Placental lactogen, also called chorionic somatomammotropin, is a polypeptide placental hormone, part of the somatotropin family. Its structure and function is similar to that of growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. For information on the human form, see human placental lactogen. Placental lactogen I and II were identified as prolactin-like molecules that can bind to prolactin receptor with high affinity and mimic the actions of prolactin. These hormones can contribute to lactogenesis, luteal maintenance and progesterone production (in rats) during the later stages of gestation. Placental lactogen I may be important in stimulating mammary cell proliferation and in stimulating some of the adaptations of the maternal lipid and carbohydrate metabolism. ...
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Single assays of Schwangerschaftsprotein 1 (SP1) and serum human placental lactogen (HPL) were performed in 500 consecutive patients attending a routine ante-natal clinic for their first visit. All samples were taken before 112 days gestation. Of the
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Lekva, Tove; Berg, Jens Petter; Lyle, Robert; Heck, Ansgar; Bollerslev, Jens & Ueland, Thor (2015). Alternative splicing of placental lactogen (CSH2) in somatotroph pituitary adenomas. Neuro - endocrinology letters. ISSN 0172-780X. 36(2), s 136- 142 Vis sammendrag OBJECTIVES: Somatotroph adenomas secrete supraphysiological amounts of GH, causing acromegaly. We have previously shown epithelial splicing regulator 1 (ESRP1) to play a role in epithelial mesenchymal transition (EMT) progression in these adenomas and account for poor treatment response. We evaluated if the mRNA levels of the GH/CSH gene cluster in somatotroph adenomas are associated with an epithelial phenotype and response to SA treatment. METHODS: We investigated the associations between ESRP1 and the growth hormone/chorionic somatomammotropin (GH/CSH) gene cluster by RNA sequencing (RNAseq). CSH2 isoform 3 mRNA was further evaluated in 65 somatotroph adenomas and associations with disease severity and treatment response. RESULTS: ...
In the serum of 145 women between the 34th and 42nd weeks of pregnancy, 209 radioimmunological determinations of human placental lactogen were made, using the Pharmacia, Uppsala, Sweden, HCS Phadebas Test. Following the determination of normal HPL levels in late pregnancy, the HPL values of high-risk pregnancies were investigated in relation to normal values and compared with the clinical pattern. A satisfactory relation was found between low HPL levels and fetal growth retardation. To some extent the HPL data can also be used in monitoring severe EPH-gestosis and postmaturity. Light cases of gestosis and pregnancies involving Rh-incompatibility do not affect HPL production. The clinical findings regarding HPL levels should not be overestimated in attempting to diagnose placental insufficiency ...
During pregnancy, the placenta supplies a growing fetus with nutrients and water, as well as produces a variety of hormones to maintain the pregnancy. In early pregnancy, hormones can cause increased insulin secretion and decreased glucose produced by the liver, which can lead to hypoglycemia (low blood glucose levels). In later pregnancy, some of these hormones (estrogen, cortisol, and human placental lactogen) can have a blocking effect on insulin, a condition called insulin resistance.. As the placenta grows, more of these hormones are produced, and insulin resistance becomes greater. Normally, the pancreas is able to make additional insulin to overcome insulin resistance, but when the production of insulin is not enough to overcome the effect of the placental hormones, gestational diabetes results or there may be worsening of pregestational diabetes.. ...
During pregnancy, the placenta supplies a growing fetus with nutrients and water, as well as produces a variety of hormones to maintain the pregnancy. In early pregnancy, hormones can cause increased insulin secretion and decreased glucose produced by the liver, which can lead to hypoglycemia (low blood glucose levels). In later pregnancy, some of these hormones (estrogen, cortisol, and human placental lactogen) can have a blocking effect on insulin, a condition called insulin resistance.. As the placenta grows, more of these hormones are produced, and insulin resistance becomes greater. Normally, the pancreas is able to make additional insulin to overcome insulin resistance, but when the production of insulin is not enough to overcome the effect of the placental hormones, gestational diabetes results or there may be worsening of pregestational diabetes.. ...
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul ...
The great changes in methods of assaying hormones that have occurred over the past decade and the large volume of important clinical data obtained with these assays are the main reasons given by the authors for this new edition of their book.. The book deals with selected areas of hormone assays, but, reflecting the authors own interest and expertise, the greatest emphasis is on reproductive endocrinology. Much of the clinical information in this area is based on the experience of the Endocrinology Unit at Edinburgh. The chapters on gonadotrophins, human placental lactogen, prolactin, estrogens, progesterone, testosterone, and reproductive hormone interrelationships ...
