postmortem changes and time of death a professional pdf from dundee university concerning changes in the human body after death and thereby ascertaining the time of death ref dundee university

Decomposition of an exposed cadaver is a continuous process, beginning at the moment of death and ending when the body is reduced to a dried skeleton. Trad

Background: Although essential tremor (ET) is one of the most common neurologic disorders, there have been few postmortem studies. We recently reported postmortem changes (torpedoes and Bergmann gliosis) in the cerebellar cortex in a few ET cases. Objective: To describe more extensive postmortem changes in the cerebellum in another ET case. Design: Case report. Results: A 90-year-old woman had a 30-year history of ET. At postmortem examination, there was segmental loss of Purkinje cells, presence of torpedoes, and Bergmann gliosis in the cerebellar cortex. Moreover, there were extensive changes in the dentate nucleus, in the form of neuronal loss, neuronal atrophy, microglial clusters, and reduction in the number of efferent fibers (ie, pallor of the hilum). Conclusions: The brain in the current case exhibited more marked cerebellar pathologic features than noted in previously reported ET cases and thereby extends the described cerebellar findings in this common, yet pathologically poorly characterized,

Objectives We prepared a map of the cleavage lines for beagle dogs, as a guideline for use of cleavage lines in dermatoplasty. Results The cleavage lines at the head resembled the orientation of the underlying muscles. Although the cleavage lines in the trunk were perpendicular to body axis, those in the thoracoabdominal region were parallel to the body axis. The cleavage line at the limbs were parallel to the lomg axis of the limb on the cranial surface, but were perpendicular to the long axis of the limb on the lateral and caudal surfaces. Also, we recorded in detail the cleavage lines in the distal regions of the limbs. Conclusion These findings suggest that, when assessing skin cleavage line, it is necessary to consider cleavage line detection methods, size of punched holes, and post-mortem changes. In the present study, post-mortem changes were minimized, and the density of holes was high. Although more studies are needed to investigate differences between species and individuals, the ...

In performing postmortem CT angiography (PMCTA), we expect to encounter artefacts. In addition to those that have been well characterized in radiologic imaging, such as physics-based artefacts (e.g., beam hardening, partial volume, photon starvation), patient-based artefacts (e.g., metallic materials and patient motion), or scanner-based artefacts (e.g., ring artefacts, incomplete projections, cone beam effect), we can also expect specific artefacts arising from postmortem changes and the artificial perfusion of the body. The artefacts observed in PMCTA obviously depend on the method applied. To date, they have been described in detail only for the technique of multiphase PMCTA. Concerning this method, the observed artefacts are reproducible and stable in their localization, making them easily detectable. Understanding them is important, however, in order to avoid misinterpretation. This chapter gives an overview of these artefacts, which can be divided into three categories: (1) artef

Reactive oxygen species (ROS) are generated in all aerobic organisms. Free radicals are highly reactive ROS that cause damage to biological materials. Fish is rich in polyunsaturated fatty acids, and hence, very prone to lipid peroxidation. Both lipid and protein oxidations are important for quality loss during storage of fish, with high impact on taste and texture. Also, there are interactions between protein and secondary lipid oxidation products (aldehydes) that occur in foods because the oxidation products from one reaction can further react with both lipids and proteins respectively. This review focuses on the mechanisms and pathways of the lipid and protein oxidation and their possible relationship. Additionally, the target amino acids and final impacts of this relationship were considered. We propose that the products of lipid oxidation promote protein oxidation in fish rather than the other way around specially, during frozen storage, while during postmortem changes protein oxidation ...

Composition of the meat, post-mortem changes in skeletal muscles, meat traits, meat og game and exotic animals. The properties and composition of the meat products. The composition of milk and dairy products. Structure, composition of fish and fish products. Structure, composition and properties of eggs and egg products. The composition and properties of honey. The nutrient value of foods ...

Background: In forensic science the identification of a human is based on three important factors: Age, Sex and Stature. Bones are an important tool for it and among human bones the pelvis and the skull are the most reliable source for sex determination. In the absence of complete pelvis, mandi-ble becomes the important source for sex determination since mandible is the most durable and movable part of skull that can resist postmortem changes. The present study is conducted to assess the accuracy and role of few metric and morphological parameters in determination of the sex of dry adult human mandible of North Indian origin. Material & Methods: The Study is conducted on 50 dry intact human adult mandibles of North Indian origin. The metric parameters i.e. bigonial breadth, bicondylar breadth are measured with a Vernier Calliper by two observers. Non-metric parameters being observed are the morphological features like gonion flaring, muscular markings and shape of angle of symphysis menti. Result &

Agrawal, T. N. (1975) Pressure of Population on Rural Land Use in Bareilly District. PhD thesis, Aligarh Muslim University. Agre, Jagat Vir Singh (1975) The Mughal Impact on the Culture of Rajasthan (From the Middle of the 16th. to the End of the 17th. Century). PhD thesis, Aligarh Muslim University. Ahmad, Aqil (1975) Studies on the Effect of Pyridoxine on the Growth and Yield of Barley. PhD thesis, Aligarh Muslim University. Ahmad, Iftikhar (1975) Kinetics and Mechanism of the Epoxidation of α , β - Unsaturated Aldehydes and Acids. PhD thesis, Aligarh Muslim University. Ahmad, Ishraq (1975) Some Aspects of Post-Mortem Changes in Freshwater Fish. Masters thesis, Aligarh Muslim University. Ahmad, Mansoor (1975) Entire Functions and Cauchys Theorem. PhD thesis, Aligarh Muslim University. Ahmad, Riyaz (1975) Socio-Economic Survey of Cottage Industries in Aligarh. Masters thesis, Aligarh Muslim University. Ahmad, Syed Waseem (1975) Distribution of Nutritional Deficiency Diseases in Relation to ...

