As stated above, you can use the survreg function. A note though: this is not strictly a Cox PH model, but rather location-scale models. Using the default log-transformation, this is the aft model. In the case of the exponential distribution, the proportional hazards and aft model are equivalent, so if distribution is set to exponential, this is a proportional hazards model with an exponential baseline. Likewise, if a baseline Weibull distribution aft model is used, the parameter estimates are just a linear transformation of those used in the proportional hazards model with Weibull baseline distribution. But in general, survreg does not fit a Cox PH model. If a semi-parametric model is desired, as found implemented in intcox, a word of caution: there are several issues with the current version of intcox (algorithm typically prematurely terminates significantly far from the MLE, fails outright with uncensored observations, no standard errors automatically presented). A new alternative that you ...
Background: Physical activity (PA) is considered a cornerstone of diabetes mellitus management to prevent complications, but conclusive evidence is lacking. Methods: This prospective cohort study and meta-analysis of existing studies investigated the association between PA and mortality in individuals with diabetes. In the EPIC study (European Prospective Investigation Into Cancer and Nutrition), a cohort was defined of 5859 individuals with diabetes at baseline. Associations of leisure-time and total PA and walking with cardiovascular disease (CVD) and total mortality were studied using multivariable Cox proportional hazards regression models. Fixed-and random-effects meta-analyses of prospective studies published up to December 2010 were pooled with inverse variance weighting. Results: In the prospective analysis, total PA was associated with lower risk of CVD and total mortality. Compared with physically inactive persons, the lowest mortality risk was observed in moderately active persons: ...
We explore the benefits of applying a new proportional hazard model to analyze survival of breast cancer patients. As a parametric model, the hypertabastic survival model offers a closer fit to experimental data than Cox regression, and furthermore provides explicit survival and hazard functions which can be used as additional tools in the survival analysis. In addition, one of our main concerns is utilization of multiple gene expression variables. Our analysis treats the important issue of interaction of different gene signatures in the survival analysis. The hypertabastic proportional hazards model was applied in survival analysis of breast cancer patients. This model was compared, using statistical measures of goodness of fit, with models based on the semi-parametric Cox proportional hazards model and the parametric log-logistic and Weibull models. The explicit functions for hazard and survival were then used to analyze the dynamic behavior of hazard and survival functions. The hypertabastic model
BackgroundRadiotherapy is an effective treatment for intermediate/high-risk locally-advanced prostate cancer, however, |30% of patients relapse within five years. Clinicopathological parameters currently fail to identify patients prone to systemic relapse and those whom treatment intensification may be beneficial. The purpose of this study was to independently validate the performance of a 70-gene Metastatic Assay in a cohort of diagnostic biopsies from patients treated with radical radiotherapy and androgen deprivation therapy (ADT).Patients & MethodsA bridging cohort of prostate cancer diagnostic biopsy specimens was profiled to enable optimization of the Metastatic Assay threshold prior to further independent clinical validation in a cohort of diagnostic biopsies from patients treated with radical radiotherapy and ADT. Multivariable Cox proportional hazard regression analysis was used to assess assay performance in predicting biochemical failure-free survival (BFFS) and metastasis-free survival (MFS)
This course discusses survival analysis concepts with an emphasis on health care problems. The course focuses on the Cox proportional hazards model, not the parametric models, and is not designed for predictive modelers.
Background: As the aging issue and increased elderly esophageal cancer (EC) patients, we sought to study the clinical characteristics, treatment modality and outcomes of EC patients 70 years or older compared with those younger than 70 years old.. Methods: The national surveillance, epidemiology, and end results (SEER) database for the period from 1973 to 2013 was analyzed. The patient and treatment characteristics were compared between the age groups. Multivariate Cox proportional hazard regression analyses were also performed to identify independent prognostic factors. Propensity-score matching analyses (PSA) regarding survival after different treatments were also performed in locoregional EC.. Results: Compared with the younger group, patients 70 years or older were characterized by having a higher proportion of patients with female gender, white race, localized disease, non-adenocarcinoma and without any treatment, as well as inferior overall survival (OS) [hazard ratio (HR), 1.324] and ...
