Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. Creation of a protocol for postoperative care provides a template for further studies of novel therapies or management strategies for primary graft dysfunction ...
TY - JOUR. T1 - Plasma intercellular adhesion molecule-1 and von Willebrand factor in primary graft dysfunction after lung transplantation. AU - Covarrubias, M.. AU - Ware, L. B.. AU - Kawut, S. M.. AU - De Andrade, J.. AU - Milstone, A.. AU - Weinacker, A.. AU - Orens, J.. AU - Lama, V.. AU - Wille, K.. AU - Bellamy, S.. AU - Shah, C.. AU - Demissie, E.. AU - Christie, J. D.. PY - 2007/11. Y1 - 2007/11. N2 - Primary graft dysfunction (PGD), a form of acute lung injury occurring within 72 h following lung transplantation, is characterized by pulmonary edema and diffuse alveolar damage. We hypothesized that higher concentrations of intercellular adhesion molecule-1 (ICAM-1) and von Willebrand factor (vWF) would be associated with the occurrence of PGD. A total of 128 lung transplant recipients among 7 lung transplant centers were enrolled in a multicenter, prospective, cohort study. Blood specimens were collected preoperatively and at 6, 24, 48 and 72 h following lung transplantation. The primary ...
TY - JOUR. T1 - Aprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction. AU - Marasco, Silvana F.. AU - Pilcher, David. AU - Oto, Takahiro. AU - Chang, Wenly. AU - Griffiths, Anne. AU - Pellegrino, Vince. AU - Chan, Justin. AU - Bailey, Michael. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2010/2. Y1 - 2010/2. N2 - Objective: Aprotinin has been widely used to reduce bleeding and transfusion requirements in cardiac surgery and in lung transplantation. A recent study found a significant reduction in severe (grade III) primary graft dysfunction (PGD) in lung transplantation where aprotinin had been used. However, recently, concerns regarding the safety of aprotinin have been raised, and the future use of aprotinin is uncertain. In our institution, aprotinin has been widely used in cardiac surgery and transplantation. We decided to review our lung transplant caseload to investigate the impact of aprotinin on PGD and ...
TY - JOUR. T1 - Clinical risk factors for primary graft dysfunction after lung transplantation. AU - Diamond, Joshua M.. AU - Lee, James C.. AU - Kawut, Steven M.. AU - Shah, Rupal J.. AU - Localio, A. Russell. AU - Bellamy, Scarlett L.. AU - Lederer, David J.. AU - Cantu, Edward. AU - Kohl, Benjamin A.. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta M.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Sonett, Joshua. AU - Wille, Keith. AU - Orens, Jonathan. AU - Shah, Ashish S.. AU - Weinacker, Ann. AU - Arcasoy, Selim. AU - Shah, Pali D.. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Palmer, Scott M.. AU - Christie, Jason D.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - Rationale: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Objectives: We sought to identify donor, recipient, and perioperative risk factors for PGD. Methods: Weperformeda 10-center prospective ...
TY - JOUR. T1 - A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. AU - Shah, Rupal J.. AU - Bellamy, Scarlett L.. AU - Localio, A. Russell. AU - Wickersham, Nancy. AU - Diamond, Joshua M.. AU - Weinacker, Ann. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta. AU - Belperio, John A.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Kawut, Steven M.. AU - Wille, Keith M.. AU - Lederer, David J.. AU - Lee, James C.. AU - Palmer, Scott M.. AU - Orens, Jonathan. AU - Reynolds, John. AU - Shah, Ashish. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Christie, Jason D.. PY - 2012/9. Y1 - 2012/9. N2 - Background: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. Methods: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products [sRAGE] and surfactant protein-D [SP-D]), coagulation cascade (plasminogen ...
TY - JOUR. T1 - Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. AU - Shaver, Ciara M.. AU - Wickersham, Nancy. AU - McNeil, J. Brennan. AU - Nagata, Hiromasa. AU - Sills, Gillian. AU - Kuck, Jamie L.. AU - Janz, David R.. AU - Bastarache, Julie A.. AU - Ware, Lorraine B.. PY - 2017/9/1. Y1 - 2017/9/1. N2 - RATIONALE: Cell-free hemoglobin (CFH) is a potent oxidant associated with poor clinical outcomes in a variety of clinical settings. Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. Preoperative plasma CFH levels are independently associated with primary graft dysfunction (PGD) after lung transplant ( 1 ).OBJECTIVES: Our objectives were to determine whether CFH would increase lung vascular permeability in the isolated perfused human lung and whether APAP would limit these effects.METHODS: Human lungs ...
