TY - JOUR. T1 - Mirna-93 inhibits glut4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance. AU - Chen, Yen-Hao. AU - Heneidi, Saleh. AU - Lee, Jung Min. AU - Layman, Lawrence C.. AU - Stepp, David W.. AU - Gamboa, Gloria Mabel. AU - Chen, Bo Shiun. AU - Chazenbalk, Gregorio. AU - Azziz, Ricardo. PY - 2013/7. Y1 - 2013/7. N2 - Approximately 70% of women with polycystic ovary syndrome (PCOS) have intrinsic insulin resistance (IR) above and beyond that associated with body mass, including dysfunctional glucose metabolism in adipose tissue (AT). In AT, analysis of the IRS/PI3- K/AKT pathway signaling components identified only GLUT4 expression to be significantly lower in PCOS patients and in control subjects with IR. We examined the role of miRNAs, particularly in the regulation of GLUT4, the insulin-sensitive glucose transporter, in the AT of PCOS and matched control subjects. PCOS AT was determined to have a differentially expressed ...
Polycystic Ovary Syndrome is the most common endocrine disorder in women, is estimated to affect more than 5% of the population and is associated with chronically elevated serum androgen concentrations.Evidence suggests that polycystic ovary syndrome has a negative impact on pregnancy outcomes, with an increased risk of gestational diabetes, hypertensive disease during pregnancy,and preterm birth,which is partially related with the hyperandrogenic environment.Diane-35 has been proved to be the most effective anti-androgenic drug.At present, there is no direct evidence that Diane-35 has a positive effect on the clinical outcome of polycystic ovary syndrome patients undergoing In-vitro fertilization/Intracytoplasmic sperm injection ...
The polycystic ovary syndrome is the leading cause of female infertility in the United States. The disorder affects approximately 6-10% of women of reproductive age. Insulin is a hormone that helps the body to take up sugar from the bloodstream. It is widely accepted that insulin resistance may be responsible for the polycystic ovary syndrome. Women are insulin resistant when their bodies do not respond to insulins action to handle sugar as they normally should. Because of this insulin resistance, when women with the polycystic ovary syndrome become pregnant, they are at a higher risk of developing gestational diabetes. Gestational diabetes carries risk to both the mother and the baby. The purpose of this study is to determine whether certain factors in women with the polycystic ovary syndrome are linked to risk of gestational diabetes. We propose to look at demographic factors, as well as the bodys handling of estrogen (a female hormone present in high quantities during pregnancy) in this ...
You may have heard the term Polycystic Ovary Syndrome before, or the abbreviation of PCOS. But, what does that even mean? Were about to give you the Libra lowdown. Lets do this…. What is Polycystic Ovary Syndrome, and what causes it?. Basically, girls produce the hormone oestrogen, whereas guys have all of that brooding testosterone. The plot twist? In addition to oestrogen, us gals have these things called androgens. (Bear with us, this can get kinda confusing). These are male hormones that females also make.. Sometimes, ovaries pump out more androgens than whats considered normal, and this is called hyperandrogenism. These high levels of male hormones can tamper with our healthy ovulation process, and the imbalance can even cause some weird, little follicles to grow off the ovaries. These follicles lead to the formation of cysts, and thats exactly where the cyst part of Polycystic Ovary Syndrome comes from.. Unfortunately, the exact cause of PCOS is unknown, however links have been ...
Menopause is caused by a gradual fall in a womans hormone levels, while hormonal imbalance causes polycystic ovary syndrome. But can the reduction in sex hormones that bring on menopause cure the imbalance that causes polycystic ovary syndrome? Polycystic ovary syndrome (PCOS) is a condition that leads to cysts growing on a womans ovaries. It happens when…
Centers of Research for Polycystic Ovary Syndrome - Weve compiled a unique directory of doctors, hospitals, medical centers, and research institutions with special interest and, in many cases, clinical expertise in managing people with Polycystic Ovary Syndrome. The "Centers of Research" directory is a valuable resource for quickly identifying and locating leading medical authorities and medical institutions both within the United States and other countries who are considered to be at the forefront in clinical research and treatment of Polycystic Ovary Syndrome. Youd have to spend days - or even weeks - attempting to compile your own list of doctors and medical centers but, with the "Centers of Research" directory, the information is already right at your fingertips. All you have to do is act on the information by selecting and contacting the experts or medical institutions listed in the directory by state and country. ...
