Looking for Positron-emission tomography? Find out information about Positron-emission tomography. see PET scan PET scan or positron emission tomography , a medical imaging technique that monitors metabolic, or biochemical, activity in the brain and other... Explanation of Positron-emission tomography
see also Fluoroethyl Tyrosine Positron Emission Tomography Besides the advantages of hybrid positron emission tomography-computed tomography imaging, this dual-modality scanning may produce their own specific artifacts due to different causes, such as metallic implants, respiratory motion, contrast medium and truncation. Proper patient preparation is required to minimize the potential artifactual uptake patterns that make reporting difficult. It is important to learn about proper quality control, imaging and reconstruction and to be familiar with potential artifacts and, pitfalls for the accurate interpretation of F-fluorodeoxyglucose positron emission tomography-computed tomography 1). It is a highly sensitive and specific modality for detection of bone metastases in patients with high-risk prostate cancer. It is more specific than 18F-Fluoride PET alone and more sensitive and specific than planar and SPECT bone scintigraphy (BS). Detection of bone metastases is improved by SPECT compared with ...
We examined lateral geniculate nucleus (LGN) degeneration as an indicator for possible diagnosis of glaucoma in experimental glaucoma monkeys using positron emission tomography (PET). Chronic intraocular pressure (IOP) elevation was induced by laser trabeculoplasty in the left eyes of 5 cynomolgus monkeys. Glial cell activation was detected by PET imaging with [11C]PK11195, a PET ligand for peripheral-type benzodiazepine receptor (PBR), before and at 4 weeks after laser treatment (moderate glaucoma stage). At mild, moderate, and advanced experimental glaucoma stages (classified by histological changes based on the extent of axonal loss), brains were stained with cresyl violet, or antibodies against PBR, Iba-1 (a microglial marker), and GFAP (an activated astrocyte marker). In laser-treated eyes, IOP was persistently elevated throughout all observation periods. PET imaging showed increased [11C]PK11195 binding potential in the bilateral LGN at 4 weeks after laser treatment; the increase in the
This phase II trial studies how well chemotherapy based on positron emission tomography (PET) scan works in treating patients with stage I or stage II Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells and allow doctors to save the part of the body where the cancer started. Comparing results of diagnostic procedures, such as PET scan, done before, during, and after chemotherapy may help doctors predict a patients response to treatment and help plan the best treatment ...
This phase II trial studies how well chemotherapy based on positron emission tomography (PET) scan works in treating patients with stage I or stage II Hodgkin lymphoma. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. Radiation therapy uses high energy x-rays to kill cancer cells. Giving combination chemotherapy together with radiation therapy may kill more cancer cells and allow doctors to save the part of the body where the cancer started. Comparing results of diagnostic procedures, such as PET scan, done before, during, and after chemotherapy may help doctors predict a patients response to treatment and help plan the best treatment ...
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [(18)F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase (18)F-click radiolabeling and solid-phase radiolabeling using 4-[(18)F]fluorobenzoic and 2-[(18)F]fluoropropionic acids. Here we compare the three different radiolabeling approaches and report the effects on PET imaging and pharmacokinetics. The prosthetic groups did have an effect; metabolites with significantly different polarities were observed.
With the increasing utilization of integrated positron-emission tomography/computed tomography (PET/CT) using | A. D. Culverwell, Andrew Scarsbrook, Fahmid U. Cho | Clinical Radiology |
Abstract: Objective To evaluate the correlation of the positron emission tomography/magnetic resonance imaging (PET/MR) parameters with the pathological differentiation of head and neck squamous cell carcinoma(HNSCC) and the diagnostic efficiencies of PET/MR parameters. Methods Patients with clinical suspicion of HNSCC were included and underwent PET/MR scan. HNSCC was pathologically confirmed in all these patients. The PET/MR examination included PET and MR sequences of diffusion-weighted imaging (DWI) and T2-and T1-weighted imaging. The multiple parameters of PET/MR included the mean values of apparent diffusion coefficient(ADCmean) and the maximum and mean values of standardized uptake value (SUVmax and SUVmean) were measured and estimated. The correlations of all the parameters and distribution between the different tumor differentiation groups were analyzed. Logistic regression was utilized to build the model as the PET/MR combined parameter for predicting the differentiation by multiple ...
Positron Emission Tomography (PET) Scanners Market size will reach xx million US$ by 2029, from xx million US$ in 2018, at a CAGR of xx% during the forecast period. In this study, 2018 has been considered as the base year and 2016 - 2026 as the forecast period to estimate the market size for Positron Emission Tomography (PET) Scanners .. This industry study presents the Positron Emission Tomography (PET) Scanners Market size, historical breakdown data 2014-2019 and forecast 2016 - 2026. The Private Plane production, revenue and market share by manufacturers, key regions and type; The consumption of Positron Emission Tomography (PET) Scanners Market in volume terms are also provided for major countries (or regions), and for each application and product at the global level.. This Press Release will help you to understand the Volume, growth with Impacting Trends. Click HERE To get SAMPLE PDF (Including Full TOC, Table & Figures) at https://www.xploremr.com/connectus/sample/879. Positron Emission ...
The presence of bulky disease in Hodgkin lymphoma (HL), traditionally defined with a 1-dimensional measurement, can change a patients risk grouping and thus the treatment approach. We hypothesized that 3-dimensional measurements of disease burden obtained from baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), would more accurately risk stratify patients. To test this hypothesis, we reviewed pretreatment PET-CT scans of patients with stage I-II HL treated at our institution between 2003-2013. Disease was delineated on pre-chemotherapy PET-CT scans by two methods: 1) manual contouring, and 2) sub-thresholding of these contours to give the tumor volume with SUV≥2.5. MTV and TLG were extracted from the threshold volumes (MTVt, TLGt), as well as from the manually contoured soft-tissue volumes (MTVst, TLGst). At a median follow-up time of 4.96 years for the 267 patients evaluated, ...
Objective: The objective of this study was to compare the accuracy of calculating the primary tumor volumes using a gradient-based method and fixed threshold methods on the standardized uptake value (SUV) maps and the net influx of FDG (Ki) maps from positron emission tomography-computed tomography (PET-CT) images.. Materials and Methods: Newly diagnosed patients with head and neck cancer were recruited, and dynamic PET-CT scan and T2-weighted magnetic resonance imaging were performed. The maps of Ki and SUV were calculated from PET-CT images. The tumor volumes were calculated using a gradient-based method and a fixed threshold method at 40% of maximal SUV or maximal Ki. Four kinds of volumes, VOLKi-Gra (from the Ki maps using the gradient-based method), VOLKi-40% (from the Ki maps using the threshold of 40% maximal Ki), VOLSUV-Gra (from the SUV maps using the gradient-based method), and VOLSUV-40% (from the SUV maps using the threshold of 40% maximal SUV), were acquired and compared with VOLMRI ...
