If you havent heard of this substance, I wouldnt blame you as I hadnt heard of it myself until I ran across the ingredient in a new skincare product I wanted to try. When it comes to skincare and beauty products and ingredients, I do consider myself to be fairly knowledgeable. Ive done quite a bit of research in addition to product testing and reviewing, so when I do find something that I havent even heard of in the world of beauty- Im intrigued ;). Polyglutamic acid or PGA is a polymer of the amino acid glutamic acid; that basically means that a molecule thats repeating over and over until it forms a chain. This chain of molecules is at the cellular level and its composed of glutamic acid- which is a non-essential amino acid that plays a vital role in our bodys nervous system.. As for what polyglutamic acid is used for, there are many various possible uses that range from medicine to water treatment. Cancer patients can receive this as a delivery system for their treatments and there ...

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This report presents studies on the growth conditions necessary for transformation to prototrophy of 14 auxotrophs of B. licheniformis. The unexpected finding of different growth requirements by each auxotroph for the development of transformable cells is discussed. Under optimum growth conditions for a serine-deficient mutant, transformation frequencies of 0.1% were obtained. A defined medium for tube transformation of competent cells is described. In addition, this report presents evidence for the transformation of three non-encapsulated mutants of B. licheniformis for the ability to synthesize polyglutamic acid (capsular material).

pH jumps are a truly biomimetic technique to initiate non-equilibrium dynamics of biomolecules. In this work, the pH jump induced alpha-helix folding of poly-L-glutamic acid is investigated upon proton release from o-nitrobenzaldehyde. The aim of this work is twofold: On the one hand, design criteria of pH jump experiments are discussed, on the other hand, the folding mechanism of poly-L-glutamic acid is clarified by probing the IR response of the amide I band. Its folding kinetics is studied in dependence of the starting pD, the size of the pD jump and the length of the helix. While no dependence on the first two parameters could be detected, the folding time varies from 0.6 mu s to 1.8 mu s for helix lengths of 20 residue to 440 residue, respectively. It converges to a long-length limit at about 50 residue, a result which is attributed to a nucleation-propagation mechanism. ...

Kinetics of compaction on single DNA molecules are studied by fluorescence videomicroscopy in the presence of 1), Xenopus egg extracts and 2), purified nucleosome reconstitution systems using a combination of histones with either the histone chaperone Nucleosome Assembly Protein (NAP-1) or negatively charged macromolecules such as polyglutamic acid and RNA. The comparison shows that the compaction rates can differ by a factor of up to 1000 for the same amount of histones, depending on the system used and on the presence of histone tails, which can be subjected to post-translational modifications. Reactions with purified reconstitution systems follow a slow and sequential mechanism, compatible with the deposition of one (H3-H4)(2) tetramer followed by two (H2A-H2B) dimers. Addition of the histone chaperone NAP-1 increases both the rate of the reaction and the packing ratio of the final product. These stimulatory effects cannot be obtained with polyglutamic acid or RNA, suggesting that yNAP-1 ...

0065]in which: [0066]A independently represents: [0067]an NHR group in which R represents an H, a linear C2 to C10 or branched C3 to C10 alkyl or a benzyl, [0068]a terminal amino acid unit bonded via the nitrogen, the acid functional group(s) of which is (are) optionally modified by an amine or an alcohol corresponding to the definitions NHR and OR respectively; [0069]B is a divalent, trivalent or tetravalent bonding group preferably chosen from the following radicals: [0070]--O--, --NH--, --N--(C1 to C5)alkyl-, an amino acid residue (preferably of a natural amino acid), a diol, a triol, a diamine, a triamine, an aminoalcohol or a hydroxy acid comprising from 1 to 6 carbon atoms; [0071]D represents an H, a linear C2 to C10 or branched C3 to C10 acyl group or a pyroglutamate; [0072]the hydrophobic groups (HGs) each represent, independently of one another, a radical chosen from: [0073]linear or branched C8 to C30 alkyls which can optionally comprise at least one unsaturation and/or at least one ...

Polyglutamic acid (PGA) is a polymer of the amino acid glutamic acid (GA). Gamma PGA has a wide number of potential uses ranging from food and medicine to water treatment.

