TY - JOUR. T1 - A method for the prediction of drug content of poly(lactic-co-glycolic)acid drug carrier nanoparticles obtained by nanoprecipitation. AU - Tóth, Tünde. AU - Kiss, E.. PY - 2019/4/1. Y1 - 2019/4/1. N2 - Poly(lactic-co-glycolic acid) drug loaded nanoparticles are applied successfully to increase the distribution and bioavailability of hydrophobic drug molecules, although the generally low drug content implies a limitation. Poly(lactic-co-glycolic acid) nanoparticles were prepared by nanoprecipitation to encapsulate model drugs, a series of alkyl-hydroxy-benzoate (parabens) from methyl-to octyl with increasing hydrophobicity to address the influence of drug property on the encapsulation. The drug content and encapsulation efficiency were found to be substantially different for the various parabens. The analysis of the miscibility of the polymer with parabens using their solubility parameters could not provide satisfactory explanation for the experimental findings. The treatment of ...

TY - JOUR. T1 - Fibrin and poly(lactic-co-glycolic acid) hybrid scaffold promotes early chondrogenesis of articular chondrocytes. T2 - An in vitro study. AU - ShaBan, Munirah. AU - Kim, Soon Hee. AU - Idrus, Ruszymah. AU - Khang, Gilson. PY - 2008. Y1 - 2008. N2 - Background. Synthetic- and naturally derived- biodegradable polymers have been widely used to construct scaffolds for cartilage tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) are bioresorbable and biocompatible, rendering them as a promising tool for clinical application. To minimize cells lost during the seeding procedure, we used the natural polymer fibrin to immobilize cells and to provide homogenous cells distribution in PLGA scaffolds. We evaluated in vitro chondrogenesis of rabbit articular chondrocytes in PLGA scaffolds using fibrin as cell transplantation matrix. Methods. PLGA scaffolds were soaked in chondrocytes-fibrin suspension (1 × 106cells/ scaffold) and polymerized by dropping thrombin-calcium chloride (CaCl ...

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DataIntelo, the fastest growing market research company, has published a report on the Poly(Lactic-Co-Glycolic Acid) (PLGA) market. This market report provides a holistic scope of the market which includes future supply and demand scenarios, changing market trends, high growth opportunities, and in-depth analysis of the future market prospects. The report covers the competitive data analysis of the emerging and prominent players of the market. Along with this, it provides comprehensive data analysis on the risk factors, challenges, and possible new market avenues.. The report has been prepared with the help of a robust research methodology to cover the market in a detailed manner. To publish a top-notch Global Poly(Lactic-Co-Glycolic Acid) (PLGA) Market report, the market report has undergone extensive primary and secondary research. The dedicated research team conducted interviews with the delegated industry experts to lay out a complete overview of the market. This market research report ...

Introduction: Treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. Case Report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. The patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. These sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. Conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful substitute for

A research article compiles a thorough figurative study of the Global Polyglycolic Acid Suture Market particularly targeting the current global market size and volume, growth prospects, and opportunities. The study entails key data with respect to the forecast study and representation of market estimates. It also imparts a detailed primary and secondary market analysis thoroughly understanding the Polyglycolic Acid Suture market dynamics coupled with the current trends and the major influential factors. The main objective of the market study is to identify the key points of strengths and weaknesses enabling troubleshooting the current challenges and understanding the probable Polyglycolic Acid Suture market growth by encountering the hindrances.. Request a sample of Polyglycolic Acid Suture Market report @ https://marketresearchinc.com/request-sample.php?id=9704#utm_source=Aniket&utm_medium=July2021 A qualitative market analysis supported by factual data represents the exact drivers and ...

Introduction Poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) are widely used as delivery carriers for anticancer drugs. However, the obvious initial burst release phenomenon of PLGA nanoparticles is unfavorable for anticancer drugs that have significant systemic toxicity as the drug release also needs to be well controlled. To overcome these shortcomings, the objective of the present study was to create multilayered bio-polyelectrolyte chitosan (CHI) and alginate (ALG) composite by a layer by layer (LbL) self-assembly process on the surface of doxorubicin (DOX)-PLGA NPs. Materials and Methods. DOX (99.41% purity) was purchased from HuaFeng United Technology CO. Ltd, Beijing, China. PLGA 50:50 (Mw 15-20 kDa) was obtained from the Institute of Medical Instruments (Shandong, China). ALG (200 MPa·s) and CHI (Mw 49 kDa) were purchased from Sigma Aldrich. DOX-PLGA NPs coated with CHI and ALG were prepared by the LbL self-assembly. The influencing factors for multilayer growth and the growth ...

Page contains details about CpG-loaded poly(lactic-co-glycolic acid) nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

The applicative potential of synthetic calcium phosphates, especially hydroxyapatite (HAp), has become intensely broadened in the past 10 years, from bone tissue engineering to multiple other fields of biomedicine. Previously we have shown that hydroxyapatite nanoparticles coated with chitosan-poly(D,L)-lactide-co-glycolide (HAp/Ch-PLGA) target lungs following their intravenous administration into mice. For this purpose radioactive 125-Iodine (125I), a low energy gamma emitter, was used to develop a novel in situ method for radiolabeling of particles and investigation of their biodistribution. In this study we utilize an emulsification process and freeze drying to load the composite particles based on hydroxyapatite nanocarrier, chitosane and poly(lactic-co-glycolic acid) with 17β- hydroxy-17α-picolyl-androst-5-en-3β-acetate (A), a chemotherapeutic derivative of androstane. The picolyl androstane derivatives showed high potency in the cell inhibitors of hormonedependent cancers ...

