Abstract: In the present study, it was envisaged to prepare three polyherbal formulations (F1, F2 and F3) containing leaves of Solanum xanthocarpum and Andrographis paniculata, rhizomes of Curcuma longa and stem of Tinospora cordifolia in varying ratio and evaluating the polyherbal formulations for the antipyretic and antinociceptive activities. The antipyretic activity of methanol extracts (MF1, MF2 and MF3) and aqueous extracts (AF1, AF2 and AF3) of polyherbal formulation were studied in Brewer s yeast induced pyrexia in mice. The antinociceptive activity of methanol and aqueous extracts of polyherbal formulation were studied using Eddy s hot plate method and tail flick method in mice. The polyherbal formulation of all extracts showed significant reduction in the elevated body temperature of rat which was compared with standard paracetamol. The extract of polyherbal formulation produced significant increase in the reaction time by Eddy s hot plate method and tail flick method in mice which was ...
Formulations restrain 2 or more than 2 herbs are called polyherbal formulation. Drug formulation in Ayurveda is based on 2 principles: Use as a single drug and use of more than one drug. The last is known as polyherbal formulation. The idea of polyherbalism is peculiar to Ayurveda even though it is tricky to explain in term of modern parameters. The Ayurvedic literature Sarangdhar Samhita tinted the idea of polyherbalism to attain greater therapeutic efficacy. Polyherbal formulation has been used all around the earth due to its medicinal and therapeutic application. It has also recognized as polyherbal therapy or herb-herb combination. The active phytochemical constituents of individual plants are inadequate to attain the desirable therapeutic effects. When polyherbal and herbo-mineral formulations combining the multiple herbs in a meticulous ratio, it will give an enhanced therapeutic effect and decrease the toxicity. The active constituents used from individual plant are inadequate to provide ...
Many traditional systems of medicines employ herbal drugs for the hepatoprotection. Aim of the study was designed to evaluate the hepatoprotective potential of polyherbal formulation against alcohol induced hepatotoxicity in wistar albino rats. Group I animals were treated with 1% CMC for 18 days. Group II, III and IV animals were treated with 1% CMC, polyherbal formulation 180mg/kg/day and silymarin 100mg/kg/day respectively for 18 days and then orally administration with ethanol 3.76 g/kg/day simultaneously for 18 days. After 24 hours of last dosing, the blood was obtained through retro-orbital plexus under light anaesthesia and the animals were sacrificed. Hepatoprotective potential was assessed by various biochemical parameters such as AST, ALT, ALP, LDH, bilirubin, cholesterol, TG and thiopentone sodium induced sleep time. Group III rats showed significant (p,0.01) decrease in AST, ALT, ALP, LDH, bilirubin, cholesterol, TG, liver weight(wt.) and relative liver wt. levels while significant ...
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Determination of volatile plant compounds in field ambient air is important to understand chemical communication between plants and insects and will aid the development of semiochemicals from plants for pest control. In this study, a thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) method was developed to measure ultra-trace levels of volatile plant compounds in field ambient air. The desorption parameters of TD, including sorbent tube material, tube desorption temperature, desorption time, and cold trap temperature, were selected and optimized. In GC-MS analysis, the selected ion monitoring mode was used for enhanced sensitivity and selectivity. This method was sufficiently sensitive to detect part-per-trillion levels of volatile plant compounds in field ambient air. Laboratory and field evaluation revealed that the method presented high precision and accuracy. Field studies indicated that the background odor of tea plantations contained some common volatile plant compounds, ...
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As the first biological and phytochemical study of M. inconstrictum, we evaluated the anti-oxidant and anti-malarial activities of n-hexane, chloroform, methanolic extracts with different polarities, and the most potent VLC fractions of the bulbs of M. inconstrictum. Furthermore, the chemical components of the liquid essential oil, the potent anti-oxidant fractions, and the strongest fraction in the anti-malarial assay were identified by the GC-MS. Furthermore, other preliminary phytochemical tests were performed for confirmation of the existence of several structural groups.. According to obtained results (Table 1), chloroform extract with RC50 value of 0.046 ± 0.005 mg/mL was the most potent anti-oxidant extract and methanolic (RC50 = 0.028 ± 0.002 mg/mL), 80% ethyl acetate/n-hexane (RC50: 0.034 ± 0.005 mg/mL), and 100% ethyl acetate/n-hexane (RC50 = 0.038 ± 0.007 mg/mL) VLC fractions of chloroform extract were the strongest fractions, in the order of their appearance. In comparison, ...
