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Pharmaceutical Powder X-ray Diffraction Symposium - PPXRD-2, December 9-12, 2002 NOTE: The schedules and guidelines in this area of the ICDD website are left here for archival purposes. The ICDD is pleased to present the second symposium on Pharmaceutical Powder X-ray Diffraction, December 9-12, 2002 in Concordville, PA, U.S.A. PPXRD-2 focused on topics of interest to scientists and engineers in the pharmaceutical industry using powder x-ray diffraction. The ICDD hopes to create a forum for these two fields to discuss latest developments, exchange ideas and gain knowledge from valuable lectures all surrounding the XRD and pharmaceutical industries. ...
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Flowability that quantifies the flow behaviour of powders is an important material attribute for such applications as packing, hopper flow and powder transport. It is also one of the critical material attributes of pharmaceutical formulations for solid dosage forms. It is anticipated that size enlargement via dry/wet granulation will improve the flowability of feed powders, but it is still unclear how significant the flowability can be enhanced. Therefore, in this study, an experimental investigation was performed to explore how dry granulation affects the flowability of pharmaceutical powders, such as microcrystalline cellulose (MCCs), mannitol and lactose. Both as-received powders and binary mixtures were considered. Granules of various sizes were produced using roll compaction followed by ribbon milling, and the flowability of as-received powders and produced granules was characterised using two methods: 1) the critical filling speed measured using a model die filling system and 2) the flow ...
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A concentrate/extract cartridge for a beverage dispenser adapted to dispense a liquid concentrate/extract and a diluent is provided. The cartridge includes a hollow body for containing liquid concentrate/extract and an aperture. A pumping device is connected to the hollow body for dispensing the liquid concentrate/extract from the hollow body through the aperture. A method for dispensing a liquid concentrate/extract from a beverage dispenser using a concentrate/extract cartridge is also provided in which the concentrate/extract does not come into contact with the dispenser.
1. A dry powder formulation for use in a dry powder inhaler, comprising: (a) a fraction of fine particles made of a mixture comprising 90 to 99.5 percent by weight of particles of a physiologically acceptable excipient and 0.5 to 10 percent by weight of magnesium stearate, said mixture having a mass median diameter lower than 20 microns; (b) a fraction of coarse particles comprising a physiologically acceptable excipient having a mass median diameter equal to or higher than 100 microns, wherein the weight ratio between said fine particles and said coarse particles is 1:99 to 30:70 percent by weight; and (c) formoterol fumarate dihydrate in combination with beclometasone dipropionate (BDP) as active ingredients both in the form of micronized particles; wherein: (i) no more than 10% of said BDP particles have a volume diameter lower than 0.6 microns; (ii) no more than 50% of said BDP particles have a volume diameter of 1.5 microns to 2.0 microns; and (iii) at least 90% of said BDP particles have a ...
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Taking advantage of the differences between the interactions of transversely excited atmospheric (TEA) CO,sub,2,/sub, lasers with metal and with organic powder, a new technique for the direct analysis of food powder samples has been developed. In this technique, the powder samples were placed into a small hole with a diameter of 2 mm and a depth of 3 mm and covered by a metal mesh. The TEA CO,sub,2,/sub, laser (1500 mJ, 200 ns) was focused on the powder sample surfaces, passing through the metal mesh, at atmospheric pressure in nitrogen gas. It is hypothesized that the small hole functions to confine the powder particles and suppresses the blowing-off of sample, while the metal mesh works as the source of electrons to initiate the strong gas breakdown plasma. The confined powder particles are then ablated by laser irradiation and the ablated particles move into the strong gas breakdown plasma region to be atomized and excited; this method cannot be applied for the case of Nd:YAG lasers because ...
Powder handling is a common operation found in several industrial processes like storage, feeding, fluidization, blending, compaction etc. where powders are used as raw materials, intermediates, or final products. Oftentimes, handling and working with powders can be quite difficult and challenging owing to their change in behavior during manufacturing processes, mostly resulting from changes in powder particle size. Unexpected changes and poorly characterized size of powders can have an enormous impact on the quality of the final product.. A number of technologies exist for particle sizing that encompasses powder sampling and analysis in a dry or wet state. We present, in this webinar, the widely used technologies of Dynamic Light Scattering (DLS) and Laser Diffraction (LD) to reliably determine particle size. This webinar will discuss the theory behind these measurement techniques and present some examples from particle size measurements on powders both in the dry and wet state. Date: ...