Global Poly Lactic-Co-Glycolic Acid (PLGA) market is segmented on the basis of product type, application, and geography. Poly Lactic-Co-Glycolic Acid (PLGA) is a single base polymer for controlled release of drugs and medical implant materials. PLGA is both - biocompatible and biodegradable, and while both monomers occur naturally it has minimal toxicity. Poly Lactic-Co-Glycolic Acid (PLGA) is naturally amorphous (not crystalline).. PLGA is a synthetic copolymer of lactic acid and glycolic acid is approved by the FDA (Food and Drug Administration) for drug delivery owing to its drug biocompatibility, biodegradability, suitable biodegradation kinetic and mechanical properties, and ease of processing. In the past few years, Poly Lactic-Co-Glycolic Acid (PLGA) has been among the most attractive polymeric candidates used to fabricate devices for tissue engineering and drug delivery applications.. Full Research Report On Global PLGA Market Analysis available at: ...

Polyglycolic Acid Suture is a braided synthetic surgical suture composed of 100% glycolide. Features: Easy passage through the tissue Greater tensile strength Absorption time: 30 days for standard polyglycolic acid Thread colour: purple for standard polyglycolic acid 70% to 85% of resistance to traction after 2 weeks (test in vitro) Lifetime: 3 years. Sterile, single use. One box of 12 sutures ...

Look forward to your cooperation! Metabolisation of the PGA suture within the tissue occurs by the uptake of water, thus reversing the synthesis. Polyglycolic acid sutures foster the least inflammatory response of absorbable sutures, and the degradation products themselves may be antibacterial. (Similar to Vicryl, Polysorb, Safil) Login to see prices. The chemistry and pharmacology of a new polymer, polyglycolic acid, are described. PGA suture is provided sterile as a single use device. Vicryl. Add to cart More. Price And Quantity. COMPOSITION: CARESYN® is a multifilament, braided, sterile synthetic absorbable surgical suture composed of 100% Polyglycolic Acid, coated with a copolymer of Poly(epsilon-caprolactone) and Calcium stearate. SUTURE CHARACTERISTIC. The suture is available dyed with FDA-approved color additive D&C Violet No. PGA suture have first launched in India by us under the Brand name Petcryl which provided the first Synthetic Absorbable Suture to the Indian market apart from ...

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Anisotropic poly(lactic-co-glycolic acid) microparticles enable sustained release of a peptide for long-term inhibition of ocular neovascularization ...

TY - JOUR. T1 - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres for controlled drug delivery. AU - Park, Kyonghee. AU - Jung, Goo Young. AU - Kim, Myong Ki. AU - Park, Mork Soon. AU - Shin, Yong Kook. AU - Hwang, Jae Kwan. AU - Yuk, Soon Hong. PY - 2012/8. Y1 - 2012/8. N2 - Triptorelin acetate-loaded poly(lactide-co-glycolide) (PLGA) microspheres have been prepared in binary solvent mixtures composed of dichloromethane (DCM) and acetone (AC). The surface morphology of PLGA microspheres was examined by scanning electron microscopy with varying solvent composition, and the size distribution of PLGA microspheres was measured using a particle size analyzer. Triptorelin acetate is a luteinizing hormonereleasing hormone analog that is used as a model peptide drug. With the increase of AC content in the binary solvent mixture, PLGA microspheres with smooth surface were obtained and this led to an increased loading efficiency with the decreased particle size. For the ...

The melting temperatures of all copolymers are lower, and the colors of the copolymers have become lighter than that of PGA homopolymer. While adequate, catgut and the more recently developed regenerated collagens have inherent disadvantages common to many complex natural substances, particularly variability in composition and properties.A new synthetic absorbable suture has been developed from polyglycolic acid .This material was chosen after testing a wide variety of polymers for the appropriate absorbability behavior in animals and for the required physical and mechanical properties. packaging and industrial products applications Polyglycolic Acid (PGA) Resin The Pursuit of Excellence MPa PGA 100 80 60 40 20 0 1 3 5 7 9 11 13 15 17 19 21 23 25 Days Biodegradation (%) Tested by ISO14855 standards PGA Cellulose 1,000 100 10 1 O2TR (cm3/m2â ¢dayâ ¢atm, 30°C, 80%RH) WVTR Researchers have extensively investigated the potential of PLGA nanoparticles for target specific and controlled delivery ...

Name: Absorbable Medical PGA Surgical Suture. PGA also exhibits an elevated degree of crystallinity, around 45-55%, thus resulting in insolubility in water. It has the advantages of high initial tensile strength, smooth passage through tissue, easy handling, excellent knotting ability, and secure knot tying. The absorption time is about 90 days and is made plain or colored violet. Features Polyglycolic acid suture is a synthetic, braided and coated absorbable suture. PGA is a coated, braided, synthetic absorbable surgical suture, composed of Polyglycolic Acid (PGA) and is dyed using FDA-approved colour additives. Model Number: PGA suture. [2] It has also been explored for tissue engineering or controlled drug delivery. During the reaction polyglycolide is formed along with sodium chloride which precipitates within the polymeric matrix; the salt can be conveniently removed by washing the product of the reaction with water. Suture name: P.G.A. [2], Polyglycolide has a glass transition temperature ...

Description. Polyglycolic Acid (PGA Suture) is an absorbable, sterile, synthetic surgical suture, composed of homopolymers of Glycolide (100%). UNIGLYDE is also available undyed. UNIGLYDE Polyglycolic Acid Suture meets all the requirements as per United States Pharmacopeia for Absorbable Surgical suture (Synthetic ...

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Polyglycolic Acid Suture Market Analysis, Size, Trends and Forecast Report. Polyglycolic Acid Suture Market Industry Overview, Market Growth, Syndicate Report and Business Research Reports - UK and US

Creative Diagnostics provides DiagPoly™ Fluorescent Poly(lactic-co-glycolic acid) PLGA Microspheres, Green, 125 µm, L/G=50/50 for immunoassay, bioseparation and medical imaging applications.

