Background/Purpose: Autoimmune conditions are associated with an increased risk of adverse pregnancy complications and outcomes, suggesting that pregnancy complications may mediate the excess risk. We performed a causal mediation analysis to quantify the mediated effects of autoimmune conditions on adverse pregnancy outcomes.. Methods: We queried a retrospective California birth cohort created from linked birth certificates and hospital discharge summaries. From 2,963,888 births, we identified women with rheumatoid arthritis, systemic lupus erythematosus, psoriasis and inflammatory bowel disease. Pregnancy complications included preeclampsia/hypertension, gestational diabetes and infection in pregnancy. Adverse pregnancy outcomes were preterm birth, cesarean delivery and small for gestational age. We performed a causal mediation analysis to estimate the total effects of each autoimmune condition and adverse pregnancy outcome, and the indirect effects of each pregnancy complication.. Results: ...
How to Cite: Tennakoon, V., Weerasekera, D.S. and Yasawardene, S.G., 2012. Successful pregnancy outcomes following in-vitro fertilization in infertile couples with high levels of antisperm antibodies. Sri Lanka Journal of Obstetrics and Gynaecology, 32(2), pp.47-48. DOI: http://doi.org/10.4038/sljog.v32i2.3981 ...
TY - JOUR. T1 - Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes. AU - Jensen, Dorte. AU - Lauridsen, Lars Korsholm. AU - Ovesen, Per Glud. AU - Beck-Nielsen, Henning. AU - Moelsted-Pedersen, Lars. AU - Westergaard, Jes G. AU - Moeller, Margrethe. AU - Damm, Peter. PY - 2009/6/1. Y1 - 2009/6/1. N2 - To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality).. AB - To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality).. U2 - 10.2337/dc08-2061. DO - 10.2337/dc08-2061. M3 - Journal article. VL - 32. SP - 1046. EP - 1048. JO - International Journal of MS Care. JF - International Journal of MS Care. SN - 1935-5548. IS - 6. ER - ...
Although the general statistical advice is to keep continuous exposure variables as continuous in statistical analyses, categorisation is still a common approach in medical research. In a recent paper from the Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study, categorisation of body mass index (BMI) was used when analysing the effect of BMI on adverse pregnancy outcomes. The lowest category, labelled underweight, was used as the reference category. The present paper gives a summary of reasons for categorisation and methodological drawbacks of this approach. We also discuss the choice of reference category and alternative analyses. We exemplify our arguments by a reanalysis of results from the HAPO paper. Categorisation of continuous exposure data results in loss of power and other methodological challenges. An unfortunate choice of reference category can give additional lack of precision and obscure the interpretation of risk estimates. A highlighted odds ratio (OR) in the HAPO study is the OR
TY - JOUR. T1 - A description of the methods of the Nulliparous Pregnancy Outcomes Study. T2 - Monitoring mothers-to-be (nuMoM2b). AU - Haas, David. AU - Parker, Corette B.. AU - Wing, Deborah A.. AU - Parry, Samuel. AU - Grobman, William A.. AU - Mercer, Brian M.. AU - Simhan, Hyagriv N.. AU - Hoffman, Matthew K.. AU - Silver, Robert M.. AU - Wadhwa, Pathik. AU - Iams, Jay D.. AU - Koch, Matthew A.. AU - Caritis, Steve N.. AU - Wapner, Ronald J.. AU - Esplin, M. Sean. AU - Elovitz, Michal A.. AU - Foroud, Tatiana. AU - Peaceman, Alan M.. AU - Saade, George R.. AU - Willinger, Marian. AU - Reddy, Uma M.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Objective The primary aim of the "Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be" is to determine maternal characteristics, which include genetic, physiologic response to pregnancy, and environmental factors that predict adverse pregnancy outcomes. Study Design Nulliparous women in the first trimester of pregnancy were recruited into an ...
There are two very common concerns for couples that are considering in vitro fertilization: Unhealthy embryos result in failed pregnancies, which can lead to frustration, extra cost and even depression for IVF couples and multiple embryo transplants increase the risk of complications for both mother and baby. With more and more couples seeking out the assistance of in vitro fertilization to achieve pregnancy, researchers have been looking for more ways to help improve the outcomes of those pregnancies. A new technology known as Eeva (Early Embryo Viability Assessment) may soon help with both of these concerns.. The new technology, shared by a team of investigators at the Pacific Fertility Center (USA) and at the Hewitt Fertility Center in Liverpool (UK) at Fertility 2013, will hopefully result in more favorable pregnancy outcomes and reduce the requirement to move more than one embryo at a time into the womb. This would reduce the number of multiple pregnancies, which have been cited as one of ...