Studies have been performed to characterize the flow of certain powders of pharmaceutical interest from a vibrating spatula. Lactose, cromolyn sodium, sodium chloride and charcoal powders were prepared by milling or sieving. Jet milling yielded micronized powder (1-10 mum), which was recovered from the product jar or metal cyclone. Particles in the larger size ranges were prepared by sieving. Photomicrograph images of the products were obtained by scanning electron microscopy. All of the powders were subjected to flow studies from vibrating beds to a top loading pan balance.
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Scherließ, R., Inhalativa - Arzneiformen zur lokalen und systemischen Gabe/ Inhaled dosage forms -formulations for local and systemic delivery, Pharmacon, 02/16 (2016). Scherließ, R., Exploring the potential of mannitol as an alternative to lactose in dry powder inhalation, Inhalation (2016) 30-32. Trows, S. and Scherließ, R., Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug Powder Technology 292 (2016) 223-231. Rietscher, R., Schröder, M., Janke, J., Czaplewska, J.A., Gottschaldt, M., Scherließ, R., Hanefeld, A., Schubert, U.S., Schneider, M., Knolle, P. and Lehr, C.-M., Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. EJPB 102 (2016) 20-31. Hertel, M., Littringer, E.M., Hauptstein, S., Dogru, M., Schwarz, E., Scherließ, R. and Steckel, H., The influence of high shear mixing parameters on the performance of ternary dry powder inhaler formulations, Respiratory Drug Delivery 2016, ...
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A method for the surface treatment of a ferromagnetic fine powder is disclosed. The method increases the dispersibility of the powder in a magnetic coating composition. The method comprises subjecting a magnetic composition to a dispersing processing, with the magnetic composition containing (1) a ferromagnetic fine powder, (2) at least one polar compound selected from a group consisting of such compounds as to have one or more of --COOH, --CONH2, --CONH2, --PO3 H, --SO3 H, --OH or --NH2 in a molecule and quaternary ammonium salts, and (3) an organic solvent capable of dissolving the polar compound, and evaporating the organic solvent from the magnetic composition.
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Powder - Micronized Products. Particle size plays an important role in many industries and applications since it influences many properties of particulate materials. It is a valuable indicator of quality and performance. In mining, there are generally three values to define powders in terms of micron size Dv10, Dv50, and Dv90..In a Malvern Mastersizer Result Analysis Report of Particle Size Analyzer the D50 is represent as D0.50 D represents the diameter of powder particles, and D50 means a cumulative 50 point of diameter or 50 pass particle size D10 means a cumulative 10 point of diameter D50 is also called average particle size or median diameter D 4, 3 means volume mean diameter, and D 3, 2 means ....Jul 25, 2012 Powder flow behaviour can affect manufacturing efficiency and can directly affect product quality variables such as dose uniformity. It is now possible to measure reliably the flow properties of a powder and relate these directly to particle morphology. Accurate, statistically ...
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0006] It has been discovered that dry powder preparations characterised by dose uniformity, reliability and dispersion of medicaments uniformity may be obtained by mixing specified ratios of medicaments to carrier in a specified manner as described herein. Thus, the invention provides a method of preparing a dry powder inhalation composition comprising a pharmaceutically acceptable particulate carrier, a first particulate inhalant medicament and a second particulate inhalant medicament, where the proportion of the second medicament to the carrier is smaller relative to the proportion of the first medicament to the carrier. The method is characterised in that the carrier is mixed with a first portion of the first particulate inhalant medicament, the resulting first mixture is mixed with substantially all of the second particulate inhalant medicament to give a mixture. The remaining portion of the first particulate inhalant medicament is mixed with the second mixture to give the desired dry powder ...
