TY - JOUR. T1 - A method for the prediction of drug content of poly(lactic-co-glycolic)acid drug carrier nanoparticles obtained by nanoprecipitation. AU - Tóth, Tünde. AU - Kiss, E.. PY - 2019/4/1. Y1 - 2019/4/1. N2 - Poly(lactic-co-glycolic acid) drug loaded nanoparticles are applied successfully to increase the distribution and bioavailability of hydrophobic drug molecules, although the generally low drug content implies a limitation. Poly(lactic-co-glycolic acid) nanoparticles were prepared by nanoprecipitation to encapsulate model drugs, a series of alkyl-hydroxy-benzoate (parabens) from methyl-to octyl with increasing hydrophobicity to address the influence of drug property on the encapsulation. The drug content and encapsulation efficiency were found to be substantially different for the various parabens. The analysis of the miscibility of the polymer with parabens using their solubility parameters could not provide satisfactory explanation for the experimental findings. The treatment of ...
TY - JOUR. T1 - Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes. T2 - An in vitro study. AU - ShaBan, Munirah. AU - Kim, Soon Hee. AU - Idrus, Ruszymah. AU - Khang, Gilson. PY - 2008. Y1 - 2008. N2 - Background. Synthetic- and naturally derived- biodegradable polymers have been widely used to construct scaffolds for cartilage tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) are bioresorbable and biocompatible, rendering them as a promising tool for clinical application. To minimize cells lost during the seeding procedure, we used the natural polymer fibrin to immobilize cells and to provide homogenous cells distribution in PLGA scaffolds. We evaluated in vitro chondrogenesis of rabbit articular chondrocytes in PLGA scaffolds using fibrin as cell transplantation matrix. Methods. PLGA scaffolds were soaked in chondrocytes-fibrin suspension (1 × 106cells/ scaffold) and polymerized by dropping thrombin-calcium chloride (CaCl ...
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Introduction: Treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. Case Report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. The patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. These sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. Conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful substitute for
Introduction Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are widely used as delivery carriers for anticancer drugs. However, the obvious initial burst release phenomenon of PLGA nanoparticles is unfavorable for anticancer drugs that have significant systemic toxicity as the drug release also needs to be well controlled. To overcome these shortcomings, the objective of the present study was to create multilayered bio-polyelectrolyte chitosan (CHI) and alginate (ALG) composite by a layer by layer (LbL) self-assembly process on the surface of doxorubicin (DOX)-PLGA NPs. Materials and Methods. DOX (99.41% purity) was purchased from HuaFeng United Technology CO. Ltd, Beijing, China. PLGA 50:50 (Mw 15-20 kDa) was obtained from the Institute of Medical Instruments (Shandong, China). ALG (200 MPa·s) and CHI (Mw 49 kDa) were purchased from Sigma Aldrich. DOX-PLGA NPs coated with CHI and ALG were prepared by the LbL self-assembly. The influencing factors for multilayer growth and the growth ...
Page contains details about CpG-loaded poly(lactic-co-glycolic acid) nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Global Poly Lactic-Co-Glycolic Acid (PLGA) market is segmented on the basis of product type, application, and geography. Poly Lactic-Co-Glycolic Acid (PLGA) is a single base polymer for controlled release of drugs and medical implant materials. PLGA is both - biocompatible and biodegradable, and while both monomers occur naturally it has minimal toxicity. Poly Lactic-Co-Glycolic Acid (PLGA) is naturally amorphous (not crystalline).. PLGA is a synthetic copolymer of lactic acid and glycolic acid is approved by the FDA (Food and Drug Administration) for drug delivery owing to its drug biocompatibility, biodegradability, suitable biodegradation kinetic and mechanical properties, and ease of processing. In the past few years, Poly Lactic-Co-Glycolic Acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for tissue engineering and drug delivery applications.. Full Research Report On Global PLGA Market Analysis available at: ...
Polyglycolic Acid Suture is a braided synthetic surgical suture composed of 100% glycolide. Features: Easy passage through the tissue Greater tensile strength Absorption time: 30 days for standard polyglycolic acid Thread colour: purple for standard polyglycolic acid 70% to 85% of resistance to traction after 2 weeks (test in vitro) Lifetime: 3 years. Sterile, single use. One box of 12 sutures ...