The haemodynamic changes of pregnancy can have a negative impact on maternal cardiac health, especially in women with pre-existing cardiac disease. In the most recent Confidential Inquiries into Maternal Mortality in the United Kingdom, heart disease was found to be the most common indirect cause of maternal death during pregnancy.1 Pregnancy counselling and management for women with heart disease is being increasingly recognized as an important aspect of their overall cardiac care. With increasing awareness, there has been a growing body of research focused on pregnancy outcomes and risk stratification. There have also been new initiatives to improve clinical care, such as the 2011 European Society of Cardiology (ESC) guidelines on the management of cardiovascular disease during pregnancy.2 While our current understanding of pregnancy risk assessment and management has improved over the past 20 years, many questions can only be answered by collaborative efforts. ...
The existing research on pregnancy outcomes for women with intellectual and developmental disabilities (IDD) is sparse. This study analyzed the 2010 Healthcare Cost and Utilization Project Nationwide Inpatient Sample and compared deliveries among women with IDD (n = 340) to the general obstetric population. Women with IDD had longer hospital stays and were more likely to have Caesarean deliveries in contrast to other women. Rates of adverse pregnancy outcomes were elevated for women with IDD across a range of measures, including early labor, preterm birth, and preeclampsia, and their infants were more likely to have low birth weight, even after adjusting for age, race, ethnicity, and insurance type. Targeted interventions are needed to address these deleterious outcomes.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease (U10) NOT-HL-12-154. NHLBI
Adverse pregnancy outcomes (APOs)-including pre-term birth, pre-eclampsia, and intrauterine growth restriction-are common interrelated disorders caused by placental dysfunction and maternal vascular abnormalities (endothelial activation, inflammation, and vasospasm) that occur in approximately 10% to 20% of pregnancies. Women who experience APOs are at increased risk for future cardiovascular disease (CVD). APOs are associated with increased risk of development of hypertension, left ventricular hypertrophy/dysfunction, vascular dysfunction, and renal dysfunction. The vascular abnormalities that are present during an APO also underlie common, difficult-to-treat forms of CVD in women as they age (e.g., cardiac microvascular dysfunction, heart failure with preserved ejection fraction), suggesting shared mechanistic pathways for APOs and CVD. Here, the authors synthesize the current information and knowledge gaps regarding the progression from APO to CVD. Understanding the risk factors for and ...
Inkster , M E , Fahey , T P , Donnan , P T , Leese , G P , Mires , G J & Murphy , D J 2006 , Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus : systematic review of observational studies , BMC Pregnancy and Childbirth , vol. 6 , 30 . https://doi.org/10.1186/1471-2393-6- ...
In this study, women with AS showed higher risk for CS than those without AS, but other maternal and foetal outcomes were comparable, including LBW, after adjusting for the number of foetuses.. The results of the present study are in line with the aforementioned studies of AS and pregnancy. The previous retrospective case-control study with 20 pregnant women with AS demonstrated that pregnancy outcome of patients with AS was not different from that of healthy control subjects, except for older maternal age and higher rate of female foetuses in women with AS [17]. In addition, in the retrospective study involving 12 pregnant women with AS, pregnancy outcome was not significantly affected by the disease [18]. Similarly, a retrospective study including a cohort of 939 patients from the AS International Federation Societies in USA, Canada and Europe showed favourable pregnancy and neonatal outcomes in women with AS [19]. However, a recent nationwide population-based case-control study in Sweden was ...
Introduction: Although numerous studies have depicted the association between adverse pregnancy outcomes and the future fertility status, this relationship has not b...
Periodontitis and Adverse Pregnancy Outcomes Oral Health and General Health - What are the Connections? Continuing Education Course dentalcare.com
The study showed that the risk of premature birth, microcephaly, and hyperemesis was higher for women with ED of any type. Any form of ED increased the risk of premature delivery with the highest risk for women with anorexia nervosa (60%), followed by unspecified ED (40%) and bulimia (40%). The risk of very preterm birth was highest in bulimia, at 70%, but all three subtypes had a 70% to 90% increased risk of induced preterm birth for medical reasons rather than spontaneous preterm birth ...