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In this research, the effect of heating rate on oxidation kinetics of magnesium powder particles under non-isothermal conditions was studied. For this purpose, differential thermal analysis (DTA) and thermogravimetry analysis (TGA) was done on magnesium powder particles at three heating rates of 5, 10 and 20 K min-1 up to 1000 ...
A toner for developing electrostatic images includes (a) toner particles having a weight-average particle size of 1-9 μm, (b) hydrophobized inorganic fine powder having an average particle size of 10-90 nm and (c) hydrophobized silicon compound fine powder. The hydrophobized silicon compound fine powder has an average particle size of 30-120 nm, and a particle size distribution such that it contains 15-45% by number of particles having sizes of 5-30 nm, 30-70% by number of particles having sizes of 30-60 nm and 5-45% by number of particles having sizes of at least 60 nm. The hydrophobized silicon compound fine powder having a broad particle size distribution including coarse particles functions to prevent the embedding of the hydrophobized inorganic fine powder (functioning as a flowability improver) from being embedded at the toner particle surfaces, whereby the toner is allowed to exhibit stable performances even in a continuous image formation on a large number of sheets.
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In the present invention, slurry is formed by mixing noble metal-supported powder particles (3) and a binder (4) with each other in a liquid (Step S1), and the noble metal-supported powder particles (3) are dispersed by applying vibrations to the slurry (Step S2), and thereafter, the slurry is spray dried while keeping a state where the noble metal-supported powder particles (3) are dispersed (Step S3), whereby noble metal-supported powder (1) is produced. In the noble metal-supported powder (1) produced by such a method, pores through which exhaust gas flows are formed appropriately, and accordingly, exhaust gas purification performance can be enhanced.
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TY - CONF. T1 - Investigation of fundamental powder flow properties of fine lactose particles following mechanical surface modification. AU - Zhou, Qi. AU - Roberts, Benjamin Armstrong. AU - Morton, David Alexander Vodden. AU - Stewart, Peter James. PY - 2008. Y1 - 2008. M3 - Other. SP - 49. EP - 51. ER - ...
The quality and efficiency of laser-aided direct metal deposition largely depends on the powder stream structure below the nozzle. Numerical modeling of the powder concentration distribution is complex due to the complex phenomena involved in the two-phase turbulence flow. In this paper, the gravity-driven powder flow is studied along with powder properties, nozzle geometries, and shielding gas settings. A 3-D numerical model is introduced to quantitatively predict the powder stream concentration variation in order to facilitate coaxial nozzle design optimizations. Effects of outer shielding gas directions, inner/outer shielding gas flow rate, powder passage directions, and opening width on the structure of the powder stream are systematically studied. An experimental setup is designed to quantitatively measure the particle concentration directly for this process. The numerical simulation results are compared with the experimental data using prototyped coaxial nozzles. The results are found to ...
Investigation into the Influence of Primary Crystallization Conditions on the Mechanical Properties and Secondary Processing Behaviour of Fluticasone Propionate for Carrier Based Dry Powder Inhaler Formulations. Kubavat, Harshal; Shur, Jagdeep; Ruecroft, Graham; Hipkiss, David; Price, Robert // Pharmaceutical Research;Apr2012, Vol. 29 Issue 4, p994 Purpose: To investigate the influence of primary crystallization conditions on the mechanical properties and secondary processing behaviour of fluticasone propionate (FP) for carrier based dry powder inhaler (DPI) formulations. Methods: Youngs modulus of FP crystals produced using different... ...
article{149532, author = {Ameye, Dieter and KELEB, E and Vervaet, Chris and Remon, Jean Paul and ADAMS, E and MASSART, DL}, issn = {0928-0987}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, language = {eng}, pages = {247--251}, title = {Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers.}, volume = {17 (4-5}, year = {2002 ...
GSK2269557 is potent and highly selective inhaled phosphoinositides 3-kinases -delta (PI3K-delta) inhibitor being developed as an anti-inflammatory agent for the treatment of inflammatory airway diseases. GSK2269557 has already been administered as a nebulized solution in single and repeat doses to humans and has been well tolerated across the range of doses used. The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single and repeat inhaled doses of GSK2269557 as a dry powder. This study is the first administration of dry powder GSK2269557 in humans.. Part A will consist of four treatment periods separated by at least 14 days wash out periods. In each treatment period there will be 12 subjects receiving GSK2269557 and 4 subjects receiving placebo. The doses of GSK2269557 planned for Part A are 100 micrograms (mcg), 500 mcg and 3000 mcg. Blinded safety and available pharmacokinetic (PK) data will be reviewed before each dose escalation. Part B will be a ...
