Full Text - Purpose: This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years).Results: We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC pathological staging system, including 10.7% upstaged and 42.1% downstaged. The receiver operating characteristics analysis showed that the new staging system had a better role in predicting breast cancer-specific survival (BCSS) compared with 7th edition staging (P<0.001). The results of the multivariate prognostic analysis showed that the hazard ratio of BCSS increased with the 8th AJCC stages, while the 7th anatomic stages had no significant difference in BCSS.Conclusions: The novel pathological staging system could provide more accurate prognostic stratification for young women with breast cancer because of the high proportion of stage migration.Patients and Methods:
TY - JOUR. T1 - Extratumoral vascular invasion is a significant prognostic indicator and a predicting factor of distant metastasis in non-small cell lung cancer. AU - Shimada, Yoshihisa. AU - Ishii, Genichiro. AU - Hishida, Tomoyuki. AU - Yoshida, Junji. AU - Nishimura, Mitsuyo. AU - Nagai, Kanji. PY - 2010/7. Y1 - 2010/7. N2 - INTRODUCTION: Vascular invasion is thought to be a fundamental step in hematogenous metastasis. The aim of this study was to assess whether the qualitative evaluation of vascular invasion according to its location (intratumoral or extratumoral) could provide an appropriate means of predicting the prognostic outcome and potential patterns of recurrence in non-small cell lung cancer. METHODS: We reviewed the cases of 1000 consecutive patients in whom complete resection of non-small cell lung cancer had been performed. Sections stained by the Victoria blue van Gieson method were examined for the presence of vascular invasion and the evaluation of its location (v0: absence, n ...
TY - JOUR. T1 - Results and prognosis following surgery for malignant tumors of the skull base. AU - Jackson, Ian T.. AU - Bailey, M. Hugh. AU - Marsh, W. Richard. AU - Juhasz, Peter. PY - 1991. Y1 - 1991. N2 - A series of 155 malignant craniofacial tumors referred to a specialized craniofacial center for surgical treatment are presented. One quarter of these were primary and three quarters recurrent. The statistics of long‐term follow‐up are presented, and it is concluded that this type of surgery for these difficult problems is worthwhile. The increasing experience gained from operating on and following up these patients is presented.. AB - A series of 155 malignant craniofacial tumors referred to a specialized craniofacial center for surgical treatment are presented. One quarter of these were primary and three quarters recurrent. The statistics of long‐term follow‐up are presented, and it is concluded that this type of surgery for these difficult problems is worthwhile. The increasing ...
The mRNA as well as protein expression of SASH1 was strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in colorectal liver metastases. In contrast, SASH1 expression was not significantly altered in benign adenomas and in early stage lesions (UICC I). Around 40% of primary colon tumours tested (n=113) showed a 10-fold or stronger reduction in SASH1 expression, compared to normal colon mucosa. Decreased SASH1 mRNA expression was correlated with the occurrence of metachronous distant metastasis, and multivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival (Rimkus et al., 2006). Recently, these results were confirmed on an independent patient collective of stage II colon cancer (n=179 patients), confirming that decreased SASH1 expression is an independent negative prognostic factor in colon cancer, allowing to distinguish high-risk patients in early, locally restriced stages of the disease ...
TY - JOUR. T1 - Survival predictors in patients with node-negative gastric carcinoma. AU - Lee, Chin Chun. AU - Wu, Chew Wun. AU - Lo, Su Shun. AU - Chen, Jen Hao. AU - Li, Anna F.Y.. AU - Hsieh, Mao-Chih. AU - Shen, King Han. AU - Lui, Wing Yiu. PY - 2007/1/1. Y1 - 2007/1/1. N2 - Background: Presence or absence of nodal metastasis influences outcome of gastric cancer patients. This study gives insight into survival predictors and clinicopathological features of node-negative gastric adenocarcinoma. Methods: Between 1988 and 1999, 689 gastric cancer patients without other cancer or gastrectomy for benign disease who underwent curative resection were enrolled in this study. Clinicopathological data in patients with node metastasis were compared with those without. Results: The survival rate at 5 and 10 years for node-negative cases was 91.7% and 89.7%, respectively. On univariate analysis, node-negative patients were characterized by frequent location in the lower two-thirds of the stomach ...
Long non-coding RNAs (lncRNAs) have important biological functions and can be used as prognostic biomarkers in cancer. To identify a lncRNA prognostic signature for head and neck squamous cell carcinoma (HNSCC).. Researchers at the Shanghai Jiao Tong University School of Medicine analysed RNA-seq data derived from the TANRIC database to identify a lncRNA prognostic signature model using the orthogonal partial least squares discrimination analysis (OPLS-DA) and 1.5-fold expression change criterion methods. The prognosis prediction model based on the lncRNA signatures and clinical parameters were evaluated using the 5-fold cross validation method.. A total of 84 out of 3199 lncRNAs were significantly associated with the survival of patients with HNSCC. Using the OPLS-DA and 1.5-fold change selection criterion, 5 lncRNAs (KTN1-AS1, LINC00460, GUSBP11, LINC00923 and RP5-894A10.6) were further selected. The prediction power of each combination of the 5 lncRNAs was evaluated through the receiver ...
TY - JOUR. T1 - Glasgow prognostic score is an independent marker for poor prognosis with all cases of epithelial ovarian cancer. AU - Omichi, Chiaki. AU - Nakamura, Keiichiro. AU - Haraga, Junko. AU - Masuyama, Hisashi. AU - Hiramatsu, Yuji. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Inflammatory markers are important prognostic factors in various cancers. This study investigated whether inflammatory markers of the Glasgow prognostic score (GPS) predicted progression-free survival (PFS) and overall survival (OS) for patients with all cases of epithelial ovarian cancer (OC). Pretreatment GPS was examined for the correlations with PFS and OS in 216 patients in all stages of epithelial OC. Statistical analyses were performed using the Mann-Whitney U-test. PFS and OS were analyzed using the Kaplan-Meier method. Coxs proportional hazard regression was used for univariate and multivariate analyses. For all patients, the median PFS was 35.1 months, and median OS was 46.7 months; follow-up range was 1-162 ...