Page contains details about targeting docetaxel loaded self-assembled poly-gamma-glutamic acid/chitosan nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Page contains details about epirubicin loaded self-assembled poly-gamma-glutamic acid/chitosan nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com

Efficacy of Poly-Gamma-Glutamic Acid in Women with High-Risk Human Papillomavirus-Positive Vaginal Intraepithelial Neoplasia: an Observational Pilot Study;kpubs;kpubs.org

The recovery of low-molecular-weight γ-polyglutamic acid (γ-PGA) by metal ion precipitation from the fermentation broth was explored. The broth containing 20 g/L γ-PGA was firstly adjusted to a low pH (2 or 3) to remove the bacteria cells easily, and then Cu2+ was chosen to recover γ-PGA in the diluted cell-free broth, resulting in the precipitation of a Cu2+-γ-PGA complex. The optimum concentrati ...

1. Dual functions of wrinkle care and whitening: - It solves the skin ageing signs at once. 2. Fresh floral Woody Musk fragrance: - Feeling modern manly beauty and polished style. 3. Synergistic effects of anti-wrinkle effect: - Matrixyl (Peptide ingredient: Wrinkle improvement ability over retinol). 4. Herbal complex extracts give the skin moisture, anti-inflammatory& soothing effects. Herbal fragrance stabilizes the mind and body & has stress easing effect. 5. Contain safe natural food ingredient Polyglutamic acid, it retains its moisture at all times & prevents ageing. Volume: 140ml per qty

1. Dual functions of wrinkle care and whitening: - It solves the skin ageing signs at once. 2. Fresh floral Woody Musk fragrance: - Feeling modern manly beauty and polished style. 3. Synergistic effects of anti-wrinkle effect: - Matrixyl (Peptide ingredient: Wrinkle improvement ability over retinol). 4. Herbal complex extracts give the skin moisture, anti-inflammatory& soothing effects. Herbal fragrance stabilizes the mind and body & has stress easing effect. 5. Contain safe natural food ingredient Polyglutamic acid, it retains its moisture at all times & prevents ageing. Volume: 140ml per qty

Skinfoods Rice Soft Scrub Wash Off Mask is a gentle exfoliating mask that features rice extracts to brighten and soften complexion Organic Black Sugar: Enriched with vitamins and minerals to hydrate and nourish the skin. Rice Extract: Contains proteins, vitamins, and minerals that brighten and nourish your skin to make it radiant. 103 mL / 3.5 oz. Made in Korea.Paraben-free. How to Use: After cleansing, massage gently into damp skin, or mix with water/cosmetic water and apply. Avoid skin around the eyes and lips. After 10-15 minutes, rinse with lukewarm water. Ingredients: Water, Caprylic/Capric Triglyceride, Cyclopentasiloxane, Cetyl Alcohol, Propylene Glycol, Oryza Sativa (Rice) Bran Water, Glycerin, Polysorbate 80, Jojoba Esters, Peg-100 Stearate, Glyceryl Stearate, Palmitic Acid, Stearic Acid, Sorbitan Stearate, Dimethicone, Carbomer, Potassium Hydroxide, Algin, Sucrose Cocoate, Tocopheryl Acetate, Sodium Hyaluronate, Polyglutamic Acid, 1, 2-Hexanediol, Ethylhexylglycerin, Phenoxyethanol, Fragrance

Color pallets. Diversity. Natural. Eco-friendly. Peels. Polyglutamic acid. Masks. Scalp care. What will be the new trend this year? In the hyper-competitive beauty industry, keeping up with the latest trends, while tending to the traditional market, is a daily challenge.. Whether a local favorite or upscale mega-store, technology is key to making informed decisions on where to invest floor space and financial resources. With RMH, data collected on the sales floor generates customized reports that combine with your expertise to create a great customer experience and drive profits.. ...

Nourishing Shampoo for dry, brittle and frayed hair. The specific ingredients, such as Polyglutamic Acid and Proline give nourishment, volume, elasticity and structure to the hair. A special Babassu Oil and Murumuru Butter Complex, together with Hydrolyzed Wheat Proteins and Millefiori Honey Extract protects and nourishes hair leaving it incredibly soft, shiny, healthy and full of body.. USE: apply to damp hair and massage. Rinse thoroughly. Repeat if necessary. ...