There are comments on PubPeer for publication: Poly(lactic-co-glycolic acid): Carbon nanofiber composites for myocardial tissue engineering applications (2011)
Description. Polyglycolic Acid (PGA Suture) is an absorbable, sterile, synthetic surgical suture, composed of homopolymers of Glycolide (100%). UNIGLYDE is also available undyed. UNIGLYDE Polyglycolic Acid Suture meets all the requirements as per United States Pharmacopeia for Absorbable Surgical suture (Synthetic ...
Creative Diagnostics provides DiagPoly™ Fluorescent Poly(lactic-co-glycolic acid) PLGA Microspheres, Green, 30 µm, L/G=50/50 for immunoassay, bioseparation and medical imaging applications.
Creative Diagnostics provides DiagPoly™ Fluorescent Poly(lactic-co-glycolic acid) PLGA Microspheres, Green, 125 µm, L/G=50/50 for immunoassay, bioseparation and medical imaging applications.
Multidrug-resistant breast cancers have limited and ineffective clinical treatment options. This study aimed to develop PLGA nanoparticles containing a synergistic combination of vincristine and verapamil to achieve less toxicity and enhanced efficacy on multidrug-resistant breast cancers. The 1:250 molar ratio of VCR/VRP showed strong synergism with the reversal index of approximately 130 in the multidrug-resistant MCF-7/ADR cells compared to drug-sensitive MCF-7 cells. The lyophilized nanoparticles could get dispersed quickly with the similar size distribution, zeta potential and encapsulation efficiency to the pre-lyophilized nanoparticles suspension, and maintain the synergistic in vitro release ratio of drugs. The co-encapsulated nanoparticle formulation had lower toxicity than free vincristine/verapamil combinations according to the acute-toxicity test. Furthermore, the most effective tumor growth inhibition in the MCF-7/ADR human breast tumor xenograft was observed in the co-delivery
Malignant gliomas are aggressive, highly vascularized tumors, which recur within 2 cm of the original tumor core and are rarely metastatic. Studies have shown that endogenous inhibitors, such as endostatin, PF-4, and PEX, inhibit the angiogenic process in glioma tumors leading to tumor growth inhibition (10, 12, 23-25, 28). These studies and others also emphasize the urgent need for modalities that can localize and prolong the administration of the antitumor agents to achieve long-term tumor inhibition. Implantable biodegradable polymeric devices provide a unique practical means of localizing the anticancer agents at the tumor site. The strategy of using a controlled delivery device reduces the amount of protein needed, relative to systemic administration, to achieve similar tumor inhibition. In addition, an efficient delivery of labile proteins with short half-lives may be advantageous when using such systems. To date, the efficacy of different control delivery devices for brain tumor therapy ...
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A method for the production of polyglycolic acid polymer useful in the manufacture of sutures, meshes, gauzes, molded clips and like medical articles.
The effects of double release of insulin-like growth factor I (IGF-I) and growth factor β1 (TGF-β1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were studied on PLGA scaffolds. The release was achieved by using nanoparticles of poly(lactic acid-co-glycolic acid) (PLGA) and poly(N-isopropylacrylamide) (PNIPAM) carrying IGF-I and TGF-β1, respectively. On tissue culture polystyrene (TCPS), TGF-β1 released from PNIPAM nanoparticles was found to have a significant effect on proliferation, while IGF-I encouraged differentiation, as shown by collagen type II deposition. The study was then conducted on macroporous (pore size 200-400μm) PLGA scaffolds. It was observed that the combination of IGF-I and TGF-β1 yielded better results in terms of collagen type II and aggrecan expression than GF-free and single GF-containing applications. It thus appears that gradual release of a combination of growth factors from nanoparticles ...