An outbreak of MCF occurred in June - August 2017 in Kharchev village in Irkutsk Oblast, Russia. In this paper, we provide epidemiological (sanitary status of pastures, watering places, and premises) and weather data during the outbreak, and descriptions of the clinical signs and post-mortem changes in cattle. The virus was detected and isolated from pathological material samples and identified by molecular methods. ...

Background The post-mortem interval (PMI) is the time elapsed since the dead of an individual until the body is found, which is relevant for forensic purposes. The miRNAs regulate the expression of some genes; and due to their small size, they can better support degradation, which makes them suitable for forensic analysis. In the present work, we evaluated the gene expression of miR-381-3p, miR-23b-3p, and miR-144-3p in skeletal muscle in a murine model at the early PMI. Methods We designed a rat model to evaluate the early PMI under controlled conditions. This model consisted in 25 rats divided into five groups of rats, that correspond to the 0, 3, 6, 12 and 24 hours of PMI. The 0 h-PMI was considered as the control group. Muscle samples were taken from each rat to analyze the expression of miR-381-3p, miR-23b-3p, and miR-144-3p by quantitative RT-PCR. The gene expression of each miRNA was expressed as Fold Change (FC) and compared among groups. To find the targets of these miRNAs and the pathways

Many potentially valuable techniques for the understanding of human neurobiological and neuropathological processes require the use of RNA obtained from postmortem tissue. As with earlier neurochemical studies, there are two particular problems posed by such tissue in comparison with tissue from experimental animals. These are the postmortem interval and the condition of the patient prior to death, referred to as the agonal state. We review the nature and extent of the effects of postmortem interval and agonal state on RNA in brain tissue, with particular reference to the study of neuropsychiatric disorders. Perhaps surprisingly, postmortem interval has at most a modest effect on RNA. Abundant intact and biologically active RNA is present in tissue frozen 36 h or more after death. Postmortem interval does not account for the marked variability observed among human brains in all RNA parameters. Despite the overall stability of RNA after death, some evidence suggests that individual RNAs may undergo

Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be studied, it is critical to understand the post-mortem stability of the modifications. Pig and mouse brain tissue were formalin-fixed and paraffin-embedded, or frozen after post-mortem delays of 0, 24, 48, and 72 h. Epigenetic modifications frequently reported in the literature were studied by DNA agarose gel electrophoresis, DNA methylation enzyme-linked immunosorbent assays, Western blotting, and immunohistochemistry. We constructed a tissue microarray of human neocortex samples with devitalization or death to fixation times ranging from | 60 min to 5 days. In pig and mouse brain tissue, we found that DNA cytosine modifications (5mC, 5hmC, 5fC, and 5caC) were stable for ≥ 72 h post-mortem. Histone methylation was generally stable for ≥ 48 h (H3K9me2/K9me3, H3K27me2, H3K36me3) or ≥ 72 h post-mortem (H3K4me3, H3K27me3). Histone acetylation was

Down syndrome (DS) occurs with triplication of human chromosome 21 and is associated with deviations in cortical development evidenced by simplified gyral appearance and reduced cortical surface area. Radial glia are neuronal and glial progenitors that also create a scaffolding structure essential for migrating neurons to reach cortical targets and therefore play a critical role in cortical development. The aim of this study was to characterise radial glial expression pattern and morphology in the frontal lobe of the developing human fetal brain with DS and age-matched controls. Secondly, we investigated whether microstructural information from in vivo magnetic resonance imaging (MRI) could reflect histological findings from human brain tissue samples. Immunohistochemistry was performed on paraffin-embedded human post-mortem brain tissue from nine fetuses and neonates with DS (15-39 gestational weeks (GW)) and nine euploid age-matched brains (18-39 GW). Radial glia markers CRYAB, HOPX, SOX2, GFAP and

Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations.

This report is intriguing and reinforces the power of single-nucleus studies of human postmortem brain tissue for understanding neurodegenerative disease. The identification of RORB as a possibly critical protein associated with selective vulnerability may lead to new mechanistic insights into neurofibrillary tangle formation, if confirmed in other single-nucleus studies and hopefully as well by studies using other approaches to single-cell or defined-cell-type analysis.. The authors used CP13, marker of early to middle stages of neurofibrillary tangle development (Vingtdeux et al., 2011). Comparison with a late-stage tangle marker such as PHF-1 might be of assistance in sorting out the stage at which RORB becomes involved.. One of the major deficiencies of single-nucleus studies, however, is that there is the assumption that the nuclear transcriptome will be a useful reflection of the cytoplasmic transcriptome. The nuclear transcriptome differs in that it contains many pre-mRNAs that are not ...

Authors: Lester-Coll, Nataniel , Rivera, Enrique J. , Soscia, Stephanie J. , Doiron, Kathryn , Wands, Jack R. , de la Monte, Suzanne M. Article Type: Research Article Abstract: The cascade of Alzheimers disease (AD) neurodegeneration is associated with persistent oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of pro-death signaling pathways. More recently, studies with human postmortem brain tissue linked many of the characteristic molecular and pathological features of AD to reduced expression of the insulin and insulin-like growth factor (IGF) genes and their corresponding receptors. We now demonstrate using an in vivo model of intracerebral Streptozotocin (ic-STZ), that chemical depletion of insulin and IGF signaling mechanisms combined with oxidative injury is sufficient to cause AD-type neurodegeneration. The ic-STZ-injected rats did not have elevated blood glucose levels, …and pancreatic architecture and insulin immunoreactivity were similar to ...

