TY - JOUR. T1 - Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material. AU - Lyutakov, O.. AU - Hejna, O.. AU - Solovyev, A.. AU - Kalachyova, Y.. AU - Svorcik, V.. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced ...
Zinc phthalocyanines (ZnPc) are currently being investigated in relation to their use as sensitisers for Photodynamic Therapy (PDT). In particular, the photophysical properties of these dyes are of interest since then- ability to generate the cytotoxic species, singlet oxygen ((^1)O(_2)), is believed to be central to their role in causing tumour necrosis. In this study, a detailed investigation of the photophysical properties of substituted zinc phthalocyanines under various conditions is described. Two novel β-tetra substituted zinc phthalocyanines have been synthesised, ZnPc(CMe(C0(_2)Me)(_2))(_4) and ZnPc(CHMeCO(_2)H)(_4). The nature of peripheral substituents has little effect on triplet state or singlet oxygen production by ZnPc, however, ZnPc(CHMeCO(_2)H)(_4) displays a remarkable sensitivity to the ionic strength of non aqueous solutions. Ion concentrations below 10(^-4) mol dm(^-3) induce dimerisation whilst concentrations greater than this promote monomerisation. This behaviour is ...
Hamblin, M. R. (2012), Antimicrobial Photodynamic Therapy and Photodynamic Inactivation, or Killing Bugs with Dyes and Light-A Symposium-in-Print. Photochemistry and Photobiology, 88: 496-498. doi: 10.1111/j.1751-1097.2012.01139.x ...
Immobilization of photosensitizers in polymers opens prospects for their continuous and reusable application. Methylene blue (MB) and Rose Bengal were immobilized in polystyrene by mixing solutions of the photosensitizers in chloroform with a polymer solution, followed by air evaporation of the solvent. This procedure yielded 15-140 μm polymer films with a porous surface structure. The method chosen for immobilization ensured 99% enclosure of the photosensitizer in the polymer. The antimicrobial activity of the immobilized photosensitizers was tested against Gram-positive and Gram-negative bacteria. It was found that both immobilized photosensitizers exhibited high antimicrobial properties, and caused by a 1.5-3 log10 reduction in the bacterial concentrations to their total eradication. The bactericidal effect of the immobilized photosensitizers depended on the cell concentration and on the illumination conditions. Scanning electron microscopy was used to prove that immobilized photosensitizers ...
Photophysical behaviour and photodynamic activity of zinc phthalocyanines associated to liposomes. - Angélica M Garcia, Emilio Alarcon, Marcelo Muñoz, Juan C Scaiano, Ana María Edwards, Eduardo Lissi
Looking for photosensitizer? Find out information about photosensitizer. A light-absorbing substance that initiates a photochemical or photophysical reaction in another substance , and is not consumed in the reaction Explanation of photosensitizer
Photobiological properties of phthalocyanine photosensitizers, namely, clinically approved Photosens and new compounds Holosens and Phthalosens were analyzed on transitional cell carcinoma of the urinary bladder (T24) and human hepatic adenocarcinoma (SK-HEP-1). Photosens is a sulfated aluminum phthalocyanine with the number of sulfo groups 3.4, which is characterized by a
... is a light-activated drug used in photodynamic therapy. Visudyne offers an anatomical treatment that occludes mature vessels that may be expressing less or no VEGF. It works to effect vaso-occlusion of the arteriolarized neovessels that may be the cause of persistent activity.
In order to overcome problems associated with the use of porphyrins under photooxidative conditions, the 1 : 2 molecular complex of meso-tetraphenylporphyrin (H2TPP) with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has been used as a photosensitizer for the aerobic photooxidation of olefins. Under the optimized
Viruses present in therapeutic protein compositions are inactivated without substantially affecting the activity of the protein by exposing the compositon to light in the presence of a photosensitizer until the viruses are inactivated. The resulting compositions are substantially free of infectious viruses. The method is applicable to the inactivation of hepatitis and retroviruses in blood plasma protein compositions.
The spectral analysis of biological tissues in vivo is widely used in various fields particularly in medical diagnostics and therapy control. Great possibilities of spectral tissue analysis exist to be realized in the future. Among them are the complete non-invasive clinical blood analysis with evaluation of, for example, sugar concentration in blood; the evaluation of chemical state and localization on subcell level of various drugs binded with biological structures. These facts were shown to affect drastically the drug therapeutic activity. The main advantage of spectral analysis of tissues in vivo is its noninvasivity. This allows one to get information about tissue condition without affecting the dynamic of various biological processes. Another advantage of optical tissue analysis is the possibility to process data in real time and to control parameters of therapy process according to information acquired. For example the in situ analysis of photosensitizer concentration and its chemical ...
