TY - JOUR. T1 - Transplantation of the mammalian pineal gland. T2 - Studies of survival, revascularization, reinnervation, and recovery of function. AU - Wu, Wutian. AU - Scott, David E.. AU - Reiter, R. J.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1993/7. Y1 - 1993/7. N2 - The survival, revascularization, reinnervation, and recovery of function of transplanted rat pineal glands were studied following grafting into four different locations in pinealectomized rats. Pineal grafts were well vascularized by fenestrated capillaries. Pinealocytes in the grafts maintained high-metabolic activity. More nerve fibers and terminals were observed in the grafts within the anterior chamber of the eye than in the third cerebral ventricle and the pineal region (in situ transplantation). No fibers or terminals were found in grafts placed beneath the renal capsule. Nighttime serum melatonin levels increased significantly in pinealectomized rats with transplants into either the ...
Retina and anterior neural fold homeobox (Rax) gene encodes a transcription factor essential for vertebrate eye development. Recent microarray studies indicate that Rax is expressed in the adult rat pineal gland and retina. The present study reveals that Rax expression levels in the rat change significantly during retinal development with a peak occurring at embryonic day (E) 18, whereas Rax expression in the pineal is relatively delayed and not detectable until E20. In both tissues, Rax is expressed throughout postnatal development into adulthood. In the mature rat pineal gland, the abundance of Rax transcripts increases 2-fold during the light period with a peak occurring at dusk. These findings are consistent with the evidence that Rax is of functional importance in eye development and suggest a role of Rax in the developing pineal gland. In addition, it would appear possible that Rax contributes to phenotype maintenance in the mature retina and pineal gland and may facilitate 24-h changes in ...
TY - JOUR. T1 - Identification of 11-cis-retinal and demonstration of its light-induced isomerization in the chicken pineal gland. AU - Sun, Jih Hsing. AU - Reiter, Russel J.. AU - Mata, Nathan L.. AU - Tsin, Andrew T.C.. PY - 1991/11/25. Y1 - 1991/11/25. N2 - Direct evidence is not available that (1) rhodopsin-like photopigment exists in the chicken pineal and that (2) the visual pigment is responsible for the light sensitivity of the gland. Therefore, the objective of this study was to test for the existence of visual pigment in the chicken pineal by means of the identification of 11-cis-retinal in this organ. 11-cis- and all-trans retinoids were extracted from light- and dark-adapted chicken pineals and analyzed by high performance liquid chromatography (HPLC) using the formaldehyde method. 11-cis-Retinal was initially identified by coelution with an authentic standard. Further characterization was carried out by collecting the retinal from the HPLC eluant, subjecting it to reduction by ...
The brain is a powerhouse for activity. There are so many things happening at once in your brain and some of them we dont even realize are going on. The brain governs all of the responses for our bodies and produces these responses as well. There are many different parts of the brain, and one part at the front of the brain is called the pineal gland. The pineal gland is called as such because from an anatomical view, it resembles a pine cone. The pineal glad regulates things like your sleep patterns as well as sexual hormones. The pineal gland is also known as the seat of the soul and is said to connect us with our extrasensory perception. In historic and biblical texts the pineal gland is referred to and is said to be the third eye which can open us up to enlightenment through connecting with our soul and to the rest of the universe. Seeing through the third eye, or pineal gland is not like seeing with your two other eyes, it gives you the ability to see within, to imagine, to have inner ...
Nicholls, J, Skene, DJ and Hourani, SMO (1997) Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin production ...
Editor, In5D.com. More and more people are wearing sunglasses, even if the sun is not shining bright and I see also that little children (toddlers) have sunglasses on. I remember an article by Dr. Ornstein in the Lets live Magazine in October 1980 were it is explained that Sunlight is very important, day light is very vital. The Creator provided for our emotional and physical health by giving us the Pineal Gland and commanding Let there be Light . The Pineal Gland is an active, secreting gland throughout life. Natural, unfiltered sunlight is necessary for the proper functioning of this gland. Light as conscious electromagnetic energy from the sun enters the body through the optic nerves of the eyes which, in turn, directly stimulates the pineal gland, a photo reactive organ. The pineal gland converts light energy into an electrochemical impulse which feeds directly into the hypothalamus.. ...
Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, NEUROSCIENCES, chicken, pineal gland, retina, circadian rhythm, light, melatonin, serotonin N-acetyltransferase, MELATONIN SYNTHESIS, PERCEIVED LIGHT, JAPANESE-QUAIL, CLOCK, SYSTEM, SUPPRESSION, RECEPTORS, CELLS ...
The pineal gland, also known as the pineal body, is an important endocrine gland that produces the hormone melatonin. Melatonin plays a key role in the sleep/wake cycle and the bodys respon
Just another morning taking shots of apple cider vinegar. This is how I keep my pineal gland clean & clear. The pineal gland: The pineal gland, also known as the pineal body, conarium or epiphysis cerebri, is a small endocrine gland in the vertebrate brain. It produces melatonin, a serotonin derived hormone, which affects the…
There are several treatment approaches for pineal region meningiomas, such as Poppens approach, Krauses approach and combinations of the two approaches. We present our experience with the use of 3D-computed tomography angiography for planning the surgical removal of pineal region meningiomas using a suboccipital transtentorial approach (Poppens approach) and evaluate the role of Poppens approach. During the period from January 2005 to June 2010, ten patients presented to us with pineal region meningioma. MRI was routinely used to define the tumor size, position, and its relevant complications while 3D-CTA was applied to define the blood supply of the tumor and the venous complex (VC) shift before operations. Most of the meningiomas had developed at both sides of the tentorial plane and extended laterally with typical characteristics of a pineal region tumor. All tumors were completely removed surgically without any injury to the VC. Postoperative intracranial infection occurred in one case who
There are several treatment approaches for pineal region meningiomas, such as Poppens approach, Krauses approach and combinations of the two approaches. We present our experience with the use of 3D-computed tomography angiography for planning the surgical removal of pineal region meningiomas using a suboccipital transtentorial approach (Poppens approach) and evaluate the role of Poppens approach. During the period from January 2005 to June 2010, ten patients presented to us with pineal region meningioma. MRI was routinely used to define the tumor size, position, and its relevant complications while 3D-CTA was applied to define the blood supply of the tumor and the venous complex (VC) shift before operations. Most of the meningiomas had developed at both sides of the tentorial plane and extended laterally with typical characteristics of a pineal region tumor. All tumors were completely removed surgically without any injury to the VC. Postoperative intracranial infection occurred in one case who
Introduction. The yak (Bos grunniens) is an important domestic animal on the Qinghai-Tibetan Plateau, where they number more than 13 million, constituting about 90% of the world yak population. Yaks are an important resource for farm products such as meat, milk, fibre and hides and they are also used as beasts of burden.. In most vertebrates, the pineal body is located on the roof of the diencephalon. It has nervous and endocrine properties (Jin et al. 2003). It secretes mainly melatonin at night and plays an important role in regulation of the seasonal reproductive function of animals and affects the age of sexual maturity in mammals (Lerner, Case & Takahashi 1960; Luboshitzky & Lavie 1999). Inclusion bodies in pinealocytes of the mammalian pineal gland have been described in man, as in other mammals, in previous studies (Calvo et al. 1988; Cozzi & Ferrandi 1984; Koshy & Vettivel 2001; Meyer-Arendt & Santamarina 1956). These inclusion bodies may represent nucleolus-like bodies (NLBs), mineral ...