Creative Diagnostics provides DiagPoly™ Fluorescent Poly(lactic-co-glycolic acid) PLGA Microspheres, Green, 30 µm, L/G=50/50 for immunoassay, bioseparation and medical imaging applications.

Global Poly- Lactic-Co-Glycolic Acid - PLGA Market Growth 2021-2028 is systematic research that delivers key statistics on the market status of the development trends, competitive landscape analysis, and key regions development status. The report presents an expert and comprehensively analyzes recent key business trends and upcoming Global Poly- Lactic-Co-Glycolic Acid - PLGA market growth outlooks. The report has included strong players and analyzes their limitations and strong points of the well-known players through SWOT analysis. The research report highlights major drivers and constraints, accounts of crucial market participants, splitting analysis, and prediction analysis.. For the competitive landscape analysis, the market report is divided into key companies, by regions, and by various sectors such as application, type. The research document is essential for normal for the key contributors as well as for the brand new entrants inside the marketplace. Moreover, the report has covered ...

Poly(lactic-co-glycolic acid) (PLGA) based nanoparticles have gained increasing attention in delivery applications due to their capability for controlled drug release characteristics, biocompatibility, and tunable mechanical, as well as degradation, properties. However, thorough study is always required while evaluating potential toxicity of the particles from dose dumping, inconsistent release and drug-polymer interactions. In this research, we developed PLGA nanoparticles modified by chitosan (CS), a cationic and pH responsive polysaccharide that bears repetitive amine groups in its backbone. We used a model drug, diclofenac sodium (DS), a nonsteroidal anti-inflammatory drug (NSAID), to study the drug loading and release characteristics. PLGA nanoparticles were synthesized by double-emulsion solvent evaporation technique. The nanoparticles were evaluated based on their particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. About 390-420 nm of average diameters

The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.

Multidrug-resistant breast cancers have limited and ineffective clinical treatment options. This study aimed to develop PLGA nanoparticles containing a synergistic combination of vincristine and verapamil to achieve less toxicity and enhanced efficacy on multidrug-resistant breast cancers. The 1:250 molar ratio of VCR/VRP showed strong synergism with the reversal index of approximately 130 in the multidrug-resistant MCF-7/ADR cells compared to drug-sensitive MCF-7 cells. The lyophilized nanoparticles could get dispersed quickly with the similar size distribution, zeta potential and encapsulation efficiency to the pre-lyophilized nanoparticles suspension, and maintain the synergistic in vitro release ratio of drugs. The co-encapsulated nanoparticle formulation had lower toxicity than free vincristine/verapamil combinations according to the acute-toxicity test. Furthermore, the most effective tumor growth inhibition in the MCF-7/ADR human breast tumor xenograft was observed in the co-delivery

Loses 50% Strength in 14-21 days and is fully absorbed in 60-90 days Uniquely dual-coated for smooth, non-drag suture passage through tissue Violet dyed for greater visibility during placement Braided construction Packaged 12 per box Karl Schumacher PrecísPOINT™ Violet PGA (Polyglycolic Acid) Sutures IFU Package Insert

CARESYN (PGA Sutures) is a multifilament, braided, sterile synthetic absorbable surgical suture composed of 100% Polyglycolic Acid

Malignant gliomas are aggressive, highly vascularized tumors, which recur within 2 cm of the original tumor core and are rarely metastatic. Studies have shown that endogenous inhibitors, such as endostatin, PF-4, and PEX, inhibit the angiogenic process in glioma tumors leading to tumor growth inhibition (10, 12, 23-25, 28). These studies and others also emphasize the urgent need for modalities that can localize and prolong the administration of the antitumor agents to achieve long-term tumor inhibition. Implantable biodegradable polymeric devices provide a unique practical means of localizing the anticancer agents at the tumor site. The strategy of using a controlled delivery device reduces the amount of protein needed, relative to systemic administration, to achieve similar tumor inhibition. In addition, an efficient delivery of labile proteins with short half-lives may be advantageous when using such systems. To date, the efficacy of different control delivery devices for brain tumor therapy ...

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A method for the production of polyglycolic acid polymer useful in the manufacture of sutures, meshes, gauzes, molded clips and like medical articles.

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The effects of double release of insulin-like growth factor I (IGF-I) and growth factor β1 (TGF-β1) from nanoparticles on the growth of bone marrow mesenchymal stem cells and their differentiation into cartilage cells were studied on PLGA scaffolds. The release was achieved by using nanoparticles of poly(lactic acid-co-glycolic acid) (PLGA) and poly(N-isopropylacrylamide) (PNIPAM) carrying IGF-I and TGF-β1, respectively. On tissue culture polystyrene (TCPS), TGF-β1 released from PNIPAM nanoparticles was found to have a significant effect on proliferation, while IGF-I encouraged differentiation, as shown by collagen type II deposition. The study was then conducted on macroporous (pore size 200-400μm) PLGA scaffolds. It was observed that the combination of IGF-I and TGF-β1 yielded better results in terms of collagen type II and aggrecan expression than GF-free and single GF-containing applications. It thus appears that gradual release of a combination of growth factors from nanoparticles ...

