We show that the observed ferromagnetic behavior of ZnO lightly doped with Mn coincides with the presence of MnO nanoparticles, whereas cluster-free Mn doped ZnO behaves paramagnetically. This conclusion is reached by a study of the structural and magnetic properties of powdered samples of (Mn-x, Zn1-x) O with x ,= 0.033 using polarized neutron scattering. Two types of samples were synthesized via, respectively, a solid state method and the decomposition of hydrozincite. Further characterization has been performed using standard X-ray diffraction and magnetization measurements. The results show evidence for the formation of MnO nanoparticles in the highest doped samples for both synthesis methods, with a ferromagnetic behavior attributed to uncompensated Mn2+ in the MnO nanoparticles. The lower Mn-doped samples showed no evidence for structural segregation or magnetic correlations and showed only a paramagnetic behaviour. Published by AIP Publishing.. ...
Trait-based approaches have led to significant advances in plant ecology, but are currently biased toward above-ground traits. It is becoming clear that a stronger emphasis on below-ground traits is needed to better predict future changes in plant biodiversity and their consequences for ecosystem functioning. Here I propose six below-ground frontiers in trait-based plant ecology, with an emphasis on traits governing soil nutrient acquisition : redefining fine roots ; quantifying root trait dimensionality ; integrating mycorrhizas ; broadening the suite of root traits ; determining linkages between root traits and abiotic and biotic factors ; and understanding ecosystem-level consequences of root traits. Focusing research efforts along these frontiers should help to fulfil the promise of trait-based ecology : enhanced predictive capacity across ecological scales.. View online ...
We are conducting a study called "Smart searching for the Physiome Project" aiming to add to the Physiome Model Repository (PMR) a "Google search" style interface for information, models, and knowledge retrieval. The interface will be simple yet powerful, so it will be useful and can be easily used by advanced and less experienced users alike.. Therefore, we need your participation by answering questions along with your activity in the PMR which are intended to gather data regarding the PMR on your:. ...
Email: [email protected] Phone: (206) 685-2012. Dr. Bassingthwaightes lab uses multiple radioactive tracers simultaneously to measure reactions of adenosine and its metabolites and to determine their rates of transport across membranes. Models describe the kinetics in a precise way, allowing us to understand the regulation. He is also the originator of the Human Physiome Project, a large-scale international program for developing databasing and biological systems modeling for understanding genomic and pharmaceutic effects on human physiology. His program is highly collaborative, involving co-investigators at a dozen U.S. universities, several in Europe, and in 14 departments at the University of Washington. Some of these are involved in the Physiome Project, in particular the Cardiome Project. The Cardiome Project, to define a functional heart in mathematical terms, extends from the biochemistry and the signaling, to the mechanics and energetics of the three-dimensional heart.. View Bio. ...
Fungi play many essential roles in ecosystems. They facilitate plant access to nutrients and water, serve as decay agents that cycle carbon and nutrients through the soil, water and atmosphere, and are major regulators of macro-organismal populations. Although technological advances are improving the detection and identification of fungi, there still exist key gaps in our ecological knowledge of this kingdom, especially related to function. Trait-based approaches have been instrumental in strengthening our understanding of plant functional ecology and, as such, provide excellent models for deepening our understanding of fungal functional ecology in ways that complement insights gained from traditional and -omics-based techniques. In this review, we synthesize current knowledge of fungal functional ecology, taxonomy and systematics and introduce a novel database of fungal functional traits (FunFun ). FunFun is built to interface with other databases to explore and predict how fungal functional ...
Discovery challenges previous models for environment in which early life evolved. Over the last half-billion years, the ocean mostly has been full of oxygen and teeming with animal life. But earlier, before animals evolved, oxygen was harder to come by.. Now a new study, led by researchers at the University of California, Riverside (UCR), reveals that the ancient deep ocean was not only devoid of oxygen but also rich in iron, a key biological nutrient for nearly a billion years longer than previously thought--right through a key evolutionary interval that culminated in the first rise of animals.. "The implications are far-reaching," said Timothy Lyons, a biogeochemist at UCR and the principal investigator of the study, which was funded by the National Science Foundation (NSF).. "We will need to rethink, in a fundamental way," says Lyons, "all our models for how life-essential nutrients were distributed in the ocean through time and space.". The results appear in this weeks issue of the journal ...
This chapter explores the intersection of stress biology, community ecology, and meta-level molecular sciences. The understanding of bacterial life is more sophisticated than that of any other group of organisms, despite the tremendous physiological complexity that is the hallmark of the prokaryotes. Much of microbial cell and molecular biology is based on the assumption that the behaviors of individuals and populations of cells are the same and this is often the case. Communities can be thought of as collections of organisms, each conducting a living in the context of the rest of the community. Metagenomics provides a system-level approach to studying communities of microorganisms. In studies of gene discovery based on functional expression, metagenomics can facilitate analysis of genes in both the culturable and unculturable portions of the community. The gut microbial community is emerging as one of the most influential organs in the human body. The fusion of reductionism and systems biology can be
As a laryngologist and phoniatrician, Dr. Murano has diagnosed and treated patients with transitory and progressive neurologic dysfunctions. To answer questions about how humans adapt and learn new strategies for breathing, swallowing, and speaking to compensate for even slight changes in function caused by disease, medical interventions, or simple aging, Dr. Murano has used dynamic MRI techniques to view the digestive airways functions and the complex muscle interdigitation in tongue, lips, pharynx, and soft palate. The physiological complexity of the control of the orchestrate muscles of the digestive airways has led her to incorporate electromyography and tagged-MRI in her research and thereby quantify speech and swallowing movement and internal tissue deformation. Specifically, her expertise in fine hooked wire electromyography of the head and neck muscles for voicing, speech, and mastication enables her to tailor functional questions of motor control in speech and swallowing that are not ...
Context • The benefits of a mindfulness meditation (MM) intervention are most often evidenced by improvements in self-rated stress and mental health. Given the physiological complexity of the psychological stress system, it is likely that some people benefit significantly, whereas others do not. Clinicians and researchers could benefit from further exploration to determine which baseline factors can predict clinically significant improvements from MM. Objectives • The study intended to determine (1) whether the baseline measures for participants who significantly benefitted from MM training were different from the baseline measures of participants who did not, and (2) whether a classification analysis using a decision-tree, machine-learning approach could be useful in predicting which individuals would be most likely to improve ...