Breast cancer prognosis may be worse among black women than among white women regardless of the subtype of breast cancer. These results were presented at the 2013 annual meeting of the American Association for Cancer Research (AACR).. Its long been known that breast cancer prognosis varies by race among women in the United States, with black women tending to have worse outcomes than white women. Some of this variability has been attributed to the fact that black women have higher rates of triple-negative breast cancer than women of other races. How race affects prognosis among women with certain subtypes of breast cancer, however, has been uncertain.. To explore the relationship between race and prognosis by subtype of breast cancer, researchers evaluated 1,688 breast cancer survivors who participated in the Life After Cancer Epidemiology and Pathways studies. Women have been followed for more than six years.. ...
TY - JOUR. T1 - DPP4/CD26 overexpression in urothelial carcinoma confers an independent prognostic impact and correlates with intrinsic biological aggressiveness. AU - Liang, Peir In. AU - Yeh, Bi Wen. AU - Li, Wei Ming. AU - Chan, Ti Chun. AU - Chang, I. Wei. AU - Huang, Chun Nung. AU - Li, Ching Chia. AU - Ke, Hung Lung. AU - Yeh, Hsin Chih. AU - Wu, Wen Jeng. AU - Li, Chien Feng. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Urothelial carcinoma (UC) is common cancer worldwide. The molecular aberrations regarding tumor progression remain unclear. Pericellular proteolysis is crucial in tumorigenesis, but its significance is unexplored in UC. By data mining the datasets in Gene Expression Omnibus, specifically focus on the proteolysis pathway, and followed by a preliminary validation in a pilot batch of tumor samples, we identified that the upregulation of dipeptidyl peptidase 4 (DPP4) was most significantly associated with clinical aggressiveness of UCs. Quantitative RT-PCR confirmed upregulation of DPP4 ...
Individualized approaches to prognosis are crucial to effective management of cancer patients. We developed a methodology to assign individualized 5-year disease-specific death probabilities to 1,222 patients with melanoma and to 1,225 patients with breast cancer. For each cancer, three risk subgroups were identified by stratifying patients according to initial stage, and prediction probabilities were generated based on the factors most closely related to 5-year disease-specific death. Separate subgroup probabilities were merged to form a single composite index, and its predictive efficacy was assessed by several measures, including the area (AUC) under its receiver operating characteristic (ROC) curve. The patient-centered methodology achieved an AUC of 0.867 in the prediction of 5-year disease-specific death, compared with 0.787 using the AJCC staging classification alone. When applied to breast cancer patients, it achieved an AUC of 0.907, compared with 0.802 using the AJCC staging classification
Signal transducer and activator of transcripton-5a (Stat5a) and its close homologue, Stat5b, mediate key physiological effects of prolactin and growth hormone in mammary glands. In breast cancer, loss of nuclear localized and tyrosine phosphorylated Stat5a/b is associated with poor prognosis and increased risk of antiestrogen therapy failure. Here we quantify for the first time levels of Stat5a and Stat5b over breast cancer progression, and explore their potential association with clinical outcome. Stat5a and Stat5b protein levels were quantified in situ in breast-cancer progression material. Stat5a and Stat5b transcript levels in breast cancer were correlated with clinical outcome in 936 patients. Stat5a protein was further quantified in four archival cohorts totaling 686 patients with clinical outcome data by using multivariate models. Protein levels of Stat5a but not Stat5b were reduced in primary breast cancer and lymph node metastases compared with normal epithelia. Low tumor levels of Stat5a but
S100A6 has been implicated in a variety of biological functions as well as tumorigenesis. In this study, we investigated the expression status of S100A6 in relation to the clinicopathological features and prognosis of patients with gastric cancer and further explored a possible association of its expression with epigenetic regulation. S100A6 expression was remarkably increased in 67.5% of gastric cancer tissues as compared with matched noncancerous tissues. Statistical analysis demonstrated a clear correlation between high S100A6 expression and various clinicopathological features, such as depth of wall invasion, positive lymph node involvement, liver metastasis, vascular invasion, and tumor-node metastasis stage (P < 0.05 in all cases), as well as revealed that S100A6 is an independent prognostic predictor (P = 0.026) significantly related to poor prognosis (P = 0.0004). Further exploration found an inverse relationship between S100A6 expression and the methylation status of the seventh and ...
Abstract #3010 Vascular invasion, encompassing both lymphovascular (LVI) and blood vascular invasion (BVI), influences breast cancer patient prognosis. We have previously shown, using an immunohistochemical approach to distinguish between LVI and BVI in a well characterized group of 177 consecutive paraffin-embedded specimens breast cancer patients (52 LN+ and 125 LN-), that VI was detected in 32% of specimens and that 96% of such VI were invasion of lymphatic vessels. The presence of LVI was significantly associated with the presence of metastasis, recurrence and worse disease free interval (DFI) and overall survival (OS). In multivariate analysis, LVI was an independent poor prognostic factor. This original study has been expanded by examining LVI, assessed by podoplanin staining, in 1000 LN-, early stage, breast cancers. In addition to verifying initial results showing the prognostic power of detection of LVI in early stage tumours, it also allowed an examination of LVI in histological and ...
It has been demonstrated in the previous studies that cytogenetics and molecular abnormalities were independent predictors for the prognosis of AML patients [36]-[38]. However, in our study, adverse cytogenetic abnormalities only accounted for 8.6% (n = 93) of patients. The majority of patients was with intermediate and favorable cytogenetics and showed no difference in survival. As Ara-C forms the backbone of the treatment regimen, understanding the contribution of pharmacogenetics to Ara-C response may help dissection of AML with distinct prognosis, so as to individualize chemotherapy and potentially improve the outcomes of AML patients.. In our study, we observed single SNP and SNP-SNP interactions in the Ara-C transport pathway, which could account for the interpatient variability of treatment outcomes in AML patients. When tested independently, both SNP rs324148 and rs9394992 in the SLC29A1gene contributed to Ara-C resistance in patients with AML who received Ara-C based treatment, and they ...
At present, TNM staging is considered the primary predictor of prognosis. However, this predictor has its limitation because patients at the same TNM stage may have a different prognosis. The introduction of laboratory indexes as additional factors is important for the accurate prediction of prognosis.. Recently, a growing body of evidence suggests that inflammatory biomarkers are associated with clinicopathological features and prognosis in patients with CRC. Accordingly, our results showed that LMR, NLR, PLR, PNI were associated with tumor size, tumor depth, and TNM stage. The results of Kaplan-Meier survival analysis with log-rank tests indicated that these inflammatory biomarkers were significantly associated with prognosis in CRC. However, the actual mechanisms of the association between these inflammatory biomarkers and prognosis in CRC are unclear. There are several potential explanations. First, neutrophils, monocytes, and platelets have been reported to promote tumor development via ...