This product is sold in HERBAL POWDER form.The net weight of the Herbal Powder is listed with the herb name. Herbal Powders consist of whole herbs that have been dried, sterilized, tested, and then ground into a powder form.Herbal Powders are generally packaged in vacuum-sealed bags.Please note that HERBAL POWDERS cons
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What is a low carb protein powder? A low carb protein powder provides you with a highly concentrated source of protein that avoids using carbohydrates and especially sugars to sweeten or flavor the supplement. Many traditional protein powders or mass gainers rely heavily on carbohydrates as a sweetener or a source of calories. If you are following a keto diet, or if you are trying to keep your carb and sugar intake low, these more traditional protein powders can foul up your plans. Go for a low carb protein powder instead.. Can low carb protein powders help with weight loss? While protein powder should not be used as a meal replacement to lose weight, the addition of a low carb protein powder can both help aid with weight loss.. Can I take low carb protein powder if I am on medication? There are no known interactions between low carb protein powder and medications. If you are consistently taking medications, please consult your doctor before adding any supplements to your diet. Can I use low ...
Aluminium powder is powdered aluminium. This was originally produced by mechanical means using a stamp mill to create flakes. Subsequently, a process of spraying molten aluminium to create a powder of droplets was developed by E. J. Hall in the 1920s. The resulting powder might then be processed further in a ball mill to flatten it into flakes for use as a coating or pigment. Aluminium powder is non-toxic and is not harmful unless injected directly in a major blood vessel such as the aorta[citation needed]. Aluminium powder, if breathed in, is not particularly harmful and will only cause minor irritation. The melting point of aluminum powder is 660 °C. cosmetic colorant pyrotechnic in paints as metallic silver pigment fingerprint powder Rocket and missile fuel thermite refractory Depending on the usage, the powder is either coated or uncoated. Metal powder Technology portal Joseph R. Davies (1993), Powder Metallurgy Processing, Aluminium and Aluminium Alloys, ASM International, p. 275, ISBN ...
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This present invention provides a spray dryer for use in prepg. particles for inhalation, the spray dryer comprising a multi-​nozzle app. comprising multiple single nozzles suitable for use in prepg. inhalation powders and with a drying gas flow rate greater than about 80 kg​/h. Also provided is a method for scaling-​up a spray drying process for prepg. particles for inhalation from a smaller scale spray dryer to a larger scale spray dryer, relative in size to each other, the method comprising the use in the larger scale spray dryer of a multi-​nozzle app. comprising single nozzles suitable for use in prepg. inhalation powders, wherein the no. of nozzles in the larger spray dryer is detd. by the ratio of the drying gas flow rate of the larger scale spray dryer to the drying gas flow rate of the smaller scale spray dryer. Also provided is a multi-​nozzle app. produced from the method of the present invention, the multi-​nozzle app. comprising multiple single nozzles suitable for use ...
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The efficiency rate of a particular powder bed additive manufacturing process, as well as overall component quality, is often dependent on the packing density and flow behaviour of the metal powder particles involved.. Particle size and shape directly influences these properties, and hence are important quality parameters for assessing and grading powders for use in the process.. In this webinar Dr Paul Kippax will discuss the importance of particle size and shape in terms of packing behavior and processing and how these parameters can be measured using Laser Diffraction and Morphological Imaging respectively.. Event summary. ...
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Within the scope of this work a novel process to improve the flowability of fine powders is investigated. Nanoparticles are generated by plasma enhanced chemical vapor deposition (PECVD), and deposited on the surface of the substrate particles. These nanoparticles are acting as spacers between the substrate particles, thus increasing the distance between their surfaces and thereby decreasing the Van-der-Waal forces.|br| |br|To investigate the nanoparticle generation and attachment in the PECVD process, glass beads as a model substrate were treated in a circulating fluidized bed reactor. The influences of varying process parameters like system pressure, gas composition and number of circulations on nanoparticle size distributions were investigated.
