From Ampligen to Autoimmune. Due to the over-due nature of this particular blog posting the length might pose somewhat of an issue for some readers. I thought it best to break it up by dividing it into sections.. """""""""""""""""""""""""""`. My last Ampligen infusion was Feb. 3rd. As you may remember I stopped because of constant bronchitis / pneumonia and transient brief blindness. (Mostly the brief episodes of blindness.) When I stopped the Ampligen I was sent to an ophthalmologist who concluded that my eyes were anatomically fine, but the risk of blindness associated with the continuation of Ampligen was too great. When I stopped Ampligen I was enjoying a happy existence of about a 60 -70 KPS which was a far cry from the 40 where I started.. About two weeks after stopping Ampligen an old, familiar feeling began to creep into my hands and wrists and I cried because I knew what was coming next…. """"""""""""""""""""""""""""`. A brief recap -. I was diagnosed with CFS in 1989. Every test, ...
From Ampligen to Autoimmune. Due to the over-due nature of this particular blog posting the length might pose somewhat of an issue for some readers. I thought it best to break it up by dividing it into sections.. """""""""""""""""""""""""""`. My last Ampligen infusion was Feb. 3rd. As you may remember I stopped because of constant bronchitis / pneumonia and transient brief blindness. (Mostly the brief episodes of blindness.) When I stopped the Ampligen I was sent to an ophthalmologist who concluded that my eyes were anatomically fine, but the risk of blindness associated with the continuation of Ampligen was too great. When I stopped Ampligen I was enjoying a happy existence of about a 60 -70 KPS which was a far cry from the 40 where I started.. About two weeks after stopping Ampligen an old, familiar feeling began to creep into my hands and wrists and I cried because I knew what was coming next…. """"""""""""""""""""""""""""`. A brief recap -. I was diagnosed with CFS in 1989. Every test, ...
Anita Patton, Mary Schweitzer, Bob Miller and Kelvin Lord have all documented their Ampligen success stories. Several experienced significant improvement while on it only to relapse while off it. Anita Patton essentially went from bed bound to normal functioning on Ampligen, back to being bed bound off of it, and then again to normal functioning when back on the drug.. Kelvin Lords story was perhaps most representative. Hes provided the most complete (and funniest) review of an ME/CFS patients experience with Ampligen in a series of blogs titled "The Ampligen Chronicles". Faced with rapidly deteriorating health, Ampligen was Kelvin Lords last shot at health. To his surprise and delight it worked.. It didnt return this businessman, flight instructor, skier and parasailor to complete health, but Kelvin did progress from being barely able to walk to be able to work 6 hours and do 45 minutes of resistance exercises a day. His brain fog, orthostatic intolerance, canker sores and extreme fatigue ...
Treatment of patients with HIV infection must address both the primary viral infection and the subsequent immune deficiency, which is the primary cause of mortality in AIDS. In vitro studies of ampligen have shown it will inhibit HIV infection. Ampligen may also minimize the toxicity of many drugs used in the treatment of AIDS and induce an antiviral state in the brain that may be useful in treating neurologic symptoms of HIV infection. The time course and degree of immunologic response to ampligen remain unknown although they are essential for proper use of the drug in the treatment of HIV infection and perhaps other clinical problems.. Ten healthy volunteers and 10 HIV-infected patients are randomized between ampligen or placebo group. Five volunteers in each group receive a single dose of ampligen on day 1 and a single dose of placebo on day 8. The other 5 volunteers receive the drug and placebo on day 8 and 1, respectively. Seven days of observation and testing follow each administration of ...
PHILADELPHIA, June 21, 2011 (GLOBE NEWSWIRE) -- Hemispherx Biopharma, Inc. (NYSE Amex:HEB) (the Company or Hemispherx) today announced that it has entered into a Material Transfer and Research Agreement with the University of Pennsylvania School of Medicine to provide Ampligen® [rintatolimod; poly(I)·poly(C12,U)], an experimental therapeutic, for testing as a vaccine adjuvant in a human clinical study in ovarian cancer.
Hemispherx Biopharmas Ampligen® is being tested in combination with an experimental ovarian cancer vaccine developed by the Penn Ovarian Cancer Research Center. Hemispherx Biopharma, Inc. (
What is the connection, if any? Hemispherx is making advances in getting approval in various countries. Could Ampligen play a part in light of...