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Background. Previous studies evidenced as median nerve fibers underwent a marked demyelinization process, related to the time-since-death and associated to an evident increase in tissue cholesterol levels. Aims. The present research was aimed to correlate the increment in tissue cholesterol concentration (CHOL) with the post-mortem interval (PMI). Methods. Male and female Caucasian subjects (25-53 years old) without diagnosed neurological or metabolic diseases were chosen for the study. Two samples of median nerves were collected from the right and left wrist at intervals ranging from 30 minutes to two hours (t1 and t2). Fragments of approximately 1 cm were collected and analyzed by gas chromatographic/mass spectrometry (GC/MS), after chemical digestion in basic environment. CHOL quantification in median nerve was performed by means of a calibration curve in the range (9.25-150) ng/µL. The method was validated according to FDA guidelines. Data have been corrected with respect to the amount of ...

Schoenly, K.; Griest, K.; Rhine, S., 1991: An experimental field protocol for investigating the postmortem interval using multidisciplinary indicators

Our objectives were to examine the effects of prerigor excision and rapid chilling vs. conventional carcass chilling of two muscles on proteolysis and tenderness during the postmortem storage, as well as the effects of fast and slow rates of cooking on myofibrillar characteristics and tenderness. The longissimus thoracis (LT) and triceps brachii (TB), long head muscles were removed 45 min after exsanguination from the left side of 12 carcasses and chilled in an ice bath to induce cold shortening (excised, rapidly chilled). At 24 h postmortem, the corresponding muscles were removed from the right side (conventionally chilled). All muscles were cut into 2.54-cm-thick steaks and assigned to one of two postmortem times (1 or 14 d), and to raw and cooking treatments. Steaks were cooked at 260°C(FAST) or 93°C(SLOW) in a forced-air convection oven to an internal temperature of 70°C. Cooking loss, cooking time, and Warner-Bratzler shear force (WBSF) were measured on cooked steaks. Sarcomere length ...

Background: The polyamines are a group of ubiquitous low molecular weight aliphatic molecules that play an essential role in various physiological functions of the mammalian CNS. Previous literature has indicated alterations in the expression of polyamine-related genes in the brains of individuals who died by suicide; including downregulation of spermidine/spermine N1-acetyltransferase (SAT1), a key enzyme involved in polyamine catabolism. One such polyamine, namely agmatine, has been shown to act as an anti-depressant in animal models of depressive-like behaviour. Yet, agmatine concentrations have not been explored in postmortem human brain of suicides.Methods: In order to measure agmatine in post-mortem human brain tissue, we employed our previously published high-resolution capillary gas chromatography (GC) in combination with mass spectrometry (MS) method. Using this method, we analyzed agmatine levels in a total of 120 tissue samples from Brodmann areas 4, 11, and 44 of 40 male subjects ...

Health, ... While the majority of Alzheimers researchers focus their att...Manhasset NY (Vocus) May 24 2010 -- While the majority of Alzheimer&...,Molecular,Signatures,in,Post-Mortem,Brain,Tissue,of,Younger,Individuals,at,High,Risk,for,Alzheimer's,Disease,,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

BRAINCODE: How Does the Human Genome Function in Specific Brain Neurons? The human brain comprises about 86 billion neurons whose function is central to human biology. How does the human genome program high performing neurons and neural networks in response to experience? What subprograms does the genome express in physiologically and morphologically distinct brain cells? The goal of the BRAIN Cell encyclOpeDia of transcribed Elements Consortium (BRAINcode) is to provide a map of gene expression - both protein-coding and non-coding - in specific cell types, not in culture, but in situ in brains of people. Going beyond traditional mRNA sequencing, polyadenylated and non-polyadenylated transcripts were ultra deeply sequenced using ribo-depleted RNA from neurons laser-captured from human post-mortem brains. Three prototypical neuron types, dopamine neurons, pyramidal neurons, and Betz cells, were prioritized because of their key biologic roles and differential vulnerability to important ...

The JuBrain CytoViewer shows cytoarchitectonic probabilistic maps, which have been developed in the teams of Katrin Amunts and Karl Zilles in Juelich and Duesseldorf (INM-1). Cytoarchitectonic areas were analyzed in histological sections of ten human postmortem brains. The maps are based on image analysis and statistical criteria for localizing areal borders. Cytoarchitectonic maps have been developed during the past 20 years as a joint effort of many doctoral students, post docs and guest scientists. Maps, which have been published, are available for the scientific community. When you use the maps, please cite their authors (see below) for good scientific practice. Maps should not be used commercially. The JuBrain Cytoarchitectonic Atlas Viewer is based on the WebGL framework which is not supported for all available web browsers. Please consult https://www.jubrain.fz-juelich.de/information.php for technical preconditions.. ...

Parkinsons Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinsons disease.

First author Adamantios Mamais tells us about his recent publication in Neurobiology of Disease: At the Queen Square Brain Bank (part of the UCL Institute of Neurology) we hold a large collection of post-mortem human brain tissue from patients with neurodegenerative diseases including Parkinsons disease (PD); a debilitating neurological disorder that affects the central nervous…

Postmortem human brain tissue is essential for studies of the pathobiology and causes of Parkinsons disease (PD). The chief goal of the Clinical &Neuropatholog...