Study shows that adequate choice of the blending technique, e.g. using magnesium stearate as an excipient allows control of aerosol performance of a dry powder inhaler.
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Mansour, H., Xu, Z., & Hickey, A. (2007). Characterization of dry powder aerosols of albuterol sulfate and cromolyn sodium with various sugar carriers delivered by standardized entrainment tubes. The AAPS Journal, 9(4), W - 5234 ...
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The pulmonary drug delivery systems market has split into three major segments: metered dose inhalers (MDIs), dry powder inhalers (DPIs) and nebulizers. An MDI is a device that delivers a measured amount of medication to the lungs in the form of a mist. A DPI is a device that delivers a measured amount of medication to the lungs in the form of a dry powder. A nebulizer is a device that delivers a measured amount of medication to the lungs in the form of a fine spray. All of these devices are made up of micro sized components. You can see an example of a dry powder inhaler on our Micro Molding/Projects page.. ...
TY - JOUR. T1 - Real-life effectiveness of inhaler device switch from dry powder inhalers to pressurized metred-dose inhalers in patients with asthma treated with ICS/LABA. AU - Park, Hae-Sim. AU - Yoon, Dukyong. AU - Lee, Hyun Young. AU - Ban, Ga-Young. AU - Wan Yau Ming, Simon. AU - Jie, Joanna Ling Zhi. AU - Carter, Victoria. AU - Hardjojo, Antony. AU - Van Boven, Job F M. AU - Price, David B. N1 - © 2019 Asian Pacific Society of Respirology.. PY - 2019/10. Y1 - 2019/10. N2 - BACKGROUND AND OBJECTIVE: Mixed inhaler device use for asthma is associated with worse inhaler technique and outcomes. Given that relievers are commonly prescribed as pressurized metred-dose inhalers (pMDI), changing preventers from dry powder inhalers (DPI) to pMDI may improve asthma outcomes. This study aimed to assess the persistence and effectiveness of switching from DPI to pMDI for inhaled corticosteroid and long-acting β2 -agonist combination therapy (ICS/LABA).METHODS: This was a historical cohort study using ...
Homemade Amla powder is very good for health due to its known 100% percent purity. However, it is not so easy to grind the dried amla pieces as they are hard. Here are some easy ways to make amla powder at home. Grating the amla pieces and drying them helps a lot while making the amla powder at home. Amla can be consumed in many ways. You can preserve amla in honey for easy and pleasing intake. Homemade amla hair oil can be made which can be applied on your hair for promoting hair growth and preventing premature greying. In this article, we will see how to make amla powder at home ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Lidocaine Purity: 99% CAS No: 137-58-6 EINECS: 205-302-8 Appearance: White crystalline powder Tag: Local Anesthetic Powder, Lidocaine Base, Lidocaine HCl Indications and Usage: The efficacy profile of lidocaine as a local anesthetic is...
TY - JOUR. T1 - Preference, satisfaction and errors with two dry powder inhalers in patients with COPD. AU - van der Palen, Jacobus Adrianus Maria. AU - Ginko, Thomas. AU - Kroker, Axel. AU - van der Valk, Paul. AU - Goosens, Martijn. AU - Padulles, Laura. AU - Seoane, Beatriz. AU - Rekeda, Ludmyla. AU - Garcia Gil, Esther. PY - 2013. Y1 - 2013. N2 - Objective: To assess preference, satisfaction and critical errors with a novel, breath-actuated, multi-dose dry powder inhaler (DPI; Genuair®/Pressair™), versus a widely used, single-dose DPI (HandiHaler®) in patients with moderate-to-severe chronic obstructive pulmonary disease. Methods: In this randomised, open-label, multicentre, cross-over study, patients (aged ≥ 40 years) inhaled placebo once daily through both inhalers for 2 weeks in addition to current medication. The primary end point was percentage of patients who preferred Genuair to HandiHaler. Overall patient satisfaction (5-point scale: 1 = very dissatisfied; 5 = very satisfied), ...