OBJECTIVES:. I. To choose the most promising (maximum biologic dose [MBD]) of five different doses (4, 20, 79, 495 and 2000 mcg) of Ampligen (rintatolimod) administered intradermally (i.d.) as an adjuvant with HER2 vaccination, with respect to toxicity and incidence and magnitude of immune response.. II. To determine, using MBD of Ampligen (defined in first primary aim), whether Ampligen when given with GM-CSF as a combined adjuvant strategy with HER2 vaccination increases both the incidence and magnitude of HER2 Th1 immunity as compared to the standard GM-CSF adjuvant strategy.. OUTLINE: This will be a phase I-II randomized two-stage HER2 vaccine study in breast cancer patients.. STUDY STAGE I: There are five groups of patients randomized to 1 of 5 arms with each arm receiving the synthetic HER-2/neu peptide vaccine admixed with rintatolimod (different doses) given i.d.. STUDY STAGE II: Patients are randomized to 1 of 2 treatment arms.. ARM I: Patients receive the synthetic HER-2/neu peptide ...
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PHILADELPHIA, May 31, 2017-- Hemispherx Biopharma announced today that it continues to build its manufacturing and scientific capabilities with the promotion of Carol Smith, Ph.D., as the Chief Manufacturing Officer and Deputy Chief Scientific Officer.. David Strayer, Chief Scientific and Medical Officer, to assist in managing the Companys scientific,...
Encouraged by the countrys strong economy and increasing consumer spending power, international hotel companies have shifted their interests from the mature markets in the US and Europe to Asia, and China in particular, while domestic hotel companies
Mr. Tony Wong | Rating: 0 | Vote for your professor today! The details of your professors and Professors in your university are all here.
Methods Totally 9 mouse strains were studied including NZB, NZW, NZBW F1, MRL/lpr, MRL/Mp, BXSB/Mp, BXSB.B6.Yaa, B6.SLE1.2.3 and C57BL/6. Spleen, thymus, bone marrow and lymph node pDCs were collected from mice in different disease stages by using Nycodenz enrichment and sorting systems. Human pDCs from healthy donor and SLE patients were isolated by using BDCA4 beads selection. Mouse pDCs were stimulated with ODN2216 and Poly U for Tlr9 and Tlr7 respectively. Human pDCs were stimulated with ODN2216 and R837 for Tlr9 and Tlr7 respectively. After 18 hour for human and 36 hour for mouse, supernatant was collected for ELISA test. IFNa, TNFa, and IL6 were tested. ...
Got pathogen problems? Discuss how youre trying to get rid of them. Antibiotics, Ampligen, Interferons, Nexavir, Valcyte, Valtrex, Vistide, Artesunate, etc. all are open game here.
I have been able to lower the viral load to almost normal levels, the only "but" is the IgM of my EBV that still remains slightly positive, but the titer of the IgGs is now normalized, and this shows also in my symptoms, I can do sports again and even sweet in the gym!!! and I do not have a constant nausea, nor fatigue morning feeling as before... If one of your main problems is the serology of these viruses, I guess you should give it a go. It did work on me, and besides is safe non toxic treatment, like could be Valcyte, Ampligen, Zelitrex, etc ...
So there you have it. I have been back on Ampligen now for ten months. I can read again, I can drive a car, I can walk along Lake Tahoe, and all the symptoms I associate with encephalitis and meningitis - that is, encephalomyelitis - are gone. But I still suffer from pain, and stamina is still a major problem. My VO2 MAX scores remain abysmal. Unfortunately, since this drug is delivered by twice-weekly infusions, I am forcibly separated from my husband of 35 years, which to me is a terrible hardship. But then I see so many others with my disease who have suffered more, and I think I should not say much about being so homesick, about missing my dearest husband so much. After all, Lake Tahoe is not such a bad place to be marooned ...
So there you have it. I have been back on Ampligen now for ten months. I can read again, I can drive a car, I can walk along Lake Tahoe, and all the symptoms I associate with encephalitis and meningitis - that is, encephalomyelitis - are gone. But I still suffer from pain, and stamina is still a major problem. My VO2 MAX scores remain abysmal. Unfortunately, since this drug is delivered by twice-weekly infusions, I am forcibly separated from my husband of 35 years, which to me is a terrible hardship. But then I see so many others with my disease who have suffered more, and I think I should not say much about being so homesick, about missing my dearest husband so much. After all, Lake Tahoe is not such a bad place to be marooned ...
