Image_5_Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells.TIF
The purpose of this study was to evaluate the efficacy and safety of volumetric modulated arc therapy (VMAT) after extrapleural pneumonectomy (EPP) in patients with malignant pleural mesothelioma (MPM). A total of 15 patients who received VMAT after EPP were enrolled. All patients were males, and the median age was 67 years (Stage IB in two, II in six, and III in seven patients). The clinical target volume (CTV) included the entire preoperative ipsilateral hemithorax and involved nodal stations. The CTV was generally expanded by 10-15 mm beyond the planning target volume (PTV). The dose prescription was designed to cover 95% of the PTV with 54 Gy in 30 fractions. The median follow-up period was 11 months. Treatment-related toxicities were evaluated by Common Terminology Criteria for Adverse Events (CTCAE) ver. 4. One-year local control, disease-free survival, and overall survival rates were 55.7% [95% confidence interval (CI): 25.6-85.8%], 29.3% (95% CI: 5.3-53.3%), and 43.1% (95% CI: ...
We report a novel less-invasive extrapleural pneumonectomy for early-stage malignant pleural mesothelioma without rib spreading. Our approach is unique and differed from the previously reported cases, because we used one skin incision and two small intercostal incisions with videothoracoscopic viewing without rib spreading. The pleural dissection and approach to the hilum for pneumonectomy were performed through a 4- to 5-cm port incision in the sixth intercostal space. Another 4- to 5-cm port was made in the eight intercostal space through the same skin incision and was used for diaphragm resection and reconstruction. At the end of the surgery, the skin incision was enlarged to 8 cm; through which and the first port in the sixth intercostal space, the resected specimen was retrieved. Three cycles of adjuvant chemotherapy followed by radiation therapy were administered. Eleven-month follow-up showed no recurrence.. ...
Apoptosis is a special form of cell death that if non-functional may lead to diseases such as cancer. A reduction of the intracellular potassium ion (K+) content is necessary for activating enzymes important for the execution of apoptosis. Pharmacological modulation of K+ fluxes to reduce intracellular K+ in cancer cells might therefore force the cells into apoptosis and decrease tumour cell mass.. Human malignant pleural mesothelioma (MPM) is a form of cancer often caused by asbestos exposure. Although asbestos has been banned in the Western World, the incidence of MPM is expected to increase. Cisplatin is the first-line chemotherapy for MPM, but acquired resistance to the drug is a clinical problem.. This thesis is mainly based on work with the human malignant pleural mesothelioma cell line (P31 wt) and a cisplatin-resistant sub-line (P31 res). The aim was to first characterize K+ fluxes in P31 wt and P31 res cells, and then manipulate them in order to reduce intracellular K+ and induce ...
The diagnosis of MPM is always challenging because (1) MPM may appear in patients up to 30-40 years after exposure to asbestos; (2) the clinical and imaging signs of MPM are non-specific; and (3) a definitive diagnosis, which relies on histology, can sometimes be very difficult to achieve, even with the use of immunohistochemistry.5 To date, no single marker or panel of soluble biomarkers is available for a clear diagnosis of MPM.51 ,52. In the present meta-analysis our results indicated that the pooled sensitivity of serum and PF SMRPs was 0.61 and 0.79, respectively, and their specificity was 0.87 and 0.85, respectively. These data indicated that the sensitivity and specificity of SMRPs in serum and PF were not as high as expected. SMRPs might be helpful in confirming (ruling in) MPM if the results are higher than the cut-off values. Thus, positive SMRP test results suggested that invasive diagnostic steps such as medical thoracoscopy might be necessary. On the other hand, the low sensitivity ...
Read about how two FDA-approved drugs, Tesaro and Lynparza, induced death of malignant pleural mesothelioma cells in a University of Florida in vitro study.