Background: Periodontal disease, a common disorder of the tissue surrounding and supporting the teeth, is a major cause of tooth loss in adults. Periodontal infection by oral microorganisms may have systemic effects and has been associated with several types of cancer. However, its association with liver cancer has only been examined in two prospective studies, both of which had very small number of liver cancer cases (n , 20).. Methods: We examined the association of tooth loss, as a proxy measure of periodontal infection, with primary liver cancer incidence and chronic liver disease mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study, a prospective cohort of male Finnish smokers (n = 29,096). Number of permanent teeth lost was assessed at study baseline (1985-1988). We used Cox proportional hazards models to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). As a sensitivity analysis, we conducted a nested case-control study to ...
The profiles of patients with fulminant hepatic failure (FHF) from developing countries have not been reported earlier. The current study was conducted prospectively, at a single tertiary care center in India, to document the demographic and clinical characteristics, natural course, and causative profile of patients with FHF as well as to define simple prognostic markers in these patients. Four hundred twenty-three consecutive patients with FHF admitted from January 1987 to June 1993 were included in the study. Each patients serum was tested for various hepatotropic viruses. Univariate Coxs regression for 28 variables, multivariate Coxs proportional hazard regression, stepwise logistic regression, and Kaplan-Meier survival analysis were done to identify independent predictors of outcome at admission. All patients presented with encephalopathy within 4 weeks of onset of symptoms. Hepatotropic viruses were the likely cause in most of these patients. Hepatitis A (HAV), hepatitis B (HBV), ...
OBJECTIVE: Evaluate the incidence and predictors of HIV acquisition from outside partners in serodiscordant couples. METHODS: Demographic, behavioral, and clinical exposures were measured quarterly in a cohort of serodiscordant cohabiting couples in Zambia from 1995 to 2012 (n = 3049). Genetic analysis classified incident infections as those acquired from the study partner (linked) or acquired from an outside partner (unlinked). Factors associated with time to unlinked HIV infection were evaluated using multivariable Cox proportional hazards regression stratified by sex. RESULTS: There were 100 unlinked infections in couples followed for a median of 806 days. Forty-five infections occurred in women [1.85/100 couple-years; 95% confidence interval (CI): 1.35 to 2.47]. Risk of female unlinked infection (vs. nonseroconverting females) was associated with reporting being drunk weekly/daily vs. moderate/nondrinkers at baseline [adjusted hazard ratio (aHR) = 5.44; 95% CI: 1.03 to 28.73], genital ulcers ...
Methods This meta-analysis included data from individual patients with RA randomized to double-blind treatment with combination therapy of ADA+MTX vs. MTX monotherapy in Phase II/III clinical trials (ARMADA, DE019, PREMIER, and OPTIMA [first double-blind period]); the maximum double-blind trial duration was 2 years. All patients who received at least one dose of study drugs were included. The primary outcome was the time from baseline to a MACE, a composite of nonfatal myocardial infarction (MI), nonfatal stroke, and CV death. These component events were also studied separately. Events were adjudicated by a blinded external panel of 2 cardiologists and 1 neurologist. Times to events were compared between the ADA+MTX and MTX arms using Kaplan-Meier estimates of the cumulative risk and Cox proportional-hazards models stratified by trial. The sequential Holm procedure was used to account for testing of each MACE component. Multivariable Cox models were also applied, with stratification by trial and ...
Thirteen patients (7%) with SVR and 100 patients (30%) without SVR died after prolonged follow-up of our cohort, which was more than 4 times the number of deaths registered during the first data collection (n = 2 among patients with SVR and n = 24 among patients without SVR).11 There was a significant difference in the cumulative 10-year mortality rate between patients with SVR (8.9%; 95% CI, 3.3%-14.5%) and without SVR (26.0%; 95% CI, 20.2%-28.4%; P < .001) (Figure). Cox proportional hazards regression analysis showed that SVR was associated with a statistically significant reduction in the hazard of overall death (adjusted hazard ratio [HR], 0.26; 95% CI, 0.14-0.49; P < .001) (Table 3, model 1). Other baseline factors significantly associated with all-cause mortality in multivariate analysis were older age, HCV genotype 3 infection, higher Ishak fibrosis score, presence of diabetes, and a history of severe alcohol use. Patients with HCV genotype 3 infection were younger (median [IQR] age, 44 ...