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: Multicystic ovaries; Multicystic ovaries; PCOS; Polycystic Ovarian disease; Polycystic ovaries; Polycystic ovaries (disorder); polycystic ovary; Polycystic ovary syndrome; Stein-Leventhal synd.; Stein-Leventhal synd.; Stein-Leventhal syndrome; Stein-Leventhal syndrome
The symptoms of PCOS often date from adolescence and it is no surprise that polycystic ovaries are commonly found in teenagers with menstrual disturbances and/or hirsutism. The typical biochemical abnormalities are often present but it is important to be aware that, as in adults, serum concentrations of LH or testosterone (even in hirsute subjects) may be normal and should not prohibit the diagnosis of PCOS, which is made, primarily, on clinical and ultrasonographic criteria. Polycystic ovaries can be identified on ultrasound, even in prepubertal children. The prevalence of polycystic ovaries increases throughout puberty, reaching 26% by the age of 15.12 Full expression of clinical and endocrine features of polycystic ovary syndrome depends on the maturational changes in the hypothalamic-pituitary-ovarian axis which occur during normal puberty, notably the influence of gonadotrophins on ovarian steroidogenesis. The presence of polycystic ovaries before the onset of puberty suggests that the ...
We offer a variety of treatment options for polycystic ovarian disease. Learn more about the symptoms of polycystic ovarian disease and other gynecology conditions at Houston Methodist.
TY - JOUR. T1 - Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. AU - Chen, Chin I.. AU - Hsu, Ming-I. AU - Lin, Shyh-Hsiang. AU - Chang, Yuan Chin Ivan. AU - Hsu, Chun-Sen. AU - Tzeng, Chii-Ruey. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Aim: The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS). Design: This was a retrospective study. Patients: Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated. Main outcome measure(s): Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated. Results: Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The ...
Polycystic ovary syndrome or PCOS is a common hormonal disorder in women and it involves multiple organs in the body. Even though the name implied multiple cysts in the ovaries, some women may not have cysts in the ovaries. It is estimated that about 5 to 10 percent of women in the U.S have polycystic ovary syndrome.PCOS is often found in women who are in their childbearing age but it can also occur in young girls who just reach puberty.Currently, research studies showed that PCOS runs in the families. If your mother or sister is diagnosed with PCOS, you are at higher chance for having it.. Scientists do not know the exact causes of PCOS yet. Nevertheless, it is found to be associated with imbalance of several hormones including estrogen and progesterone (female hormones), androgen (male hormone), LH and FSH (from pituitary gland in the brain) and insulin. Insulin is the hormone that regulates blood glucose. In a normal menstrual cycle, LH, FSH, estrogen and progesterone play a role in oocyte ...
Polycystic Ovary Syndrome PCOS Definition - Polycystic ovary syndrome (PCOS) is a hormone (endocrine) disorder in which a womens levels of estrogen and...
... Polycystic ovary syndrome (PCOS) affects 5 to 10 percent of women who are of child-bearing age. It is a hormonal disorder that causes obesity, acne, hair growth, and is one of the...
Polycystic Ovary Syndrome (PCOS) natural treatment. Find out the most effective home remedies, herbs, supplements and natural products for Polycystic Ovary Syndrome (PCOS)
The National Health and Medical Research Council (NHMRC) Centre for Research Excellence in Polycystic Ovary Syndrome (CREPCOS) has released the updated evidence-based guideline for the assessment and management of polycystic ovary syndrome for public consultation. The guidelines include recommendations on clinical hyperandrogenism including acne, female pattern hair loss and hirsutism.. The consultation period is open until Monday 12 March 2018. For more information, visit the CREPCOS website ...
Polycystic Ovary Syndrome (PCOS) diagnosis and treatment in Murrells Inlet, SC. Diagnosis and treatment of Polycystic Ovary Syndrome by local hormone specialist.