Atul Kumar Singh, Anurag Srivastava, M Dabral, SB Gupta.Assessment of the effect of Antenatal checkups and IFA supplementation on pregnancy outcome.NATIONAL JOURNAL OF MEDICAL AND ALLIED SCIENCES 2012;1(1):6-10 ...
HSS releases study findings regarding women with lupus and good pregnancy outcomes., Pioneering Study Finds Most Women with Lupus can Have Good Pregnancy Outcomes, Identifies Risk Factors Linked to Poor Outcomes
Promising research led by investigators at Hospital for Special Surgery may offer hope for women with lupus who once thought that pregnancy was too risky.
Many studies have investigated factors, often in relative isolation from confounders, and usually in association with adverse pregnancy outcome. We are not aware of any studies using a similar approach to that employed in the present study. Previous evidence of an association between a factor and adverse outcome cannot be extrapolated to indicate that the same variable reduces the likelihood of an uncomplicated pregnancy, but it may support biological plausibility. For example, (lower) maternal age was not included in the final list of variables associated with uncomplicated pregnancy in our study, despite many studies linking advanced maternal age to adverse pregnancy outcomes.14 15 Although it might seem intuitive that improvable factors related to diet, blood pressure, heart rate, weight, and smoking would predict uncomplicated pregnancy, the evidence from well conducted prospective cohort studies has been lacking to date.. The association between obesity and adverse perinatal outcome has ...
Adverse birth outcomes are associated with infant morbidity and mortality and with an increased likelihood of type 2 diabetes, hypertension, and cardiovascular disease in adulthood. Socioeconomic status (SES) is one of the most reliable predictors of health disparities, and although the association between SES and birth outcomes has been studied previously, this is, to our knowledge, the first review that encompasses several dimensions of SES and their influence on birth outcomes in a single article. Our review indicates that education, income, neighbourhood SES, and occupation ...
I always say its never over til the fat lady sings. But that doesnt mean I cant see that fat lady getting ready to get on stage...I can also hear her warming up, running through a few scales too. So, my suspicions were pretty much confirmed about why I didnt get my results yesterday. My results were…
While antiretroviral therapy in pregnancy reduced vertical transmission, it also increased the frequency of several adverse birth outcomes compared with ...
Centers for Disease Control and Prevention. Another cool fact. Your first twins ultrasound is usually achieved at about 12 weeks; you might have a ;re-pregnancy earlier for various reasons one being to verify gestation. The primary 13 weeks are often called the First Trimester. These being pregnant tests are very sensitive and really accurate, a positive take a look at means you are definitely childbirth educator certification canada. Be sure to talk to your healthcare provider pregnancyy the possible uncomfortable side effects and complications of the kind of process youll have. i am precisely the identical i am 17 weeks tmoz imporve im hardly displaying, am undecided if i have observed a distinction in my breats both sounds mad however i am small chested. I had these for bout 2 weeks now and when I do bleed its gentle. Participation on this website by a party does pre-pregnancy nutrition can improve pregnancy outcomes imply endorsement of another social gatherings content, merchandise, or ...
In an earlier publication, it was shown that consumption of tapwater during the first trimester of pregnancy was associated with a risk of spontaneous abortion among women who attended three prenatal clinics located in northern California between September 1981 and June 1982. Evidence for biased recall was presented. This report demonstrates that the association is limited to women interviewed by telephone and is not observed among those who completed a mail questionnaire. The possibility that the association among women interviewed by telephone is causal and that the lack of association among mail respondents is due to bias, confounding, or apparently chance fluctuations is shown to be unlikely. For instance, the probability is low that, among mail respondents, cases underreported exposure as compared with controls or that random errors were common enough to camouflage a true effect. Demographic differences between mail and telephone respondents also do not explain the results. Interviewers ...
As the authors acknowledge, information about disease activity, which is a key variable in the equation of the choice of therapy and outcomes of mother and child, was not recorded; further commentary regarding its impact on the different outcomes of the groups is merited. It is reasonable to hypothesize that patients may be receiving a thiopurine owing to more severe disease, and that this disease severity may also affect pregnancy outcomes. In fact, what was not measured may count as much as what was accounted for in the cohort. Disease activity has been related to birth outcomes and is a factor in therapy choice, and thus a confounder, by definition, of the differences found between the groups. Therefore, the lack of a difference in pregnancy and fetal outcomes in the three groups of patients with IBD does not necessarily mean that thiopurines are not independently associated with adverse outcomes. However, one would suspect that women with more severe disease activity would be in one of the ...