Pinealocytes are the main cells contained in the pineal gland, located behind the third ventricle and between the two hemispheres of the brain. The primary function of the pinealocytes is the secretion of the hormone melatonin, important in the regulation of circadian rhythms. In humans, the suprachiasmatic nucleus of the hypothalamus communicates the message of darkness to the pinealocytes, and as a result, controls the day and night cycle. It has been suggested that pinealocytes are derived from photoreceptor cells. Research has also shown the decline in the number of pinealocytes by way of apoptosis as the age of the organism increases. There are two different types of pinealocytes, type I and type II, which have been classified based on certain properties including shape, presence or absence of infolding of the nuclear envelope, and composition of the cytoplasm. Type 1 pinealocytes are also known as light pinealocytes because they stain at a low density when viewed under a light microscope ...
Succinate dehydrogenase activity was investigated histochemically in the rat pineal gland. The influence of fixation on the activity pattern, the possible diffusion of enzyme, the nothing...
Cellular Basis of Pineal Gland Development: Emerging Role of Microglia as Phenotype Regulator[3] The adult pineal gland is composed of pinealocytes, astrocytes, microglia, and other interstitial cells that have been described in detail. However, factors that contribute to pineal development have not been fully elucidated, nor have pineal cell lineages been well characterized. ...The pineal gland begins as an evagination of neuroepithelium in the roof of the third ventricle. The pineal primordium initially consists of radially aligned Pax6+ precursor cells that express vimentin and divide at the ventricular lumen. After the tubular neuroepithelium fuses, the distribution of Pax6+ cells transitions to include rosette-like structures and later, dispersed cells. In the developing gland all dividing cells express Pax6, indicating that Pax6+ precursor cells generate pinealocytes and some interstitial cells. The density of Pax6+ cells decreases across pineal development as a result of cellular ...
Hi how are you. I just joined this site a couple of months ago that that is why I didnt write to you sooner. Okay now the pineal gland has many different ways of opening the basic ways are through meditation yoga and relaxation however those ways have never worked for me. When I was 16 years old I got hit by a car and I died for 8 minutes that opened up my pineal gland 100% it has been open ever since those things that you read about online about the headaches and the itching thats the pineal gland actually getting bigger. Thats why its causing the brain to react to it in that way. You can only go so far with guided meditation. If youve gotten that far through meditation your best bet is to start mixing something thatll make your body physically go down in heart rate. Or to basically take the mind off the body nuerologically. Not something detrimental to your health, something in the lines of marijuana or mushrooms. I would not recommend the usage of LSD unless you have supervision. ...
TY - JOUR. T1 - Growth patterns for acervuli in human pineal gland. AU - Kim, Jinkyung. AU - Kim, Hyun Wook. AU - Chang, Soeun. AU - Kim, Jee Woong. AU - Je, Jung Ho. AU - Rhyu, Im Joo. N1 - Funding Information: This work was supported by the Creative Research Initiatives (Functional X-ray Imaging) of MEST/NRF. I.J. Rhyu acknowledges the support from Korea University.. PY - 2012. Y1 - 2012. N2 - Acervuli are calcified concretions in the pineal gland (PG). Particularly interesting are their incidence and size, which are believed to affect neurological disorders and many physiological functions of PG such as regulating circadian rhythm. Despite long investigations for a century, detailed growth mechanism of acervuli has yet to be studied. Here we study the growth morphology of acervuli in human PGs by a direct visualization in 3-dimension (3-D) using a synchrotron X-ray imaging method. For an entire PG, non-aggregated acervuli show Gaussian distribution in size with 47±28 μm. The 3-D volume ...
OBJECTIVES This study was performed to search for changes in rat pineal function attributed to age and immunization with Freunds adjuvant. METHODS Young (2 months) and old (18-20 months) Wistar rats were injected s.c. with Freunds adjuvant or its vehicle. Eighteen days later, at the acute phase of arthritis, pineal concentration of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), norepinephrine (NE) and melatonin was measured by high pressure liquid chromatography at 4 different time intervals throughout the nocturnal activity span. RESULTS Old rats had the lowest pineal 5-HT and 5-HIAA content, the decrease in 5-HIAA exceeding that of 5-HT; consequently, old rats had the lowest 5-HIAA/5-HT ratio, an index of pineal 5-HT turnover. Although immunization did not affect globally pineal 5-HT or 5-HIAA levels, significant interactions immunization x age and immunization x time were found, i.e., immunization augmented pineal 5-HT content at the beginning of the activity span in young rats and
Assessment of presentation, imaging, and markers for diagnosis: Neuroimaging studies often enable differentiation of pineal teratomas from other tumors due to their distinct and characteristic radiographic appearance. Neuroimaging studies may also be diagnostic for pineal germinomas in teenage males with negative tumor markers. Patients with germinomas or NGGCTs may also have an elevated serum β-HCG level, in which case chemotherapy may also be recommended, in addition to radiation therapy, without surgical biopsy. Solid double tumors in the anterior and posterior third ventricle are considered a malignant germ cell tumor (germinoma or NGGCT) requiring chemotherapy followed by radiation, and may be diagnosed without tissue biopsy. Infants and preschool-age children are rarely diagnosed with germ cell tumors. In these patients the most common tumor of the pineal region is pineoblastoma, and therefore craniotomy for tumor resection is advised. ...
The pineal gland hangs on the brain behind its very center. French 18th century scientist Rene Descartes thought that the pineal gland was the core of the
CONCLUSIONS: It appears likely that changes in pineal melatonin production cannot be correlated directly with the effects of pinealectomy on the crypts, although melatonin production was not measured in this case. The role of loss of the non-adrenergic innervation of the pineal in the effect of pinealectomy needs to be examined. There is also other experimental evidence that melatonin-free extracts of the pineal, containing as yet unidentified substances, can influence mitotic activity in some tissues, so the possible role of these substances in the effects of pinealectomy should also be considered. Furthermore, the superior cervical ganglion itself has an extra-pineal role. Changes in pineal sympathetic innervation are not significant in the hyperproliferative effects of pinealectomy on the intestinal crypts..... Read abstract Full text PDF ...