Using statistical methods the reconstruction of positron emission tomography (PET) images can be improved by high-resolution anatomical information obtaine
Prostate cancer is a common cancer in men and continues to be a major health problem. Imaging plays an essential role in the clinical management of patients. An important goal for prostate cancer imaging is more accurate disease characterization through the synthesis of anatomic, functional, and molecular imaging information. Developments in imaging technologies, specifically magnetic resonance imaging (MRI) and positron emission tomography (PET)/computed tomography (CT), have improved the detection rate of prostate cancer. MRI has improved lesion detection and local staging. Furthermore, MRI allows functional assessment with techniques such as diffusion-weighted MRI, MR spectroscopy, and dynamic contrast-enhanced MRI. The most common PET radiotracer, (18)F-fluorodeoxyglucose, is not very useful in prostate cancer. However, in recent years other PET tracers have improved the accuracy of PET/CT imaging of prostate cancer. Among these, choline (labeled with (18)F or (11)C), (11)C-acetate, and ...
TY - JOUR. T1 - Follow-up of radial arterial catheterization for positron emission tomography studies. AU - Jons, Peter H.. AU - Ernst, Monique. AU - Hankerson, James. AU - Hardy, Kristina. AU - Zametkin, Alan J.. PY - 1997/6/24. Y1 - 1997/6/24. N2 - Radial arterial catheterization is needed for repeated arterial blood samples to construct tracer input curves of positron emission tomography (PET) scans (Herscovitch [1993]: Rheum Dis Clin North Am 19:765-794). Complications resulting from such short-term catheterizations are rare. Sixteen investigators followed 106 subjects who had arterial lines placed in the context of a PET study. Abnormalities were reported in 8 of 106 (7.5%) cases. Of these eight cases, three (37.5%) were inpatients diagnosed with anorexia nervosa, a condition that may represent a risk factor. All abnormalities were benign, did not affect motor function, and did not require medical intervention.. AB - Radial arterial catheterization is needed for repeated arterial blood ...
METHODS: The current study included 132 patients, who were operated on between July 2007 and April 2013, for renal cell carcinoma (RCC) and received 18FDG-PET/CT scans for restaging purposes. Ninety (68.2%) of the patients were male and 42 (31.8%) were female, with a mean age of 60.7 years and standard deviation ±11.9 (range min: 28, max: 86). The patients were required to fast for 6 hours prior to scanning, and whole-body PET scanning from the skull base to the upper thighs was performed approximately 1 hour after the intravenous injection of 555 MBq of F-18 FDG. Whole body CT scanning was performed in the cranio-caudal direction. FDG-PET images were reconstructed using CT data for attenuation correction. Suspicious recurrent or metastatic lesions were confirmed by histopathology or clinical follow-up ...
We hypothesized that quantitative PET parameters may have predictive value beyond that of traditional clinical factors such as the International Prognostic Score (IPS) among Hodgkins disease (HD) patients. Thirty HD patients treated at presentation or relapse had staging and interim-treatment PET-CT scans. The majority of patients (53%) had stage III-IV disease and 67% had IPS ≥ 2. Interim-treatment scans were performed at a median of 55 days from the staging PET-CT. Chemotherapy regimens used: Stanford V (67%), ABVD (17%), VAMP (10%), or BEACOPP (7%). Hypermetabolic tumor regions were segmented semiautomatically and the metabolic tumor volume (MTV), mean standardized uptake value (SUVmean), maximum SUV (SUVmax) and integrated SUV (iSUV) were recorded. We analyzed whether IPS, absolute value PET parameters or the calculated ratio of interim- to pre-treatment PET parameters were associated with progression free survival (PFS) or overall survival (OS). Median follow-up of the study group was 50 months.
TY - JOUR. T1 - A hybrid nanoparticle probe for dual-modality positron emission tomography and magnetic resonance imaging. AU - Choi, Jin Sil. AU - Park, Jeong Chan. AU - Nah, Hyunsoo. AU - Woo, Seungtae. AU - Oh, Jieun. AU - Kim, Kyeong Min. AU - Cheon, Gi Jeong. AU - Chang, Yongmin. AU - Yoo, Jeongsoo. AU - Cheon, Jinwoo. PY - 2008/8/4. Y1 - 2008/8/4. N2 - (Figure Presented) Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ability. Sentinel lymph nodes are clearly identified in the fusion image (see picture; I: injection site) because of the complementary nature of the techniques, which makes accurate anatomical information and fault-free diagnosis possible.. AB - (Figure Presented) Creating a good image: A probe for combined positron emission tomography (PET) and magnetic resonance imaging (MRI) has high colloidal stability and demonstrates facile conjugation ...
Positron emission tomography (PET) scan - Overview covers definition, risks, results of this imaging test used to diagnose disease and assess treatment.
As a nuclear approach, Positron Emission Tomography (PET) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. There are certain limitations to this technique such as normal tissue uptake. Therefore, it has been recommended that patients prepare before scanning. Fasting for a short while before PET imaging is an example of such preparation. In this paper, we attempted to collect the studies evaluating the effects of fasting in the three sections of cardiac, brain and abdominal PET imaging. Conclusively, we found that the effects of fasting on PET imaging can be different depending on the type of PET scanning, radiotracer, patients diseases, fasting duration and in case of any additional dietary plans. It is proposed that further study be conducted on this subject in order to determine such effects in more detail.
We offer in vivo micro positron emission tomography (PET) study design, execution and data analysis across a broad spectrum of disease models and analytic techniques. Our imaging experts and disease area experts design and execute PET studies for maximal clinical relevance, statistical power, and throughput. Our PET studies are performed using a Siemens Inveon scanner.. Positron emission tomography (PET) is a nuclear medicine imaging technique that generates 3D images of an injected PET radioisotope-labeled molecule in the body. Radiotracer distribution is detected via emitted gamma photons resulting from positron-electron annihilation. PET imaging in the preclinical setting (micro-PET) is increasingly being used in drug discovery to study disease biology and biodistribution and kinetics of biologic molecules.. ...
Press Release issued Sep 7, 2017: Future Market Insights delivers key insights on the global Positron Emission Tomography scanners market in a new report titled, Positron Emission Tomography (PET) Scanners Market: Global Industry Analysis and Opportunity Assessment, 2016-2026. In terms of revenue, the global Positron Emission Tomography (PET) scanners market is projected to register a healthy CAGR of 4.7% over the forecast period.
