In mesial temporal lobe epilepsy (MTLE), spontaneous seizures likely originate from a multi-structural epileptogenic zone, including several regions of the limbic system connected to the hippocampal formation. In this study, we investigate the structural connectivity between the supramammillary nucleus (SuM) and the dentate gyrus (DG) in the model of MTLE induced by pilocarpine in the rat. This hypothalamic nucleus, which provides major extracortical projections to the hippocampal formation, plays a key role in the regulation of several hippocampus-dependent activities, including theta rhythms, memory function and emotional behavior, such as stress and anxiety, functions that are known to be altered in MTLE. Our findings demonstrate a marked reorganization of DG afferents originating from the SuM in pilocarpine-treated rats. This reorganization, which starts during the latent period, is massive when animals become epileptic and continue to evolve during epilepsy. It is characterized by an aberrant
RESULTS: A total of 4973 patients with new-onset pSS were eligible for analysis. After propensity score matching, we included 1014 patients in the pilocarpine group and 2028 patients in the non-user group. During the mean follow-up of 2.6 years, the number of events was 487 in the pilocarpine group (48.0%) and 1047 in the non-user group (51.6%); however, the difference was not significant (hazard ratio [HR] 0.93, 95% confidence interval [CI] 0.82 to 1.06). Furthermore, there was no significant difference between groups regarding risk of periodontitis (HR 0.91, 95% CI 0.81 to 1.03) and oral candidiasis (HR 1.16, 95% CI 0.70 to 1.94 ...
Antioxidant effects in vivo of ISO on pilocarpine-induced seizures. Post hoc comparisons showed that pilocarpine significantly increased LP levels in rat hippocampus when compared to the control group [p,0.0001]. Pretreatment with ISO at dose of 1.0 mg/kg protected against the increase of LP levels caused by pilocarpine in rat hippocampus (Table 3).. Post hoc comparisons showed that pilocarpine significantly increased RS levels in rat hippocampus when compared to the control group [p,0.0001]. Pretreatment with ISO at the dose of 1.0 mg/kg protected against the increase of RS levels caused by pilocarpine in rat hippocampus. ISO alone did not alter LP and RS levels when compared to the control group (Table 3).. Post hoc comparisons revealed that pilocarpine no altered CAT activity [p,0.0001]. The increase of CAT activity induced by ISO (1.0 mg/kg, i.p.) was observed in rat hippocampus treated with pilocarpine when compared to the control group (Table 3) [p,0.0001]. CAT activity remained increased ...
TY - JOUR. T1 - Spectroscopic imaging of the pilocarpine model of human epilepsy suggests that early NAA reduction predicts epilepsy. AU - Gomes, William A.. AU - Lado, F. A.. AU - De Lanerolle, N. C.. AU - Takahashi, K.. AU - Pan, C.. AU - Hetherington, H. P.. PY - 2007/8/1. Y1 - 2007/8/1. N2 - Reduced hippocampal N-acetyl aspartate (NAA) is commonly observed in patients with advanced, chronic temporal lobe epilepsy (TLE). It is unclear, however, whether an NAA deficit is also present during the clinically quiescent latent period that characterizes early TLE. This question has important implications for the use of MR spectroscopic imaging (MRSI) in the early identification of patients at risk for TLE. To determine whether NAA is diminished during the latent period, we obtained high-resolution 1H spectroscopic imaging during the latent period of the rat pilocarpine model of human TLE. We used actively detuneable surface reception and volume transmission coils to enhance sensitivity and a ...
Neutral Pilocarpine information about active ingredients, pharmaceutical forms and doses by Pharmatel, Neutral Pilocarpine indications, usages and related health products lists
Pilocarpine has been used in the treatment of chronic open-angle glaucoma and acute angle-closure glaucoma for over 100 years.[3] It acts on a subtype of muscarinic receptor (M3) found on the iris sphincter muscle, causing the muscle to contract and engage in miosis. Pilocarpine also acts on the ciliary muscle and causes it to contract. When the ciliary muscle contracts, it opens the trabecular meshwork through increased tension on the scleral spur. This action facilitates the rate that aqueous humor leaves the eye to decrease intraocular pressure. Pilocarpine is often used as an antidote for scopolamine, atropine, and hyoscyamine poisoning. In ophthalmology pilocarpine is also used to reduce the possibility of glare at night from lights if the patient underwent implantation of phakic intraocular lenses; the use of pilocarpine would reduce the size of the pupils, relieving these symptoms. The most common concentration for this use is pilocarpine 1%, the weakest concentration. Pilocarpine is also ...
