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Melengestrol acetate (abbreviated as MGA), sold under the brand names Heifermax and MGA among others, is a progestin which is used in veterinary medicine. It is not approved for use in humans, and is instead used as an implantable contraceptive for captive animals in zoos and other refuges, and is also used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada. MGA is the acetate ester of melengestrol, which in contrast, has never been marketed. MGA, also known as 17α-acetoxy-16-methylene-6-dehydro-6-methylprogesterone or as 17α-acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone. It is specifically a derivative of 17α-hydroxyprogesterone with a methyl group at the C6 position, a methylene group at the C16 position, a double bond between the C6 and C7 positions, and an acetate ester at the C17α position. Analogues of MGA include other 17α-hydroxyprogesterone ...
The objective of this experiment was to determine whether norgestomet implant insertion following melengestrol acetate (MGA) administration altered LH pulse frequency and follicular dynamics. Multiparous Angus cows were randomly assigned to receive MGA (.5 mg*cow-l*d-l ; MGA; n = 14) for 18 d or to receive MGA (.5 mg*cow·-l l*d-l; MGA-N; n = 11) for 15 d and a norgestomet implant for 4 d beginning on d 15. Ultrasound was used to record images of each ovary in cows beginning on d 8 of MGA administration. On d 16, serial blood samples were collected from all cows in replicate one (MGA, n=6; MGA-N, n=6) for quantification ofLH pulse frequency. A persistent, dominant follicle was identified in all cows on d 8 ofMGA administration. Forty-three percent and 64% (P > .10) of MGA and MGA-N cows, respectively, initiated a new wave of follicular development during treatment that was the source of the ovulatory follicle. Pulse frequency of LH did not differ between MGA and MGA-N cows or between cows that ...
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Melengestrol is a medicine available in a number of countries worldwide. A list of US medications equivalent to Melengestrol is available on the Drugs.com website.
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CAS NO:302-22-7; Chemical name:chlormadinone acetate ; physical and chemical property of 302-22-7, chlormadinone acetate is provided by ChemNet.com
Two commercially available progestogen products for cattle, melengestrol acetate (MGA) and norgestomet (SMB) , were evaluated for their ability to induce synchronized estrus in anovulatory ewes. Seasonally anestrous ewes (n=232; determined by blood serum progesterone concentration) of mixed breeding were randomly assigned within broad age groups to one of seven treatments: 1) control (C); 2) MGA only (OMGA); 3) MGA + zeranol (RMGA); 4) MGA + PG-600 (PMGA; 400 IU pregnant mares serum gonadotropin + 200 IU human chorionic gonadotropin in a 5 mL dose); 5) 5MB only (OSMB); 6) 5MB + zeranol (RSMB); and 7) 5MB + PG-600 (PSMB). Beginning 10 d before breeding, OMGA, RMGA, and PMGA ewes were fed .3 mg MGA/d provided through a mixture of shelled com and a commercially prepared pelleted supplement containing MGA. Concomitantly, OSMB, RSMB, and PSMB ewes were given a 3 mg norgestomet implant inserted subcutaneously on the back of the ear. Immediately preceding initiation of the MGA and 5MB treatments, RMGA ...
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T-47D human breast cancer cells grown in culture medium containing low concentrations of fetal calf serum (FCS) proliferated very slowly, with an accumulation of cells in the G2 phase of the cell cycle, increased polyploid cells, and increased expression of transferrin receptors. Cell proliferation was stimulated by the addition of human transferrin or ammonium ferric citrate to the medium. Growth inhibition and accumulation of G2-phase cells could also be produced in T-47D cells grown in medium containing 10% FCS by the addition of the iron chelator, desferrioxamine. It is concluded that cellular deprivation of iron and/or transferrin is the major cause of reduced proliferation rates and G2-phase arrest which accompany the culture of these cells in medium supplemented with low concentrations of FCS.
Complete article is available online.. PDF version is available online.. Treating primiparous sows with altrenogest for 7 days after weaning increased not only the subsequent total number of piglets born, but also the number of piglets born alive and the number of sows returning to estrus after cessation of altrenogest treatment. Farrowing rates were not affected by treatment.. Keywords: altrenogest, second-litter size, primiparous sows. ...