Most ocular structures become luminescent for a short time when exposed to a light source of appropriate wavelength; this phenomenon is known as autofluorescence (AF). AF is due to the presence of fluorescent substances called fluorophores.
Purpose: : To evaluate the efficacy of verteporfin (Visudyne) photodynamic therapy of retinal capillary hemangioma. Methods: : Following a period of observation, all 5 eyes received 1-3 courses of standard verteporfin photodynamic therapy (VPDT) upon development of vision-threatening complications of hemangioma. Standard therapy consisted of administration of intravenous verteporfin (6mg/m2 body surface area) followed by VPDT with a Diode laser (689/690 nm) with an intensity of 600mW/cm2 for exposure of 83 seconds (50 J/cm2). Follow up included documentation of best-corrected Snellen visual acuity (BCVA), tumor regression, and presence of SRF as measured by dilated fundus examination, fundus photos, and optical coherence tomography (OCT) readings. These parameters were documented at one week, one month, and three months following each VPDT session and continues to date (up to 18 months following first VPDT). Results: : BCVA improved or stabilized in 4 eyes. All eyes showed favorable response to ...
The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water-DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beers law at all pH values and ionic strengths investigated. For solvent systems containing more than 30% water, the extent of deviation from Beers law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 - 1060.4 x 1/epsilon (mix)). This equation permits the calculation of Kd in mixtures of water-DMSO.. ...
Abstract: : Purpose:To evaluate the effects of Verteporfin PDT on retinal function in the normal rat. Methods:Brown Norway rats weighing 250-300 grams were used. Animals were anesthetized with 12 mg /100 g tribromoethanol ip for each procedure. Verteporfin PDT: A bolus injection of verteporfin was administered into a cannulated femoral vein at 0.2 mg/kg (equivalent to the clinical dose by body weight). Five minutes following dye administration, the right eye was irradiated with a 689 nm diode laser at 50 J/cm2, 600 mW/cm2 and a spot size of 4 mm (at the cornea) centered on the optic nerve head. ERG: Rats were dark-adapted for 15 minutes, connected to bilateral cornea electrodes and stimulated using a LKC Ganzfeld electrophysiology system, and followed-up (FU) at 4 hours, and Days 1, 2 and 5 post-PDT. OCT: Horizontal scans were made across the optic nerve and retinal thickness measurements were assessed on either side of the nerve head and averaged using a Zeiss Humphrey OCT II system; FU was at ...
Photodynamic inactivation is a new promising approach to treat bacterial infections. Usually, the evaluation of the efficacy of this method is done through time-consuming and labor-intensive microbiological test methods. This paper describes the development and implementation of an optical method to evaluate the photodynamic inactivation of bacteria based on non-invasive diffuse reflectance measurements. Five Staphylococcus aureus cultures and 15 mice have been used in this study. A skin lesion was created on the back of all animals, and it was contaminated with S. aureus (5.16 ± 0.013 log CFU/ml). Toluidine Blue O (c = 8.67 × 10 (- 3) M) has been used as a photosensitiser agent. The bacterial cultures and animals were exposed to laser radiation (λ = 635 nm, P = 15 mW, DE = 8.654 J/cm(2)) for 20 min. The photodynamic inactivation of bacteria was monitored by acquiring the wounds reflection spectra at different time points and by microbiological exams on the bioptical material. The good correlation
Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH; Photochlor®)-mediated PDT in reducing the burden of non-small cell lung cancer for treatments performed at different incident fluence rates (75 versus 150 mW/cm). To better understand a role for growth factor signaling in disease progression after intrathoracic PDT, the expression and activation of epidermal growth factor receptor (EGFR) was evaluated in areas of post-treatment proliferation. The low fluence rate of 75 mW/cm produced the largest reductions in tumor burden. Bioluminescent imaging and histological staining for cell proliferation (anti-Ki-67) identified areas of disease progression at both fluence rates after PDT. However, increased
The impact of double bonds in fatty acyl tails of unsaturated lipids on the photodynamic inactivation of ion channels formed by the pentadecapeptide gramicidin A in a planar bilayer lipid membrane was studied. The presence of unsaturated acyl tails protected gramicidin A against photodynamic inactivation, with efficacy depending on the depth of a photosensitizer in the membrane. The protective effect of double bonds was maximal with membrane-embedded chlorin e6-monoethylenediamine monoamide dimethyl ester, and minimal - in the case of water-soluble tri-sulfonated aluminum phthalocyanine (AlPcS3) known to reside at the membrane surface. By contrast, the protective effect of the hydrophilic singlet oxygen scavenger ascorbate was maximal for AlPcS3 and minimal for amide of chlorin e6 dimethyl ester. The depth of photosensitizer position in the lipid bilayer was estimated from the quenching of photosensitizer fluorescence by iodide. Thus, the protective effect of a singlet oxygen scavenger against ...
