The POU domain gene family of transcription factors share a conserved bipartite DNA binding domain, and exhibit distinct temporal and spatial patterns of expression during development, particularly in the forebrain. A cDNA encoding a new member of the POU-III class of the POU domain gene family, ref …
POU domain genes have been shown to be important in tissue-specific gene regulation during development. We have cloned cDNAs encoding two unique Xenopus laevis POU-domain proteins, XLPOU 1 and XLPOU 2. Sequencing revealed that the POU domain of both of these genes have greater than 90% homology with that of the POU III class of proteins. XLPOU 1 gene expression begins at the neural plate stage, while XLPOU 2 gene expression is first detected at the neurula stage; both XLPOU 1 and XLPOU 2 transcripts continue to be expressed throughout development. In adults, XLPOU 1 expression is restricted to the skin and brain, while XLPOU 2 is observed in the kidney and brain. In dissected embryos, both XLPOU 1 and XLPOU 2 are expressed in the dorsoanterior portion of an early tailbud embryo. Consistent with this localization, uv treatment, a condition that "posteriorizes" embryos, greatly reduces the expression of XLPOU 1 and XLPOU 2. Whole-mount in situ hybridization demonstrates that at the neural fold ...
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p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
DNA-binding regulatory protein implicated in early development. Involved in neuronal cell fate decision. May act as an octamer-dependent activator of transcription (By similarity).
Innate immune reactions protect organisms against a variety of infections. In metazoans, these reactions involve both cellular and humoral responses. The immune responses have to be well-tuned, as excessive immune activation is associated with tissue-specific pathologies. However, the transcriptional regulatory mechanisms underlying how immune responses are balanced are still not well understood. The aim of this study was to investigate the role of the Drosophila POU/Oct transcription factor Nubbin (Nub) in regulating Drosophila innate immunity, with a special focus on intestinal immune and epithelium homeostasis.. In Paper I, we show that the nub gene encodes two independent transcription factor isoforms, Nub-PB and Nub-PD. The short isoform, Nub-PD, acts as a repressor of NF-κB/Relish-dependent antimicrobial peptide (AMP) gene expression in healthy flies. Furthermore, we demonstrate that Nub-PD directly binds to Oct sequence motifs located in the distal promoter region of several AMP genes, ...
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We amplified the preferred binding site from the pool of random oligonucleotides by six selection cycles and determined its sequence as 5′-AT(G/A)CGGGT-3′. To verify the ability of GST-GCM to bind to this sequence, we used oligonucleotides with the determined sequence in their center. Indeed, both 5′-ATACGGGT-3′ and 5′-ATGCGGGT-3′ were bound by GST-GCM (Fig. 3A). However, binding of GST-GCM to 5′-ATACGGGT-3′ was consistently weaker than binding to 5′-ATGCGGGT-3′. This might indicate, that a G at the third position is preferred over an A. The GCM-binding site is related to the octamer motif (5′-ATGCAAAT-3′) that is recognized by all members of the POU family of transcription factors (21-23). Compared with the octamer motif, three consecutive Gs are present in the GCM-binding site instead of three As. Despite this similarity, GCM did not recognize the octamer motif just as POU domain proteins did not recognize the GCM-binding site (data not shown). Binding to the ...
Pou2af1 - Pou2af1 (untagged) - Mouse POU domain, class 2, associating factor 1 (Pou2af1), (10ug) available for purchase from OriGene - Your Gene Company.
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Transcription factor that binds preferentially to the octamer motif (5-ATGTTAAT-3). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity ...
1CQT: Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface.
rat Pou2f3 protein: member of the POU domain family of transcriptional regulators; highly related to Oct-2; expressed in terminally differentiating epidermis; RefSeq XM_343378
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Complete information for POU2F2 gene (Protein Coding), POU Class 2 Homeobox 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for POU6F1 gene (Protein Coding), POU Class 6 Homeobox 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Gene target information for POU4F1 - POU class 4 homeobox 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
POU4F2 - POU4F2 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector shRNA available for purchase from OriGene - Your Gene Company.