Background. Enzymatic activity inhibition of CD26/dipeptidylpeptidase IV (CD26/DPP IV) attenuated short-term post-Tx (transplantation) ischemia-reperfusion injury after 18-hr-ischemia. Here, we investigated the effect of intragraft CD26/DPP IV catalytic inhibition on primary graft dysfunction during 7 day post-Tx, following extended ischemia. Methods. A syngeneic rat (LEW [Lewis abstract]) orthotopic lung Tx model was used, grafts exposed to 18 hr cold ischemia before Tx. Controls were flushed and preserved in Perfadex, and harvested after 1 day (CON1) or 7 day (CON7) post-Tx. Investigational groups IN1, IN3, and IN7 grafts were perfused with and stored in Perfadex + inhibitor (AB192) and harvested at 1, 3, and 7 days post-Tx, respectively. Blood gas analysis, peak airway pressure (PAwP), wet/dry weight ratio, myeloperoxidase thiobarbituric acid reactive substances (TBARS), and staining for vasoactive intestinal peptide (VIP) were analyzed. Results. IN1 versus CON1 showed preserved histology, ...
OBJECTIVES: To evaluate the value of cardiac power output index (CPOi) in predicting severe primary graft dysfunction (PGD) after heart transplantation (defined as mechanical circulatory support [MCS] and/or mortality ,30 days after transplant).. DESIGN: Observational cohort study.. SETTING: A heart transplant center in the United Kingdom.. PARTICIPANTS: Consecutive patients who underwent heart transplantation from January 2014 to December 2019 (n = 160). Twenty patients were excluded, as MCS was instituted immediately after transplant.. INTERVENTIONS: None.. MEASUREMENTS AND MAIN RESULTS: Hemodynamic data on return to the intensive care unit (time 0, T0) and at 6 hours (T6) were collected to calculate CPOi at both points in 140 consecutive patients-22 patients developed severe PGD. The CPOi at T0 correlated with donor-recipient predicted heart mass and inversely with inotrope score. Patients who developed severe PGD had significantly lower CPOi at T0 and T6. The areas under the receiver ...
Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. Donor, recipient and allograft-handling factors are thought to contribute, although new insights regarding pathogenesis are needed to guide approaches to prevention and therapy. Mast cells have been implicated in ischemic tissue injury in other model systems and in allograft rejection, leading to the hypothesis that mast cell degranulation contributes to lung injury following reperfusion injury. We tested this hypothesis in a mouse model of PGD involving reversible disruption of blood flow to one lung. Metrics of injury included albumin permeability, plasma extravasation, lung histopathology, and mast cell degranulation. Responses were assessed in wild-type (Kit +/+ ) and mast cell-deficient (Kit W-sh/W-sh ) mice. Because mouse
2016 Elsevier Inc. Background Primary graft dysfunction (PGD) is a frequent complication after cardiac transplantation and remains one of the leading causes of mortality in these patients. The objective of this case-control study is to identify donor and surgical procedures factors associated with PGD, and further guide possible strategies to prevent PGD. Methods Retrospective analysis of the medical records of patients who underwent cardiac transplantation at Memorial Hermann Hospital at Texas Medical Center between October 2012 and February 2015. Results The study population included 99 patients, of which 18 developed PGD. Univariate analysis of donor characteristics revealed opioid use (P =.049) and death owing to anoxia (P =.021) were associated with PGD. The recipient/donor blood type match AB/A was significantly associated with PGD (P =.031). Time from brain death to aortic cross clamp (TBDACC) of ≥3 and ≥5 days were also found to be associated with PGD (P =.0011 and.0003, ...
Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta...
PubMed journal article Primary graft dysfunction and long-term pulmonary function after lung transplantatio were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions. ...