Page contains details about poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The dual extrusion electrospinning technique was used to fabricate multilayered 3D scaffolds by stacking microfibrous meshes of poly(lactic acid-co-glycolic acid) (PLGA) in alternate fashion to micro/nano mixed fibrous meshes of PLGA and collagen. To fabricate the multilayered scaffold, 35 wt% solution of PLGA in THF-DMF binary solvent (3:1) and 5 wt% solution of collagen in hexafluoroisopropanol (HFIP) with and without hydroxyapatite nanorods (nHA) were used. The dual and individual electrospinning of PLGA and collagen were carried out at flow rates of 1.0 and 0.5 mL/h, respectively, at an applied voltage of 20 kV. The density of collagen fibers in multilayered scaffolds has controlled the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. The homogeneous dispersion of glutamic acid-modified hydroxyapatite nanorods (nHA-GA) in collagen solution has improved the osteogenic properties of fabricated multilayered scaffolds. The fabricated multilayered scaffolds were characterized
Development of vaccines in autoimmune diseases has received wide attention over the last decade. However, many vaccines showed limited clinical efficacy. To enhance vaccine efficacy in infectious diseases, biocompatible and biodegradable polymeric nanoparticles have gained interest as antigen delivery systems. We investigated in mice whether antigen-encapsulated PLGA (poly-lactic-co-glycolic acid), PLGA-TMC (N-trimethyl chitosan) or TMC-TPP (tri-polyphosphate) nanoparticles can also be used to modulate the immunological outcome after nasal vaccination. These three nanoparticles enhanced the antigen presentation by dendritic cells, as shown by increased in vitro and in vivo CD4(+) T-cell proliferation. However, only nasal PLGA nanoparticles were found to induce an immunoregulatory response as shown by enhanced Foxp3 expression in the nasopharynx associated lymphoid tissue and cervical lymph nodes. Nasal administration of OVA-containing PLGA particle resulted in functional suppression of an ...
Introduction: Prostate cancer remains the leading cause of cancer-related mortality in men with an estimated 241,740 new cases and 28,170 deaths expected by end of 2012. Conventional cancer treatments such as radiation therapy can be ineffective due to radiation resistance of prostate cancer cells. This resistance arises due to their increased DNA double strand break (DSB) repair ability, especially through Non-Homologous End Joining (NHEJ). In this study, we have developed biodegradable and biocompatible poly lactic-co-glycolic acid (PLGA)-based nanoparticles containing the potent radio-sensitizer NU7441 (8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one) for radiation sensitization of prostate cancer cells by inhibiting DNA-dependent protein kinase, which regulates NHEJ.. Methods: PLGA nanoparticles encapsulating NU7441 and iron oxide as an imaging and targeting agent were prepared by a standard double emulsion technique and characterized for size and surface charge. R11 peptide was ...
The outcome of scaffold-based stem cell transplantation remains unsatisfied due to the poor survival of transplanted cells. One of the major hurdles associated with the stem cell survival is the immune rejection, which can be effectively reduced by the use of immunosuppressant. However, ideal localized and sustained release of immunosuppressant is difficult to be realized, because it is arduous to hold the drug delivery system within scaffold for a long period of time. In the present study, the sustained release of immunosuppressant for the purpose of improving the survival of stem cells was successfully realized by a nanoparticle-anchoring hydrogel scaffold we developed. Methods: Poly (lactic-co-glycolic acid) (PLGA) nanoparticles were modified with RADA16 (RNPs), a self-assembling peptide, and then anchored to a RADA16 hydrogel (RNPs + Gel). The immobilization of RNPs in hydrogel was measured in vitro and in vivo, including the Brownian motion and cumulative leakage of RNPs and the in vivo ...
Synthetic biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) has been fabricated into thin films for use as scaffolds for cell transplantation and guided tissue regeneration. We evaluated the ability of PLGA films to ...
Sepsis is the most frequent cause of death in hospitalized patients, and severe sepsis is a leading contributory factor to acute respiratory distress syndrome (ARDS). At present, there is no effective treatment for these conditions, and care is primarily supportive. Murine sialic acid-binding immunoglobulin-like lectin-E (Siglec-E) and its human orthologs Siglec-7 and Siglec-9 are immunomodulatory receptors found predominantly on hematopoietic cells. These receptors are important negative regulators of acute inflammatory responses and are potential targets for the treatment of sepsis and ARDS. We describe a Siglec-targeting platform consisting of poly(lactic-co-glycolic acid) nanoparticles decorated with a natural Siglec ligand, di(α2→8) N-acetylneuraminic acid (α2,8 NANA-NP). This nanoparticle induced enhanced oligomerization of the murine Siglec-E receptor on the surface of macrophages, unlike the free α2,8 NANA ligand. Furthermore, treatment of murine macrophages with these nanoparticles ...