Context • The benefits of a mindfulness meditation (MM) intervention are most often evidenced by improvements in self-rated stress and mental health. Given the physiological complexity of the psychological stress system, it is likely that some people benefit significantly, whereas others do not. Clinicians and researchers could benefit from further exploration to determine which baseline factors can predict clinically significant improvements from MM. Objectives • The study intended to determine (1) whether the baseline measures for participants who significantly benefitted from MM training were different from the baseline measures of participants who did not, and (2) whether a classification analysis using a decision-tree, machine-learning approach could be useful in predicting which individuals would be most likely to improve ...
Reactome:REACT_100463, Reactome:REACT_104378, Reactome:REACT_106986, Reactome:REACT_107353, Reactome:REACT_107808, Reactome:REACT_110691, Reactome:REACT_34638, Reactome:REACT_6946, Reactome:REACT_77304, Reactome:REACT_78116, Reactome:REACT_87183, Reactome:REACT_88148, Reactome:REACT_90436, Reactome:REACT_92149, Reactome:REACT_92596, Reactome:REACT_93357, Reactome:REACT_95391, Reactome:REACT_98332, Reactome:REACT_99471, Reactome:REACT_99529, Wikipedia:Methylation ...
The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of
Exercise has many benefits in preventing illnesses and injuries. But what about those people who have a modified physiological system (MPS) because they have experienced an accident or illness? Or because they are pregnant? How does exercise affect those individuals? Does exercise still help those people?. The Exercise-Reports.com Special Populations section is dedicated to documenting the risks and benefits of exercise regarding modified physical conditions caused by pregnancy, accidents, and illnesses.. Please check the folder categories at left for information on specific special population categories.. Remember that any information that is reported, should not replace the advice of your physician.. ...
To quickly and easily query samples, annotation categories adopt a flat list instead of a tree structure. For example, only two annotations, the Organism Part and the Organism Part Subtype, are used to describe the sample location in anatomic position. This choice is motivated by the increased complexity of the ontological tree structure in our web design. Additionally, the Organism Part is only used to describe the sample location in MGED ontology. In M2DB, we created the Organism Part Subtype to assist users to define the sample location. For example, T lymphocyte samples can be derived from blood, bone marrow, or umbilical cord blood in the database. The two annotations, Organism Part and Organism Part Subtype, can be more accurate, efficient, and less complicated to define the sample location. According to our annotation categories, users can easily and quickly find samples defined in the selection via our web query interface. It provides instantaneous visualization and selective combination ...
ABSTRACT: A modified version of a previously developed mathematical model [Obeyesekere et al., Cell Prolif. (1997)] of the G1-phase of the cell cycle is presented. This model describes the regulation of the G1-phase that includes the interactions of the nuclear proteins, RB, cyclin E, cyclin D, cdk2, cdk4 and E2F. The effects of the growth factors on cyclin D synthesis under saturated or unsaturated growth factor conditions are investigated based on this model. The solutions to this model (a system of nonlinear ordinary differential equations) are discussed with respect to existing experiments. Predictions based on mathematical analysis of this model are presented. In particular, results are presented on the existence of two stablesolutions, i.e., bistability within the G1-phase. It is shown that this bistability exists under unsaturated growth factor concentration levels. This phenomenon is very noticeable if the efficiency of the signal transduction, initiated by the growth factors leading to ...
Computational modelling in molecular cardiology has recently focused on simulating subsets of myocardial excitation-contraction processes. As people try to improve their understanding of myocardial function, there is an increasing interest in excitation-contraction coupling and mechanical events in cardiac muscle. It is hoped that these computer simulations will also help explain the pathophysiological mechanisms of heart failure. In their 2001 paper, Mlcek, Neumann, Kittnar and Novak concentrate on the molecular level of electromechanical events in cardiac muscle. They introduce an actomyosin subsystem accompanied by a simple regulatory subsystem involving calcium binding to troponin C (see the figure below). They performed many simulations to prove the stability of their model and they then used the simulation results to help interpret experimental and clinical data. The complete original paper reference is cited below: Mathematical Model of the Electromechanical Heart Contractile System - ...
ABSTRACT: In this paper, we propose and analyse a mathematical model for chronic myelogenous leukemia (CML), a cancer of the blood. We model the interaction between naive T cells, effector T cells, and CML cancer cells in the body, using a system of ordinary differential equations which gives rates of change of the three cell populations. One of the difficulties in modeling CML is the scarcity of experimental data which can be used to estimate parameters values. To compensate for the resulting uncertainties, we use Latin hypercube sampling (LHS) on large ranges of possible parameter values in our analysis. A major goal of this work is the determination of parameters which play a critical role in remission or clearance of the cancer in the model. Our analysis examines 12 parameters, and identifies two of these, the growth and death rates of CML, as critical to the outcome of the system. Our results indicate that the most promising research avenues for treatments of CML should be those that affect ...
The Systems/Parts category is designed to help understand the characteristics of specific physiological systems or body parts. The relationship of each system or body part is described in its association with exercise, fitness, structure, function, risks, use for safety and use for performance. By understanding the systems and body parts you will have a better understanding of how to improve performance and longevity and avoid injuries.. Each physiological system or body part is listed with its characteristics of function, importance in development and maintenance, strengths, weaknesses, adaptive responsive to exercise, and vulnerability to risks and associated precautions.. Understanding exercise and its effect on physiology is key to understanding the science of human performance and improving human performance. Exercise Physiology is the main academic category that covers the logical explanations of physiological systems under stress of activity. Other studies include Anatomy, Ergonomics, ...
Reactome is an open-source, open access, manually curated and peer-reviewed pathway database. Pathway annotations are authored by expert biologists, in collaboration with Reactome editorial staff. The rationale behind Reactome is to convey the rich information in the visual representations of biological pathways familiar from textbooks and articles in a detailed, computationally accessible format. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes and small molecules) participating in reactions form causal chain of events or pathways.. Learn more about the Reactome Website and Pathway Analysis tools ...