OBJECTIVE: The serotonin transporter (5-HTT) is a key target for selective serotonin reuptake inhibitors and may be involved in the pathophysiology of major depression. It is now possible to image 5-HTT directly in the human brain, but results from studies of acutely depressed patients have been inconsistent. The purpose of this study was to determine whether abnormalities in 5-HTT might be present in recovered depressed patients. METHOD: The authors measured the binding potential of 5-HTT using [11C]DASB in conjunction with positron emission tomography (PET) in 24 medication-free, recovered depressed male patients and 20 healthy male comparison subjects. The regional estimates of binding potential were obtained using a metabolite-corrected plasma input function method followed by Logan analysis, with the cerebellum as a reference region. RESULTS: The authors found no significant difference in the binding potential of [11C]DASB between the recovered depressed patients and healthy comparison subjects in
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic:
The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium . Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However, even though the 80-100 min post-injection time window did not show the smallest bias numerically, the disagreement between SUVR and DVR varied least between regions during this time. In conclusion, our findings suggest a regional component to the bias of SUVR related to the ...
The current study showed that CIRT performed at our institute could treat inoperable bone and soft-tissue tumors with an acceptable recurrence rate as low as that in previous reports [8-10]. CIRT induced a significant decrease of FDG accumulation in the target tumors, and the post-Tx SUVmax in the recurrence group was significantly higher than that in the no recurrence group. These results suggested that CIRT could downregulate the tumor metabolism, and the tumors that exhibited decreased glucose transport activity following CIRT showed a reduced risk of local recurrence. Meanwhile, the tumor size was hardly changed after CIRT, and seemed to be inappropriate for evaluating the response to the treatment, which was consistent with previous reports showing that the SUV from FDG-PET/CT was superior to changes in tumor size for predicting tumor necrosis induced by neoadjuvant chemotherapy [12].. While a favorable effect of CIRT to reduce the tumor activity was shown, the present study also showed ...
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. ...
Purpose/Introduction: Use of brain PET studies in multicentre trials or as a quantitative imaging biomarker for (automated) differential diagnosis of neurogenerative diseases require harmonized quantitative image characteristics. In this study we explored the feasibility of developing a harmonizing performance standard for brain PET studies on state of the art PET/CT systems. Subjects & Methods: In this exploratory study 6 state of the art PET/CT systems were included: Philips Gemini TF, Ingenuity TF and digital Vereos systems, 2 Siemens Biograph mCTs and a GE 710. Only systems with EARL compliant (calibration and image quality) performances were included. A 30 min dynamic PET scan of the 3D Hoffmann brain phantom was acquired. The phantom was filled with an exact known FDG stock solution (aimed at 40 kBq/mL). Each scan was reconstructedusing various clinically relevant reconstruction settings. Depending on PET/CT system reconstruction settings were varied as follows: time of flight (TOF) ...
TY - JOUR. T1 - Differential diagnosis of lung tumor with positron emission tomography. T2 - A prospective study. AU - Kubota, K.. AU - Matsuzawa, T.. AU - Fujiwara, T.. AU - Ito, M.. AU - Hatazawa, J.. AU - Ishiwata, K.. AU - Iwata, Ren. AU - Ido, T.. PY - 1990/12/1. Y1 - 1990/12/1. N2 - To predict the nature of non-calcifying lung tumors, we performed a prospective study of 46 cases with L-[methyl 11C]methionine (MET, 24 cases) and 18F-fluorodeoxyglucose (FDG, 22 cases) using positron emission tomography (PET). Mean tumor/muscle radioactivity ratios are 5.3 ± 2.0 (n = 14) for malignant and 1.9 ± 0.9 (n = 10) for benign with MET (p , 0.001), and 4.4 ± 2.2 (n = 12) and 1.5 ± 0.3 (n = 10), respectively, with FDG (p , 0.001). The ratios indicate that malignant tumors have higher metabolic demand than benign lesions. Tumors less than 1 cm in diameter were difficult to accurately evaluate due to PET resolution. Compared to the diagnosis at pathology, the MET study showed a sensitivity of 93% ...
Single arm, open label, Phase IB study of indibulin capsules in subjects with advanced solid tumors; eligible subjects will have a baseline PET scan sho
The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) have been used to assess brain tumors. Our aim was to compare their diagnostic accuracies in patients with suspected cerebral glioma. Ninety patients with suspicion of glioma based on previous CT/MRI, who underwent NH3 PET, MET PET and FDG PET, were prospectively enrolled in the study. The reference standard was established by histology or clinical and radiological follow-up. Images were interpreted by visual evaluation and semi-quantitative analysis using the lesion-to-normal white matter uptake ratio (L/WM ratio). Finally, 30 high-grade gliomas (HGG), 27 low-grade gliomas (LGG), 10 non-glioma tumors and 23 non-neoplastic lesions (NNL) were diagnosed. On visual evaluation, sensitivity and specificity for differentiating tumors from NNL were 62.7% (42/67) and 95.7% (22/23) for
AIM: To evaluate integrated 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) positron-emission tomography (PET)/magnetic resonance imaging (MRI), in comparison with the standard technique, integrated F-18-FDG-PET/computed tomography (CT), in preoperative staging of oesophageal or gastroesophageal junctional cancer.. MATERIALS AND METHODS: In the preoperative staging of 16 patients with oesophageal or gastroesophageal junctional cancer, F-18-FDG-PET/MRI was performed immediately following the clinically indicated F-18-FDG-PET/CT. MRI-sequences included T1-weighted fat-water separation (Dixons technique), T2-weighted, diffusion-weighted imaging (DWI), and gadolinium contrast-enhanced T1-weighted three-dimensional (3D) imaging. PET was performed with F-18-FDG. Two separate teams of radiologists conducted structured blinded readings of F-18-FDG-PET/MRI or F-18-FDG-PET/CT, which were then compared regarding tumour measurements and characteristics as well as assessment of inter-rater agreement (Cohens ...
PET/CT is generally not useful in CLL/SLL but can assist in directing nodal biopsy if Richters transformation is suspected. a. Initial staging: PET/CT scan considered useful in selected cases. b. Restaging after completion of treatment: imaging should be performed whenever there are clinical indications. If PET/CT is used in follow-up, progressive disease should be histologically documented (e.g., biopsy) to rule out transformation c. Non-gastric MALT lymphoma, marginal zone lymphoma (nodal, splenic), a. Initial staging: PET/CT scan considered useful in selected cases. a. Initial staging: PET/CT scan considered useful under certain a. Initial staging: PET/CT scan considered essential. b. Restaging after completion of treatment: repeat all positive studies. Biopsy of PET-positive sites is recommended before changing course of treatment. The optimum timing of PET/CT is unknown; however, waiting a minimum of 8 weeks to repeat PET/CT is suggested. False positives may occur due to ...