Pineal tumors arise in the region of the pineal gland. This gland is a small structure deep within the brain. Treatment Surgery is essential to ...
In vertebrates, the essential amino acid L-tryptophan is the precursor of 5-methoxyindoles, or indolamines/tryptamines, including melatonin (N-acetyl-5-methoxytryptamine), through the intermediate serotonin (5-HT, 5-hydroxytryptamine) and the activity of hydroxyindole-O-methyltransferase (HIOMT) [14]. In mammals, melatonin is synthesized in the pineal gland, predominantly during the night-time, although it can be also produced in other organs, such as retina, gastrointestinal tract, lymphocytes and bone marrow cells. Conversely, light at night has an inhibitory effect on pineal melatonin biosynthesis which is initiated by the uptake of tryptophan from the circulation into pinealocytes [15]. Once synthesized, melatonin is not stored in the pineal cells, but it is released into the bloodstream with a circadian rhythm, from which it reaches other body fluids, including urine, saliva, cerebrospinal fluid, bile, semen and amniotic fluid [16, 17]. The circadian rhythm of melatonin secretion is ...
On the surface level, the Pineal gland, shaped like a pinecone, is at the geometric center of our brain and is intimately entwined with our perception of light. The pineal gland modulates circadian rhythms, and thus how we sleep. It remains uniquely isolated from the blood-brain barrier system, yet receives a higher percentage of blood flow than any other organ of the body except the kidneys. The pineal gland is tiny - smaller than a dime - located at the back of the roof of the third ventricle of the brain. (The ventricles are parts of the brain filled with cerebrospinal fluid (CSF), which act to maintain the optimum chemical environment for the central nervous system cells). The pineal becomes steadily calcified with age, starting most often before puberty, meaning it shows up clearly on skull X-rays and CT scans to allow identification of the midline.[3] ...
The pineal gland is present in all lower vertebrae. In other species, like birds, reptiles and frogs, the pineal gland is called the parietal eye or third-eye as its functions closely resemble that of an actual eye. In these other species, the pineal gland has components of an actual eye, with a cornea, rod and cone. It is considered to be the vestige of a functional sense organ of early primitive vertebrates.. Directly affected by the light taken in through the eyes, the pineal regulates sleep, menstrual cycles, mating seasons, hibernation, seasonal flight patterns and many other instinctual behaviors.*1. Tryptamine trippiness. Psychedelic researcher Dr Rick Strassman has explained how the pineal gland is quite active in synthesizing compounds related to serotonin, an important neurotransmitter in the brain. Neurotransmitters are the chemical messengers allowing communication among individual nerve cells. Most typical psychedelic drugs, such as LSD, mescaline, psilocybin, and DMT are ...
Your pineal gland, part of the endocrine system in your brain, plays a key role in regulating almost every function in your body, including reproduction, executive function, growth, body temperature, blood pressure, sensory and motor activity, sleep, mood, immune function, appetite, and longevity. The pineal gland sits in the epithalamus located beneath the cerebral cortex where the two […] ...
The primary function of the pineal gland is to secrete melatonin, which plays a role in regulating sleep cycles and in sexual development. The pineal gland also helps to regulate endocrine functions...
A pineal gland cyst is a usually benign (non-malignant) cyst in the pineal gland, a small endocrine gland in the brain. Historically, these fluid-filled bodies appeared on 1-4% of magnetic resonance imaging (MRI) brain scans, but were more frequent at death, seen in 21-41% of autopsies. A 2007 study by Pu et al. found a frequency of 23% in brain scans (with a mean diameter of 4.3 mm). It was once believed that smaller cysts (less than 5.0 mm) were usually asymptomatic, but for larger cysts (greater than 5.0 mm), symptoms could include headache, unexpected seizures, visual disturbances, memory loss, cognitive decline, muscle fasciculations, nausea, weakness, fatigue, light sensitivity, tinnitus, circadian rhythm dysfunction, or hydrocephalus if the cyst impinged on the superior colliculi or caused obstruction of the cerebral aqueduct. Newer research shows that the size of the cyst does not necessarily correlate to the presence of symptoms. In some cases, it will need to be removed before ...
From the Melanated Man: Just the facts on this post, no preaching today folks! (lol) Mentioned in the Melanin Production post, the pineal gland is where the production of melanin takes place, inside and outside your body. Also mentioned is the fact that the pineal gland needs SUNLIGHT, which is mainly received through the retina…
How you think and feel every day depends on the pineal gland Dr. Edward Group | Global Healing Center The famous philosopher Descartes described the pineal gland as the
Cleaning up the Pineal Gland is useful for those wishing to develop their multidimensional perceptio... Cleaning up the Pineal Gland is useful for those wishing
Because Cyp17a1 expression level was increased in the theca interna and interstitial cells in pinealectomized rats receiving vehicle, melatonin may influence CYP17A1 expression and steroidogenesis in the ovaries.
Rats exposed for 3 weeks to uniform 60-Hz electric fields of 39 kV/m (effective field strength) failed to show normal pineal gland circadian rhythms in serotonin N-acetyl transferase activity and melatonin concentrations. The time required for recovery of the melatonin rhythm after cessation of field exposure was determined to be less than 3 days. The rapid recovery suggests that the overall metabolic competence of the pineal is not permanently compromised by electric-field exposure, and that the circadian rhythm effect may be neuronally mediated. ...
Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. Decreased calcium ion availability is the si
THE PINEAL GLAND (also called the pineal body, epiphysis cerebri, epiphysis or the third eye) is a small endocrine gland in the vertebrate brain. It produces the serotonin derivative melatonin, a hormone that affects the modulation of wake/sleep patterns and seasonal functions. Its shape resembles a tiny pine cone (hence its name), and it is…
The pineal gland has various names such as pineal body, epiphysis cerebri, epiphysis or the third eye. It is believed that it connects our soul to our body.
Abstract: : Purpose:Mutations in several genes with expression limited to the photoreceptors and pinealocytes, such as the cone-rod homeobox gene (CRX), peripherin/RDS, and the gene encoding the aryl-hydrocarbon receptor interacting protein (AIPL1), are known to cause inherited retinopathy. Patients with mutations in these genes frequently cite secondary symptoms such as severe sleep abnormalities, or insomnia, but these complaints are often dismissed as due to limited physical activity in blind individuals. Due to the embryological, structural, and functional relationship of the photoreceptors and pinealocytes, it is possible that mutations causing photoreceptor degeneration in these patients might impact pineal function, resulting in abnormal circadian entrainment and these secondary symptoms. However, it is unknown how many retinopathy genes are also pineal-expressed or how many patients could be affected; therefore, we sought to determine which of the known retinopathy genes are pineal ...