The main findings of this study are the following: 1) CTA shows a better prognostic performance compared with ex-ECG; 2) evaluation of coronary anatomy with CTA may be the first diagnostic tool needed for prognostic stratification of patients with a low to intermediate pre-test likelihood of CAD, whereas ex-ECG may be more appropriate for further prognostic stratification in the subset of patients with CAD ≥50% on CTA; and 3) positive CTA findings identify a shorter event-free survival time regardless of the presence of ischemia at ex-ECG.. In the management of patients with suspected CAD, the prognostic stratification plays a crucial role beyond the simple diagnosis of coronary artery stenoses. Indeed, the occurrence of adverse events determines morbidity and mortality and influences the overall health expenditure. Until few years ago, diagnosis and prognostic evaluation of patients with suspected CAD were made with functional stress tests only in the majority of patients. Nowadays, ex-ECG is ...
Christopher Plass and colleagues find thatOLIG1 expression correlates with survival in lung cancer patients and suggest that it could be used in deciding which patients are likely to benefit from more aggressive therapy.
In this study, doctors from England evaluated baseline prognostic factors in patients with locally advanced or metastatic esophago-gastric cancer. They also assessed whether pretreatment quality of life predicted survival.. The team studied 1080 patients were enrolled in 3 randomized, controlled trials which assessed fluorouracil-based combination chemotherapy, between 1992 and 2001. All patients completed the European Organization for Research and Treatment of Cancer core quality of life questionnaire before randomization. The team found that of the 1080 patients, 91% died. They identified 4 independent poor prognostic factors using multivariate analysis. These were performance status ≤2 (hazard ratio 1.58), liver metastases (HR 1.41), peritoneal metastases (HR 1.33), and alkaline phosphatase ≤100 U/L (HR, 1.41).. The team also constructed a prognostic index which divided patients into good (no risk factor), moderate (1 or 2 risk factors) or poor (3 or 4 risk factors) risk groups. The team ...
A novel finding with potential prognostic impact relates to the observation that 45/149 (30%) of M-CLL cases exhibited high expression of UGT2B17 and displayed poor clinical outcome (P,0.001, Online Supplementary Figure S1). Since the majority of these cases were negative for CD38 expression (134/149, 90%), carried only favorable genomic lesions (del(13q) or no recurrent aberrations (133/145, 92%) and did not display mutations in TP53 (145/149, 97%), NOTCH1 (139/142, 98%) or SF3B1 (140/143, 98%), quantification of UGT2B17 mRNA expression identified a subgroup of progressive M-CLL cases (31/120, 26%) for which, to date, no established prognostic marker has been successful in identifying (Figure 1C). Notably, within M-CLL, high UGT2B17 expression remained as the strongest independent molecular prognostic marker for OS in multivariate analysis (Online Supplementary Table S2). Further evaluation of UGT2B17 expression on clinical outcome in subgroups of CLL with favorable prognosis revealed high ...
Study of Her2/Neu Expression in Breast Carcinoma and Correlation with Various Prognostic Parameters-IJPO-Print ISSN No:-2394-6784 Online ISSN No:-2394-6792Article DOI No:-10.18231,Indian Journal of Pathology and Oncology-IP Innovative Publication Pvt Limited, Medical Journals Publication, Open Access Journals, Print
We aimed to assess whether high-dose preoperative chemoradiotherapy (CRT) improves outcome in esophageal cancer patients compared to surgery alone and to define possible prognostic factors for overall survival. Hundred-and-seven patients with disease stage IIA - III were treated with either surgery alone (n = 45) or high-dose preoperative CRT (n = 62). The data were collected retrospectively. Sixty-seven patients had adenocarcinomas, 39 squamous cell carcinomas and one undifferentiated carcinoma. CRT was given as three intensive chemotherapy courses by cisplatin 100 mg/m2 on day 1 and 5-fluorouracil 1000 mg/m2/day, from day 1 through day 5 as continuous infusion. One course was given every 21 days. The last two courses were given concurrent with high-dose radiotherapy, 2 Gy/fraction and a median dose of 66 Gy. Kaplan-Meier survival analysis with log rank test was used to obtain survival data and Cox Regression multivariate analysis was used to define prognostic factors for overall survival. Toxicity
Population‑based study for predicting the prognosis for breast cancer liver metastasis (BCLM) is lacking at present. Therefore, the present study aimed to evaluate newly diagnosed BCLM patients of different tumor subtypes and assess potential prognostic factors for predicting the survival for BCLM patients. Specifically, data were collected from the Surveillance, Epidemiology and End Results program from 2010 to 2014, and were assessed, including the data of patients with BCLM. Differences in the overall survival (OS) among patients was compared via Kaplan‑Meier analysis. Other prognostic factors of OS were determined using the Cox proportional hazard model. In addition, the breast cancer‑specific mortality was assessed using the Fine and Grays competing risk model. A nomogram was also constructed on the basis of the Cox model for predicting the prognosis of BCLM cases. A total of 2,098 cases that had a median OS of 20.0 months were included. The distribution of tumor subtypes was as ...
The prognostic or predictive role of p53 mutations has remained controversial. Inconsistent associations have been reported between the overexpression of mutant p53 and patient outcome or tumor response to therapy.13,29 A recent meta-analysis suggested that p53 expression is not a significant prognostic marker for human astrocytomas (P = .531, hazard ratio = 1.034).8 Most interesting, the same results were demonstrated in this study. There are 2 possible explanations for this. First, it could be that p53 status has no significant impact on survival prognosis. Second, p53 could interact with a multitude of other factors to influence prognosis.. In the current study, the shortest PFS was identified in patients with mutant p53 tumors localized to VLSM-identified regions when cohorts were subdivided according to tumor location and p53 status. This finding suggests that mutant p53 has a significant influence on the prognosis of tumors involving VLSM-identified regions rather than other regions. ...
The decision to ask about your prognosis is a personal one. Its up to you to decide how much you want to know. Some people find it easier to cope and plan ahead when they know their prognosis and the statistics for how well a treatment might work. Other people find statistics confusing and frightening. Or they might think statistics are too general to be useful. A doctor who is most familiar with your health is in the best position to discuss your prognosis with you and explain what the statistics may mean in your case. At the same time, you should keep in mind that your prognosis can change. Cancer and cancer treatment outcomes are hard to predict. For instance, a favorable prognosis (which means youre likely going to do well) can change if the cancer keeps growing or doesnt respond to treatment. An unfavorable prognosis can change, too. This can happen if treatment controls the AML so it doesnt grow more. ...
