Full Text - Purpose: This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years).Results: We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC pathological staging system, including 10.7% upstaged and 42.1% downstaged. The receiver operating characteristics analysis showed that the new staging system had a better role in predicting breast cancer-specific survival (BCSS) compared with 7th edition staging (P<0.001). The results of the multivariate prognostic analysis showed that the hazard ratio of BCSS increased with the 8th AJCC stages, while the 7th anatomic stages had no significant difference in BCSS.Conclusions: The novel pathological staging system could provide more accurate prognostic stratification for young women with breast cancer because of the high proportion of stage migration.Patients and Methods:
TY - JOUR. T1 - Extratumoral vascular invasion is a significant prognostic indicator and a predicting factor of distant metastasis in non-small cell lung cancer. AU - Shimada, Yoshihisa. AU - Ishii, Genichiro. AU - Hishida, Tomoyuki. AU - Yoshida, Junji. AU - Nishimura, Mitsuyo. AU - Nagai, Kanji. PY - 2010/7. Y1 - 2010/7. N2 - INTRODUCTION: Vascular invasion is thought to be a fundamental step in hematogenous metastasis. The aim of this study was to assess whether the qualitative evaluation of vascular invasion according to its location (intratumoral or extratumoral) could provide an appropriate means of predicting the prognostic outcome and potential patterns of recurrence in non-small cell lung cancer. METHODS: We reviewed the cases of 1000 consecutive patients in whom complete resection of non-small cell lung cancer had been performed. Sections stained by the Victoria blue van Gieson method were examined for the presence of vascular invasion and the evaluation of its location (v0: absence, n ...
TY - JOUR. T1 - Results and prognosis following surgery for malignant tumors of the skull base. AU - Jackson, Ian T.. AU - Bailey, M. Hugh. AU - Marsh, W. Richard. AU - Juhasz, Peter. PY - 1991. Y1 - 1991. N2 - A series of 155 malignant craniofacial tumors referred to a specialized craniofacial center for surgical treatment are presented. One quarter of these were primary and three quarters recurrent. The statistics of long‐term follow‐up are presented, and it is concluded that this type of surgery for these difficult problems is worthwhile. The increasing experience gained from operating on and following up these patients is presented.. AB - A series of 155 malignant craniofacial tumors referred to a specialized craniofacial center for surgical treatment are presented. One quarter of these were primary and three quarters recurrent. The statistics of long‐term follow‐up are presented, and it is concluded that this type of surgery for these difficult problems is worthwhile. The increasing ...
The mRNA as well as protein expression of SASH1 was strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in colorectal liver metastases. In contrast, SASH1 expression was not significantly altered in benign adenomas and in early stage lesions (UICC I). Around 40% of primary colon tumours tested (n=113) showed a 10-fold or stronger reduction in SASH1 expression, compared to normal colon mucosa. Decreased SASH1 mRNA expression was correlated with the occurrence of metachronous distant metastasis, and multivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival (Rimkus et al., 2006). Recently, these results were confirmed on an independent patient collective of stage II colon cancer (n=179 patients), confirming that decreased SASH1 expression is an independent negative prognostic factor in colon cancer, allowing to distinguish high-risk patients in early, locally restriced stages of the disease ...
Systemic immune-inflammation index as a useful prognostic indicator predicts survival in patients with advanced gastric cancer treated with neoadjuvant chemotherapy Li Chen,1,* Ying Yan,2,* Lihua Zhu,3 Xiliang Cong,1 Sen Li,1 Shubin Song,1 Hongjiang Song,1 Yingwei Xue1 1Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang, 2Department of Internal Oncology, Harbin The First Hospital, Harbin, Heilongjiang, 3Department of Pathogen Biology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China *These authors contributed equally to this work Background and objective: A novel systemic immune-inflammation index named SII (SII=N×P/L), which is based on neutrophil (N), platelet (P) and lymphocyte (L) counts, has emerged and reflects comprehensively the balance of host inflammatory and immune status. We aimed to evaluate the potential prognostic significance of SII in patients with
TY - JOUR. T1 - Survival predictors in patients with node-negative gastric carcinoma. AU - Lee, Chin Chun. AU - Wu, Chew Wun. AU - Lo, Su Shun. AU - Chen, Jen Hao. AU - Li, Anna F.Y.. AU - Hsieh, Mao-Chih. AU - Shen, King Han. AU - Lui, Wing Yiu. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Background: Presence or absence of nodal metastasis influences outcome of gastric cancer patients. This study gives insight into survival predictors and clinicopathological features of node-negative gastric adenocarcinoma. Methods: Between 1988 and 1999, 689 gastric cancer patients without other cancer or gastrectomy for benign disease who underwent curative resection were enrolled in this study. Clinicopathological data in patients with node metastasis were compared with those without. Results: The survival rate at 5 and 10 years for node-negative cases was 91.7% and 89.7%, respectively. On univariate analysis, node-negative patients were characterized by frequent location in the lower two-thirds of the stomach ...
Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC).. Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial least squares discrimination analysis (OPLS-DA) and 1.5-fold expression change criterion methods. The prognosis prediction model based on the lncRNA signatures and clinical parameters were evaluated using the 5-fold cross validation method.. A total of 84 out of 3199 lncRNAs were significantly associated with the survival of patients with HNSCC. Using the OPLS-DA and 1.5-fold change selection criterion, 5 lncRNAs (KTN1-AS1, LINC00460, GUSBP11, LINC00923 and RP5-894A10.6) were further selected. The prediction power of each combination of the 5 lncRNAs was evaluated through the receiver ...
TY - JOUR. T1 - Glasgow prognostic score is an independent marker for poor prognosis with all cases of epithelial ovarian cancer. AU - Omichi, Chiaki. AU - Nakamura, Keiichiro. AU - Haraga, Junko. AU - Masuyama, Hisashi. AU - Hiramatsu, Yuji. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Inflammatory markers are important prognostic factors in various cancers. This study investigated whether inflammatory markers of the Glasgow prognostic score (GPS) predicted progression-free survival (PFS) and overall survival (OS) for patients with all cases of epithelial ovarian cancer (OC). Pretreatment GPS was examined for the correlations with PFS and OS in 216 patients in all stages of epithelial OC. Statistical analyses were performed using the Mann-Whitney U-test. PFS and OS were analyzed using the Kaplan-Meier method. Coxs proportional hazard regression was used for univariate and multivariate analyses. For all patients, the median PFS was 35.1 months, and median OS was 46.7 months; follow-up range was 1-162 ...
Breast cancer prognosis may be worse among black women than among white women regardless of the subtype of breast cancer. These results were presented at the 2013 annual meeting of the American Association for Cancer Research (AACR).. Its long been known that breast cancer prognosis varies by race among women in the United States, with black women tending to have worse outcomes than white women. Some of this variability has been attributed to the fact that black women have higher rates of triple-negative breast cancer than women of other races. How race affects prognosis among women with certain subtypes of breast cancer, however, has been uncertain.. To explore the relationship between race and prognosis by subtype of breast cancer, researchers evaluated 1,688 breast cancer survivors who participated in the Life After Cancer Epidemiology and Pathways studies. Women have been followed for more than six years.. ...
TY - JOUR. T1 - DPP4/CD26 overexpression in urothelial carcinoma confers an independent prognostic impact and correlates with intrinsic biological aggressiveness. AU - Liang, Peir In. AU - Yeh, Bi Wen. AU - Li, Wei Ming. AU - Chan, Ti Chun. AU - Chang, I. Wei. AU - Huang, Chun Nung. AU - Li, Ching Chia. AU - Ke, Hung Lung. AU - Yeh, Hsin Chih. AU - Wu, Wen Jeng. AU - Li, Chien Feng. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Urothelial carcinoma (UC) is common cancer worldwide. The molecular aberrations regarding tumor progression remain unclear. Pericellular proteolysis is crucial in tumorigenesis, but its significance is unexplored in UC. By data mining the datasets in Gene Expression Omnibus, specifically focus on the proteolysis pathway, and followed by a preliminary validation in a pilot batch of tumor samples, we identified that the upregulation of dipeptidyl peptidase 4 (DPP4) was most significantly associated with clinical aggressiveness of UCs. Quantitative RT-PCR confirmed upregulation of DPP4 ...