Sjögrens syndrome is an autoimmune disease that affects exocrine glands and causes keratoconjunctivitis sicca. Ocular complications include corneal ulceration, episcleritis, keratitis, and bacterial or viral infection. The use of artificial tears is the mainstay of treatment. It has been suggested that pilocarpine, a cholinergic parasympatheticomimetic agonist, might improve the symptoms of keratoconjunctivitis sicca. Researchers in Greece have used oral pilocarpine with good effect.. Eighty five women (mean age 58 years) with Sjögrens syndrome were randomised to 12 weeks treatment with oral pilocarpine 5 mg twice daily plus artificial tears, artificial tears only, or occlusion of the inferior lachrymal puncta plus artificial tears. Changes in symptoms were assessed on a 100 mm visual analogue scale (VAS). Symptom improvement was 90% (pilocarpine) v 30% (artificial tears only), v 60% (punctal occlusion). Improvement with pilocarpine was significantly better than with punctal occlusion ...
Discussion. Topical pilocarpine 2% is a parasympathomimetic drug with direct cholinergic action on the muscarinic receptors and smooth muscles of the iris and ciliary body. This drug causes the contraction of the pupil by increasing the tension in the scleral spur and providing the opening of the spaces of the trabecular meshwork. It is traditionally used to reduce the intraocular pressure in the treatment of glaucoma,(1) and for increased salivation in patients with Sjogrens Syndrome.(2) Recent articles show the use of topical pilocarpine for pupillary manipulation in order to reduce the positive and negative dysphotopies in pseudophakic patients in the postoperative cataract surgery.(3,4) The effect of pilocarpine for this purpose comes from the miosis and creation of a pupillary pinhole excluding the peripheral rays in the formation of the image and improving the depth of focus. As the central light rays suffer less aberrations, they provide greater sharpness of the images formed. In cases ...
What happens if I miss a dose: Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed. Do not give a double dose of this medication.. What happens if I overdose the pet: Flush the pet¿s eye with water and seek emergency veterinary medical attention. Symptoms of a pilocarpine ophthalmic overdose may include vomiting, diarrhea, increased salivation, watering mouth, and tearing eyes.. What should I avoid while using Pilocarpine: Pilocarpine Ophthalmic may cause decreased vision in poor light. Do not touch the dropper tip to any surface, including your eyes and hands. The dropper tip is sterile. If it becomes contaminated, it could cause an infection in the pet¿s eye. Avoid other eye medications unless your veterinarian approves.. Possible side effects of Pilocarpine: Rarely, pilocarpine ophthalmic may cause retinal detachment. Retinal detachment can lead to blind spots, floaters in ...
All experiments were approved by the Stanford University Institutional Animal Care and Use Committee and performed in accordance with National Institutes of Health Guide for the Care and Use of Laboratory Animals. Pilocarpine treatment was performed as described previously (Buckmaster, 2004a). Briefly, male Sprague Dawley rats (34 ± 1 d old; range 27-45) were treated with atropine methylbromide (5 mg/kg, i.p.), then 20 min later with pilocarpine hydrochloride (380 mg/kg, i.p.) to induce status epilepticus. All chemicals were from Sigma-Aldrich unless specified otherwise. After 2 h of status epilepticus, convulsions were suppressed with diazepam (10 mg/kg, i.p., repeated as needed; Hospira), and lactated Ringers solution was administered subcutaneously. All rats in this study experienced at least 2 h of status epilepticus.. Osmotic pumps and cannulae were implanted to focally and continuously deliver rapamycin (Alexis Biochemicals or LC Laboratories) to the dorsal, left dentate gyrus. Rats were ...
Timpilo information about active ingredients, pharmaceutical forms and doses by Merck, Timpilo indications, usages and related health products lists
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy. Copyright © 2016 CancerConnect Last updated 07/10.. Important Limitations of Use. The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information ...
Sjögrens syndrome is a systemic immune disease with impaired secretion of salivary glands; thus, it may cause inconvenience in patients daily lives. Pilocarpine is a non-selective muscarinic receptor agonist used to treat dry mouth. This single-arm intervention, post-market surveillance study evaluated the safety of pilocarpine (Salicret, Meider Pharmaceutical Co., Ltd.) for treating Sjögrens syndrome. We recruited 135 patients with Sjögrens syndrome who received pilocarpine orally four times daily at a dose of 5 mg for 24 weeks. Forty-one (31.3%) of 131 patients experienced at least one adverse event (AE), and of those, 37 patients (28.2%) AEs were associated with the study treatment. The most common drug-related AEs were sweating in 14 patients (10.7%) and palpitation in 9 (6.9%). No serious AEs occurred during the study period. Therefore, pilocarpine therapy is considered effective, safe, and well tolerated in patients with Sjögrens syndrome.
