The speech of patients with progressive non-fluent aphasia (PNFA) has often been described clinically, but these descriptions lack support from quantitative data. The clinical classification of the progressive aphasic syndromes is also debated. This study selected 15 patients with progressive aphasia on broad criteria, excluding only those with clear semantic dementia. It aimed to provide a detailed quantitative description of their conversational speech, along with cognitive testing and visual rating of structural brain imaging, and to examine which, if any features were consistently present throughout the group; as well as looking for sub-syndromic associations between these features. A consistent increase in grammatical and speech sound errors and a simplification of spoken syntax relative to age-matched controls were observed, though telegraphic speech was rare; slow speech was common but not universal. Almost all patients showed impairments in picture naming, syntactic comprehension and ...

Mahoney CJ, Downey LE, Beck J, Liang Y, Mead S, Perry RJ, Warren JD. The Presenilin 1 P264L Mutation Presenting as non-Fluent/Agrammatic Primary Progressive Aphasia ...

Here we have demonstrated deficits of flavour identification in two major clinical syndromes of FTLD, bvFTD and svPPA, relative to healthy control subjects. The profile of odour identification performance essentially paralleled flavour identification across subgroups, and there was a significant correlation between flavour and odour identification scores in the patient population. Chemosensory identification deficits here were not simply attributable to general executive or semantic impairment, since the deficits were demonstrated after adjusting for these other potentially relevant cognitive variables. An error analysis showed that identification of general flavour categories was better preserved overall than identification of particular flavours. This pattern would be difficult to explain were impaired flavour identification simply the result of impaired cross-modal labelling. Taken together, the behavioural data suggest that FTLD is often accompanied by a semantic deficit of flavour ...

Looking for online definition of Progressive nonfluent aphasia in the Medical Dictionary? Progressive nonfluent aphasia explanation free. What is Progressive nonfluent aphasia? Meaning of Progressive nonfluent aphasia medical term. What does Progressive nonfluent aphasia mean?

Frontotemporal dementias are a group of disorders featuring progressive decline in behavior or language, with neurodegeneration of the frontal or temporal lobes. In this session, faculty will highlight current diagnostic and management approaches for the most common subtypes of frontotemporal dementia: behavioural variant FTD, nonfluent primary progressive aphasia, and semantic variant primary progressive aphasia. Recent developments in neuroimaging, genetics, and biomarkers related to FTD will be highlighted. Through case presentations, practical approaches to the assessment and management of patients with FTD symptoms will be discussed, including discussion of related disorders that can mimic FTD ...

Waldenstroms macroglobulinemia (WM) is an uncommon low-grade lymphoma. Cognitive impairment due to central nervous system infiltration by lymphoplasmocytoid cells (Bing-Neel syndrome) has been rarely reported. We describe a 54-year-old man who was referred to a memory disorder clinic with a 9-month history of clinically obvious nonfluent aphasia and WM. He underwent extensive neuropsychological testing, clinical examination and structural and functional brain imaging. The diagnosis of the diffuse form of the Bing-Neel syndrome was supported by abnormal lymphoid cells found in the cerebrospinal fluid. Structural and functional brain imaging revealed impairment of brain areas due to white matter changes and subsequent functional deficits mimicking the neuropsychological syndrome encountered in progressive nonfluent aphasia. The diffuse form of Bing-Neel syndrome and neurological deficits are assumed to be the result of leptomeningeal infiltration by malignant cells and/or neoplastic vascular ...

The signs and symptoms for frontotemporal dementia varies from one individual to another. It can easily be mistaken for a psychiatric disorder. Identifying the disease in an individual can be a challenge for the scientists and doctors. Frontotemporal dementia is generally broken down into three subgroups - a behavioral variant and two forms of primary progressive aphasia, the nonfluent variant and the semantic variant.. The behavioral variant is characterized by personality changes, a lack of restraint toward social conventions or behaviors (disinhibition), and a general lack of interest, enthusiasm or concern (apathy). This is the most common subtype of frontotemporal dementia.. Primary progressive aphasia is characterized by the slow onset and gradual progression of language difficulties. Individuals may have difficulty finding the right word or understanding certain words in written or spoken speech. The nonfluent variant is characterized by slow, deliberate, sometimes halting speech ...

