Abstract An analogue of primaquine, N1-(3-acetyl-4-5-dihydro-2-furanyl)-N4-(6-methoxy-8-quinolinyl) 1, 4-pentanediamine, CDRI Code 80/53), has been evaluated for anti-relapse activity against sporozoite induced Plasmodium cynomolgi B infection in rhesus monkeys. The compound has shown 100% curative anti-relapse activity at 1.25 mg/kg × 7 day dose schedule, thereby giving a primaquine index of 0.8. The compound is currently under Phase-I clinical trials.

Demonstration of a persisting exo-erythrocytic cycle in plasmodium cynomolgi and its bearing on the reproduction of relapses / H. E. Shortt and P. C. C. ...

After orangutans in Indonesia were reported as infected with Plasmodium cynomolgi and P. vivax, we conducted phylogenetic analyses of small subunit ribosomal RNA gene sequences of Plasmodium spp. We found that these orangutans are not hosts of P. cynomolgi and P. vivax. Analysis of >or=1 genes is needed to identify Plasmodium spp. infecting orangutans ...

This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 September-5 October 2019 and includes updates on Ebola virus disease, extensively drug-resistant Klebsiella pneumoniae, mass gathering monitoring (Japan, Rugby World Cup 2019), Middle East respiratory syndrome coronavirus, Plasmodium cynomolgi infection, poliomyelitis, West Nile virus, and yellow fever. ...

This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 September-5 October 2019 and includes updates on Ebola virus disease, extensively drug-resistant Klebsiella pneumoniae, mass gathering monitoring (Japan, Rugby World Cup 2019), Middle East respiratory syndrome coronavirus, Plasmodium cynomolgi infection, poliomyelitis, West Nile virus, and yellow fever. ...

Human infections with Plasmodium knowlesi, a malaria parasite of long-tailed and pig-tailed macaques, were thought to be extremely rare until a large focus of human infections were reported in the Kapit division of Sarawak, Malaysian Borneo in 2004. Macaques in the Kapit division also harbour P. cynomolgi, P. inui, P. simiovale, P. coatneyi, and P. fieldi. Under experimental conditions P. cynomolgi and P. inui can infect humans, and there has been one previous case of a naturally-acquired human infection with P. cynomolgi in Peninsular Malaysia, and recent cases of P. cynomolgi in asymptomatic individuals in Cambodia. The aim of the study was to determine whether human infections with P. cynomolgi and P. inui also occur in Sarawak. DNA extracted from blood samples obtained from malaria patients at Kapit Hospital were screened with nested PCR assays using species-specific primers directed at P. knowlesi, P. cynomolgi, P. inui, P. coatneyi and P. fieldi. The screening exercise indicated the ...

|jats:title|Key Points|/jats:title| |jats:p|Zoonotic P cynomolgi switches red cell tropism for reticulocytes expressing Trf1 (CD71+) and DARC (CD234+). In the human host, P cynomolgi displays an almost identical rheopathobiology to P vivax.|/jats:p|

Preventing relapses of Plasmodium vivax malaria through a radical cure depends on use of the 8-aminoquinoline primaquine, which is associated with safety and compliance issues. For future malaria eradication strategies, new, safer radical curative compounds that efficiently kill dormant liver stages (hypnozoites) will be essential. A new compound with potential radical cure activity was identified using a low-throughput assay of in vitro-cultured hypnozoite forms of Plasmodium cynomolgi (an excellent and accessible model for Plasmodium vivax). In this assay, primary rhesus hepatocytes are infected with P. cynomolgi sporozoites, and exoerythrocytic development is monitored in the presence of compounds. Liver stage cultures are fixed after 6 days and stained with anti-Hsp70 antibodies, and the relative proportions of small (hypnozoite) and large (schizont) forms relative to the untreated controls are determined. This assay was used to screen a series of 18 known antimalarials and 14 new ...

1B9W: The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate.