10 eyes (10 subjects; mean age, 55±12 years; mean intraocular pressure, 14.2±3.5 mmHg) were included. All horizontal scans were ~1-2 mm away from the LI site. Mean AOD, ARA, TISA and TIA of the 4 quadrants increased from baseline after pilocarpine and after LI (baseline vs. post-pilocarpine, all p,0.036; baseline vs. post-LI, all p,0.001), but the increase was greater after LI than after pilocarpine although statistically insignificant (post-pilocarpine vs. post-LI, all p,0.200) (Table 1). In the temporal quadrant, mean AOD, ARA, TISA and TIA increased from baseline after piloparpine and after LI (baseline vs. post-pilocarpine, all p,0.043; baseline vs. post-LI, all p,0.001), but the increase was significantly greater after LI than after pilocarpine (post-pilocarpine vs. post-LI, all p,0.019) (Table 1). In the superior, inferior and nasal quadrants, all angle parameters were similar between post-pilocarpine and post-LI (all p,0.106). ACD decreased and LV increased after pilocarpine from ...
Looking for Closed-angle glaucoma? Find out information about Closed-angle glaucoma. ocular disorder characterized by pressure within the eyeball caused by an excessive amount of aqueous humor . This causes pressure against the optic nerve... Explanation of Closed-angle glaucoma
Pilocarpine nitrate salt chemical properties, What are the chemical properties of Pilocarpine nitrate salt 148-72-1, What are the physical properties of Pilocarpine nitrate salt ect.
To treat any underlying infection.. Artificial tears (Refresh®, Celluvisc®, Hylashield®) can be used to substitute tears, but literally must be instilled every 30-60 minutes if used as sole therapy for dry eyes. This not only is impractical, but also not necessary for our patients. Use artificial tears as adjunctive therapy for KCS, not as the only therapeutic option for tear replacement.. Stimulation of tear production can be achieved by the use of pilocarpine (oral or topical therapy) and topical cyclosporine A therapy. A dilute (1/4 %) pilocarpine solution can be used as a topical drop or oral 2 % pilocarpine can be added to the food (At 1 drop of a 2 % pilocarpine solution per 10 kg. body weight). Cyclosporine A (CSA) is the treatment of choice for KCS. One can use topical CSA every 12 hours as a 1-2 % solution (mixed in corn or mineral oil) or the commercially prepared 0.2 % ointment (Optimmune®). I find that the topical solution to be very effective, easier for clients to instill, and ...
To treat any underlying infection.. Artificial tears (Refresh®, Celluvisc®, Hylashield®) can be used to substitute tears, but literally must be instilled every 30-60 minutes if used as sole therapy for dry eyes. This not only is impractical, but also not necessary for our patients. Use artificial tears as adjunctive therapy for KCS, not as the only therapeutic option for tear replacement.. Stimulation of tear production can be achieved by the use of pilocarpine (oral or topical therapy) and topical cyclosporine A therapy. A dilute (1/4 %) pilocarpine solution can be used as a topical drop or oral 2 % pilocarpine can be added to the food (At 1 drop of a 2 % pilocarpine solution per 10 kg. body weight). Cyclosporine A (CSA) is the treatment of choice for KCS. One can use topical CSA every 12 hours as a 1-2 % solution (mixed in corn or mineral oil) or the commercially prepared 0.2 % ointment (Optimmune®). I find that the topical solution to be very effective, easier for clients to instill, and ...
Pilocarpine is a muscarinic receptor agonist. Pilocarpine is useful in treating patient with wide angle glaucoma and narrow angle glaucoma.
20 July 2018 (Circular No. SP PPUM: 283/2018):. Name of Medication: Pilocarpine 2% and 4%. Form: Eye Drop. Company: Alcon Laboratories (M) Sdn. Bhd.. Formulary Category: Standard. The sole distributor of Pilocarpine both 2% and 4% eye drops, Alcon Laboratories (M) Sdn. Bhd., had ceased their production and our pharmacy will supply our patients until all our current stocks have been used up.. However, doctors can consider to use other Standard Formulary eye drops such as Latanoprost and Timolol as an alternative for our patients. ...
