Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids. Cytauxzoon felis induces severe and often fatal disease in domestic cats. In Europe, clinical and subclinical infections caused by Cytauxzoon sp. are described. We report the first cases of Cytauxzoon sp. infection in domestic cats in Switzerland. Clinical and laboratory data and results of PCR analyses were collected from Cytauxzoon sp. PCR-positive cats and the cats followed for up to 851 days. The cases were three two-month old kittens from the same litter (Cases 1-3) and two adult domestic shorthair cats (Cases 4 and 5). The cats originated from the north-west and west of Switzerland. Cases 1-3 presented with moderate to severe regenerative anaemia and intraerythrocytic inclusions. Cytauxzoon sp. was confirmed by PCR and sequencing. The kittens made a clinical and haematological recovery after blood transfusion and/or treatment with azithromycin and atovaquone, but erythroparasitaemia persisted. Case 4 presented with
By Jennifer Copley (Last Updated 6 December 2011). Bobcats, which live throughout lower Canada, the U.S. and Mexico, act as hosts to the Cytauxzoonosis parasite. Bobcats dont die from the parasite, but they can transmit it to domestic cats via ticks. Bobcat Fever is usually fatal to domestic cats.. Risk Factors. Ticks present the greatest danger in spring, summer and early fall, particularly for cats that live in or near wooded areas. Outdoor cats are at greater risk because they are more likely to pick up ticks.. Symptoms. Bobcat Fever attacks a cats white blood cells, causing them to become distended with the developing parasites. This blocks the flow of blood through small vessels, having an adverse effect on the majority of body organs. The parasite causes blood clotting abnormalities, fluid in the lungs and anemia when the organisms rupture out of the white blood cells where they have been incubating to invade the red blood cells. Cytauxzoonosis symptoms include:. ...
Cytauxzoon felis is a tick-borne protozoal disease of domestic and wild cats. In domestic cats the disease is usually fatal. The disease was first described in 1973 and since then has predominantly been reported in the south central and southeastern areas of North America. EPIDEMIOLOGY. Cytauxzoon has both an erythrocytic and tissue phase, whereas the babesias only have an erythrocytic phase, which is morphologically indistinguishable from the erythrocytic phase of Cytauxzoon. There is no serological cross-reactivity between the small babesias (B. felis, B. equi, and B. rodhaini) and Cytauxzoon, however on PCR there is enough similarity between these organisms to re-classify them as a separate family.. Cats acquire the infection in rural and wooded areas as probably accidental and dead-end hosts. The bobcat appears to be the reservoir host for the disease. The highest incidence of the disease is in the summer months and in cats that roam and thus have exposure to ticks.. The disease is thought ...
Cytauxzoon is a protozoal organism that is transmitted by ticks and causes big, big problems for cats. It is most commonly seen in cats who live in the south central and
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Ticks can transmit dangerous diseases, like cytauxzoonosis, when they attach to a cat and feed. Your veterinarian can recommend safe and effective prod...
Images of histological specimens from the lungs of animals under transmission electron microscope (×30,000). (A) control group; (B) KGF-2 group; (C) HVZP group
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I am trying to generate a summary of parasites in human metagenomic samples. I have been looking into Kraken2 and its databases built from Refseq (which should contain all parasite sequences annotated). Have also noticed this DB available from EuPathDB:. https://ccb.jhu.edu/data/eupathDB/. Is it a good approach to solely use EupathDB or should I be looking into other DBs for any missing parasites that might not be included there?. ...
Comment and Authors Response In principle, this case looks like a good way to talk about cell structure in an introductory course. However, I was VERY disappointed by this case, for several reasons: (1) In this case, the researchers examine a blood sample microscopically and identify Gram-negative bacteria by their size, presence of DNA and outer membranes! Its not made clear until later that they used an electron microscope, which is likely to lead to the misconception that a light microscope could be used to perform this analysis. More importantly, it leads to the misconception that electron microscopy would be used to identify an infectious agent. Instead, why not teach methods of identifying prokaryotic and eukaryotic pathogens that might actually be used, such as Gram staining to identify a Gram-negative pathogen? Authors Reply: The gram staining method is briefly mentioned in the case as well as in the case teaching notes. In the interest of keeping the slides to a minimum of text and ...