Nanoparticle based delivery of anticancer drugs have been widely investigated. However, a very important process for Research & Development in any pharmaceutical industry is scaling nanoparticle formulation techniques so as to produce large batches for preclinical and clinical trials. This process is not only critical but also difficult as it involves various formulation parameters to be modulated all in the same process. In our present study, we formulated curcumin loaded poly (lactic acid-co-glycolic acid) nanoparticles (PLGA-CURC). This improved the bioavailability of curcumin, a potent natural anticancer drug, making it suitable for cancer therapy. Post formulation, we optimized our process by Reponse Surface Methodology (RSM) using Central Composite Design (CCD) and scaled up the formulation process in four stages with final scale-up process yielding 5 g of curcumin loaded nanoparticles within the laboratory setup. The nanoparticles formed after scale-up process were characterized for particle size

Page contains details about poly(lactic-co-glycolic acid)-lecithin-poly(ethylene glycol) core-shell nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

The dual extrusion electrospinning technique was used to fabricate multilayered 3D scaffolds by stacking microfibrous meshes of poly(lactic acid-co-glycolic acid) (PLGA) in alternate fashion to micro/nano mixed fibrous meshes of PLGA and collagen. To fabricate the multilayered scaffold, 35 wt% solution of PLGA in THF-DMF binary solvent (3:1) and 5 wt% solution of collagen in hexafluoroisopropanol (HFIP) with and without hydroxyapatite nanorods (nHA) were used. The dual and individual electrospinning of PLGA and collagen were carried out at flow rates of 1.0 and 0.5 mL/h, respectively, at an applied voltage of 20 kV. The density of collagen fibers in multilayered scaffolds has controlled the adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 cells. The homogeneous dispersion of glutamic acid-modified hydroxyapatite nanorods (nHA-GA) in collagen solution has improved the osteogenic properties of fabricated multilayered scaffolds. The fabricated multilayered scaffolds were characterized

Development of vaccines in autoimmune diseases has received wide attention over the last decade. However, many vaccines showed limited clinical efficacy. To enhance vaccine efficacy in infectious diseases, biocompatible and biodegradable polymeric nanoparticles have gained interest as antigen delivery systems. We investigated in mice whether antigen-encapsulated PLGA (poly-lactic-co-glycolic acid), PLGA-TMC (N-trimethyl chitosan) or TMC-TPP (tri-polyphosphate) nanoparticles can also be used to modulate the immunological outcome after nasal vaccination. These three nanoparticles enhanced the antigen presentation by dendritic cells, as shown by increased in vitro and in vivo CD4(+) T-cell proliferation. However, only nasal PLGA nanoparticles were found to induce an immunoregulatory response as shown by enhanced Foxp3 expression in the nasopharynx associated lymphoid tissue and cervical lymph nodes. Nasal administration of OVA-containing PLGA particle resulted in functional suppression of an ...

Introduction: Prostate cancer remains the leading cause of cancer-related mortality in men with an estimated 241,740 new cases and 28,170 deaths expected by end of 2012. Conventional cancer treatments such as radiation therapy can be ineffective due to radiation resistance of prostate cancer cells. This resistance arises due to their increased DNA double strand break (DSB) repair ability, especially through Non-Homologous End Joining (NHEJ). In this study, we have developed biodegradable and biocompatible poly lactic-co-glycolic acid (PLGA)-based nanoparticles containing the potent radio-sensitizer NU7441 (8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one) for radiation sensitization of prostate cancer cells by inhibiting DNA-dependent protein kinase, which regulates NHEJ.. Methods: PLGA nanoparticles encapsulating NU7441 and iron oxide as an imaging and targeting agent were prepared by a standard double emulsion technique and characterized for size and surface charge. R11 peptide was ...

Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was ...

Historical Overview: Conn began producing a double-walled metal clarinet just a few years after the first saxophone was made in America (1888). Couesnon presented a double-walled Boehm System clarinet in a Paris Exposition in 1900. Triebert also came out with a copy of the Couesnon. Around 1910 Penzel-Mueller (NY) started making the double-walled Clari-Met line to be offered at a price of $150-$200, and was perhaps the most expensive clarinet available at the time. According to the manufacturer, the Clari-Met, made of a special alloy that was almost sterling was destined to make wooden clarinets obsolete. By the mid 1920s there was little interest in the very complicated manufacturing process to produce a clarinet that cost half as much as an automobile. Then in the late 20s Conn began making the Armored clarinet, a double-walled model filled with hard rubber. And finally Haynes started producing a double-walled sterling clarinet which is said to have caused heated debate within the company, ...

The poly(orthoester) (POE)-poly(D,L-lactide-co-glycolide) (50:50) (PLGA) double-walled microspheres with 50% POE in weight were loaded with hydrophilic bovine serum albumin (BSA) and hydrophobic cyclosporin A (CyA). Most of the BSA and CyA was entrapped within the shell and core, respectively, because of the difference in their hydrophilicity. The morphologies and release mechanisms of proteins-loaded double-walled POE/PLGA microspheres were investigated. Scanning electron microscope studies revealed that the CyA-BSA-loaded double-walled POE/PLGA microspheres yielded a more porous surface and PLGA shell than those without BSA. The neat POE and PLGA yielded slow and incomplete CyA and BSA release. In contrast, nearly complete BSA and more than 95% CyA were released in a sustained manner from the double-walled POE/PLGA microspheres. Both the BSA- and CyA-BSA-loaded POE/PLGA microspheres yielded a sustained BSA release over 5 days. The CyA release pattern of the CyA-loaded double-walled POE/PLGA ...

The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration, Poly Vinyl Alcohol (PVA) concentration in the external phase and drug concentration on the particle size was evaluated.

Biodegradable poly(lactic-co-glycolic acid) copolymer, PLGA nanoparticles (NPs) with a surface layer of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, Pluronics, are promising drug carrier systems. With the aim to increase the potential of targeted drug delivery the end group derivative of Pluronics was synthesized in a straightforward way to obtain Pluronic-amines. The formation of functional amine groups was confirmed by fluorescamine method and NMR analysis of their Boc-Phe-OH and Fmoc-Phe-OH conjugates. Pluronic and Pluronic-amine stabilized PLGA NPs prepared by nanoprecipitation were characterized by dynamic light scattering and zeta potential measurements. All of the systems showed high colloidal stability checked by electrolyte induced aggregation, although the presence of Pluronic-amine on the surface decreased the zeta potential in some extent. The introduction of reactive primary amine groups into the surface layer of PLGA NPs while preserving the ...