In this study, we developed anionic polymer-coated liposome/siRNA complexes (lipoplexes) with chondroitin sulfate C (CS), poly-l-glutamic acid (PGA) and poly-aspartic acid (PAA) for siRNA delivery by intravenous injection, and evaluated the biodistribution and gene silencing effect in mice. The sizes of CS-, PGA- and PAA-coated lipoplexes were about 200?nm and their ?-potentials were negative. CS-, PGA- and PAA-coated lipoplexes did not induce agglutination after mixing with erythrocytes. In terms of biodistribution, siRNAs after intravenous administration of cationic lipoplexes were largely observed in the lungs, but those of CS-, PGA- and PAA-coated lipoplexes were in both the liver and the kidneys, indicating that siRNA might be partially released from the anionic polymer-coated lipoplexes in the blood circulation and accumulate in the kidney, although the lipoplexes can prevent the agglutination with blood components. To increase the association between siRNA and cationic liposome, we used ...

TY - JOUR. T1 - Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells. AU - Fry, D. W.. AU - Yalowich, J. C.. AU - Goldman, I. David. PY - 1982. Y1 - 1982. N2 - The intracellular accumulation of poly-γ-glutamyl derivatives of methotrexate was evaluated in the presence of vincristine or probenecid (agents which raise the intracellular level of free methotrexate) in Ehrlich ascites tumor cells. The results show that both intracellular methotrexate and its metabolites are increased by these agents and that, in the presence of L-glutamine, polyglutamate derivatives are increased by a higher percentage than is methotrexate. From 1 to 50 μM vincristine increased the levels of polyglutamate derivatives from 25 to over 300%, whereas methotrexate was raised from 25 to 80%. Similarly, 50 to 200 μM probenecid increased methotrexate polyglutamate derivatives from 31 to 88%, whereas methotrexate was raised from 0 ...

TY - JOUR. T1 - Pioneer. T2 - A phase III randomized trial of paclitaxel poliglumex versus paclitaxel in chemotherapy-naive women with advanced-stage non-small-cell lung cancer and performance status of 2. AU - Albain, Kathy S.. AU - Belani, Chandra P.. AU - Bonomi, Philip. AU - OByrne, Kenneth J.. AU - Schiller, Joan H.. AU - Socinski, Mark. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2006/5. Y1 - 2006/5. KW - Cathepsin B. KW - Estradiol. KW - Estrogen. KW - Lysosomal proteases. KW - Macromolecular drug conjugate. UR - http://www.scopus.com/inward/record.url?scp=33745886796&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33745886796&partnerID=8YFLogxK. U2 - 10.3816/CLC.2006.n.027. DO - 10.3816/CLC.2006.n.027. M3 - Article. C2 - 16800969. AN - SCOPUS:33745886796. VL - 7. SP - 417. EP - 419. JO - Clinical Lung Cancer. JF - Clinical Lung Cancer. SN - 1525-7304. IS - 6. ER - ...

Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin.

Catalytic characteristics of hexahistidine-containing organophosphorus hydrolase (His6-OPH) and its enzyme-polyelectrolyte complexes with poly-l-glutamic acid or poly-l-aspartic acid (His6-OPH/PLD50), hydrolyzing organophosphorous compounds, and N-acyl homoserine lactones were studied in the presence of various antibiotics (ampicillin, gentamicin, kanamycin, and rifampicin). The antibiotics at concentrations below 1 g·L−1 had a negligible inhibiting effect on the His6-OPH activity. Mixed inhibition of His6-OPH was established for higher antibiotic concentrations, and rifampicin was the most potent inhibitor. Stabilization of the His6-OPH activity was observed in the presence of antibiotics at a concentration of 0.2 g·L−1 during exposure at 25-41 °C. Molecular docking of antibiotics to the surface of His6-OPH dimer revealed the antibiotics binding both to the area near active centers of the enzyme subunits and to the region of contact between subunits of the dimer. Such interactions between

Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. Melanocortin peptides (α-MSH) possess anti-inflammatory properties in many acute and chronic inflammatory models. Our recent studies have shown that α-MSH covalently coupled to poly-l-glutamic acid (PGA-α-MSH) retains anti-inflammatory properties on rat monocytes. This study aimed to define the effects of PGA-α-MSH on dental pulp fibroblasts. Lipopolysaccharide (LPS)-stimulated fibroblasts incubated with PGA-α-MSH showed an early time-dependent inhibition of TNF-α, a late induction of IL-10, and no effect on IL-8 secretion. However, in the absence of LPS, PGA-α-MSH induced IL-8 secretion and proliferation of pulp fibroblasts, whereas free α-MSH inhibited this ...

Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS/MB21D1, leading to impair the nucleotidyltransferase activity of CGAS/MB21D1.