Comment pages provide a way to add additional information from the community to a page. This can be as simple as the gene name assigned, a link to a publication, GenBank Accession of the sequence, or descriptive text about a mutant phenotype. The comments can also describe corrections or additions to the gene model which can be noted. Currently the EuPathDB system does not allow direct manipulation of the gene model from the page as these types of updates need vetting and technical work to re-analyze the updated protein sequence in the downstream analyses (e.g. Pfam, InterPro, homology assignments, etc). For SXI1 there is a comment which links the gene to several publications and submitted accession numbers. Since multiple strains have been studied for this gene, but not all are part of FungiDB, it may be useful to have direct links to the sequence variants for someone wanting to do followup work on the gene and the key residues.. ...
Small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), are important regulators of eukaryotic gene expression by guiding mRNA cleavage, translational inhibition or chromatin modification. We utilize genomics, genetics, molecular and biochemical approaches to identify and functionally characterize infection-regulated small RNAs, including those from plant hosts and from eukaryotic pathogens. My lab provided the first example of a plant endogenous siRNA that regulates plant immune responses. We further discovered that some small RNAs from aggressive fungal pathogens are delivered into host cells to hijack host RNAi machinery to suppress host immunity genes. These studies have added small RNAs to the list of pathogen effectors, which unveiled a novel virulence mechanism in aggressive eukaryotic pathogens. The transport of small RNAs from fungal pathogens to plant hosts also represents a naturally occurring cross-kingdom RNAi event. We recently show that such cross-kingdom ...
International Medical and medicine Journal (ISSN:13412051) is a monthly peer reviewed fast publishing international medical and medicine journal that aims to publish good quality of Medical and pharmaceutical, medicine and health science Journal.
Singer Justin Timberlake was targeted by serial prankster Vitalii Sediuk as he arrived at the Louis Vuitton Paris Fashion Week show on Tuesday afternoon with wife Jessica Biel.
Helminth parasites are complex eukaryotic pathogens, which can affect a variety of different human tissues. The immune response is characterised by a Type 2
MicrobiomeDB (http://microbiomeDB.org) is a data discovery and analysis platform that empowers researchers to fully leverage experimental variables to interrogate microbiome datasets. MicrobiomeDB was developed in collaboration with the Eukaryotic Pathogens Bioinformatics Resource Center (http://EuPathDB.org) and leverages the infrastructure and user interface of EuPathDB, which allows users to construct in silico experiments using an intuitive graphical strategy approach. The current release of the database integrates microbial census data with sample details for nearly 14 000 samples originating from human, animal and environmental sources, including over 9000 samples from healthy human subjects in the Human Microbiome Project (http://portal ...
Bostjan Batagelj, Vesna Erzen, Jurij Tratnik, Luka Naglic, Vitalii Bagan, Yury Ignatov, Maxim Antonenko. COLLA 2012, The Second International Conference on Advanced Collaborative Networks, Systems and Applications. COLLA 1: Collaborative applications I ...
Buy or license direct from the photographer this stunning image of : Olive Baboon , Papio Cynocephalus Anubis , Lake Manyara National Park , Tanzania
Buy or license direct from the photographer this stunning image of : Yellow Baboon , Papio Cynocephalus , Selous Game Reserve , Tanzania
Nucleic Acids Res. 2013 Jan;41(Database issue):D684-91. doi: 10.1093/nar/gks1113. Epub 2012 Nov 21. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P.H.S.