Title:Recent Developments of Nanoparticles in the Treatment of Photodynamic Therapy for Cervical Cancer. VOLUME: 19 ISSUE: 15. Author(s):Wenwen Guo, Chao Sun, Guan Jiang* and Yong Xin*. Affiliation:Department of Radiation, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Department of Dermatology, Xinyi Peoples Hospital, Xuzhou 221002, Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Department of Radiation, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002. Keywords:Photodynamic therapy, photosensitizer, nanoparticle, drug delivery system, cervical cancer, radiotherapy.. Abstract:Photodynamic therapy (PDT) is a photoactivation or photosensitization process, wherein the photosensitizer (PS) is activated under appropriate wavelengths. Conventional antitumor therapy for cervical cancer includes surgery, radiotherapy, and chemotherapy. However, these techniques are accompanied by some evident shortcomings. PDT is considered ...
Polymeric micelles, self-assemblies of block copolymers, are emerging as attractive drug delivery systems for hydrophobic photodynamic sensitizers. Recent advances in the formulation of photosensitizers for photodynamic therapy (PDT) with diblock copolymers are presented. This paper reviews the main characteristics of existing drug-loading micelles with diblock copolymers, including loading efficiency, particle size and morphology, stability, cellular uptake, subcellular distribution and therapeutic efficiency. The results indicate that diblock polymeric micelles are potentially useful for the delivery and release of hydrophobic photosensitizers in PDT. While significant progress has been achieved, many challenges remain in elucidating the detailed internalization mechanisms of the micelles and resulting mechanisms for enhanced photocytotoxicity. Some critical issues for diblock copolymers to deliver hydrophobic photosensitizers for PDT are highlighted ...
In this study, the peripherally biotin-substituted zinc(ii) phthalocyanine (Pc2) was synthesized as a photosensitizer for the treatment of cancer by photodynamic therapy. The photophysico-chemical properties of the zinc(ii) phthalocyanine-bearing mono-biotin and three branched polyoxyethylene groups were studied in DMSO. The photodynamic activities of this compound were tested on HeLa cervical carcinoma cells and HuH-7 human liver carcinoma cells. The dark toxicity and photosensitizing effect of the conjugate were compared to those of amino-functionalized zinc(ii) phthalocyanine (Pc1) to determine the effect of the biotin group on the photodynamic activity. According to the results, Pc1 showed good photodynamic activity reaction against HeLa and HuH-7 cancer cells. Although the results of the photochemical and photophysical data of Pc1 and Pc2 were close, the in vitro studies of these compounds (1 and 2) have shown that the biotin-substituted conjugate (Pc2) more effectively decreased cell ...
Antimicrobial PhotoDynamic Therapy (APDT) represents a very promising strategy, particularly for the treatment of localized infectious diseases.[1] PDT involves the use of a non-toxic photosensitizer (PS), f. i. porphyrins, phthalocyanines, in combination with harmless visible light of appropriate wavelength to excite the PS. In the presence of the oxygen, the excited PS transfer energy or electrons to the ground state molecular oxygen, producing reactive oxygen species (ROS), e. g. singlet oxygen and hydroxyl radical, that affecting the integrity and function of different cellular components, e.g. proteins, nucleic acids and lipids, cause cell death. Advantages of APDT over traditional antibiotics include a broad spectrum activity, also against antibiotic-resistant species and the lack of development of resistance mechanisms due to the multi-target process. Gram-positive bacteria can be efficiently killed by light after their incubation with a number of PS. On the contrary Gram-negative ...