Background NGR-hTNF (asn-gly-arg-human tumor necrosis factor) induces systemic release of cytokines and intratumoral infiltration of effector T cells. Intravenous infusion of NGR-hTNF is characterized by onset of IRR, mostly consisting of transient grade 1-2 chills. Incidence, predictors of development, and relationships with outcome of IRR were assessed across 5 phase 2 single-arm trials of NGR-hTNF.. Methods 205 patients (pts) with solid tumors received NGR-hTNF 0.8 µg/m2 every 3 weeks (q3w) given either alone in colon cancer (n = 45), liver cancer (n = 40), and mesothelioma (n = 55), or with doxorubicin in small-cell lung cancer (n = 28) and ovarian cancer (n = 37). Tumor assessment by RECIST was done q6w until progressive disease (PD). Logistic and Cox proportional-hazards regression models were used to analyze associations between IRR and outcome, in terms of response rate (RR, complete and partial response), disease control rate (DCR, rate of pts without PD at 6 weeks), and ...
Potential effect of various immunocompetent cells from ascitic fluid on overall survival calculated using Cox proportional-hazards regression model
在先前的三篇文章已經有介紹存活分析(Survival analysis)的使用時機、如何繪製存活曲線圖(Kaplan-Meier curve),以及如何比較「組別」之間的存活曲線是否有顯著差異(Log
The nested case-control (NCC) design is widely used in epidemiologic studies as a cost-effective subcohort sampling method to study the association between a disease and its potential risk factors. NCC data are commonly analyzed using Thomas partial likelihood approach under the Cox proportional hazards model assumption. However, the linear modeling form in the Cox model may be insufficient for practical applications, especially when there are a large number of risk factors under investigation. In this paper, we consider a partially linear single index proportional hazards model, which includes a linear component for covariates of interest to yield easily interpretable results and a nonparametric single index component to adjust for multiple confounders effectively. We propose to approximate the nonparametric single index function by polynomial splines and estimate the parameters of interest using an iterative algorithm based on the partial likelihood. Asymptotic properties of the resulting ...
Supplementary MaterialsFigure S1: Immunological properties from the materials presented in desk S1. (1.2M) GUID:?47640B6B-0287-4C90-B672-118435E94B5F Amount S2: TNF- creation by individual macrophage-like THP-1 cells subsequent incubation with amphiphiles 1C21. TC supernatants had been supervised for cytokine creation via ELISA, and email address details are reported in pg/mL. All scholarly research were performed in two unbiased natural… Continue reading Supplementary MaterialsFigure S1: Immunological properties from the materials presented in desk. ...
Reliable biomarkers of apatinib response in gastric cancer (GC) are lacking. We investigated the association between early presence of common adverse events (AEs) and clinical outcomes in metastatic GC patients. We conducted a retrospective cohort study using data on 269 apatinib-treated GC patients in two clinical trials. AEs were assessed at baseline until 28 days after the last dose of apatinib. Clinical outcomes were compared between patients with and without hypertension (HTN), proteinuria, or hand and foot syndrome (HFS) in the first 4 weeks. Time-to-event variables were assessed using Kaplan-Meier methods and Cox proportional hazard regression models. Binary endpoints were assessed using logistic regression models. Landmark analyses were performed as sensitivity analyses. Predictive model was analyzed, and risk scores were calculated to predict overall survival. Presence of AEs in the first 4 weeks was associated with prolonged median overall survival (169 vs. 103 days, log-rank p = 0.0039;
Synonyms for Hazard function in Free Thesaurus. Antonyms for Hazard function. 108 synonyms for function: purpose, business, job, concern, use, part, office, charge, role, post, operation, situation, activity, exercise, responsibility.... What are synonyms for Hazard function?
6. Stats: More than 90% censored values (April 22, 2005). Someone asked me about running a Cox proportional hazards regression model when over 90% of the observations were censored. That means (if the outcome of interest was death), that your research subjects did not cooperate and die fast enough. Good news from the patients perspective, but bad news for the statistician. 90% censored observations is not a problem, though, as long as your sample size is adequate. As a rough rule of thumb, you need to have 25 to 50 events (uncensored observations) in each treatment group to have reasonable precision. Of course, if you have fewer events, the model is still valid, but your confidence intervals may end up being wider than youd really like.. 5. Stats: Stratified Cox regression models (March 22, 2005). Someone sent me an email asking about a Cox regression model that included a strata for clinics. Whats the best way to handle strata? Thats a tricky question to answer. The first question you might ...