The survival associated with double lung transplantation (LTx) is 7.1 years, however, closer inspection of recipient pre-LTx disease demonstrates that survival amongst COPD patients (related to cigarette smoke [CS] exposure) is amongst the worst at 5.5 years, as compared to 8.9 years in cystic fibrosis patients. A number of risk factors are thought to lead to this observed inferior outcome, chief amongst these, are pre-LTx diagnosis, recipient and donor age, and donor CS history. Indeed, CS exposure in either the recipients or donors has been linked with increased rates of severe primary graft dysfunction, acute rejection (AR), and ultimately earlier graft failure. The goal of these proposed studies is to demonstrate evidence that CS exposure, either donor or recipient, alters the local lung-specific immune environment in such a way as to predispose to exacerbated ischemia-reperfusion injury (IRI), with a resultant worsening of AR. We first examined the role of CS exposure on the lung ...
The incidence of primary graft dysfunction (PDF) after LT is approximately 25% within a range of 9.3 to 43.7% based on different definitions characterizing PDF [1-5]. Initial non-function (INF) develops in up to 6% of all considered cases and requires urgent retransplantation [6].. Risk factors are prolonged cold ischemia time or higher degree of graft steatosis and subsequent development of severe hepatic ischemia/reperfusion injury (IRI) [5, 7]. A cascade of cellular events results in microcirculatory flow disturbance. This may be distinguished as no-flow indicating capillary perfusion failure on the one hand, or reflow-paradox including activation of the leukocyte-endothelium interaction, release of toxic mediators, and impairment of the endothelial barrier on the other hand [8, 9]. There are, obviously, further different factors all contributing to an insufficient function of liver grafts and its detrimental effects on the overall outcome after LT: recipients condition, the donor data, ...
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TY - JOUR. T1 - Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part IV. T2 - Recipient-related risk factors and markers. AU - Barr, Mark L.. AU - Kawut, Steven M.. AU - Whelan, Timothy P.. AU - Girgis, Reda. AU - Böttcher, Heidi. AU - Sonett, Joshua. AU - Vigneswaran, Wickii. AU - Follette, David M.. AU - Corris, Paul A.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - The lack of a clear definition of PGD in many large series of lung transplantation, including the ISHLT registry data, hampers the identification of recipient-related risk factors. Concomitant donor-related variables further confound these analyses. Based on the current body of literature, recipient-related risk factors that would require further study before any association can be stated include the type of procedure, the presence of hepatic dysfunction, and pleural adhesions and/or prior surgery, which increase the risk of post-operative bleeding. Additional factors that may confound the clinical picture or possibly ...
Duvoux, C.; Pawlotsky, J.M.; Cherqui, D.; Metreau, J.M.; Fagniez, P.L.; Duval, J.; Dhumeaux, D., 1994: Value of HCV RNA quantitation in diagnosis of acute graft dysfunction after liver transplantation for HCV-related cirrhosis
When citing a chapter of a book, capitalize as for a journal article title (see , Titles); do not use quotation marks. Inclusive page numbers of the chapter should be given (see also , Page Numbers or Chapter Number). 1. Solensky R. Drug allergy: desensitization and treatment of reactions to antibiotics and aspirin. In: Lockey P, ed. Allergens and Allergen Immunotherapy. 3rd ed. New York, NY: Marcel Dekker; 2004:585-606. 2. Yashiro M, Yanagawa H. Database construction for information on patients with Kawasaki disease. In: Yanagawa H, Nakamura Y, Yashiro M, Kawasaki T, eds. Epidemiology of Kawasaki Disease: A 30-Year Achievement.
Primary graft dysfunction (PGD) is the most common cause of early morbidity and mortality following lung transplant and is characterized by acute lung injury and capillary leak leading to an increase in extravascular lung water index (ELWI) and impaired graft function. PGD has many features in common with acute respiratory distress syndrome (ARDS). PGD may be life-threatening and can also lead to impaired long term lung function. In ARDS, a restrictive fluid strategy has been associated with an improvement in lung function and outcomes. Accurate methods of evaluating, quantifying and guiding the hemodynamic / fluid management and limiting the extent of ELWI that accumulates in the setting of PGD are lacking. Using transpulmonary thermodilution to estimate ELWI and the pulmonary permeability index (PPI) represents a novel approach to fluid management, which has been used in patients with ARDS, but to date not in the transplant setting. To determine if these measurements may better guide the ...