To be considered a candidate for EPP, a patient must meet several preoperative criteria (Table 122-1). The patient must have a Karnofsky performance status of greater than 70, normal liver and renal function tests, a room air arterial Pco2 of less than 45 mm Hg, and a room air arterial Po2 of greater than 65 mm Hg. While there is no strict age limit, we are hesitant to perform EPP in patients older than 70 years of age. A pulmonary function test that reveals a forced expiratory volume in 1 second (FEV1) greater than 2 L is considered adequate for pneumonectomy. Quantitative ventilation/perfusion scan is indicated if the FEV1 is less than 2 L. The combination of ventilation/perfusion scan and preoperative FEV1 is used to predict postoperative lung function. Patients with a predicted postoperative FEV1 of greater than 0.8 are acceptable candidates for EPP. Patients with a predicted postoperative FEV1 of less than 0.8 L are considered for pleurectomy and decortication (see Chapter 121). ...
Candidate microRNAs from microarray profiling of tumor samples from 8 long (median: 53.7 months) and 8 short (median: 6.4 months) survivors following extrapleural pneumonectomy (EPP) were validated by RT-qPCR in 48 additional EPP samples. Kaplan-Meier log ranking was used to further explore the association between microRNA expression and overall survival (OS). Binary logistic regression was used to construct a microRNA signature (miR-Score) that was able to predict an OS of ≥20 months. Performance of the miR-Score was evaluated by receiver operating characteristic (ROC) curve analysis and validated in a series of 43 tumor samples from patients who underwent palliative surgery [pleurectomy/decortication (P/D)].. ...
INTRODUCTION: Malignant pleural mesothelioma (MPM) is a rare cancer that affects the thin cell wall lining of internal organs and structures. Studies have shown that patients with lung cancer have decreased pulmonary function and exercise capacity after pneumonectomy. However, to date, physical function and health-related quality of life (HRQOL) in surgically treated MPM patients have not been evaluated in detail. The aim of this study was to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D). METHODS: The subjects were 22 MPM patients (20 men and 2 women) who completed P/D between December 2013 and March 2015. Physical function was assessed using handgrip strength and knee extensor strength tests, the 6-min walk distance (6MWD), and pulmonary function tests, including forced expiratory vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). RESULTS: The ...
Most people with DMM have a brief history of exposure to asbestos; however, if they are uninformed that such exposure occurred, they may be ignorant that they are in danger. A patient with DMM an average of has one or more of the shortness of breath and symptoms: chest pain, following signs, unexplained weight reduction, exhaustion, fever, or a cough. An x-ray often suggests that the pleural tissue around the lungs has thickened as a result of development of a number of nodules or small malignant growths. Sometimes, there may be just one large development. The kinds of cells which make up the cancer might be epithelioid, combined, or sarcomatoid, when a biopsy of the cancer tissue is performed. Individuals with epithelioid cell cancers tend to survive fairly longer; these with sarcomatoid cancers usually have the shortest survival. Dig up more about the internet by browsing our cogent essay ...
The non-receptor cytoplasmic tyrosine kinase, Focal Adhesion Kinase (FAK) is known to play a key role in a variety of normal and cancer cellular functions such as survival, proliferation, migration and invasion. It is highly active and overexpressed in various cancers including Pancreatic Ductal Adenocarcinoma (PDAC) and Malignant Pleural Mesothelioma (MPM). Here, initially, we demonstrate that FAK is overexpressed in both PDAC and MPM cell lines. Then we analyze effects of two small molecule inhibitors PF-573228, and PF-431396, which are dual specificity inhibitors of FAK and proline rich tyrosine kinase 2 (PYK2), as well as VS-6063, another small molecule inhibitor that specifically inhibits FAK but not PYK2 for cell growth, motility and invasion of PDAC and MPM cell lines ...
Inclusion Criteria: - STEP 1: NEOADJUVANT - Patient must have stage I-III malignant pleural mesothelioma that is deemed resectable and must be planning to undergo pleurectomy decortication (P/D) or extrapleural pneumonectomy (EPP) - Patient must have epithelioid or biphasic histology (sarcomatoid histology is excluded); histologic diagnosis and typing of mesothelioma requires at least a core needle biopsy or surgical biopsy of the pleura via thoracoscopy and small thoracotomy; cytology only will not be regarded as sufficient for the diagnosis - Patient must have computed tomography (CT) chest/abdomen/pelvis with contrast or fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/CT scan performed within 28 days prior to step 1 registration - Patients must have non-measurable or measurable disease documented by CT or magnetic resonance imaging (MRI); the CT from a combined PET/CT may be used to document only non-measurable disease unless it is of diagnostic quality; measurable disease must ...