BACKGROUND Molecular testing of lung adenocarcinomas (ADCs) is crucial for therapy stratification of patients. Because of the often limited diagnostic material, the authors aimed to explore the suitability of cytology smears for next-generation sequencing (NGS) and compared the results with concurrent histological specimens or cell blocks. METHODS A total of 16 formalin-fixed paraffin-embedded (FFPE) ADCs with known genetic alterations were used as the first cohort for targeted DNA and RNA sequencing. In the second cohort of 8 cases, 8 cytological smears were compared with matching histological specimens or cell blocks for the study. For NGS library amplification, commercially available panels for DNA and RNA sequencing were applied. The Ion Torrent Personal Genome Machine and the Ion Reporter workflow (version 5.0) were used for sequencing. RESULTS All DNA libraries derived from FFPE and non-formalin-fixed cytological smear samples produced acceptable quality metrics, thereby enabling ...
Anemia is mostly a manifestation of an underlying disease process rather than being a primary disease and it is one of the most frequent and difficult to be solved nosological problems in every day veterinary clinical practice. It is characterized by decreased packed cell volume (hematocrit) and/or decreased hemoglobin concentration. Clinical picture of anemia results from reduced oxygen delivery to tissues, which is insufficient to cover metabolic requirements.. Infectious agents are among the most frequent causes of anemia in cats including: 1. Hemoparasites, Haemobartonella, Cytauxzoon and Babesia spp and less often Ehrlichia and Leishmania species.. 2. Viruses and mainly FeLV and FIV and 3. A variety of inflammatory diseases. Hemoparasites cause regenerative anemia and consequently reversible, either of acute or chronic type. To the contrary both anemia due to viruses and to inflammatory state (Anemia of Inflammatory Disease-AID) are chronic and of the hypoplastic or aplastic form.. ANEMIA ...
This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201400029C.. Bioinformatics Resource Centers for Infectious Disease: VectorBase , EuPathDB , IRD , PATRIC , ViPR ...
This project has been funded in whole or in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201400029C.. Bioinformatics Resource Centers for Infectious Disease: VectorBase , EuPathDB , IRD , PATRIC , ViPR ...
Oklahoma Animal Disease Diagnostic Laboratory (405) 744-6623 FAX (405) 744-8612 Teaching Hospital Small Animal (405) 744-7000 Large Animal (405) 744-7000 Administration (405) 744-7000 Outreach (405) 744-7672 FAX (405) 744-6265 In this Issue: Veterinary Clinical Sciences Welcome to Dean Jean Sander Scrapie: A regulatory perspective Equine Herpes Virus Type I Alternative therapeutic options for management of chronic or recurring urinary tract disease Anthelmiatics use in goats Service dogs and veterinary medicine OADDL Cytauxzoonosis Common herbicide/pesticide questions Equine piroplasmosis Trichomoniasis in Oklahoma Fall Conference 2011 Animal Health Update SUMMER 2011 The Newsletter of the Center for Veterinary Health Sciences Oklahoma State University Consultations and referrals can be made by contacting the Oklahoma State University Veterinary Medical Teaching Hospital at (405) 744-7000 or The referring veterinarian toll free line at 1-866-654-7007. Veterinary Clinical Sciences Center for ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Contingency genes are common in pathogenic microbes and enable, through pre-emptive mutational events, rapid, clonal switches in phenotype that are conducive to survival and proliferation in hosts. Antigenic variation, which is a highly successful survival strategy employed by eubacterial and eukaryotic pathogens, involves large repertoires of distinct contingency genes that are expressed differentially, enabling evasion of host acquired immunity. Most, but not all, antigenic variation systems make extensive use of subtelomeres. Study of model systems has shown that subtelomeres have unusual properties, including reversible silencing of genes mediated by proteins binding to the telomere, and engagement in ectopic recombination with other subtelomeres. There is a general theory that subtelomeric location confers a capacity for gene diversification through such recombination, although experimental evidence is that there is no increased mitotic recombination at such loci and that sequence ...