Handler, A. and Rosenberg, D. (1992), Improving Pregnancy Outcomes: Public Versus Private Care for Urban, Low-Income Women. Birth, 19: 123-130. doi: 10.1111/j.1523-536X.1992.tb00669.x ...
Communications Director, AgriSafe Network. Pregnancy and fertility are often not considered when women assume farm tasks. Pesticide and other chemical exposures, zoonotic diseases and heavy lifting particularly during childbearing years, present challenges. ...
Pathak, Sangeeta (2010) Morphological and histological placental characteristics in relation to pregnancy outcome in an unselected population. Doctoral thesis, University of East Anglia. ...
A study led by Hospital for Special Surgery researchers has demonstrated that women who have a specific type of antibody that interferes with blood vessel function are at risk for adverse pregnancy outcomes and that other ...
SYDNEY, AUSTRALIA - Women at high risk of early preeclampsia who show signs of abnormal hemodynamic function earlier in pregnancy may be more likely to have adverse pregnancy outcomes, new data suggest.
(2013) Edvardsson et al. BMC Public Health. BACKGROUND: Overweight and obesity in pregnancy increase the risk of several adverse pregnancy outcomes. However, both mothers and fathers health play an important role for long-term health outco...
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Background: Placental malaria (PM) causes adverse pregnancy outcomes in the mother and her foetus. It is difficult to study PM directly in humans due to ethical challenges. This study set out to bridge this gap by determining ...
Periodontal diseases affect the majority of the population either as gingivitis or periodontitis. Recently there have been many studies that link or seek to find a relationship between periodontal disease and other systemic diseases including, cardiovascular disease, diabetes, stroke, and adverse pregnancy outcomes. For adverse pregnancy outcomes, the literature is inconclusive and the magnitude of the relationship between these 2 has not been fully decided. The goal of this paper is to review the literature regarding periodontal diseases and adverse pregnancy outcomes, and provide oral health care providers with resources to educate their patients. Alternatively, this paper will also discuss what is occurring to help increase the availability of care for pregnant women and what oral health care providers can do to help improve these issues.. ...
Gender is known to influence pregnancy outcomes. Recent studies have reported an association between air pollution exposure and adverse pregnancy outcomes, but gender differences have not been considered. In order to assess the current evidence of the interactive effects between gender and air pollution on pregnancy outcomes we undertook a systematic literature review. Using a comprehensive list of keywords, English language articles published between 1966 and 2005 were retrieved from major databases. Additional information on gender was obtained from the study authors. Studies were included if they contained well-defined measurements of ambient air pollutants, investigated pregnancy outcomes and reported estimates by gender. In total 11 studies were included. The quality of the studies was assessed using the framework in Systematic Reviews in Health Care Meta-analysis in context and Brackens Guidelines. Of the 11 studies, four evaluated low birth weight (LBW); one each evaluated very low birth ...
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) established the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) to study women for whom the current pregnancy will lead to their first delivery (nulliparas). About 40% of pregnant women in the United States are nulliparas. Because little or no information from previous pregnancy outcomes is available to guide assignment of risk or mitigating interventions, adverse pregnancy outcomes in nulliparas are especially unpredictable. The underlying mechanisms of adverse pregnancy outcomes such as preterm birth, preeclampsia, fetal growth restriction and stillbirth are interrelated and therefore will be evaluated as part of this study. The information gained will benefit women who are pregnant or who are considering pregnancy and their physicians. In addition, the knowledge will support future research aimed at improving care and health outcomes for a critical group of at-risk women who ...
Background: Smoking habit acts as the risk factor for Periodontal disease and Adverse pregnancy outcomes. Mild maternal smoking might also cause whopping adverse pregnancy outcomes. Lack of awareness in pregnant woman regarding the adverse outcome of pregnancy with maternal smoking is very common in developing countries like India. The objective of this study was to evaluate knowledge and awareness of south Indian pregnant female about maternal smoking and its association with adverse pregnancy outcomes. Materials and Methods: Multiple optioned 21 questionnaires was prepared with four categories i.e about smoking habit, stress levels, smoking effects on pregnancy outcomes, and discontinuing the habit. Maternal smoking also related with stress levels. Questionnaire forms were distributed to 440 pregnant patients who visited primary health centers in primary health care centers in several parts of south India. Answers were evaluated based on the current evidence available. Results: Most of the ...