Pleurectomy/decortication is a common, lung-saving surgical treatment for pleural mesothelioma. Learn more about procedure, risks and success rates.
There is no widely accepted standart of care for patients with malignant pleural mesothelioma (MPM). Multimodality treatment protocol should be the standard approach in suitable patients and performed as a part of a trial: Biopsy proven MPM of non-sarcomatiod cell type, T1-3, N0-1, M0, patient fit for extrapleural pneumonectomy (EPP), neo-/adjuant chemotherapy, and radical hemithoracic irridation.. In this study we evaluated the outcome of our patients with MPM who were treated by multimodality schedule including EPP, radical hemithoracic irridation, and cisplatin-pemetrexed/gemcitabine chemotherapy regimen.. A total of 29 patients who consecutively underwent multimodality treatment schedule, 15 men, 14 women, were included. Of the patients 24 had epithelial cell type, 5 were mixed. 12 patients had stage 1 disease, 6 had II, 10 had III, 1 had IV (after surgery). Perioperative mortality (in 1 month) was 14% (4/28), mortality during multimodal therapy schedule was 18% (5/28). Patients completed ...
The study is a phase I/II prospective single cohort clinical feasibility study. 100 patients with early stage resectable malignant pleural mesothelioma will be enrolled into the study. Patients will have a baseline PET scan. Patients on the study will receive IMRT for approximately 1 week of 5 daily treatments. 1 week post-RT, they will proceed with an extrapleural pneumonectomy. If the mediastinal lymph nodes that are removed during surgery are positive for tumour cells, 3 cycles of chemotherapy, consisting of raltitrexed and cisplatin OR Pemetrexed and cisplatin, will be given 6-12 weeks post-surgery. Before and during treatment, side effects will be assessed. After treatment, follow up visits will be conducted every 1 to 2 months for the first year, and every 3 months for the second year. At each visit, a history and physical examination will be performed and ECOG performance status will be assessed. Routine tests will include CBC, liver profile, creatinine and chest x-ray. CT thorax and ...
de Perrot M, Uy K, Anraku M, Tsao MS, Darling G, Waddell TK, Pierre AF, Bezjak A, Keshavjee S, Johnston MR. Impact of lymph node metastasis on outcome after extrapleural pneumonectomy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2007 Jan; 133(1):111-6 ...
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Authors: Lachno, D. Richard , Evert, Barbara A. , Maloney, Kaia , Willis, Brian A. , Talbot, Jayne A. , Vandijck, Manu , Dean, Robert A. Article Type: Research Article Abstract: The aim of this study was to validate assays for measurement of amyloid-β (Aβ) peptides in cerebrospinal fluid (CSF) specimens according to regulatory guidance and demonstrate their utility with measurements in specimens from Alzheimers disease (AD) studies. Methods based on INNOTEST® β-AMYLOID(1-42) and prototype INNOTEST® β-AMYLOID(1-40) ELISA kits were developed involving pre-analytical sample treatment with Tween-20 for reliable analyte recovery. Validation parameters were evaluated by repeated testing of CSF pools collected and stored in the same manner as clinical specimens. Intra- and inter-assay coefficients of variation were ≤11% and relative accuracy was within ± 10% for …both analytes. Dilutional linearity was demonstrated for both analytes from a spiked CSF pool, but not from a non-spiked native ...
Authors: Lachno, D. Richard , Evert, Barbara A. , Vanderstichele, Hugo , Robertson, Michael , DeMattos, Ronald B. , Konrad, Robert J. , Talbot, Jayne A. , Racke, Margaret M. , Dean, Robert A. Article Type: Research Article Abstract: The aim of this study was to validate new assays for measurement of amyloid-β (Aβ) peptides in cerebrospinal fluid (CSF) and plasma specimens in clinical studies of solanezumab according to current regulatory recommendations. Four assays based on the INNOTEST® β-AMYLOID(1-42) and prototype INNOTEST β-AMYLOID(1-40) kits were developed and validated. To render these assays solanezumab-tolerant, excess drug was added to calibrators, quality control, and test samples via a 2-fold dilution with kit diluent. Validation parameters were evaluated by repeated testing of human CSF and EDTA-plasma pools containing solanezumab. Calibration curve correlation coefficients for the four assays were ≥0.9985. …Intra- and inter-assay coefficients of variation for Aβ1-40 and ...
