TY - JOUR. T1 - Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. AU - Zhao, Bojun. AU - Cai, Jun. AU - Boulton, Mike. PY - 2004/11. Y1 - 2004/11. N2 - Placenta growth factor (PlGF) has been implicated in both physiological and pathological angiogenesis; however, little is known about what regulates its expression. In this study, retinal microvascular endothelial cells and pericytes were exposed to varying concentrations of VEGF and glucose and PlGF expression measured by RT-PCR and Western blotting. Both PlGF mRNA and protein were observed in unstimulated microvascular endothelial cells with only weak expression in pericytes. In endothelial cells, VEGF (100 ng/ml) and glucose (15 mM) induced an increase in expression of PlGF at both the mRNA and protein level while no effect was observed for pericytes. The increase in PlGF expression could be totally abolished by blocking VEGFR-2, and in the case of glucose by neutralising VEGF. VEGF-stimulated PlGF ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Publishers, "Placental Growth Factor (PIGF) Blockers-Pipeline Insights, 2016″, report provides in depth insights on the pipeline drugs and their development activities around the Placental Growth Factor (PIGF) Blockers. The Publishers Report covers the product profiles in various stages of development including Discovery, Pre-clinical, IND, Phase I, Phase II, Phase III and Preregistration. Report covers the product clinical trials information and other development activities including technology, licensing, collaborations, acquisitions, fundings, patent and USFDA & EMA designations details. Publishers Report also provides detailed information on the discontinued and dormant drugs that have gone inactive over the years for Placental Growth Factor (PIGF) Blockers. Publishers Report also assesses the Placental Growth Factor (PIGF) Blockers therapeutics by Monotherapy, Combination products, Molecule type and ...
Placenta growth factor (PlGF) is known to induce angiogenesis and protect placental trophoblast from apoptosis. We have shown that PlGF mRNA expression is increased in hypoxic human myocardium and in rat neonatal ...
As reported in this weeks JAMA, low urine levels of placental growth factor seem to predict preeclampsia before other typical clinical signs of the condition become apparent.
Cassidy, Aedin, Chiuve, Stephanie E., Manson, JoAnn E., Rexrode, Kathryn M., Girman, Cynthia J. and Rimm, Eric B. (2009) Potential role for plasma placental growth factor in predicting coronary heart disease risk in women. Arteriosclerosis, Thrombosis, and Vascular Biology, 29 (1). pp. 134-139. ISSN 1079-5642 Full text not available from this repository. (Request a copy ...
In ruminants, Interferon tau (IFNT) is the pregnancy recognition protein produced by the mononuclear trophectoderm of the conceptus, and is secreted into the uterine lumen during the peri-attachment period. In our previous study, the high-throughput RNA sequencing (RNA-seq) data obtained from bovine conceptuses during the peri-attachment period identified two IFNT mRNAs, IFNT2 and IFNTc1. However, how each of these IFNT variants regulates endometrial gene expression has not been characterized. Using RNA-seq analysis, we evaluated how IFNT2 and IFNTc1 affected transcript expression in primary bovine endometrial epithelial cells (EECs). IFNT treatment induced 348 differentially expressed genes (DEGs); however, there are few DEGs in IFNT2 or IFNTc1 treated EECs, indicating that IFNT2-induced DEGs were similar to those induced by IFNTc1 treatment. In in silico analysis, we identified four IFNT2- and IFNTc1-induced pathways: 1) type II interferon signaling, 2) proteasome degradation, 3) type III interferon
Background: PlGF, a member of VEGF family, beneficially stimulates wound healing process after ischemic tissue injury. We previously reported that PlGF is rapidly produced within infarct myocardium, and the plasma level of PlGF in patients with acute myocardial infarction (MI) is positively correlated with number of monocytes and CD34-positive cells as well as improvement of cardiac function. However, it remains unclear how PlGF promotes healing process after MI.. Methods and Results: Using C57BL/6 mice, recombinant human PlGF (rhPlGF) (10 μg) was infused into the peritoneal cavity for 48 hours after MI. 28-day survival rate was significantly improved (rhPlGF 70.0%, PBS 33.3% p,0.05). Cardiac function was also improved by rhPlGF administration (Left ventricular diastolic diameter; rhPlGF 4.50±0.46mm, PBS 5.14±0.38mm p,0.01, Ejection fraction; rhPlGF 40.6+9.17%, PBS 25.7+7.23% p,0.01). In infarct area, both CD31-positive vascular endothelial cells (rhPlGF 644.6+90.54/mm2, PBS 459.0+73.89/ mm2 ...