Cancer, Breast, Breast Cancer, Mortality, Recurrence, Risk, Diagnosis, Women, Association, Survivors, Survival, Associations, Cox Proportional Hazards Models, Hazards Models, Prognosis, Proportional Hazards Models, Health, Confidence Intervals, Recurrences, Physical Activity
Create the simplest test data set # test1 ,- list(time= c(4, 3,1,1,2,2,3), status=c(1,NA,1,0,1,1,0), x= c(0, 2,1,1,1,0,0), sex= c(0, 0,0,0,1,1,1)) coxph( Surv(time, status) ~ x + strata(sex), test1) #stratified model # # Create a simple data set for a time-dependent model # test2 ,- list(start=c(1, 2, 5, 2, 1, 7, 3, 4, 8, 8), stop =c(2, 3, 6, 7, 8, 9, 9, 9,14,17), event=c(1, 1, 1, 1, 1, 1, 1, 0, 0, 0), x =c(1, 0, 0, 1, 0, 1, 1, 1, 0, 0) ) summary( coxph( Surv(start, stop, event) ~ x, test2 ...
By adapting survival analysis on the staying at home of qualified recipients for long-term care, this paper attempts to empirically clarify what factors contribute to staying at home as long as possible. Using the National Health Insurance Services Long-Term Care Qualification Longitudinal Survey (2008-2015), this paper analyzed the factors contributing to the initial benefit selection and at-home survival rate. The results of the factor analysis showed that the probability of choosing home care was higher for males, lower age group, having family caregivers. On the other hand, in the case of dementia, the probability of choosing institutional care was high. As a result of the life table analysis, it was found that 13.1% of the initial home care users changed to institutional care, and about 71% of the moves take place between 2 and 4 years. The Cox proportional hazards regression model analysis showed that the likelihood of withdrawal from home care was higher: for women, for older, for those ...
By adapting survival analysis on the staying at home of qualified recipients for long-term care, this paper attempts to empirically clarify what factors contribute to staying at home as long as possible. Using the National Health Insurance Services Long-Term Care Qualification Longitudinal Survey (2008-2015), this paper analyzed the factors contributing to the initial benefit selection and at-home survival rate. The results of the factor analysis showed that the probability of choosing home care was higher for males, lower age group, having family caregivers. On the other hand, in the case of dementia, the probability of choosing institutional care was high. As a result of the life table analysis, it was found that 13.1% of the initial home care users changed to institutional care, and about 71% of the moves take place between 2 and 4 years. The Cox proportional hazards regression model analysis showed that the likelihood of withdrawal from home care was higher: for women, for older, for those ...
IMPORTANCE The association between early exposure to animals and type 1 diabetes in childhood is not clear. OBJECTIVE To determine whether exposure to dogs during the first year of life is associated with the development of type 1 diabetes in childhood. DESIGN, SETTING, AND PARTICIPANTS A nationwide cohort study utilizing high-quality Swedish national demographic and health registers was conducted. A total of 840 593 children born in Sweden from January 1, 2001, to December 31, 2010, were evaluated. Type 1 diabetes was identified using diagnosis codes from hospitals and dispensed prescriptions of insulin. Cox proportional hazards regression models were used to assess the association between exposure to dogs and risk of type 1 diabetes in childhood. The possible association was further investigated by performing dose-response and breed group-specific analyses. The cohort was followed up until September 30, 2012. Data analysis was conducted from October 15, 2015, to February 8, 2017. EXPOSURES ...
A new study isuggests that people with atrial fibrillation who exercise have a reduced risk for cardiovascular disease and all-cause mortality.
In survival data analysis, the aim of fitting a Coxs proportional hazards (Coxs PH) model is to estimate the effect of covariates on the baseline hazard function. However, Coxs PH model makes a number of assumptions, which may be violated in many applications. Applying Coxs PH model without ensuring that its underlying assumptions are validated can lead to negative consequences on the resulting estimates. In this article, a generalization of the Coxs PH model in terms of the increment in cumulative hazard function taking a form similar to the Coxs PH model, with the extension that the increment in baseline cumulative hazard function is raised to a power function. The problem of parameter estimation for the parameters in that generalization of Coxs PH model will be solved using Bayesian inference. When the increment in cumulative hazard function is a gamma process, the likelihood has a semi-closed form, which allows posterior sampling to be carried out for the parameters, hence achieving ...