Aging of the Brain and Alzheimers Disease, Volume 70 (Progress in Brain Research) English | ISBN: 0444807934 | edition 1986 | PDF | 543 pages | 39,6 mb This book contains the proceedings of
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TY - JOUR. T1 - Evaluation of soluble mesothelin-related peptide as a diagnostic marker of malignant pleural mesothelioma effusions. T2 - its contribution to cytology.. AU - Canessa, Pier Aldo. AU - Franceschini, Maria Cristiana. AU - Ferro, Paola. AU - Battolla, Enrico. AU - Dessanti, Paolo. AU - Manta, Carmen. AU - Sivori, Massimiliano. AU - Pezzi, Riccardo. AU - Fontana, Vincenzo. AU - Fedeli, Franco. AU - Pistillo, Maria Pia. AU - Roncella, Silvio. PY - 2013/1. Y1 - 2013/1. N2 - Soluble mesothelin-related peptide (SMRP) is regarded as an FDA approved biomarker for the diagnosis and monitoring of pleural malignant mesothelioma (MPM). We detected the SMRP levels in pleural effusions (PE) by means of an ELISA and analyzed their diagnostic relevance to differentiate MPM from benign pathology and from non-MPM pleural metastasis. Comparison with cytology in MPM-PE was also performed. We found that SMRP detection in MPM-PE can help the diagnosis of MPM and provide additional diagnostic value to ...
Malignant pleural mesothelioma (MPM), an aggressive malignant tumor of mesothelial origin associated with asbestos exposure, shows a limited response to conventional chemotherapy and radiotherapy. Therefore, the overall survival of MPM patients remains very poor. Progress in the development of therapeutic strategies for MPM has been limited. We recently reported that the calpain inhibitor, calpeptin exerted inhibitory effects on pulmonary fibrosis by inhibiting the proliferation of lung fibroblasts. In the present study, we examined the preventive effects of calpeptin on the cell growth of MPM, the origin of which is mesenchymal cells, similar to lung fibroblasts. Calpeptin inhibited the proliferation of MPM cells, but not mesothelial cells. It also prevented 1) the expression of angiopoietin (Ang)1 and Tie2 mRNA in MPM cells, but not mesothelial cells and 2) the Ang1induced proliferation of MPM cells through an NFkB dependent pathway, which may be the mechanism underlying the preventive effects of
TY - JOUR. T1 - Survival results in biphasic malignant pleural mesothelioma patients: A multicentric analysis. AU - Lococo, Filippo. AU - Torricelli, Federica. AU - Lang-Lazdunski, Loic. AU - Veronesi, Giulia. AU - Rena, Ottavio. AU - Paci, Massimiliano. AU - Casadio, Caterina. AU - Piana, Simonetta. AU - Novellis, Pierluigi. AU - Di Stefano, Teresa Severina. AU - Ciarrocchi, Alessia. AU - Billè, Andrea. PY - 2019/9/9. Y1 - 2019/9/9. N2 - Objective: The best strategy of care for biphasic malignant pleural mesothelioma (Biph-MPM) is controversial. In this study, a large dataset of Biph-MPM cases was reviewed to identify prognostic factors and to evaluate the role of a multimodal approach, including cancer-directed surgery. Methods: A total of 213 patients with Biph-MPM treated at 4 tertiary centers who experienced MPM from January 2009 to December 2016 were selected, and clinical, pathologic, and surgical information was retrieved. A Cox regression model was used to identify predictors of ...
RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium, gemcitabine, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether giving pemetrexed disodium with gemcitabine is more effective than giving pemetrexed disodium with carboplatin in treating malignant pleural mesothelioma.. PURPOSE: This randomized phase II trial is studying pemetrexed disodium with gemcitabine and pemetrexed disodium with carboplatin to see how well the combinations work compared to historical controls in treating patients with advanced malignant pleural mesothelioma. ...
Inclusion Criteria: - Patients >18 years affected by malignant pleural mesothelioma previously treated with no more than one systemic therapeutic regimen - Histologically or cytological confirmed malignant pleural mesothelioma of any of the following subtype: epithelial, sarcomatous, mixed - Prior intrapleural cytotoxic agents including bleomycin not considered systemic chemotherapy - ECOG Performance status 0 - 2 - Adequate baseline bone marrow, hepatic and renal function, defined as follows: - Neutrophils > 1.5 x 10^9/L and platelets > 100 x 10^9/L - Bilirubin < 1.5 x ULN - AST and/or ALT < 2.5 x ULN in absence of liver metastasis - AST and/or ALT < 5 x ULN in presence of liver metastasis - Serum creatinine < 1.5 x ULN - Absence of any conditions in which hypervolemia and its consequences (e.g. increased stroke volume, elevated blood pressure) or haemodilution could represent a risk for the patient (take as reference "Technical data sheet human albumin" specifically used in Pharmacy Department ...
Liposomal doxorubicin consists on doxorubicin encapsulated in liposomes that are composed of phosphatidylcholine and cholesterol. Liposomal doxorubicin can extravasate into tumors with abnormal vascular endothelium but may not penetrate normal tissues lowering its toxicity and increasing its efficiency. Combining Liposomal doxorubicin with cisplatin could be an effective new chemotherapy treatment for malignant pleural mesothelioma .. Hypothesis:. Liposomal doxorubicin combined with cisplatin could increase response rates to chemotherapy, progression free survival and overall survival in patients with malignant pleural mesothelioma. ...
Treatment of Malignant mesothelioma is a rare cancer that occurs in the thin layer of tissue that covers the majority of your internal organs. Doctors divide mesothelioma into different categories based on what part of the mesothelium is affected by cancer. Mesothelioma that occurs in the tissue that surrounds the lung is called pleural mesothelioma and is the most common form. Mesothelioma that occurs in the tissue in your abdomen is called peritoneal mesothelioma and accounts for 10 percent to 20 percent of all mesotheliomas. In rare cases, mesothelioma can also occur in the lining around the heart, and in the lining around the testicles, Between 2,000 and 3,000 people are diagnosed with mesothelioma in the United States each year. Men are more likely to develop mesothelioma than are women. Its more common in older adults - most people with mesothelioma are 65 and older - though mesothelioma can be diagnosed at any age, Mesothelioma is closely linked to exposure to asbestos - a natural fiber that was
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Our results suggest that CK2α is over-expressed and positively regulates Hh/Gli1 signaling in human malignant pleura mesothelioma. This is supported by several lines of evidence. First, broadly aberrant over-expression of CK2 was demonstrated in most of the primary mesothelioma samples and cell lines we tested. Second, we found a statistically mild correlation between CK2 and Gli1 expression both at the mRNA and protein levels. Third, in experimental studies of mesothelioma cell lines, CK2α inhibition by siRNA or small-molecular inhibitor resulted in down-regulation of Gli1 expression and transcriptional activity. Finally, forced over-expression of CK2α led to Gli1 transcriptional activation.. To date, there is no evidence for the expression status of CK2 in mesothelioma, although CK2 reportedly affects cell growth in several types of tumor. Our study shows the broad over-expression of CK2α for the first time. Our findings suggest that CK2 may play an important role in mesothelioma ...
Asbestos Cancer Pleural mesothelioma is cancer of the lining of the lungs. It is not the same as lung cancer, but is sometimes referred to as asbestos lung cancer. Pleural mesothelioma is the most common type of mesothelioma, accounting for about 75% to 90% of mesothelioma cases. Most patients do not notice or recognize symptoms until 20 to 50 years after asbestos exposure, and may at first believe that they have another less serious illness. Pleural mesothelioma kills most victims within a year of diagnosis, but very early detection can greatly increase your life expectancy.. Pleural mesothelioma is a progressively debilitating and very painful form of cancer. It is caused by asbestos exposure. The majority of victims were exposed in the workplace, but exposure can occur in the home, at school, or in other settings.. The Pleura. The pleura is the mesothelium which surrounds the lungs. It protects and lubricates the lungs, helping them to function properly. It is made up of two layers:. ...