TY - JOUR. T1 - Clinical application of an extracellular phosphate-buffered solution (EP-TU) for lung preservation. T2 - Preliminary results of a Japanese series. AU - Okada, Yoshinori. AU - Matsumura, Yuji. AU - Date, Hiroshi. AU - Bando, Toru. AU - Oto, Takahiro. AU - Sado, Tetsu. AU - Hoshikawa, Yasushi. AU - Noda, Masafumi. AU - Oishi, Hisashi. AU - Kondo, Takashi. PY - 2012/1. Y1 - 2012/1. N2 - Purpose: We evaluated the effect of an extracellular phosphate-buffered lung preservation solution (EP-TU solution) on acute postoperative graft function and recipient survival in a Japanese series of cadaveric lung transplantation. Methods: The subjects were ten patients who received lung grafts preserved with EP-TU solution at three of four designated lung transplant centers between 2000 and 2005. Three of the patients underwent single lung transplantation and seven underwent bilateral lung transplantation. Postoperative graft function was evaluated by primary graft dysfunction (PGD) grade (0-3), ...
BACKGROUND: In an era of increasing ex vivo lung perfusion (EVLP) use, it remains important to describe what outcomes can be achieved without EVLP, by taking an aggressive approach to donor use to maximize lung transplantation. METHODS: Data for all lung transplant donor referrals to the Alfred Hospital in Melbourne, Australia were collected for 2012 to 2013. Donor variables were analyzed and calculated into a previously validated lung donor score. Lung transplant recipient outcome data included the following: primary graft dysfunction; duration of mechanical ventilation; need for cardiopulmonary bypass extracorporeal membrane oxygenation; intensive care and hospital length of stay; 30-day, 1-year, and 3- to 4-year survival rates; rates of acute rejection and chronic lung allograft dysfunction; and peak and 12-month lung function (forced expiratory volume in 1 second ...
We are extremely pleased to enter into this strategic partnership with Lung Rx, said Wade A. Lange, President and CEO of ImmuneWorks. ImmuneWorks and Lung Rx share a common goal of addressing the needs of patients who are suffering from life-threatening pulmonary diseases, that makes Lung Rx a perfect partner for us.. Founded by Indiana University School of Medicine scientists, Michael Klemsz, PhD, and David Wilkes, MD, and Ronald Meeusen, PhD, Managing Partner of MidPoint Food & Ag Fund, ImmuneWorks is developing a treatment for idiopathic pulmonary fibrosis (IPF), which kills more than 40,000 people each year and for primary graft dysfunction (PGD), which is a leading cause of morbidity and mortality following lung transplantation. ImmuneWorks first product, IW-001 (bovine type V collagen, oral solution) is currently under review by the US Food and Drug Administration in anticipation of first human testing in 2010.. We are delighted to form this partnership with ImmuneWorks in these areas ...
Type V collagen may play a role in graft rejection following lung transplants (See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39). It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis (58.8%, 10/17) compared to patients who were negative for the DTH reaction (15.8%, 6/38) (Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8).. Type V and Type XI Collagen ...
Objectives : VAC therapy is actually used routinely in infected thoracic wound. We reported in this presentation an original use in thoracic surgery: VAC therapy to maintain sterile an unclose chest wall in lung transplant after massive bleeding managed with damage control surgery or after brutal lung oedema.. Methods : Lung transplant is an uncommun part in thoracic surgery, performed in specialized center. Surgeons are confronted to major bleeding due to patient background and the frequent use of ECMO in per-operating and post-operative. Furthermore lung tranplants are exposed to a major oedema included in the primary graft dysfunction. We decided to report an originally case series of management of catastrophic bleeding and lung oedema in lung transplantation.. Results : Between January 2014 and august 2016, 100 bilateral lung transplant were performed in our unit. 19 patients were re-operated. Fourteen of them for postoperative hemothorax or bleeding, 4 for anastomotic leakage and 1 for a ...