LB-371 The relationship between socioeconomic status (SES) and health has long been of interest to epidemiologists and social policy makers. We prospectively examined the association between SES and the risk of developing first primary cancers in the NIH-AARP Study, a cohort of 498,447 50-71 year olds without cancer at enrollment in 1995/96. We used highest attained education, reported at baseline, as a proxy for SES. During 5 years of follow-up, 34,955 cancers were identified in 8 state cancer registries. Cox proportional hazards models were utilized to estimate relative risks (RR) and 95% confidence intervals (95%CI) for subjects who did not complete high school compared to those with post-graduate education, stratified by sex. In age adjusted models, men with lower educational attainment had significantly increased risks of developing cancers of the lung (RR:4.27; 95% CI:3.64-5.00), head and neck (RR:1.88; 95%CI:1.38-2.58), esophagus (RR:3.34; 95% CI:2.13-5.23), stomach (RR:2.60; ...
where X1, X2,...,Xp denote a set of p explanatory variables that help to form this hazard rate at time t.. The coefficients, βk1,βk2,...,βkp for k=1,2,... can be estimated using a maximum likelihood methodology. The results obtained can be interpreted in much the same way as the results for a Cox proportional hazards model. More specifically, a positive valued estimate for βkj would suggest that an increase in the value of the variable j increases the hazard rate associated with the occurrence of the cause specific outcome k (i.e. shortens the length of time until the event occurs). Similarly, a negative valued estimate for βkj would suggest that an increase in the value of variable j decreases the hazard rate associated with the occurrence of the cause specific outcome k (i.e. lengthens the time until occurrence of the event). The fitted model results along with their p-values are presented in Table 2. For all analyses, SAS software was used; p≤0.05 was considered statistically ...
Type 2 diabetes is increasing globally and in Asia. The purpose of this study was to examine the association of a fit-fat index (FFI) with diabetes incidence among Japanese men. In total 5,014 men aged 18-64 years old, who had an annual health check up with no history of major chronic disease at baseline from 2002 to 2009 were observed. CRF was estimated via cycle ergometry. Overall, 7.6% of the men developed diabetes. The mean follow-up period was 5.3 years. Hazard ratios, 95% confidence intervals and P trend for diabetes incidence were obtained using the Cox proportional hazards model while adjusting for confounding variables ...
Type 2 diabetes is increasing globally and in Asia. The purpose of this study was to examine the association of a fit-fat index (FFI) with diabetes incidence among Japanese men. In total 5,014 men aged 18-64 years old, who had an annual health check up with no history of major chronic disease at baseline from 2002 to 2009 were observed. CRF was estimated via cycle ergometry. Overall, 7.6% of the men developed diabetes. The mean follow-up period was 5.3 years. Hazard ratios, 95% confidence intervals and P trend for diabetes incidence were obtained using the Cox proportional hazards model while adjusting for confounding variables ...
The goal of this project is to develop an interactive, Web-based Prognostigram program for adult patients with newly diagnosed cancer. The prognostic program creates individualized survival curves based on the Cox Proportional Hazards model of survival data from Barnes-Jewish Hospital (BJH) Oncology Data Services (ODS) and SEER*Stat (National Cancer Institute, Surveillance, Epidemiology, and End Results Software package). This program also includes important comorbid health information. Patient and physician focus groups were held to explore the utility of the program. Overall, both groups felt the program was informative and easy to use. Specific suggestions for improvement were made ... Read the full Final Report.. ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Likelihood based regression models, such as the normal linear regression model and the linear logistic model, assume a linear (or some other parametric) form for the covariate effects. We introduce the Local Scotinq procedure which replaces the liner form C Xjpj by a sum of smooth functions C Sj(Xj)a The Sj(.) s are unspecified functions that are estimated using scatterplot smoothers. The technique is applicable to any likelihood-based regression model: the class of Generalized Linear Models contains many of these. In this class, the Locul Scoring procedure replaces the linear predictor VI = C [email protected] by the additive predictor C ai ( hence, the name Generalized Additive Modeb. Local Scoring can also be applied to non-standard models like Coxs proportional hazards model for survival data. In a number of real data examples, the Local Scoring procedure proves to be useful in uncovering non-linear covariate effects. It has the
Results Three Cox proportional hazards models for prediction of 10-year recurrent vascular event risk were developed based on age and sex in addition to clinical parameters (model A), carotid ultrasound findings (model B) or both (model C). Clinical parameters were medical history, current smoking, systolic blood pressure and laboratory biomarkers. In a separate part of the dataset, the concordance statistic of model A was 0.68 (95% CI 0.64 to 0.71), compared to 0.64 (0.61 to 0.68) for model B and 0.68 (0.65 to 0.72) for model C. Goodness-of-fit and calibration of model A were adequate, also in separate subgroups of patients having coronary, cerebrovascular, peripheral artery or aneurysmal disease. Model A predicted ,20% risk in 59% of patients, 20-30% risk in 19% and ,30% risk in 23%.. ...