So there you have it. I have been back on Ampligen now for ten months. I can read again, I can drive a car, I can walk along Lake Tahoe, and all the symptoms I associate with encephalitis and meningitis - that is, encephalomyelitis - are gone. But I still suffer from pain, and stamina is still a major problem. My VO2 MAX scores remain abysmal. Unfortunately, since this drug is delivered by twice-weekly infusions, I am forcibly separated from my husband of 35 years, which to me is a terrible hardship. But then I see so many others with my disease who have suffered more, and I think I should not say much about being so homesick, about missing my dearest husband so much. After all, Lake Tahoe is not such a bad place to be marooned ...
So there you have it. I have been back on Ampligen now for ten months. I can read again, I can drive a car, I can walk along Lake Tahoe, and all the symptoms I associate with encephalitis and meningitis - that is, encephalomyelitis - are gone. But I still suffer from pain, and stamina is still a major problem. My VO2 MAX scores remain abysmal. Unfortunately, since this drug is delivered by twice-weekly infusions, I am forcibly separated from my husband of 35 years, which to me is a terrible hardship. But then I see so many others with my disease who have suffered more, and I think I should not say much about being so homesick, about missing my dearest husband so much. After all, Lake Tahoe is not such a bad place to be marooned ...
A number of drugs which act on the bodys immune system (immunomodulatory drugs) have been suggested as possible forms of treatment for sub-groups of people with ME/CFS. These drugs include Ampligen,…. ...
It means that Ampligen will be most likely approved by the FDA. Ampligen, made by Hemispherx, regulates the RnaseL pathway, and has had success with a good number of patients. Dr. Charles Lapp is particularly upbeat about Ampligen, reporting that he gets good results with patients. Ampligen is infused through an IV, twice a week. Hemispherx is run by a bunch of bozos. They have dithered with the FDA, and screwed up the trials and the protocols for twenty-five years - even though Ampligen is seen as a functional drug for some people. As has been suggested by others, the FDA is complicit in this poorly managed process. Regardless of who is to blame the fact remains that this drug is at a standstill. This PA met a fellow in Reno who regained his normal activities for a number of years on this drug. Subsequently mismanagement by Hemispherx (or the FDA or both) cut him off from access to the drug. He got worse. Then he was able to get back on it, and he got better, and then the company cut him off ...
It means that Ampligen will be most likely approved by the FDA. Ampligen, made by Hemispherx, regulates the RnaseL pathway, and has had success with a good number of patients. Dr. Charles Lapp is particularly upbeat about Ampligen, reporting that he gets good results with patients. Ampligen is infused through an IV, twice a week. Hemispherx is run by a bunch of bozos. They have dithered with the FDA, and screwed up the trials and the protocols for twenty-five years - even though Ampligen is seen as a functional drug for some people. As has been suggested by others, the FDA is complicit in this poorly managed process. Regardless of who is to blame the fact remains that this drug is at a standstill. This PA met a fellow in Reno who regained his normal activities for a number of years on this drug. Subsequently mismanagement by Hemispherx (or the FDA or both) cut him off from access to the drug. He got worse. Then he was able to get back on it, and he got better, and then the company cut him off ...
It means that Ampligen will be most likely approved by the FDA. Ampligen, made by Hemispherx, regulates the RnaseL pathway, and has had success with a good number of patients. Dr. Charles Lapp is particularly upbeat about Ampligen, reporting that he gets good results with patients. Ampligen is infused through an IV, twice a week. Hemispherx is run by a bunch of bozos. They have dithered with the FDA, and screwed up the trials and the protocols for twenty-five years - even though Ampligen is seen as a functional drug for some people. As has been suggested by others, the FDA is complicit in this poorly managed process. Regardless of who is to blame the fact remains that this drug is at a standstill. This PA met a fellow in Reno who regained his normal activities for a number of years on this drug. Subsequently mismanagement by Hemispherx (or the FDA or both) cut him off from access to the drug. He got worse. Then he was able to get back on it, and he got better, and then the company cut him off ...
Drug company Hemispherx Biopharma, Inc. announces applications for its experimental therapeutic drug Ampligen to be approved as a treatment for Chronic Fatigue Syndrome.