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Method for the manufacture by powder metallurgy of shaped parts to be assembled by self-brazing at a specific temperature with receiving metal parts, made from superalloy, said manufacturing method using two metal powders, - a first alloy powder, called the "basic powder" making it possible to obtain the desired metallurgical characteristics and essentially not containing melting element - and a second alloy powder, called the "brazing powder" containing at least one so-called melting element with a content such that the liquidus temperature of the brazing powder alloy is lower than the solidus temperature of the basic powder alloy, said basic and brazing powders being chosen so that the liquidus temperature of the brazing powder is lower than the self-brazing temperature and the solidus temperature of the basic powder is above the self-brazing temperature, - said manufacturing method comprising the following stages: c) preparing of a homogeneous mixture of basic powder, ...
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A process for preparing stable dry powders which are insoluble in hot water and which contain fat-soluble vitamins and/or carotenoids, which comprises the following steps: a) preparing an aqueous dispersion containing essentially these fat-soluble active substances, film-forming colloids and reducing sugars, b) converting this dispersion into dry vitamin and/or carotenoid products in powder form and c) thermally curing the powder at from 60 to 180 C., wherein gelatin in combination with one or more organic amino compounds which are free or bonded in the manner of a salt and which contain a basic primary amino group and, in addition, either another amino group, a hydroxyl group, an alkoxy group or a carboxyl group, and/or in combination with sufficient basic alkali metal or alkaline earth metal compound for the dispersion to have a pH of from 7.5 to 10, is used as film-forming colloid, and the dry powders obtainable via this process are described.
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A unit dose dry powder inhaler has a dispersion chamber, optionally including one or more beads. A blister is supported adjacent to the dispersion chamber. A mouthpiece cover is removable from a mouthpiece, with movement of the mouthpiece cover causing the blister to open. An air flow path extends past or under the blister and into the dispersion chamber. As a result, the blister remains sealed until the inhaler is ready for use. The blister is then automatically opened when the mouthpiece cover is removed from the mouthpiece. Pharmaceutical dry powder is released from the blister and entrained in air flow through the inhaler, when the user inhales on the mouthpiece. The powder is dispersed in air within the dispersion chamber.
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TY - JOUR. T1 - Pulmonary availability of isotretinoin in rats after inhalation of a powder aerosol. AU - Raleigh, S M. AU - Verschoyle, R D. AU - Bowskill, C. AU - Pastorino, U. AU - Staniforth, J N. AU - Steele, F. AU - Dinsdale, D. AU - Carthew, P. AU - Lim, C K. AU - Silvester, J. AU - Gescher, A. N1 - Copyright 2000 Cancer Research Campaign.. PY - 2000/10. Y1 - 2000/10. N2 - Repeated oral administration of chemopreventive retinoids such as isotretinoin over extended periods of time is associated with intolerable systemic toxicity. Here isotretinoin was formulated as a powder aerosol, and its delivery to the lungs of rats was studied with the aim to explore the possibility of minimizing adverse effects associated with its oral administration. Rats received isotretinoin orally (0.5, 1 or 10 mg kg(-1)) or by inhalation (theoretical dose approximately 1 or approximately 10 mg kg(-1)) in a nose-only inhalation chamber. Isotretinoin was quantitated by high-pressure liquid chromatography in plasma ...
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Particle size Distribution D10 is also written as X10, D(0,1) or X(0,1). It represents the particle diameter corresponding to 10% cumulative (from 0 to ) undersize particle size distribution. In other words, if particle size D10 is 7.8um, we can say 10% of the particles in the tested sample are smaller than 7.8 micrometer, or the percentage of particles smaller than 7.8 micrometer is 10% ...A basic guide to particle characterizationsize. Particle size measurement is routinely carried out across a wide range of industries and is often a critical parameter in the manufacture of many products. Particle size has a direct influence on .Crushingreducing Powder Particle SizeParticle Size Analysis - Powder Technology Inc. Particle Size Analysis utilizing a COULTER MULTISIZER IIe or III. The Coulter Principle, also known as ESZ (Electrical Sensing Zone Method), the Multisizer IIe and 3 Coulter Counter provides number, volume, mass and surface area size distributions in one measurement, with an overall ...