Authors: Lewandrowski, Kai‐Uwe , Bondre, Shrikar P. , Wise, Donald L. , Trantolo, Debra J. Article Type: Research Article Abstract: The tissue response of subchondral bone to a biodegradable fixation device manufactured in the shape of a screw and made of polylactide with a hydroxyapatite buffer were implanted through the articular surface of the intercondylar portion of the distal rabbit femur. One screw was implanted per animal. The screws had a core diameter of 3.2 mm and an outer diameter of 4.5 mm. At insertion, the implants were cut flush with the articular surface. After follow‐up times of 8 and 16 weeks, the specimens were examined radiographically and histomorphometrically. The intact contralateral femur served as a control for comparison. Only …minimal signs of degradation of the polymer could be seen in the histologic specimens. These implant degradation sites were commonly areas of new bone formation adjacent to the screw implant. A brim of repair tissue was formed at the ...
kenya75 - Kenya - Lake Nakuru National Park - Rift Valley province: olive baboon female with baby - papio cynocephalus (photo by F.Rigaud) - Travel-Images.com - the global image bank - Stock photography agency - view and buy image rights
to i) help identify the most significant human eukaryotic pathogens and invertebrate vectors of infectious diseases for potential sequencing; ii) evaluate the usefulness and limitations of pathogen and vector genomic data for studying infectious diseases; and iii) discover potential targets for vaccines, therapeutics, diagnostics, and vector control. In response to recommendations developed at the workshop, the two institutes established a Human Pathogens and Disease Vectors Sequencing Target Selection Working Group (See Group Rosters). The group was charged to work in consultation with the scientific community to generate community-based sequencing projects and to recommend high priority human eukaryotic pathogens and invertebrate vectors as potential sequencing targets. All sequencing targets and rationales proposed by the Working Group will be assessed by the Coordinating Committee for Sequencing Target Selection (See Group Rosters), the National Advisory Council on Human Genome Research, and ...
Postmortem computed tomography (pmCT) and pmCT angiography (pmCTA) provide a minimally invasive method to determine the cause of death. Postmortem image-guided biopsy allows for precise sampling of histological specimens. This case study describes the findings of lethal systemic fat embolism (FE) on whole-body unenhanced pmCT, pmCTA, and image-guided biopsy, with autopsy and histopathologic correlation. Unenhanced pmCT revealed a distinct fat level on top of sedimented layers of corpuscular blood particles and serum in the arterial system and pulmonary trunk. Subsequent pmCTA showed reproducible results, and image-guided biopsy confirmed fatal FE. pm CT/pmCTA combined with image-guided biopsy established the cause of death as right heart failure as a result of systemic fatal FE prior to autopsy. All imaging findings were consistent with traditional autopsy and histological specimens. This unique case demonstrates new imaging findings in massive, fatal FE and highlights that postmortem imaging, ...
How an animal moves through its environment directly impacts its survival, reproduction, and thus biological fitness. A basic measure of describing how an individual (or group) travels through its environment is Day Path Length (DPL), i.e., the distance travelled in a 24-hour period. Updating a classic study by Dunbar (1992), we investigate the ecological determinants of mean DPL for 39 baboon (Papio spp.) troops across 20 different populations. We find that a measure of plant productivity, anthropogenic influence and local primate richness all have a significant and negative effect on DPL, whilst group size has a significant positive effect. These results are in accordance with previous work indicating baboons show variation in DPLs as a consequence of ecological dissimilarity across their range. We then explore DPLs and Movement Trajectories (MTs: the speed and tortuosity of travel) for yellow baboons (Papio cynocephalus) in the Issa Valley of western Tanzania. We find that Issa baboons travel ...
Gesquiere, LR; Khan, M; Shek, L; Wango, TL; Wango, EO; Alberts, SC; Altmann, J (2008). Coping with a challenging environment: Effects of seasonal variability and reproductive status on glucocorticoid concentrations of female baboons (Papio cynocephalus). Hormones and Behavior, 54 (3), 410-416. ...