Purpose: Previous results from the TransATAC study demonstrated that both the Breast Cancer Index (BCI) and the OncotypeDX Recurrence Score (RS) added significant prognostic information to clinicopathologic factors over a 10-year period. Here, we examined cross-stratification between BCI and RS to directly compare their prognostic accuracy at the individual patient level.. Experimental Design: A total of 665 patients with hormone receptor-positive (HR+) and lymph node-negative disease were included in this retrospective analysis. BCI and RS risk groups were determined using predefined clinical cut-off points. Kaplan-Meier estimates of 10-year risk of distant recurrence (DR) and log-rank tests were used to examine cross-stratification between BCI and RS.. Results: As previously reported, both RS and BCI were significantly prognostic in years 0 to 10. BCI provided significant additional prognostic information to the Clinical Treatment Score (CTS) plus RS (ΔLR-χ2 = 11.09; P , 0.001), whereas no ...
Inflammation can play an important role in cancer progression and the prognostic importance of neutrophil to lymphocyte ratio (NLR), a marker of inflammation, in cancer is a current investigation topic. In the present study, we aimed to determine whether there is a prognostic link between NLR and metastatic gastric cancer (mGC). A total of 143 patients from the Akdeniz University and Antalya Training and Research Hospital database were retrospectively analyzed. The median NLR value was 3.34. The median overall survival (OS) and median progression-free survival (PFS) were 11.6 and 7.9 months, respectively, in patients with NLRvalues were 8.3 and 6.2 months respectively in patients with NLR |3.34 (pstudy showed that increased NLR is an independent prognostic factor associated with short survival in patients with mGC.
The introduction of novel agents in the clinical management of MM has led to the need for new risk predictors and although cytogenetic abnormalities represent strong prognostic factors, their real role in risk prediction is still a matter of debate.. Del(13), del(17p), IGH translocations and high-risk chromosomal abnormalities did not show a significant impact on overall survival or progression-free survival of patients enrolled in the VMP versus VMPT-VT trial. This finding confirms and emphasizes the already reported beneficial role of bortezomib, which seems to overcome the negative impact of poor prognostic cytogenetic features.29,31,33 This was demonstrated not just in the study by Palumbo et al.,31 but also in the bortezomib-based trial by Harousseau et al.,34 which showed a similar progression-free survival between cytogenetically defined high-risk and standard-risk patients. Moreover, the Spanish VISTA trial35, comparing MP and VMP, showed that, in the VMP subgroup, there was no ...
An approach to molecular classification based on the comparative expression of protein pairs is presented. The method overcomes some of the present limitations in using peptide intensity data for class prediction for problems such as the detection of a disease, disease prognosis, or for predicting treatment response. Data analysis is particularly challenging in these situations due to sample size (typically tens) being much smaller than the large number of peptides (typically thousands). Methods based upon high dimensional statistical models, machine learning or other complex classifiers generate decisions which may be very accurate but can be complex and difficult to interpret in simple or biologically meaningful terms. A classification scheme, called ProtPair, is presented that generates simple decision rules leading to accurate classification which is based on measurement of very few proteins and requires only relative expression values, providing specific targeted hypotheses suitable for
The median numbers of involved and dissected LN were 5 (0-50), and and 21 (2-91), respectively. The median follow-up period was 36.7 months. In multivariate analysis, LODDS system was independent prognostic factor for GC mortality (HR:2.02, 95%CI 1.61-2.54; p< 0.0001) and recurrence (HR:2.02 95%CI 1.47-2.77; p< 0.0001). LODDS system significantly discriminated the prognostic groups in patients with 6 to ≤ 10 LN retrieved (plog-rank = 0.022) and 11 to < 15 LN retrieved (plog-rank = 0.014) whereas pN or LNR classifications did not. In patients with ≤ 5 LN retrieved, the prediction of prognosis was insignificant for all 3 staging systems (plog-rank> 0.05). LODDS system also significantly discriminated the prognostic groups both in the patients with D1 and D2 lymphadenectomy, as well as in patients who received adjuvant chemotherapy and radiotherapy. ...
In the population of 129 patients, the only significant correlation between age and clinical-pathological features is between advanced age (,80yr) and tumor location in the right colon (53.7%, p=0.04).. Risk of relapse is related both to depth of tumor invasion (42.9% in stage T4, 6.3% in stage T1, p=0.01) and advanced age (19.5% in ,80yr, 4% in ,65yr).. Overall survival (OS) and disease free survival (DFS) are significantly lower in patients aged over 80 than the other two classes. This significance is maintained by stratifying the 129 patients in the two age classes (,70, ,70).. In the multivariate analysis age , 80yr is significantly correlated with an increased risk of relapse.. Evaluating the control group no significant correlation between relapse and clinical-pathological features was detected.. In the multivariate analysis in stage II population, advanced age doesnt play any significant prognostic role in the risk of recurrence, while a reduction in DFS is related to depth of tumor ...
This page contains the ABSTRACT- Accurate Prognosis in Personal-Injury Cases Using Georges Line http://www.chiro.org/radiology/ABSTRACTS/Accurate_Prognosis.shtml
Exercise and prognosis on the basis of clinicopathologic and molecular features in early-stage breast cancer: The LACE and pathways studies Academic Article ...
Anal cancer treatment options include radiation therapy, chemotherapy, and/or surgery. Major prognostic factors are site, size, and nodal status. Get detailed information about newly diagnosed and recurrent anal cancer and treatment in this summary for clinicians.
Kawaguchi, T., Matsumura, A., et al., 2010. Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer: a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer, 5(7), pp.1001-1010 ...
Conference (2017, April 24). CAF-specific proteins can provide important prognostic markers and targets for anticancer drugs. Recently, integrin α11 (ITGA11) emerged as a new biomarker of CAFs. ITGA11 is mainly expressed by ... [more ▼]. CAF-specific proteins can provide important prognostic markers and targets for anticancer drugs. Recently, integrin α11 (ITGA11) emerged as a new biomarker of CAFs. ITGA11 is mainly expressed by mesenchymal cells and is correlated with fibroblast activation and matrix reorganization. While the role of ITGA11 in wound healing has been well described, only a very limited number of reports have assessed its role in the cancer disease. This research project aims to investigate the role of stromal ITGA11 in breast cancer. To analyze the in vivo effects of ITGA11 on tumor insurgence, growth and metastasis, we crossed the oncogenic MMTv-PyMT mice with the ITGA11 KO/WT mice, which develop spontaneously breast tumors. ITGA11 deletion strongly delayed tumor growth and ...
