The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which catalyzes the first step in proline catabolism. The function of this protein has not been determined. [provided by RefSeq, Jul 2008 ...

Fabro et al. Plant Physiol Biochem. 2020. Proline dehydrogenase (ProDH) is a flavoenzyme that catalyzes the oxidation of proline (Pro) into Δ1-pyrroline-5-carboxylate (P5C). In eukaryotes, ProDH coordinates with different Pro metabolism enzymes to control energy supply or stress responses signaling. Heterologous expression and crystallization of prokaryotic enzymes provided key data on their active center, folding capacity and oligomerization status. In contrast, eukaryotic ProDHs have not been crystallized so far, and their study as recombinant proteins remains limited. Plants contain two isoforms of ProDH with non-redundant functions. To contribute to the study of these enzymes, we describe the modeling, expression in E. coli, purification, and characterization of the Arabidopsis isoenzymes, AtProDH1 and AtProDH2. The 3D model suggested that both proteins adopt a distorted barrel structure (βα) with a cap formed by N-terminal α helices. The expression of two types of N-terminal deletion ...

SWISS-MODEL Template Library (SMTL) entry for 1tj2.2. Crystal structure of E. coli PutA proline dehydrogenase domain (residues 86-669) complexed with acetate

Proline catabolism is a common function in both prokaryotes and in the mitochondria of eukaryotic cells. In Salmonella typhimurium and Escherichia coli proline can be utilized as a sole source of carbon, nitrogen or energy. Proline utilization (put) requires the expression of the two genes of the put operon: the putP gene, which encodes proline permease, and the putA gene, which encodes a multifunctional membrane-associated dehydrogenase that degrades proline to glutamate. PutA protein also autogenously regulates transcription of the put operon. The deduced amino acid sequence of PutA exhibits similarities to eukaryotic protein kinases and to other dehydrogenases which catalyze reactions similar to those of PutA. Induction of the put operon requires proline, oxygen, or another terminal electron acceptor, and available membrane binding sites. The following model explains the regulation: under inducing conditions, PutA binds to the membrane where it is enzymatically active, but when the ...

Studies on Germination, Seedling Vigour, Lipid Peroxidation and Proline Metabolism in B. juncea Seedlings Under Hg-Stress. Heavy metals pose a serious threat to the en..

Amino Acids and DerivativesProline and 4-hydroxyprolineProline, 4-hydroxyproline uptake and utilization Proline dehydrogenase (EC 1.5.99.8) (Proline oxidase) ...

Staphylococcus aureus has the ability to adhere and cause infections in a wide variety of niches within a human host. The overall hypothesis of this project is...

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

Biochemistry, Metabolism:, Hereditary Factors:, Origin:, Pathology:, Strains: AKR, AU, C57BL/6, DBA/2 (212), L (P), LP, P, SIMPSON, PL (PLA, PLB), RF (W), SJL, SM, ST/B (STB), SWR, 129, RIII/S. ...

Gene target information for ZADH2 - zinc binding alcohol dehydrogenase domain containing 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Salmonella typhimurium and Escherichia coli can utilize proline as a sole carbon or nitrogen source. Proline utilization requires the expression of the two genes in the put operon: the putP gene, which encodes proline permease, and the putA gene, which encodes a bifunctional membrane-associated dehydrogenase that degrades proline to glutamate. The PutA protein also autogenously regulates transcription of the put operon. Induction of the put operon requires proline, oxygen (or another terminal electron acceptor), and available membrane binding sites. A simple model explains the regulation: under inducing conditions the PutA protein binds to the membrane where it is enzymatically active, but when the intracellular concentration of proline is low or when few functional membrane binding sites are available, the PutA protein accumulates in the cytoplasm where it represses transcription of the put operon. This change in cellular localization seems to be at least partly induced by changes in the redox ...

Salt stress is one of the important abiotic stress factors. Proline is generally thought to play an important role in the improvement of salt tolerance in plants. In the present study, we discussed the relationship between free proline accumulation and the expression patterns of the genes that play roles in proline metabolism (P5CS, P5CR, PDH, P5CDH) under 90 mM NaCl stress. We used three salt tolerant M3 generation soybean mutant plants (Ataem-7/150-68, S04-05/150-2 and S04-05/150-114). The mutants belonging to M3 generation are determined as tolerant to 90 mM NaCl. The free proline contents of the salt-tolerant mutants were measured at the upper phase of the extract with respect to toluene. We observed 1.96-, 2.43- and 1.14-fold increases in the free proline accumulation of Ataem-7/150-68, S04-05/150-2 and S04-05/150-114 mutant plants after 7 days of salt treatment in accordance with control groups, respectively. The expression analyses were performed using specific primers designed for ...