Background Poly(lactic-co-glycolic acid) (PLGA)-based microparticles offer a great potential as parenteral controlled drug delivery systems [1]. Dif
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Fifty-two years after the FDA approved the first corticosteroid named Kenalog for use in humans, the agency has finally approved an extended-release version of the treatment.. Game Changer. On October 6, 2017, Flexion Therapeutics Inc. announced FDA approval of Zilretta, the "first and only extended-release, intra-articular injection for osteoarthritis knee pain." One Wall Street analyst called it a "monumental milestone" for the company. In a previous story in OTW we wrote that we believed FDA approval would be a game changer.. The product, according to the company, is a non-opioid medicine that uses the companys proprietary microsphere technology combining triamcinolone acetonide (TCA)-a commonly administered, short-acting corticosteroid-with a poly lactic-co-glycolic acid (PLGA) matrix to provide extended pain relief over 12 weeks.. And it was about time. For those 52 years TCA has been used as an anti-inflammatory treatment for ocular and skin problems.. Data. Back in December 2016, Flexion ...
The limitations in the transport of oxygen, nutrients, and metabolic waste products pose a challenge to the development of bioengineered bone of clinically relevant size. This paper reports the design and characterization of hierarchical macro/microporous scaffolds made of poly(lactic-co-glycolic) acid and nanohydroxyapatite (PLGA/nHA). These scaffolds were produced by combining additive manufacturing (AM) and thermally induced phase separation (TIPS) techniques. Macrochannels with diameters of ∼300 μm, ∼380 μm, and ∼460 μm were generated by embedding porous 3D-plotted polyethylene glycol (PEG) inside PLGA/nHA/1,4-dioxane or PLGA/1,4-dioxane solutions, followed by PEG extraction using deionized (DI) water. We have used an I-optimal design of experiments…. ...
The limitations in the transport of oxygen, nutrients, and metabolic waste products pose a challenge to the development of bioengineered bone of clinically relevant size. This paper reports the design and characterization of hierarchical macro/microporous scaffolds made of poly(lactic-co-glycolic) acid and nanohydroxyapatite (PLGA/nHA). These scaffolds were produced by combining additive manufacturing (AM) and thermally induced phase separation (TIPS) techniques. Macrochannels with diameters of ∼300 μm, ∼380 μm, and ∼460 μm were generated by embedding porous 3D-plotted polyethylene glycol (PEG) inside PLGA/nHA/1,4-dioxane or PLGA/1,4-dioxane solutions, followed by PEG extraction using deionized (DI) water. We have used an I-optimal design of experiments…. ...
The incorporation of lomustine, a hydrophobic anticancer drug into PLGA nanoparticles by interfacial deposition method was optimized. Based on the optimal parameters, it ..
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies.
Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model Fabio R. Formiga, Beatriz Pelacho, Elisa Garbayo, Gloria Abizanda, Juan J. Gavira, Teresa Simon-Yarza, Manuel Mazo, Esther Tamayo, Carlos Jauquicoa, Carlos Ortiz-de-Solorzano, Felipe Prosper, Maria J. Blanco-Prieto Journal of Controlled Release Article in Press, Accepted Manuscript doi:10.1016/j.jconrel.2010.07.097…
Objective(s): Encapsulated pharmaceuticals are presently the object of comprehensive investigations in many research centers due to their increased therapeutic efficiency, bioavailability, and high dissolution rate. There are different procedures for encapsulation and choice of procedure influences the size of particles for intended applications. Methods: In this study, Nanocapsules of Poly-Lactic-co-Glycolic Acid (PLGA) containing Bovine Serum Albumin (BSA) at ratios of 0.25/0.25, 0.4/0.1 and 0.45/0.05 were fabricated by electrospraying method. Also, the effect of some parameters in electrospraying was evaluated, including PLGA concentration, voltage and flow rate on the morphology and size of particles. Results: BSA loaded PLGA Nanocapsules were successfully prepared by using electrospraying technique. The formation of capsules was confirmed by TEM. SEM results of the samples showed that decreasing the flow rate and increasing voltage decreased the average size of nanocapsules and led to producing
Controlled release systems for therapeutic molecules are vital to allow the sustained local delivery of their activities which direct cell behaviour and enable novel regenerative strategies. Direct programming of cells using exogenously delivered transcription factors can by-pass growth factor signalling but there is still a requirement to deliver such activity spatio-temporally. We previously developed a technology termed GAG-binding enhanced transduction (GET) to efficiently deliver a variety of cargoes intracellularly, using GAG-binding domains which promote cell targeting, and cell penetrating peptides (CPPs) which allow cell entry. Herein we demonstrate that GET system can be used in controlled release systems to mediate sustained intracellular transduction over one week. We assessed the stability and activity of GET peptides in poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles (MPs) prepared using a S/O/W double emulsion method. Efficient encapsulation (∼65%) and tailored ...