Frozen embryo transfer during IVF may improve chances for pregnancy in women with polycystic ovary syndrome.. (HealthDay News) - For women with polycystic ovary syndrome (PCOS) seeking infertility treatment, the use of frozen embryos rather than fresh appears to improve the chances for a successful pregnancy, according to a study published in the New England Journal of Medicine.. Richard Legro, MD, a professor of obstetrics and gynecology and public health sciences at Pennsylvania State University in Hershey, and colleagues randomly assigned 1508 infertile Chinese women who had PCOS and who were having their first in vitro fertilization (IVF) cycle to use either fresh or frozen embryo transfer.. Continue Reading Below. The researchers found a higher frequency of live birth after the first transfer when frozen embryos were used (49.3%) than when fresh embryos were implanted (42.0%). At the same time, there was a slightly higher risk of preeclampsia (4.4% vs 1.4%), and newborn death (5 deaths vs ...
TY - CHAP. T1 - The role of insulin-sensitising drugs in the treatment of polycystic ovary syndrome. AU - Legro, Richard. PY - 2010/1/1. Y1 - 2010/1/1. N2 - Insulin-sensitising agents are frequently used in the treatment of women with polycystic ovary syndrome (PCOS) but, to date, the results have fallen short of expectations. Despite their limited benefits, these drugs are widely used in PCOS, and they are probably overprescribed. Insulin-sensitising agents are a class of drugs that work primarily or in part by improving peripheral insulin sensitivity to lower insulin levels and, ultimately, to lower circulating glucose levels. The classic example is the thiazolidinediones (pioglitazone and rosiglitazone). Given the intense endocrine interaction of tissues involved in glucose homeostasis, drugs that target one organ or function often have cross-over benefit on other aspects of glucose homeostasis. For instance, the biguanides primarily suppress hepatic gluconeogenesis but also exert some ...
Almost 1 in 10 women in the UK are diagnosed with Polycystic Ovary Syndrome - why dont we know more about it? Portsmouth-based blogger and broadcaster Laura Mitchell finds out why. In August 2016, I sought advice from my GP for a painful case of acne that had been breaking out on my face for the best part of a year. Around the same time, my periods became irregular; they lost sync for six months, and for the next five stopped altogether.. My GP gave me antibiotics for the acne, but also questioned me on other points. Did I find it difficult to lose weight? Yes - dont we all? Was my hair thinning and falling out? No. I had always had a thick mane of hair.. He rubbed his chin and told me he would like to send me for blood tests. He thought I might have a condition called polycystic ovary syndrome.. Nothing more was said until my blood results came back. My hormone levels were in check, so it was unlikely I had PCOS. However, I was sent for an ultrasound to be sure. The scan showed my ovaries had ...
Current trends in the treatment of polycystic ovary syndrome with desire for children Margalida E Sastre1, Maria O Prat1, Miguel Angel Checa1,2, Ramon C Carreras11Department of Obstetrics and Gynaecology; 2Unit of Endocrinological Gynaecology and Human Reproduction, Hospital del Mar, Autonomous University of Barcelona, Barcelona, SpainAbstract: Polycystic ovary syndrome (PCOS), one of the most frequent endocrine diseases, affects approximately 5%–10% of women of childbearing age and constitutes the most common cause of female sterility regardless of the need or not for treatment, a change in lifestyle is essential for the treatment to work and ovulation to be restored. Obesity is the principal reason for modifying lifestyle since its reduction improves ovulation and the capacity for pregnancy and lowers the risk of miscarriage and later complications that may occur during pregnancy (gestational diabetes, pre-eclampsia, etc). When lifestyle modification is not sufficient, the first step in
... is a chronic lifelong condition that often leads to infertility. What is Polycystic Ovary Syndrome and what are the Symptoms?