Abstract In a genetically selected strain of the malaria vector Anopheles gambiae, most species of Plasmodium parasites are surrounded by melanized capsules and killed in the wall of the mosquito midgut. Genetic studies demonstrate a significant association between the refractory response to Plasmodium cynomolgi B strain and the Est A allele at an autosomal esterase locus. Increased susceptibility to parasites is associated with an alternate Est C allele. Lines selected to be homozygous for the Est A and Est C alleles show enhanced levels of refractoriness and susceptibility when compared to the unselected parental stock. Expression of the refractory phenotype is reduced much more than the susceptible phenotype at high parasite density, suggesting that refractoriness may be due to a positive effector.

ID K6VAP6_9APIC Unreviewed; 638 AA. AC K6VAP6; DT 09-JAN-2013, integrated into UniProtKB/TrEMBL. DT 09-JAN-2013, sequence version 1. DT 25-OCT-2017, entry version 22. DE RecName: Full=Glycerol-3-phosphate dehydrogenase {ECO:0000256,RuleBase:RU361217}; DE EC=1.1.5.3 {ECO:0000256,RuleBase:RU361217}; DE Flags: Fragment; GN ORFNames=PCYB_084280 {ECO:0000313,EMBL:GAB66267.1}; OS Plasmodium cynomolgi strain B. OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium). OX NCBI_TaxID=1120755 {ECO:0000313,EMBL:GAB66267.1, ECO:0000313,Proteomes:UP000006319}; RN [1] {ECO:0000313,EMBL:GAB66267.1, ECO:0000313,Proteomes:UP000006319} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=B {ECO:0000313,EMBL:GAB66267.1, RC ECO:0000313,Proteomes:UP000006319}; RX PubMed=22863735; DOI=10.1038/ng.2375; RA Tachibana S., Sullivan S.A., Kawai S., Nakamura S., Kim H.R., Goto N., RA Arisue N., Palacpac N.M.Q., Honma H., Yagi M., Tougan T., Katakai Y., RA ...

Demonstration of a persisting exo-erythrocytic cycle in Plasmodium cynomolgi and its bearing on the production of relapses Public Health Classics ...

Plasmodium vivax uses multiple ligand-receptor interactions for preferential invasion of human reticulocytes. Several of these ligands have been identified by in silico approaches based on the role displayed by their orthologs in other Plasmodium species during initial adhesion or invasion. However, the cell adhesion role of proteins that are exclusive to species that specifically invade reticulocytes (as P. vivax and P. cynomolgi) has not been evaluated to date. This study aimed to characterise an antigen shared between Plasmodium species that preferentially infect reticulocytes with a focus on assessing its binding activity to target cells. An in silico analysis was performed using P. vivax proteome data to identify and characterise one antigen shared between P. vivax and P. cynomolgi. This led to identification of the pvrbsa gene present in the P. vivax VCG-I strain genome. This gene is transcribed in mature schizonts and encodes a protein located on the parasite surface.

Introduction: Gestational malaria is a major public health problem because it is a threat to pregnant women and their children. As Kisangani is a stable malaria transmission area and there is a paucity of data on the status of gestational malaria in our settings, we have found it appropriate to determine the prevalence of gestational malaria and its determinants in Kisangani City. Methods: We conducted a cross-sectional analytical study in Kisangani from January 1 to September 30, 2017. Our population study consisted of 1248 parturients recruited at delivery. We made the thick drop in peripheral blood from parturients at the admission and at the level of placental impressions after delivery. Results: The average age of the respondents was 25.3971 ± 6.2452 years; the overall prevalence of gestational malaria was 27.56% including 12.66% peripheral parasitaemia, 12.34% placental parasitaemia and 2.56% parasitaemia level and placental and peripheral blood impressions. Youngest age ≤ 18 years [OR (95% CI)