The presence of lymph node metastases at the time of prostate cancer diagnosis has significant implications for treatment. According to current guidelines from the National Comprehensive Cancer Network, men with positive lymph nodes on initial staging imaging should be offered treatment with androgen deprivation (± abiraterone) along with consideration for external beam radiation therapy [1]. In contrast, men with clinically localised high‐ or very‐high‐risk prostate cancer have the option of undergoing radical prostatectomy. Unfortunately, currently available diagnostic imaging modalities (i.e. contrast‐enhanced CT and MRI) fall short in their ability to accurately identify lymph node metastases, which are often small and difficult to discern from other structures within the pelvis. Thus, there exists a conundrum: if we cannot accurately detect lymph node involvement, how can we appropriately manage it?. In this edition of the BJUI, Leeuwen et al. [2] report on the utility of molecular ...
The behavioral and psychophysiological alterations during recall in patients with trauma disorders often resemble phenomena that are seen in hypnosis. In studies of emotional recall as well as in neuroimaging studies of hypnotic processes similar brain structures are involved: thalamus, hippocampus, amygdala, medial prefrontal cortex, anterior cingulate cortex. This paper focuses on cross-correlations in traumatic recall and hypnotic responses and reviews correlations between the involvement of brain structures in traumatic recall and processes that are involved in hypnotic responsiveness ...
Purpose. To evaluate the prognostic value of metabolic parameters and bone marrow uptake (BMU) patterns on pretherapeutic 18-F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in pediatric patients with neuroblastoma (NB).. Patients and methods. Forty-seven pediatric patients with newly diagnosed neuroblastoma who underwent 18F-FDG PET/CT were retrospectively reviewed. Clinicopathological factors and metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and bone marrow uptake patterns on PET/CT were compared to predict recurrence-free survival (RFS) and overall survival (OS) by univariate and multivariate analysis.. Results. During the follow-up period, 27 (57.4%) patients experienced recurrence. MTV (P = 0.001), TLG (P = 0.004) and BMU patterns (P = 0.025) remained significant predictive factors for tumor recurrence, along with tumor size, histology, stage, lactate ...
Positron emission tomography (PET) allows for the measurement of cerebral blood flow (CBF; based on [15O]H2O) and cerebral metabolic rate of glucose utilization (CMRglu; based on [18 F]-2-fluoro-2-deoxy-d-glucose ([18 F]FDG)). By using kinetic modeling, quantitative CBF and CMRglu values can be obtained. However, hardware limitations led to the development of semiquantitive calculation schemes which are still widely used. In this paper, the analysis of CMRglu and CBF scans, acquired on a current state-of-the-art PET brain scanner, is presented. In particular, the correspondence between nonlinear as well as linearized methods for the determination of CBF and CMRglu is investigated. As a further step towards widespread clinical applicability, the use of an image-derived input function (IDIF) is investigated. Thirteen healthy male volunteers were included in this study. Each subject had one scanning session in the fasting state, consisting of a dynamic [15O]H2O scan and a dynamic [18 F]FDG PET scan,
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Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses on a randomised comparison of conventional radiotherapy plann
Purpose: To assess various volume based PET quantification metrics including: metabolic tumor volume (MTV) and total lesion glycolysis (TLG) with different thresholds as well as background activity based PET metrics (Background Subtracted Lesion activity (BSL) and Volume (BSV)) as prognostic markers for progression free and overall survival (PFS, OS) in early stage I and II non-small cell lung cancer (NSCLC) after resection. Patients and Methods: 133 patients received an adequate FDG PET/CT scan prior to surgery between January 2003 and December 2010. All PET activity metrics showed a skewed distribution and were log-transformed before calculating the Pearson correlation coefficients (PCC). Survival tree analysis was used to discriminate between high and low risk patients and to select the most important prognostic markers. Akaike information criterion (AIC) was used to compare two uni-variate models. Results: Within the study time 36 patients died from NSCLC and 26 patients from other causes. ...
Pietrini, Pietro and Guazzelli, Mario and Sarteschi, Pietro and Grady, Cheryl L. and Haxby, James V. and Swedo, Susan E. and Rapoport, Stanley I. and Schapiro, Mark B. Positron Emission Tomography (PET) as a tool to investigate cerebral glucose metabolism in neurologic and psychiatric disorders. Studies in dementia of the Alzheimer type and obsessive-compulsive disorder. In: Psychiatry and advanced technologies (ed. by L. Ravizza). Raven Press. ISBN 0781700035 (1993) Full text not available from this repository ...
Solid tumors are hypoxic with altered metabolism, resulting in secretion of acids into the extracellular matrix and lower relative pH, a feature associated with local invasion and metastasis. Therapeutic and diagnostic agents responsive to this microenvironment may improve tumor-specific delivery. Therefore, we pursued a general strategy whereby caged small-molecule drugs or imaging agents liberate their parent compounds in regions of low interstitial pH. In this manuscript, we present a new acid-labile prodrug method based on the glycosylamine linkage, and its application to a class of positron emission tomography (PET) imaging tracers, termed [(18)F]FDG amines. [(18)F]FDG amines operate via a proposed two-step mechanism, in which an acid-labile precursor decomposes to form the common radiotracer 2-deoxy-2-[(18)F]fluoro-d-glucose, which is subsequently accumulated by glucose avid cells. The rate of decomposition of [(18)F]FDG amines is tunable in a systematic fashion, tracking the pKa of the ...
Our group develops basic technologies and complete imaging systems that are able to track molecules and cells in living beings. We have been highly successful in developing Single Photon Emission Computed Tomography (SPECT) systems for small animals that provide images of molecular processes in organs and tumors with a world record spatial and temporal resolution (U-SPECT, see Fig. 1). Recently, we have developed a new scanner geometry that can not only image SPECT tracer molecules but is also able to visualize PET (Positron Emission Tomography) tracer molecules at very high resolutions at the same time (VECTor, see Fig. 2). This gives many unique opportunities to develop new pharmaceuticals and biomarkers for treatment and diagnosis of e.g. cancer, brain and cardiac disease. Our SPECT/PET scanner is also equipped with a CT in order to combine the functional information obtained with SPECT/PET with the anatomical information provided by the CT scan. We conduct research on all aspects of our ...