Doctors for Polycystic Ovary Syndrome In Adolescence in Hyderabad. Find Doctors Near You, Book Doctors Appointment, Consult Online, View Cost for Polycystic Ovary Syndrome In Adolescence in Hyderabad | Lybrate
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting the women of reproductive age. Vitamin D deficiency may have a role in etiopathogenesis of PCOS and its metabolic and endocrine dysregulations. Various studies have shown conflicting results regarding role of vitamin D in PCOS. Therefore, the aim of this study was to find out vitamin D status in PCOS and its association with various metabolic dysregulations. Methods: This single center prospective case control study included 100 females with PCOS and 100 controls. Participates were evaluated for vitamin D status. Correlation of vitamin D with metabolic dysregulations in PCOS was then done. Results: Vitamin D deficiency was seen in 102 (51%) participants. Vitamin D levels were lower in PCOS group compared to control group (20.9 ± 10.2 vs 27.0 ± 15.6, P value 0.001). Prevalence of Vitamin D deficiency was also more in PCOS group compared to control group (59% vs 43 %, P value 0.024).Vitamin D levels were ...
Approximately 50% to 70% of women with polycystic ovary syndrome (PCOS) have some degree of insulin resistance, and obesity is known to worsen insulin resistance. According to the study by the Ewha Womans University School of Medicine, posted in PubMed, ISI was significantly lower in both lean and ow/ob women with PCOS compared to BMI-matched controls (p,0.05). Increasing BMI by 1 kg/m(2) decreased ISI by 0.169 in PCOS patients (p,0.05) and by 0.238 in controls (p,0.05); there was no significant difference between these groups. In lean PCOS patients and lean controls, BMI had no effect on ISI. Multiple regression analysis revealed that PCOS status (β=-0.423, p,0.001) and BMI (β=-0.375, p,0.001) were significantly associated with ISI. Conclusion: Insulin resistance is an intrinsic defect of PCOS, and a high BMI could exacerbate insulin resistance in all women, irrespective of whether they have PCOS. ...
Infertility in polycystic ovary disease (PCOS) is a hormonal imbalance in women that is thought to be one of the leading causes of female infertility. Polycystic ovary syndrome causes more than 75% of cases of anovulatory infertility. Not all women with PCOS have difficulty becoming pregnant.[citation needed] For those who do, anovulation is a common cause. The mechanism of this anovulation is uncertain, but there is evidence of arrested antral follicle development, which, in turn, may be caused by abnormal interaction of insulin and luteinizing hormone (LH) on granulosa cells. Endocrine disruption may also directly decrease fertility, such as changed levels of gonadotropin-releasing hormone, gonadotropins (especially an increase in luteinizing hormone), hyperandrogenemia, and hyperinsulinemia. Gonadotropins are released by gonadotroph cells in pituary gland, and these cells appear to harbor insulin receptors, which are affected by elevated insulin levels. A reason that insulin sensitizers work ...
Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia, oligo-anovulation, and numerous ovarian cysts. Hospital electronic medical records provide an avenue for investigating polycystic ovary morphology commonly seen in PCOS at a large scale. The purpose of this study was to develop and evaluate the performance of two machine learning text algorithms, for classification of polycystic ovary morphology (PCOM) in pelvic ultrasounds. Pelvic ultrasound reports from patients at Boston Medical Center between October 1, 2003 and December 12, 2016 were included for analysis, which resulted in 39,093 ultrasound reports from 25,535 unique women. Following the 2003 Rotterdam Consensus Criteria for polycystic ovary syndrome, 2000 randomly selected ultrasounds were expert labeled for PCOM status as present, absent, or unidentifiable (not able to be determined from text alone). An ovary was marked as having PCOM if there was mention of numerous peripheral follicles or if the volume was greater than 10
Objective: To evaluate whether the addition of finasteride (a 5 ,-reductase inhibitor) to conventional protocol of ovarian stimulation with gonadotropin can improve ovarian follicular growth in polycystic ovary syndrome (PCOS) women who did not respond to previous stimulation with gonadotropin alone. Design: Double-blind randomized study. Setting: Outpatient in an academic research environment. Patient(s): Thirty-six PCOS patients in whom the previous multifollicular stimulation protocols with gonadotropin failed. Intervention(s): The patients were randomly assigned to two treatment groups: group 1 underwent ovarian stimulation with recombinant FSH (rFSH) plus finasteride, and group 2 received rFSH alone. When the dominant follicle reached a mean diameter of 18 mm, hCG was administered and finasteride withdrawn. Main Outcome Measure(s): Ovulation rate in women with PCOS. Result(s): Follicular growth and ovulation occurred in eight patients in group 1, whereas no cases were detected in group 2. ...