The content of the free proline in roots of Xingjiang poplar,dryland willow,Chinese scholar tree,and four-season cloves inundated with sea water was tested.The result indicated that the quantity of the free proline in the roots varied.

The largest differences among strains were observed in the reactions mediated by the malic enzymes and the phosphoenolpyruvate carboxykinase, the TCA cycle, and the fluxes related to proline metabolism and hydroxylation. As the ΔputA_pET strain was not able to catabolize proline, proline addition did not have an impact on the flux distribution, which resembled that of the wt_pET strain grown on glucose only. However, the ΔputA_pET strain virtually substituted endogenous proline biosynthesis with the uptake of extracellular proline. In contrast, proline addition increased the acetate secretion rate by almost 25%, in the wt_pET strain, reversed the flux between α-KG and glutamate towards α-KG synthesis, increased the TCA flux from α-KG to succinate by almost 40%, and activated the conversion of malate to pyruvate. In all other cases, independently of proline addition, this gluconeogenetic reaction was not active. The oxidative decarboxylation of malate catalyzed by the malic enzymes ScfA ...

CP000667.PE136 Location/Qualifiers FT CDS complement(147749..148963) FT /codon_start=1 FT /transl_table=11 FT /locus_tag=Strop_0136 FT /product=acyl-CoA dehydrogenase domain protein FT /note=PFAM: acyl-CoA dehydrogenase domain protein; FT Acyl-CoA dehydrogenase, type 2, C-terminal domain FT /db_xref=EnsemblGenomes-Gn:Strop_0136 FT /db_xref=EnsemblGenomes-Tr:ABP52621 FT /db_xref=GOA:A4X171 FT /db_xref=InterPro:IPR006089 FT /db_xref=InterPro:IPR006091 FT /db_xref=InterPro:IPR009075 FT /db_xref=InterPro:IPR009100 FT /db_xref=InterPro:IPR013786 FT /db_xref=InterPro:IPR036250 FT /db_xref=InterPro:IPR037069 FT /db_xref=UniProtKB/TrEMBL:A4X171 FT /protein_id=ABP52621.1 FT /translation=MAEFSLDLTEEQRDLRDWVHGFASEVVRPAAAEWDAREETPWPII FT QEAAKVGLYGFEFLATCWGDPSGLSLPVACEELFWGDSGIGLSIFGTGLAVAAIYGTGT FT PEQLMEWVPQCFGDLDSPAVAAFCTSEPEAGSDVGAMRTRAVYDEAADEWVLSGQKSYA FT TNGGIAGVHVVTASVDPELGSRGQAAFVVPPGTPGLAATRKLRKLGLRASHTADVFLDD FT ...

CP000667.PE429 Location/Qualifiers FT CDS 488729..489889 FT /codon_start=1 FT /transl_table=11 FT /locus_tag=Strop_0429 FT /product=acyl-CoA dehydrogenase domain protein FT /note=PFAM: acyl-CoA dehydrogenase domain protein; FT Acyl-CoA dehydrogenase, type 2, C-terminal domain FT /db_xref=EnsemblGenomes-Gn:Strop_0429 FT /db_xref=EnsemblGenomes-Tr:ABP52914 FT /db_xref=GOA:A4X214 FT /db_xref=InterPro:IPR006091 FT /db_xref=InterPro:IPR009075 FT /db_xref=InterPro:IPR009100 FT /db_xref=InterPro:IPR013786 FT /db_xref=InterPro:IPR036250 FT /db_xref=InterPro:IPR037069 FT /db_xref=UniProtKB/TrEMBL:A4X214 FT /protein_id=ABP52914.1 FT /translation=MSPLDLLDVDSSLSAEERQIRAVVRQLVDEQVRPHVAGWYEEGRV FT PARELAREFGRLGLLGMHLTGYGCAGSSAVAYGLACLELEAGDSGVRSLVSVQGALAMY FT AIWRYGSTEQKQHWLPAMAAGETIGCFALTEPDHGSDPASMTTRARRDGDDWVLHGTKM FT WITNATIADVAVIWARTDEGVRGFAVPTSTPGVAVREIRRKMSLRASVTGEISLDDVRL FT PAAARLPDAVGLKAPLGCLTEARHGIVWGALGAARDCLETTLEYAGSRTQFGRPLAGFQ FT ...