get file =C:Dataasa2gbcs.sav. compute hormonexnodes = (hormone-1)*nodes. exe. coxreg rectime with nodes hormone hormonexnodes /status=censrec(1) /method = enter hormone nodes hormonexnodes /print = corr. data list free /nodes. begin data 0 1 3 5 7 9 10 15 20 25 30 35 40 45 50 end data. *Creating the variance and covariance matrix. compute #vn = .008**2. compute #vh = .164**2. compute #vhxn = .015**2. compute #cov_n_h = .291*sqrt((#vn)*(#vh)). compute #cov_n_hxn =-.529*sqrt((#vn)*(#vhxn)). compute #cov_h_hxn =-.643*sqrt((#vh)*(#vhxn)). compute log_hr = -.606 + nodes*(.038). compute se = sqrt(#vh + nodes**2*(#vhxn) + 2*nodes*#cov_h_hxn). compute log_hr_l = log_hr - 1.96*se. compute log_hr_u = log_hr + 1.96*se. exe. graph /scatterplot(overlay) = nodes nodes nodes with log_hr log_hr_l log_hr_u (pair). ...
Inside a multivariate evaluation thinking about T stage, N stage, and histological subtype as co variables making use of Coxs proportional hazard regression model, TGase two expression was considerably associated with shorter DFS. In the non adenocarcinoma subtype, robust TGase two expression also was drastically connected with shorter DFS. In addition, a multivariate ana lysis to the non adenocarcinoma subtype looking at histologic kind, differentiation, and clinical stage as co variables, also showed powerful TGase two expression to become significantly correlated with shorter DFS, as indicated in Extra File three, Table S1. Inside the male NSCLC subgroups, strong TGase 2 expression was drastically linked to shorter DFS, however the association, according on the multi variate examination, was not significant. Discussion Preceding reports have posited cisplatin and doxor ubicin resistance roles for TGase two in NSCLC cells. During the present research, we showed that TGase two down regu lation ...
Adults, Association, Blood, Blood Cell, Cell, Death, Hazard Model, Measure, Mortality, Patients, Person, Probability, Proportional Hazard Model, Red Blood Cell, Regression, Risk, Risk Factors, Survival
Dr. Zhang will discuss some literature review and simulation results about frailty models and random effects based on the paper, "Proportional hazards models with frailties and random effects," by John OQuigley and Janez Stare, (Statistics in Medicine, 2002, 21:3219-3233). ...
An activity hazard analysis is a report that includes injury and illness programs directly related to supervision quality, understanding of work hazards, a properly trained workforce, and a safe work...
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Estimate the regression coefficients and the baseline hazard of proportional hazard Cox models using maximum penalised likelihood. A non-parametric smooth estimate of the baseline hazard function is provided.. ...