The concept of positron emission tomography (PET) imaging revolves around the measurement of a patients in vivo radiotracer distribution. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body via biologically active molecules. As such, PET imaging can be described via a line-integral model of acquisition [1]. PET data are collected as projections in sinograms or listmode format [2]. The raw data collected by a PET scanner are a list of coincidence events representing near-simultaneous detection, each coincidence event represents a line in space connecting the two detectors along which the positron emission occurred. While one can employ the inverse Radon transform to recover tomograms from acquired PET data, such an approach can be unstable, particularly when dealing with noise-contaminated data [3]. Therefore, the filtered back projection algorithm, which is a stabilized and discretized version of the inverse ...
What?. Positron emission tomography, also called PET imaging or a PET scan, is a diagnostic examination that uses signals emitted by radioactive tracers to construct images of the distribution of the tracers (positrons) in the human body. Positrons are tiny particles emitted from a radioactive substance administered to the patient. The subsequent images of the human body developed with this technique are used to evaluate a variety of diseases.. When? What are some common uses of the procedure?. PET scans are used most often to detect cancer and to examine the effects of cancer therapy by characterizing biochemical changes in the cancer. These scans can be performed on the whole body. PET scans of the heart can be used to determine blood flow to the heart muscle and help evaluate signs of coronary artery disease. PET scans of the heart can also be used to determine if areas of the heart that show decreased function are alive rather than scarred as a result of a prior heart attack, called a ...
Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Positron Emission Tomography
Time-of-flight (TOF) positron-emission tomography (PET) has increasingly been adopted as an important quantitative imaging tool in basic and clinical applications. Improving image quality via advanced image reconstruction methods remains an area of active interest. In particular, it is of practical... Read more ...
Future Market Insights delivers key insights on the global Positron Emission Tomography scanners market in a new report titled, „Positron Emission Tomography (PET) Scanners Market: Global Industry Analysis and Opportunity Assessment, 2016-2026. In terms of revenue, the global Positron Emission Tomography (PET) scanners market is projected to register a healthy CAGR of 4.7% over the forecast period.. According to Future Market Insights, growing occurrences of chronic disorders and increasing penetration of PET machines is expected to drive overall growth of the global Positron Emission Tomography (PET) scanners market during the forecast period. Rising demand for effective diagnostic techniques across the globe and expanded applications for PET in the field of oncology are further expected to boost the growth of the global Positron Emission Tomography (PET) scanners market between 2016 and 2026. However, a short half-life and low supply of radiopharmaceuticals is likely to restrict market ...
Hybrid PET/CT and SPECT/CT Imaging / with DVD auf frohberg.de - Hybrid PET/CT and SPECT/CT Imaging: A Teaching File presents a complete book on...
The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer : clinical and pathological factors influencing it(審査報告)The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer : clinical and pathological factors influencing it(審査報告) ...
Objective: The objective of this study was to compare the accuracy of calculating the primary tumor volumes using a gradient-based method and fixed threshold methods on the standardized uptake value (SUV) maps and the net influx of FDG (Ki) maps from positron emission tomography-computed tomography (PET-CT) images. Materials and Methods: Newly diagnosed patients with head and neck cancer were recruited, and dynamic PET-CT scan and T2-weighted magnetic resonance imaging were performed. The maps of Ki and SUV were calculated from PET-CT images. The tumor volumes were calculated using a gradient-based method and a fixed threshold method at 40% of maximal SUV or maximal Ki. Four kinds of volumes, VOLKi-Gra (from the Ki maps using the gradient-based method), VOLKi-40% (from the Ki maps using the threshold of 40% maximal Ki), VOLSUV-Gra (from the SUV maps using the gradient-based method), and VOLSUV-40% (from the SUV maps using the threshold of 40% maximal SUV), were acquired and compared with VOLMRI ...
TY - JOUR. T1 - Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement. AU - Iwamuro, Masaya. AU - Okada, Hiroyuki. AU - Takata, Katsuyoshi. AU - Shinagawa, Katsuji. AU - Fujiki, Shigeatsu. AU - Shiode, Junji. AU - Imagawa, Atsushi. AU - Araki, Masashi. AU - Morito, Toshiaki. AU - Nishimura, Mamoru. AU - Mizuno, Motowo. AU - Inaba, Tomoki. AU - Suzuki, Seiyu. AU - Kawai, Yoshinari. AU - Yoshino, Tadashi. AU - Kawahara, Yoshiro. AU - Takaki, Akinobu. AU - Yamamoto, Kazuhide. N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.. PY - 2012. Y1 - 2012. N2 - AIM: To investigate the capacity for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma. METHODS: This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten ...
Ly et al: CAA Predisposes to rt-PA Related Hhemorrhage Cerebral b-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage John V. Ly,1 Christopher C. Rowe,2 Victor L. Villemagne,2 Jorge A. Zavala,1 Henry Ma,1 Graeme OKeefe,2 Sylvia J. Gong,2 Rico Gunawan,1 Leonid Churilov,1 Tim Saunder,2 Uwe Ackerman,2 Henri Tochon-Danguy,2 and Geoffrey A. Donnan1,3 Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, ...
Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images obtained with the DL method with those obtained using a Gaussian filter. Fifty patients with a mean age of 64.4 (range, 19-88) years who underwent 18F-FDG PET/CT between April 2019 and May 2019 were included in the study. PET images were obtained with the DL method in addition to conventional images reconstructed with three-dimensional time of flight-ordered subset expectation maximization and filtered with a Gaussian filter as a baseline for comparison. The reconstructed images were reviewed by two nuclear medicine physicians and scored from 1 (poor) to 5 (excellent) for tumor delineation, overall image quality, and image noise. For the semi-quantitative analysis, standardized uptake values in tumors and healthy tissues were compared between images obtained using
BACKGROUND: Inflammation plays a key role in progression and destabilization of atherosclerotic plaque. [18F]-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a promising tool for visualizing inflammation of atherosclerotic plaque. Anti-inflammatory action is one of the pleiotropic effects of statins.. OBJECTIVE: We investigated whether simvastatin attenuates plaque inflammation by using 18FDG-PET co-registered with computed tomography.. METHODS and RESULTS: Forty-three consecutive subjects, who underwent 18FDG-PET for cancer screening and had 18FDG uptakes in the thoracic aorta and/or the carotid arteries, were randomized to either statin group receiving simvastatin (n=21) or diet group receiving dietary managements (n=22). The maximum standardized uptake values (SUVs) were measured in individual plaques, and were averaged for analysis of the subject-wise results. The responses were assessed after 3-month treatments. PET revealed 117 and 123 18FDG-positive plaques in the statin ...