Sixteen compounds related to GTP were evaluated as inhibitors of bacteriophage-Q beta poly(C)-dependent poly(G) polymerase. Non-phosphorylated compounds, including guanine, guanosine and deoxyguanosine, were inactive. Phosphorylated compounds gave significant inhibition at millimolar concentrations. For nucleotides the feature important for inhibition was the 5′-phosphate chain. Four triphosphates, XTP, ITP, 7-methyl-GTP and 2′-O-methyl-GTP, gave 50% inhibition of both the poly(C)- and poly(U2,C)-dependent reactions at concentrations from 0.1 to 5 mM. XTP was 10-fold more potent an inhibitor of the reaction with poly(U2,C) as template. None of these four compounds was able to substitute for GTP as substrate to a significant extent. The most active compound, 2′-O-methyl-GTP, was a competitive inhibitor (Ki = 0.4 mM) of GTP in the poly(C)-dependent reaction. ...
The Library actively supports the Universitys mission by providing integrated and timely access to high quality scholarly resources, an inspiring environment for intellectual growth and discovery, with responsive and outreaching services... [read more ]. ...
The Library actively supports the Universitys mission by providing integrated and timely access to high quality scholarly resources, an inspiring environment for intellectual growth and discovery, with responsive and outreaching services... [read more ]. ...
3. Earlier this week NIH issued a major press release on the creation of a vaccine for Epstein-Barr Virus. Presumably, then, EBV is a serious disorder. That paragraph says not to test for EBV unless you are excluding a diagnosis of CFS. I have tested positive for EBV at least seven documented times. I just got over a recent bout of active EBV. Unlike the other viruses that are active when I am not on Ampligen (a Phase III immune modulator that I have been taking since 1999) EBV comes and goes. The press release makes it sound as if that is important information. I have three questions about that, then ...
AAFP insults CFS sufferers; patient petition on Ampligen; Dr. Hyde video; major ME/CFS & GWS patient conference; Bartonella & CFS; dont let DSM-5 lab
In Argentina, rintatolimod (Ampligen) has just been commercially approved for the severe disabling form of ME/CFS. The number of patients with ME/CFS is estimated to be over three million worldwide, however, only a portion of these have the severe and disabling form of the disease which we are targeting with this drug," stated Tom Equels. "Until now, there has been no commercially available effective treatment and there are no advanced clinical candidates, other than rintatolimod, that we are aware of. This commercial approval in Argentina will dramatically improve our ability to treat patients suffering from severe ME/CFS in Latin America. We continue to work aggressively to clarify a path toward approval for those with severe ME/CFS in the United States, where we have Orphan Drug status, and therefore seven years of product exclusivity upon approval. We are greatly encouraged by this new regulatory approval in Argentina. This is the most significant accomplishment to date in Hemispherxs plan ...
PolyU has long been committed in addressing unmet global needs through innovation, and striving for food safety and quality is no exception. With the ever-arising issues such as the use of gutter oil, sale of vampire meat in China, food fraud and other issues hitting headlines in recent years and yet to be tackled by cutting-edge technologies, PolyU is determined to bring together academic expertise (U), industry needs (I), and viewpoints from regulatory bodies and governmental organizations (G) to synergize our efforts in restoring consumer confidence. We deliver to you our inaugural issue of Empowering Food Safety and Quality to share our efforts and latest events, research and innovations, news, and how you could participate in our upcoming initiatives to capture the synergies generated from UIG triple helix and through multidisciplinary collaborations. We are also excited to introduce the DISH Global Centre for Food Safety and Quality, which is a non-profit alliance of four economies - ...
PHILADELPHIA, May 21, 2014 (GLOBE NEWSWIRE) -- Hemispherx Biopharma, Inc. (NYSE MKT:HEB) (the Company or Hemispherx), announced the preliminary stage agreement required to manufacture Ampligen® in Argentina in order to serve Latin American markets should Ampligen® be approved in Argentina.
I personally have taken this medicine for 19 years in the FDA clinical trial of AMP-511 and can tell you beyond a shadow of a doubt and have the laboratory...