Breathlessness is the most common symptom of pleural mesothelioma. In the early stages of pleural mesothelioma controlling the pleural fluid build-up around the lungs and having surgery will improve breathlessness. The level of improvement will depend on how healthy your lungs were before you developed pleural mesothelioma and the level of lung function after surgery.. During the process of diagnosing pleural mesothelioma, fluid build-up will have been drained off, and further accumulation of fluid may be prevented by pleurodesis. For more information on pleurodsis click here and see the Pleurodesis section under General tests.. Although living with breathlessness can be difficult and can cause distress, there are surgical and non-surgical ways to prevent or reduce its impact on your life.. Improving breathlessness with surgery. Video-assisted thoracoscopic surgery (VATS) and talc pleurodesis. If you were diagnosed with pleural mesothelioma after a CT-guided core biopsy and the symptoms of ...
This report is an analysis of the medical records of 83 patients registered between 1960 and 1980 at Helsinki University Central Hospital as having malignant pleural mesothelioma. Sixty five of 83 patients had histologically confirmed malignant mesothelioma, and are the focus of this analysis. The remaining 18 (22%) patients were excluded because malignant mesothelioma was only confirmed cytologically, or because the primary tumor was not a mesothelioma. The ratio of men to women was 2:1.30 of 65 (46%) patients were not known or not likely to have been exposed to asbestos. The main symptoms at presentation were dyspnea, cough, chest pain, fatigue and weight loss. The median survival from diagnosis was 12 months, and from the onset of symptoms 18 months. Clinical stage and performance status were significant prognostic factors. Hematogenous metastases were present at autopsy in most cases. Disease and performance status therefore need to be well established and documented in clinical trials ...
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The two surgical alternatives for mesothelioma are pleurectomy/decortication, above-referenced and a more radical procedure known as an extrapleural pneumonectomy or EPP. Using EPP procedures, surgeons remove the entire diseased lung, the lining of the lung, part of the membrane covering the heart and part of the diaphragm.. Extrapleural pneumonectomy was considered the standard surgery procedure for mesothelioma. The new research presented in the medical journal of the International Association for the Study of Lung Cancer concludes that patients who underwent a pleurectomy/decortication had better results than those who underwent more extensive surgery, based on a recent analysis. The researchers studied about 75 mesothelioma patients who underwent either of the two surgical procedures between January 2008 and June 2011.. The researchers observed that 4.5 percent of 22 patients who underwent an extrapleural pneumonectomy, the radical procedure, died within a month compared to none in the group ...
As the second installment in a series of webcasts aimed at educating physicians and the general public about new, innovative surgical procedures, surgeons at Brigham and Womens Hospital (BWH) will demonstrate a type of cancer surgery that generally extends the lives of patients stricken by mesothelioma, an aggressive form of cancer most often associated with exposure to asbestos. The webcast will take place on May 1 at 4:30 P.M. EST and can be accessed by going to www.brighamandwomens.org/surgerywebcast.. The procedure is known as extrapleural pneumonectomy, and is performed on patients suffering from malignant pleural mesothelioma, a form of cancer that occurs in the cells that line the chest cavity. The operation consists of the surgeon removing the thin membrane of tissue that covers the lungs and the heart, as well as a lung and the diaphragmatic muscle. Although not experimental, the surgery is not widely done due to its complexity, and the relative rarity of the type of cancer the ...
All patients with pleural mesothelioma is diagnosed should get some kind of treatment that can extend the useful life and the survival of the State-of-the-art treatments that are available, although it is not a cure for pleural mesothelioma, as is done with most of the cancers. Treatment of pleural mesothelioma include surgery, chemotherapy, and for the radius of the care and treatment option depends on the number, such as pleural mesothelioma has spread to other organs, at the age of the patient and the patients general health. ...