ABSTRACT. Objectives: to evaluate and compare serum adiponectin levels in different phenotypes of polycystic ovary syndrome (PCOS) and to investigate their correlation with endocrine and metabolic parameters. Material and methods: we studied 5 groups of patients: A (n = 20): H (hyperandrogenism) + O (oligoanovulation) + P (polycystic ovary) [classic phenotype]; B (n = 17): H + O [classic phenotype but normal ovaries]; C (n = 15): H + P [Ovulatory phenotype]; D (n = 17): O + P [Normoandrogenic phenotype]; and E (n = 16) control group. Body mass index, waist circumference, waist/hip ratio, blood pressure and hirsutism were evaluated. Serum concentrations of adiponectin, insulin, Creactive protein, SHBG, androgens and lipids were measured. Oral glucose tolerance test was performed. Results: there were no differences between the groups in terms of age and BMI. Total cholesterol, LDL-C and triglyceride levels were higher in phenotype A than in C (P < 0.05); HDL-C was slightly lower in phenotype D ...
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of child-bearing age, with symptoms including irregular periods, elevated male hormone levels, and enlarged ovaries. Untreated, the syndrome can lead to type 2 diabetes and other health problems. According to the PCOS Awareness Association, some of the potential issues women face who suffer from…
3. Polycystic ovaries (PCO) on ultrasound.. AND exclusion of other conditions causing these features.. As you can see from this criteria, a woman does not need to have polycystic ovaries to have PCOS and she does not necessarily have PCOS if she has polycystic ovaries.. How common is PCOS?. PCOS is one of the most common conditions in women of reproductive age, affecting between 12-21% of these women[2]. It is estimated, however, that this could be many more women, because approximately 70% of women with PCOS are undiagnosed.[3]. What are the causes of PCOS?. Unfortunately, it is still unclear what exactly causes PCOS, but we do know that there are many factors that inter-relate and affect each other, to play a role in causing the syndrome. Genetics and environmental factors like diet and lifestyle have an important influence. The underlying hormonal imbalances that arise include increased androgens (male hormones that are normally produced in smaller amounts in women, such as testosterone) ...
Polycystic ovaries are found by ultrasound scan in 25% of all women, but only 5% of women have polycystic ovary syndrome (PCOS). This includes symptoms such as infertility, irregular periods, absent periods, acne, excessive hair growth and weight gain.. PCOS is a complex hormonal condition which is not in itself dangerous and is the commonest cause of irregular periods. But it should be managed carefully depending on the symptoms and reproductive stage of life. It is often best to simply take the contraceptive pill to regulate the periods and keep the ovaries quiet (ie. Prevent the development of larger cysts). In some women who have been on the pill for many years, they only discover they have the condition when they stop taking the pill and dont get their periods back.. The pill is also effective for improving skin and reducing excessive hairgrowth.. If fertility is a problem, there are numerous options which include simple tablets to induce ovulation (eg. Clomid or metformin), low dose ...
Polycystic Ovary Syndrome Over the last few years, there has been an increase in the number of people who suffer from Polycystic Ovary Syndro
The aim of the present study was to identify potential serum biomarkers for insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) by comparing the differences in serum protein expression levels between PCOS patients with and without IR. PCOS patients aged from 18 to 35 years were recruited at Guangdong Women and Childrens Hospital from January, 2013 to February, 2014. A total of 218 PCOS patients were enrolled and divided into the insulin resistance (PCOS‑IR) and non‑insulin resistance (PCOS‑NIR) groups according to their homeostasis model assessment of insulin resistance. Two‑dimensional difference gel electrophoresis (2D‑DIGE) and matrix‑assisted laser desorption/ionization time‑of‑flight mass spectrometry (MALDI‑TOF‑MS/MS) techniques were used to identify differences in protein expression levels between the PCOS‑IR and PCOS‑NIR groups. The present study demonstrated that the total cholesterol (TCH), triglycerides (TG), low‑density lipoprotein ...