ABSTRACTBackground: Progressive neurodegenerative impairment with central language features, primary progressive aphasia (PPA), can be further distinguished for many individuals into one of three variants: semantic, non-fluent/agrammatic, and logopenic variant PPA. ...

Primary progressive aphasia is a rare neurological syndrome that impairs language capabilities. People with primary progressive aphasia may have trouble naming objects or may misuse word endings, verb tenses, conjunctions and pronouns. People with primary progressive aphasia can become mute and may eventually lose the ability to understand written or spoken language. Primary progressive aphasia is a type of frontotemporal dementia, a cluster of related disorders that all originate in the frontal or temporal lobes of the brain.. Primary progressive aphasia specifically targets the language center of the brain - located in the brains left hemisphere. Brain scans typically show a marked shrinkage of the brains language center in people who have primary progressive aphasia. Brain activity also can be diminished.. Symptoms of primary progressive aphasia begin gradually, usually before the age of 65, and tend to worsen over time. Symptoms may vary by individual, depending on which portion of the ...

TY - JOUR. T1 - Primary progressive aphasia. T2 - A 25-year retrospective. AU - Mesulam, Marek-Marsel. PY - 2007/10/1. Y1 - 2007/10/1. N2 - The diagnosis of primary progressive aphasia (PPA) is made in any patient in whom a language impairment (aphasia), caused by a neurodegenerative disease (progressive), constitutes the most salient aspect of the clinical picture (primary). The language impairment can be fluent or nonfluent and may or may not interfere with word comprehension. Memory for recent events is relatively preserved although memory scores obtained in verbally mediated tests may be abnormal. Lesser changes in behavior and object recognition may be present but are not the leading factors that bring the patient to medical attention. This selective clinical pattern is most conspicuous in the initial stages of the disease. Progressive nonfluent aphasia and some types of semantic dementia can be considered subtypes of PPA. Initially brought to the attention of contemporary literature 25 ...

TY - JOUR. T1 - Naming and comprehension in primary progressive aphasia. T2 - The influence of grammatical word class. AU - Hillis, Argye E.. AU - Heidler-Gary, Jennifer. AU - Newhart, Melissa. AU - Chang, Shannon. AU - Ken, Lynda. AU - Bak, Thomas H.. PY - 2006/2/1. Y1 - 2006/2/1. N2 - Background: Various clinical types of primary progressive aphasia have been associated with distinct areas of atrophy and pathological changes. Therefore, differences in the patterns of language deterioration in the various types might reveal the types of language processes and representations that depend on the areas of brain that are disproportionately affected. Aims: To test the hypotheses (1) that individuals with progressive nonfluent aphasia (associated with left posterior, inferior frontal, and insular atrophy) show progressive motor speech impairment and disproportionate deterioration in naming actions relative to objects, and (2) that individuals with semantic dementia (associated with anterior and ...

TY - JOUR. T1 - Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia with the Neuropathology of FTLD-TDP Type A. AU - Mesulam, Marek-Marsel. AU - Nelson, Matthew J.. AU - Hyun, Jungmoon. AU - Rader, Benjamin. AU - Hurley, Robert S.. AU - Rademakers, Rosa. AU - Baker, Matthew C.. AU - Bigio, Eileen H. AU - Weintraub, Sandra. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Four patients with primary progressive aphasia displayed a greater deficit in understanding words they heard than words they read, and a further deficiency in naming objects orally rather than in writing. All four had frontotemporal lobar degeneration-Transactive response DNA binding protein Type A neuropathology, three determined postmortem and one surmised on the basis of granulin gene (GRN) mutation. These features of language impairment are not characteristic of any currently recognized primary progressive aphasia variant. They can be operationalized as manifestations of dysfunction centered on a ...