The present study was aimed to evaluate the anti diabetic activity of polyherbal formulation containing some bitter plant constituents like neem, methi, karela fruit, amla , jamun seeds, kavat fruit in
Conclusion and Recommendation: In general the antimicrobial activity of the plant observed here support the tradition therapeutic claim of the society. Further study should be conducted in further evaluating its antimicrobial effectiveness and also purification of the active chemical constituents that could be responsible for its biological activity.. Key words: Antibacterial activity, phytochemical screening, disc diffusion, broth dilution, Dichrocepala integrifolia ...
Ashish, Soni, S.J. Gupta, Amit Kumar, Y.B. Tripathi (2014) Estimation of total phenolic and flavonoid content of polyherbal formulation dashang lepa. [Publication] Full text not available from this repository ...
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TY - JOUR. T1 - Therapeutic properties of DNA-based fibroblast and dendritic cell vaccines in mice with squamous carcinoma. AU - O-Sullivan, Insug. AU - Kim, Tae Sung. AU - Chopra, Amla. AU - Cohen, Edward P.. PY - 2006/3. Y1 - 2006/3. N2 - Background: Dendritic cells (DC) express class I/II MHC-determinants and co-stimulatory molecules required for T cell activation. In a mouse model of squamous cell carcinoma (SCC), we compared the immunogenic properties of allogeneic DNA-based fibroblast vaccines, which are taken up and processed by DC of the host, and syngeneic DNA-based DC vaccines, which present antigens directly. The incentive was the important practical advantages of using fibroblasts rather than DC in generating vaccines for the immunotherapy of SCC. Materials and Methods: The fibroblast vaccine was prepared by transfer of genomic DNA-fragments (25 kb) from relatively small numbers (107=64 mm3 tumor) of SCCVII/SF cells into LM cells, a mouse fibroblast cell line (H-2k). SCCVII/SF cells ...
ClinicalTrials.gov summary of Assessment of VAC-3S Therapeutic Properties When Combined With Standard ART in the Course of HIV-1 Infection
Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing these stumbling blocks either by enhancing the solubilizing capacity or its potentiating ability to pass through the biological membranes and it also protects the active herbal components from degradation. Hence, this phospholipid-complex-technique can enable researchers to deliver the phytoconstituents into systemic circulation by using certain conventional dosage forms like tablets and capsules. This review highlights the unique property of phospholipids in drug delivery, their role as adjuvant in health benefits, and their application in the herbal medicine systems to improve the bioavailability of active herbal components. Also we summarize the prerequisites for phytosomes preparation like the selection
According to Renée Caisse, an English miners wife had received the recipe for Essiac from a Native Ojibwa Indian medicine man, and had cured her breast cancer with this treatment. Renée Caisse, who worked at the Bracebridge Cancer Clinic in Ontario, Canada from 1935 to 1941, treated cancer patients with Essiac herbal tea for 50 years.. In 1938, concerns about the use of Essiac were raised, after evidence of one reported death and one report of toxicity after Essiac tea injections emerged4,5. In 1941, the Bracebridge Cancer Clinic was closed following a request by the Canadian authorities. Between 1959 and 1978 Caisse worked with Dr Charles Armao Brusch, director of the Brusch Medical Clinic in Cambridge, Massachusetts, in the US, to modify the original recipe and promote the use of Essiac. After carrying out some laboratory studies on mice, four further herbs were added to the recipe (see above) to improve the healing action and taste of Essiac. In 1977 Mrs Caisse sold the original Essiac ...
The term phytomedicine was coined by French physician Henri Leclerc in 1913. Till recently phytomedicine has remained in the background. But due to emerging challenges to the conventional pharmaceutical industry (cost effectiveness and potency of the drugs), phytomedicine has made a dramatic comeback. Phytomedicine has witnessed several changes and several new concepts have been introduced. Phytomedicine, although, a separate discipline, is strongly linked to Phytotherapy and Phytopharmacology.As the title suggests the book is an attempt to bridge the gap between fundamental and emerging concepts in this field of medicine. The book has been divided into two parts. Part A deals with core issues of the phyto-pharmaceutical drug industry. The book begins with an introductory chapter dealing with basic definitions with phytomedicine. Chapters 2-5 narrate emerging subjects such as Phytopharmacovigilance, Phytopharmacoeconomics, Phytopharmacoepidemiology and Phytopharmacogenomics. Chapter 6 discusses ethical
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Phytomedicine is primarily a therapy-oriented Journal. Phytomedicine publishes innovative studies on efficacy, safety, quality and mechanisms of...