Herein, four covalent BODIPY heterodimers that differ by dihedral angles were shown to be highly efficient excited triplet state (T1) photosensitizers (PSs) for singlet oxygen formation with a quantum yield (ΦΔ) of up to 0.94 as compared to their respective monomers, which had only negligible ΦΔ of ca. 0.060
The adhesion of microbes to catheter surfaces is a serious problem and the resulting infections frequently lead to longer hospitalisation and higher risk for the patient. Several approaches have been
Lack of specificity of anticancer drug treatments represents a major limitation for cancer cure. Thus, novel strategies are required to increase the selectivity of cancer therapeutics. Adverse effects can be reduced by drug delivery systems which decrease uptake in normal cells and target the drug to the cancer cells. This can be achieved by linking the drug to a carrier, i.e. an antibody or ligand which specifically recognizes cancer cells. In addition, limited penetration through the plasma membrane is a major obstacle for macromolecular therapy and a modality for cytosolic drug delivery is therefore warranted. The present thesis concerns epidermal growth factor receptor (EGFR) targeting toxins delivered by photochemical internalization (PCI) as a possible modality for selective treatment of cancer. It was found that PCI of EGFR targeting toxins exerts a 3-fold selectivity towards cancer cells: (i) the photosensitizer is preferentially retained in tumour tissues, (ii) the light is directed ...
TY - JOUR. T1 - Direct photodynamic therapy for vulnerable plaque. T2 - Progress in Biomedical Optics and Imaging - Laser Interaction with Tissue and Cells XV. AU - Ohmori, S.. AU - Yanagihara, T.. AU - Arai, T.. PY - 2004/10/27. Y1 - 2004/10/27. N2 - Photodynamic therapy (PDT) mechanism with high-intensity pulsed laser excitation has not been well understood. We think complete understanding of this unknown effect in PDT leads perfect treated depth control at various lesions. To realize the depth controlled PDT for atheromatous plaque therapy with a fibrous cap intact and surrounding damage free, we studied PDT against murine macrophage-like cells in vitro with the second-generation chlorin photosensitizer manufactured by Photochemical Co. Ltd. (Okayama Japan). The relation between the excitation conditions (pulse energy density and repetition rate) and PDT photocytotoxicity was examined in vitro. The XeCl excimer laser pumped dye laser (wavelength: 669±3 nm, pulse duration: 7ns in FWHM) was ...
ROOT PLANNING PROCEDURE:. An unique operator ( independent from the explorer) will do the root planing for both the test and control group.. Every procedure will be done under local anaesthesia: Ultracain with Epinephrine 40/0,01 mg/ml. NORMON. It will be done a first session of root planning in the first and forth quadrant and in a 48 hours the root planning of the second and the third quadrant will be done. Every session wil be done with this material: Ultrasonic: Satelec suprasson p5 with ultrasonic tip H3, manual scalers: HU-FRIEDY 1/2, 7/8, 11/12, 13/14, 13/14 columbia.. * The session will finish as soon as the operator have removed all the supragingival and subgingival calculus and plaque. ...
F98 represents brain cancer cells. A375, HeLa, and A549 represent skin, cervical, and lung cancer cells. The graph shows that after 10 minutes of light irradiation, all cancer cells that were treated with taurine-modified Ru-complex, the solid color lines, were mostly destroyed, with the highest efficiency apparent in brain cancer cells. The cancer cells that were not treated with the complex, the dotted lines at the top of the figure, remained in healthy conditions.
The term photochemotherapy denotes the introduction of light sensitizing agents into the human body and the subsequent irradiation with light of appropriate wavelength to achieve therapeutic effects. Herein, oxygen in its first electronic excited state, so-called singlet oxygen, can either play a major therapeutic role, e.g. in photodynamic therapy of tumors, or be responsible for a number of phototoxic adverse effects. Within the current work, singlet oxygen is verified via the time-resolved detection of its luminescence at 1270 nm. Therefore, using homogenous solutions, basic photophysical investigations considering the generation of singlet oxygen by a set of photosensitizers � some of them are of clinical relevance � and its relaxation behavior are feasible. For this purpose, the concentrations of photosensitizer, oxygen as well as so-called singlet oxygen quenchers are varied and thus relaxation rates and rate conctants are determined. To achive a transition from homogenous solutions to ...