The goals for surgery in this region may be gross total resection, biopsy alone, or reestablishment of cerebrospinal fluid flow. During preoperative planning, I consider the goals of the surgery based on the size and location of the tumor and its invasion of the neurovascular structures.. Of course, the surgeons experience and comfort level with various approaches are imperative in operative planning. In addition, the texture of the tumor (soft and suckable versus firm and vascular) must be considered in the decision to proceed with a particular approach. Firm and vascular tumors require wider operative corridors.. Two methods that are most commonly chosen to access the posterior third ventricle/pineal area are the supracerebellar-infratentorial route and the occipital interhemispheric-transtentorial route. I have predominantly used the infratentorial supracerebellar pathway because of its minimal disruption of the normal anatomy. I do not prefer the occipital interhemispheric transtentorial ...
Inhibition of synthesis of the pineal neurohormone melatonin (MEL) in mice, by administration of propranolol (PRO) in the evening, and daily injections of p-chlorophenylalanine (PCPA), resulted in a significant depression of the primary antibody response to sheep red blood cells (SRBC). Spleen cells from these mice showed a reduced reactivity against antigens in the autologous mixed lymphocyte reaction (AMLR). In contrast, alloreactivity remained normal. Reconstitution of the night-time peak of plasma MEL by evening injections to the mice completely reversed the suppression of the humoral response and the AMLR. MEL administration was able to antagonize the depression of antibody production induced by corticosterone in vivo. These results suggest that the pineal gland has important immunomodulatory functions through its cyclic, circadian release of MEL.
My husband was diagnosed of pineal cyst, and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, he had weakness of the body , and he always complain of ringing in ears (tinnitus) and headache . we tried various therapies prescribed by our neurologist but none could cure him.one faithful day i decided to go for a researched and i saw a testimony by someone who was cured and so many other with similar brain problem, and he left the contact of the doctor who had the cure to pineal cyst. I never imagine pineal cyst has a cure not until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one months time he was fully okay even up till this moment he is so full of life. pineal cyst has a cure and it is a herbal cure contact the doctor for more info on [email protected] on how to get the medication. Thanks for reading my testimony. ReplyDelete ...
My husband was diagnosed of pineal cyst, and it was really tough and heartbreaking for me because he was my all and the symptoms were terrible, he had weakness of the body , and he always complain of ringing in ears (tinnitus) and headache . we tried various therapies prescribed by our neurologist but none could cure him.one faithful day i decided to go for a researched and i saw a testimony by someone who was cured and so many other with similar brain problem, and he left the contact of the doctor who had the cure to pineal cyst. I never imagine pineal cyst has a cure not until i contacted him and he assured me my husband will be fine. I got the herbal medication he recommended and my husband used it and in one months time he was fully okay even up till this moment he is so full of life. pineal cyst has a cure and it is a herbal cure contact the doctor for more info on [email protected] on how to get the medication. Thanks for reading my testimony. ReplyDelete ...
The pineal gland is the least known of all the endocrine glands. The pineal isnt an actual gland; its a neuroendocrine transducer: meaning it conver
Entrainment of circadian clocks to environmental cues such as photoperiod ensures that daily biological rhythms stay in synchronization with the Earths rotation. The vertebrate pineal organ has a conserved role in circadian regulation as the primary source of the nocturnal hormone melatonin. In lower vertebrates, the pineal has an endogenous circadian clock as well as photoreceptive cells that regulate this clock. The zebrafish opsin protein Exo-rhodopsin (Exorh) is expressed in pineal photoreceptors and is a candidate to mediate the effects of environmental light on pineal rhythms and melatonin synthesis. We demonstrate that Exorh has an important role in regulating gene transcription within the pineal. In developing embryos that lack Exorh, expression of the exorh gene itself and of the melatonin synthesis gene serotonin N-acetyl transferase 2 (aanat2) are significantly reduced. This suggests that the Exorh protein at the cell membrane is part of a signaling pathway that positively regulates ...
The pineal gland is a bit of cone shaped gland which is hidden away deep in the human brain. Although its a small gland, it plays a really crucial role in The aging and melatonin production process
✅ Answered - [Control sexual behaviour] [Regulate period of puberty] [All the above] are the options of mcq question Function of pineal body is to realted topics , Chemical Coordination and Regulation, Chemical Coordination and Regulation, Chemical Coordination and Regulation topics with 0 Attempts, 0 % Average Score, 3 Topic Tagged and 0 People Bookmarked this question which was asked on Feb 23, 2019 22:24
ICD-10-PCS code 0G913ZZ for Drainage of Pineal Body, Percutaneous Approach is a medical classification as listed by WHO under the range - Endocrine Sy
The pineal gland is a tiny organ in the brain that produces the hormone melatonin, a substance that helps control our sleeping and waking cycle. Pineal tumors form in or near the pineal gland. There are several different kinds and grades.
Fluoride doesnt calcify the pineal gland.It does the opposite. Fluoride fluoridates the pineal gland. Atom Bergstrom talks about shielding the pineal gland in this blogpost.
Pineal glands secrets melatonin and various proteins and peptides which has many physiological functions. In keeping with this view, present experiment was conducted to know the effect of buffalo (Bubalus bubalis) pineal proteins (PP) at different dose level on fluoride-induced changes in plasma biochemicals and blood antioxidants enzymes in female rats. For this, we took 30 adult female Wistar rats (133-145 g body weights, BW) and divided into five groups (control, group I; 150 ppm fluoride (F), group II; F+ 50 µg pineal proteins, group III; F+ 100 µg PP, group IV; F+ 200 µg PP, group V). We administered fluoride (150 ppm, drinking water) and F+ pineal proteins at 50, 100, and 200 µg/kg BW, i.p. daily for 21 days. Blood samples were collected at the end of the experiments to estimate plasma glucose, proteins, F, lipid peroxidation (LPO), alkaline phosphatase (ALP), and acetyl cholinesterase (AChE) activity. Red blood cells (RBCs) were separated for analysis of LPO, AChE, catalase (CAT), ...