Cisplatin was encapsulated in 197 nm PLGA nanoparticles with 8.2% drug loading efficiency and 47% encapsulation efficiency. Cisplatin delivery from nanoparticles reaches 80% of total encapsulated drug in 14 days following a triphasic trend. PLGA nanoparticles in MSTO-211H cells were localized in the perinuclear space NP-C in combination with piroxicam induced apoptosis using a final cisplatin concentration 1.75 fold less than free drug. Delivered cisplatin cooperated with piroxicam in modulating cell cycle regulators as caspase-3, p53 and p21.. ...

Title:Kinetic Evaluation of Anti-tumor Chlorambucil Release from O-stearoyl Mannose PLGA Nanoparticles. VOLUME: 10 ISSUE: 1. Author(s):Antonio O. Costa, Claure N. Lunardi and Anderson J. Gomes*. Affiliation:Laboratory of Photochemistry and Nanobiotechnology, University of Brasília, Centro Metropolitano, Conjunto A, lote 01, Brasilia, 72220-275, DF, Laboratory of Photochemistry and Nanobiotechnology, University of Brasília, Centro Metropolitano, Conjunto A, lote 01, Brasilia, 72220-275, DF, Laboratory of Photochemistry and Nanobiotechnology, University of Brasília, Centro Metropolitano, Conjunto A, lote 01, Brasilia, 72220-275, DF. Keywords:PLGA, nanoparticles, o-stearoyl mannose, chlorambucil, mathematical modeling.. Abstract:. Purpose: This study assesses the kinetics of the anti-tumor drug chlorambucil (CLB) incorporated into PLGA nanoparticles (NP-CLB) with and without the presence of the O-stearoyl mannose (OEM) functionalizing agent (NP-CLBMAN). Methods: OEM was synthesized and used in ...

We have investigated the key parameters to fabricate PDLLA (Poly(DL-lactic acid)), PDLLGA (Poly(DL-lactic-co-glycolic acid) 65:35 and blends of PDLLGA 65:35 and PEG (Poly(ethylene glycol)) microspheres containing bovine serum albumin (BSA) as a model protein using the double-emulsion (water-in-oil-in-water) solvent extraction/evaporation method. The release profiles of microspheres were investigated at 22°C in order to develop controlled release devices for marine fishes in tropical area. Various factors that influence the size of microspheres, encapsulation efficiency, initial release, morphology and release profiles of microspheres, and BSA distribution within microspheres have been investigated. These factors include preparation temperature, solvent removal rate, volume ratio of oil phase to internal water phase, and polymer concentration. Microspheres fabricated at a low volume ratio of oil phase to internal water phase and a low polymer concentration tend to have a large surface area, a ...

Stroke causes extensive cellular loss that leads to a disintegration of the afflicted brain tissue. Although transplanted neural stein cells can recover some of the function lost after stroke, recovery is incomplete and restoration of lost tissue is minimal. The challenge therefore is to provide transplanted cells with matrix support in order to optimise their ability to engraft the damaged tissue. We here demonstrate that plasma polymerised allylamine (ppAAm)-treated poly(D,L-lactic acid-co-glycolic acid) (PLGA) scaffold particles can act as a structural support for neural stem cells injected directly through a needle into the lesion cavity using magnetic resonance imaging-derived co-ordinates. Upon implantation, the neuro-scaffolds integrate efficiently within host tissue forming a primitive neural tissue. These neuro-scaffolds could therefore be a more advanced method to enhance brain repair. This study provides a substantial step in the technology development required for the translation of ...

This study trialled the controlled delivery of growth factors within a biodegradable scaffold in a large segmental bone defect model. We hypothesised that co-delivery of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) followed by bone morphogenetic protein-2 (BMP-2) could be more effective in stimulating bone repair than the delivery of BMP-2 alone. Poly(lactic-co-glycolic acid) (PLGA ) based microparticles were used as a delivery system to achieve a controlled release of growth factors within a medical-grade Polycaprolactone (PCL) scaffold. The scaffolds were assessed in a well-established preclinical ovine tibial segmental defect measuring 3 cm. After six months, mechanical properties and bone tissue regeneration were assessed. Mineralised bone bridging of the defect was enhanced in growth factor treated groups. The inclusion of VEGF and PDGF (with BMP-2) had no significant effect on the amount of bone regeneration at the six-month time point in comparison ...

Doxorubicin, a potent anticancer drug associated with cardiotoxicity and low oral bioavailability, was loaded into nanoparticles with a view to improve its performance. Doxorubicin loaded PLGA nanoparticles were prepared by a double emulsion method. The pH dependent stability of nanoparticles in simulated fluids was evaluated. DSC and XRD studies were carried out in order to ascertain the nature of doxorubicin in formulations in conjunction with accelerated stability studies. The in vitro release was investigated in phosphate buffer. The pharmacokinetic and toxicity studies were conducted in rats. Nanoparticles had an average size of 185 nm, with 49% entrapment at 10% w/w of polymer. The particles displayed good pH dependent stability in the pH range 1.1-7.4. DSC and XRD studies revealed the amorphous nature of doxorubicin in nanoparticles and the accelerated stability studies revealed the integrity of formulations. Initial biphasic release (20%) followed by a sustained release (80%) for 24 days ...