Background In recent years it has been found, that angiogenetic factors like the placental growth factor (PlGF, a member of the VEGF family) provide strong prognostic information. However, no data are available for the relevance of the soluble PlGF receptor (sFlt-1, VEGF-R1). Therefore it was our aim to investigate the prognostic value of sFlt-1 in patients presenting with ACS.. Methods and results 1136 consecutive patients (age 64±12 years; 347 females) with an ACS within the last 48 hours were included. Follow up data were available for 1128 (99.3%) patients. Serum samples on admission were available for 1096 (97%) patients and from 821 (72%) patients a second sample the day following admission. Values of sFlt-1 and PlGF on admission were elevated and declined from admission to day 1 (777 vs. 99 pg/ml; p,0.001 and 22.2 vs. 17.2 pg/ml; p,0.001). During follow up 77 (6.8%) patients deceased. There was no difference of PlGF levels on admission and at day 1 between patients who survived and those ...
Placental Protein is popular skin-whitening agent in Japan. This ingredient is recognized for its exemplary capability to visibly whiten skin, remove wrinkles and fine lines, speed up skin cell renewal and detoxifies the body. Horse and Marine Placental Protein is the most effective and safe kind of Placental Protein for cosmetics or skin care use. These ingredients are patented in Japan for their clinically-proven safe and effective skin-whitening, anti-aging and skin renewal properties.. ...
... , Authors: Hannu Koistinen, Markku Seppälä. Published in: Atlas Genet Cytogenet Oncol Haematol.
It has recently been demonstrated that sFLT-1 and PlGF have a high predictive value for the diagnosis and the prediction of preeclampsia, but the interest of introducing these markers in clinical practice has not been demonstrated yet. The diagnostic and predictive value of the sFlt-1/PlGF ratio in patients at risk of placenta-related disorders has been shown in the recent literature and estimation of the sFlt-1/PlGF ratio has become an additional tool in the management of these disorders, primarily PE. This ratio can distinguish the patients that develop maternal or perinatal complications in the next 7-14 days from those with uncomplicated pregnancy. Women with an sFlt-1/PlGF ratio,38 do not have PE at the time of the test and in all likelihood will not develop PE for at least 1week; it is thereby of great value for reassuring the clinician and the patient. Up to 80% of patients are supposed to be in this patient group; therefore, clinicians are able to exclude the majority of patients and ...
PAA114Mu01, Polyclonal Antibody to Placenta Growth Factor (PLGF), 胎盘生长因子(PLGF)多克隆抗体, PlGF2; PGF; PGFL; Placental Growth Factor-Like; Vascular Endothelial Growth Factor-Related Protein | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Table 2: sFlt-1/PlGF Ratio as a Predictive Marker in Women with Suspected Preeclampsia: An Economic Evaluation from a Swiss Perspective
Objective:To evaluate whether a single determination of the serum sFlt-1/PlGF ratio associates with pregnancy prolongation and adverse outcome in women with suspected or confirmed preeclampsia (PE) and whether this ratio has additive value in addition to the current standard diagnosis of PE.Design a
The retroviral envelope-derived proteins syncytin-1 and syncytin-2 (syn1 and syn2) drive placentation in humans by forming a syncytiotophoblast, a structure
Embryonic development is certainly a time-sensitive period that will require a synchronized uterine environment which is established with the secretion of proteins from both embryo and uterus. immunoblotting. We determined a unique personal profile for NVP-BEZ235 EP luminal liquid; 15 proteins linked to specific areas of embryonic advancement including development and remodeling disease fighting capability regulation oxidative tension balance and diet had been significantly changed (up to 65-fold of NP) in EP profile. Particular uterine redecorating proteins such as for example transgelin (= 0.008) and placental protein NVP-BEZ235 like PP9 (= 0.02) were within EP luminal liquid but were barely detectable in the NP flushings. Direct correlations (= NVP-BEZ235 0.01) were observed between proteomics and immunoblotting. These data offer information on powerful physiological processes connected with EP at the amount of the uterus and conceptus and could potentially show a personal profile connected ...
Placental Growth Factor-1 Human Recombinant produced in E.Coli is a non-glycosylated, disulfide-linked homodimer consisting of 2x132 amino acids.
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Prospective epidemiological studies indicate that regular exercise during the year prior to conception reduces preeclampsia risk, whereas exercise during affects pregnancy reduces preeclampsia risk only at specific dosages, or in specific subpopulations. The risk of severe preeclampsia is increased among women who exercise for more than 270 minutes/week in early pregnancy. Physiology studies are needed to identify mechanisms through which regular exercise may influence preeclampsia risk. This dissertation examined the effects of pregnancy (30-36 weeks gestation), and regular exercise participation, on two important pathophysiological features of preeclampsia; circulating anti-angiogenic markers, represented by soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sEng), and endothelial dysfunction. The results demonstrate that regularly exercising, pregnant non-smoking women have higher levels of serum placental growth factor (PlGF), lower levels of serum sFlt-1 and sFlt-1:PlGF, and ...
Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase ...
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OBJECTIVES: To examine whether syncytin-1 has immune regulatory functions and is carried by human placental exosomes. Further, to examine whether corticotropin-releasing hormone (CRH) can induce the production of syncytin-1. STUDY DESIGN: Human placental exosomes were isolated from placental explant, primary trophoblast and BeWo cell cultures. The presence of exosomes was confirmed by transmission electron microscopy and western blotting. Exosomal protein was probed with 3 separate antibodies targeting syncytin-1. Syncytin-1 immunosuppression was tested, using either a syncytin-1 recombinant ectodomain protein or a synthetic peptide with the human syncytin-1 immunosuppressive domain sequence, in an in vitro human blood culture system immune challenged with LPS or PHA. The inhibition of cytokine production by syncytin-1 was determined by ELISA of TNF-α, IFN-γ and CXCL10. BeWo cells were stimulated with CRH or vehicle for 24 h. mRNA and Protein was extracted from the cells for real-time PCR and ...
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390). [supplied by OMIM, Oct 2009] ...
These proteins belong to the immunoglobulin gene superfamily. Human PSGs are composed of an immunoglobulin variable-like domain (red circle) and a variable number of constant-like domains (blue circles). As the figure shows, mouse PSGs are built slightly differently. This supports the idea that PSGs evolved separately on the rodent and primate lineages. ...
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Tytuł projektu: Rozbudowa i przekształcenie bibliograficznej bazy danych AGRO w bazę bibliograficzno-abstraktową z wykorzystaniem oprogramowania YADDA. Nr umowy: POIG 02.03.02-00-031/09 (okres realizacji 2009-2013 ...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
Thompson, John A.; Koumari, Rosa; Wagner, Klaus; Barnert, Sabine; Schleussner, Cathrin; Schrewe, Heinrich; Zimmermann, Wolfgang; Müller, Gaby; Schempp, Werner; Zaninetta, Daniela; Ammaturo, Domenico und Hardman, Norman (1990): The Human Pregnancy-Specific Glycoprotein Genes are Tightly Linked on the Long Arm of Chromosome 19 and are Coordinately Expressed. In: Biochemical and Biophysical Research Communications, Vol. 167, Nr. 2: S. 848-859 [PDF, 1MB] ...
Small for gestational age (SGA) infants are at increased risk of type 2 diabetes in adulthood. It is unknown whether any prenatal biomarkers are helpful for identifying SGA infants with altered metabolic health profile at birth or later life. In a nested study of 162 SGA (birth weight P P = 0.005), IGF-I (P P P = 0.002) concentrations. In SGA infants with both low (P = 0.01). SGA infants with low maternal circulating PlGF levels at late gestation were characterized by greater decreases in cord blood IGF-I and leptin concentrations. Maternal circulating PlGF appears to be associated with neonatal metabolic health profile in SGA infants.
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Results of recent studies in sheep support the concept that PGs regulate expression of elongation- and implantation-related genes in the endometrial epithelia of ruminants during early pregnancy and are involved in conceptus elongation [46, 60, 98] (Figures 1 and 2). The conceptus and endometria synthesize a variety of PGs during early pregnancy in both sheep and cattle [99-104]. The endometrium produces and uterine lumen contains substantially more PGs during early pregnancy than during the estrous cycle [105-107]. The dominant cyclooxygenase expressed in both the endometrium and trophectoderm of the elongating conceptus is PTGS2 [104-106]. Although the antiluteolytic effects of IFNT are to inhibit expression of the OXTR in the endometrial LE and sGE of early pregnant ewes, it does not impede up-regulation of PTGS2, a rate-limiting enzyme in PG synthesis [102, 107]. In sheep, PTGS2 activity in the endometrium is stimulated by IFNT, and PTGS2-derived PG were found to mediate, in part, the ...
Uterine and Serum Glycodelin Concentration in Recurrent Implantation Failure Versus Normal Fertile Women on Implantation Window. Robabeh Taheripanah1 , Marzieh Zamaniyan2* , Shahrzad Akhoondzadeh1 , Anahita Taheripanah3 , Narges Malih4. Abstract Objectives: Glycodelin is a factor which regulates immunological activity and is required in implantation window. The present study was conducted to compare glycodelin concentrations in blood and uterine flushing samples from women with in vitro fertilization (IVF) failure and fertile controls. Materials and Methods: This was a prospective clinical trial including 20 women with IVF failure and 19 fertile participants. Both groups initially filled a special questionnaire including their demographic profile and prior failed IVF attempts. Then samples of uterine flushing and blood samples were taken to measure glycodelin concentrations. Results: There were significant differences between mean glycodelin concentrations in the case and control groups, both in ...