TY - JOUR. T1 - Antigonadal Effect of Melatonin in Pinealectomized and Intact Male Hamsters. AU - Turek, Fred W.. N1 - Funding Information: This investigation was supported by NSF Research Grant PCM-09955, NIH Grant 09885, and by a grant from the Office of Research and Sponsored Programs, Northwestern University. 5 1977 155 1 31 34 PY - 1977/5. Y1 - 1977/5. N2 - The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules inhibited photic-induced testicular recrudescence to the same degree in both pinealectomized and intact hamsters. Melatonin (300 μg/day) also induced marked testicular regression in sexually mature intact and pinealectomized hamsters maintained on a photostimulatory LD 14:10 light cycle. The similar responses of pinealectomized and intact hamsters to melatonin treatment indicate that the effects of exogenous melatonin are not mediated via the pineal gland.. AB - The administration of mela-tonin (12-150 μg/day) via subcutaneous Si-lastic capsules ...
Serotonin N-acetyltransferase complex. Molecular model of a complex formed between the serotonin N-acetyltransferase enzyme (AANAT, light blue, light red) and the zeta isoform structure of a 14-3-3 protein (yellow, green). AANAT is the penultimate enzyme involved in the conversion of serotonin to melatonin in the cells of the pineal gland in the brain. Melatonin modulates the function of the circadian clock, influencing activity and sleep. AANAT is rapidly inactivated when animals are exposed to light at night and therefore controls the rhythm of melatonin production. - Stock Image C035/8649
Pineal organ is a small endocrine organ present in the vertebrate brain also known as the third eye. It produces a hormone known as melatonin which regulates the sleep-wake cycle as well as seasonal functions of vertebrates. Melatonin is a serotonin subordinate. It is a reddish-dim substance resembling a minor pine cone fit as a fiddle. It is found rostro-dorsal to the superior colliculus just behind and underneath the striamedullaris, between the thalamic bodies. Pineal organ is a piece of epithalamus. It is a calcified part of brain that can be easily seen in plain X-beam. In people it is comprised of a lobular parenchyma of pinealocytes surrounded by connective tissue spaces. The organs surface is secured by a pial capsule. Pinealocytes structure the greatest main part of this organ yet different types of cells are also present that contrast in their cellular details.. CAUSES. Five types of cells that vary in their cellular structures are found in the pineal organ. Pinealocytes are the most ...
A pinealomas is a type of brain tumor that affects the pineal gland. There are many types of pinealomas, and not all of them are cancerous. Well list the different types and go over some common symptoms of pineal tumors, including precocious puberty. Youll also learn how theyre diagnosed and treated.
Melatonin is a natural hormone nutrient that is synthesized from the amino acid tryptophan by the pineal gland in the back of the brain. In the body, melatonin appears to regulate sleep/wake cycles, support normal immune function, and protect cells from free radical damage.. Most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in the dark, the bodys melatonin production rises. The rise in plasma melatonin is thought to be responsible for bringing on sleep. Nocturnal melatonin production is highest in children and begins to decline from adolescence or until it is virtually absent in the elderly.. Melatonin is considered a potent antioxidant that enters all body cells to help prevent free radical damage. In the brain, melatonin is perhaps the most important physiological antioxidant. Due to its lipid and watersoluble ...
View Notes - 8-30-11Limbic_BG from PSYCH 310 at Iowa State. Thalamus Mammilary body Hippocampus Red nucleus Hippocampus M & L geniculate Pineal body Pulvinar
Melatonin is a neurohormone secreted by the pineal gland and excreted by the urinary tract. It has a key role in the synchronisation of circadian rhythms including the sleep wake cycle, with a peak secretion around 03:00.. The neural pathway controlling melatonin secretion is long and transits via the thoracic spine. The exact level is not known, but interruption of the connection in patients with lesions of the spinal cord is known to occur.. Tetraplegic patients often complain of insomnia, daytime sleepiness and poor sleep quality but the contribution of melatonin levels to sleep quality has not been explored in large studies, although case reports have shown reduced or abolished melatonin secretion and altered melatonin secretion profiles with delayed peak secretion. Paraplegic patients report fewer sleep difficulties and little is known about melatonin secretion in this group. The investigators hypothesize that sleep abnormalities are related to abnormalities in melatonin secretion and that ...
The pineal gland, until recently, has been referred to as mystery gland, since its functions were largely unknown. The pineal is now recognized as a key element in the maintenance of the bodys endocrine regulation (hormone balance), immune system integrity, and circadian rhythm (daily metabolic balance). Melatonin is the principal hormone produced by the pineal gland. Melatonin is under investigation as a treatment for a number of conditions, including jet-lag, seasonal affective disorder (SAD), depression, and cancer. Pineal polypeptide extract (which contains a broad spectrum of other, protein-based pineal hormones) has been shown to inhibit the development of atherosclerosis [Tasca, et al., 1974], reduce blood triglyceride levels [Ostroumova and Vasiljeve, 1976], improve cellular immunity [Belokrylov, et al., 1976; Dilman, 1977], and increase lifespan in animals [Dilman, et al., 1979]. The pineal gland functions as a biological clock by secreting melatonin (along with many other ...
Abstract: The objective of this study was to apply the radioimmunoassay for 6-sulphatoxymelatonin (aMT6s) to rat urine, and use it to study the source of aMT6s. The radioimmunoassay was found to have acceptable within- and between-assay variation, excellent specificity, and good parallelism between the standard and unknown. Because urine is highly contaminated we assessed whether preliminary purification was required and established that it was unnecessary. Using this assay a 24-hr rhythm in 6-sulphatoxymelatonin output was seen in pools of urine harvested at 3-hr intervals from Wistar rats on LD 12:12. The nocturnal rise in aMT6s was abolished by constant light. In contrast pinealectomy lowered aMT6s output significantly throughout both dark and light. This study confirms previous studies indicating that the pineal is the major source of 6-sulphatoxymelatonin. It is concluded that urinary 6-sulphatoxymelatonin as measured by radioimmunoassay is a valid measure of pineal gland activity in the ...
Will anything tangible ever culminate from this dense pressure/vibration sensation in my pineal gland area? - Mystic Banana - New Age Spirituality Magazine
A 45-year-old man presented to us with headache and vomiting for15 years ago. He was diagnosed as having obstructive hydrocephalus due to a pineal region tumour. A ventriculoperitoneal shunt was inserted to relieve hydrocephalus with symptomatic relief. He was followed up with regular MRI scans. Serial imaging showed slow progression in tumor size when he was 60 years old. Neurological examination revealed Parinaud sign with upward gaze palsy. The MRI with gadolinium showed an mildly enhancing lobulated tumor in the region of the superior tectum measuring 22.5mm x 21mm x 20mm (Figs. 1 and 2). The lesion at the superior tectum and the pineal region showed heterogeneous T1-hyperintense signal on precontrast images (Fig. 1). It exhibited very slow growth, with a gradual increase in size over 15 years. There was mild mass effect to the cerebral aqueduct with indentation of the pineal gland (Fig. 3). However, there was no hydrocephalus at that time. In view of symptomatic progression of tumor size, ...