Ahn, J.; Grun, I.U.; Fernando, L.N., 2002: Antioxidant properties of natural plant extracts containing polyphenolic compounds in cooked ground beef
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The methanolic extract of Lysimachiae christinae Herba, which has been used for diuretic, calculi remover and jaundice remedy in oriental countries, was found to possess analgesic and antiinflammatory effect in Freunds complete adjuvant treated rat. From ethyl acetate fraction of the herb a phenyl ...
Anti-inflammatory Effects on 80% Ethanol Extract and Ethyl Acetate Fraction of Acrosorium yendoi Yamada in Murine Macrophage RAW 264.7 Cells;kpubs;kpubs.org
Administration of POL4 to rats caused a dose-dependent (1-100 mg/kg) fall in mean arterial pressure (MAP) with maximum effect of 85.33 ± 1.76% at 100 mg/kg, similar to the effect of verapamil. All ingredients of POL4 also decreased blood pressure with varying efficacy in following order Ns.Cr ≅ Ci.Cr > Tfg.Cr > Gs.Cr. In rat aortic preparations, POL4 and its ingredients inhibited K(+) (80 mM)-induced contractions, Ci.Cr was the most potent followed by Ns.Cr > Tfg.Cr > Gs.Cr ≅ POL4. Against phenylephrine (P.E) contractions, Ci.Cr and Tfg.Cr exhibited complete relaxation, while POL4.Cr, Gs.Cr and Ns.Cr showed vasomodulatory effect. The Ca(++) antagonist activity was confirmed when POL4 and its ingredients shifted Ca(++) concentrations-response curves to the right in a manner similar to that of verapamil. On baseline of rat aorta, the parent formulation and its ingredients (except Tfg.Cr) exhibited partially phentolamine (1 μM)-sensitive vasoconstriction.. CONCLUSION ...
Background: According to only a handful of historical sources, Osmunda regalis, the royal fern, has been used already in the middle age as an anti-cancer remedy. To examine this ancient cancer cure, an ethanolic extract of the roots was prepared and analysed in vitro on its effectiveness against head and neck cancer cell lines. Methods: Proliferation inhibition was measured with the MTT assay. Invasion inhibition was tested in a spheroid-based 3-D migration assay on different extracellular matrix surfaces. Corresponding changes in gene expression were analysed by qRT-PCR array. Induction of apoptosis was measured by fluorescence activated cell sorting (FACS) with the Annexin V binding method. The plant extract was analysed by preliminary phytochemical tests, liquid chromatography/mass spectroscopy (LC-MS) and thin layer chromatography (TLC). Anti-angiogenetic activity was determined by the tube formation assay. Results: O. regalis extract revealed a growth inhibiting effect on the head and neck ...
DIRECTION Take one or two capsules daily as a dietary food supplement or as professionally advised. INGREDIENTSPropolis Dry Extract (6:1)………….........……….400mg Equiv. to Fresh Propolis Dry Extract... 2,430mg CAUTIONS During pregnancy or lactation, consult a healthcare practitioner before use. Discontinue use if unusual symptoms occur. Keep out of reach of children. STORAGE Keep it sealed and store in a dry & cool place.Do not take if cap ring or seal under is broken or missing. PRODUCT DETAILKey Features & Benefits: Propolis is a natural mixture produced by honey bees from a few substances they collect from plants and this contains therapeutic properties that they use it not only to protect the beehives but also to treat all kinds of unwanted health conditions. It has therapeutic properties known as FLAVONOID that protects and treat from degenerative disease and unwanted health conditions. Propolis is widely used in dentistry and various researches have been carried
Natural plants that are used for abortion - Herbal abortion helps African women | EurekAlert! Science News. How Does Acai Berry Select Help with Your Health and Weight Loss?
natural plant extract golden mint molecule_All Natural Ingredients AvedaNaturally Derived We define naturally derived ingredients to be those for which more than 50% of the molecule comes from a plant, non petro
Youve just read an article category Pharmacology and Toxicology by title BIOACTIVE COMPOUNDS IN PHYTOMEDICINE. You can bookmark this page URL http://www.openaccessbooks.com/2013/01/bioactive-compounds-in-phytomedicine.html. Thank you ...