BACKGROUND: The system to allocate scarce transplantable livers has been criticized for not giving enough weight to the prognoses of the patients receiving the transplants, but little research has been done looking at how the public weights the relative importances of efficacy and equity in distributing the organs. METHODS: This study was an experimental survey of prospective jurors asked to distribute transplantable livers among transplant candidates grouped according to their prognoses. The relative prognoses of the transplant candidates were varied across survey versions. RESULTS: As the prognostic difference between transplant groups increased, the subjects became less likely to distribute the organs equally between them (p less than 0.005). However, the subjects willingness to base allocation on prognosis was moderated by a number of factors, including their understanding of how to use prognostic information and their attitudes toward using prognostic information for individuals versus ...
Our study clearly confirms the prognostic significance of tumor stage both in univariable and multivariable analyses for all cases as well as for the subgroup of resection-only cases. This is in keeping with published literature (2). Tumor histology did not have significant prognostic value with respect to risk of death in the entire cohort or for the subset of resected tumors. Tumor size , 5 cm, increased tumor stage, and age ,70 years were found to be prognostic of risk of death for all cases in multivariable analysis.. One of the strengths of our study was the thorough staging that all subjects underwent. In particular, all of the resected cases were surgically staged in addition to FDG PET staging. Because tumor stage is a strong prognostic factor in NSCLC, any study evaluating potential prognostic measurements depends on thorough staging. Our multivariable statistical analyses included every variable found to be prognostic in univariable analysis.. When considering all cases, our study ...
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buy 1146699-66-2 distal towards the stent). A significant adverse cardiovascular and cerebrovascular event (MACCE) was thought as a amalgamated end stage including all-cause loss of life, MI, cerebral infarction, cerebral hemorrhage, and TLR. Statistical evaluation Categorical and consecutive data are provided as amount (%) and mean regular deviation (SD), respectively. The unpaired check was useful for evaluation of consecutive factors between your two groupings. Chi-square evaluation was utilized to evaluate categorical factors. Long-term event-free success was approximated using KaplanCMeier curves, as well as the log-rank test was used to assess the significance of differences between patients with and without statin treatment. Univariate Cox regression analysis was used to identify cofactors with significant effects on all-cause death in CKD and CAD patients after PCI. Multivariate Cox regression analysis was performed to determine the independent prognostic factors for all-cause death of ...
Targeting of BCL2, a protein involved in the survival of chronic lymphocytic leukemia (CLL) cells, with venetoclax had a manageable safety profile.
3-5% of CRCs show microsatellite instability (MSI) caused by germline defects in mismatch repair genes (MMR) predisposing to Lynch syndrome. In addition, 12% of sporadic CRCs show MSI. Currently, MSI is tested using a fragment analysis based assay not suitable for high throughput testing with suboptimal sensitivity and specificity. Knowledge of microsatellite instability affects prognosis (MSI is a positive prognostic factor in stage II CRC), risk stratification (for the affected and at risk relatives in Lynch syndrome), prediction of lymph node involvement (lymph node metastasis is unlikely in stage I MSI positive CRC) and treatment of CRCs (MMR deficient tumours showed observable benefit from PD-1 blocking agent pembrolizumab). For all these important benefits, MSI testing is now recommended for all newly diagnosed CRCs. As a result, development of a high throughput approach is desirable. We have developed and validated a high throughput sequence based MSI assay.. In this study, we tested 17 ...
Hippocrates included prognosis as a principal concept of medicine.1 Nevertheless, principles and methods of prognostic research have received limited attention, especially compared with therapeutic and aetiological research. This article is the first in a series of four aiming to provide an accessible overview of these principles and methods. Our focus is on prognostic studies aimed at predicting outcomes from multiple variables rather than on studies investigating whether a single variable (such as a tumour or other biomarker) may be prognostic. Here we consider the principles of prognosis and multivariable prognostic studies and the reasons for and settings in which multivariable prognostic models are developed and used. The other articles in the series will focus on the development of multivariable prognostic models,2 their validation,3 and the application and impact of prognostic models in practice.4 ...
Prognostic variables in 251 curative specimens of colonic cancer were studied. Subjective variables--tumour type, grade of differentiation, character of invasive margin and lymphocytic infiltration--were associated with fair to excellent levels of inter-observer agreement. Variables found to be of prognostic significance by univariate analysis were subjected to Cox regression analysis. This was undertaken for all three observers and for a consensus grading. No case in which direct spread in continuity was limited to the bowel wall was associated with a cancer-related death; 63 such specimens were removed as a group with an excellent prognosis and did not require further stratification. In the remaining 188 cases, all showing extramural spread, only lymph node invasion, character of invasive margin and tumour type were independent prognostic variables. The model differs from that developed previously for rectal cancer and is superior to the Dukes classification.
The composition of the investigated liver metastasis of the newly diagnosed BC patients was described in the current research; meanwhile, the survival for these cases was also characterized based on tumor subtypes of BC and metastatic sites. Data were generated based on the SEER program, which included ~30% of the US population; thus, our findings may reflect the experience of the real world population. In addition, Fine and Grays competing risk model based on subdistribution hazards was also recommended to analyze cancer-associated mortality (24). Zhao et al (25) identified the prognostic factors of patients with breast cancer and liver metastasis from 2010 to 2014 using univariate and multivariate Cox regression analyses. Of note, there are several advantages in our research. We used Fine and Grays competing risks model in addition to Cox regression analysis, which to the best our knowledge, has not been reported. We also built a nomogram to predict patient prognosis, which may provide novel ...
TY - JOUR. T1 - Oncogenic pathway combinations predict clinical prognosis in gastric cancer. AU - Ooi, Chia Huey. AU - Ivanova, Tatiana. AU - Wu, Jeanie. AU - Lee, Minghui. AU - Tan, Iain Beehuat. AU - Tao, Jiong. AU - Ward, Lindsay. AU - Koo, Jun Hao. AU - Gopalakrishnan, Veena. AU - Zhu, Yansong. AU - Cheng, Lai Ling. AU - Lee, Julian. AU - Rha, SunYoung. AU - Chung, Hyuncheol. AU - Ganesan, Kumaresan. AU - So, Jimmy. AU - Soo, Khee Chee. AU - Lim, Dennis. AU - Chan, Weng Hoong. AU - Wong, Wai Keong. AU - Bowtell, David. AU - Yeoh, Khay Guan. AU - Grabsch, Heike. AU - Boussioutas, Alex. AU - Tan, Patrick. PY - 2009/10/1. Y1 - 2009/10/1. N2 - Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival. Using gene expression signatures, we devised an in silico strategy to map patterns of oncogenic pathway ...