The entomological inoculation rate (EIR) is an important indicator in estimating malaria transmission and the impact of vector control. To assess the EIR, the enzyme-linked immunosorbent assay (ELISA) to detect the circumsporozoite protein (CSP) is increasingly used. However, several studies have reported false positive results in this ELISA. The false positive results could lead to an overestimation of the EIR. The aim of present study was to estimate the level of false positivity among different anopheline species in Cambodia and Vietnam and to check for the presence of other parasites that might interact with the anti-CSP monoclonal antibodies. Mosquitoes collected in Cambodia and Vietnam were identified and tested for the presence of sporozoites in head and thorax by using CSP-ELISA. ELISA positive samples were confirmed by a Plasmodium specific PCR. False positive mosquitoes were checked by PCR for the presence of parasites belonging to the Haemosporidia, Trypanosomatidae, Piroplasmida, and
Vitalii V. Klochko,* Liubov B. Zelena, Sergei I. Voychuk, and Andriy N. Ostapchuk. The phenotypic, chemotaxonomic and genetic peculiarities of 5 deep strains of Alteromonas macleodii (isolated from Adriatic and Ionian Sea water from a depth of 1,000‒3500 m) and 5 strains of the same species isolated from the surface layer of Aegean, Andaman, Black Sea and Atlantic Ocean water near the British shore have been studied. Electron microscopy has shown that the deep strains cells were, on average, two times longer (2.1 ±0.2× 0.7±0.1 μm) than the surface strains (1.1 ±0.1×0.6±0.1 μm). Using fatty acid analysis (particularly the mono-unsaturated C16:1 and C18:1 fatty acids contents) the deep and surface isolates were clearly separated into two clusters. Distinctions between them were also found in different lectin binding capacity, which is probably determined by the structure of their extracellular polysaccharide matrix. Analysis of the results of PCR with primers to repeated nucleotide ...
Background and Aim: A recently carried out randomized controlled trial showed the benefit of a novel 20-G fine-needle biopsy (FNB) over a 25-G fine-needle aspiration (FNA) needle. The current study evaluated the reproducibility of these findings among expert academic and non-academic pathologists. Methods: This study was a side-study of the ASPRO (ASpiration versus PROcore) study. Five centers retrieved 74 (59%) consecutive FNB and 51 (41%) FNA samples from the ASPRO study according to randomization; 64 (51%) pancreatic and 61 (49%) lymph node specimens. Samples were re-reviewed by five expert academic and five non-academic pathologists and rated in terms of sample quality and diagnosis. Ratings were compared between needles, expert academic and non-academic pathologists, target lesions, and cytology versus histological specimens. Results: Besides a higher diagnostic accuracy, FNB also provided for a better agreement on diagnosing malignancy (ĸ = 0.59 vs ĸ = 0.76, P , 0.001) and classification ...
Plasmodium falciparum causes the most severe form of malaria still killing about half a million children every year. Pathogenesis is linked to asexual proliferation in red blood cells and severity of malaria infection is predicted by parasite load. Even though mitosis is fundamental to the rapid proliferation of this eukaryotic pathogen it is poorly studied and thus presents an exciting new avenue for research. P. falciparum displays significant morphological differences when compared to any model organism suggesting that atypical cell division mechanisms are in place. By combining recent advances in live cell imaging, super-resolution microscopy, and genome-editing technologies we will aim to uncover those mechanisms ...
Background and Aims: The recent development of microforceps for EUS through-the-needle biopsy (TTNB) sampling of the wall of pancreatic cystic lesions (PCLs) allows the collection of histologic specimens never handled and evaluated before by pathologists. We aimed to estimate the interobserver agreement among pathologists in evaluating such samples. Methods: TTNB specimen slides from 40 PCLs with worrisome features were retrieved and independently evaluated for specimen adequacy, presence of lining epithelium, grade of epithelial dysplasia, presence of ovarian type stroma, and specific diagnosis by 6 expert pathologists from 6 different tertiary care centers. The Gwets AC1 was used to assess interobserver agreement. Results: An almost perfect agreement was observed for specimen adequacy (AC1, .82; 95% confidence interval [CI], .79-.98), presence of lesional epithelium (AC1, .90; 95% CI, .86-.92), epithelial dysplasia (AC1, .97; 95% CI, .95-.99), and ovarian-like stroma (AC1, .90; 95% CI, ...