28.RansohoffR,PerryV: Microglialphysiology:uniquestimuli,stimuli, specializedresponses. AnnuRevImmunol 2009, 27: 119 145. 29.BabaH,NakahiraK,MoritaN,TanakaF,AkitaH,IkenakaK: GFAPgene expressionduringdevelopmentofastrocyte. DevNeurosci 1997, 19 (1):49 57. 30.Lpinoux-ChambaudC,EyerJ: Reviewonintermediatefilamentsofthe nervoussystemandtheirpathologicalalterations. HistochemCellBiol 2013, 140 (1):13 22. 31.CondeF,LundJS,JacobowitzDM,BaimbridgeKG,LewisDA: Localcircuit neuronsimmunoreactiveforcalretinin,calbindinD-28korparvalbumin inmonkeyprefrontalcortex:distributionandmorphology. JCompNeurol 1994, 341 (1):95 116. 32.ImaiY,IbataI,ItoD,OhsawaK,KohsakaS: AnovelgeneIba1inthemajor histocompatibilitycomplexclassIIIregionencodinganEFhandprotein expressedinamonocyticlineage. BiochemBiophysResCommun 1996, 224: 855 862. 33.CasanovaMF: Theneuropathologyofautism. BrainPathol 2007, 17 (4):422 433. 34.SmithAM,GibbonsHM,OldfieldRL,BerginPM,MeeEW,CurtisMA,Faull RL,DragunowM: ...

One thing that wasnt discussed in Dr. Harts piece, but I did see discussed in another article (with quotes from forensic toxicologists Dr. Bruce Goldberger and Dr. Nikolas Lemos) was postmortem redistribution (PMR).PMR is a phenomenon that occurs after death when drugs stored in tissues and organs diffuse back into the blood stream. This diffusion can falsely elevate the blood level at autopsy and may not be representative of the drug concentration at the actual time of death. THC can undergo PMR. In a series of 19 deaths, heart:femoral blood concentration ratios average 1.5 (range, 0.3-3.1) for THC. (Holland et al., 2010). In this case, femoral blood was analyzed, so PMR should be minimized, but it still can occur. If resuscitation was attempted (and I do not know if it was), then this could have also played a role in movement of blood from central to peripheral sites or even release of drug from tissues into blood creating a false elevation in blood drug concentration. Did PMR occur in this ...

This is the first longitudinal study to show hyperattenuation of striated muscle on postmortem CT images compared with antemortem CT images in the same patients.

Between 1997 and 1999 a steady increase in cornea donations was achieved, but the number of transplantations remained stable because many grafts did not pass quality control. Intermediate organ culture of entire bulbi was examined as a possible solution to reduce post-mortem times and increase suitability for transplantation.

Looking for Postmortem lividity? Find out information about Postmortem lividity. The reddish-blue discoloration of the cadaver that occurs in the dependent portions of the body due to gradual gravitational flow of unclotted blood Explanation of Postmortem lividity

The foremost expert in the world on post mortem chemistries is John I. Coe, M.D. He has been recognized as a universally acknowledged expert on the bodys chemistry following death. In re Matter of Sybers, 583 N.W.2d 890 (Iowa S.Ct., 1998) (Exhibit 38). His C.V. lists 42 articles and 8 textbooks. (Coe Deposition, p418 - Exhibit 36.) A full professor of pathology and medical examiner for 30 years, Dr. Coe has no equal. (See attached C.V. and his latest deposition excerpt beginning at page 414.) More importantly, he has been sited as a reference in over 130 publications. Even Scientology s expert, Dr. Wecht, has published annual reports which included a review article on postmortem chemistries by Dr. Coe, who Dr. Wecht recognized as the pioneer in post mortem chemistry. There has never been a peer reviewed article that challenges the validity of Dr. Coe s work on vitreous being the best reflector of antemortem serum values. (Coe Deposition, p421 - Exhibit 36.) Over the years he has put on 4 hour ...

The microglia are central to aging in the brain and science is already finding ways to reverse it like introducing young microglia to the brain to remove plaques associated with Alzheimers. Brain aging is not a one way process! The difference between an old brain and a young brain isnt so much the number of neurons but the presence and function of supporting cells called glia. In Cell Reports on January 10, researchers who examined postmortem brain samples from 480 individuals ranging in age from 16 to 106 found that the state of someones glia is so consistent through the years that it can be used to predict someones age. The work lays the foundation to better understand glias role in late-in-life brain disease.

Rubies Real F/X Postmortem Prosthetic has been painstakingly designed to replicate a real-life postmortem wound. Great for use in horrific special FX makeup creations or as part of a killer, morgue, undead or zombie Halloween costume, the postmortem wound

Calmodulin-like skin protein is downregulated in human cerebrospinal fluids of Alzheimer fs disease patients with apolipoprotein E4; a pilot study using postmortem samples. Neurological Research. 2017 Sep;39(9):767-772. doi: 10.1080/01616412.2017.1335458. Epub 2017 Jun 7 ...