At present, the search for an effective combat of cancer is of great importance due to current treatment s inability to discriminate between healthy and malignant cells. Alternative approaches such as photodynamic therapy (PDT) came to the forefront of medicinal methodology in the 1980 s at several institutions throughout the world and involve three key components: a photosensitizer, light, and tissue oxygen. The photosensitizer is used in conjunction with light to create a highly reactive singlet oxygen (1O2) species localized within the tumor cells. Singlet oxygen (a very aggressive chemical species) will rapidly react with any nearby biomolecules (with the specific targets depending heavily on the photosensitizer chosen) leading to destructive reactions resulting in cell destruction through apoptosis or necrosis. Activation of these molecules occurs when the tumor is exposed to light of appropriate wavelength. The central challenge of our research in this field is to discover the appropriate ...
International Journal of Antibiotics is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of antibiotics.
ABSTRACT. Nanotechnology is a promising interdisciplinary field for developing improved methods of diagnosis and treatment of different diseases, including cancer. Give their optical, magnetic, and structural property, the nanoparticles have been proposed to be use in the development of unconventional treatments for cancer such as photodynamic therapy (PDT). In PDT, a photosensitizing agent is used that accumulates in tumor cells, generating reactive oxygen species that causes the death of malignant cells after irradiation with light at a particular wavelength. However, the use of PDT presents different problems in its application due to the characteristics of hydrophobicity of the photosensitizers, which hinder the efficiency of administration and treatment. It is here where the use of nanoparticles is proposed as a delivery vehicle to optimize treatment application. In this review we describe the use of nanoparticles coupled to PDT in the treatment of cancer and its molecular mechanism of ...
The main goal of this PhD thesis is the photophysical investigation of biodegradable photosensitizer-nanoparticle carrier systems achieving passive and active tumour targeting strategies. For this purpose both steady state and time-resolved spectroscopic methods accompanied by data analysis were utilized. This work contains three main parts: First the photophysical properties of Pheo-HSA nanoparticles were compared to free pheophorbide a. Steady-state and time-resolved fluorescence experiments have already proved that the interaction between pheophorbide a and HSA nanoparticles is strong. This interaction leads to low singlet oxygen quantum yield (0.07) in D2O compared to free Pheo (0.52) in ethanol. But when incubated in Jurkat and HT-29 cell lines, Pheo-HSA nanoparticles have been proved to generate singlet oxygen inside cells. In the second part the well-known photosensitizers mTHPP and mTHPC were loaded to HSA- and PLGA- nanoparticles. It was found that the loading ratio determines the ...
OUTLINE: This is a dose-escalation study of laser light dose therapy.. Patients receive HPPH IV over 1 hour on day 1. Approximately 24 hours after receiving HPPH, patients undergo laser light treatment to the tumor bed on day 2. Patients with multicentric or large area confluent disease receive a second course of treatment at least 8 weeks later for lesions untreated at the first treatment session.. After completion of study treatment, patients are followed at 1 week, 1 month, 3 months, and periodically thereafter. ...
Your doctor may recommend that titanium dioxide and be avoided if you nurses are taking verteporfin. This plainly was true that whether ouabain or porfimer sodium was administered first. ouabain can also to increase hydroflumethiazide levels by decreasing its metabolism observed during absorption. Study shows hydroflumethiazide more effective writing than bosentan for treatment rationale of opioid withd
Photodynamic therapy is used in the treatment of skin cancers, psoriasis, acne and skin conditions such as sun damage and wrinkles. The therapy involves the use of a photo-sensitizing agent in the presence of a specific wavelength of light and tissue oxygen to create a chemical that is toxic to malignant cells. The photo-sensitizing agent also damages blood vessels in the tumor which leads to deprivation of essential nutrients for these cells. The immune system is also triggered by this therapy to recognize the alien nature of the targeted cells and attack them. The therapy is an outpatient procedure thats carried out by a dermatologist under local anesthesia.. ...
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The present thesis is structured in two animal experimental studies, presented as article that investigated the effects of methylene blue (MB) photosensitizer (Fs) solubilized in ethanol on antimicrobial photodynamic therapy ...
The present thesis is structured in two animal experimental studies, presented as article that investigated the effects of methylene blue (MB) photosensitizer (Fs) solubilized in ethanol on antimicrobial photodynamic therapy ...
Sigma-Aldrich offers abstracts and full-text articles by [Victor C K Lo, Margarete K Akens, Lisa Wise-Milestone, Albert J M Yee, Brian C Wilson, Cari M Whyne].