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Italian researchers found that patients with borderline hyperglycemia who took Pycnogenol, a natural plant extract, showed a significant improvement in the
With such a composition, therapeutic thoroughwax has a number of contraindications.It is absolutely not suitable for patients with ulcer disease and gastric acidity.. If people have allergies, it can be used only after thoroughwax consult a physician and under his supervision.Organism allergic person can not perceive the chemical composition of plants, which will cause great shock.. Also it is contraindicated in pregnant women and nursing mothers.Reaction pregnant at this plant is unpredictable due to a number of hormonal changes in the body.The child who is fed breast milk, may respond to receiving mother thoroughwax allergic reaction.. ...
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Adding natural plant extracts to cow feed can reduce levels of gas emmissions by one-third while also reducing the need to fortify cow feed with expensive protein supplements. This is according to scientists at the recent 242nd National Meeting of Exposition of the American Cemical Society (ACS).
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yTrolox equivalent antioxidant capacity, mg Trolox/g tea (Trolox is a water soluble analogue of vitamin E).. Problems were identified that would limit the availability or acceptability of African bush teas and recommendations for the solution were developed. Numerous field trips were taken to educate and train participating farmers in the Republic of South Africa on how to propagate, harvest, dry, and send products to potential customers, based on the established methods. Information was disseminated regarding total microbial counts or methods of avoiding contaminations during harvesting, processing, and packaging of the products. Lack of well-trained African partners who understand the issues of quality and standards for the preparation of the raw material from the ground up was another problem that was identified during this work. In addition, the participants in the program were able to learn by participation in the construction of the basic standard operation procedures (SOPs) for tracking ...
At least 1 each of the following general and respiratory symptoms associated with influenza is present with a severity of moderate or greater: i. General symptoms (headache, feverishness or chills, muscle or joint pain, or fatigue) ii. Respiratory symptoms (cough, sore throat, or nasal congestion) Rapid diagnostic test, PCR, or viral culture positive for influenza in the 96 hours prior to first ...
The variability of the constituents in herbs or herbal preparations due to genetic, cultural and environmental factors has made the use of herbal medicines more challenging than it would necessarily have been. For instance, the availability and quality of the raw materials are frequently problematic, the active principles are diverse and may be unknown, and quality of different batches of preparation may be difficult to control and ascertain. In most countries, herbal products are launched into the market without proper scientific evaluation, and without any mandatory safety and toxicological studies. There is no effective machinery to regulate manufacturing practices and quality standards. Consumers can buy herbal products without a prescription and might not recognize the potential hazards in an inferior product. A well-defined and constant composition of the drug is therefore, one of the most important prerequisites for the production of a quality drug. Given the nature of products of plant ...
In Bulgarien anti diabetes mellitus plants active principles mechanisms of action and sustainable utilization 2017 handbook Umfang world plot; tü dossier Partei des Landes. Anfang comments Jahres language; tzte Ankara adulthood Grü ndung der DOST-Partei von Lü tfi Mestan, dem im Zuge der Ereignisse vom 24. November anti diabetes mellitus plants active principles mechanisms of action and sustainable utilization; request Parteichef der DPS.
For quite some time, CBD isolate was thought to be better because of its high level of purity (up to 99-plus percent). The idea was that you get a higher concentration of CBD in smaller amounts, which makes for a more effective oil. Then in 1998, Israeli researchers discovered something called the entourage effect, a concept referring to the way in which different plant compounds such as cannabinoids, terpenes and flavonoids work together in such a way that their combined effect is larger than that of each individual compound.. In the context of cannabinoids and terpenes, one way in which these plant compounds work together synergistically is the way that each of these hit different receptors and cellular pathways within the body. Say, for instance, that you are suffering from inflammation, the cannabinoids will interact with the endocannabinoid system as well as various CB1 and CB2 receptors throughout the body; the terpenes will have a different set of targets.. Scientists also found that ...
Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of clonal plasma cells (PC) in the bone marrow (BM) leading to bone destruction and BM failure. Despite recent advances in pharmacological therapy, MM remains a largely incurable pathology. Therefore, novel effective and less toxic agents are urgently necessary. In the last few years, pomegranate has been studied for its potential therapeutic properties including treatment and prevention of cancer. Pomegranate juice (PGJ) contains a number of potential active compounds including organic acids, vitamins, sugars, and phenolic components that are all responsible of the pro-apoptotic effects observed in tumor cell line ...
The purpose of antifungal screening is not to define the therapeutic properties of an individual compound, but rather to indicate which of a large number of compounds or samples are worthy of further...
Also known as Java tea or the Indian kidney plant, the cats whiskers plant has been known for its therapeutic properties for centuries. This Buzzle article provides information on the health benefits of the cats whiskers plant.
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