Female patients, must either be not of child bearing potential or have a negative pregnancy test within 14 days of starting study treatment. Patients are considered not of child bearing potential if they are surgically sterile (they have undergone a hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or they are postmenopausal. Pregnant or lactating females are not ...

Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Generates long side-chains (By similarity ...

By converting methotrexate (MTX) into poly-gamma-glutamyl derivatives, cultured human fibroblasts accumulated high intracellular levels of drug. Once polyglutamates had been formed, DNA synthesis and cell growth remained suppressed even after MTX had been removed from the culture medium. Co-cultivation of cells with MTX and folinic acid reversed the effect of MTX on polyglutamate formation, DNA synthesis, and cell growth. However, if folinic acid was added to the culture medium following a preincubation in methotrexate, DNA synthesis initially remained inhibited and cell growth was only gradually restored. Co-cultivation of cells with 0.67 mM glycine, 37.5 micrometers adenosine, and 41.3 micrometers thymidine (GAT) and MTX did not prevent polyglutamate formation but allowed cells to grow. If GAT was removed from the culture medium along with MTX, cell growth and DNA synthesis were inhibited. If GAT was added to the culture medium following growth in MTX, cell growth recovered. These studies ...

ECCO - European Crohn´s and Colitis Organisation. The European Crohn\s and Colitis Organisation is a highly active non-profit association focusing on Inflammatory Bowel Diseases (IBD).

Information for L-Glutamic acid 56-86-0 including L-Glutamic acid CAS NO 56-86-0, L-Glutamic acid Suppliers, L-Glutamic acid Manufacturers, related products of L-Glutamic acid.

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anti-Polyglutamylation Modification, mAb (GT335) (Polyglutamylated Tubulin) is a Monoclonal Antibody specific for Octapeptide EGEGE*EEG Working in ICC, IHC, Immunoprecipitation, Western Blot. Important for Cell Cycle, Tubulin, Polyglutamylation.

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Problem with generic compounds+Unconnected pathway in ECOCYC ( i.e. : ECOCYC: PWY-2161 = Folate polyglutamylation ) Problem in reaction compartment association in ECOCYC ( i.e. : ECOCYC: 2PHENDEG-PWY: Phenylethylamine degradation I) Slideshow 3802359 by thuyet

Watchlists are updated weekly from data provided by the European Chemicals Agency (ECHA), within their terms of service. EcoMole cannot accept responsibility for erroneous or missing data. It is recommended to refer regularly to the lists provided on the ECHA website, and to sign-up for the ECHA newsletter ...

This MassBank Record with Accession KO000852 contains the MS2 mass spectrum of L-Glutamic acid with the InChIKey WHUUTDBJXJRKMK-VKHMYHEASA-N.

1. Шилдт, Г. C++: базовый курс, 3-е издание / Г. Шилдт. - М.: Вильямс, 2015.. 2. Павловская, Т.А. C/C++. Программирование на языке высокого уровня: учебник для ВУЗов / Т.А. Павловская. - СПб.: Питер, 2017.. 3. Шилдт, Г. Полный справочник по C++, 4-е издание / Г. Шилдт. - М.: Вильямс, 2016.. ...

Buy ITS SKIN Power 10 Formula VE Effector for a boost of Vitamin E that penetrates deep into the skin to nourish and hydrate it. Formulated with rose water, vanilla and Boswellia extracts to soothe and brighten your complexion, as well as balance out its oil and moisture levels, for supple and radiant skin all day. This products fast absorbing too and doesnt leave behind any sticky residue on the skin, making this super comfortable to wear. Water, Alcohol Denat., Butylene Glycol, Polyglutamic Acid, Glycerin, Dipropylene Glycol, Ethyl Hexanediol, Carbomer, Ethylhexylglycerin, Triethanolamine, Niacinamide, Phellodendron Amurense Bark Extract, Schizandra Chinensis Fruit Extract, Fragrance, Amylodextrin, Calcium Pantothenate, Maltodextrin, Sodium Ascorbyl Phosphate, Disodium Edta, Pyridoxine Hcl, Tocopheryl Acetate, Silica - Lightweight, quick absorbing essence - Nourishes the skin, hydrating and brightening it - Contains rose water, vanilla and boswellia extracts for supple, radiant skin Rose water -