Objective In lung transplantation, unexpected pulmonary emboli, including thrombi and fat, have been observed with high probability and are associated with potential primary graft dysfunction. We...
Background: Ischemia/reperfusion (I/R) injury is an important cause of renal graft dysfunction. Increases in cold and warm ischemia times lead to a higher risk of early posttransplant complications including delayed graft function and acute rejection. Moreover, prolonged cold ischemia is a predictor of long-term graft loss in kidney transplant patients. Methods: Darbepoetin alfa (DA) and carbamylated nonerythropoietic derivative of erythropoietin (CEPO) protective effects were evaluated in a model of I/R injury after kidney transplantation in both syngeneic and allogeneic combinations. The effects of wortmannin (phosphorylated Akt [p-Akt] inhibitor) administration were also investigated. Serum creatinine was evaluated at 16, 24, 48 hr and at 4 and 7 days posttransplant. Animals were killed 24 hr or 7 days after transplant and kidneys were processed for histological analysis, immunohistochemistry assessment of erythropoietin receptor (EPOR) and β-common chain receptor expression, granulocyte ...
Figure S1: Low donor lung SP-A mRNA-level associates with decreased survival. The graph shows the survival curves for recipients of double lung transplant excluding patient with ILD. This ad hoc analysis was to address the possible selection bias that is shown in Table S1 with greater percentage of ILD and single lung transplant in the study cohort. Lung transplant patients that received lung allografts with low levels of SP-A mRNA expression prior to implantation had significantly reduced survival. The number of patients in each group is indicated in brackets. The x-axis represents the cumulative survival. Circles indicate the censored patients within the analysis. ...
Liver graft dysfunction can deteriorate to complete organ failure and increases perioperative morbidity and mortality after liver transplantation. Therapeutic strategies reducing the rate of graft dysfunction are of current clinical relevance. One approach is the systemic application of prostaglandins, which were demonstrated to be beneficial in reducing ischemia-reperfusion injury. Preliminary data indicate a positive effect of prostacyclin analogue iloprost on allograft viability after liver transplantation. The objective of the study is to evaluate the impact of iloprost in a multi-center trial.
Key Points. Acquired aplastic anemia is a T-cell-mediated autoimmune bone marrow aplasia, without a known etiologic trigger.Clonal expansion of CD8+ effector T
Genetic testing of embryos in IVF is now under low PGD cost in Kolkata, India. Call us at +91 766-866-6633 for embryo biopsy and testing for PGD in Kolkata.
TY - JOUR. T1 - Early primary graft failure after a pediatric heart transplant and successful rescue with plasmapheresis, immunoglobulins, and alemtuzumab. AU - Raj, Shashi. AU - Ruiz, Phillip. AU - Rusconi, Paolo. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Early primary graft failure after pediatric orthotopic heart transplantation (OHT) has a high mortality rate and can occur due to several causes including but not limited to prolonged graft ischemia time, suboptimal preimplant myocardial preservation, hyperacute rejection, and maladaptation of the graft to the hosts hemodynamic status. Mechanical circulatory support with either extracorporeal membrane oxygenation (ECMO) or ventricular assist device has been used for the rescue of primary graft failure in pediatric patients after heart transplant. Cardiac arrest before ECMO initiation in these patients is associated with adverse neurologic outcome although those surviving to hospital discharge generally have excellent long-term outcome. We report a ...
Purpose: Primary graft dysfunction (PGD) is a form of acute lung injury driven by ischemia-reperfusion mediated damage. An increase in plasma complement proteins - specifically C4a and C5a - is associated with PGD, and an increase in C3a and C5a levels is associated with mortality, independent of PGD. However, serum levels appear to be high at baseline post-lung transplantation (LTx); and hence, make it harder to distinguish patients at risk. Given that PGD manifests as an acute lung injury, we hypothesized that local complement activation would help identify those who go on to develop PGD post-LTx.. *Methods: Bronchoalveolar lavage (BAL) specimens were obtained from recipients at 2 and 24h post-LTx. PGD was scored based on the consensus definition at 24, 48 and 72h post-LTx by an investigator blinded to the results. Complement activation proteins were measured using ELISA. Specifically, levels of C4d, indicating classical/lectin pathway activation and soluble C5b-9 (sC5b-9), a marker of ...