In order to give a better prognosis, pathologists have used a cancer stage to measure cell tissues and tumors aggressions as an indicator for doctors to choose a suitable treatment. The most widely used cancer staging system is TNM (Tumor, Node, and Metastasis) system [20]. Depending on levels of differentiation between normal and tumor cells, a different histologic grade is given. Tumors with grade 1 indicate almost normal tissues, with grade 2 indicating somewhat normal tissues and with grade 3 indicating tissues far away from normal conditions. Although most of cancers can be adapted to TNM grading system, some specific cancers require additional grading systems for pathologists to better interpret tumors.. The Gleason Grading System is especially used for prostate cancers and a GS (Gleason Score) is given based on cellular contents and tissues of cancer biopsies from patients. The higher the GS are, the worse the prognoses are. The prostate cancer dataset, GSE18655, includes 139 patients ...
A total of 179 patients were randomized/treated. Median OS was 15.2 months (m). When compared to GC + placebo, GC+A 600 demonstrated improved OS and PFS (OS HR = 0.856 and PFS HR = 0.830) versus GC+A 1000 (OS HR = 0.898; PFS HR = 0.927). Results from the post hoc model revealed that KPS, liver metastasis, alkaline phosphatase, and hemoglobin were prognostic. A median prognostic score dichotomized patients into poor and good prognosis groups (50% each group). Patients with poor prognosis treated with GC+A 600 had a greater reduction in risk of death (HR = 0.717) than patients with good prognosis (HR = 1.44). The most significant prognostic factor was KPS ≤80% (35% pts in GC+A 600 vs GC) resulting in HR = 0.50 in favour of GC+A 600. Overall treatment was well tolerated. Most common Grade ≥3 adverse events (AEs) were neutropenia, anemia, thrombocytopenia and hypertension. Frequency of ≥3 Grade toxicities were: 89% (GC), 93% (GC+A 600) and 95% (GC+A 1000). GC+A 1000 had a higher treatment ...
Provide an updated and comprehensive evaluation of the prognostic value of the albumin-fibrinogen ratio (AFR) and the fibrinogen-prealbumin ratio (FPR) for patients with cancer. Four databases (PubMed, Web of Science, Cochrane Library, and WanFang) were searched. The primary endpoints were overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Pooled data were synthesized using StataMP 14 and expressed as hazard ratios (HRs) and 95% confidence intervals (CIs). This update examined 19 studies (7282 cases) that assessed the correlation of AFR with cancer prognosis. Pooled univariate and multivariate analyses indicated significant correlations of low AFR with poor OS (HR 2.18, 95%CI 1.87-2.55 and HR 1.75, 95%CI 1.54-2.00, respectively), poor DFS (HR 1.89, 95%CI 1.54-2.32 and HR 1.51, 95%CI 1.29-1.76, respectively), and poor PFS (HR 1.68, 95%CI 1.42-1.99 and HR 1.48, 95%CI 1.16-1.88, respectively). Pooled univariate and multivariate analyses of 6 studies (2232 cases)
Stromal infiltration of TAMs is a poor prognostic indicator for some solid tumor types (43); however, infiltration of TAMs inside tumor nests, particularly when CD8+ CTLs are also present, can correlate with improved survival outcome (44). These differences might be explained in part by the fact that TAMs produce either protumor or antitumor bioactivities depending on the types of cytokines to which they are exposed (43). TAMs regulated by TH1 cytokines including IFN-γ, TNF-α, and granulocyte monocyte colony stimulating factor enhance TAM cytotoxic activity, production of proinflammatory cytokines, and antigen presentation (45). In contrast, tissue macrophages exposed to TH2 cytokines, immune complexes, or immunosuppressive cytokines instead block CTL activity and promote angiogenesis and tissue remodeling (43, 45). In non-small cell lung cancer, TAMs that localize to tumor nests and correlate with favorable clinical outcomes exhibit an M1/TH1 cytokine profile and express high levels of HLA-DR ...
The concept of prognosis is usual in meteorology. These are estimates which, according to the study by atmospheric conditions, indicate what will happen with the weather in the coming days. Thus, the prognosis may presage sunny or rainy days, anticipating the fall of hail, high winds, etc. Despite the use of various devices and satellites to scientific database, prognosis of Meteorology is not foolproof, because conditions can change without prior index. ...
Factors that affect a childs outlook (prognosis) are called prognostic factors. Learn about prognostic factors in childhood leukemia here.
Key clinical point: A prognostication model identified genes in the tumor microenvironment that are strongly associated with worse prognosis in stage III, estrogen receptor-positive, HER2-negative breast cancer.Major finding: Kaplan-Meier curves showed a significant survival difference in the high- and low-risk groups (hazard ratio, 2.878; P = .05), confirming the validity of the risk score modeling.Study details: Assessment of a risk score model in 98 patients.
Gauging prognosis is a key element when facing treatment decisions in cancer care. Several prognostic tools, such as risk tables and nomograms are at hand to aid this process. In the context of patient-centered care, prognostic tools are of great interest to caregivers and -providers alike, as they can convey sizeable amounts of information and provide tailored, accurate estimates of prognosis. Given the rising number of prognostic tools in cancer care over the last two decades, and similarly, ever increasing presence of the Internet, we aimed to assess how this would translate into the availability of online tools for patient counseling ...
RESULTS: There were 19,363 women with uterine cervical cancer, and 469 women were diagnosed with bone metastases on initial diagnosis (2.42%). Increased T-stage, N-stage, non-squamous and non-adenocarcinoma histology, high-grade tumors, and the presence of lung, liver, and brain metastases were all significantly associated with early bone metastases. There were 364 patients with cervical cancer and bone metastases on initial diagnosis who were followed-up for at least one year. Multivariate Cox regression analysis showed that unmarried status and lung, liver, and brain metastases were significantly associated with reduced overall survival. No other significant risk or prognostic associations were found ...