TY - JOUR. T1 - Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement. AU - Sugiura-Ogasawara, Mayumi. AU - Aoki, Koji. AU - Fujii, Tomoyuki. AU - Fujita, Tomio. AU - Kawaguchi, Rie. AU - Maruyama, Tetsuo. AU - Ozawa, Nobuaki. AU - Sugi, Toshitaka. AU - Takeshita, Toshiyuki. AU - Saito, Shigeru. PY - 2008/7/1. Y1 - 2008/7/1. N2 - Information concerning the prognosis of subsequent pregnancies in patients with reciprocal translocations is limited. This study was performed to determine the percentage success rate with first pregnancies after ascertainment of a carrier status. A total of 2,382 couples with a history of two or more consecutive miscarriages were studied in multicenters. The prevalence of an abnormal chromosome in either partner was examined, and subsequent success rates were compared between cases with and without an abnormal karyotype in either partner. A total of 129 couples (5.4%) had an abnormal ...
TY - JOUR. T1 - Preconceptional cardiovascular health and pregnancy outcomes in women with systemic lupus erythematosus. AU - Eudy, Amanda M.. AU - Siega-Riz, Anna Maria. AU - Engel, Stephanie M.. AU - Franceschini, Nora. AU - Howard, Annie Green. AU - Clowse, Megan E.B.. AU - Petri, Michelle. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Objective. To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE). Methods. The study included patients in the Hopkins Lupus Pregnancy Cohort. Body mass index (BMI), total cholesterol, and blood pressure (BP) in the most recent clinic visit prior to conception or first trimester were used to determine CV health (ideal, intermediate, or poor health) based on AHA definitions. Outcomes included preterm birth, gestational age at birth, and small for gestational age (SGA). Multivariable linear and logistic regression models with ...
non viable pregnancy - MedHelps non viable pregnancy Center for Information, Symptoms, Resources, Treatments and Tools for non viable pregnancy. Find non viable pregnancy information, treatments for non viable pregnancy and non viable pregnancy symptoms.
Time-to-pregnancy (TTP) has never been studied in an African setting and there are no data on the rates of adverse pregnancy outcomes in South Africa. The study objectives were to measure TTP and the rates of adverse pregnancy outcomes in South Africa, and to determine the reliability of the questionnaire tool. The study was cross-sectional and applied systematic stratified sampling to obtain a representative sample of reproductive age women for a South African population. Data on socio-demographic, work, health and reproductive variables were collected on 1121 women using a standardized questionnaire. A small number (n = 73) of randomly selected questionnaires was repeated to determine reliability of the questionnaire. Data was described using simple summary statistics while Kappa and intra-class correlation statistics were calculated for reliability. Of the 1121 women, 47 (4.2%) had never been pregnant. Mean gravidity was 2.3 while mean parity was 2.0 There were a total of 2467 pregnancies; most (87%)
Authors: B Bello, D Kielkowski, D Heederik, K Wilson.. Source: BMC Public Health 2010, Sept 21; 10:565.. Summary:. Background: Time-to-pregnancy (TTP) has never been studied in an African setting and there are no data on the rates of adverse pregnancy outcomes in South Africa. The study objectives were to measure TTP and the rates of adverse pregnancy outcomes in South Africa, and to determine the reliability of the questionnaire tool.. Methods: The study was cross-sectional and applied systematic stratified sampling to obtain a representative sample of reproductive age women for a South African population. Data on socio-demographic, work, health and reproductive variables were collected on 1121 women using a standardized questionnaire. A small number (n = 73) of randomly selected questionnaires was repeated to determine reliability of the questionnaire. Data was described using simple summary statistics while Kappa and intra-class correlation statistics were calculated for ...
In 2001-2008, 2.9% of pregnant North Carolina women were drivers in one or more crashes. After a single crash, compared to not being in a crash, pregnant drivers had slightly elevated rates of preterm birth and premature rupture of the membranes. Following a second or subsequent crash, pregnant drivers had more highly elevated rates of preterm birth, premature rupture of the membranes and stillbirth. Stillbirth rates were elevated following crashes involving unbelted pregnant drivers compared to belted pregnant drivers ...