Pilocarpine HCI-loaded PLGA nanoparticles were prepared by emulsification solvent evaporation. Three different stabilisers, polyvinylalcohol (PVA), Carbopol and Poloxamer were used, as well as mixtures thereof. The influence of the homogenisation pressure and number of cycles on the properties of nanoparticles were studied. Particle size was shown to depend on the stabiliser used. An increase of the homogenisation pressure or the number of cycles resulted in a decrease in particle size. The zeta potential value was influenced mainly by the nature of the stabiliser. Particles stabilised with poloxamer or PVA showed a slightly negative zeta potential value, while samples stabilised with carbopol posessed a more negative zeta potential, which became less negative after homogenisation. Drug encapsulation depended strongly on the stabiliser used. The higher drug entrapment of the carbopol-stabilised particles could be explained by an electrostatic interaction between the negatively charged carboxyl ...

Many prostate cancers relapse after initial chemotherapy treatment. Combining molecular and chemotherapy together with encapsulation of drugs in nanocarriers provides effective drug delivery and toxicity reduction. We developed core shell lipid-polymer hybrid nanoparticles (CSLPHNPs) with poly (lactic-co-glycolic acid) (PLGA) core and lipid layer containing docetaxel and clinically used inhibitor of sphingosine kinase 1 (SK1) FTY720 (fingolimod). We show for the first time that FTY720 (both free and in CSLPHNPs) re-sensitizes castrate resistant prostate cancer cells and tumors to docetaxel, allowing a four-fold reduction in effective dose. Our CSLPHNPs showed high serum stability and a long shelf life. CSLPHNPs demonstrated a steady uptake by tumor cells, sustained intracellular drug release and in vitro efficacy superior to free therapies. In a mouse model of human prostate cancer, CSLPHNPs showed excellent tumor targeting and significantly lower side effects compared to free drugs, importantly,

PHARMACOLOGY Nanonetworks as Innovative Platforms for Therapeutic Solubilization and Delivery David Michael Stevens Dissertation under the direction of Professor Eva M. Harth Solubility remains the biggest obstacle in the development of new therapeutics and is the primary cause for clinical failure of promising drugs. The high lipophilicity of many chemotherapeutics and peptides imposes a major challenge for systemic administration and drug efficacy. Recent interest of pharmaceutical companies to apply nanoformulations stems from the interest to improve solubility, specificity, and efficacy for current, off-patent, and shelved drugs rather than creating new therapies. Numerous approaches have been investigated including poly(lactic-co-glycolic acid) (PLGA) formulations, lipid-based micelles, and pegylation of proteins, but these efforts often fall short of expectations due to rapid drug release, the use of non-degradable materials, and accumulation and toxicity in the liver. To overcome these ...

TY - JOUR. T1 - The Influence of Solvent Processing on Polyester Bioabsorable Polymers. AU - Dixon, D. AU - Manson, J. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.. AB - Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in ...

Offer Valid: 1/1/18-3/31/18 Buy 3 Boxes of Perma Sharp® Sutures, Get 1 Box Free! Offers Valid January 1 - March 31, 2018 Promo Code 2545 Redemption Info ©2017 Hu-Friedy Mfg. Co., LLC. All rights reserved. Offer valid in the 50 United States and District of Columbia. Does not apply to school, government, group practice or institution offers. To receive your no charge good(s) please fax a copy of your dealer invoice January 1 - March 31, 2018 indicating the required purchases and your no charge goods selection to 773-868-3560, by email to [email protected], or mail to: 1666 E. Touhy Ave., Des Plaines, IL 60018. *Equal or Lesser Value. Redemption must be postmarked by April 30, 2018 ...

Offer Valid: 1/1/18-3/31/18 Buy 3 Boxes of Perma Sharp® Sutures, Get 1 Box Free! Offers Valid January 1 - March 31, 2018 Promo Code 2545 Redemption Info ©2017 Hu-Friedy Mfg. Co., LLC. All rights reserved. Offer valid in the 50 United States and District of Columbia. Does not apply to school, government, group practice or institution offers. To receive your no charge good(s) please fax a copy of your dealer invoice January 1 - March 31, 2018 indicating the required purchases and your no charge goods selection to 773-868-3560, by email to [email protected], or mail to: 1666 E. Touhy Ave., Des Plaines, IL 60018. *Equal or Lesser Value. Redemption must be postmarked by April 30, 2018 ...

Palladium catalysts have been widely adopted for organic synthesis and diverse industrial applications given their efficacy and safety, yet their biological in vivo use has been limited to date. Here we show that nanoencapsulated palladium is an effective means to target and treat disease through in vivo catalysis. Palladium nanoparticles (Pd-NPs) were created by screening different Pd compounds and then encapsulating bis[tri(2-furyl)phosphine]palladium(II) dichloride in a biocompatible poly(lactic-co-glycolic acid)-b-polyethyleneglycol platform. Using mouse models of cancer, the NPs efficiently accumulated in tumours, where the Pd-NP activated different model prodrugs. Longitudinal studies confirmed that prodrug activation by Pd-NP inhibits tumour growth, extends survival in tumour-bearing mice and mitigates toxicity compared to standard doxorubicin formulations. Thus, here we demonstrate safe and efficacious in vivo catalytic activity of a Pd compound in mammals. Palladium (Pd) is a well-known

Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content Mingguang Li1, Zoi Panagi2, Konstantinos Avgoustakis2, Joshua Reineke11Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA; 2Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion, Patras, GreeceAbstract: Biodistribution of nanoparticles is dependent on their physicochemical properties (such as size, surface charge, and surface hydrophilicity). Clear and systematic understanding of nanoparticle properties' effects on their in vivo performance is of fundamental significance in nanoparticle design, development and optimization for medical applications, and toxicity evaluation. In the present study, a physiologically based pharmacokinetic model was utilized to interpret the effects of nanoparticle properties on previously published biodistribution data. Biodistribution data for five poly

Relatively high molecular weight, fiber-forming, crystalline copolymers of lactide and glycolide are prepared in a two-stage polymerization process. In the first stage there is prepared a random copolymer of a major proportion of an optically active lactide with a minor proportion of glycolide or d,l-lactide. In the second stage, a major amount of glycolide and a minor amount of lactide monomers are admixed with the copolymer of the first stage and the polymerization resumed until there is obtained a high molecular weight addition copolymer of lactide and glycolide containing from about 50 to 75 wt percent of units derived from glycolide. The polymer is fiber-forming and useful in the preparation of absorbable surgical sutures.

