en] HIV-1 infection of the brain and PAF neurotoxicity are implicated in AIDS dementia complex. We previously reported that a trisubstituted piperazine derivative is able to diminish both HIV-1 replication in monocyte-derived macrophages and PAF-induced platelet aggregation. We report in this work new compounds obtained by modifying its piperazine substituents. The structure-activity relationship study shows that a better dual activity or even pure antiretroviral compounds can be obtained in this series. (c) 2006 Elsevier Ltd. All rights reserved ...
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TY - JOUR. T1 - Physical properties of aqueous blends of sodium glycinate (SG) and piperazine (PZ) as a solvent for CO2 capture. AU - Shaikh, M. S.. AU - Shariff, A. M.. AU - Bustam, M. A.. AU - Murshid, Ghulam. PY - 2013/3/14. Y1 - 2013/3/14. N2 - The physical properties including the density, viscosity, and refractive index of aqueous blends of sodium glycinate (SG) and piperazine (PZ) as a solvent for CO2 absorption were measured under the wide temperature range (298.15 to 343.15) K. Different concentrations (mole fraction) of sodium glycinate and piperazine (SG + PZ) blends were (0.0348/0.0089, 0.0263/0.0177, 0.0177/0.0263, and 0.0089/0.0348), respectively. From the observations, it was found that the densities of the aqueous blends decrease when the piperazine concentration in the blend increases. It was noticed that the viscosity of the blend decreases initially by increasing the concentration of piperazine from 0.0089 to 0.0177 mole fraction; however, on further increasing the piperazine ...
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In the scope of a research program aimed at developing new drugs for the treatment of central nervous system diseases, we describe herein the synthesis and pharmacological evaluation of 1-(4-(3,5-di-...
Looking for piperazine dihydrochloride? Find out information about piperazine dihydrochloride. C4H10N2·2HCl White, water-soluble needles; used for insecticides and pharmaceuticals Explanation of piperazine dihydrochloride
Application Notes: Piperazine is an organic hydrophilic basic compound containing two secondary amines. It is not retained on traditional reversed-phase columns without ion pairing reagent. Since piperazine is not UV active, alternative detection techniques like ELSD, CAD and LC/MS must be employed. Two fast methods of analysis on Primesep 100 and 200 columns were developed using reversed-phase cation-exchange approach. Primesep 200 column is more suitable for analysis since piperazine interacts strongly with stationary phase and since Primesep 200 columns are weaker columns. Methods can be used for analysis of piperazine and other basic hydrophilic compounds in reaction mixtures, formulations, biofluids, waste waters, etc. This Method is compatible with ELSD, CAD and LC/MS. ...
N-[4-(4-Methylpiperazin-1-yl)phenyl]-7-pyridin-3-ylpyrrolo[2,3-d]pyrimidin-2-amine | C22H23N7 | CID 23646631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
As a part of our ongoing research to develop novel and selective 5-HT6 receptor antagonists, a new series of 2-(4- methylpiperazin-1-yl methyl)-1-(ary..
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You are viewing an interactive 3D depiction of the molecule 1-(2-(bis(4-fluorophenyl)methoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine (C27H29F2IN5O) from the PQR.
Read about the chemical and physical properties of 1-(4-tert-butylphenylsulfonyl)-4-(4-fluorophenyl)piperazine. Get 1-(4-tert-butylphenylsulfonyl)-4-(4-fluorophenyl)piperazine molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
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Piperazine is an amine which is used both as an activator or promoter, but also as active component in CO2 capture solvents. High concentrations are being formulated to draw benefit of the PZ properties. This results in a risk of precipitation of PZ and other solid phases during capture. It could be a benefit to the capture process, but it could also result in unforeseen situations of potential hazardous operation, clogging, equipment failure etc.Security of the PZ process needs to be in focus. Flow assurance requires additional attention, especially due to the precipitation phenomenon. This entails all parts of the streams, but also during formulation and transport of the solvent.In this work the extended UNIQUAC thermodynamic model is presented with the addition of piperazine (PZ or PIPH2) in combination with the potassium ion of mixtures with CO2 in equilibration with KOH-KHCO3-K2CO3. Phase boundaries are laid out which shows the concentration regions of solid formation. A special focus will ...