Individualized approaches to prognosis are crucial to effective management of cancer patients. We developed a methodology to assign individualized 5-year disease-specific death probabilities to 1,222 patients with melanoma and to 1,225 patients with breast cancer. For each cancer, three risk subgroups were identified by stratifying patients according to initial stage, and prediction probabilities were generated based on the factors most closely related to 5-year disease-specific death. Separate subgroup probabilities were merged to form a single composite index, and its predictive efficacy was assessed by several measures, including the area (AUC) under its receiver operating characteristic (ROC) curve. The patient-centered methodology achieved an AUC of 0.867 in the prediction of 5-year disease-specific death, compared with 0.787 using the AJCC staging classification alone. When applied to breast cancer patients, it achieved an AUC of 0.907, compared with 0.802 using the AJCC staging classification
Background: This study was to investigate the prognostic significance of clinicopathologic characteristics in patients with clear-cell carcinoma (CCC) of the ovary.. Materials and methods: Two hundred and one patients with CCC of the ovary were registered in the Korean Gynecologic Oncology Group. The Korean Gynecologic Pathology Study Group reviewed the pathological slides centrally, using a universal grading system. The prognostic significances of clinicopathologic factors were evaluated by multivariate analysis.. Results: Most of the patients were diagnosed at an early stage (stage I, 61.3%), and the overall 5-year survival rate was 57%. Early-stage disease showed a favorable prognosis, but advanced diseases showed poor prognosis. Stage of disease was the only significant prognostic factor on multivariate analysis (P , 0.001). However, universal grade and residual tumor also showed prognostic significance on the forward stepwise likelihood ratio test. There was no survival difference observed ...
Oesophageal adenocarcinoma is an aggressive malignancy with propensity for early lymphatic and haematogenous dissemination. Since conventional TNM staging does not provide accurate prognostic information, novel molecular prognostic markers and potential therapeutic targets are subject of intense res …
Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor prognosis and increased risk of antiestrogen therapy failure. Here we quantify for the first time levels of Stat5a and Stat5b over breast cancer progression, and explore their potential association with clinical outcome. Stat5a and Stat5b protein levels were quantified in situ in breast-cancer progression material. Stat5a and Stat5b transcript levels in breast cancer were correlated with clinical outcome in 936 patients. Stat5a protein was further quantified in four archival cohorts totaling 686 patients with clinical outcome data by using multivariate models. Protein levels of Stat5a but not Stat5b were reduced in primary breast cancer and lymph node metastases compared with normal epithelia. Low tumor levels of Stat5a but
Purpose: We evaluated prognostic value of the 8th edition of the American Joint Committee on Cancer/International Union for Cancer Control (AJCC/UICC) staging system for nasopharyngeal cancer and investigated whether tumor volume/metabolic information refined prognostication of anatomy based staging system. Materials and Methods: One hundred thirty-three patients with nasopharyngeal cancer who were staged with magnetic resonance imaging (MRI) and treated with intensity-modulated radiotherapy (IMRT) between 2004 and 2013 were reviewed. Multivariate analyses were performed to evaluate prognostic value of the 8th edition of the AJCC/UICC staging system and other factors including gross tumor volume and maximum standardized uptake value of primary tumor (GTV-T and SUV-T). Results: Median follow-up period was 63 months. In multivariate analysis for overall survival (OS), stage group (stage I-II vs. III-IVA) was the only significant prognostic factor. However, 5-year OS rates were not significantly ...
Poor prognosis patients may be considered candidates for more aggressive treatment strategies, while good prognosis patients may be treated with less burdensome interventions, for example by less toxic chemotherapy regimens [2, 3]. A serious, uncontrolled infection at the time of diagnosis is a less favourable prognostic factor. It is linked with a less favourable prognosis. You will also hear very guarded prognosis which is a notch lower towards poor. Prognosis for psoriatic arthritis PsA can be a serious chronic inflammatory condition that can cause significant pain and, in severe cases, disability. A higher-grade cancer may grow and spread more quickly and may require immediate or more aggressive treatment. Psychopathy has often been considered untreatable. The doctor is not exactly sure of what the patients probability for recovery might be, but they still believe that the patient has a (slight) chance of recovery. Lastly, but probably most important, is how active the disease is at the ...
S100A6 has been implicated in a variety of biological functions as well as tumorigenesis. In this study, we investigated the expression status of S100A6 in relation to the clinicopathological features and prognosis of patients with gastric cancer and further explored a possible association of its expression with epigenetic regulation. S100A6 expression was remarkably increased in 67.5% of gastric cancer tissues as compared with matched noncancerous tissues. Statistical analysis demonstrated a clear correlation between high S100A6 expression and various clinicopathological features, such as depth of wall invasion, positive lymph node involvement, liver metastasis, vascular invasion, and tumor-node metastasis stage (P < 0.05 in all cases), as well as revealed that S100A6 is an independent prognostic predictor (P = 0.026) significantly related to poor prognosis (P = 0.0004). Further exploration found an inverse relationship between S100A6 expression and the methylation status of the seventh and ...
Abstract #3010 Vascular invasion, encompassing both lymphovascular (LVI) and blood vascular invasion (BVI), influences breast cancer patient prognosis. We have previously shown, using an immunohistochemical approach to distinguish between LVI and BVI in a well characterized group of 177 consecutive paraffin-embedded specimens breast cancer patients (52 LN+ and 125 LN-), that VI was detected in 32% of specimens and that 96% of such VI were invasion of lymphatic vessels. The presence of LVI was significantly associated with the presence of metastasis, recurrence and worse disease free interval (DFI) and overall survival (OS). In multivariate analysis, LVI was an independent poor prognostic factor. This original study has been expanded by examining LVI, assessed by podoplanin staining, in 1000 LN-, early stage, breast cancers. In addition to verifying initial results showing the prognostic power of detection of LVI in early stage tumours, it also allowed an examination of LVI in histological and ...
BACKGROUND: Patients who have suffered from cerebral ischemia have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that cerebral ischemia has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. METHODS AND RESULTS: We studied 1020 patients with cerebral ischemia and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new ischemic events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of ischemic stroke (using summary
It has been demonstrated in the previous studies that cytogenetics and molecular abnormalities were independent predictors for the prognosis of AML patients [36]-[38]. However, in our study, adverse cytogenetic abnormalities only accounted for 8.6% (n = 93) of patients. The majority of patients was with intermediate and favorable cytogenetics and showed no difference in survival. As Ara-C forms the backbone of the treatment regimen, understanding the contribution of pharmacogenetics to Ara-C response may help dissection of AML with distinct prognosis, so as to individualize chemotherapy and potentially improve the outcomes of AML patients.. In our study, we observed single SNP and SNP-SNP interactions in the Ara-C transport pathway, which could account for the interpatient variability of treatment outcomes in AML patients. When tested independently, both SNP rs324148 and rs9394992 in the SLC29A1gene contributed to Ara-C resistance in patients with AML who received Ara-C based treatment, and they ...
The aim of the study was to evaluate the prognostic power of new classifications of N descriptor created basing on the number (NLN) and the ratio of metastatic lymph nodes (RLN) in NSCLC compared to the current classification (CLN). The data of 529 patients with NSCLC operated with the intention of radical resection, were analyzed. The new categories of N descriptor were created as follows: 1) NLN - median number of metastatic nodes was 3, thus in NLN0 the number of metastatic nodes =0, in NLN1 1-2, in NLN2 ≥ 3, 2) RLN - median ratio (number of metastatic lymph nodes to all nodes removed) was 12.4 %, thus in RLN0 the ratio was 0, in RLN1 | 13 %, in RLN2 | 13 %. The prognostic value of each classification was calculated on the basis of hazard ratios defined in multivariate Cox proportional hazard model. The new classifications of N descriptor turned out to be an independent strong prognostic factor (p |0.001) with a 5-year survival rate NLN0-62 %, NLN1-39 %, NLN2-26 % and RLN0-62 %, RLN1-37 % and RLN2
Systemic inflammation has long been related with adverse survival outcomes in cancer patients, and its biomarkers, such as the Neutrophil-to-Lymphocyte Ratio (NLR), are recognized as poor prognostic indicators. However, the role of eosinophils in this field has been largely overlooked. Here, we describe two new pre-treatment biomarkers, expressed as Eosinophil-to-Lymphocytes Ratio (ELR) and Eosinophil*Neutrophil-to-Lymphocytes ratio (ENLR), and we analyse their impact on prognosis of endometrial cancer (EC) patients. A total of 163 consecutive patients diagnosed with EC and treated with postoperative radiotherapy +/− chemotherapy in our institution from January 2011 to December 2015 were evaluated. The cohort was divided in two groups applying the cut-off value of 0.1 and 0.5 according to ROC curve for pre-treatment ELR and ENLR, respectively. After patients stratification according to the ESMO-ESGO-ESTRO modified risk assessment, subgroup analyses were conducted. Higher values of ELR and ENLR were
At present, TNM staging is considered the primary predictor of prognosis. However, this predictor has its limitation because patients at the same TNM stage may have a different prognosis. The introduction of laboratory indexes as additional factors is important for the accurate prediction of prognosis.. Recently, a growing body of evidence suggests that inflammatory biomarkers are associated with clinicopathological features and prognosis in patients with CRC. Accordingly, our results showed that LMR, NLR, PLR, PNI were associated with tumor size, tumor depth, and TNM stage. The results of Kaplan-Meier survival analysis with log-rank tests indicated that these inflammatory biomarkers were significantly associated with prognosis in CRC. However, the actual mechanisms of the association between these inflammatory biomarkers and prognosis in CRC are unclear. There are several potential explanations. First, neutrophils, monocytes, and platelets have been reported to promote tumor development via ...