The first person to see P. knowlesi was probably the Italian Giuseppe Franchini in 1927 when he was examining the blood of Macaca fascicularis and he noted that it differed from Plasmodium cynomolgi and Plasmodium inui.[6] It was later seen by Campbell[ambiguous] in 1931 in a long-tailed macaque imported from Singapore to the Calcutta School of Tropical Medicine and Hygiene in India. Campbell was interested in another disease, kala azar, and was working under Napier.[ambiguous] Napier inoculated the strain into three monkeys, one of which was a rhesus macaque (Macaca mulatta), which developed a fulminating infection. Knowing that the Protozoological Department were looking for a monkey malaria strain, they handed the original infected monkey to Biraj Mohan Das Gupta, who was the assistant of Robert Knowles. Dr Das Gupta maintained the species by serial passage in monkeys until Dr Knowles returned from leave. In 1932, Knowles and Das Gupta described the species in detail for the first time and ...

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This chapter describes the internal administration and foreign relations of the Mauryan empire under the reign of Aśoka. It explains that the establishment of the Mauryan state ushered in a new form of government, that of a centralised empire. Under this regime, the king had the central authority, and he not only defended social usage according to the traditional concept of kingship, but could also make his own laws. It was because of this increased power of the king that the Mauryan centralised monarchy became a paternal despotism under Aśoka. This chapter describes the Mauryan states relationship with Kalinga and Ceylon. It suggests that Aśokas relationship with Ceylon was not purely political, because though there may have been a considerable exchange of missions, Ceylon remained an independent kingdom.

Nothing is assignable to all other types, but has no instances. A reference to a member of an expression of type Nothing is always an error, since there can never be a receiving instance. Nothing is considered to belong to the module ceylon.language. However, it cannot be defined within the language.. Because of the restrictions imposed by Ceylons mixin inheritance model:. ...

It is not just that the people cant freely return to their homes after many months that the war is over, or that the nutritional needs of children are not been met at all, but the fact that most of such camps are plainly flooded and children and adults alike are forced to live in water and side by side to their own excrements. People are dying right now on contagious diseases that they would probably never catch outside. ...

Department of Defence. Health Portal. The ADF Health and Wellbeing Portal is a single point of access for ADF members to information on health, mental health and rehabilitation support and services from within Defence, and from other government departments and community organisations.​

CEYLON, Sask. - Farmer Ken Catherwoods wife died of cancer 17 years ago, leaving him to raise Kristin, 10, Janelle, 8, and Shawn, 2. The

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One knows about the place Ceylon which is now known as Sri Lanka. Tea production in this country is rather impressive. This is so on account of the excellent terrain and temperature of Sri Lanka as it is an ideal place to grow tea. One gets them in three varieties - black, green, and white. Black Ceylon tea indeed the most common form. Green Ceylon tea has a more pungent, nutty flavor as compared to black and contains a lot of antioxidants as these tea leaves are unfermented.. White Ceylon tea is very expensive and is available in its rarest form with a sweet and pleasant flavor. It is known for its high polyphenolic content. It contains several flavonoids, antioxidants, and polyphenolic compounds which are useful for various ailments and afflictions and for topical applications.. ...

Buy pure Ceylon tea online directly from Sri Lanka. We offer 100% premium quality Ceylon Tea with a wide range of black, green, white, flavored teas and herbal infusions. Browse through our world renowned brands Mlesna, Dilmah, Zesta and Fadna. Worldwide shipping available.

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THEGREATREOPENING KATE AND LUCS CAFE WILL BE OPEN THIS TEUSDAY 8:30AM WHO CAN MAKE IT DOWN AND SUPPORT? 213 BURNAGE ROAD, MANCHESTER LATEST VIDEO FROM THIS STORY: WEBSITE: https://the-great-reopening.com/​ SOCIAL MEDIA TELEG…

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Are You Confident of the Diagnosis? What you should be alert for in the history Hemangiomas are benign vascular neoplasms. They are both the most common vascular tumor and the most common tumor of infancy. Classically, a parent will present with an infant who appeared normal at birth but subsequently developed a cutaneous lesion within…. ...