H Aguchi, K I Kato, and H Ibayashi, Age-dependent reductions in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metabolism 55: 27-29, 1982.. J Beck-Friis, D Von Rosen, B F Kjellman, J G Ljunggren and L Wetterberg, Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuroendocrinology 9: 261-278, 1984.. I N Ferrier, J Arendt, E C Johnstone and T J Crow, Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight. Clinical Endocrinology 17: 181-87, 1982.. G J M Maestroni, A Conti, and W Pierpaoli, Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effects of corticosterone. J Neuroimmunology 13: 19-30, 1986.. G J M Maestroni, A Conti, and W Pierpaoli, Role of the pineal gland in immunity. II. Melatonin enhances the antibody response ...
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Melatonin is a hormone that is produced by the pineal gland in the brain and production of melatonin follows the circadian cycle. When there is less light, receptors in the optic nerve send a message to the brain to notify it of chances in the circadian cycle. The brain then sends a message to the pineal gland to produce more melatonin in order to make us sleepy. The reverse works when there is more light and melatonin production slows down, resulting in us being more alert. Melatonin production naturally slows down with age, which is one of the reasons why many people struggle to sleep for long periods of time.. Some people who have trouble sleeping find that their bodies are producing low levels of melatonin. Although a naturally occurring substance in some food items, including bananas, tomatoes, barley and oats, many people opt to take melatonin supplements to help them combat sleep disorders such as jet lag and insomnia. Although it doesnt make you fall asleep, it promotes it by ensuring ...
PURPOSE: This study had three objectives: (1) to characterize the structures of the chicken GCAP1 and GCAP2 genes; (2) to determine if GCAP1, GCAP2, and GC1 genes are expressed in chicken pineal gland; (3) if GC1 is expressed in chicken pineal, to determine if the GC1 null mutation carried by the re ...
Together they express the great void at absolute peace with itself. To activate the third eye of Shiva, or to perceive higher dimensions, the pineal gland (seat of the soul) and the pituitary glands (body) must vibrate in resonance to create a field. This is represented by Samudra manthan in Hindu mythology, where Mount Meru is used to churn the oceans for Amrit or Ambrosia in a to and fro movement, representing vibrations. The amrit of the ambrosia or Soma is the holy grail. This is what the Templar knights got after excavating King Solomons temple. Soma is a divine LSD - rather a million times more powerful DMT. A 12 strand Maharishi with NIL junk DNA can produce it naturally, by resonating his pineal gland with his DNA, and achieve telepathy and psychic teleportation. The psychedelic journeys are accessed and experienced within the realms of the pineal gland. Serotonin has the same chemical structure as this hallucinogenic substance Soma. Serotonin is transformed into melatonin only in the ...
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Pineal melatonin, an endogenous signal of darkness, is believed to be an important regulator of circadian and seasonal rhythms. The changing melatonin levels serve as hands of a bio-clock and dates of the biocalendar in vertebrates including humans. Circulating melatonin regulates and influences the sleep wake cycle, sexual development, as well as various immune, endocrine, and metabolic functions. Initially it was thought to be produced exclusively by pineal gland. Subsequently, it was shown that melatonin is also produced in several other tissues. Substantial amounts of melatonin are found in the gut as well as the brain. Moreover, melatonin is one of the most powerful scavengers of free radicals. Sleep disorders and low melatonin levels are frequently observed in people with autism spectrum disorders (ASD). The role of abnormal melatonin biosynthesis in the gastrointestinal system relating to the development of ASD symptoms warrants further studies. The important multiple role of melatonin in ...
Sexual maturation in females occurred earlier in the high-fluoride animals (Luke 1997); males had increases in melatonin production relative to body weight between 11.5 and 16 weeks (when a decrease normally would occur), and testicular weight at 16 weeks (but not at 9 or 28 weeks) was significantly lower in high-fluoride than in low-fluoride animals. The circadian rhythm of melatonin production was altered in the high-fluoride animals at 11.5 weeks but not at 16 weeks. In high-fluoride females at 11.5 weeks, the nocturnal peak (relative to body weight) occurred earlier than in the low-fluoride animals; also, the peak value was lower (but not significantly lower) in the high-fluoride animals. In males, a substantial reduction (P , 0.00001) in the nocturnal peak (relative to body weight) was observed in the high-fluoride animals.. Although no studies are available that specifically address the effect of fluoride exposure on pineal function or melatonin production in humans, two studies have ...
Melatonin 500 mcg, 200 vegetarian capsules Melatonin releases from the pineal gland, reaching its peak at night to help maintain healthy cell division in tissues throughout the body. Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified. Jet lag, shift work, and poor vision can disrupt melatonin cycles. Melatonin keeps our circadian cycle in tune as it communicates with the bodys cells. Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration. As this hardworking hormone diminishes with age, our biological functions are impaired. In addition to its hormone actions, melatonin also has strong antioxidant properties. Melatonin directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants. Melatonin is especially important for protecting cellular
Melatonin 500 mcg, 200 vegetarian capsules Melatonin releases from the pineal gland, reaching its peak at night to help maintain healthy cell division in tissues throughout the body. Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified. Jet lag, shift work, and poor vision can disrupt melatonin cycles. Melatonin keeps our circadian cycle in tune as it communicates with the bodys cells. Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration. As this hardworking hormone diminishes with age, our biological functions are impaired. In addition to its hormone actions, melatonin also has strong antioxidant properties. Melatonin directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants. Melatonin is especially important for protecting cellular
Patients with familial/heritable retinoblastoma (RB) are at increased risk of developing second malignancies throughout life, including a pineoblastoma (trilateral RB [TRB]) in early childhood. Current guidelines recommend regular surveillance brain imaging for those with heritable RB until 5 years of age. The presence of pineal cysts has been reported in patients with RB. Pineal cysts are thought to arise due to focal degeneration of the pineal gland and can be found incidentally. The finding of pineal abnormalities including cysts in children with RB on imaging is disconcerting, as it raises the possibility of an underlying malignancy, specifically a pinealoblastoma ...
J Physiol. 2001 Aug 15;535(Pt 1):261-7. An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans.. Thapan K, Arendt J, Skene DJ.. Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK.. 1. Non-image forming, irradiance-dependent responses mediated by the human eye include synchronisation of the circadian axis and suppression of pineal melatonin production. The retinal photopigment(s) transducing these light responses in humans have not been characterised. 2. Using the ability of light to suppress nocturnal melatonin production, we aimed to investigate its spectral sensitivity and produce an action spectrum. Melatonin suppression was quantified in 22 volunteers in 215 light exposure trials using monochromatic light (30 min pulse administered at circadian time (CT) 16-18) of different wavelengths (lambda(max) 424, 456, 472, 496, 520 and 548 nm) and irradiances (0.7-65.0 microW ...