Canberra, Oct 21 (IANS): Researchers have found that fatty tissues accumulate in the airway walls, particularly in people who are overweight or obese.. The study, published in the European Respiratory Journal, suggested that the fatty tissue alters the structure of peoples airways and this could be one reason behind the increased risk of asthma.. Our research team studies the structure of the airways within our lungs and how these are altered in people with respiratory disease, said the studys author John Elliot from Sir Charles Gairdner Hospital in Australia.. Looking at the samples of lungs, we spotted fatty tissue that had built up in the airway walls. We wanted to see if this accumulation was correlated with body weight, Elliot said.. The researchers examined post-mortem samples of the lungs that had been donated for the research and stored in the Airway Tissue Biobank.. They studied samples from 52 people, including 15 who had no asthma, 21 who had the disease but died of other causes ...

Health,The brains of patients with mild cognitive impairment display patholog...Mild cognitive impairment--difficulty with thinking learning and memo...In the first study Ronald C. Petersen Ph.D. M.D. Mayo Clinic Colle...Most of the patients did not meet the requirements for a post-death di...,Post-mortem,brain,studies,reveal,features,of,mild,cognitive,impairment,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news

UP10679 Discovered on November 9, 1973 DEMOGRAPHICS Caucasian male Height: 511 Weight: Estimated at 180 lbs Postmortem interval: 9 hours

Xamination post mortem (Supplemental Fig. 1), however, in vivo and ex vivo lung assessments for bioluminescence were negative (data not shown). A formal

Read or print original Post Mortem lyrics 2020 updated! Vision is blurred yo / / This is the last chapter / Bombs hit who? Crushed

Our previous study found that more than 500 transcripts significantly increased in abundance in the zebrafish and mouse several hours to days postmortem relative to live controls. The current literature suggests that most mRNAs are post-transcriptionally regulated in stressful conditions. We rationalized that the postmortem transcripts must contain sequence features (3- to 9- mers) that are unique from those in the rest of the transcriptome and that these features putatively serve as binding sites for proteins and/or non-coding RNAs involved in post-transcriptional regulation. We identified 5117 and 2245 over-represented sequence features in the mouse and zebrafish, respectively, which represents less than 1.5% of all possible features. Some of these features were disproportionately distributed along the transcripts with high densities in the 3′ untranslated regions of the zebrafish (0.3 mers/nt) and the open reading frames of the mouse (0.6 mers/nt). Yet, the highest density (2.3 mers/nt) occurred in

Maaha Khawar BBA 2K10 B Post-Mortem Report Creative Brief 12- EcoSolutions Post-Mortem Report Creative Brief 12- EcoSolutions Client: Youth for Change Team

A Postmortem on Shadow of the Sun... Note: This postmortem is not technical. It is about the human dynamics as I experienced them.

Clear documentation is key to an effective incident postmortem. Use this postmortem template to capture all of the important details about an incident.

Clear documentation is key to an effective incident postmortem. Use this postmortem template to capture all of the important details about an incident.

It should be noted that agonal breathing is not a cause of death in and of itself.. The underlying cause is usually something like cardiac arrest or ischemic stroke, and the patients chances of survival depend on a number of factors-such as their existing state of health and any underlying medical conditions, their age, and how quickly they get help.. Cardiac arrest usually occurs outside of a hospital-more than 88% of the 395,000 cases that occur each year happen in someones home. The survival rate (depending on which statistics youre looking at) may be as low as 6% or even less. But it tends to go up significantly if the victim is lucky enough to receive CPR from a bystander very quickly after collapse.. Ischemic stroke is a bit more survivable in the short term-some studies have shown a 60% survival rate after one year-but the number goes down to 31% after five years.. Survival rates for stroke also depend on a variety of factors, such as the age of the victim, whether this was their first ...

We held the post-mortem for the summers projects yesterday. It went well---the summer, I mean, not just the post-mortem. Here are the main points ...

Nursing Education, Nutrition and Exercise, Omens, Ontological Confrontation, Operatic Death, Organ Donation and Transplantation, Organized Crime, Orpheus, Osiris, Pain and Pain Management, etc…

Looking for online definition of postmortem interval in the Medical Dictionary? postmortem interval explanation free. What is postmortem interval? Meaning of postmortem interval medical term. What does postmortem interval mean?

I. PAST AND CURRENT TEACHING RESPONSIBILITIES: Lecturer in physiology, St. Louis University School of Allied Health, 1990 Lecturer in pathology, University of Oklahoma Health Sciences Center School of Medical Technology, 1994-1995 Lecturer, pathology residency training, St. Louis University School of Medicine, 1998-present Craniocerebral Trauma , Blunt Head Injuries , Accidental Deaths in Children, Thermal Injuries, Gunshot Injuries, Postmortem Changes, Forensic Toxicology, Sudden Unexpected Death, Forensic Pathology Review 2007, Bloody Bodies and Bloody Scenes Lecturer, Medicolegal Death Investigators Course, St. Louis University School of Medicine, 2000-present Lecturer, forensic pathology elective for first year students, St. Louis University School of Medicine, 2000-present Forensic DNA Analysis, The Practice of Forensic Pathology, Forensic Case Review Lecturer, Core Graduate Physiology Course, St. Louis University School of Medicine, 2001-2006 Hormonal Regulation ...

Postmortem results presented here dovetail well with results in a cellular model revealing that increased tubulin acetylation causes the antidepressant signature response of Gαs translocation from lipid rafts (Singh et al., 2018) Current findings in postmortem brain tissue suggest that acetylation status of tubulin may be important for sequestration of Gαs in lipid rafts, as seen in depression (Donati et al., 2008). The findings lend a molecular rationale to antidepressant effects observed in HDAC6-depleted (Espallergues et al., 2012; Fukada et al., 2012; Lee et al., 2012) or pharmacological inhibitor-treated animals (Jochems et al., 2014), where increased tubulin acetylation induced behavioral effects similar to that of traditional antidepressants. While any study relying on immunodetection is subject to variability, the ability to use the comparator of acetylated to total α-tubulin lends stability to the data.. The tubulin post-translational modifications observed in postmortem brain tissue ...