High Altitude Pseudo Satellites (HAPS) operating for extended periods at an altitude of approximately 20 km complement and extend the capabilities of satellites in the domains of Earth Observation, Telecommunication and Navigation. HAPS, in synergy with satellites, offer unique capabilities for the development of value adding applications and science. With over 200 participants, the HAPS4ESA 2017 workshop was the first meeting in Europe bringing together HAPS system, payload and applications developers, institutional stakeholders, space agencies and scientists.. Building on this success, the European Space Agency is again reaching out to the Earth Observation, Telecommunication and Navigation communities to review the State-of-the-Art and the future perspectives of HAPS in a changing Space 4.0 environment and with a specific focus regarding potential ESA HAPS activities to be decided at the next ESA Council at Ministerial level in 2019 (Space19+). The event will take place from 12 to 14 February ...
RNA Biology. Post-transcriptional processes play a crucial role in controlling gene expression in all organisms. Our research is aimed at elucidating the mechanisms by which such control is imposed. To identify and characterize the proteins, RNA elements, and molecular mechanisms that govern these key regulatory processes, we employ a comprehensive approach combining biochemical, molecular biological, and genetic methods. We are particularly interested in understanding how gene expression in bacterial and mammalian cells is regulated by mRNA degradation.. Detailed Research Summary ...
Our methods of integrating different structural biology approaches and putting molecular complexes into a cellular context can certainly be applied to almost any field, including the field of infection biology. On the systems level, interesting research is also conducted. For example, Jörg Vogel, the director of the Institute for Molecular Infection Biology at University of Würzburg, who will also be talking at the symposium, is investigating the cellular response to bacterial infection and determining how gene expression is changed upon infection. I am looking forward to hearing him speak and to learning more about the different areas in infection biology that require structural biology approaches ...
A new interdisciplinary Northwestern University study reports that the important protein-DNA bond can be broken by unbound proteins floating around in the cell. This discovery sheds light on how molecules self-organize and how gene expression is dynamically controlled. The way proteins interact with DNA determines the biological activity of all living organisms, said John F.…
My research is focused on how the control of neural-behaviour is organized. I am particularly interested in how gene expression in neurons has an impact on the function of neural circuits. We use this line of questioning to explore how epilepsy and major depressive disorder may arise from the inappropriate control of genetic information.
Taken together, our mRNA and protein analyses of lymphoblastoid cells undergoing apoptosis indicate that both mitochondria- and receptor-mediated pathways of apoptosis are activated by exposure to NO· and modulated by p53. We attribute the differences in responses of TK6 and WTK-1 cells to NO· treatment to their differing p53 status, because these cell lines were derived from the same donor source and thus are closely related. However, because both cell lines have been in culture for many years, contributions by factors other than p53 status cannot be completely ruled out. Several features of the data support our interpretation. p53 protein was activated and accumulated in TK6 cells upon exposure to NO· with kinetics consistent with the induction of p53-mediated transcription observed through microarray and reverse transcription-PCR analyses, which was abrogated in p53-mutant WTK1 cells. Furthermore, the transcriptional profile was driven by wild-type p53 at the time of maximum accumulation ...
Problem Stress influences an organisms physiological systems via an inverted u-shaped curve: An optimum amount of stress will optimize body functions, but too little stress or too much stress for long periods of time can impair body functions. Researchers have been very interested in exploring the mechanisms that may
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Looking for online definition of physiome in the Medical Dictionary? physiome explanation free. What is physiome? Meaning of physiome medical term. What does physiome mean?
To evaluate the effects of Tai Chi-a mind-body exercise--on age-related loss of physiological complexity (using fractal and entropy based measures), and to understand the relationship between complexity, function and adaptability, we will conduct a two-arm prospective randomized clinical trial. Our overarching goal is to evaluate if six months of Tai Chi training, compared to a waitlist control receiving standard medical care, can enhance physiological complexity and adaptability in older Tai Chi-naïve adults. Secondary goals of the study are to characterize the relationship between complexity biomarkers, measures of function, and resilience. This pilot study will inform a future more definitive trial by providing information on recruitment and retention, compliance, dose-dependent effects, preliminary estimates of effect size, and the optimal biomarkers of complexity, function, and adaptive capacity ...
What We Do: The Chemistry and Physiological Systems Research Branch (CPSRB) supports research on all aspects of chemistry and the physiological systems affected by drugs of abuse. Program Areas: This branch supports research programs on The effects of drugs on central nervous system and physiological systems, including those related to immune functions and AIDS The discovery of endogenous ligands, and the role of endogenous ligands and systems relevant to drug action, and addiction The studies of absorption, metabolism, pharmacokinetics, pharmacodynamics, elimination, transport and delivery Investigations on analytical methods development, proteomics, protein folding and related functional genomics and structural biology Synthesis, structure-function relationships, conformational studies, structural biology, ligand design of all drugs abuse; synthesis of affinity reagents, chemical probes, drug-receptor interaction model to elucidate drug action Perinatal drug
Longevity Personal Training and Exercise Physiology is proud to offer a full-time Exercise Physiologist role in our team. Longevity offered our first Exercise Physiology Services in mid-2016 and since then the popularity of the service has grown, making the role in a critical part of the Longevity services. This exciting opportunity comes with a hint of sadness however, as we say goodbye to our current Exercise Physiologist, Laura Long.. Laura has been a tremendous contributor to the Longevity team and has helped to grow our Exercise Physiology services to where they are today. We wish Laura all the best in her future career and studies and have no doubt she will find success in whatever she puts her mind to. As you can see from the following video, Laura was not just a great Exercise Physiologist but also impressed the whole team when we recently did our 1Rm testing on the deadlift movement:. ,iframe width="560″ height="315″ src="https://www.youtube.com/embed/AUMm9wfXL4E" frameborder="0″ ...
The following OM treatments have similar therapeutic mechanisms: Both quick stretch (rapid passive ROM) and tapping stimulate the muscle spindle to elicit a stretch reflex and thus increase muscle tone. Vibration also stimulates the muscle spindle; however, the resulting contraction of the stimulated muscle is the tonic vibratory reflex. As discussed earlier, only the jaw-closing muscles demonstrate muscle spindle actions similar to those of the limb musculature. Therefore, we would not expect these treatments to increase muscle tone of the labial, lingual, velar, or other speech muscles. Moreover, most physical rehabilitation texts caution against applying vibration to the face because of the risk of skin breakdown. Given the lack of physiologic rationale for using these tone-altering OM treatments, it is not surprising that virtually no studies have examined their potential application to the management of speech/swallowing disorders and thus no evidence is available to support their use ...