TY - JOUR. T1 - Melatonin provokes cell death in human B-lymphoma cells by mitochondrial-dependent apoptotic pathway activation. AU - Trubiani, Oriana. AU - Recchioni, Rina. AU - Moroni, Fausto. AU - Pizzicannella, Jacopo. AU - Caputi, Sergio. AU - Di Primio, Roberto. PY - 2005/11. Y1 - 2005/11. N2 - Apoptosis is an important cell suicide programme involved in physiological and pathological processes. Apoptosis can be induced in different ways depending on cell type and acquired signal. Melatonin, the major secretory product of the pineal gland, participates in many important physiological functions and displays a remarkable functional versatility exhibiting antioxidant, oncostatic, anti-aging, and immunomodulatory properties. Recently, it has been shown that, in addition to pineal gland, human lymphoid cells are an important physiological source of melatonin and that may be involved in the regulation of the immune system. In this work, we examine the effect of melatonin on RAMOS-1 human ...
This melatonin works like a charm for my better half. One or two of these an hour before she goes to bed and she sleeps like a baby. Interestingly one of these 1 mg. capsules works better for her than another brands 5 mg. melatonin capsule. And I love the fact that while its helping her sleep better, its also reducing her chances of getting cancer, protecting her brain in several different ways, and mopping up free radicals throughout her body. Several tips: (1) If you take it too late or take too much, youll still be drowsy when its time for you to wake up. Experiment with both the time you take it and the amount to see whats best for you. (2) Somewhere I read that varying the dose (not taking the same amount every night) keeps your pineal gland from reducing or shutting down its own production of melatonin. (3) Speaking of which, be sure to sleep in absolute darkness if you want your pineal gland to produce melatonin. (4) Experiment with very low doses. A study referenced in an article ...
Your pineal gland, part of the endocrine system in your brain, plays a key role in regulating almost every function in your body, including reproduction, executive function, growth, body temperature, blood pressure, sensory and motor activity, sleep, mood, immune function, appetite, and longevity. The pineal gland sits in the epithalamus located beneath the cerebral cortex where the two […] ...
The purpose of this study was to determine whether mammalian cells can utilize 2-fluoro-L-histidine in protein synthesis. Rat pineal glands were incubated in organ culture in medium containing 2-fluoro-L-[4-3]histidine (3 mM); trichloracetic acid-insoluble material from these glands contained radioactivity. Incorporation of radioactivity was decreased in the presence of histidine (3 mM). After the 3H-labeled macromolecules were treated with a protease, over 75% of the radioactivity was soluble in trichloracetic acid. Amino acid analysis of the trichloracetic acid-soluble material indicated that the majority of the liberated radioactivity was 2-fluoro-L-[3H]histidine. These findings demonstrate that mammalian cells can incorporate 2-fluoro-L-histidine into newly synthesized proteins. In view of this, it would appear likely that the reported inhibitory effects of 2-fluoro-L-histidine on enzyme induction could result, in part, from the incorporation of the analogue into proteins.. ...
Professor Karen Greifs lab has examined the normal patterns of development of synaptic molecules in the rat Central Nervous System (CNS) and in sympathetic ganglia. Much is known about the possible functions of synaptic vesicle proteins. The assembly and transport of these proteins to developing terminals will be examined. The purpose of this specific research project is to determine whether the proteins syntaxin and synaptotagmin are co-localized in developing synapses in the pineal gland of neonatal rats. A previous study in this lab has shown that synaptotagmin-yellow fluorescent protein (syt-YFP) is transported by axons prior to synapse formation in the pineal gland (Narayan and Greif, 2000, Soc Neurosci Abstr 2000; 26:301). Other evidence suggests that synaptic proteins are grouped together in axons before they reach their targets. Superior cervical ganglions (SCGs) of rats will be injected at postnatal day 1 and postnatal day 7 with the adenovirus syt-YFP construct. Animals will be kept
I am a disciple of Sri Paramahansa Yogananda. I am a Kriyavan. I had written three books with the intuitive guidance of Mahavatar Babaji during meditation. viz., 1) Creation Incarnation Sadhana in English, Shrishti Janma Sadhana in Hindi & Telugu and 2) Krishna Kriya Kaivalya - Kriyas for Samadhi & removal of all diseases in English, Krishna Kriya Kaivalya - Samadhi Sarvaroga Nivarinee Kriyas in Hindi & Telugu.3)JYOTISHYA VASTU RUDRAKSH CRYSTAL KUNDALINEE KRIYA YOGA is written in English & Telugu. I had constructed a Dhyanamandir and imparting the knowledge of Yoga Dhyana to the aspiring devotees free of cost. KM SASTRY, Dhyanamandir, Ramalayam St, DN76, Devinagar,RK Puram Gate, Hyderabad 500056, PH; 09440364947, Email: [email protected] You can send the amount on line to KM.Sastry,State Bank of India, DefencecolonyBr ,Br.code8025,SB A/c 10591477916, MICR No 500002042, ...
The 12 Foundation Stones in New Jerusalem - Crystals and the Bible February 4, 2015 Elasa Crystal Healing Facts, Crystals and the Bible, Crystals for Health 6. Have you ever wondered about the significance of the 12 foundation stones in New Jerusalem? In Revelation chapter 21, John describes seeing the new Jerusalem (heaven), and he goes into detail about the 12 foundation stones, the streets of pure gold and the pearl gates. If you have read my other articles, you know that each crystal and stone has its own unique vibration and healing properties. In this first installment of my Crystals and The Bible series, we are going to be taking a closer look into the meanings and properties of these 12 stones mentioned in the Bible. Revelation 21: 18-21. In Revelation chapter 21, God shows John the new Jerusalem. After describing the measurements of the holy city, John tells us about the precious stones garnishing the foundation of the wall.. 18 And the building of the wall of it was of jasper: and ...
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Image source: freedigitalphotos.net / khongkitwiriyachan. Optimize Melatonin and Reduce Breast Cancer Risk. Research indicates that low levels of melatonin are associated with an increased risk of breast cancer. In this article, I will share with you the role that melatonin plays, as well as 10 tips to optimize melatonin production, so you can get a better nights sleep and reduce your risk of breast cancer.. Melatonin Is A Natural Hormone. Melatonin is a natural hormone produced in the pineal gland of the brain, best known for its function with our sleep/waking cycles. Light inhibits the production of melatonin in your brain and alters your natural rhythms (called Circadian rhythms). Way back in 1976, a research project called the Nurses Health Study followed 121,701 female nurses for a number of years. Among other health issues, the study found that nurses who worked night shifts had a 36% higher risk of breast cancer. Since then, other studies have found a relationship between lack of sleep, ...