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Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that affects female fertility. However, with the lack of a corresponding research model, the pathology mechanism of PCOS is poorly understood. Induced pluripotent stem cell (iPSC) technology has been recognized as means to generate patient-specific stem cells for disease modeling. The mRNA abundance of iPSCs was analyzed by RNA microarray and real-time polymerase chain reaction (RT-PCR). Karyotyping of iPSCs was performed with cytogenetic analysis. The mitochondrial respiration ability and glycolytic function were measured by the Seahorse Bioscience XF extracellular flux analyzer. The expression of iPSC-associated markers was identified by immunofluorescence and RT-PCR. The teratoma formation of iPSCs was studied using immunochemistry. A PCOS patient-derived iPSC model was established from somatic cells of PCOS patients. Through comprehensive transcriptional profiling analysis of the RNA microarray, PCOS patient-derived iPSCs
Polycystic ovarian disease is an endocrine disorder that is one of the commonest causes of infertility in women. Women develop small cysts in their ovaries that disrupt their menstrual cycle.
Treatments And Drugs. The treatment of PCOS depends partially on the womans age and stage in life. For younger women who desire birth control, the birth control pills, especially with low androgenic side effects, could cause regular periods and prevent the risk of uterine cancer.. The other option could be intermittent therapy with the treatment of progesterone. Polycystic ovary syndrome treatment generally focuses on management of individual concerns of the women such as infertility, hirsutism, acne or obesity.. Surgery. If medications do not work, an outpatient surgery called laparoscopic ovarian drilling could be suggested by the doctor to induce ovulation, which can be performed at Apollo Cradle, under expert supervision.. ...
Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age, and its etiology remains poorly understood. Altered activities of long noncoding RNAs (lncRNAs) have been associated with human diseases and development. However, the roles of lncRNAs are unknown in reproductive medicine. Researchers from the Southern Medical University investigated the potential role of lncRNAs in the pathogenesis of PCOS, using human granulosa cells (GCs) and the KGN cell line. They used microarrays to compare lncRNA expression profiles in GCs from 7 PCOS patients and 7 matched women. GC samples were collected during 2014-2016 from infertile women in Guangzhou, China. Quantitative real-time PCR was used to measure levels of the lncRNA HCG26 in GCs from 53 PCOS patients and 50 controls. HCG26 was knocked down with locked nucleic acid GapmaRs in KGN cells to examine the role of HCG26 in cell proliferation, aromatase and FSH receptor gene expression, and estradiol ...
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STUDY QUESTION Are circulating microparticles (MPs) altered in young women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Women with PCOS have elevated concentrations of circulating platelet-derived MPs, which exhibit increased annexin V binding and altered microRNA (miR) profiles compared with healthy volunteers. WHAT IS KNOWN ALREADY Some studies have shown that cardiovascular risk is increased in young women with PCOS but the mechanisms by which this occurs are uncertain. Circulating MPs are elevated in patients with cardiovascular disease but the characteristics of MPs in patients with PCOS are unclear. STUDY DESIGN, SIZE, DURATION Case-control study comprising 17 women with PCOS (mean ± SD; age 31 ± 7 years, BMI 29 ± 6 kg/m2) and 18 healthy volunteers (age 31 ± 6 years, BMI 30 ± 6 kg/m2). PARTICIPANTS/MATERIALS, SETTING, METHODS The study was conducted in a University hospital. Nanoparticle tracking analysis (NTA) and flow cytometry (CD41 platelet, CD11b monocyte, CD144 ...