Eculizumab: This humanized monoclonal antibody against complement C5 ultimately prevents the formation of C5-9 membrane attack complex and generation of prothrombotic C5a.. Plasma exchange: Plasma exchange can be used to remove the mutated protein and replace them with normal proteins in patients who do not respond to Eculizumab. Transplant patients with auto-antibodies against complement factor H have been successfully treated with plasma- exchange, rituximab and high dose steroids.. Liver- kidney transplantation: There have been some case reports of combined liver and kidney transplantation, which has been successful in treating HUS in patients with complement factor H mutation.. It is important to identify the gene mutation that led to atypical HUS in every patient who is evaluated for kidney transplantation and has a history of atypical HUS, in order to estimate the risk of recurrence and plan eventual prevention therapy. The knowledge of the mutation would also allow appropriate ...
Elliott, Adrian, Skowno, Justin, Prabhu, Mahesh, Noakes, Timothy and Ansley, Les (2015) Evidence of cardiac functional reserve upon exhaustion during incremental exercise to determine VO2max. British Journal of Sports Medicine, 49 (2). pp. 128-132. ISSN 0306-3674 Ong, Lay Ping, Tristan, Z., Prabhu, Mahesh, Parry, Gareth and Clark, Stephen (2014) Prolonged Intensive Care Unit Stay after Bilateral Lung Transplantation - Late Mortality & Functional Outcome? The Journal of Heart and Lung Transplantation, 33 (S4). S294. ISSN 1053 2498 Andreasson, Anders, Karamanou, Danai, Perry, John, Perry, Audrey, Ӧzalp, Faruk, Butt, Tanveer, Morley, Katie, Walden, Hannah, Clark, Stephen, Prabhu, Mahesh, Corris, Paul, Gould, Kate, Fisher, Andrew and Dark, John (2014) The effect of ex vivo lung perfusion on microbial load in human donor lungs. The Journal of Heart and Lung Transplantation, 33 (9). pp. 910-916. ISSN 1053-2498 Dark, John, Karamanou, Danai, Clark, Stephen, Prabhu, Mahesh, Watson, B., Corris, Paul and ...
Warnecke G, Van Raemdonck D, Smith MA, Massard G, Kukreja J, Rea F, Loor G, De Robertis F, Nagendran J, Dhital KK, Moradiellos Díez FJ, Knosalla C, Bermudez CA, Tsui S, McCurry K, Wang IW, Deuse T, Lesèche G, Thomas P, Tudorache I, Kühn C, Avsar M, Wiegmann B, Sommer W, Neyrinck A, Schiavon M, Calabrese F, Santelmo N, Olland A, Falcoz PE, Simon AR, Varela A, Madsen JC, Hertz M, Haverich A, Ardehali A. Normothermic ex-vivo preservation with the portable Organ Care System Lung device for bilateral lung transplantation (INSPIRE): a randomised, open-label, non-inferiority, phase 3 study. Lancet Respir Med. 2018 05; 6(5):357-367 ...
The study population characteristics raise the need to establish a treatment regime that assures suitable intensity immunosuppression to avoid the appearance of rejection episodes, but minimizes the doses to prevent over-immunosuppression in a population with a theoretic minor immune response.. On the other hand, the delay in the introduction of calcineurin inhibitors will prevent increasing the risk of early graft dysfunction allowing the highest post-transplant renal recovery in organs with less operative mass and greater sensibility to the nephrotoxic effect of these drugs.. The results of several studies confirm the goodness of regimes that include low doses of calcineurin inhibitors, delay their introduction or avoid them.. Nevertheless, although it is standard practice to evaluate the effectiveness of the regimes for a time to assure, with certainty, the response to the treatments, these follow-ups are still relatively short to assure the efficacy for a long-term study and to detect the ...