TY - JOUR. T1 - Examining the value of lexical retrieval treatment in primary progressive aphasia. T2 - Two positive cases. AU - Henry, M. L.. AU - Rising, K.. AU - DeMarco, A. T.. AU - Miller, B. L.. AU - Gorno-Tempini, M. L.. AU - Beeson, P. M.. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Individuals with primary progressive aphasia (PPA) suffer a gradual decline in communication ability as a result of neurodegenerative disease. Language treatment shows promise as a means of addressing these difficulties but much remains to be learned with regard to the potential value of treatment across variants and stages of the disorder. We present two cases, one with semantic variant of PPA and the other with logopenic PPA, each of whom underwent treatment that was unique in its focus on training self-cueing strategies to engage residual language skills. Despite differing language profiles and levels of aphasia severity, each individual benefited from treatment and showed maintenance of gains as well as ...

Perception of nonverbal vocal information is essential in our daily lives. Patients with degenerative dementias commonly have difficulty with such aspects of vocal communication; however voice processing has seldom been studied in these diseases. This thesis comprises a series of linked studies of voice processing in canonical dementias: Alzheimers disease, behavioural variant frontotemporal dementia, semantic dementia and progressive nonfluent aphasia. A series of neuropsychological tests were developed to examine perceptual and semantic stages of voice processing and to assess two aspects of accent processing: comprehension of foreign accented speech and recognition of regional and foreign accents; patient performance was referenced to healthy control subjects. Neuroanatomical associations of voice processing performance were assessed using voxel based morphometry. Following a symptom-led approach, a syndrome of progressive associative phonagnosia was characterised in two detailed case ...

Cognitive impairment after stroke is common and has a major effect on morbidity and quality of life. Acetylcholinesterase inhibitors have demonstrated benefit in vascular dementia, but efficacy in treating more circumscribed cognitive deficits following stroke, such as aphasia, has not been systematically investigated.. This study evaluated the efficacy of Galantamine (Reminyl) in subjects with chronic, stable non-fluent aphasia secondary to stroke. Subjects enrolled in a double-blind placebo- controlled cross-over study that employed a comprehensive battery of language tests and measures of general cognitive and behavioral status that will be used to control for factors that may influence language functioning. The primary study outcome was a within-subject comparison of changes in language function and behavioral scores between placebo and active-treatment phases (12 weeks each). Our hypothesis was that by increasing acetylcholine levels, and facilitating activity of other neurotransmitters ...

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.. During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), an MRI (a non-invasive brain-imaging procedure), an EEG (another non-invasive procedure that looks at brain waves when you think) and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.. The study will recruit approximately 15 participants with PPA per year. For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study. ...

Primary progressive aphasia (PPA) is a clinical dementia syndrome caused by neurodegenerative brain disease, with language impairment as the primary feature. Al...

Primary progressive aphasia is one of several forms of brain disease lost in the medical shadow of a much better known relative, Alzheimers disease.

Accumulation of paired helical filament tau contributes to neurodegeneration in Alzheimers disease (AD). 18 F-flortaucipir is a positron emission tomography (PET) radioligand sensitive to tau in AD, but its clinical utility will depend in part on its ability to predict cognitive symptoms in diverse dementia phenotypes associated with selective, regional uptake. We examined associations between 18 F-flortaucipir and cognition in 14 mildly-impaired patients (12 with cerebrospinal fluid analytes consistent with AD pathology) who had amnestic (n = 5) and non-amnestic AD syndromes, including posterior cortical atrophy (PCA, n = 5) and logopenic-variant primary progressive aphasia (lvPPA, n = 4 ...