Polycystic ovary syndrome (PCOS) is a common reproductive endocrinology disease with heterogeneous phenotype. Environmental factors are thought to be involved in the development of PCOS. The present study aimed to explore the potential environmental risk factors of PCOS. A cross-sectional study and stratified population-based case-control study were carried out. Pre-designed questionnaires were prepared, including questions about medication history, contact history of endocrine disruptors (EDs), environment and habituation. Fasting blood was collected for measurement of sex hormone, glucose and insulin. Matched logistic regression analysis was used to find the potential independent risk factor of PCOS. One thousand eight hundred fifty-four participants (aged 12-44 years) were analyzed in the cross-sectional investigation. One hundred sixty-nine PCOS patients and 338 matched controls were compared. PCOS patients were more frequent than controls in eating plastic-packaged food (p=0.001), contacting
The DENND1A gene is one of the most important sites associated with polycystic ovary syndrome (PCOS). We attempted to analyze the correlation between five single nucleotide polymorphisms (SNPs) in the DENND1A gene and the development of PCOS. A total of 346 PCOS patients and 225 normal ovulatory women were involved in the case-control study. Clinical variables and hormones were recorded. According to the Hap Map database, five tagging SNPs (rs2479106, rs2768819, rs2670139, rs2536951 and rs2479102) in the DENND1A gene were identified. The TaqMan probe and the PCR-RFLP (restriction fragment length polymorphism) methods were used for revealing these genotypes. TaqMan Genotype Software was used to analyze the alleles of the five SNPs. Linkage disequilibrium and the gene frequency analysis demonstrated that the CCGGG haplotype might increase the risk of PCOS (P = 0.038, OR = 1.89, 95% CI = 1.027-3.481). Significant differences were found in genotypic and allelic distributions at the rs2536951 and rs2479102
Context: Insulin resistance, which associates with levels of retinol-binding protein 4 (RBP4) and adiponectin, is implicated in the development of polycystic ovary syndrome (PCOS).. Objective: The objective of the study was to explore the potential contribution of RBP4 and adiponectin in the etiology of PCOS and their relationships with specific fat depot measurements.. Design: This was a cross-sectional study.. Setting and Participants: Serum RBP4 and adiponectin levels were compared between 50 PCOS cases and 28 female controls (including 22 body mass index/fat mass-matched pairs) and correlated with specific fat depot (including visceral) axial magnetic resonance imaging cross-sectional area measurements. All subjects were of U.K. British/Irish origin.. Main Outcome Measure(s): Serum levels of RBP4 (automated immunonephelometric assay) and adiponectin [immunoassay: total and high molecular weight (HMW)]. Data are reported as geometric mean (SD, range) and optionally adjusted for fat mass and ...
Insulin resistance is one of the common features of the polycystic ovary syndrome (PCOS), and recent studies indicate the possible role of vitamin D in the pathogenesis of insulin resistance and inflammatory response. We aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and insulin resistance and inflammatory marker in obese women with PCOS and controls.. We recruited 50 obese women with PCOS (age 25±5 years, BMI 27.5±2.3 kg/m2) and 50 age, BMI-matched controls (age 26±5 years, BMI 27.3±2.1 kg/m2). Anthropometric measurements were obtained and metabolic and hormonal parameters were determined. Serum 25(OH)D levels were measured by IRMA (COBRA Quantum 5002) and hsCRP by TIA (ADVIA 2400). Glucose tolerance status was assessed by 75 g OGTT, and insulin resistance index was calculated from OGTT data.. The prevalence of insufficient 25(OH)D levels (,30 ng/ml) were 90% in women with PCOS and 88% in controls. Serum 25(OH)D and hsCRP concentrations are not different between ...
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disease characterized by hyperandrogenism and insulin resistance. It results in irregular menstruation, obesity and even infertility, which influences badly physical and mental health of the patients. Now, there is no effective drug for treating PCOS and the preferred program is lifestyle modification, including diet control, regular exercise and behavior therapy. Therefore, in the review, we summarize the study progress concerning the effects of lifestyle intervention on the metabolic, reproductive and psychological dysfunctions of PCOS patients and analyze the corresponding mechanisms in these processes. It can radically reduce the factors of PCOS occurrence and development, while providing valuable information for the prevention and treatment of PCOS and is helpful for further research.