When to get a pregnancy test from the doctor a result of toxoplasma gondii parasite present in uncooked meat poultry expecting planned parenthood providence reviews can expertise how does oestrogen and progesterone prevent pregnancy poisoning. Hire particulars are offered under or your native NCT branch might be able to put you in contact with somebody local to you. A beginning doula presents physical and emotional help to you (and your associate) throughout labour and supply. 2008;(2):CD002807. Now, everyone knows about cravings. Cervical polyps. After investigation, docs estimated that she was about 12,5 months pregnant before she gave beginning to a daughter. And when you have your actual period, the flow is noticeably heavier and lasts up to per week. The hormones oestrogen, progesterone, human placental lactogen, oxytocin and prolactin prepare your physique for feeding your child and cause your breasts to enlarge. 5 to 24. Because the egg will reside for less than 24 hours, you might assume ...
Maternal pregnancy is divided into three stages of growth and development - the first trimester which involves organogenesis via cellular proliferation, differentiation, and morphogenesis; the second trimester which is centred around organ development and functioning as well as foetal expansion and recognisable movement (quickening); and the third trimester during which the foetus undergoes rapid weight gain. ==Second Trimester Foetal Development== The second trimester encompasses the foetal weeks 12-24, or clinical gestational weeks 14-26, according to the UCSF Medical Centre and is referred to as the "golden period of pregnancy" since many first trimester discomforts such as nausea, fatigue, breast tenderness, and frequent urination are alleviated as the maternal body adapts to the changing gestational physiology - nevertheless increased placental secretions of progesterone, estrogen, and human placental lactogen, as well as increased abdominal pressure can elicit heartburn, ...
The second trimester encompasses the foetal weeks 12-24, or clinical gestational weeks 14-26, according to the UCSF Medical Centre and is referred to as the "golden period of pregnancy" since many first trimester discomforts such as nausea, fatigue, breast tenderness, and frequent urination are alleviated as the maternal body adapts to the changing gestational physiology - nevertheless increased placental secretions of progesterone, estrogen, and human placental lactogen, as well as increased abdominal pressure can elicit heartburn, constipation, abdominal pain, and leg cramps. During the second trimester of pregnancy, the organ rudiments formed in the embryo stage expand in size and further differentiate in response to cellular signalling and gene cascades to coordinate specialised physiological functions needed to support the growing foetus. The foetus begins to exert pressure on the mothers stomach and bladder, and by month 5 limb movements can be felt. In addition to foetal growth and ...
RefSeq Summary (NM_002059): The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008 ...
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Somatotropic axis. Growth hormone. Pituitary protein hormone 191 amino acids 22 kDa Non-glycosylated Two disulfide bridges Shares homology with prolactin, placental lactogen, and GH-variant Gene duplication. Human GH gene Located in chromosome 17 66 kb in length Slideshow 6712355 by orestes-kristopher
No shortage of mothers, and no shortage of sad tales. Because bottlefeeding is more than a health tragedy in this country: it is an economic tragedy, too. Happi Akther, 35, talks to me as she waits to see a doctor about her nine-month-old sons flaky-skin problem: Nur has been bottlefed, she says, since he was about a month old. "I felt I didnt have enough milk," says Happi, whose two previous babies both died soon after birth. "What else could I do? No one had any other ideas." (In fact, breastfeeding experts believe at least 98% of women - even those on nutritionally deficient diets in developing countries such as Bangladesh - can make sufficient milk to feed their babies, given proper advice and support.) Nur has been fed on Lactogen from the outset, but his formula, she says, costs her and her husband Gias, who works in a mustard-dyeing factory, around 800 taka (£2) a week. And if that doesnt sound much, set it against the fact that Gias earns only £6 a week. "We cant afford it at all," ...
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To conduct an pregnancy after essure novasure essuree, your physician or a lab technician will take a sample of blood. she could be very anxious she is pregnant as neither of us are prepared for a kid and she has never experienced this earlier than. While among the following signs may not necessarily mean pregnancy, these are essentially the most generally reported what does aetna cover for pregnancy clues. Galactorrhea (milk secretion from the nipple) is the product of the combined results of prolactin, glucocorticoids, progesterone, and human placental lactogen. Residence pregnancy exams range in sensitivity so depending on the pregnancy after essure novasure you have got purchased, some might pregnancy after essure novasure pregnancy earlier on than others. Illness also explains the cramping you reported. The test equipment is used too early in the pregnancy and hCG ranges are too low to be detected. Even with dependable relationship, some women have prolonged pregnancies for no apparent ...