Working under the supervision of the Field Operations Manager, this position is responsible for administering and monitoring 12-Lead Cardiopulmonary diagnostic stress tests and Pulmonary Function exams in a field setting following Frontera protocols. Exercise Physiologists (EP) are required to and must have the capability to transport and move equipment into and out of physicians offices daily. Additionally, EPs in this position are required to assist with maintaining client accounts by means of educating physicians on clinical diagnoses and purposes for testing and have a general understanding of billing/insurance. The candidate must also be able to demonstrate exceptional interpersonal skills and have the ability to interact and adapt with professionalism to different circumstances and people. ...
Working under the supervision of the Field Operations Manager, this position is responsible for administering and monitoring 12-Lead Cardiopulmonary diagnostic stress tests and Pulmonary Function exams in a field setting following Frontera protocols. Exercise Physiologists (EP) are required to and must have the capability to transport and move equipment into and out of physicians offices daily. Additionally, EPs in this position are required to assist with maintaining client accounts by means of educating physicians on clinical diagnoses and purposes for testing and have a general understanding of billing/insurance. The candidate must also be able to demonstrate exceptional interpersonal skills and have the ability to interact and adapt with professionalism to different circumstances and people. ...
John Scott Haldane (1860-1936), British physiologist. Born and educated in Edinburgh, Haldane worked at Glasgow, Oxford and Birmingham universities. He was elected Fellow of the Royal Society (1897). In 1921, he became director of the Mining Research Laboratory. He recommended the use of mice in coal mines that would alert miners to the dangers of carbon monoxide poisoning. His research included the Haldane effect relating to haemoglobin and blood gases. He was made Companion of Honour in 1928 and awarded the Copley Medal (1934). Photographed in 1920 at Haldanes office at his residence on Linton Road, Oxford, UK. - Stock Image C022/5060
Recently, two exercise physiologists, Wendy Repovich and Janet Peterson, presented at the ACSM fitness summit and debunked some nutritional myths. Some were utter nonsense. Read below to see what I am talking about!
ESAs SMOS satellite has clocked up more than one billion kilometres orbiting Earth to improve our understanding of our planets water cycle. Marking its fifth birthday, all the data collected over land and ocean have been drawn together to show how moisture in the soil and salinity in the ocean change over the year.. ...
目的】 通过研究高龄老人的医疗情况,躯体功能和营养状态,提高对高龄老人健康维护相关因素的理解。. 【方法】 ELSA 85 项目(林雪平老年人普查,Elderly in Linköping Screening Assessment)是一个以瑞典林雪平城市中85岁高龄老人(1922年出生, n = 650)为研究对象的人群研究。(1) 2007/03-2008/03:通过邮寄问卷,家庭访问及门诊检查的三个步骤, 我们搜集的数据包括:个人和家庭的背景信息(居住情况,既往的学历和工作程度,健康相关的生活质量EQ-5D等),身体机能(日常生活活动能力ADL评定,移动性测试等)和营养状态(人体测量等)。我们同时还阅览了所有注册的电子病历和每位老年人的年卫生费用。(2) 2010/06-2010/10: 在3年后的随访中,我们对所有88岁的女性老年人增加了人体组成测定和SF-36健康调查量表之生理功能子量表(SF-36PF)的评估。. ELSA 85 ...
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Please feel free to forward this e-mail. Thank you, ************************ First Virtual Conference in Genomics and Bioinformatics October 15 & 16, 2001 At World-Wide Access Grid Locations Sequencing projects and genomics research has led to an explosive rate of data accumulation and to a shift in the way biological research is conducted. Bioinformatic tools of the post-genome era are providing new insights about gene expression patterns, intron/exon structure, post-translational changes and protein interactions as well as phylogenetic relationships. Parallel analysis of thousands of genes using microarray technology has become a multi-disciplinary endeavor in which unsupervised and supervised learning is applied for gene expression clustering and/or classification. Although genomic technologies offer an enormous scientific potential to understand organisms at the molecular level, new challenges on the horizon are envisioned. There is a need for improvement of microarray technology, data ...
Embryonic organizing centers secrete signaling molecules that instruct target cells about their position and future identity. Information about cell position in relation to sources of instructive signals and about precursor cell lineages is key to our understanding of developmental processes that restrict cell potency and determine cell fate. We review adenohypophysis, lens, and olfactory placode formation and how gene expression patterns, cell positions, and cell fates in the anterior neural plate and anterior placodal field correlate in zebrafish and other vertebrates. Single cell lineage analysis in zebrafish suggests that the majority of preplacodal cells might be specified for pituitary, lens, or olfactory placode by the end of gastrulation ...
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Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.. ...
Model development and archiving support at physiome.org provided by the following grants: NIH U01HL122199 Analyzing the Cardiac Power Grid, 09/15/2015 - 05/31/2020, NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.. ...
One ofthe most puzzling phenomena in modern physiology is the existence of fractal patterns in a wide range of physiological systems (i.e., the structure of flu...
0 and z ranging from 0. в Model biochemical reactions, enzyme kinetics, diffusion, carrier-mediated transport and cna transport in a physiological system. 2. The primary role of the cymbal ta engineer in departmental management is providing documentation for regulatory agencies and supervision of personnel.
Linda S. Pescatello, Effects of Exercise on Hypertension: From Cells to Physiological Systems 2015 | ISBN-10: 3319170759 | 354 pages | PDF | 5 MB https://nit
Age is no excuse to stop improving our physical health with appropriate exercise and no one is too old to start, according to University of Greenwich sports physiologist Dr Bettina Karsten.. Date of release: Monday, October 31, 2016 ...
By now, most aerobic-dance enthusiasts realize Jane Fonda`s once-famous battle cry ``Go for the burn`` has gone up in smoke.Exercise physiologists tell us that burning your muscles -- working to the
Comparing unfished and fished communities with the three model versions: (a) community, (b) trait-based and (c) multispecies based on the North Sea. Top row: bi
Get information, facts, and pictures about Physiologist at Encyclopedia.com. Make research projects and school reports about Physiologist easy with credible articles from our FREE, online encyclopedia and dictionary.
5 randomized controlled trials (RCTs) of rehabilitative approaches for CFS in secondary care have been previously published. The first trial by Lloyd and colleagues (1) found that brief CBT was no better than medical care. Subsequent trials using more intensive treatment found substantial benefits over both usual care and relaxation therapy (2, 3). 2 RCTs of supervised, simple, graded exercise therapy (GET)-both of which showed some, although less, benefit-have also been published (4, 5). These trials were all of intensive therapy given by skilled practitioners in special centers. If therapy was better targeted, could less intensive treatment work? Could less skilled therapists deliver effective treatment? Are patient self-help groups as effective as these treatments? Powell and colleagues addressed the value of better targeted, but briefer, treatment. Although called "educational," the treatment was similar to CBT and GET but emphasized providing a physiologic rationale for rehabilitation. The ...