In this thesis an investigation into the dependence of the thermal conductivity of a powder on its particle size is described. Measurements of the conductivity of six aluminium powders with interstitial air pressure from atmospheric to 10(^-5) cm. Hg, are reported. The conductivity of a powder is constant at higher pressures until the mean free path of the molecules of the gas becomes comparable to the size of the pore spaces of the powder. The conductivity then decreases with decreasing pressure to a small asymptotic value at low pressures. These results accord with those of previous workers. Measurements of conductivity with varying temperature are also reported and it is concluded that the heat transfer is due to conduction and that convection and radiative heat transfer are not important. The differences in conductivity of the six powders are explained by considering the mean particle size and the porosity of the powders. A finer powder tends to have a low conductivity because a temperature ...
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Talc powder is formed mineral consisting of three main elements magnesium, silicon, and oxygen. Talcum powder works very well in absorbing moisture. This helps keep skin dry and even prevents rashes.. Talcum Powder and Ovarian Cancer. Studies have shown that powder increases the chance of ovarian cancer in women. When the powder is applied to the genital area, it is possible that the particles can travel through the uterus and fallopian tubes to the ovaries. This can cause the formation of ovarian cancer powder.. Certain reports have shown that one out of every 75 women in the US is at risk of developing ovarian cancer in his life.. Talcum Powder Lawsuit. There are about thousands of Talcum Powder Ovarian Cancer Lawsuit - Baby Powder Cancer Lawyers filed against Johnson & Johnson. Lawsuits claim that the manufacturer has failed to notify the user about the risks associated with using the product.. Many users of this product filed lawsuits after developing mesothelioma. Mesothelioma is a disease ...
TY - JOUR. T1 - Combustion of mixtures of industrial aluminum powders with superfine powders of aluminum and aluminum oxide in air. AU - Popenko, E. M.. AU - Ilin, A. P.. AU - Gromov, A. M.. AU - Kondratyuk, S. K.. AU - Surgin, B. A.. AU - Gromov, A. A.. PY - 2002. Y1 - 2002. N2 - Specific features are studied of combustion of mixtures of the industrial aluminum powders ASD-1 and ASD-4 with superfine powders of Al and γ-Al2O3 in air. It is shown that in coarse-dispersed industrial powders combustion, the fixing of air nitrogen takes place with formation of AlN and AlON. The processes of sintering and non-complete combustion are very essential in the combustion of these mixtures.. AB - Specific features are studied of combustion of mixtures of the industrial aluminum powders ASD-1 and ASD-4 with superfine powders of Al and γ-Al2O3 in air. It is shown that in coarse-dispersed industrial powders combustion, the fixing of air nitrogen takes place with formation of AlN and AlON. The processes of ...
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Pearl powder (Chinese: 珍珠粉; pinyin: zhēnzhū fěn) is a preparation of crushed pearls used in China and elsewhere for skin care and in traditional Chinese medicine. Pearl powder is made from freshwater pearls or saltwater pearls below jewellery grade. These are sterilised in boiling water and then milled into a fine powder using stainless steel grinding discs or by milling with small porcelain balls in moist conditions. The powder is sold as such or mixed into creams. Pearl powder is widely believed to help improve the appearance of the skin, and is used as a cosmetic by royal families in Asia. It is also used as a treatment for acne. Some studies have claimed that pearl powder can stimulate the skins fibroblasts, help regenerate collagen, and accelerate healing of certain skin conditions, wounds and burns. Pearl powder contains a number of amino acids, over 30 trace minerals, and a high concentration of calcium. In Chinese medicine, it is used as an anti-inflammatory and detoxification ...
This study presents a metallographic technique that enables the microstructural examination of the cross-sections of individual, fine-scale (10 to 75 μm) powder particles. The technique was developed to permit characterization of the as-solidified features of copperbased powders produced by high-pressure inert gas atomization (HPGA) in order to relate the microstructures to processing history. In order to perform the necessary microscopy to elucidate the microstuctural features, a metallographic technique was developed to permit characterization of the as-atomized microstructures within the individual powder particles. This technique involved classifying, mounting, and polishing through the diameters of individual powder particles and then using an attack etch to remove some of the copper matrix. This enabled characterization of the niobium-rich second phase. Secondary electron imaging on a scanning electron microscope provided the necessary resolution to characterize the second phase ...