F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used in the initial evaluation and response assessment of patients with Hodgkins lymphoma (HL). Its sensitivity for nodal and extranodal sites of disease can add to the staging information obtained with CT alone,1 and PET is valuable in the response assessment at the end of front-line therapy because it can distinguish active disease from fibrosis in residual masses. In fact, the goal of front-line therapy is now a PET-negative complete remission (CR).2 Interim PET scan, performed during the initial course of therapy, may also have prognostic significance,3 and treatment adapted to interim PET results is under investigation in ongoing clinical trials. The role of PET in the response assessment and management of relapsed and refractory HL is less well established than in the front-line setting. Up to 30 % of patients with HL will fail to respond to, or will relapse after, ...
A proportion of patients with pancreatic cancer never develop metastatic disease. We evaluated a role for (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in identifying a subset of patients with locally advanced pancreatic cancer (LAPC) who never develop metastatic disease and only experience local disease and may therefore benefit from local treatment intensification.
PubMedID: 23509326 | Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. | Annals of the American Thoracic Society | 2/1/2013
It has been well established that hepatocellular carcinomas (HCCs) accumulate [[sup 18]F]fluorodeoxy-glucose (FDG) to varying degrees; this is thought to be due to differing amounts of FDG-6-phosphatase activity. The purpose of this study was to evaluate the impact of FDG imaging on the management of patients diagnosed with hepatocellular carcinoma. We conducted a retrospective review of the clinical data of 91 consecutive patients diagnosed with HCC who underwent FDG-positron emission tomography (PET) imaging between August 1993 and March 2001. The patients were divided into two groups. In Group one 67 of 91 (74%) patients were evaluated for proven but untreated hepatic lesions using PET. In Group two the remaining 24 patients (26%) were referred for evaluation of HCC recurrence but did not have prior PET. The FDG images were acquired with two dedicated PET tomographs [Siemens ECAT 933, CTI (Knoxville, TN) and GE Advance, General Electric Medical Systems (Milwaukee, WI)] one hour after the ...
BACKGROUND: Positron emission tomography combined with computed tomography (PET-CT) is increasingly being used in the staging of oesophageal cancer. Some recent reports suggest it may be used to predict survival. None of these studies, however, reported on the prognostic value of PET-CT performed before neoadjuvant chemotherapy and surgery. The aim of this study was to determine whether pretreatment PET-CT could predict survival. METHODS: Consecutive patients with oesophageal adenocarcinoma who underwent PET-CT before neoadjuvant chemotherapy and resection were included. Maximum standardized uptake value (SUV(max)), fluorodeoxyglucose (FDG)-avid tumour length and the presence of FDG-avid local lymph nodes were determined for all patients. Kaplan-Meier survival analysis was performed and multivariable analysis used to identify independent prognostic factors. RESULTS: A total of 121 patients were included (mean age 63 years, 97 men) of whom 103 underwent surgical resection. On an intention-to-treat basis,
PURPOSE To assess the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. METHODS AND MATERIALS Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. RESULTS Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic
Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is a delicate modality for detecting a malignant lesion, increased 18F-FDG uptake is also seen in infected or inflammatory processes. nodes with intense 18F-FDG uptake (maximum SUV of 8.8) are seen in the right axilla (in a and c), which were diagnosed with tuberculous lymphadenitis. Moreover, a lymph node with intense 18F-FDG uptake (optimum SUV of 5.0) sometimes appears in the proper lower paratracheal section of the mediastinum (in a and c) Subsequently, she underwent best mastectomy with best axillary lymph node dissection. Histopathological study of the right breasts lesion demonstrated invasive ductal breasts carcinoma without lymphatic or vascular invasion. All 36 dissected lymph nodes demonstrated granulomatous lymphadenitis with caseation necrosis no involvement of malignancy. Special spots for acid-fast bacilli had been detrimental for the axillary lymph nodes; nevertheless, polymerase chain response (PCR) ...
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Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been recommended as a complementary tool for the staging of various malignancies, including malignant lymphoma. PET...
Background/Purpose: The disease activity score based on 28 joints (DAS-28) might not be sufficient to assess remission in rheumatoid arthritis (RA). Several studies have shown that patients in remission according to DAS-28 still evidence synovitis by Ultrasound (US) and Magnetic Resonance Imaging (MRI). Those patients could eventually develop irreversible joint damage. Although 18F-Fluorodeoxyglucose Positron Emission Computer Tomography (18F-FDG PET/CT) is known to be correlated with DAS-28 in patients with active RA, its role in assessing remission has not yet been evaluated.. Methods: A cross-sectional study was performed on 63 RA patients. A total of 1764 joints was assessed. Clinical assessment (DAS-28), 18F-FDG PET/CT and US were performed the same day. Patients were classified in 3 groups according to their disease status : 22 (35%) were in remission (DAS-28 , 2.6), 31 (49%) had a low or moderate disease activity (2.6 , DAS-28 ≤ 5.1) and 10 (16%) had a severe disease activity (DAS 28 , ...
Video articles in JoVE about positron emission tomography include Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images, Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG, A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space, Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT), Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models, The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies, Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking, Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by
Purpose: To investigate the prognostic role of metabolic response by the use of serial sets of positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer who were treated with concurrent chemoradiation therapy (CCRT). Methods and Materials: A total of 60 patients who were treated with CCRT between February 2009 and December 2010 were analyzed. Three sequential PET/CT images were acquired for each patient: pre-CCRT, during-CCRT at 4 weeks of CCRT, and 1 month post-CCRT PET/CT. Metabolic responses were assessed qualitatively. The percentage changes in the maximum values of standardized uptake value (ΔSUV{sub max}%) from the PET/CT images acquired pre-CCRT and during-CCRT were calculated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate whether ΔSUV{sub max}% could predict complete response (CR) on the post-CCRT PET/CT and to identify the best cutoff value. Prognostic factors of progression-free survival (PFS) were analyzed. Results: ...
Ahmad Mirza, MD, Ian Welch, Simon Galloway. The University Hospital of South Manchester, Manchester, United Kingdon. INTRODUCTION: The staging laparoscopy has been used in management of gastrointestinal cancers. The aim of this study was to evaluate the role of staging laparoscopy, in comparison with computed tomography (CT) and Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in staging patients with gastroesophageal junction (GOJ) and gastric cancer.. METHODS: The data were collected for patients between 1996 and 2013 for patients undergoing investigation and treatment for GOJ and gastric cancer at a single institute. The pre-operative data (staging data), intra-operative details, post-operative course and outpatient follow-up were analysed for individual cases.. RESULTS: Staging laparoscopy altered management plan in 54 (14%) of 387 patients. Patients with negative staging CT scan and negative FDG-PET, 7% (Type I, II and III GOJ) were identified with pathological ...