The effective detection and management of muscle-invasive bladder Transition Cell Carcinoma (TCC) continues to be an urgent clinical challenge. While some differences of gene expression and function in papillary (Ta), superficial (T1) and muscle-invasive (≥T2) bladder cancers have been investigated, the understanding of mechanisms involved in the progression of bladder tumors remains incomplete. Statistical methods of pathway-enrichment, cluster analysis and text-mining can extract and help interpret functional information about gene expression patterns in large sets of genomic data. The public availability of patient-derived expression microarray data allows open access and analysis of large amounts of clinical data. Using these resources, we investigated gene expression differences associated with tumor progression and muscle-invasive TCC. Gene expression was calculated relative to Ta tumors to assess progression-associated differences, revealing a network of genes related to Ras/MAPK ...
The physiologist Yannis Pitsiladis wants to redefine the limits of human endurance by training a man to run a marathon in less than 2 hours. A 1:59:59 marathon would require a searing pace of 4 minutes 34 seconds per mile, 7 seconds faster than the pace of the current world record. "I want to beat those on drugs," Yannis said, adding: "I want to say, in a sense, yes, drugs have been taken, but not by my athletes, and Ive just smashed the 2-hour barrier without them." The photographer @urielsinai took this photo of Yannis carrying the tools he needs to conduct a VO2max test - a measure of your bodys ability to take in and utilize oxygen - to a hotel room in Addis Ababa, Ethiopia. Visit the link in our profile to read more from @nytimessports, and follow along this #nytweekender as we share more photos by @urielsinai." By nytimes on Instagram.. ...
William C. Stanley, a cardiovascular physiologist who made connections around the world for his research and loved outdoor exercise, died Oct. 21 in Australia of a sudden coronary artery blockage. He was 56.
Exercise Physiologists at The Sports Injury Clinic Frankston 9783 9990. Specialising in PT, Bootcamps, Rehab, TAC, PACE & Workcover related conditions.
Exercise physiologists develop fitness and exercise programs that help patients recover from chronic diseases and improve cardiovascular function, body composition, and flexibility.
The average exercise physiologist salary in Wisconsin, United States is $49,616 or an equivalent hourly rate of $24. Salary estimates based on salary survey data collected directly from employers and anonymous employees in Wisconsin, United States.
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In addition, I think climate change is a more significant issue than almost any other environmental issue, because it has the potential to alter nearly all of them. Species are likely to disappear because the areas that plants grow probably wont shifts as far north as temperatures allow (temps shifts north, but the earths inclination isnt going anywhere), and water shifts and ocean changes will shift population a lot. Thus, its likely to change lots of things at once, each of which would be a significant issue in itself. Even if we dont care about environmental issues, there is more than enough human issues involved to make it important. Shifting water supplies and food growing areas are likely to lead to wars and conflicts; since the people who are poor now are likely to bear a significant portion of the costs without the resources to ameliorate the situation, wars are pretty likely. (The conflicts at global warming (GW) meetings over who pays and how are not a good sign - while you cant ...
We appreciate your assistance in evaluating Reactome. Your responses will give us an indication of the effectiveness of the Reactome website and tools, and areas in which improvement could be made. We would like to know a bit about your background and research interests and welcome your written comments and suggestions. The survey should take about 5 minutes to complete. The information you provide will never be made publicly available or shared with third parties. Participation in the survey is optional. However, five lucky participants who complete the survey will receive a Reactome T-shirt. You can access the survey at: https://www.surveymonkey.com/s/RV63355 Thank you for taking part. Regards, Robin Haw Robin Haw, PhD Scientific Associate Manager of Reactome Outreach Ontario Institute for Cancer Research MaRS Centre, South Tower 101 College Street, Suite 800 Toronto, Ontario, Canada M5G 0A3 Tel: 647-260-7985 Toll-free: 1-866-678-6427 http://www.oicr.on.ca,http://www.oicr.on.ca/, ...
This module aims to provide an understanding of the structure and function of key physiological systems of the human body. Human physiology is the study of how our body works in an integrated way. A central principle of human physiology is homeostasis, the maintenance of a relatively stable internal environment. Failure to maintain homeostasis disrupts normal function that may lead to disease (or pathophysiology). Students will be taught the key concepts of homeostasis in the physiological systems of the body, enabling the student to understand the consequences of pathophysiology to human health. Students will gain practical experience in assessing respiration and cardiac function during two separate laboratory based exercises. ...
We are interested in understanding how gene expression is encoded in genomes, and how to leverage this knowledge to understand the basis of genetic diseases. To this end, we employ statistical modeling of omics data and work in close collaboration with experimentalists. I will provide an overview of recent studies from our lab, covering work on RNA metabolism in S. pombe [1] and on mRNA stability in S. cerevisiae [2], and discussing the implications of TT-seq, a novel protocol suited to study nascent transcriptomes in higher eukaryotes [3]. I will also report on a recent pilot study where we established RNA-sequencing as a powerful companion tool to genome sequencing for pinpointing molecular causes of rare genetic disorders [4]. The talk will end with a discussion on future directions in computational modeling of cis-regulatory elements.. References [1] Eser. et al, Determinants of RNA metabolism in the Schizosaccharomyces pombe genome, Molecular Systems Biology, 2016 [2] Cheng, et al. ...
The Boston Childrens environment also provides the opportunity to interact with clinicians specializing in virtually every aspect of pediatric disease, as well as world-class researchers in related fields. Dr. Elizabeth Engle, MD, a Neurologist, combines genetic and molecular biological approaches to study congenital eye movement disorders. The Kreiman lab is interested in understanding how biological networks encode, process and transmit information. There are two main lines of research in the lab: (i) how circuits of neurons represent visual information and (ii) how gene expression is orchestrated, with a particular emphasis on gene expression in the nervous system. The lab uses a combination of mathematical, computational and experimental tools.. Our department has affiliations with leading subspecialists in pediatric ophthalmology, including Shizuo Mukai, MD, who has an interest in pediatric retina, and Dr. Hoguet, who specializes in both adult and childhood glaucomas. Ronald Hansen, PhD, ...