The main findings of this study are the following: 1) CTA shows a better prognostic performance compared with ex-ECG; 2) evaluation of coronary anatomy with CTA may be the first diagnostic tool needed for prognostic stratification of patients with a low to intermediate pre-test likelihood of CAD, whereas ex-ECG may be more appropriate for further prognostic stratification in the subset of patients with CAD ≥50% on CTA; and 3) positive CTA findings identify a shorter event-free survival time regardless of the presence of ischemia at ex-ECG.. In the management of patients with suspected CAD, the prognostic stratification plays a crucial role beyond the simple diagnosis of coronary artery stenoses. Indeed, the occurrence of adverse events determines morbidity and mortality and influences the overall health expenditure. Until few years ago, diagnosis and prognostic evaluation of patients with suspected CAD were made with functional stress tests only in the majority of patients. Nowadays, ex-ECG is ...
The current study demonstrated that DFI, metastasis to vital organs, and absence of treatment for the first recurrence in the first relapse were prognosticators for SFFR among patients who died of breast cancer. Our findings about the important prognostic factors for SFFR are similar to other studies [10-15]. In earlier report by Clark et al. [10], initial site of recurrence, DFI, estrogen receptor of tumor, and axillary lymph nodes status at the time of initial diagnosis were determinant for survival from the time of first recurrence. Meanwhile, Vogel et al. [11] showed that DFI, dominant metastasis to visceral organ, and estrogen receptor status were prognostic factors for survival after first relapse. Besides the aforementioned factors, recent reports also have found human epidermal growth factor receptor 2 (HER2) status of tumor, and administration of certain treatment, including trastuzumab or aromatase inhibitors, as prognostic factors for SFFR [14,16]. The current and other reports have ...
BACKGROUND: Several prognostic indices have been devised to optimize patient selection for phase 1 oncology trials with no consensus as to the optimal score and none qualifying as a marker of treatment response. METHODS: Multivariate predictors of overall survival (OS) were tested on 118 referred patients to develop the Hammersmith Score (HS). The scores ability to predict OS, progression-free survival (PFS), and 90-day mortality (90DM) was compared with other prognostic indices. Changes in HS were recalculated during treatment. RESULTS: Albumin|35 g/L, lactate dehydrogenase|450 U/L, and sodium|135 mmol/L emerged as independent prognostic factors. These were used with equal weighting to devise the HS, a compound prognostic index ranging from 0 to 3. High (HS=2-3) score predicted worse OS (hazard ratio [HR]=6.5, P|.001), PFS (HR=2.8, P=.01), and 90DM (OR=9.0, P|.001). HS was a more accurate multivariate predictor of OS (HR=6.4, P|.001, C-index=0.72), PFS (HR=2.7, P=.03), and 90DM (area under the ROC
Christopher Plass and colleagues find thatOLIG1 expression correlates with survival in lung cancer patients and suggest that it could be used in deciding which patients are likely to benefit from more aggressive therapy.
In this study, doctors from England evaluated baseline prognostic factors in patients with locally advanced or metastatic esophago-gastric cancer. They also assessed whether pretreatment quality of life predicted survival.. The team studied 1080 patients were enrolled in 3 randomized, controlled trials which assessed fluorouracil-based combination chemotherapy, between 1992 and 2001. All patients completed the European Organization for Research and Treatment of Cancer core quality of life questionnaire before randomization. The team found that of the 1080 patients, 91% died. They identified 4 independent poor prognostic factors using multivariate analysis. These were performance status ≤2 (hazard ratio 1.58), liver metastases (HR 1.41), peritoneal metastases (HR 1.33), and alkaline phosphatase ≤100 U/L (HR, 1.41).. The team also constructed a prognostic index which divided patients into good (no risk factor), moderate (1 or 2 risk factors) or poor (3 or 4 risk factors) risk groups. The team ...
A novel finding with potential prognostic impact relates to the observation that 45/149 (30%) of M-CLL cases exhibited high expression of UGT2B17 and displayed poor clinical outcome (P,0.001, Online Supplementary Figure S1). Since the majority of these cases were negative for CD38 expression (134/149, 90%), carried only favorable genomic lesions (del(13q) or no recurrent aberrations (133/145, 92%) and did not display mutations in TP53 (145/149, 97%), NOTCH1 (139/142, 98%) or SF3B1 (140/143, 98%), quantification of UGT2B17 mRNA expression identified a subgroup of progressive M-CLL cases (31/120, 26%) for which, to date, no established prognostic marker has been successful in identifying (Figure 1C). Notably, within M-CLL, high UGT2B17 expression remained as the strongest independent molecular prognostic marker for OS in multivariate analysis (Online Supplementary Table S2). Further evaluation of UGT2B17 expression on clinical outcome in subgroups of CLL with favorable prognosis revealed high ...
BACKGROUND: Mucosal melanoma (MM) is a rare but diverse cancer entity. Prognostic factors are not well established for Caucasians with MM. PATIENTS AND METHODS: We analysed the disease course of 444 patients from 15 German skin cancer centres. Disease progression was determined with the cumulative incidence function. Survival times were estimated with the Kaplan-Meier method. Prognostic parameters were identified with multivariate Cox regression analysis. RESULTS: Common anatomic sites of primary tumours were head and neck (MMHN, 37.2%), female genital tract (MMFG, 30.4%) and anorectal region (MMAN, 21.8%). MMAN patients showed the highest vertical tumour thickness (p = 0.001), had a more advanced nodal status (p = 0.014) and a higher percentage of metastatic disease (p = 0.001) at diagnosis. Mutations of NRAS (13.8%), KIT (8.6%) and BRAF (6.4%) were evenly distributed across all tumour site groups. Local relapses were observed in 32.4% and most commonly occurred in the MMHN group (p = 0.016). ...
Study of Her2/Neu Expression in Breast Carcinoma and Correlation with Various Prognostic Parameters-IJPO-Print ISSN No:-2394-6784 Online ISSN No:-2394-6792Article DOI No:-10.18231,Indian Journal of Pathology and Oncology-IP Innovative Publication Pvt Limited, Medical Journals Publication, Open Access Journals, Print
We aimed to assess whether high-dose preoperative chemoradiotherapy (CRT) improves outcome in esophageal cancer patients compared to surgery alone and to define possible prognostic factors for overall survival. Hundred-and-seven patients with disease stage IIA - III were treated with either surgery alone (n = 45) or high-dose preoperative CRT (n = 62). The data were collected retrospectively. Sixty-seven patients had adenocarcinomas, 39 squamous cell carcinomas and one undifferentiated carcinoma. CRT was given as three intensive chemotherapy courses by cisplatin 100 mg/m2 on day 1 and 5-fluorouracil 1000 mg/m2/day, from day 1 through day 5 as continuous infusion. One course was given every 21 days. The last two courses were given concurrent with high-dose radiotherapy, 2 Gy/fraction and a median dose of 66 Gy. Kaplan-Meier survival analysis with log rank test was used to obtain survival data and Cox Regression multivariate analysis was used to define prognostic factors for overall survival. Toxicity
Population‑based study for predicting the prognosis for breast cancer liver metastasis (BCLM) is lacking at present. Therefore, the present study aimed to evaluate newly diagnosed BCLM patients of different tumor subtypes and assess potential prognostic factors for predicting the survival for BCLM patients. Specifically, data were collected from the Surveillance, Epidemiology and End Results program from 2010 to 2014, and were assessed, including the data of patients with BCLM. Differences in the overall survival (OS) among patients was compared via Kaplan‑Meier analysis. Other prognostic factors of OS were determined using the Cox proportional hazard model. In addition, the breast cancer‑specific mortality was assessed using the Fine and Grays competing risk model. A nomogram was also constructed on the basis of the Cox model for predicting the prognosis of BCLM cases. A total of 2,098 cases that had a median OS of 20.0 months were included. The distribution of tumor subtypes was as ...