Collections of human postmortem brains gathered in brain banks have underpinned many significant developments in the understanding of central nervous system (CNS) disorders and continue to support current research. Unfortunately, the worldwide decline in postmortem examinations has had an adverse effect on research tissue procurement, particularly from control cases (non-diseased brains). Recruitment to brain donor programmes partially addresses this problem and has been successful for dementing and neurodegenerative conditions. However, the collection of brains from control subjects, particularly from younger individuals, and from CNS disorders of sudden onset, remains a problem. Brain banks need to adopt additional strategies to circumvent such shortages. The establishment of brain bank networks allows data on, and access to, control cases and unusual CNS disorders to be shared, providing a larger resource for potential users. For the brain banks themselves, inclusion in a network fosters the ...

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Agonal respiration, gasping respiration or agonal breathing is an abnormal pattern of breathing and brainstem reflex characterized by gasping, labored breathing, accompanied by strange vocalizations and myoclonus. Possible causes include cerebral ischemia, extreme hypoxia (inadequate oxygen supply to tissue) or even anoxia (total depletion of oxygen). Agonal breathing is an extremely serious medical sign requiring immediate medical attention, as the condition generally progresses to complete apnea and heralds death. The duration of agonal respiration can be as brief as two breaths or last up to several hours. The term is sometimes (inaccurately) used to refer to labored, gasping breathing patterns accompanying organ failure (e.g. liver failure and renal failure), SIRS, septic shock, and metabolic acidosis (see Kussmaul breathing, or in general any labored breathing, including Biots respirations and ataxic respirations). Correct usage would restrict the term to the last breaths before ...

Chronic alcohol exposure affects the central nervous system, influences behavior, and induces neuroadaptive changes in vertebrate species including our own. literature to be alcohol related. We conclude that the zebrafish is an excellent tool for the analysis of genes associated with alcohols actions in vertebrates, one which may facilitate the discovery and better understanding of […]. ...

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Live discussion held 27 February 1998.. Participants: Peter Nelson, Nienwen Chow, Paul Coleman, Kieran Breen, Huntington Potter.. Note: Transcript has been edited for clarity and accuracy.. Nienwen Chow-Paul Coleman: We are here - Chow and Coleman.. Peter Nelson: Hi there. Im Pete Nelson. I guess most people havent arrived yet. Maybe we could wait a minute or two before intros and discussion begins.. Nienwen Chow-Paul Coleman: Fine by us. BTW Pete, we just e-mailed our responses to your comments to June K. She suggested we do it this way, so she could append them to your comments. If you wish to discuss any of the points you raised on-line here, lets do so.. Peter Nelson: Maybe in around two minutes we should start, okay?. Nienwen Chow-Paul Coleman: OK. Questions? Points? Answers?. Peter Nelson: Perhaps we should begin with some introductions. My name is Peter Nelson. Im an MD/PhD finishing my MD at U.Chicago. Im interested in AD pathobiology.. Kieran Breen: Hi, Im Kieran Breen, a lecturer ...

Title:Microendophenotypes of Psychiatric Disorders: Phenotypes of Psychiatric Disorders at the Level of Molecular Dynamics, Synapses, Neurons, and Neural Circuits. VOLUME: 15 ISSUE: 2. Author(s):S. Kida and T. Kato. Affiliation:Department of Bioscience, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, Japan.. Keywords:Animal model, bipolar disorder, depression, endophenotype, microendophenotype, psychiatric disorder, PTSD, schizophrenia.. Abstract:Psychiatric disorders are caused not only by genetic factors but also by complicated factors such as environmental ones. Moreover, environmental factors are rarely quantitated as biological and biochemical indicators, making it extremely difficult to understand the pathological conditions of psychiatric disorders as well as their underlying pathogenic mechanisms. Additionally, we have actually no other option but to perform biological studies on postmortem human brains that display features of psychiatric disorders, ...

In this study we have evaluated the postmortem pharmacokinetics of amitriptyline (Ami) and metabolites in pigs after oral and intravenous administration, and the results are compared with previous studies in rats and humans. In addition a meticulous investigation of blood and tissue concentrations after postmortem intravenous infusion of Ami was undertaken. Of a total of 9 over-night fasted pigs, 3 were given 25 mg/Kg Ami orally, and another 3 pigs received an intravenous infusion lasting 1 h of 3.3 mg/Kg Ami prior to death. The final 3 pigs were sacrificed and then given the intravenous infusion after death. After ∼5 h at room temperature, all carcasses were subsequently stored at 4-5°C. Postmortem blood samples were collected at 0.25, 1, 2, 4, 8, 24, 48, and 96 h through an indwelling intracardial needle. Postmortem examination with blood and tissue sampling was performed 96 h after death. Analysis was carried out by high performance liquid chromatography with ultraviolet detection. ...