Pilocarpine 1% and 2% is an ophthalmic solution used to treat glaucoma in dogs. Pilocarpine has the ability to relieve the pressure in your dogs eye by allowing fluid to drain more easily. It can be used before and after surgery.
Pilocarpine Hydrochlorid 1% Minimus is a medicine available in a number of countries worldwide. A list of US medications equivalent to Pilocarpine Hydrochlorid 1% Minimus is available on the Drugs.com website.
Experimental animals. Experiments in adult rats and P21 (with P1 defined as the day of birth) rats were carried out at the Mario Negri Institute. Adult (250-300 g) and P21 male Sprague-Dawley rats (Charles River Laboratories) were used. Male pups from 4 independent litters were used and were housed with their dams at constant temperature (23°C) and relative humidity (60%) with a fixed 12-hour light/12-hour dark cycle and free access to food and water until weaning at P21. Older animals were housed 1 per cage.. Pilocarpine-induced SE in P21 rats. Lithium chloride (3 meq/kg; Merck Sharp & Dohme) was injected i.p. in P20 rats, 18 hours before the s.c. injection of pilocarpine (60 mg/kg; Sigma-Aldrich) (36-38). Controls were age-matched rats injected with lithium chloride and with an equivalent volume of vehicle (PBS, pH 7.4) instead of pilocarpine. All animals received an injection of 10% sucrose in PBS 2 hours after the onset of SE to improve hydration. SE was not interrupted by any drug ...
Animals. Wistar rats (Simonsen Labs, Gilroy, CA) of either sex were used in this study. The Committees on Animal Research at the University of California, Los Angeles, and the Sepulveda Veterans Affairs Medical Center approved all protocols. Rat pups of 2, 3, and 4 weeks of age and mature rats (12-16 weeks of age) were given 3 mEq/kg lithium chloride (Sigma, St. Louis, MO) intraperitoneally on the day before the induction of SE. Seizures progressing to SE were induced by subcutaneous injection of 60 mg/kg pilocarpine hydrochloride (Sigma). Control animals were given an equal volume of saline subcutaneously. Rats were observed for behavioral evidence of seizures. Only rats displaying behavioral manifestations of seizures described previously (Jope et al., 1986; Hirsch et al., 1992) were used. The selected animals underwent blood gas monitoring 5 min before the administration of PC, and 2, 4, and 6 hr after. We have previously recorded electrographic seizures from both the hippocampus and parietal ...
Salagen (Pilocarpine) 5mg Tab 80p @chemistdirect.Must have a valid UK prescription to purchase.Treats symptoms of dry mouth & eyes asso with Sj grens syndrome
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SALAGEN (Pilocarpine) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
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Controlled Therapeutics (Cytokine PharmaSciences) and Marillion Pharmaceuticals are developing a controlled-release insert that delivers pilocarpine, PilobucTM,
This medicine is only for use in the eye. Do not take by mouth. Follow the directions on the prescription label. Wash hands before and after use. With your middle finger, apply pressure to the inside corner of your eye for 1 to 2 minutes. Tilt your head back slightly and pull your lower eyelid down with your index finger to form a pouch. Try not to touch the tip of the dropper to your eye, fingertips, or other surface. Squeeze the prescribed number of drops into the pouch. Do not blink for 30 seconds. Close your eye gently for 1 to 2 minutes to spread the drops.. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.. ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.. ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Learn about the potential side effects of Akarpine (pilocarpine). Includes common and rare side effects information for consumers and healthcare professionals.
Method of Reference Method of apoptotic Time after Comments Regions expressing apoptotic Fujikawa et al., 2000 TUNEL, EM, DNA 24 h, 72 h electrophoresis, H and E stain Kondratyev and Caspase-3 immuno., 24 h Gale, 2000 Hoechst and Texas Red DNA electrophoresis Pilocarpine Sankar et al., 1998 TUNEL, EM, DNA 24 h Fujikawa et al., 1999 TUNEL, EM, DNA 24 h, 72 h electrophoresis, H and E stain Roux et al., 1999 TUNEL and p75 1 day, 3 days necrotic cells can exhibit apoptotic markers necrotic cells.... ...
Article: Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats. ...
Looking for online definition of pilocarpine nitrate in the Medical Dictionary? pilocarpine nitrate explanation free. What is pilocarpine nitrate? Meaning of pilocarpine nitrate medical term. What does pilocarpine nitrate mean?