The basis for increased mortality after heart transplantation in African Americans and other non-Caucasian racial groups is poorly defined. We hypothesized that increased risk of adverse events is driven by biologic factors. To test this hypothesis in the Invasive Monitoring Attenuation through Gene Expression (IMAGE) study, we determined whether the event rate of the primary outcome of acute rejection, graft dysfunction, death, or retransplantation varied by race as a function of calcineurin inhibitor (CNI) levels and gene expression profile (GEP) scores.We determined the event rate of the primary outcome, comparing racial groups, stratified by time after transplant. Logistic regression was used to compute the relative risk across racial groups, and linear modeling was used to measure the dependence of CNI levels and GEP score on race.In 580 patients monitored for a median of 19 months, the incidence of the primary end point was 18.3% in African Americans, 22.2% in other non-Caucasians, and ...
Twenty children with a median age of 20 months (1.5-185) and a male/female sex ratio of 1.5 underwent DW-MRI after CA with a median delay of 3 days (1-7). Aetiologies of CA were (i) asphyxia (n = 10), (ii) haemodynamic (n = 5) or (iii) unknown (n = 5). With regard to DW-MRI findings, the unfavourable outcome group (n = 8) was associated with cerebral cortex (p = 0.02) and basal ganglia (p = 0.005) lesions, with a larger number of injured brain regions (p = 0.001) and a global decrease in measured ADC signal (p = 0.008). Normal DW-MRI (n = 5) was exclusively associated with the favourable outcome group (n = 12).. ...
Airway complications following lung transplantation remain a significant cause of morbidity and mortality. The management of bronchial complications in Bronchus Intermedius (BI) is challenging due to the location of right upper bronchus. The aim of this study was to analyze the results of BI Montgomery T-tube stent in a consecutive patients with lung transplantations. Between January 2007 and December 2010, 132 lung transplantations were performed at Foch Hospital, Suresnes, France. All the patients who had BI Montgomery T-tube after lung transplantation were included in this retrospective study. The demographic and interventional data and also complications were recorded. Out of 132 lung transplant recipients, 12 patients (9 male and 3 female) were entered into this study. The indications for lung transplantation were: cystic fibrosis 8 (67%), emphysema 3 (25%), and idiopathic pulmonary fibrosis 1 (8%). Most of the patients (83%) had bilateral lung transplantation. The mean interval between lung
Fingerprint Dive into the research topics of Thrombotic microangiopathy caused by severe graft dysfunction after living donor liver transplantation: Report of a case. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Reconstruction of pulmonary artery with donor aorta and autopericardium in lung transplantation. AU - Noda, Masafumi. AU - Okada, Yoshinori. AU - Saiki, Yoshikatsu. AU - Sado, Tetsu. AU - Hoshikawa, Yasushi. AU - Endo, Chiaki. AU - Sakurada, Akira. AU - Maeda, Sumiko. AU - Oishi, Hisashi. AU - Kondo, Takashi. PY - 2013/7/1. Y1 - 2013/7/1. N2 - A 44-year-old man with Eisenmengers syndrome due to ventricular septal defect (VSD) was listed for lung transplantation. The patients condition was complicated by a giant pulmonary artery (PA) aneurysm. Concurrent VSD closure and total reconstruction of the recipient PA with the donor aorta were planned. When the patient underwent bilateral lung transplantation, the aortic graft obtained turned out to be too short to complete the reconstruction. A PA graft made of the recipients pericardium was successfully interposed between the donors PA and the donors aortic graft.. AB - A 44-year-old man with Eisenmengers syndrome due to ...
Lung Transplantation may be suitable for those patients, physically eligible to undergo a major transplant operation.. In IPF patients, lung transplantation reduces the risk of death by 75% as compared with patients who remain on the waiting list.. Since the introduction of the lung allocation score (LAS), which prioritizes transplant candidates based on survival for lung transplantation in the USA.. Symptomatic patients with IPF younger than 65 years of age and with a body mass index (BMI) ≤ 26kg/m² should be referred for lung transplantation, but there are no clear data to guide the precise timing for LT.. Bilateral lung transplantation is superior to single lung transplantation in patients with IPF ...