Results NfL was higher in all diagnoses, except lvPPA (n = 4), than in controls, equally elevated in behavioral variant FTD, semantic variant PPA, nonfluent variant PPA, and corticobasal syndrome, and highest in FTD-MND. The p/t-tau was lower in all clinical groups, except lvPPA, than in controls and lowest in FTD-MND. NfL did not discriminate between TDP and tau pathology, while the p/t-tau ratio had a good specificity (76%) and moderate sensitivity (67%). Both high NfL and low p/t-tau were associated with poor survival (hazard ratio on tertiles 1.7 for NfL, 0.7 for p/t-tau). ...

WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...

WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...

WEDNESDAY, Jan. 13, 2021 (HealthDay News) -- A rare brain disease that causes loss of language skills doesnt lead to memory loss, a new study finds.. The condition is called primary progressive aphasia and about 40% of people who have it have underlying Alzheimers disease, according to researchers. Their study was published online Jan. 13 in the journal Neurology.. While we knew that the memories of people with primary progressive aphasia were not affected at first, we did not know if they maintained their memory functioning over years, said study author Dr. M. Marsel Mesulam, director of the Center for Cognitive Neurology and Alzheimers Disease at Northwestern University Feinberg School of Medicine in Chicago. This has been difficult to determine because most memory tests rely on verbal skills that these people have lost or are losing, he said in a journal news release.. For the study, Mesulams team assessed 17 people with primary progressive aphasia associated with Alzheimers disease ...

Marta Balagué, neuropsicologa clínica con más de 15 años de experiencia en el diagnóstico neuropsicológico en el campo de procesos neurodegenerativos,

Family members eventually may need to consider long-term care options for the person with primary progressive aphasia. Family members may also need to plan the persons finances and help make legal decisions to prepare for more-serious stages of the condition.. Support groups may be available for you and the person with primary progressive aphasia or related conditions. Ask your social worker or other members of your treatment team about community resources or support groups.. ...

TY - JOUR. T1 - The interpretation of ambiguous dislocations in agrammatism. AU - Gavarró, A.. PY - 2005/1/1. Y1 - 2005/1/1. U2 - 10.1016/j.bandl.2005.07.063. DO - 10.1016/j.bandl.2005.07.063. M3 - Article. VL - 95. SP - 117. EP - 118. JO - Brain and Language. JF - Brain and Language. SN - 0093-934X. IS - 1 SPEC. ISS.. ER - ...

J. Macoir, Lavoie, M., Laforce, R., Brambati, S. M., and Wilson, M. A., Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria., J Geriatr Psychiatry Neurol, vol. 30, no. 3, pp. 151-161, 2017. ...

TY - JOUR. T1 - Right temporal variant frontotemporal dementia with motor neuron disease. AU - Coon, Elizabeth. AU - Whitwell, Jennifer Lynn. AU - Parisi, Joseph E. AU - Dickson, Dennis W. AU - Josephs, Keith Anthony. PY - 2012/1. Y1 - 2012/1. N2 - Patterns of atrophy in frontotemporal dementia (FTD) correlate with the clinical subtypes of behavioral variant FTD (bvFTD), semantic dementia, progressive non-fluent aphasia (PNFA) and FTD with motor neuron disease (FTD-MND). Right temporal variant FTD is associated with behavioral dyscontrol and semantic impairment, with tau abnormalities more common in right temporal bvFTD and TDP-43 accumulation in right temporal semantic dementia. However, no clinical and anatomical correlation has been described for patients with predominant right temporal atrophy and FTD-MND. Therefore, we performed a database screen for all patients diagnosed with FTD-MND at Mayo Clinic and reviewed their MRI scans to identify those with striking, dominant, right temporal lobe ...

The Primary Progressive Aphasia (PPA) syndrome was firstly introduced in 1982. Recently, the primary progressive aphasias were classified into three clinical variants; non fluent/agrammatic, semantic and logopenic.