Codon-specific Markov process for translation elongation based on 12 ribosomal states for each codon .The elongation cycle starts in state 0 corresponding to a
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A carboxy-terminal peptide of the poliovirus replicase protein (p63) was chemically synthesized, coupled to bovine serum albumin carrier, and injected into rabbits. The resulting antisera reacted with six virus-specific proteins from HeLa cells infected with poliovirus: NCVP 0b, NCVP 1b, NCVP 2, a protein of about 60,000 daltons, p63, and NCVP 6b. The identity of the 60,000-dalton protein is not known, but the other results were consistent with previous experimental approaches which demonstrated that p63 and the other four polypeptides have common coding sequences. An amino-terminal peptide of p63 failed to elicit an immune response in rabbits. Antibodies raised against the p63 carboxy-terminal peptide inhibited poliovirus replicase and polyuridylic acid polymerase activities in vitro, providing strong support for earlier suggestions that these activities are a property of a single virus-specific polypeptide. ...
(PRWEB) July 21, 2015 -- Breastfeeding has become more common all across the world in recent years, however, breastfeeding rate has remained low in Hong Kong.
See how 3D modeling provided an effective visualization of the patients complex facial structures with help from 3D printing technology.
U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3 end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA (279 aa ...
FEATURE ARTICLES - February 4, 2004:* Treating Fibromyalgia: The Muscle Pain Epidemic* Research: Glucosamine Boosts NSAID for More Effective Pain Relief (Fibromyalgia News)* Phase 3 Clinical Trial of Ampligen for Chronic Fatigue Syndrome Completed
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Returns an xcb_void_cookie_t. Errors (if any) have to be handled in the event loop.. If you want to handle errors directly with xcb_request_check instead, use xcb_poly_point_checked. See xcb-requests(3) for details.. ...
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A technique that permitted the reversible dissociation of rat liver ribosomes was used to study the difference in protein-synthetic activity between liver ribosomes of normal and hypophysectomized rats. Ribosomal subunits of sedimentation coefficients 38S and 58S were produced from ferritin-free ribosomes by treatment with 0.8m-KCl at 30°C. These recombined to give 76S monomers, which were as active as untreated ribosomes in incorporating phenylalanine in the presence of poly(U). Subunits from normal and hypophysectomized rats were recombined in all possible combinations and the ability of the hybrid ribosomes to catalyse polyphenylalanine synthesis was measured. The results show that the defect in ribosomes of hypophysectomized rats lies only in the small ribosomal subunit. The 40S but not the 60S subunit of rat liver ribosomes bound poly(U). The only requirement for the reaction was Mg2+, the optimum concentration of which was 5mm. No apparent difference was seen between the poly(U)-binding ...
Prof. Lu is a pioneering researcher in the fields of material science and engineering, mechanical engineering and mechanics. In studying nano-scale structural materials, the research teams leaded by Prof. J.Lu and his collaborator Prof. K.Lu (IMR, CAS) put forward the idea of "Nitriding Iron at Lower Temperatures" to refine the microstructure on the surface layer of an iron plate, and the article was published in the Science Magazine (January 31, 2003 issue). He also co-invented the SMAT together with Prof. Lu Ke of the Chinese Academy of Sciences with several issued patents in Europe, USA and China. The sophisticated SMAT process could bring about a change in surface microstructure through generating an in-situ nanocrystalline layer on the surface of bulk metal. While most surface-modification techniques for solid materials are based on chemical reactions, SMAT seeks to reduce the grains sizes down to nanometer scale on the top surface layer through random mechanical plastic deformation. Hence ...
PHILADELPHIA, Sept. 21, 2015-- Hemispherx Biopharma announces the publication of an online peer reviewed research article of an analysis of clinical data on its investigational therapeutic, Ampligen, entitled, Chronic Fatigue Syndrome/Myalgic Encephalomyelitis; Characteristics of Responders to Rintatolimod in the current issue of Journal of Drug...
Several years of research and trials have resulted in a unique formula using low concentration Valerian essential oil, blended with Vetiver, Sweet Basil, and Sage. Pet Remedy works alongside the brains natural messengers called neuro-transmitters, which work by telling the nerve receiving the message either to calm ( via GABA pathway) or get fired up.. In times of stress or anxiety the nerves get over stimulated, which leads on to the many different signs of stress we see in our pets.. The special Pet Remedy blend of essentials oils works alongside these natural relaxation pathways to help calm the nerves of anxious or stressed pets.. Easy to use with trigger ...