In Syrian hamsters exposed to SD lengths, low and high Ta may accelerate and delay the appearance of winter traits, respectively, by modulating the responsiveness of target tissue to melatonin. The amplitude of the melatonin signal does not consistently increase in Syrian hamsters housed at low temperatures: no differences were detected in plasma melatonin concentrations of males held at 5 and 20°C, respectively (31, 33), but in a third investigation (40), serum melatonin concentrations were higher at 5 than 22°C. It is unknown whether amplitude changes of the magnitude reported in the latter investigation affect rates of gonadal regression.. Cold exposure accelerated α-expansion, which presumably implies an earlier appearance of long-duration melatonin signals. This conclusion must remain tentative pending verification of the high positive correlation of these variables at low as well as higher Tavalues. In any case, the more rapid entrainment in cold-exposed hamsters was insufficient to ...
A meningioma, is an uncommon cause of pineal mass. As always it is important to remember that some conditions can occur in unusual places, and one should not limit a differential only to lesions which are characteristic of a particular region.
Common signs and symptoms of pineal gland tumors include nausea, double vision, vomiting and headache, American Brain Tumor Association states. The symptoms these tumors cause are largely due to...
Melatonin is an indolic hormone produced mainly by the pineal gland. The former hypothesis of its possible role in mammary cancer development was based on the evidence that melatonin down-regulates some of the pituitary and gonadal hormones that control mammary gland development and which are also responsible for the growth of hormone-dependent mammary tumors. Furthermore, melatonin could act directly on tumoral cells, as a naturally occurring antiestrogen, thereby influencing their proliferative rate. The first reports revealed a low plasmatic melatonin concentration in women with estrogen receptor (ER)-positive breast tumors. However, later studies on the possible role of melatonin on human breast cancer have been scarce and mostly of an epidemiological type. These studies described a low incidence of breast tumors in blind women as well as an inverse relationship between breast cancer incidence and the degree of visual impairment. Since light inhibits melatonin secretion, the relative ...
2017 Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC. (2017) Daily Rhythm in Plasma N-acetyltryptamine. https://www.ncbi.nlm.nih.gov/pubmed/28466676 J Biol Rhythms. 32(3):195-211.. doi: 10.1177/0748730417700458. Epub
Our research group has previously studied the role of melatonin in the immune system of birds and mice, finding that incubation with both pharmacological and physiological doses of melatonin augmented the activity of phagocytes from these animals, and that this activity was lowered in pinealectomized animals. Since melatonin is synthesized from the amino acid tryptophan, the aim of the present work was to determine whether the administration of tryptophan might affect the plasma levels of melatonin and the phagocytic activity of peritoneal macrophages over the course of a circadian cycle. The study animals were 14-week-old male Wistar rats. They were administered tryptophan orally in a daily single dose of 125 mg/kg at 19:00 h for 21 days. Prior to beginning this treatment, the circadian rhythms of plasma melatonin and phagocytic activity were evaluated under basal conditions over a 24-h period, taking blood and cell suspension samples each 2 hours during the light period (08:00-20:00) and each ...
Results: Melatonin levels in normotensive patients (IOP below 21 mmHg) presented values as medians (first quartile; third quartile) of 14.62 (5.38;37.99) ng/ml (n = 23), while hypertensive patients (IOP above 21 mmHg) showed melatonin concentrations of 46.63 (10.28; 167.28) ng/ml (n = 14; p , 0.039). Glaucoma mice presented melatonin values of 0.37 (0.34; 0.59) ng/ml (at 3 months of age, before the pathology starts), which increased to 1.55 (0.94; 1.88) ng/ml (at 12 months of age, when the pathology is fully developed and IOP is maximum; n = 6, p , 0.001). Control mice did not significantly modified melatonin concentrations between 3 and 12 months of age ...
Christie, Angela, Burgess, Anne P. and Sim, Edith (1987) N-Acetyltransferase activity in cultured-cells. Biochemical Society Transactions, 15(3), p. 449. ISSN (print) 0300-5127 ...
Inherent in all living organisms, natures circadian rhythm springs us into activity in the daytime and then into rest and restoration at night. And this circadian rhythm is attuned to the presence and absence of the sun, principally blue light.. Melatonin is critical to regulating the bodys circadian rhythm. When the sun goes down and it becomes dark, our eyes sense the absence of light and send a signal to the brain, which instructs the pineal gland to produce melatonin and put us to sleep.. Now in modern times, the incandescent light began humankinds earliest assault on natures circadian rhythm. This has only worsened with the advent of television, computers, tablets, cell phones, gaming stations and whatever else produces light to interfere with our circadian rhythm. When the lights stay on, melatonin production is slowed or stopped.. Exposure to sunlight - at least 10 to 15 minutes a day is recommended - is also crucial to the production of vitamin D, which is found in very few foods but ...
The timing of the daily onset of light and dark as well as the annual cycle of changes in the daily ratio of light to dark hours provide the most reliable and enduring signals for accurately estimating time of day and time of year. The ability to track time of day and time of year allows individuals to anticipate predictable events such as night or winter and make appropriate physiological adjustments in anticipation of these upcoming environmental changes. Light information is received by distinct retinal photoreceptors, sent to the suprachiasmatic nucleus (SCN) and then projected by efferent connections to the pineal gland; the pineal comparably synthesizes and secretes melatonin during the dark period (scotophase) in diurnal and nocturnal mammals. The circulating melatonin rhythm is suggested to play a major regulating role in the mammalian photoentrainment system (Pévet et al., 2006; Pandi-Perumal et al., 2008; Zawilska et al., 2009). The mammalian retina presents two distinctive classes of ...
The effects of poor lighting and glare on public safety are well-known, as are the harmful environmental effects on various species and the environment in general. What is less well-known is the potential harmful medical effects of excessive poor nighttime lighting. A significant body of research has been developed over the last few years regarding this problem. One of the most significant effects is the startling increased risk for breast cancer by excessive exposure to nighttime lighting. The mechanism is felt to be by disruption of the circadian rhythm and suppression of melatonin production from the pineal gland. Melatonin has an anticancer effect that is lost when its production is disrupted. I am in the process of developing a monograph that will summarize this important body of research, to be presented and endorsed by the American Medical Association, and its Council of Science and Public health. This paper is a brief overall summary of this little known potential harmful effect of poor ...
Melatonin is a hormone secreted by the pineal gland that aids biorhythm regulation.* Biorhythm is disrupted by stress, crossing time zones and changing work shifts.* Melatonin production also declines with age.* Vitamin B6 aids melatonin metabolism.* Keep out of the reach of children.