An anti-wrinkle cell revitalizer, reducing inflammation + repairing damaged cells. The newest bio-placenta + growth factor peptides; promoting, supporting + prompting increased, noticeably firmer, smother skin regeneration + strength. ...
Elif Nur Firat-Karalars studies have taken her from Turkey to the USA and back again, where she is now Assistant Professor at Koç University in Istanbul, focusing on the structure and function of the mammalian centrosome/cilium complex.. Catch up with early-career first authors in our First Person interviews. Recently, we spoke to Min Jae Kim, Osvaldo Contreras and Ebtissal Khouj.. ...
Pregnant women beware - if you eat genetically modified organism or the GMO foods, you may be exposing your unborn baby to dangerous toxins.
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Numerous studies have established the association between an elevated sFlt-1/PlGF ratio and preeclampsia (5, 10, 11, 46-49). However, whether this biochemical imbalance is directly related to disease etiology remains largely unknown. We studied mice with genetic deletion of PlGF to address whether the resultant angiogenic factor imbalance would be sufficient to induce preeclampsia. We found that pregnant PlGF KO mice displayed an abnormally elevated level of circulating sFlt-1, but lacked manifestations of preeclampsia, in contrast with mice lacking COMT, despite a mean serum concentration of sFlt-1 that was greater than peak concentrations observed in human preeclampsia and in other rodent models of preeclampsia (10, 11). Upregulation of placental Flt-1 and sFlt-1 receptors was presumed to occur in response to ligand depletion. Notably, loss of placental PlGF in the COMT KO preeclampsia model ameliorated the maternal hypertension phenotype of those mice. Furthermore, deletion of PlGF altered ...
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Tumors need blood, and they secrete angiogenic molecules such as vascular endothelial growth factor (VEGF) to encourage new blood vessels to form. Although an antibody directed against VEGF (αVEGF) can prolong life when given in conjunction with chemotherapy to individuals with certain cancers, inhibiting VEGF signaling can elicit adverse side effects and switch on alternative angiogenic mechanisms in tumor cells. Noting that placental growth factor (PlGF, a VEGF family member) is not required for normal development of the vasculature but has been implicated in pathological angiogenesis, Fischer et al. investigated the effect on tumors of an antibody directed against PlGF (αPlGF). In a mouse model, αPIGF by itself inhibited the growth or metastasis of melanoma and of colon and pancreatic carcinomas, and enhanced inhibition of tumor growth by the chemotherapeutic agents gemcitabine and cyclophosphamide, as well as the anticancer effects of an antibody directed against the VEGF receptor ...
Alere Inc. is pleased to announce the results of a study, presented today at the 20th FIGO World Congress of Obstetrics and Gynecology, which demonstrate that a simple blood test measuring placental growth factor (PlGF) can help to quantify risk in women when pre-eclampsia is first suspected. The level of PlGF in blood is already known to be an important marker for placental and foetal wellbeing as well as the placentas ability to sustain the pregnancy.
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Endometrial cells from the uteri of pregnant and nonpregnant cattle were cultured. The presence of one or both of two viruses, noncytopathic mucosal disease virus and bovine syncytial virus, was demonstrated in seven of 19 endometria investigated. It was necessary to subculture the cells an average of four times to detect the viral infections. Difficulties were encountered in producing endometrial cell cultures from cows at term or near the end of term and also from older animals. The infections detected may be significant because both of the viruses isolated are capable of infecting the bovine fetus in utero and mucosal disease virus has been associated with bovine fetal diseases.
Purpose:In recent years, immune therapeutic strategies against non-small cell lung cancer (NSCLC) based on tissue-derived biomarkers, for example PD1/PD-L1 (CD274), have evolved as novel and promising treatment options. However, the crosstalk between tumor and immune cells is poorly understood. Glycodelin (gene name PAEP), initially described in the context of pregnancy and trophoblastic implantation, is a secreted immunosuppressive glycoprotein with an as-of-yet largely unknown function in lung cancer. Experimental Design:In this study, we characterized the expression and role of glycodelin in NSCLC through mRNA and protein expression analyses, functional knockdown experiments and correlations with clinicopathological parameters. Results:Glycodelin mRNA expression was significantly elevated in tumors (n=336) compared with matched normal tissue (p,0.0001). Overall survival was significantly reduced in NSCLC with high glycodelin mRNA levels in women but not in men. Glycodelin was detected in the ...
Free Online Library: Do captured viral genes make human pregnancies possible? by Science News; Science and technology, general Bacteriophages Genetic aspects Biologists Research Pregnancy proteins Viral genetics
PLGF1 Human Recombinant (21-221 a.a.) produced in E.Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 129 amino acids.