 ,issue=11 ,pages=1629-37 ,pmid=15547448 ,pmc=1397913}},/ref, and PTC;,ref,{{cite journal ,doi=10.1016/j.cub.2005.01.047 ,title=The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception ,year=2005 ,last1=Bufe ,first1=Bernd ,last2=Breslin ,first2=Paul A.S. ,last3=Kuhn ,first3=Christina ,last4=Reed ,first4=Danielle R. ...

Our ability to perceive sweetness varies a lot and is partly controlled by our genes. A recent twin study found genetics accounts for about a third of the variation in sweet taste perception of sugar and low-calorie sweeteners. Researchers have identified specific gene variants in the receptors that detect sweetness: TAS1R2 and TAS1R3.. There is also high variation in the detection of bitterness. However, the story is more complicated than sweet taste, as we have 25 receptors that detect different bitter molecules. Bitter receptors evolved to detect and stop us from eating harmful toxins. Thats why bitterness is not widely liked.. One of these bitter taste receptors (TAS2R38) controls the ability to detect a bitter compound called PROP (propylthiouracil). Based on the ability to detect PROP, people can be split into two groups: tasters or non-tasters. Tasters often dislike bitter green vegetables, such as broccoli and Brussels sprouts.. PROP status has also been used as a marker of food ...

Seventy-five non-smoking volunteers (28 men and 47 women) were recruited for the study. Participants between 20-30 years were eligible for the study. Thresholds for the 4 basic tastes were evaluated in all subjects in order to rule out any gustatory impairment. The volunteers showed no variation of body weight , 5 kg over the last 3 mo. They were not following a prescribed diet or using medications that might interfere with taste perception; none had food allergies. They were assessed for cognitive eating behaviours using the Three-Factor Eating ...

Most commonly caused by Graves disease, most-often in women 20-40 years of age (0.2% incidence in parturients). Elective procedures should be deferred until the disease is well-controlled (B-blockers [inhibit peripheral conversion of T4 to T3 in addition to controlling heart rate, goal rate is 85 bpm], antithyroids [methimazole and propylthiouracil, both of which block synthesis of new thyroid hormones but do not affect release of existing hormone. Methimazole works more quickly and has less side effects], +/- iodine [blocks the actual release of thyroid hormone]).. Preoperative evaluation should always include a neck exam, and in some cases, a CT scan.. Hyperthyroid patients can be chronically hypovolemic and vasodilated and are prone to an exaggerated hypotensive response during induction of anesthesia, thus pay attention to volume status preoperatively.. Some authors advocate for a thiopental induction, as it has antithyroid properties at high doses, but the advantage is theoretical and has ...

5766 Propylthiouracil [PTU] induced decline in blood free thyroxine[fT4] correlates with survival in recurrent high grade glioma. Aim :- to prolong survival in recurrent glioma patients by PTU induced thyroid hormone depletion Rationale :- Recurrent glioma patients are generally unresponsive to conventional chemotherapy and have very short survival .The thyroid hormones free thyroxine[fT4] and tri-iodothyronine[T3] physiologically modulate metabolism but also are mitogenic in glioma and other neoplastic cell lines via interaction with cell membrane α1Vβ3 integrin, and upregulation of EGFR, IGF-1,II, Cyclins D, E and cdk2. Hormone depletion results in cell cycle arrest and decreased proliferation. We attempted to improve survival in recurrent high grade glioma patients by inducing thyroid suppression with PTU in patients who also received high dose tamoxifen for its reported cytostatic effect in glioma. . Methods and Patients :- 36 patients with WHO grade 4 recurrent glioma received ...