The prognostic or predictive role of p53 mutations has remained controversial. Inconsistent associations have been reported between the overexpression of mutant p53 and patient outcome or tumor response to therapy.13,29 A recent meta-analysis suggested that p53 expression is not a significant prognostic marker for human astrocytomas (P = .531, hazard ratio = 1.034).8 Most interesting, the same results were demonstrated in this study. There are 2 possible explanations for this. First, it could be that p53 status has no significant impact on survival prognosis. Second, p53 could interact with a multitude of other factors to influence prognosis.. In the current study, the shortest PFS was identified in patients with mutant p53 tumors localized to VLSM-identified regions when cohorts were subdivided according to tumor location and p53 status. This finding suggests that mutant p53 has a significant influence on the prognosis of tumors involving VLSM-identified regions rather than other regions. ...
The decision to ask about your prognosis is a personal one. Its up to you to decide how much you want to know. Some people find it easier to cope and plan ahead when they know their prognosis and the statistics for how well a treatment might work. Other people find statistics confusing and frightening. Or they might think statistics are too general to be useful. A doctor who is most familiar with your health is in the best position to discuss your prognosis with you and explain what the statistics may mean in your case. At the same time, you should keep in mind that your prognosis can change. Cancer and cancer treatment outcomes are hard to predict. For instance, a favorable prognosis (which means youre likely going to do well) can change if the cancer keeps growing or doesnt respond to treatment. An unfavorable prognosis can change, too. This can happen if treatment controls the AML so it doesnt grow more. ...
Purpose: Previous results from the TransATAC study demonstrated that both the Breast Cancer Index (BCI) and the OncotypeDX Recurrence Score (RS) added significant prognostic information to clinicopathologic factors over a 10-year period. Here, we examined cross-stratification between BCI and RS to directly compare their prognostic accuracy at the individual patient level.. Experimental Design: A total of 665 patients with hormone receptor-positive (HR+) and lymph node-negative disease were included in this retrospective analysis. BCI and RS risk groups were determined using predefined clinical cut-off points. Kaplan-Meier estimates of 10-year risk of distant recurrence (DR) and log-rank tests were used to examine cross-stratification between BCI and RS.. Results: As previously reported, both RS and BCI were significantly prognostic in years 0 to 10. BCI provided significant additional prognostic information to the Clinical Treatment Score (CTS) plus RS (ΔLR-χ2 = 11.09; P , 0.001), whereas no ...
Yes‑associated protein (YAP) is a transcription‑coupling factor that plays a central role in the Hippo pathway, and its activation regulates cell proliferation and carcinogenesis. YAP activation has been reported in various malignancies, conferring tumors with migratory and invasive abilities. Several studies have suggested that YAP expression is closely associated with prostate cancer. Furthermore, YAP has been revealed to regulate destabilization of F‑actin associated with the cytoskeleton via Rho GTPase‑activating protein 29 (ARHGAP29), suggesting that ARHGAP29 is associated with cancer metastasis. In the present study, the functions of ARHGAP29 were examined in four prostate cancer cell lines (22Rv1, LNCaP, DU145 and PC‑3) and it was revealed that upregulation of ARHGAP29 in LNCaP and DU145 cells with the lowest expression of ARHGAP29 promoted cell proliferation and invasion. Conversely, ARHGAP29 knockdown in PC‑3 cells with its highest expression level significantly reduced cell ...
Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLRvalues were 8.3 and 6.2 months respectively in patients with NLR |3.34 (pstudy showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.
The introduction of novel agents in the clinical management of MM has led to the need for new risk predictors and although cytogenetic abnormalities represent strong prognostic factors, their real role in risk prediction is still a matter of debate.. Del(13), del(17p), IGH translocations and high-risk chromosomal abnormalities did not show a significant impact on overall survival or progression-free survival of patients enrolled in the VMP versus VMPT-VT trial. This finding confirms and emphasizes the already reported beneficial role of bortezomib, which seems to overcome the negative impact of poor prognostic cytogenetic features.29,31,33 This was demonstrated not just in the study by Palumbo et al.,31 but also in the bortezomib-based trial by Harousseau et al.,34 which showed a similar progression-free survival between cytogenetically defined high-risk and standard-risk patients. Moreover, the Spanish VISTA trial35, comparing MP and VMP, showed that, in the VMP subgroup, there was no ...
An approach to molecular classification based on the comparative expression of protein pairs is presented. The method overcomes some of the present limitations in using peptide intensity data for class prediction for problems such as the detection of a disease, disease prognosis, or for predicting treatment response. Data analysis is particularly challenging in these situations due to sample size (typically tens) being much smaller than the large number of peptides (typically thousands). Methods based upon high dimensional statistical models, machine learning or other complex classifiers generate decisions which may be very accurate but can be complex and difficult to interpret in simple or biologically meaningful terms. A classification scheme, called ProtPair, is presented that generates simple decision rules leading to accurate classification which is based on measurement of very few proteins and requires only relative expression values, providing specific targeted hypotheses suitable for
The median numbers of involved and dissected LN were 5 (0-50), and and 21 (2-91), respectively. The median follow-up period was 36.7 months. In multivariate analysis, LODDS system was independent prognostic factor for GC mortality (HR:2.02, 95%CI 1.61-2.54; p< 0.0001) and recurrence (HR:2.02 95%CI 1.47-2.77; p< 0.0001). LODDS system significantly discriminated the prognostic groups in patients with 6 to ≤ 10 LN retrieved (plog-rank = 0.022) and 11 to < 15 LN retrieved (plog-rank = 0.014) whereas pN or LNR classifications did not. In patients with ≤ 5 LN retrieved, the prediction of prognosis was insignificant for all 3 staging systems (plog-rank> 0.05). LODDS system also significantly discriminated the prognostic groups both in the patients with D1 and D2 lymphadenectomy, as well as in patients who received adjuvant chemotherapy and radiotherapy. ...
In the population of 129 patients, the only significant correlation between age and clinical-pathological features is between advanced age (,80yr) and tumor location in the right colon (53.7%, p=0.04).. Risk of relapse is related both to depth of tumor invasion (42.9% in stage T4, 6.3% in stage T1, p=0.01) and advanced age (19.5% in ,80yr, 4% in ,65yr).. Overall survival (OS) and disease free survival (DFS) are significantly lower in patients aged over 80 than the other two classes. This significance is maintained by stratifying the 129 patients in the two age classes (,70, ,70).. In the multivariate analysis age , 80yr is significantly correlated with an increased risk of relapse.. Evaluating the control group no significant correlation between relapse and clinical-pathological features was detected.. In the multivariate analysis in stage II population, advanced age doesnt play any significant prognostic role in the risk of recurrence, while a reduction in DFS is related to depth of tumor ...
This page contains the ABSTRACT- Accurate Prognosis in Personal-Injury Cases Using Georges Line http://www.chiro.org/radiology/ABSTRACTS/Accurate_Prognosis.shtml
Exercise and prognosis on the basis of clinicopathologic and molecular features in early-stage breast cancer: The LACE and pathways studies Academic Article ...
Anal cancer treatment options include radiation therapy, chemotherapy, and/or surgery. Major prognostic factors are site, size, and nodal status. Get detailed information about newly diagnosed and recurrent anal cancer and treatment in this summary for clinicians.
Kawaguchi, T., Matsumura, A., et al., 2010. Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer: a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer, 5(7), pp.1001-1010 ...
Nonetheless, it occurs to me that it is a matter of definition; what do we mean by prognosis? For most of us, it means the likelihood of healing, rebuilding, or cure. A bad prognosis means there is little chance for recovery. Someone with a good or excellent prognosis is probably going to get better ...
Conference (2017, April 24). CAF-specific proteins can provide important prognostic markers and targets for anticancer drugs. Recently, integrin α11 (ITGA11) emerged as a new biomarker of CAFs. ITGA11 is mainly expressed by ... [more ▼]. CAF-specific proteins can provide important prognostic markers and targets for anticancer drugs. Recently, integrin α11 (ITGA11) emerged as a new biomarker of CAFs. ITGA11 is mainly expressed by mesenchymal cells and is correlated with fibroblast activation and matrix reorganization. While the role of ITGA11 in wound healing has been well described, only a very limited number of reports have assessed its role in the cancer disease. This research project aims to investigate the role of stromal ITGA11 in breast cancer. To analyze the in vivo effects of ITGA11 on tumor insurgence, growth and metastasis, we crossed the oncogenic MMTv-PyMT mice with the ITGA11 KO/WT mice, which develop spontaneously breast tumors. ITGA11 deletion strongly delayed tumor growth and ...