All cells in an animal contain the same set of genes, yet each cell has unique characteristics based on how those genes are actually used. My research is fundamentally focused on answering questions about how gene expression is regulated in different cell types and tissues throughout animal development and in response to environmental conditions, such as temperature and food availability. Most recently my research has focused on the role of microRNAs and cell signaling pathways in regulating gene expression during the development of fruit flies (Drosophila melanogaster).. Vassar students are involved in all aspects of my research. One current project in my lab involves studying how changes in nutritional status during development affects adult cuticle pigmentation. We have found that activation of the Insulin/Insulin-like and TOR signaling pathways leads to increased melanin production and we are currently exploring how these pathways might directly regulate key enzymes involved in melanin ...
My research interests in collaboration with Barry Gusterson and Torsten Stein have focused on mammary gland biology and cancer, in particular how gene expression in development during puberty, pregnancy and lactation relates to tissue invasion and stromal remodelling in cancer development. I also collaborate with Karen Blyth and Ewan Cameron in examining the role of the Runx genes in mouse mammary development and cancer.. Although my clinical research interests do include mammary tumours in cats and dogs, my main focus has been identification of serum biomarkers for other tumour types. This has included investigation of acute phase proteins, particularly C-reactive protein in lymphoid neoplasia, and use of the Glasgow Prognostic Score as well as identification as possible new proteins using electrophoresis and mass spectrometry. I have also looked at inflammatory cell ratios such as neutrophil: lymphocyte ratios in sarcomas and mast cell tumours and am currently interested in cell free DNA for ...
As summer draws near, people exercising outdoors from newcomers to top athletes should make adjustments or their workouts could suffer, says Marni Sumbal , a prominent exercise
Sorry, but the advert you were looking for has expired. To see more employment opportunities with Headquarters Army Recruiting and Training Division, please click here. Perhaps you were looking for something totally different? In that case, it might be best start a new job search from our Home Page. You might also find our Site Map useful too. ...
The term heart failure(HF) describes an abnormality of the cardiac structure/function that leads to failure of the organ to deliver oxygen sufficient in rate to the metabolising tissues, despite normal filling pressures. It is actually a blanket term that covers a broad range of pathologies, but usually presents with specific signs and symptoms; Breathlessness Ankle swelling Fatigue…
USDAs Sid Abel[*] and Doug McKalip[†] just briefed me on the new regulatory framework that is shaping up for the oversight of plants modified by what they are now calling
COMODI is an ontology to describe the differences between two versions of a computational model. The ontology terms specify the type of change for each detected difference. Usually, a combination of COMODI terms from different branches is necessary to characterise a change sufficiently. We currently use COMODI for the description of changes between two versions of the same model, either encoded in SBML or in CellML. However, COMODI terms can also be applied to differences detected between models in any other encoding format, including even code from proprietary languages such as MATLAB.. The COMODI ontology was developed based on a manual study of changes in versions of curated SBML models from BioModels and in versions of CellML models from the Physiome Model Repository. These models, however, were all implemented in core SBML and core CellML. That means, we did not consider extensions. In the future, the study should be extended to also cover SBML models that use SBML extension packages. ...
Model development and archiving support at physiome.org provided by the following grants: NIH/NIBIB BE08407 Software Integration, JSim and SBW 6/1/09-5/31/13; NIH/NHLBI T15 HL88516-01 Modeling for Heart, Lung and Blood: From Cell to Organ, 4/1/07-3/31/11; NSF BES-0506477 Adaptive Multi-Scale Model Simulation, 8/15/05-7/31/08; NIH/NHLBI R01 HL073598 Core 3: 3D Imaging and Computer Modeling of the Respiratory Tract, 9/1/04-8/31/09; as well as prior support from NIH/NCRR P41 RR01243 Simulation Resource in Circulatory Mass Transport and Exchange, 12/1/1980-11/30/01 and NIH/NIBIB R01 EB001973 JSim: A Simulation Analysis Platform, 3/1/02-2/28/07.. ...
We are delighted to announce that Craig Franklin (University of Queensland, Australia) has been appointed as the next EiC of JEB, starting on 1 August. With research interests in animal ecophysiology and conservation physiology, Craig is already familiar with the journal, having been a Monitoring Editor since 2011. We are looking forward to welcoming him in his new role.. ...
This Department have three modules focus on the basic principles of Physiology and discuss in detail the development and normal functions of the ten physiological systems within the body. The courses undertaken over the first three semesters are designed to lay a solid foundation and review in detail concepts in Physiology essential in understanding the patho-physiology of diseases. Upon completion of this course students should be versed in the genetic aspects of early development as well as the interactions that occur in development leading to the formation of the ectoderm, mesoderm and endoderm and the further differentiation of these layers...
The Department of Microbiology and Physiological Systems (MaPS) was founded in 2010, and is the product of a merger between two departments, one focused on microbiology, genetics, and immunology, and the other focused on physiology. Capitalizing on the strength of the respective scientific research programs, the resulting department has strong and synergistic expertise in bacterial and viral pathogenesis, immunology, signal transduction, and fundamental cellular physiology. Current departmental research targets include viral and bacterial pathogens affecting the nervous, respiratory, and digestive systems. The mission of the new department is to address important biological questions broadly relevant to infectious disease and encompassing multiple levels of biological organization, including an understanding of pathogen effects on their target organ systems. This collection showcases the journal articles and other publications and presentations written by faculty and researchers of the Department of
Fortunately, there are natural biological processes that facilitate our recovery from stress. A process called allostasis attempts to get all of the physiological systems back to their steady state after the stress response.
1750 words Humans are adapted to numerous ecosystems on earth. This is only possible due to how our physiological systems interact with the environment in a homeodynamic way. This allowed us to spread across the globe, far away from our ancestral home of Africa, and thusly certain adaptations evolved in those populations---which was driven by our intelligent…
Dr. John Sheridans research includes peripheral physiological systems and behavior, neuroendocrine regulation of gene expression in inflammatory and immune responses here at Ohio State.
23 Manager Cardiovascular Lab $60,000 jobs available in Ohio on Indeed.com. Registered Nurse - Catheterization Lab, Clinical Trial Administrator, Exercise Physiologist and more!