Abstract Introduction Postmortem CT angiography is the method of choice for the postmortem imaging investigations of the cardiovascular (CV) system. However, autopsy still remains the gold standard for CV measurement. Nevertheless, there are not any studies on CV measurements on the multi-phase postmortem angiography (MPMCTA) which includes comparisons with autopsy. Therefore, the aim of this study is to compare CV measurements between the native CT scan and the three phases of the MPMCTA to find out which of these modalities correlate the best with autopsy measurements. Methods For this study, we selected retrospectively 50 postmortem cases that underwent both MPMCTA and autopsy. A comparison was carried out between the CV measurements obtained with imaging (aorta; heart cavities and cardiac wall thicknesses; maximum cardiac diameter and cardiothoracic ratio) and at the autopsy (aorta; cardiac valves, ventricular thicknesses, and weight). Results Our results show that the dynamic phase displays an

Fat loss during cooking of duck foie gras is the main problem for both manufacturers and consumers. Despite the efforts of the processing industry to control fat loss, the variability of fatty liver cooking yields remains high and uncontrolled. To understand the biochemical effects of postslaughter processing on fat loss during cooking, this study characterizes for the first time the protein expression of fatty liver during chilling using a proteomic approach. For this purpose the proteins were separated according to their solubility: the protein fraction soluble in a buffer of low ionic strength (S) and the protein fraction insoluble in the same buffer (IS). Two-dimensional electrophoresis was used to analyze the S fraction and mass spectrometry for the identification of spots of interest. This analysis revealed 36 (21 identified proteins) and 34 (26 identified proteins) spots of interests in the low-fat-loss and high-fat-loss groups, respectively. The expression of proteins was lower after chilling,

I was following Microsofts advice to install WinDbg as a post mortem debugger, but didnt get the expected results. It turns out that WinDbg x64 version will register itself as the post mortem debugger for 64-bit and 32-bit processes, and not just for 64-bit processes: Of course, WinDbg x86 version will register itself only for…

For some time there have been suspicions that brain weight is reduced consistent with the structural change suggested by the ventricular enlargement documented in radiological studies, but the findings have been variable between postmortem samples. Harrison et al have now clearly established that the effect is real (2% of brain weight, p = 0.04) and that it applies approximately equally to males and females.. What is the meaning of the finding? As Harrison et al argue the result encourages a continuing search for the histological and molecular correlates of schizophrenia, but it also sets limits on what can be expected from such a search. There has been recent interest in the question of what component of the disease deteriorates. Some patients get worse with time and some of these never experience a restitutio ad integrum (complete recovery). If a structural correlate were identified this finding would have clinical and potential therapeutic significance. But if the implication is that ...

Post-mortem interval (PMI) is the time elapsed since a person died. Currently there is no accurate method for determining PMI of skeletal remains. Existing methods are best suited for deciding whether a bone is of forensic ...

Unidentified white male found near Holly, Colorado. Unidentified male found in ditch and was possibly transient. No identifying characteristics. Individual may have been in the area since October 30th, 2015. Cause of death undetermined pending additional investigation. Weight: abt. 180 Height: 72 inches Estimated postmortem interval: 5 weeks Hair: Brown (Most not present due to submersion in water) Facial Hair: Brown and grey stubble

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Now our research suggests that the mothers immune system may be yet another factor or a trigger in those already predisposed, says lead investigator Harvey Singer, M.D., director of pediatric neurology at Hopkins Childrens. Researchers caution that the findings neednt be cause for alarm, but should be viewed instead as a step forward in untangling the complex nature of autism.. Mostly anecdotal past evidence of immune system involvement has emerged from unusual antibody levels in some autistic children and from postmortem brain tissue studies showing immune abnormalities in areas of the brain. Antibodies are proteins the body makes in response to viruses and bacteria or sometimes mistakenly against its own tissues. Yet, the majority of children with autism have no clinical evidence of autoimmune diseases, which prompted researchers to wonder whether the antibodies transferred from mother to child during pregnancy could interfere with the fetal brain directly. To test their hypothesis, the ...

Original design sketch.I was trying to stay away from writing a post mortem for this game because I dont want to accept that its over. Multiplatform support, multiplayer networking, a 3 (occasionally 2, but usually 1) man development team and a very short project deadline; this was clearly one of the most challenging projects I…

We are currently developing human dissociated astrocytic and microglial cultures (and slice cultures) from adult biopsy and post-mortem human brain.. ...

|p|This kit contains the necessary reagents and hardware for postmortem fingerprint treatment and restoration. The tissue builder solution is packaged in disposable vials for convenience. A postmortem inking tool and record strips are included for recordi

Paul Fornes, Domitille Callon, Laurent Andreoletti. Study Group for Forensic and Post-Mortem Microbiology de la société européenne de microbiologie. Protocole de prélèvements post-mortem.. Société Française de Médecine Légale, Mar 2018, Paris, France. ⟨hal-03245373⟩ ...

Postmortem Lover is a single album by Spleen Saint. Released: 2009. Genres: Melodic Black Metal, Death Metal. Labels: Independent. Songs: Postmortem Lover

A blog post discussing research examing the epigenetic regulation of EN-2 gene in cases of autism focused on post-mortem cerebellar samples

Skip areas in focal steatosis describes a newly proposed subsegmental type of focal steatosis, which differs in both extent and topography from the more classic lobar or segmental type of focal steatosis.. In the subsegmental type of steatosis, fatty infiltration can be considered homogeneous through-out the liver, with the exception of small flattened portions of less affected parenchyma, called skip areas. These regions are mainly located in the subcapsular areas or along the interlobar fissures or the gallbladder bed.. Observations using ultrasound in vivo, as well as on postmortem in vitro angiograms, suggest that both the extent and topography of these skip areas can be explained by local differences in vascular anatomy. ...