1Laboratory of Cancer Drug Therapeutics and Mammalian Cell Technology, Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Haifa, Israel; 2Molecular Mechanisms of Angiogenesis, Universite de Bordeaux I, Talence, France; 3Department of Neurological Sciences, University of Milan, Milan, Italy; and 4Laboratory of Neurosurgical Oncology, Brigham and Womens Hospital, Harvard Medical School, Boston, ...

Robabeh Gharaei of Leeds University (UK) said the materials of the title were being developed as nonwoven scaffolds for tissue engineering. Such scaffolds had to be highly porous 3D structures which were biocompatible, bioresorbable, biodegradable and had an appropriate surface chemistry. Examples given included naturally derived polymers such as collagen, chitosan, and elastin or synthetic polymers such as polycaprolactone, polylactic acid or polyglycolic acid and its copolymers. These could be 3D printed into the appropriate porous structure, spun into nanofibres, or even simply used as a hydrogel. Improvements promoting cell attachment, cell proliferation, cell differentiation and extracellular formation were required, and the incorporation of self-assembling peptides within the polymer was thought to be a potential solution. ...

Examples include variations of polylactic acid (PLA), polyglycolic acid (PGA), polydioxanone, and polycaprolactone. PLA has been a desirable choice because its degradation product is lactic acid, a natural constituent of the Krebs cycle. b. These polymers are resorbed at different rates. i. PLA resorbs faster than PGA. ii. Composite products may have intermediate properties. c. Resorption allows the host tissue to assume its normal role as the load-sharing capabilities of the polymer decrease. This must be balanced with the need for maintaining mechanical properties. Figure 5 The differentiation schema of bone marrow precursor cells into osteoclasts. Cortical cytokine regulators are indicated. M-CSF = macrophage colony-stimulating ligand; RANKL = receptor activator for nuclear factor κB ligand; OPG = osteoprotegerin. 1: Basic Science Figure 4 3. Other intracellular signaling proteins-In addi- tion to secondary messengers, GTP-binding proteins such as Ras and protein kinases can accomplish the ...

A surgical fastener apparatus, for securing a surgical mesh material to body tissue including a pair of anchors each having retaining means formed on an outer surface thereof, and a suture tether interconnecting the pair of anchors to one another. The pair of anchors having a substantially cylindrical body having a conically tapered distal end and a planar proximal end. The retaining means includes a series of semi-circular angled projections having a planar proximal surface and a tapered distal end, wherein a center of each of the angled projections is spaced a distance from a longitudinal central axis of the body portion. The surgical fastener is made from a bioabsorbable material which reabsorbs into said body tissue at an appropriate rate, such as for example, polyglycolic acid and polylactic acid.

A surgical fastener apparatus, for securing a surgical mesh material to body tissue including a pair of anchors each having retaining means formed on an outer surface thereof; and a suture tether interconnecting the pair of anchors to one another. The pair of anchors having a substantially cylindrical body having a conically tapered distal end and a planar proximal end. The retaining means includes a series of semi-circular angled projections having a planar proximal surface and a tapered distal end, wherein a center of each of the angled projections is spaced a distance from a longitudinal central axis of the body portion. The surgical fastener is made from a bioasbsorbable material which reasorbs into said body tissue at an appropriate rate, such as for example, polyglycolic acid and polylactic acid.

Abstract Background and objectives: Non-aggregated protamine impregnated poly(lactide-co-glycolide) nanoparticles of cisplatin (Pt-PLGA NPs) were synthesized to augment brain delivery. Methods and results: The mean particle size of Pt-PLGA NPs and PL

Interestingly, PDA-incorporated NPs showed reduced apoptosis and necrosis reaction in HaCaT cells.39. A possible explanation for the chitosan NPs high biocompatibilty could be that chitosan is much more cytotoxic in a free soluble form than when it is incorporated into NPs, due to the fact that in the case of NPs, a significant portion of the positive amino groups of chitosan are engaged in electrostatic interractions.38, 40. To confirm PLGAChi NPs efficiency in intracellular penetration, the cellular internalization of PLGAChi NPs conjugated with fluorescein was investigated by fluorescence microscopy. The results indicated significant differences in NPs uptake between the different cell lines used in this study.. Fluorescence microscopy experiments conducted after 12h and 24h of incubation revealed a rate of inglobation influenced by the cell type. DPCs did not internalize PLGAChi NPs, even at the highest concentration (200 μg/mL PLGAChi NPs) and the longest incubation time (24h) (Fig. 3). ...

PGA 3/0, No needle (Box of 12) 150cm Thread Length Violet braided Polyglycolic acid. Synthetic, absorbable suture. High tensil strength, predictable absorption rate. Coated with a Co-Polymer of Glycolide, Lactide and Calcium to ensure smooth tissue pass

Choose your poly (D,L-lactic acid)(PLA) and/or poly (D,L-lactic-co-glycolic acid) (PLGA) biodegradable polymers from our wide portfolio to optimize the release kinetics of your final drug products or use our customization capabilities to manufacture the polymer with the characteristics that your need.