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Upozorňujeme, že ochranná známka BIOQUANT TM ako slovná ochranná známka ale aj jej grafická podoba patria firme Yalong Trade s.r.o. a akékoľvek jej používanie bez licencnej zmluvy s firmou Yalong Trade s.r.o. bude v rozpore s priemyselno právnou ochranou. Ochrana našich práv bude riešená prostredníctvom našich právnych zástupcov. Partneri spoločnosti Yalong Trade s.r.o. a Kingray s.r.o. sú povinní použitie slovka BIOquant spojiť so symbolom R v krúžku alebo označením TM. ...
Pokud nenaleznete technický dotazník pro Vámi požadovaný druh, použijte TD ze stránek CPVO nebo tento technický dotazník. If you dont find the TQ for your requiered species, use the TQ from the CPVO website or this General Technical Questionaire.. ...
SÚKL zajišťuje, aby v ČR byla dostupná pouze kvalitní, účinná a bezpečná humánní léčiva, a aby byly používány pouze bezpečné a funkční zdravotnické prostředky.
SÚKL zajišťuje, aby v ČR byla dostupná pouze kvalitní, účinná a bezpečná humánní léčiva, a aby byly používány pouze bezpečné a funkční zdravotnické prostředky.
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TY - JOUR. T1 - Characterization of an acetylcholine receptor α3 gene promoter and its activation by the POU domain factor SCIP/Tst-1. AU - Yang, Xiangdong. AU - McDonough, Jennifer. AU - Fyodorov, Dmitry. AU - Morris, Mark. AU - Wang, Feng. AU - Deneris, Evan S.. PY - 1994/4/8. Y1 - 1994/4/8. N2 - Genes encoding neuronal nicotinic acetylcholine receptors exhibit restricted patterns of expression in the nervous system. We are interested in elucidating the molecular mechanisms responsible for establishing these patterns of expression. This paper presents the characterization of regulatory elements upstream of the neuronal nicotinic acetylcholine receptor α3 gene. We have identified a GC-rich multistart site promoter adjacent to the α3 coding region. Similar α3 start sites were identified in PC12 cells and sympathetic ganglion neurons, suggesting similar control mechanisms in the clonal line and peripheral neurons. The start site region lacks TATA- like sequences but does contain ...
The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.. ...
Looking for online definition of POU domain, class 2, associating factor 1 in the Medical Dictionary? POU domain, class 2, associating factor 1 explanation free. What is POU domain, class 2, associating factor 1? Meaning of POU domain, class 2, associating factor 1 medical term. What does POU domain, class 2, associating factor 1 mean?
Mouse Hox 1.11 homeobox DNA was cloned and sequenced. Hox 1.11 poly A+ RNA is expressed in 12 to 14 day-old mouse embryos in the hind brain up to, but not including, the pons. Hox 1.11 poly A+ RNA also was expressed in the spinal cord, the VIIth and VIIIth cranial ganglia, spinal ganglia, larynx, lungs, vertebrae, sternum, and intestine. A mouse homeobox gene, mNK-1, was cloned and approximately 5.2 kb of DNA was sequenced. Comparison of the amino acid sequences of the mouse and Drosophila NK-1 revealed 95% homology. Hox 4.1 cDNA and genomic DNA were cloned and sequenced; comparison of Hox 4.1 and Hox 2.7 proteins revealed 59% homology. Hox 4.9 also was cloned and partially sequenced. Four Pou-domain genes expressed in embryonic and adult mouse brain were cloned and sequenced: Brain-1, Brain-2, Brain-4, and Scip. Similar amino acid sequences were found in various regions of the proteins. No introns were detected in the coding regions of the 4 Pou-domain genes which suggests that the genes ...