12 NCCN Guidelines for Patients ® : Malignant Pleural Mesothelioma, Version 1.2016 2 Testing for mesothelioma 13 What are the symptoms? 13 How is mesothelioma found? 16 Review ...
A virus that causes leukemia in gibbon apes may have the power to help fight malignant mesothelioma in people.. Gibbon ape leukemia virus (GALV) has been tested for years as a viral vector, a carrier of therapeutic genetic information, in the treatment of various human illnesses, including cancer. A new study in Japan compared GALV with a leukemia virus derived from mice to see which carrier communicated most efficiently with mesothelioma cells. While both types of viruses replicated in most of the mesothelioma cell lines tested, the mouse-derived virus was not effective in a mesothelioma cell line called ACC-MESO-1. In this cell line, only the GALV spread efficiently both in culture and in mice that had been given human mesothelioma xenografts. GALV carrying a "prodrug activator gene" (which triggers expression of a suicide gene in infected cells) efficiently killed ACC-MESO-1 mesothelioma cells. The result was "significant inhibition" of mesothelioma tumor growth in the mice. Further testing ...
... - Mesothelioma is a rare and aggressive tumor associated with exposure to asbestos by inhalation or oral
Objectives: Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. microRNA-34b/c (miR-34b/c), which plays an important role in the pathogenesis of MPM, is frequently downregulated by DNA methylation in approximately 90% of MPM cases. In this study, we estimated the degree of miR-34b/c methylation in serum-circulating DNA using a digital methylation specific PCR assay (MSP). Materials and methods: A real-time MSP assay was performed using the SYBR Green method. The melting temperature (Tm) of each PCR product was examined using a melting curve analysis. For a digital MSP assay, 40 wells were analyzed per sample. A total of 110 serum samples from 48 MPM cases, 21 benign asbestos pleurisy (BAP) cases, and 41 healthy volunteers (HVs) were examined. Results: Positive range of Tm value for miR-34b/c methylation was defined as 77.71-78.79 degrees C which was the mean 3 standard deviations of 40 wells of a positive control. The number of miR-34b/c methylated wells was ...
Malignant pleural mesothelioma is a fatal neoplasm related to asbestos exposure. We investigated the effects of pleurectomy/decortication (P/D), hyperthermic pleural lavage with povidone-iodine and adjuvant chemotherapy in patients with malignant pleural mesothelioma. Observational prospective stud...
Send Orders for Reprints to 10 The Open Cardiovascular and Thoracic Surgery Journal, 2013, 6, Progress in Radical Surgery for Malignant Pleural Mesothelioma Leonardo Politi
We have recently proposed to reclassify the pleomorphic subtype of epithelioid malignant pleural mesothelioma (MPM) as nonepithelioid (biphasic/sarcomatoid) histology because of its similarly poor prognosis. We sought to investigate whether preoperative maximum standardized uptake value (SUVmax) on...
Immunotherapy is the most promising therapeutic approach against malignant pleural mesothelioma (MPM). Despite technological progress, the number of targetable antigens or specific antibodies is limited, thus hindering the full potential of recent therapeutic interventions. All possibilities of finding new targeting molecules must be exploited. The specificity of targeting is guaranteed by the use of monoclonal antibodies, while fully human antibodies are preferred, as they are functional and generate no neutralizing antibodies. The aim of this review is to appraise the latest advances in screening methods dedicated to the identification and harnessing of fully human antibodies. The scope of identifying useful molecules proceeds along two avenues, i.e., through the antigen-first or binding-first approaches. The first relies on screening human antibody libraries or plasma from immunized transgenic mice or humans to isolate binders to specific antigens. The latter takes advantage of specific binding to
Protocol for the Examination of Specimens From Patients With Malignant Pleural Mesothelioma Based on AJCC/UICC TNM, 7th edition Protocol web posting date: February 1, 2011 Procedures Resection Authors
Despite innumerable trials of surgery, radiotherapy, and countless chemotherapeutic drugs, it is unclear whether any intervention has had a significant impact on more than a few highly selected patients with malignant pleural mesothelioma. Because mo