Long-term drug delivery has advantages over traditional drug delivery, including better patient compliance, increased effectiveness of drugs and reduction of side effects. A promising way to achieve long-term controlled drug delivery is to use drug-loaded biodegradable polymeric nanoparticles. A specific problem in using nanoparticles for controlled drug delivery is to control the duration of action and the rate and amount of drug released at any time. We have addressed this problem by using a system of a model hydrophobic drug, haloperidol encapsulated in a biodegradable polymer, poly(lactide-co-glycolide acid) (PLGA). We have developed emulsion-solvent evaporation methods for producing haloperidol-loaded PLGA nanoparticles with up to 2.5% (wt/wt. of polymer) drug content, in-vitro release duration of 13-40 days and less than 20% burst release. The free haloperidol is removed from the nanoparticle suspension using a novel solid phase extraction technique. The size of nanoparticles was effectively
From last decade, researchers have synthesized PLGA poly (lactic-co-glycolic) acid nanoparticles using solvent displacement, emulsification-solvent evaporation, and nano precipitation methods for various applications summarized in Table 1. Apart from traditional solvent evaporation method some of research groups have used shearing based technologies such as high pressure homogenization, ultra-sonication. From last few years, PLGA with other polymeric nanoparticles were synthesized for various applications. To put in site on PLGA based bi-polymer nanoparticle synthesis, Rescignano N et al. [4] studied synthesis of poly (DL-Lactide-co-Glycolide) copolymer based bi-polymer nanoparticles. The research group adopted a double emulsion (water/oil/water) method and compared the effect of alginate, chitosan and nanostructured cellulose crystals as natural emulsion stabilizers on the morphological, thermal, chemical, and rheological properties of the synthesized nanoparticles [4]. The author reported that ...
Introduction & Objective: Complication of cesarean incision such as infection and disruption can involve the life quality of the patients and also can lead to recurrent physician visit, usually re-hospitalization and re-operation. This study designed to compare the wound disruption between three methods: closure of subcutaneous with polyglycolic , plain and ...
The biodegradable Polymer contains Poly-lactic-co-glycolic acid (PLGA) which will degrade 100% into carbon dioxide and water.. Rapamycin Eluting Coronary Stent Implantation System does not need any other auxiliary polymer like parylene C.. The controlled polymer degradation and release of Rapamycin is designed to terminate simultaneously and is completed within less than three months. This covers exactly the time where the drug is needed at most and is tailored uniquely to various immune response reactions occurring after stent implantation. This is understood as Rapasorb™ - Technology.. ...