Daniel A. Dumesic, M.D., JoAnne S. Richards, Ph.D.. Volume 100, Issue 1, Pages 23-38, July 2013. Abstract:. Activation of primordial follicles into the growing pool, selection of the dominant follicle and its eventual ovulation require complex endocrine and metabolic interactions, as well as intraovarian paracrine signals to coordinate granulosa cell proliferation, theca cell differentiation and oocyte maturation. Early preantral follicle development relies mostly upon mesenchymal-epithelial cell interactions, intraovarian paracrine signals and oocyte-secreted factors, while development of the antral follicle depends upon circulating gonadotropins as well as locally-derived regulators. In women with polycystic ovary syndrome (PCOS), ovarian hyperandrogenism, hyperinsulinemia from insulin resistance and altered intrafollicular paracrine signaling perturb activation, survival, growth and selection of follicles, causing accumulation of small antral follicles within the periphery of the ovary, ...
The current systematic review with meta-analysis of randomized controlled trials (RCTs) was aimed to evaluate the effects of metformin on reproductive outcomes in patients with polycystic ovary syndrome (PCOS) who receive gonadotropins for ovulation induction. After systematic review of electronic databases and websites for registration of RCTs, a total of 7 RCTs reporting data on 1023 cycles were included in the final analysis. Descriptive data showed an overall low studies quality due to unclear sequence generation and allocation concealment, lack of blinding procedure, incomplete outcome data and several biases and/or confounders. Data synthesis showed that metformin improved live-birth (odds ratio [OR] = 1.94, 95% confidence interval [CI] 1.10 to 3.44; P = 0.020) and pregnancy (OR = 2.25, 95% CI 1.50 to 3.38; P , 0.0001) rates, without significant heterogeneity across the studies (P = 0.230, estimation of inconsistency = 30%; and P = 0.710, estimation of inconsistency = 0%, respectively, ...
Objective To estimate the incidence and prevalence of polycystic ovary syndrome (PCOS) in UK primary care and investigate prescribing patterns before and after a PCOS diagnosis. Design Retrospective cohort study. Setting UK primary care (2004-2014). Participants Women aged 15-45 years. Primary and secondary outcome measures The incidence and prevalence of diagnosed PCOS and probable PCOS (ie, those without a confirmed diagnosis but with at least 2 PCOS features recorded within 3 years). Among women with diagnosed or probable PCOS, the prevalence of prescribing of drugs typically used to treat PCOS was calculated prior to and in the 24 months after the diagnosis of PCOS. Results We identified 7233 women with PCOS diagnoses and 7057 women with records suggestive of probable PCOS, corresponding to incidence rates of 0.93 and 0.91 per 1000 person-years at risk (PYAR) and an overall rate of 1.84 per 1000 PYAR. Women aged 20-24 years and women living in deprived areas had the highest incidence of PCOS. The
Background & aim: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder. Recently, the tendency towards complementary therapies such as using herbs with anti-androgenic effects has been increased. This study reviewed the documents related to the effect of four types of herbal teas on the treatment of PCOS based on the literature review. Methods: The searched databases included ISI, PubMed, Google Scholar, Scopus, Science Direct, Cochrane library, International Clinical Trials registry, MedLib, Society for Information Display (SID), Iranian Registry of Clinical Trials (IRCT), IranMedex and Magiran,. The databases were searched for the clinical trials without any time limit and using English and Persian key terms included
Polycystic ovary syndrome (PCOS) is associated with an increased incidence of insulin resistance (IR), obesity, and type 2 diabetes. According to the study by the Polish Mothers Memorial Hospital-Research Institute in Lodz, potsed in PubMed, in women with PCOS, whether there is a relationship between adiponectin and resistin and the indices of IR, and whether serum levels of these adipocytokines are altered by glucose-induced hyperinsulinaemia. Serum levels of resistin and adiponectin were measured at 0, 60, and 120 min during 75 g oral glucose tolerance test (OGTT), in 19 women with PCOS, age 36.3+/-11.4 years (mean+/-SD), body mass index (BMI) 29.3+/-7.7 kg/m2, and correlated with the indices of IR, such as HOMA-IR, QUICKI, and the insulin resistance index calculated from glucose and insulin levels obtained during OGTT. There was no change in resistin concentrations (7.31+/-4.58, 7.47+/-5.40, 7.22+/-5.12 pg/ml, at 0, 60, and 120 min of OGTT, respectively, P = 0.77), but there was an increase ...