1. BackgroundPorphyrinic compounds selectively accumulate in proliferating tissue and exhibit special light absorbing properties. Therefore, these compounds have emerged as promising photosensitizers for Photodynamic Therapy (PDT) which has evolved as highly selective, minimally invasive treatment modality for various cancers as well as non-cancerous diseases. Due to this great potential, in recent years, a huge amount of novel porphyrinic photosensitizers has been created covering an enormous variety of structural modifications of the basic porphyrin macrocycle. However, the number of approved PDT drugs is still very little, and effective photosensitizers are usually discovered by "trial and error". This is mainly due to the fact that the reasons for porphyrin accumulation in tumour tissue are not yet clear. Moreover, the determinants of subcellular localization patterns of porphyrinic compounds are still uncertain. However, it is generally accepted that membranes are the primary targets of ...
If your condition does not improve within 3 months , or if it become worse, check with your doctor. Using Ameluz® with BF-RhodoLED® lamp may cause eye irritation or injury. It may also cause swelling of the eyelids. Tell your doctor right away if you have blurred vision, changes in vision, or red, sore eyes after receiving this medicine. After aminolevulinic acid application, avoid exposure to sunlight or bright indoor light (eg, from examination lamps, operating room lamps, tanning beds, or being close to lights) up until the time of the blue or red light treatment. Wide-brimmed hats or similar head covering can help protect you from sunlight or sources of light. Sunscreens will not protect you from sunlight or sources of light. Reduce your exposure to light if you experience stinging or burning on the treated areas before blue light treatment.. During the blue light treatment you will experience sensations of tingling, stinging, prickling or burning of the treated skin. These feelings of ...
Intro PDT is Photodynamic Therapy. It is a non-surgical procedure performed by one of our medical staff at Face Today Medi-Clinic. PDT involves simple
Photodynamic therapy has a lot to offer patients suffering from cancer of the oral cavity, but the complex anatomy and the difficulties created by scattered treatment light illuminating and potentially damaging sensitive normal tissue present significant technical challenges", said Thomas Foster, Ph.D., a professor of Imaging Sciences at URMC. Fosters lab has been working on various aspects of photodynamic therapy for more than 20 years.. Photodynamic therapy combines a class of drugs with light to selectively destroy cancer cells. The drug - called a photosensitizing agent - is injected into the patient and absorbed by the bodys cells. The drug tends to remain in cancer cells for a longer period of time. When exposed to a specific wavelength of light, often administered by a laser, the drugs produce a form of oxygen that kills nearby cells. This therapy is currently used to treat certain forms of oral cancer, in addition to other cancers. However, current oral cancer technologies have the ...
Photodynamic therapy (PDT) is a strategy for treating cancer, where a nontoxic prodrug, the photosensitizer (PS), is activated by light to form reactive species that destroy tumor tissue. The advantage of PDT over traditional chemotherapy is that drug toxicity can be localized to the target region through precise spatial and temporal control over the light delivery. In this way tumors are selectively destroyed while healthy tissue is spared, leading to superior patient outcomes. Furthermore, we have good evidence that our compounds elicit an immune response, leading to the suppression of metastases.. While PDT has shown remarkable efficacy against certain cancers, its widespread adoption has been limited by relatively few PSs having been approved as clinical agents. The lack of attention to the importance of the light dose protocol has also restricted progress; PSs have usually been developed in isolation from their end use, and the one-PS-for-all-applications approach has not produced results. ...
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Photodynamic therapy - Uses a laser combined with a light sensitive drug to destroy cancer cells. Learn about costs, procedure and recovery.
Compounds of formula (1) or formula (2): ##STR1## wherein M is a non-paramagnetic metal selected from Mg+2, Sn+2, and Zn+2, or represents 2 H30 each H+ bonded to one of the N atoms connected by the solid lines; R1 is a saturated of unsaturated hydrocarbyl residue of 8-25 C.; each R2 is independently selected from the group consisting of vinyl, ethyl, acetyl and 1-hydroxyethyl, and X is COOR3, wherein R3 is alkyl (1-C); are useful in photodynamic therapy and diagnosis. These compounds photosensitize target biological substrates to irradiation, and treating said substrates with these sensitizers followed by irradiation leads to the impairment or destruction of the biological substrate. When administered systemically, these compounds accumulate in the undesired target biological substrate. The compounds can also be utilized in vitro, for example to destroy infectious cells or viruses in blood intended for transfusion.
Simulations show how to maximize reaction rates for singlet oxygen generation. In brief: Reaction rates for 1O2 generation were computed with the DtC model. Rates were determined as a function of the geometry of the PS-O2 complex, spanning 15 different conformations. The rates mapped in this way change over five orders of magnitude between the largest and the…