|span style=font-weight: bold;>Objective: |/span>|br>There are limited treatments for women with uterine factor infertility. Although uterine transplants have been proposed, they have been unsuccessful and require immunosuppression. An alternative approach is to bioengineer uterine tissue using autologous cells seeded on an absorbable matrix that integrates and repairs uterine defects of multiple sizes and shapes. |br>|span style=font-weight: bold;>Methods: |/span>|br>To investigate the feasibility of this approach, rabbit endometrial and myometrial cells were isolated from a uterine biopsy, labeled with lenti-GFP and then seeded on the interior or exterior surface (respectively) of co-polymer of polyglycolic acid with poly (lactide-co-glycolide) biodegradable scaffolds. Twenty-five rabbits received the autologous cell-seeded constructs for one partially removed uterine horn; whereas 6 rabbits received un-seeded constructs. |br>|span style=font-weight: bold;>Results: |/span>|br>Over six months,
Hamishehkar, Hamed, Emami, Jaber, Najafabadi, Abdolhossien Rouholamini, Gilani, Kambiz, Minaiyan, Mohsen, Mahdavi, Hamid and Nokhodchi, Ali (2010) Effect of carrier morphology and surface characteristics on the development of respirable PLGA microcapsules for sustained-release pulmonary delivery of insulin. International Journal of Pharmaceutics, 389 (1-2). pp. 74-85. ISSN 0378-5173 (doi:10.1016/j.ijpharm.2010.01.021) Mahdavi, Hamid, Mirzadeh, Hamid, Hamishehkar, Hamed, Jamshidi, Ahmad, Fakhari, Amir, Emami, Jaber, Najafabadi, Abdolhossien Rouholamini, Gilani, Kambiz, Minaiyan, Mohsen, Najafi, Mahnaz, Tajarod, Maryam and Nokhodchi, Ali (2010) The effect of process parameters on the size and morphology of poly(D,L-lactide-co-glycolide) micro/nanoparticles prepared by an oil in oil emulsion/solvent evaporation technique. Journal of Applied Polymer Science, 116 (1). pp. 528-534. ISSN 0021-8995 (doi:10.1002/app.31595) Hamishehkar, Hamed, Emami, Jaber, Najafabadi, Abdolhossien Rouholamini, Gilani, ...
Stimulation of a patients immune system to fight cancer is the underlying mechanism of immunotherapy. Cancer immunotherapy manipulates the dendritic cells (DCs) to identify the non-self present in the immunosuppressive microenvironment. This vaccination strategy based on nanoparticulate drug delivery system has the potential to treat cancer through packaging of therapeutic cargoes and delivering them to target immune cells (DCs). FDA approved poly-(D, L-lactic-co-glycolide) is approved for use in human due to its widely accepted properties such as low immunogenicity, minimal toxicity, biocompatibility and biodegradability. The goal of this project is to develop an understanding of a comprehensive relationship between nanoparticle (NP) structure and activity; and address the important requirements of NP structure and chemistry to selectively target specific markers. Plain NPs were prepared by emulsification solvent evaporation method with number of preparation variables. Double emulsification ...
(A-C) In vivo antitumor efficiency of Taxotere and docetaxel-loaded poly(lactic-co-glycolic acid) (PLGA) and poly(lactide)-D-α-tocopheryl polyethylene glycol
Poly(lactic-co-glycolic acid) (PLGA) based nano/micro particles were investigated as a potential vaccine platform for pertussis antigen. Presentation of pertussis toxoid as nano/micro particles (NP/MP) gave similar antigen-specific IgG responses in …. ...
Sigma-Aldrich offers abstracts and full-text articles by [Sima Rahimian, Marieke F Fransen, Jan Willem Kleinovink, Maryam Amidi, Ferry Ossendorp, Wim E Hennink].
Andrew C McUsic, Deepak A Lamba... Thomas A Reh "Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds." Biomaterials 33:5 1396-405 ...
This convenient 1-hole electric waterer bowl for livestock prevents water from freezing in cold-weather environments. Featuring a double-walled molde...
Plaga (Spanish for Plague), known collectively as Las Plagas (Spanish for The Pests), was a parasitic organism believed to be centuries old that was indigenous to an isolated rural mountain region in
The poly(orthoester) (POE)-poly(D,L-lactide-co-glycolide) (50:50) (PLGA) double-walled microspheres with 50% POE in weight were loaded with hydrophilic bovine serum albumin (BSA) and hydrophobic cyclosporin A (CyA). Most of the BSA and CyA was entrapped within the shell and core, respectively, because of the difference in their hydrophilicity. The morphologies and release mechanisms of proteins-loaded double-walled POE/PLGA microspheres were investigated. Scanning electron microscope studies revealed that the CyA-BSA-loaded double-walled POE/PLGA microspheres yielded a more porous surface and PLGA shell than those without BSA. The neat POE and PLGA yielded slow and incomplete CyA and BSA release. In contrast, nearly complete BSA and more than 95% CyA were released in a sustained manner from the double-walled POE/PLGA microspheres. Both the BSA- and CyA-BSA-loaded POE/PLGA microspheres yielded a sustained BSA release over 5 days. The CyA release pattern of the CyA-loaded double-walled POE/PLGA ...