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Natural Progesterone Cream is different from Brand Name Synthetic Progestins. Brand Name synthetic progestins cause birth defects. Natural progesterone does NOT cause birth defects.
Natural progestin - progesterone 21C steroid , derive from cholesterol , secreted by corpus luteum* / placenta* Synthetic progestins - high oral activity -prog…
File Title: Synchronization of estrus and subsequent conception rates in dairy heifers and rats following treatment with melengestrol acetate ...
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Frogs appear to be very sensitive to progestogens, a kind of pharmaceutical that is released into the environment. Female tadpoles that swim in water containing a specific progestogen, levonorgestrel, are subject to abnormal ...
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A little background....after I had a miscarriage in December it took about 45 days for my period to return and this past month is was showing no signs of coming so my doctor gave me progesterone pills to help my period come. Well, it finally came today! So I am hoping that this is what my body needed to get back on track. Im wondering if anyone else has had experience with taking progesterone pills and if you had any luck conceiving afterwards.
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Chlormadinone acetate (abbreviated as CMA), sold under many brand names, is a progestin and antiandrogen. It is used as a hormonal contraceptive in combination with estrogen (under the brand name Belara) and in the treatment of gynecological disorders. It is also used in the treatment of prostate cancer in Japan. CMA is the acetate ester of chlormadinone, which, in contrast to CMA, was never marketed. CMA has been used in the treatment of vaginal bleeding, oligomenorrhea, polymenorrhea, hypermenorrhea, secondary amenorrhea, and endometriosis. It is also used as a hormonal contraceptive in combination with ethinylestradiol. CMA has been widely used in the treatment of prostate cancer in Japan, but has seen little use for indication elsewhere in the world. CMA is used at dosages of 1 to 2 mg/day in oral contraceptives, at dosages of 2 to 10 mg/day in the treatment of gynecological disorders, and at dosages of 50 to 100 mg/day in the treatment of prostate disorders. The human receptor binding and ...
The study was conducted on eighteen postpartum silent oestrus (> 45 days postpartum) Surti buffaloes, divided into three equal groups (6 in each) to evaluate the efficacy of Norgestomet ear implant alone (Gr.-I) and in combination with PGF2α (Gr.-II). The buffaloes in Group-I and Group-II were implanted with Crestar ear implant for 9 days with 2 ml i/m injection of Crestar solution (estradiol Valerate) on the day of implant insertion. In Group-II, additionally 500 μg Cloprostenol was given i/m on one day before implant removal. The buffaloes in Group-III served as untreated silent oestrus controls and were given 5 ml Normal Saline i/m as a placebo treatment on 0 and 8th day. The estrus was induced in cent per cent of buffaloes in the Gr-I and Gr-II with mean estrus induction intervals of 2.17 0.06 and 2.03 0.05 days, respectively. These intervals were significantly (P. Key words: Estrus, Fertility, Norgestomet ear implant, PGF2α, Postpartum Silent oestrus ...
The study was conducted on eighteen postpartum silent oestrus Surti buffaloes to evaluate the efficacy of Norgestomet ear implants alone and in combination with PGF2α. The buffaloes in Group-I & Group-II were implanted with Crestar for 9 days along with 2 ml injection of Crestar solution given on the day of implant insertion. In Group-II, additionally 500 μg Cloprostenol was given on one day before implant removal. Whereas, the buffaloes in Group-III served as silent oestrus control group and 5 ml normal Saline was given on 0 day and on 8th day as a placebo treatment. In the Norgestomet treated groups the significant decreasing trend of endogenous progesterone (P4) concentration observed at different time intervals of ear implant inserted followed by Norgestomet injection given treatment groups of animals. Oestradiol-17β levels of the blood serum did not show any significant difference (p ,0.05) at 0 day, 5th day within the Group-I, Group-II & Group-III. But the mean values of ...
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Radioimmunoassays for 2 synthetic progestins (Ethinyl-norgestrienone, R 2323 and medroxyprogesterone acetate, MPA) are demonstrated. 10 patients aged 31 to
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Sigma-Aldrich offers abstracts and full-text articles by [Kathamuthu Gokul Raj, Shanmugam Sambantham, Ramar Manikanadan, Chinnansamy Arulvasu, Mohan Pandi].