Conclusions: sST2 levels were correlated with the risk of adverse CV outcomes in hypertensive patients and may represent a useful prognostic marker in these patients. PMID: 32089758 [PubMed - in process]...
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(2015) Tamosiunas et al. PLoS ONE. Aim: To evaluate the additional prognostic value of family history for the estimation of cardiovascular (CVD) mortality risk in middle-aged urban Lithuanian men. Methods: The association between family history of CVD and the risk of CVD mortality was examined in...
A colon cancer prognosis is a prediction as to the outcome of the disease. This eMedTV segment discusses factors that affect a colon cancer prognosis, such as the type and size of the cancer, the stage of the disease, and the persons general health.
An initial validation study presented by Exagen Diagnostics at the San Antonio Breast Cancer Symposium suggests it may soon be possible to distinguish good prognosis from poor prognosis in any newly diagnosed breast cancer patient based on DNA changes in the patients tumor. Those patients identified as having a very good prognosis may do well without chemotherapy or hormonal therapy after their tumors have been removed.
There are more negative prognostic factors in patients with R sided primary, in particular high BRAF MT, and these patients have inferior overall survival when compared to those with a L sided primary. There was no suggestion that site of primary had any impact on bevacizumab effect on PFS. 1SY Brule et al, J Clin Oncol 31, 2013 (supp #3528) 2MK Boisen et al, Ann Oncol 24, 2554-59 ...
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The UNM Comprehensive Cancer Center is the Official Cancer Center of New Mexico and the only National Cancer Institute-designated Comprehensive Cancer Center in the state.
PRIMARY OBJECTIVES:. I. Classify patients with renal tumors by histological categorization, surgico-pathological stage, presence of metastases, age at diagnosis, tumor weight, and loss of heterozygosity for chromosomes 1p and 16q, to define eligibility for a series of therapeutic studies. (Loss of heterozygosity [LOH] testing discontinued as of April 2014) II. Maintain a biological samples bank to make specimens available to scientists to evaluate additional potential biological prognostic variables and for the conduct of other research by scientists.. SECONDARY OBJECTIVES:. I. Monitor outcome for those patients who are not eligible for a subsequent therapeutic study.. II. Describe whether the pulmonary tumor burden correlates with outcome in stage IV patients.. III. Describe the sensitivity and specificity of abdominal computed tomography (CT) by comparison with surgical and pathologic findings for identification of local tumor spread beyond the renal capsule to adjacent muscle and organs, ...
Weʼre raising money to help Dawn make a life time of memories with her children in light of her prognosis. Support this JustGiving Crowdfunding Page.
Good prognosis indicates patients can live longer as long as they can, especially for patients in elderly. So patients are trying to improve prognosis as good as they can. This article will explain how to improve prognosis for patients with
In summary, we compared the clinical outcomes of patients whose tumors were detected by screening examinations with those whose tumors were detected symptomatically. After adjusting for the known prognostic factors and major treatments received, we found the tumor detection method to be an independent predictor of disease recurrence. Specifically, patients with symptom-detected breast tumors had a greater risk of recurrence and death (RR for RFS, 1.34; 95% CI, 1.09-1.66; P = 0.006; RR for BCSS, 1.31; 95% CI, 0.93-1.84; P = 0.117) than patients with screen-detected tumors.. The only tumor characteristic significantly associated with method of detection was Ki-67, when including all four biomarkers in the regression model (the last column in Table 2). Our observation that screen-detected tumors tended to have lower Ki-67 expression and ER-positive status is consistent with earlier observations that screening examinations preferentially identify cancers with these prognostic features (18-20). ...
Results The study population was representative of the Yorkshire stomach cancer population. Survival was poorer with increasing age but it improved significantly from 29.0% (95% CI 23.1% to 35.1%) in 1995-1997 period to 50.5% (95% CI 40.1% to 60.1%) in the 2004-2006 period. Depth of local invasion, nodal stage and completeness of excision are validated as independent prognostic factors in a population setting. Importantly tumour differentiation is shown to be an independent prognostic factor. Patients recorded as well differentiated tumours had significantly better 3-year survival (61.3%; 95% CI 53.2% to 68.4%) compared to moderate (38.4%; 95% CI 33.2% to 43.6%) and poor differentiation (34.1%; 95% CI 30.1% to 38.1%)-Abstract OC-104 figure 1. The effect remains significant after adjusting for age and gender with HR of 1.74 (95% CI 1.11 to 2.71) for moderately differentiated and 2.1 (95% CI 1.3 to 3.4) for poorly differentiated tumours compared to well differentiated tumour. ...
What is the prognosis of stage 5 CKD?The prognosis varies from individual to individual.Some people may live a normal and high-quality life,but some may die in a short time.What factors can affect the prognosis of stage 5 CKD?
Prognostic models are abundant in the medical literature yet their use in practice seems limited. In this article, the third in the PROGRESS series, the authors review how such models are developed and validated, and then address how prognostic models are assessed for their impact on practice and patient outcomes, illustrating these ideas with examples.
... - Get information about diagnosis and prognosis of Intestinal Pseudo Obstruction, onlymyhealth.com is providing articles related to Intestinal Pseudo Obstruction diagnosis and prognosis.
... - Get information about diagnosis and prognosis of Fever, onlymyhealth.com is providing articles related to Fever diagnosis and prognosis.
Most prediction models are developed in secondary care, and it is common to want to apply them to primary care.1 8 9 10 The predictive performance of secondary care models is usually decreased when they are validated in a primary care setting.1 9 One example is the diagnostic model to predict deep vein thrombosis, which had a negative predictive value of 97% (95% confidence interval 95% to 99%) and sensitivity 90% (83% to 96%) in Canadian secondary care patients.11 When the model was validated in Dutch primary care patients, the negative predictive value was only 88% (85% to 91%) and sensitivity 79% (74% to 84%).12 The question arises whether primary and secondary care populations can indeed be considered to be different but similar.. A change in setting clearly results in a different case mix, which commonly affects the generalisability of prognostic models.4 9 13 14 Case mix is here defined as the distribution of the outcome and predictive factors whether included in the model or not. Primary ...
Prognosis describes the likely outcome of a disease, such as the likelihood of recurrence and life expectancy. Find out about prognosis (outlook) and breast cancer.