BACKGROUND: The system to allocate scarce transplantable livers has been criticized for not giving enough weight to the prognoses of the patients receiving the transplants, but little research has been done looking at how the public weights the relative importances of efficacy and equity in distributing the organs. METHODS: This study was an experimental survey of prospective jurors asked to distribute transplantable livers among transplant candidates grouped according to their prognoses. The relative prognoses of the transplant candidates were varied across survey versions. RESULTS: As the prognostic difference between transplant groups increased, the subjects became less likely to distribute the organs equally between them (p less than 0.005). However, the subjects willingness to base allocation on prognosis was moderated by a number of factors, including their understanding of how to use prognostic information and their attitudes toward using prognostic information for individuals versus ...
TY - JOUR. T1 - Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin. AU - Yu, Ming Chin. AU - Lee, Yun Shien. AU - Lin, Sey-En. AU - Wu, Hsiang Yao. AU - Chen, Tse Ching. AU - Lee, Wei Chen. AU - Chen, Miin Fu. AU - Tsai, Chi Neu. PY - 2012/7/1. Y1 - 2012/7/1. N2 - Background: Early detection and following appropriate treatments of hepatocellular carcinoma (HCC) is still the gold standard for favored outcome of HCC patients; nevertheless, a small portion of hepatitis B virus (HBV)-related small HCC (,5 cm) patients got poor prognosis. Furthermore, the study for small HBV-HCC was limited. Therefore, the aim of this study was to explore the potential genetic signature for HBV-related small HCC as novel prognostic factors. Methods: We examined expression profiles of HBV-related small HCC using an Affymetrix U133A GeneChip, evaluated differential gene ...
TY - JOUR. T1 - Vascular invasion is a strong prognostic factor after complete resection of node-negative non-small cell lung cancer. AU - Naito, Yoichi. AU - Goto, Koichi. AU - Nagai, Kanji. AU - Ishii, Genichiro. AU - Nishimura, Mitsuyo. AU - Yoshida, Junji. AU - Hishida, Tomoyuki. AU - Nishiwaki, Yutaka. N1 - Funding Information: Funding/Support: This study was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour, and Welfare of Japan. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Background: The seventh edition of TNM classification for non-small cell lung cancer (NSCLC) has been approved. Vascular invasion has been reported as being a strong risk factor; therefore, we reviewed the impact of vascular invasion on new TNM classification. Methods: We reviewed patients with completely resected NSCLC without lymph node metastasis treated at our institute between January 1993 and December 2003. Vascular ...
Article: Improved prognosis following renin-angiotensin-aldosterone system blockade in patients undergoing concomitant aortic and mitral valve ...
Alcoholism prognosis statistics Alcoholism prognosis scale Chronic alcoholism prognosis Neuropathy alcoholism prognosis Bipolar alcoholism prognosis Alcoholism recovery prognosis Peripheral neuropathy alcoholism prognosis End stage alcoholism prognosis Li ➥ PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health ➤ Alcoholism prognosis statistics Alcoholism prognosis scale Chronic alcoholism prognosis Neuropathy alcoholism prognosis Bipolar alcoholism prognosis Alcoholism recovery prognosis Peripheral neuropathy alcoholism prognosis End stage alcoholism prognosis Li on the site ➦ alcohol-ism.info
Alcoholism prognosis statistics Alcoholism prognosis scale Chronic alcoholism prognosis Neuropathy alcoholism prognosis Bipolar alcoholism prognosis Alcoholism recovery prognosis Peripheral neuropathy alcoholism prognosis End stage alcoholism prognosis Li ➥ Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice. ➤ Alcoholism prognosis statistics Alcoholism prognosis scale Chronic alcoholism prognosis Neuropathy alcoholism prognosis Bipolar alcoholism prognosis Alcoholism recovery prognosis Peripheral neuropathy alcoholism prognosis End stage alcoholism prognosis Li on the site ➦ alcohol-ism.info
Cervical cancer is the second most common malignancy in women worldwide and one of the leading causes of cancer mortality globally. In patients with invasive cervical cancer prognostic factors are of value for the choice of treatment, monitoring of treatment and follow-up. The most important clinical prognostic factors are stage, tumor volume, parametrial infiltration, vascular invasion, lymph node metastases, and distant metastases. An improved estimation of the prognosis of cervical cancer is desirable, especially in early cancer stages.. The aim of this research was to study possible associations between tumor markers, female sex steroids, smoking, S-phase fraction (SPF), and prognosis in invasive squamous cell cervical cancer (SCC). The study comprised 190 patients with SCC, stages IB-IV, admitted to the Department of Gynecologic Oncology at Norrland University Hospital in Umeå between September 1984 and October1990. Ten year mortality was estimated.. In study I, of a total of 103 patients, ...
TY - JOUR. T1 - Allogeneic transplantation for recurrent or refractory non-Hodgkins lymphoma with poor prognostic features after conditioning with thiotepa, busulfan, and cyclophosphamide. T2 - Experience in 44 consecutive patients. AU - Van Besien, Koen. AU - Thall, Peter. AU - Korbling, Martin. AU - Pugh, William C.. AU - Khouri, Issa. AU - Mehra, Rakesh. AU - Giralt, Sergio. AU - Anderlini, Paolo. AU - Amin, Kamal. AU - Mirza, Nadeem. AU - Seong, David. AU - Gajewski, James. AU - Hester, Jeane. AU - Andersson, Borje. AU - Cabanillas, Fernando. AU - Champlin, Richard. AU - Przepiorka, Donna. PY - 1997/8/1. Y1 - 1997/8/1. N2 - We report the outcomes of 44 consecutive patients with non-Hodgkins lymphoma (NHL) who participated in prospective studies of allogeneic transplantation after conditioning with thiotepa, busulfan and cyclophosphamide. Within a range of 27-57 years, the median age was 37. Of the 44 patients, 12 (27.2%) had high-grade lymphomas, 27 (61.4%) had intermediate-grade ...
TY - JOUR. T1 - Diurnal and 24-h Intraocular Pressures in Glaucoma. T2 - Monitoring Strategies and Impact on Prognosis and Treatment. AU - Konstas, Anastasios G.. AU - Kahook, Malik Y.. AU - Araie, Makoto. AU - Katsanos, Andreas. AU - Quaranta, Luciano. AU - Rossetti, Luca. AU - Holló, Gábor. AU - Detorakis, Efstathios T.. AU - Oddone, Francesco. AU - Mikropoulos, Dimitrios G.. AU - Dutton, Gordon N.. PY - 2018/11/1. Y1 - 2018/11/1. N2 - The present review casts a critical eye on intraocular pressure (IOP) monitoring and its value in current and future glaucoma care. Crucially, IOP is not fixed, but varies considerably during the 24-h cycle and between one visit and another. Consequently, a single IOP measurement during so-called office hours is insufficient to characterize the real IOP pathology of a patient with glaucoma. To date IOP remains the principal and only modifiable risk factor for the development and progression of glaucoma. Only by evaluating IOP characteristics (mean, peak and ...
Hepatocellular carcinoma (HCC) remains a major challenge for public health worldwide. Considering the great heterogeneity of HCC, more accurate prognostic models are urgently needed. To identify a robust prognostic gene signature, we conduct this study. Level 3 mRNA expression profiles and clinicopathological data were obtained in The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC). GSE14520 dataset from the gene expression omnibus (GEO) database was downloaded to further validate the results in TCGA. Differentially expressed mRNAs between HCC and normal tissue were investigated. Univariate Cox regression analysis and lasso Cox regression model were performed to identify and construct the prognostic gene signature. Time-dependent receiver operating characteristic (ROC), Kaplan-Meier curve, multivariate Cox regression analysis, nomogram, and decision curve analysis (DCA) were used to assess the prognostic capacity of the six-gene signature. The prognostic value of the gene signature was
TY - JOUR. T1 - Tumour biomarkers. T2 - homeostasis as a novel prognostic indicator. AU - Falco, Michela. AU - Palma, Giuseppe. AU - Rea, Domenica. AU - De Biase, Davide. AU - Scala, Stefania. AU - DAiuto, Massimiliano. AU - Facchini, Gaetano. AU - Perdonà, Sisto. AU - Barbieri, Antonio. AU - Arra, Claudio. N1 - © 2016 The Authors.. PY - 2016/12. Y1 - 2016/12. N2 - The term personalized medicine refers to a medical procedure that consists in the grouping of patients based on their predicted individual response to therapy or risk of disease. In oncologic patients, a tailored therapeutic approach may potentially improve their survival and well-being by not only reducing the tumour, but also enhancing therapeutic response and minimizing the adverse effects. Diagnostic tests are often used to select appropriate and optimal therapies that rely both on patient genome and other molecular/cellular analysis. Several studies have shown that lifestyle and environmental factors can influence the ...