By Nancy Clark, MS RD CSSD. Like it or not, every one of us is getting older, day by day. As a fitness exerciser or an athlete, you might wonder how aging impacts performance-and what you can do to retain youthful fitness. The following information is gathered from a workshop (www.sportsnutritionworkshop.com) presented by Dr. William Evans, an exercise physiologist and expert on aging, muscles, and protein. The following information can help you chart a healthy course into your future.. • The average person loses about 1% of their fitness per year. Aerobic capacity goes down, particularly after age 60. Staying active helps maintain a slighter higher ability to uptake oxygen than a non-athlete, but the rate of loss is the same.. • Muscle is an active tissue (as compared to body fat). The more muscle you have, the more calories you can eat without getting fat. Yet muscle loss creates a subtle change in metabolism that can contribute to weight gain with aging.. • We lose muscle as we age, ...
The French physiologist Pierre Cabanis, who lived from 1757 to 1808, was a man ahead of his times. Consider his words, quoted below, in terms of their application to the values of mental stimulation and continuing education: Impressions arriving at the brain make it enter into activity, just as food falling into the stomach...
British physiologist develops a universal formula that keeps human organs functioning outside the body, with support from Innovate UK.
But hes wrong perhaps dangerously wrong. Like many other outdoor athletes of his generation, Jim is overlooking a tenacious enemy that will linger inside him long after he sweats away the calories. One that, without a change in diet, will grow even more worrisome as he exercises into his thirties and forties. And someday, when Jim appears to be in prime middle-age condition, it just might kill him. The culprit is arterial plaque a by-product of high levels of low-density lipoprotein (LDL) cholesterol, which lurks in foods rich in saturated fat. Over years of après-sport cheeseburgers and Saturday-morning doughnut runs, this plaque builds up on the walls of arteries and hardens. Left unchecked, it will gradually strangle the flow of blood to the heart or even break off during a routine workout and fatally block an artery.. Thats exactly what happened to Ed Burke. Three years back, Burke the renowned Colorado Springs based exercise physiologist who consulted on the training programs of cycling ...
Hahns Petty, an exercise physiologist, recommends exercise to enhance your quality of life and help regulate hormonal imbalances.
Body composition can be more useful than weight alone when assessing changes to your body. Exercise physiologist Ava Kerr explains what you need to know.
SAM (sekvenssammenstilling og modellering) er en pakke av fleksible programvareverktøy som foredler og skaper lineære skjulte Markov-modeller for biologisk sekvensanalyse
May 25-27, 2010 - Oracle Offices Ottawa Canada This Summit will offer interested committers an opportunity to dive deeper into the implementation. Long time and new committers, contributors, and consumers will get together and exchange information about the project with the goal of increasing the shared knowledge and capturing it in updated architecture and design documents. Program Committee: Doug Clarke, Shaun Smith, Peter Krogh ...
Page contains details about Na0.44MnO2 nanoplates . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Praxair, Inc. (NYSE: PX) today announced the signing of an agreement with Proton Energy Systems, Inc. to become the exclusive distributor in Canada and a U.S. distributor for Protons advanced on-site hydrogen generation systems for the electric utilities industry and other applications.
Nowadays PEMFC with hydrogen fuel has developed to commercialize to replace the conventional machine. Several limitations in PEMFC commercialization are its low efficiency, viability of hydrogen fuel supply and problem of controlling fuel and water as reaction products. Effective effort to increase efficiency and water management include elevating temperature of PEMFC operation near water boiling point to increase energy produced, prevent water flooding, enhanced cooling efficiency and also the possibility to use hydrogen and air under lower humidity in order to make simples PEMFC design. But at elevated temperature and low relative humidity, Nafion membrane that during the time still used as electrolyte will shrink and at high humidity and high temperature above 80oC membrane will swell and irreversibility decay occur. Membrane shrinking and swelling will reduce PEMFC performance. The objective of this study is to investigate the usage of Nafion-SiO2-PWA nanocomposite membrane NS10W, NS15W and ...
Aleutian mink disease virus (AMDV) readily spread within farmed mink and causes chronic infections with significant impacts for welfare and economy. In the present study a currently circulating Danish AMDV strain was used to induce chronic experimental infection of farmed mink.PCR was used to detect viral DNA in full blood, organs, faeces and oro-nasal swabs weekly for the first 8 weeks and then biweekly for another 16 weeks after AMDV challenge inoculation of wild type mink. The mink (n=29) was infected and seroconverted 2-3 weeks after AMDV inoculation and AMDV antibodies persisted during the maximum experimental period of 24 weeks. Viraemia and faecal excretion of viral DNA was detected in the mink (n=29) at various and intermittent time intervals. Excretion of viral DNA in oro-nasal swabs was detected for 1-8 weeks in 21 mink. This highlights the risk of transmitting AMDV between infected farms.PCR was successfully used to detect viral DNA in organs 8, 16 and 24 weeks after AMDV inoculation ...
Mark Colello, exercise physiologist at Southington Care Center, will present The Path to Wellness, on Friday, May 22 at 2 p.m. at Bristol Public Library, 5 High St. This free program details the stepping stones to take on the journey to wellness and a happier, healthier life. For more information, contact 860-584-7790. Southington Care Center, which offers skilled nursing and rehabilitation services, is a not for profit member of Hartford HealthCare Senior Services. To learn more about Southington Care Center, visit southingtoncare.org.
Conclusions Cardiac Physiologists are a group of the non-cancer workforce who are potentially neglected with regards to end of life communication skills training. We would encourage other services around the country to provide this training to improve the end of life care for patients with ICDs.. Interactive role play appears to have been a successful method to provide this training.. The joint educational programme between Cardiology and Palliative Care facilitated learning from shared differing experiences and helped develop relationships between the teams. ...
The average exercise physiologist salary in Arkansas, United States is $43,318 or an equivalent hourly rate of $21. Salary estimates based on salary survey data collected directly from employers and anonymous employees in Arkansas, United States.
We have reconstructed the events that led to the evolution of a key physiological innovation underpinning the large adaptive radiation of fishes, namely their unique ability to secrete molecular oxygen (O2). We show that O2 secretion into the swimbladder evolved some 100 million years after another O2-secreting system in the eye. We unravel the likely sequence in which the functional components of both systems evolved. These components include ocular and swimbladder countercurrent exchangers, the Bohr and Root effects, the buffering power and surface histidine content of hemoglobins, and red blood cell Na+/H+ exchange activity. Our synthesis reveals the dynamics of gains and losses of these multiple traits over time, accounting for part of the huge diversity of form and function in living fishes.. ...