The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac2-26 in an experimental model of status epilepticus (SE) was evaluated. Male Wistar rats were divided into Naive, Sham, SE and SE+Ac2-26 groups, and SE was induced by intrahippocampal injection of pilocarpine. In Sham animals, saline was applied into the hippocampus, and Naive rats were only handled. Three doses of Ac2-26 (1 mg/kg) were administered intraperitoneally (i.p.) after 2, 8 and 14 h of SE induction. Finally, 24 h after the experiment-onset, rats were euthanized for analyses of neuronal lesion and inflammation. Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment
Purpose: : Many studies have used carbachol iontophoresis (CARB-ionto) or topical pilocarpine eye drops to pharmacologically stimulate accommodation in Rhesus monkeys. These methods hinder ocular measurements at the time of drug application, provide inconsistent results, and have a slow time-course. Here, the utility, safety, time-course, stability and repeatability of intravenous pilocarpine (iv-PILO) and CARB-ionto stimulated accommodation are compared. Methods: : Experiments were performed under anaesthesia on 5 previously iridectomized monkeys aged 10 to 16 years. In 3 monkeys, accommodation was stimulated with CARB-ionto in 5 successive experiments and refraction measured with a Hartinger coincidence refractometer. In separate experiments, accommodation was stimulated using a 5 mg/kg bolus of iv-PILO given over 30 seconds followed by a continuous infusion of 20 mg/kg/hr for 5.5 minutes in 3 successive experiments with the same monkeys as well as in single experiments with 2 additional ...
Pilocarpine: Find the most comprehensive real-world treatment information on Pilocarpine at PatientsLikeMe. 52 patients with fibromyalgia, multiple sclerosis, major depressive disorder, generalized anxiety disorder, diabetes type 2, post-traumatic stress disorder, systemic lupus erythematosus, bipolar disorder, Parkinsons disease, panic disorder, rheumatoid arthritis, high blood pressure (hypertension), myalgic encephalomyelitis/chronic fatigue syndrome, persistent depressive disorder (dysthymia), amyotrophic lateral sclerosis, epilepsy, migraine, hypothyroidism, osteoarthritis, traumatic brain injury, bipolar II disorder, attention deficit/hyperactivity disorder, asthma, social anxiety disorder, high cholesterol (hypercholesterolemia), irritable bowel syndrome, idiopathic pulmonary fibrosis, gastroesophageal reflux disease, bipolar I disorder or psoriasis currently take Pilocarpine.
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In the rodent model of temporal lobe epilepsy, there is extensive synaptic reorganization within the hippocampus following a single prolonged seizure event, after which animals eventually develop epilepsy. The perineuronal net (PN), a component of the neural extracellular matrix (ECM), primarily surrounds inhibitory interneurons and, under normal conditions, restricts synaptic reorganization. The objective of the current study was to explore the effects of status epilepticus (SE) on PNs in the adult hippocampus. The aggrecan component of the PN was studied, acutely (48 h post-SE), sub-acutely (1 week post-SE) and during the chronic period (2 months post-SE). Aggrecan expressing PNs decreased by 1 week, likely contributing to a permissive environment for neuronal reorganization, and remained attenuated at 2 months. The SE-exposed hippocampus showed many PNs with poor structural integrity, a condition rarely seen in controls. Additionally, the decrease in the aggrecan component of the PN was ...
Chemicals and Reagents.l-[N-methyl]-[3H]Scopolamine methyl chloride ([3H]NMS; specific activity, 80-90 Ci/mmol) and guanosine 5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS; specific activity, ,1000 Ci/mmol) and wheat germ agglutinin SPA beads were obtained from Amersham Biosciences (GE Healthcare, Chalfont St. Giles, Buckinghamshire, UK). The 96-deep-well plates and 500-cm2 cell culture plates were purchased from Thermo Fisher Scientific (Waltham, MA). The 96-well GF/B filter plates were purchased from Millipore (Watford, UK). HBSS, sodium bicarbonate, EDTA, sodium chloride, HEPES, dimethyl sulfoxide, BSA, GTP, GDP, saponin, probenecid, acetylcholine chloride, carbachol chloride, methacholine chloride, bethanechol chloride, oxotremorine-M, oxotremorine sesquifumarate, and pilocarpine hydrochloride were obtained from Sigma Chemical Co Ltd. (Poole, UK). Brilliant black was obtained from ICN Biomedicals Inc. (Solon, OH). Pluronic acid, Fluo-4-AM and all cell culture reagents were purchased from ...