Diabetes could generally be chalked up to either a deficiency in insulin secretion from pancreatic ß cells, or a decrease in insulin sensitivity in glucose requiring cells (or both). Under normal conditions, ß cells increase insulin secretion when blood glucose levels rise in order to maintain normoglycemia. As pregnancy progresses, insulin sensitivity decreases (around 50%+ by the end) while hepatic glucose production increases. These changes are likely mediated, at least in part, by placental factors and hormones (human placental lactogen, prolactin, estrogen and progesterone) given that these changes mostly revert once delivery occurs. GDM results from the inability of pancreatic ß cells to increase insulin production enough to deal with the decreased maternal insulin sensitivity and the increased maternal blood glucose. Data suggest that this inability is not caused by pregnancy, but is rather unmasked by pregnancy. GDM indicates an increased risk of developing type 2 diabetes mellitus ...
Growth Hormone. Growth hormone (GH) is a peptide hormone that is synthesized and released by somatotroph cells in the pars distalis of the pituitary gland. It belongs to a family of hormones known as the growth hormone family. This also includes prolactin (PRL) and placental lactogen. Despite the obvious differences in function, these hormones share a very similar structure. Likewise, GH and PRL are the only two non-tropic hormones synthesized and released from the anterior pituitary gland.. The synthesis and release of GH is directly regulated through its two hypophysiotropic hormones, growth hormone releasing hormone (GHRH) and growth hormone inhibiting hormone (GHIH, or somatostatin). Despite the direct regulation by these hormones, other hormones can affect the secretion of GH. Thyroid hormones are shown to have a direct effect on GH synthesis, ghrelin through the activation of the growth hormone secretatgoguge receptor (GHSR), and much like PRL, GH synthesis is directly downregulated by ...
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Placental mRNA expression levels of PlGF in normotensive (N) (n = 30), chronic hypertensive (CH) (n = 9), early-onset (EO) (n = 8) and late-onset (LO) (n = 9) p
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We assessed the factors influencing the birth weight of infants born to 83 women with insulin-dependent diabetes mellitus (IDDM) over a 5-yr period. Maternal glycosylated hemoglobin (HbA1) concentrations at delivery correlated with the percentile birth-weight ratios (r = .43, P , .001) and indicated that ∼18% of variance in the birth weight could be ascribed to glycemic control in the third trimester. Fetal macrosomia occurred in 22 (27%) pregnancies. When 20 of these pregnancies were compared closely with 20 nonmacrosomic pregnancies in diabetic women, the mothers of macrosomic infants were found to be more obese, have a history of previous macrosomic birth, and have higher concentrations of serum human placental lactogen and urinary estriols in the third trimester. Macrosomic pregnancy was further distinguished by accelerated fetal growth (judged by serial ultrasonography) from the 32nd wk of gestation and by biochemical (but asymptomatic) hypoglycemia in the neonate. In our study, no ...
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Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum) to determine prolactin (PRL), a hormone secreted by the anterior lobe of the pituitary gland that stimulates and sustains lactation. High levels of prolactin (also known as lactogen) are found in pregnant women and also in women with minor alterations of fertility, such as absence of ovulation with or without menstrual irregularity or abnormal secretion of milk (galactorrhea). The level of prolactin also increases in some diseases, including pituitary adenoma, and after the administration of some drugs (e.g., tricyclic antidepressants).. Entry Terms : "Prolactin (PRL) Determination Reagents" , "PRL (Prolactin) Determination Reagents" , "Lactogen Determination Reagents" , "Reagents, Immunoassay, Fertility Hormone, Prolactin". UMDC code : 19119 ...
Radioimmunoassay for ovine, caprine and bovine prolactin in plasma and tissue extracts: 1. A radioimmunoassay for ovine prolactin is described based on the inhi
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Phosphorylated prolactins and growth hormones have been found in several species and the phosphorylation sites of prolactin have been identified in bovine and rat. We have isolated phosphorylated bovine prolactin (Mol. Cell. Endo. 99: 301, 1994) and have evidence that phosphorylated prolactin is the major form in the bovine pituitary. We have shown bovine prolactin is phosphorylated in vivo at serine 90 and to a lesser extent at serines 26 and 34 (Biochem. J. 296: 41, 1993). Isolated phosphorylated bovine prolactin has reduced biological activities both in vitro (Mol. Cell. Endo. 112: 223, 1995) and in vivo (Life Sciences 63:1281-1287, 1998). We have used site-directed mutagenesis to produce glutamic acid mimics of the individual phosphorylation sites and have identified serine 90 as a site where phosphorylation reduces biological activity (J. Biol. Chem. 270: 27661, 1995). We have shown that prolactin is phosphorylated in secretory vesicles and that this process is zinc-dependant (Molec. Cell. ...
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The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver.
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