Amino Acids and DerivativesProline and 4-hydroxyprolineA Hypothetical Protein Related to Proline Metabolism Pyrroline-5-carboxylate reductase (EC 1.5.1.2) ...

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

To assess the ameliorative effects of exogenous proline application on salinity stress, 20, 35 and 50-day old seedlings of two lupine varieties (i.e., Giza 1 and Giza 2) grown on a saline soil (i.e., 6.35 - 6.45 dS m-1) were sprayed with 0 (tap water as a control), 3, 6 or 9mM proline. This study was conducted in two seasons of 2012/2013 and 2013/2014. All proline levels caused a significant incre ...

Proline Benefits - Info on benefits of proline, facts, proline side effects, dosage, health benefits, keeps muscles and joints flexible, main component of collagen, adverse effects and more.

In many plants, free proline accumulates in response to the imposition of a wide range of biotic and abiotic stresses. Controversy has surrounded the extent to which this shift in nitrogen metabolism

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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...

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25I-NBOH (NBOH-2CI, Cimbi-27) je fenetilaminski halucinogen. On deluje kao potentan agonist 5HT2A receptora,[1][2] sa Ki od 0,061 nM na ljudskom 5HT2A receptoru, te je dvanaest puta potentniji od liganda 2C-I. In vitro testovi su pokazali da ovo jedinjenje deluje kao agonist, ali rezultati životinjskih studija nisu objavljeni. Dok su N-benzilni derivati 2C-I liganda znatno povećavali potentnost, N-benzil derivati 2,5-dimetoksi-4-jodoamfetamina su neaktivni.[3] ...

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abstract = {The N-methyl-d-aspartate receptor (NMDAR) coagonists glycine, d-serine and l-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We conducted the first genome-wide association study of concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of human subjects from the general population (N=414). Genetic variants at chromosome 22q11.2, located in and near PRODH (proline dehydrogenase), were associated with l-proline in plasma ($beta$=0.29; P=6.38 $times$ 10(-10)). The missense variant rs17279437 in the proline transporter SLC6A20 was associated with l-proline in CSF ($beta$=0.28; P=9.68 $times$ 10(-9)). Suggestive evidence of association was found for the d-serine plasma-CSF ratio at the d-amino-acid oxidase (DAO) gene ($beta$=-0.28; P=9.08 $times$ 10(-8)), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) constituted the most ...

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

In enzymology, an arginine N-succinyltransferase (EC 2.3.1.109) is an enzyme that catalyzes the chemical reaction succinyl-CoA + L-arginine ⇌ {\displaystyle \rightleftharpoons } CoA + N2-succinyl-L-arginine Thus, the two substrates of this enzyme are succinyl-CoA and L-arginine, whereas its two products are CoA and N2-succinyl-L-arginine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-arginine N2-succinyltransferase. Other names in common use include arginine succinyltransferase, AstA, arginine and ornithine N2-succinyltransferase, AOST, AST, and succinyl-CoA:L-arginine 2-N-succinyltransferase. This enzyme participates in arginine and proline metabolism. As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YLE. Vander Wauven C, Jann A, Haas D, Leisinger T, Stalon V (1988). N2-succinylornithine ...

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Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of ...

Data Availability StatementThe datasets used and/or analysed during the current research are available in the corresponding writer on reasonable demand. prolin-level in urine bloodstream and CSF. Furthermore, a minimal vitamin-B6 serum worth was found, in keeping with a HPII leading to extra pyridoxine seizures and insufficiency. The gene sequencing verified two previously unidentified compound heterozygous variations (gene (type:entrez-nucleotide,attrs:text:NM_003748.3″,term_id:238859538″,term_text:NM_003748.3″NM_003748.3) Intron 1: c.62?+?1G?>?A - heterozygous and gene (type:entrez-nucleotide,attrs:text:NM_003748.3″,term_id:238859538″,term_text:NM_003748.3″NM_003748.3) Exon 5 c.349G?>?C, p.(Asp117His normally) - heterozygous). Under high-dose vitamin-B6 therapy no more seizures occurred. Bottom line We explain two book gene, Epilepsy, Supplement B6 fat burning capacity, Proline Background Hyperprolinemia type 2 (HPII) can be an autosomal recessive ...

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redline proline serial number 06598 found at portland oregon auto swap 2015. 1977 redline proline pre gusset repaired in the 80s and powder coated repo decals ...

In 2006 Proline unveiled their first carbon handles featuring the patent pending Reverse Radius Technology. The first handle that actually improves your riding by making handle passes easier has only been made better for 2007. We have improved the construction and look for this year. Each handle comes with an extra grip to help customize your ride. ...

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