Nature Republic Soothing & Moisture Aloe Vera 92% Soothing Gel (Tube) ingredients explained: Aloe Vera Leaf Extract (92%), Ethanol, Glyceryl Polyacrylate, Dipropylene Glycol, Butylene Glycol, Glycerin, Propylene Glycol, 1,2-Hexanediol, Polyglutamic Acid, Betaine, Sodium Hyaluronate, Karen Dulcis Extract, Spearmint Extract, Lemon Balm Extract, Carbomer, Peg-60 Hydrogenated Castor Oil, Triethanolamine, Phenoxyethanol, Purified Water, Disodium Edta

Sidmool Snail Brightening Liposome Essence ingredients explained: Snail Secretion Filtrate (30%), Chamaecyparis Obtusa Water, Aqua, Butylene Glycol, Arbutin, Polyglutamic Acid, Lactobacillus/Soybean Ferment Extract, Salix Alba (Willow) Bark Extract, Cinnamomum Zeylanicum Bark Extract, Origanum Vulgare Leaf Extract, Scutellaria Baicalensis Root Extract, Portulaca Oleracea Extract, Biosaccharide Gum-1, Paeonia Suffruticosa Root Extract, Centella Asiatica Extract, SH-Octapeptide-4, SH-Decapeptide-7, SH-Oligopeptide-9, Sodium Hyaluronate, Algin, Salicylic Acid, Hydrolyzed Algin, Aloe Barbadensis Leaf Extract, Chlorella Minutissima Extract, Chlorella Vulgaris Extract, Chlorella Pyrenoidosa Extract, Sea Water (Maris Aqua), Alpha-Arbutin, Adenosine, Carbomer, Arginine, Hydroxyethylcellulose

The therapeutic response to high-dose methotrexate (HD-MTX) therapy for primary central nervous system lymphoma (PCNSL) varies. Polyglutamylation is a reversible protein modification with a high occurrence rate in tumor cells. MTX incorporated into cells is polyglutamylated and strongly binds to dihydrofolate reductase without competitive inhibition by leucovorin (LV). Tumor cells with high polyglutamylation levels are selectively killed, whereas normal cells with lower polyglutamylation are rescued by LV. We hypothesized that the extent of polyglutamylation in tumor cells determines treatment resistance. Here, we investigated the therapeutic response of PCNSL to HD-MTX therapy with LV rescue based on polyglutamylation status. Among 113 consecutive PCNSL patients who underwent HD-MTX therapy in our department between 2001 and 2014, polyglutamylation was evaluated by immunostaining in 82 cases, with relationships between polyglutamylation and therapeutic response retrospectively examined. Human malignant

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TY - JOUR. T1 - Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol. AU - Su, Chen Ying. AU - Chen, Chia Chun. AU - Chen, Hsuan Yu. AU - Lin, Chun Pin. AU - Lin, Feng Huei. AU - Fang, Hsu Wei. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: ...

Attributes soil organism spore former heat resistant Produces amylase protase subtilisin NAT (nattokinase) - fibrinolytic activity 1 gamma-polyglutamic acid (PGA) - calcium absorption 1, acts as dietary fibre to reduce cholesterol 1 bacteriocin Uses Digestive health Natural fungicide for edible plants 3 Anti-fungal activity 3 Anti-bacterial activity 3 Traditional Foods fermented with bacillus subtilis Natto…

Polyamino acids are able to adopt ordered conformations, such as α-helices and β-sheets, through cooperative hydrogen bonding. These conformations impart polyamino acids with various unique properties and functions in biological environments.

Four folate analogues, methotrexate, aminopterin, 10-deazaaminopterin, and 10-ethyl-10-deazaaminopterin were assessed for their ability to be metabolized to poly-γ-glutamyl derivatives in three tumor lines which vary in their sensitivity to these agents. Cytotoxicity of the four analogues against the murine L1210 leukemia and the human Manca B cell leukemia, as determined by a 3-h clonogenic assay, showed aminopterin and the two 10-deazaaminopterin compounds to be approximately equivalent for each cell type and were 3- to 10- (L1210) and 7- to 14-fold (Manca) more potent than methotrexate. In murine Sarcoma 180 cells, 10-ethyl-10-deazaaminopterin and aminopterin were similarly potent but were 5- to 10-fold more potent than 10-deazaaminopterin and 40- to 80-fold more potent than methotrexate. These results could be explained in part by the differences in transport properties and substrate activities for polyglutamylation for each analogue in these cell types.. Initial rates of polyglutamate ...

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013 ...