ABSTRACT. The aim of this study is to present a Quick and Easy formula for the calculations of percent spike recovery of drug samples. Currently there are several cumbersome methods used in the determination of percent spike recovery in pharmaceutical analyses performed in various laboratories including the FDA laboratories around the world and especially in USA. In this paper we have compared the Quick & Easy Method using Pals formula against the method suggested by ORA Manual. The efficacy of this new formula has been demonstrated by seven examples including the main example of Pilocarpine hydrochloride discussed in detail. This Quick & Easy method is very simple, efficient and convenient way of determining percent spike recoveries and RPD values of duplicate spike solutions in drug analyses by HPLC, GC or UV methods. The simplicity of the method saves time and effort when compared to the existing method. Keywords: Pals formula, ORA Manual. ...
The skin of the rabbits ear is considerably more resistant than the abdominal skin to the phenomenon of local skin reactivity to bacterial filtrates. Ten times the provocative dose is required if it is given into the vein of the prepared ear and thirty times the provocative dose if it is given into the vein of the non-prepared ear.. The state of reactivity cannot be elicited by a preparatory intravenous injection of bacterial filtrates alone into clamped and non-clamped ears. The state also fails to appear in combination with cold, xylol, ethyl urethane, pilocarpine hydrochloride, atropine, calcium gluconate, guinea pig liver extract, histamine dihydrochloride, adrenalin chloride, and pituitrin.. Preparatory intravenous injections of toxins are capable of eliciting the state of reactivity in the rabbits ear when they are accompanied by thermal hyperemia (i.e., exposure to 45°, 50°, and 55°C.). It is also possible to induce the state of reactivity when a mixture of the preparatory factors ...
[...] involved the use of pilocarpine hydrochloride. El clorhidrato de fenazopiridina (Pyridium) es el ms comn de este tipo de frmacos. Phenazopyridine hydrochloride (Pyridium) is the most common of this type of drug. Este mismo usuario concluye que, con la imposicin de un derecho antidumping al nivel propuesto, exist
Objectives: To investigate the localization and progressive changes of cyclic-AMP dependent protein kinase (cPKA) in the mouse hippocampus at acute stages during and after pilocarpine induced status epilepticus. Methods: Pilocarpine induced status epilepticus mice were sacrificed 30 min, 2 h or 1 day after the start of a ∼7 h lasting status as assessed by video-electroencephalography. Brains were processed for quantitative immunohistochemistry of hippocampal cPKAβ and cPKAγ, and immunohistochemical co-localization of cPKAβ and cPKAγ with calbindin (CB), calretinin (CR), and parvalbumin (PV). Results: Based on anatomical and morphological assessment, cPKAβ was primarily expressed by principal cells and cPKAγ by interneurons. In CA1, cPKAβ co-localized with 76% of CB, 41% of CR, and 95% of PV-immunopositive cells, while cPKAγ co-localized with 50% of CB, 29% of CR, and 80% of PV-immunopositive cells. Upon induction of status epilepticus, cPKAβ expression was transiently reduced in CA1, ...
Synonyms for status epilepticus in Free Thesaurus. Antonyms for status epilepticus. 1 word related to status epilepticus: epilepsy. What are synonyms for status epilepticus?
OBJECTIVES: Therapeutic coma is advocated in guidelines for management of refractory status epilepticus; this is, however, based on weak evidence. We here address the specific impact of therapeutic coma on status epilepticus outcome.. DESIGN: Retrospective assessment of a prospectively collected cohort.. SETTING: Academic hospital.. PATIENTS: Consecutive adults with incident status epilepticus lasting greater than or equal to 30 minutes, admitted between 2006 and 2013.. MEASUREMENTS AND MAIN RESULTS: We recorded prospectively demographics, clinical status epilepticus features, treatment, and outcome at discharge and retrospectively medical comorbidities, hospital stay, and infectious complications. Associations between potential predictors and clinical outcome were analyzed using multinomial logistic regressions. Of 467 patients with incident status epilepticus, 238 returned to baseline (51.1%), 162 had new disability (34.6%), and 67 died (14.3%); 50 subjects (10.7%) were managed with ...
Pilocarpine (C11H16N202 = 206.63) is an alkaloid derived from the leaves of Pilocarpus jaborandi, a shrub of eastern Brazil. Pharmacodynamics. Central Nervous System is depressed in the lower ce...