The Drifter, one of a few traveling food trucks that have taken to El Paso streets in the past year, is in the process of finding a place to call home. Since last July, devoted followers, hungry lunch seekers and those curious to try something new have kept up with The Drifters daily locations on Facebook and Twitter.. But drifting has turned out to be bad for business, said owner Ian Atkins.. "We found that people dont want to look for us," Atkins said. "The more we are in one place, it increases sales dramatically. It also helps the food be more fresh and gourmet if you dont have to transport it around so much.". Atkins and former partner Reed Hanson started The Drifter as a business venture last July in the hopes of kicking off a trend in El Paso where food trucks are common. Hanson has since returned to his previous day job.. Atkins referred to Austin as an example of a city where the food truck industry is booming.. "A bar in Austin can set up a food trailer in front that remains there," ...
Introduction: The Dlx1/Dlx2 double knockout mouse has reduced numbers (33% fewer) of retinal ganglion cells (RGC), due to enhanced apoptosis. Brn3a and Brn3b are closely related members of the Class IV POU-domain gene family, and play functionally interchangeable roles in retinal development. We hypothesized that Brn3a and/or Brn3b are direct DLX transcriptional targets during retinal development. Methods: Chromatin immunoprecipitation (ChIP) assays were performed on E16.5 retinas to identify DLX proteins bound to the Brn3a or Brn3b promoters. Electrophoretic mobility shift assays (EMSA) were used to confirm the specificity of this binding. Luciferase reporter gene assays were performed to confirm the functional significance of DLX binding to the Brn3 or Brn3ba promoters in vitro. In utero retinal electroporation was used to study the effect of DLX gain-of-function on Brn3a/Brn3b expression in vivo. Compound Dlx1/Dlx2/Brn3a and Dlx1/Dlx2/Brn3b knockout mice were generated for analysis of retinal ...
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The asymptotic relationship observed between drifter abundance and observed larval abundance could be related to lower survival of ELS very close to the coast, which is where the highest concentrations of drifters occurred. Stranding of eggs onto the coast, higher predation during the drifting process and higher mortality at high larval densities (e.g. because of food limitation) are all factors that may have contributed to low survival. However, it is worth noting that the unresolved currents in the coastal areas owing to the confluence of multiple drivers interacting at fine to meso scales near shore could potentially overestimate drifters along the coast [6]. Although a padding zone was included in the particle-tracking model to mitigate this problem, overestimation of drifter density along the coast is certainly possible. Nevertheless, the spatial pattern of our results is consistent with other studies applying different ocean models [2,20].. Having accounted for drifter abundance (i.e. the ...
The mammalian retina and inner ear are two of the most common places of genetic diseases that cause blindness and deafness due to the degeneration of retinal and inner ear neurons. In order to understand the disease processes, it is very crucial to elucidate the fundamental mechanisms regulating the normal development and maintenance of these neurons at the molecular level. My research is centered on identifying genes required for neuron differentiation and survival, investigating the genetic pathways involved in these processes, and developing therapies for blindness and deafness via gene therapy and stem cell replacement. I am currently investigating the roles of three classes of transcription factors (TFs), the basic helix-loop-helix (bHLH), POU-homeodomain (POU-HD), and LIM-domain TFs, in the formation and maintenance of mouse retina and inner ear. Using homologous recombination in mouse embryonic stem (ES) cells to mutate these TF genes, I have shown that these TFs function in a cascade to ...
But if I was to post something like "Back home when I was growin up, our babies teethed on guns. Ya see, a nice woman, married with a baby, one afternoon saw a drifter approaching her house. She knew he would bother her something fierce for food and take advantage of her. So she took out her husbands gun, only she found that it werent loaded. Jest then, that drifter walked right in the door without knocking or nothing. So the woman dropped the empty gun into the crib and tried to fend him off. That drifter was all set to take every bite of food the little lady had prepared for her husbands dinner, and give her a hard time to boot. But he happened to glance into the crib, and saw the womans little feller jest gumming away at the handle of that ol .45. Well that drifter turned pale and high-tailed it out of there, cause he didnt cotton to stayin in a place where the babies teeth on guns." Now that sorta thing obviously is full of truth and such, but simply by associating with MOAB ...
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POU5F1 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of POU5F1 expression in cultured cells. (KA2545) - Products - Abnova