Mastering the complexity of PLGA microsphere manufacturing by Daniel Leblanc, Senior Vice President of CMC Operations, Flexion Therapeutics, Inc.

PGA Resorba™ Absorbable Multifilament Suture (Absorbable Sutures) - Overview PGA (polyglycolic acid) Special resolactone coating reduces soft tissue drag Maintains 50 tensile strength for up to 21 days USP 4/0, Violet, HRT18 Needle, 12/box USP 4/0 violet

The ASU Library acknowledges the twenty-two Native Nations that have inhabited this land for centuries. Arizona State Universitys four campuses are located in the Salt River Valley on ancestral territories of Indigenous peoples, including the Akimel Oodham (Pima) and Pee Posh (Maricopa) Indian Communities, whose care and keeping of these lands allows us to be here today. ASU Library acknowledges the sovereignty of these nations and seeks to foster an environment of success and possibility for Native American students and patrons. We are advocates for the incorporation of Indigenous knowledge systems and research methodologies within contemporary library practice. ASU Library welcomes members of the Akimel Oodham and Pee Posh, and all Native nations to the Library.. ...

Objectives: The efficacy of rifampicin-loaded polymeric microspheres (RPLGA) delivered to guinea pigs infected with Mycobacterium tuberculosis (H37Rv) was compared with a daily dose of nebulized rifampicin suspension. Methods: Aerosol-infected animals were subjected to multiple dose or single dose treatment with RPLGA, PLGA microspheres or micronized rifampicin suspension

Proceedings of the International Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Nuremberg, 15-18 March 2004 ...

The RELI® Premium Suture is manufactured for specialty surgeries that requirehigh quality needles. The premium 300 Series Stainless steel Precision Point needle with Redipass® coating make these the ideal suture for the physician performing those specialty surgeries such as Dermatologic, Ophthalmic, Oral and Maxillofacial, Periodontal, Plastic and Reconstructive surgery.. ...

Background: Mitochondria (MITO) injury including MITO permeability transition pore (mPTP) opening plays a major role in the mechanism of ischemia-reperfusion (IR) injury. Intravenous administration of an inhibitor of mPTP opening, cyclosporine A, can reduce IR injury in animals and patients with acute myocardial infarction (MI), however; the power of cardioprotection by cyclosporine A is insufficient. We tested the hypothesis that nanoparticle-mediated targeting of Mdivi1, a chemical inhibitor of Drp1, to MITO enhances cardioprotection from IR injury.. Methods and Results: We formulated poly(lactic acid/glycolic acid) (PLGA) nanoparticles containing Mdivi1 (Mdivi1-NP) or FITC (FITC-NP). In neonatal rat cardiomyocytes, PLGA nanoparticles accumulated in MITO after the addition of hydrogen peroxide (H2O2) that represents oxidative stress during IR (Fig.A). Treatment with Mdivi1-NP reduced H2O2-induced MITO division and cardiomyocyte death (Fig.B). This Mdivi1-NP cardioprotective effect was not seen ...

The originality of the project is the production by means of knitting of a ready-to-use, biocompatible and porous sterilisable carrier material containing two components. This material will be composed of PLGA or poly(lactic-co-glycolic acid) in the substrate (ensuring the medical functionality) and of chitosan as surface layer.. The realisation of this innovating product is a scientific and technical challenge on the crossroad of biotechnology and agrarian resources. The second challenge is the maturation of the product obtained by tissue technology. From the conception till the realisation, we will start from the assumption that it is an operational prototype that is validated under pre-operative circumstances. This is a major step to have the product valorised by the industry.. The research and development action points include the development of the PLGA yarns, the chitosan coating, knitting the textile 3D-matrix and its use for bone reconstruction.. The communication action points that will ...

PLGA is a synthetic biodegradable polymer that can be processed into desirable shape, mechanical properties, and degradation rate. A magnified view of electrospun PLGA scaffold is shown below. PLGA scaffold is coated with collagen that provides cell-recognition signals and hydrophobic properties to facilitate cell growth.

Patients with atherosclerosis experience plaque buildup in the coronary artery, reducing blood flow and increasing the likelihood of a blood clot. Balloon angioplasty and the implantation of a metal stent are physical mechanisms that have been used to treat atherosclerosis and the associated stenosis of the coronary artery with some success; however, restenosis occurs in a substantial amount of patients. Most recently, biodegradable drug eluting stents have been shown to significantly lower restenosis rates, where an implanted stent is coated with biodegradable polymer and an immunosuppressant therapeutic drug; however, many parameters have yet to be optimized in this method of treatment. This project considers a stent coated with the biodegradable polymer poly lactic-coglycolic acid (PLGA) and immunosuppressant sirolimus (also known as rapamycin), for circular and square geometries, and half and full extents of embedment. A mass transport simulation in COMSOL 5.1 Multiphysics was used to ...

Nano- and microcarriers prepared from the biocompatible and biodegradable polymer poly(D,L-lactide-co-glycolide) (PLGA) are being extensively studied for drug-d...

Degradable drug delivery systems composed from polyesters such as PLGA particles are one of the most investigated delivery systems.

This unique double-walled glass carafe is perfect for brewing and service coffee. Designed by the coffee lovers at Fellow Products, this carafe masters both form and function for the ideal pour over experience.

Embosphere Microspheres are the most clinically studied round embolic and provide predictable, proven results for embolisation treatment.

|p||strong|SYIS PODO LINE GÉL NA NOHY S PAGAŠTANOM 500ML|/strong||/p| |p style=text-align: justify;|Chladivý gél na nohy s výťažkom z pagaštanu, kamilky, šalvie a mentolu. Zabraňuje opuchu nôh okol