TY - JOUR. T1 - Vitreous hemorrhage associated with pilocarpine. AU - Schuman, Joel S.. AU - Hersh, Peter. AU - Kylstra, Jan. PY - 1989/9/15. Y1 - 1989/9/15. UR - http://www.scopus.com/inward/record.url?scp=0024434429&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0024434429&partnerID=8YFLogxK. U2 - 10.1016/0002-9394(89)90132-3. DO - 10.1016/0002-9394(89)90132-3. M3 - Letter. C2 - 2774045. AN - SCOPUS:0024434429. VL - 108. SP - 333. EP - 334. JO - American Journal of Ophthalmology. JF - American Journal of Ophthalmology. SN - 0002-9394. IS - 3. ER - ...
Delayed first-line benzodiazepine treatment is independently associated with major adverse outcomes in children with status epilepticus (SE), according to a JAMA Neurology study. The results raise the question as to whether poor outcomes could, in part, be prevented by earlier administration of treatment.. Patients in the status epilepticus study were admitted with refractory convulsive SE to 11 pediatric tertiary hospitals in the United States and stratified into two groups - those who received timely first-line benzodiazepine (i.e., given within less than 10 minutes of seizure onset); and those who received treatment within 10 or more minutes.. The status epilepticus study associated an untimely treatment with a higher frequency of death, use of continuous infusions, longer convulsion duration, and more frequent hypotension. These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is ...
Status epilepticus refractory to first-line and second-line antiepileptic treatments challenges neurologists and intensivists as mortality increases with treatment refractoriness and seizure duration. International guidelines advocate anesthetic drugs, such as continuously administered high-dose midazolam, propofol, and barbiturates, for the induction of therapeutic coma in patients with treatment-refractory status epilepticus. The seizure-suppressing effect of anesthetic drugs is believed to be so strong that some experts recommend using them after benzodiazepines have failed. Although the rationale for the use of anesthetic drugs in patients with treatment-refractory status epilepticus seems clear, the recommendation of their use in treating status epilepticus is based on expert opinions rather than on strong evidence. Randomized trials in this context are lacking, and recent studies provide disturbing results, as the administration of anesthetics was associated with poor outcome independent ...
SS is a systemic autoimmune exocrinopathy characterised by dysfunction of the lachrymal and salivary glands. This decrease in secretory function leads to the symptoms of dry eyes and dry mouth and the objective findings of KCS and xerostomia. Recent studies support the hypothesis that interaction between immune factors and the neuroendocrine system may affect the tear producing mechanism of the exocrine glands. Proinflammatory cytokines may be responsible for damaging secretory glands and the presence of autoantibodies may influence the response of the muscarinic M3 receptors.9,10 Thus, the ability to modulate the immune response and stimulate residual glandular elements provides a new therapeutic opportunity for patients with SS. Systemic corticosteroid treatment may increase salivary and tear secretion, but it is associated with significant long term side effects that outweigh its benefit for this purpose.4 Systemic agents, including antimalarial drugs,11 cyclosporin A,12 methotrexate,13 and ...
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TY - JOUR. T1 - Baseline and outcome assessment in pediatric status epilepticus. AU - Jafarpour, Saba. AU - Stredny, Coral M.. AU - Piantino, Juan. AU - Chapman, Kevin E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Purpose: To summarize different aspects of short and long-term outcomes associated with SE, including mortality, recurrence, subsequent epilepsy, neurocognitive dysfunction, imaging abnormalities, and health-related quality of life. Methods: We searched MEDLINE for studies that assessed the short-term and long-term outcome of status epilepticus in pediatric population, including mortality, recurrence of seizure and status epilepticus, neurological, cognitive, or behavioral impairment, and health-related quality of life. We excluded studies that exclusively assessed the adult population. Results: Mortality in pediatric SE is relatively low, while morbidity poses more challenges. The underlying cause of SE has been shown to be a major determinant in the outcome after SE. However, it is ...
Albino mice weighing approximately 60±0.5 gm were taken as experimental and control animals. Both the control and experimental mice were injected intraperitonally with atropine to reduce peripheral activity. Pilocarpine was dosed along with phosphate buffer against the muscarinic and glutamate receptors to the experimental mice to induce seizures in the mice. Seventeen days after the injection, the experimental and control mice were sacrificed. The brain parts and other body parts were dissected. The muscle of the experimental and control mice were taken for the experiment. Acetyl choline esterase (AchE) assay was done in muscle tissue of epileptic mice by spectrophotometric method. The kinetic parameter Vmax, the maximum rate of reaction and Km, Michaelis menten constant of acetyl choline esterase enzyme were studied in the membrane fraction of muscle tissue in epileptic condition. The result shows increase in the Vmax during epileptic condition than that of the control. Michaelis Menten ...