BACKGROUND: A randomised trial published by the European Organisation for Research and Treatment of Cancer (EORTC) and the National Cancer Institute of Canada (NCIC) Clinical Trials Group (trial 26981-22981/CE.3) showed that addition of temozolomide to radiotherapy in the treatment of patients with newly diagnosed glioblastoma significantly improved survival. We aimed to undertake an exploratory subanalysis of the EORTC and NCIC data to confirm or identify new prognostic factors for survival in adult patients with glioblastoma, derive nomograms that predict an individual patients prognosis, and suggest stratification factors for future trials. METHODS: Data from 573 patients with newly diagnosed glioblastoma who were randomly assigned to radiotherapy alone or to the same radiotherapy plus temozolomide in the EORTC and NCIC trial were included in this subanalysis. Survival modelling was done in three patient populations: intention-to-treat population of all randomised patients (populat
In this study, we found that p16 expression status in the tissue of patients with oropharyngeal cancer is a strong independent prognostic factor for local recurrence as well as disease-free and overall survival. Patients with p16-nonoverexpressing tumors had a 6-fold increase in risk of local recurrence and an almost 3-fold increase in risk of death from any cause. In multivariate analysis, p16 expression status remained an independent prognostic factor. This result is striking, given that p16 overexpression was also associated with poor prognostic features such as advanced TNM stage and high histologic grade.. The relationship between p16 expression levels and prognosis is controversial. Loss of p16 expression has been found to be associated with worse prognosis in several cancers, including non-small cell lung cancer, melanoma, nasopharyngeal, hepatocellular, and colorectal carcinoma (15 , 20, 21, 22, 23, 24) . This is in contrast to reports that overexpression of p16 is associated with poor ...
TY - JOUR. T1 - Update on prognostic markers for endometrial cancer. AU - Binder, Pratibha S.. AU - Mutch, David G.. PY - 2014/5. Y1 - 2014/5. N2 - Endometrial cancer is the most common gynecologic cancer in the USA and the second most common worldwide after cervical cancer. While common symptomatology of endometrial cancer leads to early diagnosis and favorable 5-year survival in most cases, there is a subset of cancers that have a poorer prognosis. The clinical and pathologic prognostic factors for endometrial cancer are well known and instrumental in determining the need for adjuvant therapy. Recently, research has been focused on the identification of molecular changes leading to different histologic subtypes to improve classification of endometrial cancer. The identification of novel mutations and molecular profiles should enhance our ability to personalize adjuvant treatment with genome-guided targeted therapy.. AB - Endometrial cancer is the most common gynecologic cancer in the USA and ...
Circulating microRNA (miRNA) has recently emerged as a promising biomarker for myocardial infarction. Apoptotic cardiomyocytes release miRNA into the circulation and the detection of cardiospecific miRNA species in the blood might constitute a rapid and robust diagnostic tool with high specificity. However, the studies conducted thus far have been based on small clinical materials and have exclusively looked at the acute phase of myocardial infarction (MI). We wanted to assess the usefulness of circulating miRNA both for distinguishing between MI and non-MI in the acute phase and for long term prognosis of death and development of heart failure in a larger population of acute coronary syndromes (ACS). All patients presenting with suspected ACS pain in the coronary care unit at Lund University Hospital were offered to take part in the study. Levels of cardiospecific miRNAs miR-1, miR-208b and miR-499 were measured in plasma of 430 patients by quantitative real time PCR. Receiver operator ...
The present study demonstrates that IGFBP‐4 fragments are associated with an increased risk of all‐cause mortality, cardiovascular mortality, and MACE in a cohort of patients with STEMI. The associations were significant both at 3 months and 5 years after the STEMI. Nevertheless, an association alone is insufficient to establish prognostic value, and the use of IGFBP‐4 fragments to determine the risk of a future event as a continuous variable demands cautious consideration. Various risk scores and statistical tests in the cardiovascular area have generated considerable controversy, and no clear consensus has been established. In this study, the incremental prognostic value of the addition of the IGFBP‐4 fragments to the clinical model was assessed by discrimination, calibration, and reclassification analyses. Discrimination and calibration analyses indicated that models including either NT‐ or CT‐IGFBP‐4 were more accurate than the clinical model alone. To assess the magnitude of ...
The identification of a prognostic gene expression signature in breast cancer that is valid across multiple independent data sets and different microarray platforms is a challenging problem [1]. Recently, there have been reports of molecular prognostic and predictive signatures that were also valid in external independent cohorts [2-7]. One of these studies derived the prognostic signature from genes correlating with histological grade [4], while in [5] it was derived directly from correlations with clinical outcome data and was validated in estrogen receptor positive lymph node negative (ER+LN-) breast cancer. Another study validated a predictive score, based on 21 genes, for ER+LN-tamoxifen treated breast cancer [2]. These results are encouraging, yet, as explained recently in [8, 9], much larger cohort sizes may be needed before a consensus prognostic signature emerges. While the intrinsic subtype classification does appear to constitute a set of consensus signatures [7], it is also clear ...
Surgery is the mainstay curative treatment in most cancer. We aimed to test the new hypothesis that cancer surgery performed during holiday periods is associated with worse long-term prognosis than for non-holiday periods. This nationwide Swedish population-based cohort study included 228,927 patients during 1997-2014 who underwent elective resectional surgery for a cancer where the annual number of resections was over 100. The 16 eligible cancer sites were grouped into 10 cancer groups. The exposure, holiday periods, was classified as wide (14-weeks) or narrow (7-weeks). Surgery conducted inside versus outside holiday periods was compared regarding overall disease-specific (main outcome) and overall all-cause (secondary outcome) mortality. Cox regression provided hazard ratios (HR) with 95% confidence intervals (CI) adjusted for age, sex, comorbidity, hospital volume, calendar period and tumor stage. Surgery conducted during wide and narrow holiday periods were associated with increased HRs of ...
Materials and Methods We carried out a retrospective multivariate analysis of 713 patients with ALS over a 20 year period from the South-East England Amyotrophic Lateral Sclerosis (SEALS) population register. Patients were randomly allocated to discovery or test cohorts. A prognostic score was calculated using the discovery cohort and then used to predict survival in the test cohort. This score was used as a predictor variable in subsequent survival analyses, either as a raw value for a Cox regression or split into four prognostic categories (good, moderate, average, poor).. ...
The TNM staging system is an internationally standardized system for the staging of cancer and is in its seventh decade of continuing formulation. The TNM classification is put forth by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC; http://www.uicc.org). The AJCCs Cancer Staging Manual and the UICCs TNM Classification of Malignant Tumours present the stages of cancer as defined by TNM classifications. The TNM definitions and stage groupings are based on prognostic outcome. Information about TNM may be accessed at the UICC website, http://www.uicc.org/index.php?id=508. The TNM symbols follow. ▪ T: tumor (indicates size, extent,
The TNM staging system is an internationally standardized system for the staging of cancer and is in its seventh decade of continuing formulation. The TNM classification is put forth by the American Joint Committee on Cancer (AJCC) and the International Union Against Cancer (UICC; http://www.uicc.org). The AJCCs Cancer Staging Manual and the UICCs TNM Classification of Malignant Tumours present the stages of cancer as defined by TNM classifications. The TNM definitions and stage groupings are based on prognostic outcome. Information about TNM may be accessed at the UICC website, http://www.uicc.org/index.php?id=508. The TNM symbols follow. ▪ T: tumor (indicates size, extent,
article{41e2a13a-ee9a-4633-bac9-189ca386b82d, abstract = {FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPLs prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemistry (IHC). In a meta-analysis, FKBPL levels were a significant predictor of BCSS; low FKBPL levels indicated poorer breast cancer specific survival (BCSS) (hazard ratio (HR) = 1.30, 95% confidence interval (CI) 1.14-1.49, p < 0.001). The prognostic impact of FKBPL remained significant after adjusting for other known prognostic factors (HR = 1.25, 95% CI 1.07-1.45, p = 0.004). For the sub-groups of 2365 estrogen receptor (ER) positive patients and 1649 tamoxifen treated patients, FKBPL was significantly associated with BCSS (HR = 1.34, 95% CI ...