This information comes to us from The Association for Frontotemporal Degeneration. Logopenic variant Primary Progressive Aphasia Primary progressive aphasia (PPA) is a language disorder that involves changes in the ability to speak, read, write and understand what others are saying. It is associated with a disease process that causes atrophy in the frontal and temporal…

Regions affected late in neurodegenerative disease are thought to be anatomically connected to regions affected earlier. The subcallosal medial prefrontal cortex (SMPC) has connections with the dorsolateral prefrontal cortex (DLPFC), orbitofrontal cortex (OFC), and hippocampus (HC), which are regions that may become atrophic in frontotemporal lobar degeneration (FTLD) and Alzheimers disease (AD). We hypothesized that the SMPC is a common site of frontal atrophy in the FTLD subtypes and in AD. The volume of the SMPC, DLPFC, OFC, HC, and entorhinal cortex (EC) were manually delineated for 12 subjects with frontotemporal dementia (FTD), 13 with semantic dementia (SD), 9 with progressive nonfluent aphasia (PNFA), 10 AD cases, and 13 controls. Results revealed significant volume loss in the left SMPC in FTD, SD, and PNFA, while the right SMPC was also atrophied in SD and FTD. In AD a non significant tendency of volume loss in the left SMPC was found (p = 0.08), with no volume loss on the right side. Results

Brocas aphasia, or non-fluent aphasia, is language disorder after stroke. See a video of a man with Brocas aphasia. Learn what it is & how to help.

Enabling fluent speech in non-fluent aphasia is a TedX talk about a treatment for non-fluent aphasia. This is one of the treatments that we use at SpeechWorks Inc.. An Aphasiologist Has a Stroke is another extremely interesting TedX talk.. Association International Aphasie: learn about Aphasia in many languages, including French.. National Aphasia Association (U.S.A.): information about Aphasia for people with aphasia, caregivers, and professionals. The NAA has an Aphasia Quiz, a good tool for educating people about aphasia.. Aphasia Institute (Canada): information about aphasia from a community-based centre. Aphasia Corner: aphasia simulations - helping family and friends, and people working with people with aphasia, to understand how aphasia feels; Aphasia Corner also has a community-written blog. Aphasia Recovery Connection: online support group connecting people with aphasia, caregivers, and professionals - their FaceBook page quickly addresses questions about aphasia from lots of ...

PDF. Thompson, C.K., Cho, S., Hsu, C.J., Wieneke, C., Weitner, B.B., Mesulam, M.M., & Weintraub, S. (2012). Dissociation between fluency and agrammatism in Primary Progressive Aphasia. Aphasiology, 26(1), 20-43. PMC3244141.. Mesulam, M.M., Wieneke, C., Thompson, C.K., Rogalski, E., & Weintraub, S. (2012). Quantitative classification of Primary Progressive Aphasia at early and mild impairment stages. Brain, 135(5), 1537-1553. PMC3577099.. Thompson, C.K., Cho, S., Price, C., Wieneke, C., Bonakdarpour, B., Weintraub, S., & Mesulam, M.M. (2012). Semantic interference during object naming in agrammatic and logopenic Primary Progressive Aphasia (PPA). Brain and Language, 120, 237-250. PMC3299898.. Rogalski, E., Cobia, D., Harrison, T.M., Wieneke, C., Thompson, C.K., Weintraub, S., & Mesulam, M.-M. (2011). Anatomy of language impairments in Primary Progressive Aphasia. Journal of Neruoscience, 31(9), 3344-3350. PMC3112000.. Hurley, R.S., Paller, K.A., Wieneke, C.A., Weintraub, S., Thompson, C.K., ...