Product Description:. Poly-L-lysine hydrobromide is a positively charged synthetic polyamino acid having one HBr per lysine unit. It is a crystalline solid soluble in water. Applications for poly-L-lysine hydrobromide include the promotion of cell adhesion to solid substrates for culture dishes or slides, the conjugation to active molecules for improved activities, the layer-by-layer deposition techniques, and the complexation with nucleic acids for gene expression.. For cell culture applications, poly-L-lysine hydrobromide with a molecular weight greater than 30,000 Da is recommended. The poly-L-lysine hydrobromide (MW=52,000 Da) is easier to use because it is less viscous in solution; however, the poly-L-lysine hydrobromide with an higher molecular weight (MW=84,000 Da) has more attachement sites per polymer chain available to the cells.. Our poly-L-lysine hydrobromide has been purified by dialysis, sterile-filtered on 0.2um, lyophilized, and stored under Ar.. Storage Conditions:. Store ...

A form of the anticancer drug paclitaxel combined with a protein called poliglumex that may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of breast cancer, ovarian cancer, lung cancer, and other types of cancer.

The PGSB plant genomics group focuses on the analysis of plant genomes, using bioinformatic techniques. To store and manage the data, we developed a database, PlantsDB, that aims to provide a data and information resource for individual plant species. In addition PlantsDB provides a platform for integrative and comparative plant genome research. ...

The PGSB plant genomics group focuses on the analysis of plant genomes, using bioinformatic techniques. To store and manage the data, we developed a database, PlantsDB, that aims to provide a data and information resource for individual plant species. In addition PlantsDB provides a platform for integrative and comparative plant genome research. ...

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 ...

CB30900 is a novel, potent thymidylate synthase inhibitor which can not be polyglutamated and may be active in cancers expressing low or defective folylpolyglutamate synthetase. Pharmacokinetics were studied in mouse tumors and tissues after bolus or infusion protocols. Elimination was triphasic after 100 mg kg-1 i.v. (T 1/2 alpha, 2.8 min; T 1/2 beta, 19.1 min and T 1/2 gamma, 4.1 hr). Peak concentrations were 716 microM; clearance, 1.19 ml g-1 hr-1; and area under the curve (AUC 0-2 hr), 131 microM hr. Biphasic elimination occurred after i.p. administration and was comparable to the i.v. route giving complete i.p. bioavailability. Kidney concentrations were similar to plasma (AUC 0-2 hr, 84.3 microM hr). CB30900 concentrations in the gut increased steadily with time (AUC 0-2 hr, 645 microM hr) and liver drug concentrations were 7-fold greater than plasma (AUC 0-2 hr, 847 microM hr). Peak tumor concentrations occurred at 30 min and were 27% of plasma concentrations, but tumor drug clearance was ...

Methotrexate is an immunosuprresive disease modifying anti rheumatoid drug or DMARD. Methotrexate is useful in as an anti cancer therapy due to its cytotoxic characteristic. Methotrexate is polyglutamated.

You are viewing an interactive 3D depiction of the molecule n-[(3s)-3-amino-3-carboxypropyl]-l-glutamic acid (C9H16N2O6) from the PQR.

n-[4-({[(2,4-diaminopteridin-6-yl)methyl]amino}methyl)benzoyl]-l-glutamic acid | C20H22N8O5 | CID 190992 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Letvin, N L.; Rock, K L.; Nepom, J T.; G; and Benacerraf, B, Antibody responses to trinitrophenyl (tnp)-l-glutamic acid60- -l-alanine30-l-tyrosine10 (gat) in microcultures: anti-hapten and anti-carrier responses appear to be under separable control. (1982). Subject Strain Bibliography 1982. 3398 ...

L-Glutamic Acid appears as a white crystalline powder. This product is used as a salt substitute, a dietary supplement, a flavor enhancer and also as a...

L-Glutamic acid disodium salt/ACM16690929 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.

13574-13-5 - AJDUMMXHVCMISJ-ZDUSSCGKSA-N - L-Glutamic acid, N-((1,1-dimethylethoxy)carbonyl)-, 5-(phenylmethyl) ester - Similar structures search, synonyms, formulas, resource links, and other chemical information.

125780-86-1 - RDUNYDIEPCWJHF-UKKRHICBSA-N - L-Glutamic acid, 5.5-ester with 3-azido-3-deoxythymidine - Similar structures search, synonyms, formulas, resource links, and other chemical information.