A seizure that lasts at least 30 minutes is called status epilepticus, or a prolonged seizure. This is a medical emergency that may lead to permanent brain damage or death. Many medical experts become concerned that a seizure is status epilepticus after it lasts 5 to 10 minutes.
A seizure that lasts at least 30 minutes is called status epilepticus, or a prolonged seizure. This is a medical emergency that may lead to permanent brain damage or death. Many medical experts become concerned that a seizure is status epilepticus after it lasts 5 to 10 minutes.
A seizure that lasts at least 30 minutes is called status epilepticus, or a prolonged seizure. This is a medical emergency that may lead to permanent brain damage or death. Many medical experts become concerned that a seizure is status epilepticus after it lasts 5 to 10 minutes.
Objective: The prognosis of status epilepticus (SE) is highly related to the underlying etiology. Inflammation of the central nervous system (CNS), including infection and autoimmune encephalitis, is one of the treatable conditions causing SE. The initial presentation of infectious and autoimmune CNS disorders can be quite similar, which may be difficult to differentiate at the beginning. However, treatment for these entities can be quite different. In this study, we aim to identify the differences in clinical features among patients with infectious and autoimmune SE, which could help the clinicians to select initial investigation and ensuing therapies that may improve overall outcomes.Methods: This was a retrospective study that included 501 patients with SE within a period of 10.5-years. Patients with inflammatory etiology were collected and separated into infectious and autoimmune SE. The symptoms at onset, SE semiology, status epilepticus severity score, and END-IT score at admission, treatment for
The most common medical neurologic emergency in childhood, status epilepticus (SE) is a serious and often life-threatening medical emergency.The definition, pathophysiology, classification, risk factors, and outcome of status epilepticus in children
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Status epilepticus (SE) is the most common neurologic emergency, with rates estimated between 1.3 and 81 cases per 100,000 people per year.
Status Epilepticus. In: Hay, Jr WW, Levin MJ, Deterding RR, Abzug MJ. Hay, Jr W.W., Levin M.J., Deterding R.R., Abzug M.J. Eds. William W. Hay, Jr, et al.eds. Quick Medical Diagnosis & Treatment Pediatrics New York, NY: McGraw-Hill; . http://accesspediatrics.mhmedical.com/content.aspx?bookid=2196§ionid=167755738. Accessed December 12, 2017 ...
When you experience status epilepticus, theres no retreating to the excuse Its all Greek to me. But hope might be on the horizon!
TY - CHAP. T1 - Status epilepticus. AU - Wray, Carter. AU - Knupp, Kelly. PY - 2011/12/1. Y1 - 2011/12/1. UR - http://www.scopus.com/inward/record.url?scp=84882481237&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84882481237&partnerID=8YFLogxK. U2 - 10.1016/B978-0-323-05405-8.00090-5. DO - 10.1016/B978-0-323-05405-8.00090-5. M3 - Chapter. AN - SCOPUS:84882481237. SN - 9780323054058. SP - 370. EP - 373. BT - Bermans Pediatric Decision Making. PB - Elsevier Inc.. ER - ...
Xerostomia is a subjective sensation of dry mouth, this is a common symptom particularly in older adults and has a variety of causes. Pilocarpine is a cholinergic agonist that non-selectively binds to muscarinic receptors in smooth muscles in the gastrointestinal, urinary and pulmonary systems and stimulates the production of secretions from the salivary and sweat [read the full story…]. ...
Aster tataricus attenuates the neuronal cell damage and restores the cognitive functions in epileptic rat, Bei-lei Hu, Wei-chen Hou, Xiao-ping Li, Lian-jun Ma, Xiao-xue Bai, Qun Li
Kasus yang akan kami bagikan ini adalah kasus kehamilan ganda terbaru dari program IVF di Gladiool. Jumlah keberhasilan dengan kehamilan ganda (kembar/twin) di klinik kami hanya 10% dari seluruh keberhasilan (sebagian besar tunggal). Hal ini dikarenakan sebagian besar pasien menggunakan siklus natural atau mild stimulation sehingga sebagian besar kami melakukan transfer 1 (single) embryo. …
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