An electrical interconnection is provided between a patient and physiological sensing or monitoring equipment. A permanent electrode is formed with a thin flexible housing which encases an electrical connector such as a pellet or nodule so that a portion of that connector is externally exposed on one surface. A disposable pad formed of a thin flexible base frame has a central bore and a double-faced adhesive disc on one side for attachment of the electrode surface containing the connector and concurrently retaining a conductive gel within the disposable pad for electrical communication with the electrode conductor. The adhesive on the opposite surface of the disposable pad is adapted to secure the pad to a selected area of the skin of the patient.
The Statistics Seminar speaker for November 5, 2014 will be Rachael Hageman Blair, from the University at Buffalo.. Title: Belief Propagation in Genotype-Phenotype Networks. Abstract: Graphical models have proven to be a valuable tool for connecting genotypes and phenotypes. Structural learning of phenotype-genotype networks has received considerable attention in the post-genome era. In recent years, a dozen different methods have emerged for network inference, which leverage natural variation that arises in certain genetic populations. The structure of the network itself can be used to form hypotheses based on the inferred direct and indirect network relationships, but represents a premature endpoint to the graphical analyses. In this work, we extend this endpoint. We examine the unexplored problem of perturbing a given network structure, and quantifying the system-wide effects on the network in a node-wise manner. The perturbation is achieved through the setting of values of phenotype node(s), ...
This interview first featured in Development. Mike Levine, director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University, is a developmental biologist who has dedicated his career to understanding how gene expression is regulated during development. Some of his most significant research, such as the co-discovery of the homeobox genes and his work on[…] ...
MAHRENI, Mahreni and MOHAMAD, Abu Bakar and KADHUM, Abdul Amir Hasan. and Daud, Wan Ramli Wan (2010) NANOCOMPOSITE ELECTROLYTE MEMBRANE FOR MODERATE TEMPERATURE AND LOW RELATIVE HUMIDITY HYDROGEN PROTON EXCHANGE MEMBRANE FUEL CELL (HPEMFC) APPLICATlON. Departement Of Chemical Engineering, ITB. ...
ABSTRACT. Chronic nasal disease is a common problem in dogs. To determine the aetiology, a retrospective study in 75 dogs with persistent and chronic nasal disease was done. All dogs were evaluated by means of survey nasal radiographs, antegrade and retrograde rhinoscopy, bacterial and fungal cultures, and histopathology. A definitive diagnosis was made in 74/75 cases (98.6 %). Nasal neoplasia was the most common diagnosis (46.7 %), median age 108 months, followed by lympho-plasmacytic rhinitis (20 %), median age 112 months, and fungal rhinitis (10.7 %), median age 53.5 months. Other diagnoses included nasal foreign body (5.3 %), median age 51 months, and primary bacterial rhinitis (6.7 %), median age 116.5 months. Rare aetiologies identified were nasal polyps, granulomatous rhinitis, oro-nasal fistula and naso-pharyngeal stenosis. This study showed that by using a structured combination of survey radiography, rhinoscopy, cultures and histopathology, a diagnosis could be made in dogs with ...
Research Summary. My laboratory has developed powerful genomics methods to map how protein regulators control gene expression programs in healthy and diseased cells. These methods were first used in yeast to discover how gene expression programs are controlled by transcription factors, chromatin regulators, and signaling pathways. Among the key concepts that emerged from these studies is that transcription factors that control cell state typically regulate their own gene expression, that chromatin modifications span active genes in a spatially specific manner, and that signaling pathways have terminal kinases that generally occupy the set of genes they regulate.. These concepts and genome-wide methods have been used recently to map the transcriptional regulatory networks that control pluripotency and self-renewal in human embryonic stem cells, to determine how epigenetic regulators contribute to the embryonic cell state, and to reveal initiation and elongation control mechanisms in mammalian ...
During this study, we observed that both average and maximum leak were associated with the development of central apnea during CPAP titration, particularly in subjects using a nasal mask. These findings were independent of the applied CPAP level and comorbidities which were balanced between groups, which may have confounded prior reports of complex apnea. We believe that nasal masks may be particularly problematic in predisposing to central apneas since the fresh gas can easily wash out the anatomical dead space when exiting through the mouth. However, oro-nasal masks may worsen pharyngeal mechanics by forcing the mandible posteriorally. Thus, treatment decisions may need to be individualized at least for certain patients.. The development of central apnea while on CPAP has a number of important physiological implications. The evolutionary advantage of anatomical dead space has often been questioned, since the "wasting" of 25% to 30% of each breath would seem inefficient upon initial ...
TY - JOUR. T1 - Electrochemical characterization of polymer electrolyte membrane fuel cells and polarization curve analysis. AU - Mohsin, Munazza. AU - Raza, Rizwan. AU - Mohsin-ul-Mulk, M. AU - Yousaf, Abid. AU - Hacker, Viktor. PY - 2019/10/28. Y1 - 2019/10/28. N2 - This paper presents the diagnostic results of single polymer electrolyte membrane fuel cell assemblies characterized by polarization curves. Single PEM fuel cell assemblies were investigated through accelerated voltage cycling test at different values of relative humidity. The fuel cells are tested at different humidity level. The cells are discussed in this paper with analysis results at different relative humidity at atmospheric pressure. This represents a nearly fully humidified, a moderately humidified, and a low humidified condition, respectively. This technique is useful for diagnosing the main sources of loss in MEA development work, especially for high temperature/low relative humidity operation where several sources of ...
Astronauts in space suffer from an increased bone loss which is mainly related to the absence of gravitational forces. This increased bone reduction is accompanied by an higher concentration of calcium in urine and in this respect enhancing the risk of renal stones. Due to the fact, that bones´ regeneration does not occur rapidly even after returning to earth, astronauts face an increased risk of osteoporosis.. Nutritional factors such as a deficient intake of calcium, energy and fluid and the abundant intake of table salt exhibit additional negative effects on bone. Results of several studies consistently show the negative effects of acids on bone (increased bone loss). With respect to space missions of longer duration one big challenge is the development of countermeasures for the negative consequences of weightlessness on bone.. As not all needed experiments for the development of countermeasures can be conducted in space, simulation models of weightlessness such as 6° Head- Down- Tilt- ...