Positron Emission Tomography Scanners Market: Global Demand, Growth Analysis & Opportunity Outlook 2023. The global positron emission tomography scanners market is segmented into applications such as oncology, cardiology and neurology. Among these segments, with 85% market share in overall positron emission tomography scanners market, oncology occupied the biggest share in terms of revenue in 2015 and it is expected to garner at a notable CAGR of 4.3% during the forecast period. Further, the growth of this segment is attributed to increasing number of population affected with cancer. Moreover, favorable government initiates along with adoption of technological advanced devices to diagnose and determine the severity of diseases such as cancer and others is also believed to foster the growth of positron emission tomography scanners market. Global positron emission tomography scanners market is anticipated to account for a notable CAGR of 5.2% over the forecast period i.e. 2015-2023. Moreover, the ...
Positron Emission Tomography Scanners Market: Global Demand, Growth Analysis & Opportunity Outlook 2023. The global positron emission tomography scanners market is segmented into applications such as oncology, cardiology and neurology. Among these segments, with 85% market share in overall positron emission tomography scanners market, oncology occupied the biggest share in terms of revenue in 2015 and it is expected to garner at a notable CAGR of 4.3% during the forecast period. Further, the growth of this segment is attributed to increasing number of population affected with cancer. Moreover, favorable government initiates along with adoption of technological advanced devices to diagnose and determine the severity of diseases such as cancer and others is also believed to foster the growth of positron emission tomography scanners market. Global positron emission tomography scanners market is anticipated to account for a notable CAGR of 5.2% over the forecast period i.e. 2015-2023. Moreover, the ...
Despite the growing use of [18F]-FDG PET imaging in oncology (9, 10), limited data exist regarding its use in monitoring treatment response and predicting survival in advanced TETs (11, 19-31). With a few exceptions (25, 27, 28, 30), most studies in this area have been retrospective, involving small sample sizes and inconsistent measures of [18F]-FDG uptake. Furthermore, the majority of the studies have an overrepresentation of thymoma compared with thymic carcinoma. There is limited information on its role in monitoring treatment response and as a predictor of survival (20, 23), and we are not aware of prospective systematic studies addressing these questions.. As a retrospective analysis of prospectively collected data, this study shows that in patients with advanced or recurrent TETs: (i) effective treatment with chemotherapy or targeted therapy causes rapid reduction in [18F]-FDG uptake, (ii) early metabolic response predicts eventual RECIST response and is associated with improved PFS, and ...
Sigma-Aldrich offers abstracts and full-text articles by [Sung Gwe Ahn, Jong Tae Park, Hak Min Lee, Hak Woo Lee, Tae Joo Jeon, Kyunghwa Han, Seung Ah Lee, Seung Myung Dong, Young Hoon Ryu, Eun Ju Son, Joon Jeong].
The present study, discussed a rare case of a 50‑year‑old woman who was treated for malignant melanoma and underwent 18F‑fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F‑FDG‑PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant. By abdominal ultrasound no abnormalities in abdominal organs beside the liver cyst were found. The 18F‑FDG PET/CT exam showed an increased glucose metabolism in the anterior pole of the spleen, which was considered as melanoma metastasis. Splenectomy was performed and histopathology examination tuberculous lesion in the spleen was revealed. Histopathology examination showed epithelioid granuloma and in correlation with the patients history allowed to establish ...
We audited whether 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) imaging could discriminate between different diagnoses in HIV-infected patients presenting with lymphadenopathy, with or without fever and/or splenomegaly. Maximum standardised uptake (SUVmax) values were similar in lymphoma and mycobacterial and fungal infections and were lower but similar in those with human herpesvirus (HHV) 8-associated disease and HIV-associated reactive lymphadenopathy. Nodal 18FDG avidity, with SUVmax ≥10, excluded diagnoses of HHV 8-associated disease and miscellaneous conditions, and HIV-associated reactive lymphadenopathy was additionally excluded in those who had undetectable plasma HIV viral loads ...
Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37-69%) of recurrences originated inside the FDG-positive ...
INTRODUCTION: The prevalence and detailed biomarkers characteristic of rapidly progressive Alzheimers disease (rpAD) remain incompletely understood.METHODS: A total of 312 mild AD patients from the Alzheimers Disease Neuroimaging Initiative database were chosen and dichotomized into rpAD and non-rpAD groups. We performed the prevalence and comprehensive biomarker evaluation.RESULTS: The prevalence of rpAD was 17.6% in mild AD. Compared with non-rpAD, there were no differences in APOE ε4/ε4, APOE ε3/ε4, and APOE ε2/ε4 genotype distribution, cerebrospinal fluid tau, phosphorylated tau (p-tau), amyloid-β, hippocampus volume, and amyloid deposition in rpAD. Yet, a lower p-tau/tau ratio was observed in rpAD (P = .04). rpAD showed region-specific hypometabolism ([18F]fluorodeoxyglucose-positron emission tomography [FDG-PET]) (P = .001). Receiver-operating characteristic analysis of FDG-PET demonstrated that left angular and left temporal cortices were the regions with higher area under the ...
In Parkinsons disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinsons disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinsons patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinsons Disease Rating Scale (UPDRS III) and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P , 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
BACKGROUND: The purpose of this study was to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and (18)F-fluorodeoxyglucose positron emission tomography computed tomography (FDG-PET/CT) for evaluation of response to chemotherapy and bevacizumab and for prediction of progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) with potentially resectable liver lesions. METHODS: A total of 19 mCRC patients were treated with FOLFOX/FOLFIRI and bevacizumab followed by surgery. Dynamic contrast-enhanced magnetic resonance imaging and FDG-PET/CT were performed before treatment and after cycle 5. PET results were quantified by calculating maximum standardised uptake value (SUV(max)) whereas area under the enhancement curve (AUC), initial AUC (iAUC) and the endothelial transfer constant (K(trans)) were used to quantify DCE-MRI. Pathological analysis of the resection specimen was performed, including measurement of microvessel density (MVD) and ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Positron emission tomography (PET) is a specialized radiology procedure used to examine various body tissues to identify certain conditions. PET may also be used to follow the progress of the treatment of certain conditions. While PET is most commonly used in the fields of neurology, oncology, and cardiology, applications in other fields are currently being studied.. PET is a type of nuclear medicine procedure. This means that a tiny amount of a radioactive substance, called a radionuclide (radiopharmaceutical or radioactive tracer), is used during the procedure to assist in the examination of the tissue under study. Specifically, PET studies evaluate the metabolism of a particular organ or tissue, so that information about the physiology (functionality) and anatomy (structure) of the organ or tissue is evaluated, as well as its biochemical properties. Thus, PET may detect biochemical changes in an organ or tissue that can identify the onset of a disease process before anatomical changes related ...