Bcl-2 and p53 gene products (Bcl-2, p53) are important regulators of apoptosis and cell proliferation, and their immunohistochemical expression may help to identify high-risk breast cancer patients. The authors evaluated p53 and Bcl-2 immunoreactivity in 178 node-negative breast cancers (NNBC) with long-term follow-up (median, 60 months). Bcl-2 was seen in 111 (62%) cases, and was significantly associated with small tumor size, nonductal morphology, low tumor grade, estrogen-receptor (ER) positivity, and p53 negativity. p53 overexpression (ie, | 15% reactive nuclei) was observed in 31 (17%) cases, and was associated with lower age, large tumor size, ductal morphology, high tumor grade, negative ER status, and lack of Bcl-2 immunoreactivity. In univariate analysis, the variables associated with short relapse-free survival (RFS) were large tumor size (P = .002), high histological grade (P = .01), high mitotic count (P = .03), and high Nottingham prognostic index (NPI) (P = .0002). In multivariate analysis
Neuroendocrine tumours(NETs) are heterogeneous with respect to biological behavior. Consequently, prognosis is variable and biomarkers predicting survival or tumour progression are required to inform clinical management. The best available biomarker, histological grade, is assigned using Ki-67 or mitotic count. Agreement between these two indices is implied but analysis of 131 pancreatic and 136 midgut NETs suggested discordances of 44% and 38% respectively. Ki-67 was the superior prognostic marker, making the additional value of mitotic count questionable. Detection of Circulating Tumour Cells(CTCs) using the Cellsearch™ platform requires expression of epithelial cell adhesion molecule(EpCAM). I demonstrated EpCAM expression by immunohistochemistry and detected CTCs in patients with metastatic NETs. In 175 patients, ≥1 CTC was detected in 51%(midgut) and 36%(pancreatic). ≥1 CTC was an independent poor prognostic factor, offering better prognostic value than grade or chromogranin A(CgA). ...
Bacterial meningitis (BM) is a severe infection responsible for high mortality and disabling sequelae. Early identification of patients at high risk of these outcomes is necessary to prevent their occurrence by adequate treatment as much as possible. For this reason, several prognostic models have been developed. The objective of this study is to summarize the evidence regarding prognostic factors predicting death or sequelae due to BM in children 0-18 years of age. A search in MEDLINE and EMBASE was conducted to identify prognostic studies on risk factors for mortality and sequelae after BM in children. Selection of abstracts, full-text articles and assessment of methodological quality using the QUIPS checklist was performed by two reviewers independently. Data on prognostic factors per outcome were summarized. Of the 31 studies identified, 15 were of moderate to high quality. Due to substantial heterogeneity in study characteristics and evaluated prognostic factors, no quantitative analysis was
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The present thesis is focused on the prognostic value of genetic variations and alterations in the initiation and development of chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) patients. Several prognostic markers based on genetic or chromosomal aberrations are today used in clinic in these heterogeneous diseases. Novel biomarkers have been identified through next generation sequencing techniques and some of them may be useful as prognostic markers in clinical diagnostic. In papers I-IV we have investigated some of this markers in CLL and AML tumor cells.. In papers I and III we investigated the prognostic value of the MDM2 SNP309 in relation to the presence of TP53 mutations in tumor cells from CLL and AML patients. The SNP309 G-allele was associated with a shorter overall survival in TP53 wildtype CLL and non-normal karyotype AML patients. Mutations in the TP53 gene were found in 6.2% in CLL and 21.7% in AML and were always associated with adverse overall survival. This was ...
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in human breast cancer cell lines. In the current study, alterations of the gene in 189 primary human breast cancers were investigated. HER-2/neu was found to be amplified from 2- to greater than 20-fold in 30% of the tumors. Correlation of gene amplification with several disease parameters was evaluated. Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer. It retained its significance even when adjustments were made for other known prognostic factors. Moreover, HER-2/neu amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of ...
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth factor receptor. This gene has been shown to be amplified in human breast cancer cell lines. In the current study, alterations of the gene in 189 primary human breast cancers were investigated. HER-2/neu was found to be amplified from 2- to greater than 20-fold in 30% of the tumors. Correlation of gene amplification with several disease parameters was evaluated. Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer. It retained its significance even when adjustments were made for other known prognostic factors. Moreover, HER-2/neu amplification had greater prognostic value than most currently used prognostic factors, including hormonal-receptor status, in lymph node-positive disease. These data indicate that this gene may play a role in the biologic behavior and/or pathogenesis of ...
The investigators initially created the GPA after studying the files of 1,980 patients from four prospective randomized Radiation Therapy Oncology Group (RTOG) clinical trials. They have recently expanded to 11 centers that pulled together records from 3,940 patients with newly diagnosed brain metastases, all of whom had been treated. They matched up prognostic factors with different cancers and tumor subtypes and discovered that specific prognostic factors could be used for each of the cancers to help determine a prognosis. A score of zero offers the worst prognosis.. They studied patients with small-cell lung cancer, non-small cell lung cancer, melanoma, breast cancer, renal cell carcinoma and gastrointestinal (GI) cancers. The overall median survival differed for each of the cancers and specific prognostic factors were stronger in determining survival. They went back into the medical records to look at the primary tumor type, the number of brain metastases, age at diagnosis, the ...
Results An optimal 13-gene expression classifier (PIGR, CXCL13, MMP3, TUBA1B, SESN1, AZGP1, KLK6, EPHA7, SEMA3A, DSC3, CXCL10, ENPP3, BNIP3) for prediction of relapse among patients with stage II CRC was developed using a consecutive Norwegian test series from patients treated according to current standard protocols (n=44, p,0.001, HR=18.2), and its predictive value was successfully validated for patients with stage II CRC in a second Norwegian CRC series collected two decades previously (n=52, p=0.02, HR=3.6). Further validation of the classifier was obtained in a recent external dataset of patients with stage II CRC from other populations (n=108, p=0.001, HR=6.5). Multivariate Cox regression analyses, including all three sample series and various clinicopathological variables, confirmed the independent prognostic value of the classifier (p≤0.004). The classifier was shown to be specific to stage II CRC and does not provide prognostic stratification of patients with stage III CRC. ...
Minimal residual disease (MRD) can be an important predictor of relapse in acute lymphoblastic leukemia (ALL), but its relationship to additional prognostic variables has not been fully assessed. National Cancer Insitute high-risk (NCI HR) individuals who have been MRD+. The few individuals with detectable MRD at end of consolidation fared especially poorly, with only a 43% plus or minus 7% 5-yr EFS. Day time-29 marrow MRD was the most important prognostic variable in multi-variate analysis. The 12% of individuals with all beneficial risk factors, including NCI risk group, genetics, and absence of days 8 and 29 MRD, experienced a 97% plus or minus 1% 5-yr EFS with nonintensive therapy. These studies are authorized at www.clinicaltrials.gov because NCT00005585, NCT00005596, and NCT00005603. Intro The presence of minimal residual disease (MRD) following therapy for acute lymphoblastic leukemia (ALL) offers been shown to be an important prognostic marker in many studies.1C20 MRD is typically ...
0051] The term prognosis as used herein refers to a prediction of the probable course and outcome of a clinical condition or disease. A prognosis is usually made by evaluating factors or symptoms of a disease that are indicative of a favorable or unfavorable course or outcome of the disease. The phrase determining the prognosis as used herein refers to the process by which the skilled artisan can predict the course or outcome of a condition in a patient. The term prognosis does not refer to the ability to predict the course or outcome of a condition with 100% accuracy. Instead, the skilled artisan will understand that the term prognosis refers to an increased probability that a certain course or outcome will occur; that is, that a course or outcome is more likely to occur in a patient exhibiting a given condition, when compared to those individuals not exhibiting the condition. The terms favorable prognosis and positive prognosis, or unfavorable prognosis and negative prognosis ...
article{1efcb56d-fdcb-4628-a18a-906218d7c70d, abstract = {Background and Purpose-A low risk of recurrent stroke and death after lacunar infarction has previously been reported, but follow-up has been limited to less than or equal to5 years. Methods-One hundred eighty patients with pure motor stroke, collected between 1983 and 1986 from a hospital-based stroke registry, were followed up until at least 10 years after the index stroke. Two patients were lost to follow-up. Survival status was determined from the official population registry and compared with survival rates of the Swedish population, matched for age and sex. Cox proportional hazards regression analyses were used to identify independent prognostic predictors. Results-During follow-up 106 (60%) of the 178 patients died, most commonly as a result of coronary heart disease. During the first 5 years after the stroke, survival rates were similar to those of the general population. Beyond this time the risk of death was increased among ...
Another challenge in lung cancer is the difficulty in predicting the treatment response or prognosis. Gratifyingly, in addition to the reports by Aerts H discussed above, several studies have successfully developed radiomics prognostic classifiers for lung cancer patients treated with surgery, radiotherapy or targeted therapies. Eleven stable radiomics feature clusters extracted from the pretreatment CT images with lung cancer have been found to indicate a strong association with prognosis [44]. Local recurrence and distant metastasis are important prognostic factors in cancer patients. Therefore, developing efficient biomarkers to predict patients at high risk of local recurrence or distant metastasis may help to avoid intensive systemic therapy in these subgroups. Coraller TP et al. have constructed a radiomics model with 635 features. Thirty-five have been found to be predictive of metastasis, and 12 have been found to be predictive of survival. The predictive power of the radiomics ...