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Dry powder inhalers (DPIs) are often used in asthma and chronic obstructive pulmonary disease (COPD) therapies. Using the discrete choice experiment (DCE) methodology, this study conducted in France was designed to assess patients preferences for different attributes of DPIs. Attributes of DPIs were defined based on a literature review, patient focus group discussions and interviews with healthcare professionals (qualitative phase of the study). An online survey was then conducted among French patients with asthma or COPD to elicit patient preferences and willingness to pay (WTP) for these attributes using the DCE methodology (quantitative phase). A fractional factorial design including three blocks of 12 choice sets was created. Each choice set comprised three alternatives: two fictitious inhalers and the patients current inhaler. Marginal utilities were estimated using a ranked ordered logit model. Interactions between attributes and disease (asthma or COPD) were tested. Six DPI attributes were
TY - JOUR. T1 - Influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose with β-cyclodextrin. AU - Wu, J. S.. AU - Ho, H. O.. AU - Sheu, M. T.. PY - 2001. Y1 - 2001. N2 - The individual influence of wet granulation and lubrication on the powder and tableting properties of codried product of microcrystalline cellulose (MCC) with β-cyclodextrin (β-CD) was examined in this study. Avicel PH 101 and 301 were included for comparison. The codried product, Avicel PH 101 and 301 were granulated with water, and the granules were milled to retain three different size fractions: 37-60 μm, 60-150 μm, and 150-420 μm. The original Avicels and codried product were lubricated with magnesium stearate in three different percentages (0.2, 0.5, and 1.0%). The results showed that the powder flowability and disintegration of codried product and Avicels were significantly improved after wet granulation. However, the compactibility of ...
Pulmonary drug delivery is currently the focus of accelerated research and development because of the potential to produce maximum therapeutic benefit to patients by directly targeting drug to the site of pathology in the lungs. Among the available delivery options, the dry powder inhaler (DPI) is the preferred device for the treatment of an increasingly diverse range of diseases. However, because drug delivery from a DPI involves a complex interaction between the device and the patient, the engineering development of this medical technology is proving to be a great challenge. Development of DPI systems that target the delivery of fine drug particles to the deeper airways in the lungs using a combination of improved drug formulations and enhanced delivery device technologies means that each of these factors contributes to overall performance of the aerosol system. There are a large range of devices that are currently available, or under development, for clinical use, however no individual device ...
Micron and sub-micron spherical silver powders are widely used in solar battery positive silver paste for its good electrical conductivity.Chemical reduction method is currently one of the main preparation methods to prepare spherical silver powders,but the silver powders are usually of poor dispersion and broad particle size distribution.In order to prepare silver powder with narrow particle size distribution,good sphericity and fine silver powder dispersion,the experiment was carried out based on the chemical reduction method.Polyethylene glycol(PEG-6000) and emulsion dispersion were selected as two different dispersing systems,and the silver powder particle size distribution and the spherical degree were compared by adjusting the experimental conditions.With polyethylene glycol(PEG) as dispersant to prepare silver powder,the main factors of dispersant content,reaction temperature and pH value were changed; with emulsion as dispersant to prepare silver powder,the main factors of surfactant content
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The steel powder compacts exhibited an unusual combination of strength and ductility in every state of heat-treatment which was employed, The numerical values of the tensile properties were lower than those obtained from wought material of similar composition but considerably higher than anay which have previously been obtained for powder compacts. The hardness of the heat-treated powder compacts tempered after quenching was lower than that of the corresponding wrought bars. The resistance of the powder compacts to impact (as measured by tests on snall un-notched bars) was lower than that of wrought bars of corresponding size but higher than that which would normally be expected of powder material of such high strength characteristics. The elastic modulus of thesteel powder compacts was approximately the same (30,000,000 p.s.i.) as that of wrought steel bars, This is regarded as being unusual for powder metal material.DUCTILITY
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