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Finden Sie alle Bücher von Knighton, William LL D. - The History of Ceylon from the Earliest Period to the Present Time, with an Appendix, Containing an Account of Its Present Condition. Bei der Büchersuchmaschine eurobuch.com können Sie antiquarische und Neubücher VERGLEICHEN UND SOFORT zum Bestpreis bestellen. 1241452520

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Financial Reports of Ceylon Cold Stores PLC, Sri Lankas leading food & beverage manufacturing company and the producer of Elephant House branded products

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original description Pillai, T. G. (1970). Studies on a collection of Spirorbids from Ceylon, together with a critical review and revision of Spirorbid systematics, and an account of their phylogeny and zoogeography. Ceylon Journal of Science (Biological Sciences). 8(2): 100-172. [details] ...

When I first went to Afghanistan in 1997, as the UNICEF Resident Project Officer in Jalalabad, the Taliban refused to look at me, as I happened to belong to the female gender. At meetings, which were all male events, they would look away from me with an expression of total disgust and would keep their heads turned away from me, when speaking to me. They clearly indicated that meeting with a woman was abhorrent to them. One Mullah even went to the extent of covering his own face when he had to pass by me. I found this utterly amusing and did not let it bother me.. After a couple of months of this icy reception, which I considered to be a farcical comedy, they gradually thawed and even shook my hand and became friendly. The Mayor of Jalalabad, who earlier covered his face, became particularly friendly and had many conversations with me, in English, declaring that he did not oppose girls education. I learned that he was educated to degree level. I said to my staff that I thought that perhaps the ...

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Prof Anton Jayasuriya treated more than 2 ½ million patients free of charge and trained more than 40,000 doctors in Complementary Medicines.

original description Pocock, R. I. (1892). Report upon two collections of Myriopoda sent from Ceylon by Mr. E.E. Green, and from various parts of southern India by Mr. Edgar Thurston, of the Government Central Museum, Madras. Journal of the Bombay Natural History Society, 7: 131-174 ...

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Walking into the Sri Lanka Broadcasting Corporation (SLBC) buildings at Torrington Square, one would immediately feel the historical value of the place, but most people would not know just how valuable it is. Our SLBC is Asias first broadcasting corporation. Radio Ceylon started in Sri Lanka then Ceylon, paving the way for many other radio stations that later came to be celebrated around the world, inspiring countries such as Hong Kong, Korea, India and Singapore to enter the world of wireless media.. DG of SLBC Samantha Weliweriya said that there was even speculation that the SLBC is the worlds second radio station. Even if such speculation is not true, he said it is an indication of the importance of Radio Ceylon in the world arena. Radio Ceylon definitely becomes the 30th station in the world, in a line dominated by mostly American and British radio stations, bringing immense pride to Sri Lanka.. And thats not all, there is a hidden past behind the place now occupied by the radio station. ...

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Page 2 - And yet on the other hand, unless wariness be used, as good almost kill a man as kill a good book: who kills a man kills a reasonable creature, Gods image; but he who destroys a good book, kills reason itself, kills the image of God, as it were, in the eye. Many a man lives a burden to the earth; but a good book is the precious lifeblood of a master spirit, embalmed and treasured up on purpose to a life beyond life. ...

Cala*man`der wood (?). A valuable furniture wood from India and Ceylon, of a hazel-brown color, with black stripes, very hard in texture. It is a ...

COLOMBO, LANKAPUVATH) -Price of a loaf of bread will be increased by Rs. 5 from midnight today (03), due to increase of the flour price, the All Ceylon Bakery Owners Association (ACBOA) said.. ...

Amidst the social distancing measures and meeting restrictions due to the COVID-19 pandemic Standard Chartered Bank (SCB) and Ceylon Bank Employees Union entered into a Collective Agreement for 2021-2023. Channa Dissanayake, President of CBEU, hailed the spirit of Standard Chartered Bank management coming forward to revise the terms and conditions of employment of their