Purpose. The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance. 18F-FDG PET/CT was a part of the preoperative study protocol. Patients without evidence of extrahepatic malignant disease on 18F-FDG PET/CT who also fulfilled all the other inclusion criteria underwent LT.. Methods. The preoperative 18F-FDG PET/CT examinations of all patients included in the SECA (secondary cancer) study were retrospectively assessed. Maximum, mean and peak standardized uptake values (SUVmax, SUVmean and SUVpeak), tumor to background (T/B) ratio, metabolic tumor volume (MTV) and total ...
Authors: Sally F Barrington, N George Mikhaeel, Lale Kostakoglu, Michel Meignan, Martin Hutchings, Stefan Mueller, Lawrence H Schwartz, Emanuele Zucca, Richard I Fisher, Judith Trotman, Otto S Hoekstra, Rodney J Hicks, Michael J ODoherty, Roland Hustinx, Alberto Biggi, Bruce D Cheson
A study in this months Disease of the Colon and Rectum reports on the impact of 18-fluorodeoxyglucose positron emission tomography-computed tomography on rectal cancer management.. ...
Background The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations and F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography. Methods and Results The study included 53 patients (45 men) with aortic aneurysms, 47 infrarenal (abdominal aortic) and 6 thoracic (thoracic aortic), who had 1 F-18-FDG positron emission tomography/computed tomography. During a 30-month period, more clinical events occurred in patients with increased F-18-FDG uptake on their last examination than in those without (5 of 18 [28%] versus 2 of 35 [6%]; P=0.03). Wall stress and stress/strength index computed by finite element simulations and F-18-FDG uptake were evaluated in a total of 68 examinations. Twenty-five (38%) examinations demonstrated 1 aneurysm wall area of increased F-18-FDG uptake. The mean number of these areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdominal ...
The complexities of cancer, and cachexia induced by cancer, dictate the necessity of studying this disease in the context of its microenvironment as well as in the context of interactions between the tumor and the body, i.e., the macroenvironment. In the present study, we are applying molecular and functional imaging to understand cancer cachexia and develop clinically translatable indices for early detection of this condition. As models, we are using cachectic (MAC16) and non-cachectic (MAC13) murine colon adenocarcinoma cells. MAC16 tumors induce extensive weight loss in tumor-bearing animals, whereas MAC13 tumors, although histologically similar, do not induce weight loss. By using in vivo 1H MRSI, we detected a high level of total choline in cachectic tumors compared to non-cachectic ones but no differences in lactate levels in tumor extracts. We then performed [18F]fluorodeoxyglucose positron emission tomography studies and observed a significant increase in glucose uptake in the ...
F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer. Poisson, Thomas; Deandreis, Désirée; Leboulleux, Sophie; Bidault, François; Bonniaud, Guillaume; Baillot, Sylvain; Aupérin, Anne; Ghuzlan, Abir; Travagli, Jean-Paul; Lumbroso, Jean; Baudin, Eric; Schlumberger, Martin // European Journal of Nuclear Medicine & Molecular Imaging;Dec2010, Vol. 37 Issue 12, p2277 Purpose: Our aim was to evaluate in anaplastic thyroid carcinoma (ATC) patients the value of F-FDG PET/CT compared with total body computed tomography (CT) using intravenous contrast material for initial staging, prognostic assessment, therapeutic monitoring and follow-up. Methods: Twenty... ...
BACKGROUND: This study investigates whether a histone deacetylase subtype 6 (HDAC6) inhibitor could be used in the treatment of solid tumours.. METHODS: We evaluated the effect of a novel inhibitor, C1A, on HDAC6 biochemical activity and cell growth. We further examined potential of early noninvasive imaging of cell proliferation by [(18)F]fluorothymidine positron emission tomography ([(18)F]FLT-PET) to detect therapy response.. RESULTS: C1A induced sustained acetylation of HDAC6 substrates, α-tubulin and HSP90, compared with current clinically approved HDAC inhibitor SAHA. C1A induced apoptosis and inhibited proliferation of a panel of human tumour cell lines from different origins in the low micromolar range. Systemic administration of the drug inhibited the growth of colon tumours in vivo by 78%. The drug showed restricted activity on gene expression with ,0.065% of genes modulated during 24 h of treatment. C1A treatment reduced tumour [(18)F]FLT uptake by 1.7-fold at 48 h, suggesting that ...
Abstract:. Gestational or pregnancy‑associated breast cancer is defined as breast cancer that is diagnosed during pregnancy, in the first post‑partum year or any time during lactation. We report a rare imaging finding of breast cancer seen on fluorodeoxyglucose‑positron emission tomography/computed tomography (FDG PET/CT) study in a 32‑year‑old lactating woman. The FDG PET/CT study demonstrated uptake in the soft tissue lesion noted in the right breast corresponding to the primary lesion and multiple nodes in the bilateral axilla, right supraclavicular and mediastinum. In addition, there was FDG tracer uptake in both the breast parenchyma related to breast feeding. This case illustrates the first case of breast cancer in a lactating woman described in FDG PET/CT.. ...
PURPOSE: To assess prospectively the value of fluor-18-deoxyglucose (FDG) positron emission tomography (PET), in addition to conventional diagnostic methods (CDM), as a staging modality in candidates for resection of colorectal liver metastases. PATIENTS AND METHODS: In 51 patients analyzed for resection of colorectal liver metastases, clinical management decisions were recorded after a complete work-up with CDM. Afterward, FDG-PET scans were performed and any change of clinical management according to FDG-PET results was carefully documented. Discordances between FDG-PET and CDM results were identified and related to the final diagnosis by histopathology, intraoperative findings, and follow-up. RESULTS: In 10 (20%) out of 51 patients, clinical management decisions based on CDM were changed after FDG-PET findings were known. FDG-PET detected unresectable pulmonary (n = 5) and hepatic metastases (n = 1) and ruled out extrahepatic (n = 2) and hepatic disease (n = 2). Due to FDG-PET, eight patients ...
AbstractNo data exist whether statins have robust anti-inflammatory effects of atherosclerotic plaques primarily during the early treatment period or continuously throughout use. This prospective three time point18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) study of the carotid artery assessed anti-inflammatory effects of statin during the early treatment...