New England Journal of Medicine March 30, 2017 Vol. 376 No. 13 http://www.nejm.org/toc/nejm/medical-journal Original Article Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes Nikolai M. Scheller, M.D., Björn Pasternak, M.D., Ph.D., Ditte Mølgaard-Nielsen, M.Sc., Henrik Svanström, Ph.D., and Anders Hviid, Dr.Med.Sci. N Engl J Med 2017; 376:1223-1233 March 30, 2017 DOI: 10.1056/NEJMoa1612296 Abstract…
TY - JOUR. T1 - The epidemiology of pregnancy outcomes in rural Burkina Faso. AU - Bell, Jacqueline S.. AU - Ouedraogo, Moctar. AU - Ganaba, Rasmane. AU - Sombie, Issiaka. AU - Byass, Peter. AU - Baggaley, Rebecca F.. AU - Filippi, Veronique. AU - Fitzmaurice, Ann E.. AU - Graham, Wendy J.. PY - 2008/7. Y1 - 2008/7. N2 - Objectives To describe levels and causes of pregnancy-related mortality and selected outcomes after pregnancy (OAP) in two districts of Burkina Faso.Methods A household census was conducted in the two study districts, recording household deaths to women aged 12-49 years from 2001 to 2006. Questions on pregnancy outcomes in the last 5 years for resident women of reproductive age were included, and an additional method - direct sisterhood - was added in part of the area. Adult female deaths were followed-up with verbal autopsies (VA) with household members. A probabilistic model for interpreting VA data (InterVA-M) was used to determine distributions of probable causes of death. ...
Design - Comparative study of pregnancy outcome for parturients who had stayed in an antenatal village and for those admitted directly from the community. Setting - A rural hospital in Zimbabwe. Outcome measures - Birthweight, perinatal mortality and degree of obstetrical intervention. Results - Women who stayed in the antenatal village experienced better pregnancy outcome than women admitted directly from the community. Birthweight was greater, perinatal mortality lower, and obstetrical intervention less often required in the antenatal village group. Conclusions - Lack of randomisation, differences between the two groups in antenatal risk factors, and lack of information relating to socio-economic status suggest that generalisations beyond the specific case be made cautiously.
To study the effect of endometrial thickness and pattern measured using ultrasound upon pregnancy outcomes in patients undergoing IVF-ET. One thousand nine hundred thirty-three women undergoing IVF treatment participated in the study. We assessed and recorded endometrial patterns and thickness on the day of human chorionic gonadotropin (hCG) administration. Receiver operator curves (ROC) were used to determine the predictive accuracy of endometrial thickness. Cycles were divided into 3 groups depending on the thickness (group 1: ≤ 7 mm; group 2: | 7 mm to ≤ 14 mm; group 3: | 14 mm). Each group was subdivided into three groups according to the endometrial pattern as follows: pattern A (a triple-line pattern consisting of a central hyperechoic line surround by two hypoechoic layers); pattern B (an intermediate isoechogenic pattern with the same reflectivity as the surrounding myometrium and a poorly defined central echogenic line); and pattern C (homogenous, hyperechogenic endometrium). Clinical
Sponsor. National Institutes of Health (NIH). Principal Investigator. Dr. Hazel Nichols, Epidemiology. Project Run Dates. 7/01/2017 to 6/30/2022. Summary. In the U.S., more than 45,000 women are diagnosed with cancer during adolescence and young adulthood (AYA, ages 15-39 at diagnosis) each year. Fertility and reproductive outcomes are critical issues for AYA cancer survivors but little is known about the effect of diagnosis and treatment on the clinical course and outcome of future pregnancy. Our study will leverage existing data sources to assess clinical pregnancy outcomes among women with the most common AYA cancers (lymphoma, breast, melanoma, thyroid and gynecologic cancer) that account for ,70% of all diagnoses. Our findings will provide urgently needed answers that can be directly applied to fertility preservation, preconception, and prenatal counseling.. Data for this study come from the Kaiser Permanente (KP) Northern and Southern California integrated healthcare systems and from an ...
Results: Of 364,363 singleton pregnancies resulting in live or stillbirths 1,969 (0.5%) were in women with IBD. Women with CD were more likely to have pre-term births (OR=1.42 95%CI;1.12-1.79), babies with low birth weights (OR=1.39;1.05-1.83) and postpartum haemorrhage (OR=1.27;1.04-1.55) whereas women with UC were only at increased risk of pre-term births with an absolute risk difference of ,2.7%. These risks remained independent of caesarean section (CS). Prior surgery for IBD did not increase risk of adverse birth outcomes or pregnancy related complications compared to cases without surgery, however women with IBD were more likely to have an elective CS ...