Moving Out ofYour Parents House in GAthe legal age of majority in Georgia is eighteen (18). Georgia CodeTitle 39, Chapter 1, Article 1.
This is an irrefutable example of a domestic cat protecting a baby from a man (the father) who pretends that he is hurting his baby. It is a rather bizarre video really because I disagree with the behavior of the man. There is something distasteful about it. However, the behavior of the cat is first rate. I dont think the man gave any thought to how his actions might affect his relationship with his cat.. https://youtu.be/QVAvwykLkBc. We can see that the cat understands that the man (a person she knows) is hurting the baby who she also knows. How is this information processed by the cat? Does she begin to believe that the man is bad and dangerous? She might. If she does it might affect the relationship between cat and man.. You can tell that in the past the cat has defended the baby because the parents decided to make a video of it and to make the video they had to set it up and pretend that the baby was being hurt. But was the baby really hurt before? A wild question no doubt. ...
We are pleased to present below all posts archived in January 2011. If you still cant find what you are looking for, try using the search box.. ...
Kakha Bendukidze died in November 2014 at the age of 58. Bendukidze directed the whirlwind of economic reform that characterised Georgia from 2004 to 2008-9.
There are some challenges ahead as Ivanishvili and Saakashvili try to jointly govern this often fractious nation for the next year
This study aimed to compare the epidemiology of Rickettsia felis infection and malaria in France, North Africa, and sub-Saharan Africa and to identify a common vector. Blood specimens from 3,122 febrile patients and from 500 nonfebrile persons were analyzed for R. felis and Plasmodium spp. We observed a significant linear trend (p<0.0001) of increasing risk for R. felis infection. The risks were lowest in France, Tunisia, and Algeria (1%), and highest in rural Senegal (15%). Co-infections with R. felis and Plasmodium spp. and occurrences of R. felis relapses or reinfections were identified. This study demonstrates a correlation between malaria and R. felis infection regarding geographic distribution, seasonality, asymptomatic infections, and a potential vector. R. felis infection should be suspected in these geographical areas where malaria is endemic. Doxycycline chemoprophylaxis against malaria in travelers to sub-Saharan Africa also protects against rickettsioses; thus, empirical treatment
Current diagnosis of prostatic adenocarcinoma is done by manual analysis of biopsy tissue samples for tumor presence. However, the recent advent of whole slide digital scanners has made histopathological tissue specimens amenable to computer-aided diagnosis (CAD). In this paper, we present a CAD system to assist pathologists by automatically detecting prostate cancer from digitized images of prostate histological specimens. Automated diagnosis on very large high resolution images is done via a multi-resolution scheme similar to the manner in which a pathologist isolates regions of interest on a glass slide. Nearly 600 image texture features are extracted and used to perform pixel-wise Bayesian classification at each image scale to obtain corresponding likelihood scenes. Starting at the lowest scale, we apply the AdaBoost algorithm to combine the most discriminating features, and we analyze only pixels with a high combined probability of malignancy at subsequent higher scales. The system was ...
Looking for fashion events events in Valdosta? Whether youre a local, new in town, or just passing through, youll be sure to find something on Eventbrite that piques your interest.
Yesterday I was watching the internet critic Nostalgia Critic reviewing a god awful Don Bluth film. You know, that one that was really bad. I was thinking if only some ACTUAL cartoonist had a budget like that. Someone like you John, or Bob Camp, Jim Smith, Vincent Waller, or any of the old Spumco Alummni. You guys have talent within every fiber of your beings and all of you deserve a shot in features, hell, Id settle for just a short. ...