I have a soft spot in my heart for Hallmark movies, particularly those where everyone overcomes seemingly insurmountable odds and lives happily ever after. The one-legged man wins the marathon, the puppy travels 500 miles through the dessert to make it home for Christmas. The Hallmark gene must be recessive because no one else in my family seems to share my predilection for sappy and predictable made-for-movies endings.. A couple days ago I watched Rogue One with my son and husband. Ok, I 90% watched it. I fell asleep fifteen minutes before the end (SPOILER ALERT) which turned out to be a very good thing. Because I dont like movies where all the good guys die. And no, I dont care if they went down in a spectacular blaze of hero glory. That is still not a happy ending.. At least Rogue One was made up. I could take some consolation in the fact that no live droid was harmed. Not like those "Based on Real Events" movies. You gotta watch out for those.. Years ago, while I was visiting for ...
Why we dont provide information on patient characteristics per clinic: It is understandable that patients would like to use SART clinic outcome reports both as a "report card" to judge quality of care and as a predictor of chance of success for each individual patient. Currently, the SART clinic summary reports cannot be used without context for either purpose. Individual patients within any age range may have more "severe" or less "severe" infertility issues. These diagnosed factors will significantly impact the likelihood of success with ART treatments. Some well-intentioned physicians might strongly discourage or deny care to patients with a predicted low chance of pregnancy. Other physicians may feel ethically obligated to provide ART services to these same well informed "poor prognosis" patients. For this reason, the clinic summary reports are best used as a foundation to discuss the chance of success with your physician. Your SART member physician is in the best position to assess the ...
Why we dont provide information on patient characteristics per clinic: It is understandable that patients would like to use SART clinic outcome reports both as a "report card" to judge quality of care and as a predictor of chance of success for each individual patient. Currently, the SART clinic summary reports cannot be used without context for either purpose. Individual patients within any age range may have more "severe" or less "severe" infertility issues. These diagnosed factors will significantly impact the likelihood of success with ART treatments. Some well-intentioned physicians might strongly discourage or deny care to patients with a predicted low chance of pregnancy. Other physicians may feel ethically obligated to provide ART services to these same well informed "poor prognosis" patients. For this reason, the clinic summary reports are best used as a foundation to discuss the chance of success with your physician. Your SART member physician is in the best position to assess the ...
The writer of the following article has been to a number of seminars about prostate cancer. She found that the men at those seminars held a great interest in their cancer prognosis. The doctors running those seminars devoted a lot of time to explaining
1. Radical surgery. It is supposed to improve prognosis of colon cancer. A surrogate measure of achievement of radical surgery is the number of lym
Distribution of pathological T status on final pathology (a) and overall pathological N status (b) in patients with a preoperative needle-biopsy diagnosis of du
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Phased Innovation Research in Cancer Prognosis and Prediction (R21/R33) PA-06-434. NCI
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Developmental Research in Cancer Prognosis and Prediction (R33) PA-09-159. NCI
Invasion and metastasis are critical determinants of cancer morbidity. Genes and molecules participating in these steps must be regarded as potential prognostic factors. Growth factors and their recep
Summary: Characterization of intratumoral leukocyte populations may help in estimating patients prognosis and predictions. A new study shows remarkable differences between the in situ and invasive breast cancer stages and highlights that cell number analyses should be complemented with characterization of T-cell functions, increasing the likelihood that immune competent antitumor T cells and further biomarkers are identified for guiding therapy choices. Cancer Discov; 7(10); 1062-4. ©2017 AACR.. See related article by Gil Del Alcazar et al., p. 1098. ...
IFOM-IEO Campus Press releasse The biggest European oncological research pole is born the aim of developing and applying genomic research to the field of oncology predictive medicine early molecular diagnosis the evaluation of each patients prognosis based on his/her genetic profile smart drugs genetic testing pharmaco-prevention programs
Prognostic models are used in medicine for investigating patient outcome in relation to patient and disease characteristics. Such models do not always work well in practice, so it is widely recommended that they need to be validated. The idea of validating a prognostic model is generally taken to mean establishing that it works satisfactorily for patients other than those from whose data it was derived. In this paper we examine what is meant by validation and review why it is necessary. We consider how to validate a model and suggest that it is desirable to consider two rather different aspects - statistical and clinical validity - and examine some general approaches to validation. We illustrate the issues using several case studies.
Poor prognosis cancers of the lung, esophagus, pancreas, and liver account for 40% of all cancer deaths and a sizable share of overall cancer care costs. Despit...
For all its threat, deadliness, and the public fear surrounding the disease, the prognosis for prostate cancer is not really that bad. Naturally, for each
AU, Center for Biotechnology & Genomic Medicine. Title: Identification and Characterization of a Proliferative Gene Signature Associated with Survival Prognosis and Chemo- and Radiotherapy Response in Cancer ...
Scientists have developed a technique for evaluating the potency of an AIDS patients T4 lymphocytes. Preliminary findings indicate the new test may provide HIV-positive patients with a more accurate prognosis than current 1
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Pathology articles covering symptoms, diagnosis, staging, treatment, prognosis, and follow-up. Peer reviewed and up-to-date recommendations written by leading experts.
Around 30 percent of patients diagnosed with lung cancer have already reached stage 3, and their prognosis varies according to multiple factors, according to Dr. Lynne Eldridge, writing for...
Critical Care articles covering symptoms, diagnosis, staging, treatment, prognosis, and follow-up. Peer reviewed and up-to-date recommendations written by leading experts.
CKD is a condition characterized by gradual loss of kidney function over time. High risk groups include those with Diabetes and high blood pressure,etc.This article will give its prognosis and prevention.
[Ischemic renal disease: clinical course, prognosis, possibilities of treatment].: The case presented for clinical discussion is a patient suffering from ischem
Prognosis of Trichosporin infection including probable outcomes, duration, recurrence, complications, deaths, and survival rates.
By LAWRENCE FELLOWS A physicians diagnosis of an illness is his identification of it through his examination of the patient. The prognosis is the physicians considered guess about the course of the illness. Incidentally, the condition is diagnosed, not the patient. A physician who thinks he diagnoses his patient should have a good look at…
Prognosis is a prediction about recovery from a disease. Learn the terms you doctor might use, the limitations and cautions, and what it means for you.
Coccidiosis- Diagnosis, Treatment and Prognosis. Diagnosis- I got 5 chickens 4 weeks ago, that were about 4-8 weeks old then. Since then some of their dropp…
Belgian retail chain Delhaize has had a strong second quarter, and therefore raises its prognosis for the entire year. Sales of the group came to 5.3 billion euro, near what analysts had expected, but the underlying company profit of 193 million euro was clearly higher than the anticipated 180 million euro.