The severity and scope of the problems depend on the extent of damage and the area of the brain affected. Some people may comprehend what others speak relatively well but struggle to find words to speak. Other people may speak more clearly than they can write. Your doctor may refer to one of three broad categories of aphasia nonfluent, fluent and global that describes what region of the brain was damaged and how communication is usually affected. The two primary language networks for most people are located in the brains left hemisphere.. Nonfluent aphasia. Damage to the language network near the left frontal area of the brain usually results in Broca aphasia. Its also called nonfluent aphasia. People with this disorder struggle to get words out, speak in very short sentences and leave out words. A person might say, Want food or Walk park today. Although the sentences arent complete, a listener can usually decipher the meaning. A person with Broca aphasia may comprehend what other people ...

TY - JOUR. T1 - Identification of an atypical variant of logopenic progressive aphasia. AU - Machulda, Mary Margaret. AU - Whitwell, Jennifer Lynn. AU - Duffy, Joseph R.. AU - Strand, Edythe A.. AU - Dean, Pamela M.. AU - Senjem, Matthew L.. AU - Jack, Clifford R Jr.. AU - Josephs, Keith Anthony. PY - 2013/11. Y1 - 2013/11. N2 - The purpose of this study was to examine the association between aphasia severity and neurocognitive function, disease duration and temporoparietal atrophy in 21 individuals with the logopenic variant of primary progressive aphasia (lvPPA). We found significant correlations between aphasia severity and degree of neurocognitive impairment as well as temporoparietal atrophy; but not disease duration. Cluster analysis identified three variants of lvPPA: (1) subjects with mild aphasia and short disease duration (mild typical lvPPA); (2) subjects with mild aphasia and long disease duration (mild atypical lvPPA); and, (3) subjects with severe aphasia and relatively long ...

We defined the neuropsychological and imaging features of the logopenic variant of PPA that in our experience represents 30% of all PPA cases. Our results suggested that the core cognitive deficit in LPA was a phonological loop disorder. Consistently, the imaging investigation showed involvement of GM and WM in the left posterior temporal and inferior parietal regions.. LPA is characterized by a decreased rate of spontaneous language production with frequent halts due to word-finding pauses. Phonemic paraphasias are common, but motor speech and grammar are spared. This pattern of language production is different from the fast output typical of early SemD patients, who usually fill word-finding pauses with circumlocutions and filler words. It is also distinct from the production deficit typical of PNFA, in which articulation deficits and agrammatism predominate.22 LPA patients, therefore, show a pattern of intermediate fluency distinct from the fluent SemDs and the nonfluent PNFAs, raising the ...

A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions.

Researchers from the University of Louisville say their latest study confirms gut bacteria play a role in the development of neurodegenerative diseases. Neurodegenerative diseases such as Parkinsons disease, amyotropic lateral sclerosis, and Alzheimers disease are characterized by misfolded proteins and inflammation of the brain. Scientists say they are unsure about the causes of 90 percent of cases recorded. In the ...

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Does anyone know if Novartis has published the protocol for the arm of the FTY 720 study involving primary progressive patients? Where I can look it up? The trial should start recruiting in January so surely the information is somewhere! ...

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Salza was a zine that was created by high school student Jill Hathaway (using the pseudonym Cleopatrae Jones) in Cedar Rapids, Iowa. She began publishing the zine after encountering A Girls Guide to Taking Over the World at a Barnes and Noble. The zine contained reviews of other zines, interviews with local celebrities, poetry, and personal essays. A total of five issues were created throughout 1997 and 1998 and distributed to various other girl zine publishers, as well as in a local comic book store. Today, there are copies of the zine in the archives of the University of Iowa library. Jill went on in college to produce a one-shot zine entitled Escape from Diet Hell (published in 2002), in which she grappled with her eating disorder and weight issues. She studied to become a high school English teacher and has since produced several zines in the classroom with her students. Jill Hathaway (now Jill Wheeler) currently resides in Van Meter, Iowa, with her husband, Shane (a high school history ...