Eligibility Criteria. Patients must have histologically or cytologically confirmed Squamous Cell Cancer of the Head and Neck either (a) metastatic (i.e. American Joint Committee on Cancer Staging System, 6th edition, stage IVC) or (b) recurrent, judged incurable by surgery or radiation.. Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded) as ,20 mm with conventional techniques or as ,10 mm with CT scan). RECIST criteria will be used (see section 9).. Therapeutic history in conformance with the following:. No more than one prior adjuvant/neoadjuvant chemotherapy and/or concomitant chemoradiotherapy regimen that may have included biologic/targeted agent.. No more than one prior regimen (chemotherapy or biologic/targeted) for recurrent/metastatic disease. ECOG performance status of 0-2 (Karnofsky , 60%; see Appendix A).. Patients must have normal organ and marrow function as defined ...
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Hemoglobin is a known prognostic marker in many cancers, including head and neck cancer (HNC). There is some evidence that the red cell distribution width, which is an index of variation in size of red blood cells (RBCs), might be associated with prognosis as well. Recently, a novel prognostic biomarker has been reported-the ratio of the hemoglobin-to-red cell distribution width (Hb/RDW). Our objective was to evaluate the prognostic utility of the pretreatment Hb/RDW in HNC, controlled with known prognostic indices. Methods: Retrospective cohort study in a tertiary academic hospital setting. Patients diagnosed with HNC treated with curative-intent surgery were eligible. Metastatic disease was excluded. The variables collected were age, sex, BMI, alcohol/tobacco exposure, performance scores, ACE-27, tumor characteristics, adjuvant treatment, and lab values. The primary endpoints were event-free survival (EFS) and overall survival
For different types of tumors, we have investigated the correlation of the GPS with clinically relevant parameters. Using Cox regression models we demonstrated that the GPS is a medically relevant prognostic factor that can be used to discriminate between patient subgroups with different expected clinical outcome.. 1) We analyzed the prognostic value of the GPS for relapse of prostate cancer patients. Cox proportional hazard models were fitted to observed times until PSA (prostate specific antigen) relapse following radical prostatectomy. GPS was calculated from CGH (comparative genomic hybridization) measurements. For prostate cancer, the Gleason score reflecting the histological pattern of tumor growth is a common grading system with high predictive value. In practice, many tumors are scored with an average value of 7. Restricting to patients with such a score only, we showed that the GPS can be used to further identify subgroups with different prognosis. This shows that the GPS can improve ...
Background: The aim of this study was to estimate some prognostic factors that affect on overall survival ofpatients with early gastric cancer. Methods: A retrospective study had been done on patients diagnosed withearly gastric cancer who registered in cancer registry center, Tehran-Iran, between December 21, 2001 andDecember 21, 2006 and all patients were followed by telephone contacts. The Kaplan-Meier method was performedto describe survival curves and log-rank test to compare the survival rate in subgroups. Cox regression wasused to determine the prognosis factors. Results: The mean age was 57.9 ± 11.9 years and 72.6% of patientswere male. Tumor size (|35mm) and lymph node metastasis were established as significant factors for survivalof patients with EGC in both univariate and multivariate analysis. Conclusion: The findings of this studyindicate that lymph node metastasis and tumor size are the most independent prognostic factors in these patients.
Results The authors identified a gene signature that was associated with overall survival and disease-free survival in 177 patients and validated in two independent cohorts of 213 patients. In multivariate analysis, the signature was an independent risk factor (HR 3.08; 95% CI 1.33 to 7.14; p=0.008 for overall survival). Subset analysis of patients with AJCC (American Joint Committee on Cancer) stage III cancer revealed that the signature can also identify the patients who have better outcome with adjuvant chemotherapy (CTX). Adjuvant chemotherapy significantly affected disease-free survival in patients in subtype B (3-year rate, 71.2% (CTX) vs 41.9% (no CTX); p=0.004). However, such benefit of adjuvant chemotherapy was not significant for patients in subtype A. ...
Maspin, a member of the Serpin protease inhibitor family, is overexpressed in poorly differentiated colorectal tumors and more frequently found in tumors with microsatellite instability. Immunohistochemical nuclear Maspin staining is predominantly seen in tumor cells at the invasion front of such cancers, suggesting that this molecule is associated with local tumor cell infiltration and aggressiveness. In a retrospective study, we studied nuclear Maspin expression as a potential prognostic tool in a total of 172 primary stage III colon cancers by immunohistochemistry. Of those 172 patients, 76 were treated by surgery only, and 96 patients received additional adjuvant 5-fluorouracil (5-FU) based chemotherapy. Nuclear Maspin expression was an independent adverse prognostic factor for overall survival in our patient cohort (hazard ratio 2.08; 95% CI, 1.13-3.81; p = 0.018). However, patients with primary tumors expressing Maspin in the nucleus showed a significant treatment benefit from 5-FU ...
Although risk factors for poor prognosis in patients with IgAN have been reported previously [1, 2], it is still difficult to accurately estimate renal prognosis in these patients. Although serum levels of C3 and C4 frequently fluctuate within the normal range in IgAN patients, studies have increasingly focused on the role of complement in the pathogenesis of IgAN [14-17]. However, the relationship between serum complement levels and the renal prognosis of patients with IgAN remains controversial.. There were studies discussing the relationship between serum C3 levels and the prognosis of IgAN. Kim et al. reported that low serum C3 at the time of renal biopsy was an independent risk factor for poor prognosis [18]. Lbels et al. also found that higher serum C3 at the end of follow up were associated with adverse outcomes, but lower baseline serum C3 levels were unrelated to prognosis [19]. Conversely, Komatsu et al. did not identify any difference in serum C3 levels between patients with severe ...
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Introduction A reduction in the Ki-67 index after neoadjuvant chemotherapy has been reported to be associated with a favorable prognosis. The present study investigates whether a reduction in Ki-67 may be a predictive surrogate marker of favorable prognosis in each subtype of breast cancer.. Methods A total of 385 patients who received neoadjuvant anthracycline followed by taxane chemotherapy and subsequent surgery for invasive breast cancer were analyzed retrospectively. By immunohistochemistry (IHC), patients were divided into 4 subtypes (Luminal A, Luminal B, Triple negative and HER2). Ki-67 was examined by IHC in pre-treatment core needle samples and post-treatment surgical excisional specimens. The relapse-free survival (RFS) rate was compared among each subtype.. Results The median follow-up period was 56 months. The rate of pathological complete response was higher for HER2 (34.8%) and Triple negative (24.3%) subtypes than for Luminal B (8.3%) and Luminal A (3.8%) subtypes (p < 0.0001). A ...
Background: There is evidence that high level of serum lactate dehydrogenase (LDH) is associated with poorer overall survival in several malignancies, but its link to cancer-specific survival is unclear. Methods: A total of 7895 individuals diagnosed with cancer between 1986 and 1999 were selected for this study. Multivariable Cox proportional hazards regression was used to assess overall and cancer-specific death by the z-score and clinical categories of serum LDH prospectively collected within 3 years before diagnosis. Site-specific analysis was performed for major cancers. Analysis was repeated by different lag times between LDH measurements and diagnosis. Results: At the end of follow-up, 5799 participants were deceased. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall and cancer-specific death in the multivariable model were 1.43 (1.31-1.56) and 1.46 (1.32-1.61), respectively, for high compared with low prediagnostic LDH. Site-specific analysis showed high LDH to correlate ...
Backgrounds: Basal thinning of the interventricular septum (IVS) is one of the key findings for diagnosing cardiac sarcoidosis (CS), and ideal cut-off thickness of basal IVS was previously reported. However long-term prognostic significance of basal thinning of the IVS in CS remains unclear.. Methods: We examined 74 consecutive patients who were initially diagnosed as CS by clinical and/or pathological findings and clearly evaluated basal IVS by echocardiogram. We measured the thickness A which was 10mm distant from the aortic annulus on the IVS and the thickness B which was the one-third point nearby the annulus, and calculated the ratio A/B by the long axis view of the left ventricle at the end-diastolic phase. Patients were divided into two groups according to the presence or absence of basal IVS thinning, defined as thickness A≦4mm and/or ratio A/B≦0.6, as previously reported.. Results: Basal IVS thinning was observed in 21 patients. Age, gender, left ventricular (LV) end-diastolic ...