Birch, Jodie, Sunny, Syba, Hester, Katy, Parry, Gareth, Gould, F. Kate, Dark, John, Clark, Stephen, Meachery, Gerard, Lordan, James, Fisher, Andrew, Corris, Paul and De Soyza, Anthony (2018) Outcomes of lung transplantation in adults with bronchiectasis. BMC Pulmonary Medicine, 18. ISSN 1471-2466 Sithamparanathan, Sasiharan, Thirugnanasothy, Logan, Clark, Stephen, Dark, John, Fisher, Andrew, Gould, Kate, Hasan, Asif, Lordan, James, Meachery, Gerard, Parry, Gareth and Corris, Paul (2016) Observational study of lung transplant recipients surviving 20 years. Respiratory Medicine, 117. pp. 103-108. ISSN 0954-6111 Ong, Lay Ping, Thompson, Emily, Sachdeva, Ashwin, Ramesh, B. C., Muse, Hazel, Wallace, Kirstie, Parry, Gareth and Clark, Stephen (2016) Allogeneic blood transfusion in bilateral lung transplantation: impact on early function and mortality. European Journal of Cardio-Thoracic Surgery, 49 (2). pp. 668-674. ISSN 1010-7940 Ong, Lay Ping, Sachdeva, Ashwin, Ramesh, Bandigowdanapalya Channaiah, ...
This hospital was formerly the Willis F. Pierce Memorial Hospital. It has 2,200 beds and more than 400 staff members with senior (chief and deputy chief) professional titles. Over 65% of the staff holds masters or doctoral degrees. Its number of allogeneic heart transplants performed leads the nation. Its pediatric heart transplantation and heart re-transplantation fill a gap in this field in China. Its technology in liver transplantation heart re-transplantation and bilateral lung transplantation lead the nation.188. Since its Heart Surgery Department conducted the first orthotopic heart transplant in Fujian Province in 1995, it has successfully performed heart transplants for patients with advanced heart disease from more than 30 cities and regions of China. Its specialty ranks among the best in allogeneic heart transplantation, holds 16 first in the country titles, and serves as the base for heart transplantation in China.. It helped more than 40 large hospitals in large cities such as ...
CD8+ T-cell maturation following lung transplantation: the differential impact of CMV and acute rejection.: Studies on persistent viral infections demonstrate t
During the last 20 years, there has been a shift away from combined heart-lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be t
BackgroundThe ABO blood group system is clinically important in kidney transplantation, but ABO genotyping fails to attract sufficient attention in some countries and regions. We identified one case of early graft dysfunction due to an ABO genotype mismatch. Here, we performed ABO genotyping in blood samples, analyzed grouping discrepancies, and investigated the weak A subgroup frequency in kidney transplantation candidates.MethodsBlood samples from 302 uremic patients with grouping discrepancies and 356 uremic patients with type A blood were analyzed using standard serologic serotyping techniques. The ABO genotypes and alleles were analyzed by polymerase chain reaction sequence-specific primer (PCR-SSP) and sequence-based typing (PCR-SBT).ResultsAll 302 uremic patients with grouping discrepancies carried weak ABO subgroup alleles and 77.48% carried irregular ABO antibodies. The discrepancy rate between serotyping and genotyping was 42.38%, and the mismatching rate of donor selection according to
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PURPOSE: Humoral immunity is maintained by long lived memory B and plasma cells, both of which arise from the activation and differentiation of naïve
ABSTRACT Objective: The objective of this research was to analyse the effects of overweight and obesity in relation to markers of chronic graft dysfunction (ie dyslipidemia, high blood pressure, and proteinuria), and study their impact on the quality of life of kidney graft recipients in the first-year after transplantation. Material and methods: This study monitored 1500
Within the last decade, antibody-mediated (humoral) rejection continues to be recognized as a typical reason behind graft dysfunction after organ transplantation and a significant determinant for graft loss. and high-affinity storage B cells (6, 7). B cell depleting therapies have already been used to regulate the forming of DSA in transplant recipients (8) but arent generally utilized as maintenance treatment due to the chance of unwanted effects. Predicated buy 918659-56-0 on their pivotal function in regulating humoral immunity it could be postulated that Tfh cells, instead of B cells, could possibly be geared to inhibit the introduction of antibody-mediated anti-donor reactivity. Presently, no Tfh-specific agencies have been examined in stage II or III studies. Several animal research and a small amount of clinical research in body organ transplant recipients possess Thy1 demonstrated the significance of Tfh cells along the way of alloantibody creation (9). The precise ramifications of ...
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