[On the effectiveness of combined therapy of agonal states in severe shock and hemorrhage]. Grekovs Bulletin of Surgery FSBEI HE I.P. Pavlov SPbSMU MOH Russia 0042-4625 PMID:13780332

Synonyms for autopsist in Free Thesaurus. Antonyms for autopsist. 10 synonyms for autopsy: postmortem, dissection, postmortem examination, necropsy, necropsy, PM, postmortem examination, post-mortem examination, postmortem.... What are synonyms for autopsist?

The autopsy remains the criterion standard for quality assessment in medicine. Only then are physicians able to see for themselves the true nature of trauma and disease in a person, assess the efficacy of various treatments, and witness the nature of changes within the body as a result of age and lifestyle.

The Department of Primary Industries and Regional Development has created a sampling and post-mortem guide to assist veterinarians investigating pig disease. You can download a PDF copy from the Documents link on this page, or WA veterinarians can request a laminated hard copy by emailing [email protected].

A post-mortem examination this morning of a newborn girl, whose body was dumped in a Lower Hutt back yard, is expected to shed light on the circumstances ar

Your one-stop online shop for new and vintage RPG products from the top publishers, delivered fresh to your desktop in electronic format.

Definition : Hooks designed to temporarily secure tissues or organs by catching and/or pulling them during dissection, excision, and/or to perform other postmortem procedures. These hooks typically consist of sturdy handheld manual stainless steel instruments with a shank slightly bent near the distal end (usually at angles from 135 to 180 degrees) and finished in a blunt or sharp tip. Postmortem hooks are usually supplied with a hammer at the other end of the hook. They are used during postmortem procedures (e.g., for bone cutting).. Entry Terms : Postmortem Hooks. UMDC code : 32845 ...

The fact that a right aortic arch with a constricting vascular ring was found in a body that had been bequeathed to the Department of Anatomy enabled a detailed correlation to be made between the clinical history, previous radiological examinations, and the postmortem findings.

Details of the Malayalam Movie: Movie Name: Postmortem | പോസ്റ്റ്മോർട്ടം , Composer: KJ Joy | കെ ജെ ജോയ്‌ , Lyricist: Poovachal Khader | പൂവച്ചല്‍ ഖാദര്‍ , Director: Sasi Kumar | ശശികുമാര്‍

User Impact. - Detection. - Resolution. - Duration/Timeline. - What Went Well? - What Went Poorly? - Where We Got Lucky? - Action Items. 2 hours. 2019-12-05 (all times PDT) 09:45 Branch gh-pages deleted during clean up of repository branches. 10:21 GitHub issue filed stating that docs are not available. 10:45 Team responds to issue. 10:55 Branch has been republished 11:45 GitHub is serving docs again ...

At the end of my time in London I had the chance to sit in on the new SANS SEC580 class (Metasploit Kung Fu for Enterprise Pen Testing). This 2-day class is designed to show students how to apply the incredible capabilities of the Metasploit Framework in a comprehensive penetration testing and vulnerability assessment regimen, according…

There are a lot of tools available to simplify debugging GStreamer applications at runtime. Unfortunately, the situation is quite different, once an application crashes. While gdb can be used to access all the data structures, interpreting the data can be difficult and time consuming. This talk ...

aah Fischer, id completely fogot about him, unremarkable really,considering that he will go down asone of our most forgettable players in history.it would be nice if you could point to a moment in a game and say ....remember fischer doing this or that.........but you cant, he was totally anonymous. hewill go down in the same list as trevor senior in that respect. or boersma,bent, etc etc etc its a long list believe me ...

Intro: As part of an improved investment process, I will try to write better post mortem analysis after exiting an investment. I did this in the past especially for bad investments but I plan to do this now for every investment that I fully exit. Interestingly, very few fund mangers talk or write in detail…

106, 87: Create a histogram on how well ritual meetings went during the iteration, 9: Team members brainstorm in 4 categories to quickly list issues, 11, 14

The doctrine of purgatory from its earliest days has served the purpose of providing theological grounds for extending the hope of salvation to a wider range of persons. In its traditional form, however, it has not been understood as a second chance for salvation after death, but rather, only as chance for postmortem transformation and purging for persons who die in grace. Nevertheless, it is often popularly understood as a second chance to obtain salvation. This chapter explores the connections between the traditional doctrine of purgatory and theories of postmortem salvation. It cites several theologians who have construed purgatory in those terms, and argues that the traditional view should be modified to allow for postmortem conversion.

Postmortem brains from individuals with autism have astrocytes that are smaller but denser than in control brains, according to a study published 21 September in the Journal of Neuroinflammation. The researchers found similar alterations in a mouse that lacks the autism-linked gene NLGN3.

Read about a post-mortem brain study of Parkinsons disease showing altered levels of the LRRK2 protein are associated with different stages of the disease.

Bekris LM, Galloway NM, Montine TJ, Schellenberg GD, Yu C-E. 2010. APOE mRNA and protein expression in postmortem brain are modulated by an extended haplotype structure.. Am J Med Genet B Neuropsychiatr Genet. 153B(2):409-417. ...

Your one-stop online shop for new and vintage RPG products from the top publishers, delivered fresh to your desktop in electronic format.

New Delhi, August 21 Former Union minister Shashi Tharoor had addressed Meher Tarar as "My darlingest" in letters written to her by the Congress leader, the prosecution told a Delhi court o