Background: Hippocampal atrophy on magnetic resonance imaging (MRI) is an early characteristic of Alzheimers disease. However, hippocampal atrophy may also occur in other dementias, such as frontotemporal lobar degeneration (FTLD).. Objective: To investigate hippocampal atrophy on MRI in FTLD and its three clinical subtypes, in comparison with Alzheimers disease, using volumetry and a visual rating scale.. Methods: 42 patients with FTLD (17 frontotemporal dementia, 13 semantic dementia, and 12 progressive non-fluent aphasia), 103 patients with Alzheimers disease, and 73 controls were included. Hippocampal volumetry and the easily applicable medial temporal lobe atrophy (MTA) rating scale were applied to assess hippocampal atrophy.. Results: Multivariate analysis of variance for repeated measures showed an effect of diagnostic group on hippocampal volume. There was a significant diagnosis by side (left v right) interaction. Both FTLD and Alzheimers disease showed hippocampal atrophy compared ...

Accumulating evidence shows that SQSTM1 plays a vital role in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which represent a neurodegenerative disease continuum. Here, we report a novel SQSTM1 variant in a patient presenting with progressive nonfluent aphasia (PNFA) and progressive bulbar palsy (PBP). Relevant literature about FTD and FTD-ALS caused by SQSTM1 mutation was reviewed to better understand its clinical features.We collected data from a 66-year-old male patient with a novel heterozygous variant (c.995C , G, p.S332X) in the SQSTM1 gene who was diagnosed with PNFA and PBP and performed a PubMed literature search using the advanced research criteria: [(frontotemporal lobar degeneration) OR (frontotemporal dementia) OR (amyotrophic lateral sclerosis) OR (motor neuron disease)] AND (SQSTM1). The clinical features of FTD and FTD-ALS related to SQSTM1 mutation were summarized based on previous cases and our new case.The initial symptom ...

Abstract: This thesis examines the feasibility of the ASL for Active Living Program as an intervention for clinical practice among individuals with memory loss and/or aphasia with associated depression. It strives to answer the following questions: First will an eight session RT intervention impact on symptoms of depression in individuals with mild memory loss and aphasia? Second, will participation in this intervention change levels of self-esteem? Third, to what extent will the older adult participants be able to learn and retain finger-spelling and vocabulary taught? Lastly, will participants be satisfied with this type of intervention? The first chapter reports the current trends of an aging society, as well as the increase in co-morbid disorders such as depression. The second chapter provides a thorough literature review which clearly identifies Mild Cognitive Impairment and Primary Progressive Aphasia as well as describes efficacy studies that provide the foundation for this study. The ...

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On this day in 1908 Augusta Déjerine-Klumpke showed the anatomical evidences that lesions to an area deep to the left pars opercularis was associated with nonfluent aphasia. She presented her results during the second meeting, on July 9,1908, of the Société de Neurologie de Paris and constituted a highlight in …. Augusta Déjerine-Klumpke and the oustanding lesson on the anatomy of aphasia Read More ». ...

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I think the most difficult news to share, is the news for those who find themselves with the most disabling form of MS, the primary progressive sufferers. Unfortunately, this group may be the most under-served of the MS Community simply because...

List of words make out of Aphasias. Anagrams of word Aphasias. Words made after scrabbling Aphasias. Word Creation helps in Anagrams and Puzzles.

As a Lingraphica staff member I assist with Lingraphicas Aphasia User Group on a bi-monthly basis. Having never worked with individuals with aphasia before, I

Nominal aphasia is a form of aphasia in which the subject has difficulty remembering or recognizing names which the subject should know well.

Aphasia centers are designed to enhance quality of life by creating a community of people who are all living with aphasia. Typically, they offer conversation

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Terrible news for those of us suffering from primary progressive. Im beyond words... http://biz.yahoo.com/bw/080414/20080414006526.html?.v=1

Learn more about Aphasia at Grand Strand Medical Center DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...

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Is everyday great? Of course not. On those days when my body and brain are not cooperating, I remind myself that I am not invincible. I try to alter my expectations and goals for that day.. ...

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