COX1_DICDI (O21042 ), COX2_ACHDO (P29870 ), COX2_ACOIG (Q38S50 ), COX2_ACOWI (P50672 ), COX2_ADABI (P29871 ), COX2_AEDAE (P50692 ), COX2_AILFU (Q3L6W7 ), COX2_AILME (Q2Y0B9 ), COX2_ALBCA (P48889 ), COX2_ALBTU (Q09334 ), COX2_ALLMI (O47870 ), COX2_ALOPA (P98024 ), COX2_ANAPL (P98019 ), COX2_ANIIM (Q38S38 ), COX2_ANOGA (P34840 ), COX2_ANOQU (P33505 ), COX2_ANTAM (Q37369 ), COX2_AOTNI (Q7IC90 ), COX2_APIFL (P50267 ), COX2_APIKO (P50268 ), COX2_APILI (P20375 ), COX2_APOMY (Q38S35 ), COX2_APOSM (Q38S29 ), COX2_APOSY (P50673 ), COX2_APTAU (O03889 ), COX2_ARATH (P93285 ), COX2_ARTSF (Q37706 ), COX2_ARVSO (Q38S26 ), COX2_ASCSU (P24882 ), COX2_ASHGO (Q7YFV7 ), COX2_ATEMI (Q7J6G4 ), COX2_BACP3 (Q03438 ), COX2_BACPE (Q04441 ), COX2_BACSU (P24011 ), COX2_BALBO (Q599A0 ), COX2_BALMU (P41294 ), COX2_BALPH (P24986 ), COX2_BATGR (Q38S23 ), COX2_BERBO (Q38S20 ), COX2_BETVU (P98012 ), COX2_BISBI (Q37416 ), COX2_BISBO (P68296 ), COX2_BOSGA (P68295 ), COX2_BOSIN (P68553 ), COX2_BOSJA (P68294 ), COX2_BOSMU (P68554 ...
Presmoothed estimators of survival, density, cumulative and non-cumulative hazard functions with right-censored survival data.. ...
I guess you can imagine what happened next, hehehe. The picture is taken in February 2008. Mum (back then still my CCO) was pretty gutsy as we both knew each other just about a month.
Coxs Bazar will be a testing ground for the UN Secretary-Generals Prevention Agenda and for the concept of preventing violent extremism.
rat_hr. 1 MGLRSSCFVL TLQDPPLGEP HEGRRVMESM PSFLKDTPAW EKTAPVNGIV GQEPGTSPQD 61 GLHHGALCLG EPVPFWRGVL SAPDSWLPPG FLQGPKDTLS VVEGEGSRNG ERKANWLGSK 121 EGLRWKEAML AHPLAFCGPA CPPRYGPLIP EHSSGHPKSD PVAFRPLHCP FLLETKILER 181 APFWVPTCLP PYLMSSLPPE RSYDWPLAPS PWVYSGSQPK VPSAFSLGSK GFYHKDPNIL 241 RPAKEPLAAS ESGMLGLAPG GHLQQACDAE GPSLHQRDGE TGAGRQQNLC PVFLGYPDTV 301 PRTPWPSCPP GLVHTLGNVW AGPGSNSFGY QLGPPVTPRC PSPGPPTPPG GCCSSHLPAR 361 EGDPGPCRKC QDSPEGSSSG PGESSEERNK AGSRASPPSH HTKLKKTWLT RHSEQFECPG 421 GCPGKGESPA TGLRALKRAG SPEVQGARGP APKRPSHTFP GTGRQGARAW QETPETSTGS 481 KAEAQQQEEQ RGPRDGRIRL RESRLEDTSC QHHLAGVTQC PSCVQAAGEV EILTSHSQKS 541 HKLPLEEKPL EEDSCATSEE GGGSSPEASI NKGLAKHLLS GLGDRLCRLL RKEREALAWA 601 QREGQGPAMT EDSPGIPHCC SRCHHGLFNT HWRCSHCSHR LCVACGRIAG AGKNREKTGS 661 REQRTDDCAQ EAGHAACSLI LTQFVSSQAL AELSTVMHQV WAKFDIRGHC FCQVDARVWA 721 PGDGGQQKEP TEKTPPAPQL SCNGDSNRTK DIKEETPDST ESPAEDRAGR SPLPCPSLCE 781 LLASTAVKLC LGHERIHMAF APVTPALPSD DRITNILDSI IAQVVERKIQ EKALGPGLRA 841 GSGLRKGLSL PLSPVRTQLS ...