Fetal goiter is a rare potential cause of airway obstruction and neonatal hypoxic-ischemic brain injury or death.1 MR imaging evaluation of the enlarged gland and airway can provide information crucial to perinatal management. Because the neuroradiologist may be required to apply expertise in MR imaging and in head and neck anatomy to these cases, we describe imaging findings in fetal goiter and discuss fetal MR imaging protocol optimization.. Screening sonography of the 33-week fetus of a woman with Graves disease on propylthiouracil (PTU) therapy revealed a homogeneous 5.3-cm bilobed anterior neck mass suspicious for goiter and mild polyhydramnios. The distal femoral ossification center was not seen, and fetal heart rate was normal. The PTU dose was reduced, and subsequent fetal MR imaging (Fig 1) at 34.5 weeks gestation demonstrated a T1 hyperintense and T2 low-intensity bilobed anterior neck mass consistent with goiter, slightly decreased in size. The airway was poorly visualized at the ...

Sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) is an inherited trait. Although some people find PROP to be extremely bitter, others cannot distinguish PROP solutions from plain water. In a series of studies, greater PROP sensitivity was linked with lower acceptability of other bitter compounds and with lower reported liking for some bitter foods. Women, identified as super-tasters of PROP, had lower acceptance scores for grapefruit juice, green tea, Brussels sprouts, and some soy products. Many of these foods contain bitter phytochemicals with reputed cancer-protective activity. These include flavonoids in citrus fruit, polyphenols in green tea and red wine, glucosinolates in cruciferous vegetables, and isoflavones in soy products. Consumer acceptance of these plant-based foods may depend critically on inherited taste factors. This review examines the role of genetic taste markers in determining taste preferences and food choices.. ...

Description of disease Drug, antithyroid. Treatment Drug, antithyroid. Symptoms and causes Drug, antithyroid Prophylaxis Drug, antithyroid

Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dyslipidemia is characterized by abnormalities in blood lipid profiles. This study aims to determine the effect of ethanol extract of papaya seeds (Carica papaya L.) on lipid profile parameters, namely total cholesterol, triglycerides, LDL (Low Density Lipoprotein), and HDL (High Density Lipoprotein) dyslipidemia in rats This study examination of characteristic, . phytochemical screening of simplicia and ethanol extract of papaya seeds, and testing of ethanol extract of papaya seeds on lipid profile. This study uses an experimental method with post-test only control group design with 20 Wistar rats were then divided randomly into 5 groups. Ethanol extract of papaya seeds administered orally at a dose of 200 mg/kg bw and 400 mg/kg bw. Simvastatin dose of 0.9 mg/kg bw administered orally as a positive control. Quail egg yolk 1% body weight and propylthiouracil dose of 9 mg/kg bw administered orally as a control for comparison. ...

King, D W.; Bock, F G.; and Moore, G E., Dinitrophenol inhibition of pituitary adenoma formation in mice fed propylthiouracil. (1963). Subject Strain Bibliography 1963. 586 ...

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TY - CONF. T1 - Idealized and realistic large-eddy simulations of optical turbulence (Cn2). AU - Basu, Sukanta. AU - Kulikov, Victor. PY - 2017/1/1. Y1 - 2017/1/1. N2 - We will first discuss the development of Cn2 parameterizations based on tuning-free large-eddy simulations (LES). Then, we will demonstrate the strength of a coupled mesoscale-LES modeling framework in capturing Cn2 evolutions from recent field campaigns.. AB - We will first discuss the development of Cn2 parameterizations based on tuning-free large-eddy simulations (LES). Then, we will demonstrate the strength of a coupled mesoscale-LES modeling framework in capturing Cn2 evolutions from recent field campaigns.. UR - http://www.scopus.com/inward/record.url?scp=85026312443&partnerID=8YFLogxK. U2 - 10.1364/PCAOP.2017.PTu3D.1. DO - 10.1364/PCAOP.2017.PTu3D.1. M3 - Abstract. AN - SCOPUS:85026312443. T2 - Propagation Through and Characterization of Atmospheric and Oceanic Phenomena, pcAOP 2017. Y2 - 26 June 2017 through 29 June ...

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