1-(1-Methyl-4-piperidinyl)piperazine, 98%, ACROS Organics 1g; Glass bottle Chemicals:Organic Compounds:Organoheterocyclic compounds:Diazinanes:Piperazines:N-alkylpiperazines
Spectrophotometric method for determination of Cu(II) in the trace quantities was developed by using piperazine as ligand in ammonium acetate medium. The Procedure developed was applied for the estimation Cu(II) in microgram quantities in the samples of alloys and the method was found to be simple, rapid and comparable to routine analytical methods for trace level analysis of metal ions in environmental samples in any laboratory where sophisticated and expensive instruments are not available. UV visible spectrophotometer is cost effective and available in almost all laboratories. The complexes of piperazine in aqueous solutions are not reported so far and this is the first attempt in this area of spectrophotometric analysis.
(R)-CPP, CAS: 126453-07-4, is A piperazine derivative demonstrating highly potent NMDA receptor antagonism. Cited in 2 publications
2C-B-BZP produces stimulant effects that last 3-6 hours, depending on the dose. Despite its structural similarity to 2C-B it does not produce psychedelic effects as the binding groups are in the wrong position to activate the 5HT2A receptor. 2C-B-BZP is also said by several sources to increase the effects of other compounds when combined. Side effects include headaches and nausea, similar to other piperazine derivatives used recreationally. ...
1-(4-Methoxyphenyl)-4-[4-(5-propyl-1,2,4-triazol-1-yl)phenyl]piperazine | C22H27N5O | CID 12877036 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-[2-(Dimethylamino)ethyl]piperazine 97% | N,N-Dimethyl-2-(piperazin-1-yl)ethylamine, 1-(Dimethylamino)-2-(piperazin-1-yl)ethane | OR6907 | 3644-18-6 | Apollo Scientific Ltd
RZ-2;RS 94287;Ranolazine impurity G;Ranolazine Related CoMpound C;N-(2,6-Dimethylphenyl)-1-Piper;1-Piperazineaceto-2,6-xylidide;N-(2,6-DiphenylMethyl)-1-piperazine;N-(2,6-DIMETHYLPHENYL)-1-PIPERAZINEACETAMIDE;N-(2,6-DIMETHYLPHENYL)-1-PIPERAZIN-ACETAMIDE;1-(2,6-Dimethylphenyl)-1- ...
81816-68-4 - CCULRDJFKNULHF-UHFFFAOYSA-N - Piperazine, 1-(3,4-dihydro-2H-1-benzopyran-4-yl)-4-(2-methoxyphenyl)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
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You are viewing an interactive 3D depiction of the molecule 1,4-bis[3-(4-chlorophenyl)propyl]piperazine (C22H28Cl2N2) from the PQR.
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Guannan East Chemical Co., Ltd. (the original Yizheng East Chemical Co., Ltd.) is a comprehensive chemical enterprise engaged in researching, developing, manufacturing, and marketing pesticide, pharmaceutical and electronic intermediates.
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Kyron Laboratories (Pty) Ltd, a subsidiary of Ascendis Animal Health, was founded in 1990 in Johannesburg, South Africa. Kyron is a specialist animal health company which has built a reputation for quality products, innovation and professional integrity. The company manufactures and markets a wide range of products in the animal health field.
Piperazinyl derivatives of formula (I) and their use as a drug, particularly for the treatment of cancer, are disclosed. Also disclosed are pharmaceutical compositions comprising the piperazinyl deriv
Learn more about 2-piperazin-1-ylpyridin-4-yl-methylamine. We enable science by offering product choice, services, process excellence and our people make it happen.
TY - JOUR. T1 - Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl) piperazine derivatives as T-type calcium channel blockers. AU - Park, Jung Eun. AU - Ji, Wan Keun. AU - Jang, Jae Wan. AU - Pae, Ae Nim. AU - Choi, Keehyun. AU - Choi, Kihang. AU - Kang, Jahyo. AU - Roh, Eun Joo. PY - 2013/3/15. Y1 - 2013/3/15. N2 - To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and 6q showed high selectivity over hERG channel (IC50 ratio of hERG/α1G 6m = 8.5, 6q = 18.38) and they were subjected to measure pharmacokinetics profiles. Among them compound 6m showed an excellent pharmacokinetic profile in rats.. AB - To obtain selective and potent inhibitor for T-type calcium channel by ligand based drug design, 2-hydroxy-3-phenoxypropyl piperazine derivatives were synthesized and evaluated for in vitro activities. Compound 6m and ...
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