450 patients with , 70% stenosis in ≥1 epicardial coronary artery (75% men, median age 63 years, median LV ejection fraction (EF) 22 %, median ESVi 106ml, median scar % of 29% ) underwent delayed hyperenhancement-MRI (Siemens 1.5-T scanner, Erlangen, Germany) between 2002-2006. CMR evaluation included long and short axis assessment of LV and RV function on balanced steady state free precession images along with assessment of LV and RV myocardial scar (on phase-sensitive inversion recovery DHE-CMR sequence ~ 10-20 minutes after injection of 0.2 mmol/kg of Gadolinium dimenglumine). Scar was identified as regions of interest , 2 SD above normal myocardium. Cox proportional hazards survival modeling, using a primary end-point of all-cause mortality, was used to risk-adjust comparisons. MR severity was determined by echocardiography and assessed by width of the vena contracta. Cox proportional hazards survival modeling, using a primary end-point of all-cause mortality, was used to risk-adjust ...
Background: The USA is one of only a few advanced economies globally that does not guarantee its workers paid sick leave. While there are plausible reasons why paid sick leave may be linked to mortality, little is known empirically about this association. Methods: In a pooled USA nationally-representative longitudinal sample of 57,323 working adults aged 18-85 years from the National Health Interview Surveys 2000-2002, paid sick leave was examined as a predictor of all-cause and cause-specific mortality. Multivariate Cox proportional hazards models were used to estimate the impact of paid sick leave on mortality. Results: Having paid sick leave through ones job was associated with 10% (hazards ratio, HR = 0.90; 95% CI = 0.81-0.996; p = 0.04), 14% (HR = 0.86; 95% CI = 0.74-0.99; p = 0.04), and 22% (HR = 0.78; 95% CI = 0.65-0.94; p = 0.01) significantly lower hazards of all-cause mortality after mean follow-up times of 11.1, 6.5, and 4.5 years, respectively. This study further identified associations of
Background: Both dietary and serum levels of inorganic phosphate (Pi) have been linked to development of cancer in experimental studies. This is the first population-based study investigating the relation between serum Pi and risk of cancer in humans. Methods: From the Swedish Apolipoprotein Mortality Risk (AMORIS) study, we selected all participants (,20 years old) with baseline measurements of serum Pi, calcium, alkaline phosphatase, glucose, and creatinine (n = 397,292). Multivariable Cox proportional hazards regression analyses were used to assess serum Pi in relation to overall cancer risk. Similar analyses were performed for specific cancer sites. Results: We found a higher overall cancer risk with increasing Pi levels in men (HR: 1.02 (95% CI: 1.00-1.04) for every SD increase in Pi), and a negative association in women (HR: 0.97 (95% CI: 0.96-0.99) for every SD increase in Pi). Further analyses for specific cancer sites showed a positive link between Pi quartiles and the risk of cancer of ...
Background: Coronary artery calcium (CAC) predicts major adverse cardiovascular events (MACE) beyond Framingham risk factors (RF) across multiple ethnic groups within the United States. However, its value in other, non-US populations is unknown.. Methods: We prospectively obtained data on RF and MACE in asymptomatic adults from the registry-based ESCORT Study (4502 Koreans) and the population-based Framingham Heart Study (FHS, 3141 Whites), who underwent computed tomography to assess CAC. The primary composite endpoint of MACE included CV death, acute myocardial infarction and unstable angina with revascularization. We compared association of traditional RF and CAC with MACE in the two cohorts using multivariate Cox proportional hazard regression analysis, examining CAC both as a categorical variable using established cut-points and as a continuous variable using log 2 [CAC + 1]. We tested for interaction between ethnicity and CAC categories.. Results: Over median 55 (ESCORT) or 60 (FHS) month ...
For each participant we calculated time at risk until date of each outcome, date of emigration, or the end of the study period (31 December 2010), whichever occurred first. We used Cox proportional hazards regression for estimation of age adjusted and multivariable adjusted hazard ratios and their 95% confidence intervals for prespecified categories of milk intake (,200, 200-399, 400-599, and ≥600 g/d) and for continuous milk intake for each 200 g/d, corresponding to one glass of milk. Because other dairy products may have different health effects from that of milk,18 23 we additionally studied intake of fermented milk and cheese as exposures. The proportional hazard assumptions were confirmed graphically by log-log plots. We assessed non-linear trends of risk using restricted cubic-spline Cox regression with three knots placed at centiles 10, 50, and 90 of the milk product intake.43. We used the directed acyclic graph approach44 to select suitable covariates for the multivariable model (see ...