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1EJ7: The transition between the open and closed states of rubisco is triggered by the inter-phosphate distance of the bound bisphosphate.
SWISS-MODEL Template Library (SMTL) entry for 2k9b.1. Structure and membrane interactions of the antibiotic peptide dermadistinctin K by multidimensional solution and oriented 15N and 31P solid-state NMR spectroscopy
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Heimburg, T.; Hildebrandt, P.; Marsh, D.: Cytochrome c-lipid interactions studied by resonance Raman and 31P NMR spectroscopy. Correlation between the conformational changes of the protein and the lipid bilayer. Biochemistry 30 (37), S. 9084 - 9089 (1991 ...
PURPOSE: Phosphorus magnetic resonance spectroscopy ((31)P-MRS) affords unique insight into cardiac energetics but has a low intrinsic signal-to-noise ratio (SNR) in humans. Theory predicts an increased (31)P-MRS SNR at 7T, offering exciting possibilities to better investigate cardiac metabolism. We therefore compare the performance of human cardiac (31)P-MRS at 7T to 3T, and measure T1s for (31)P metabolites at 7T. METHODS: Matched (31)P-MRS data were acquired at 3T and 7T, on nine normal volunteers. A novel Look-Locker CSI acquisition and fitting approach was used to measure T1s on six normal volunteers. RESULTS: T1s in the heart at 7T were: phosphocreatine (PCr) 3.05 ± 0.41s, γ-ATP 1.82 ± 0.09s, α-ATP 1.39 ± 0.09s, β-ATP 1.02 ± 0.17s and 2,3-DPG (2,3-diphosphoglycerate) 3.05 ± 0.41s (N = 6). In the field comparison (N = 9), PCr SNR increased 2.8× at 7T relative to 3T, the Cramer-Ráo uncertainty (CRLB) in PCr concentration decreased 2.4×, the mean CRLB in PCr/ATP decreased 2.7× and the PCr
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Our Bulletin 836P Solid-State Pressure Sensors measure liquids or gases from -14.5...10,000 psi. These sensors are available in display and non-display models with IO-Link Technology, discrete, and analog outputs. There are various process connections that include flush mount and sanitary connections for application flexibility.. ...
31P nuclear magnetic resonance (NMR) can provide information on the composition of phospholipid (PL) membranes, lipid headgroup orientation relative to the bilayers normal, and the phase state of PL systems. Interaction of the membrane with ions, drugs, other small molecules and peptides may lead to lipid phase change and lamellar phase disturbances, which can also be revealed in 31P NMR spectra. Traditional 31P NMR spectroscopy has been used for years, mainly to study lipid phase state. In the last few years, however, its utility has been extended by a number of solid-state methods in field-cycling spectroscopy. Membrane mimicking systems have been complemented with bicelles, which are more convenient for studying peptide structure in lipid-peptide interactions. Another challenge is the study of ordered membrane domains (rafts) induced in the presence of cholesterol or certain proteins. As a result, recent work has refined the structure of PL headgroups and elucidated membrane responses to ...
PHOSPHORUS-32 | H3P | CID 26751 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
|p|Mr Stephen Wild has been a Consultant in Obstetrics and Gynaecology for 8 years. He was born and bred in Harrogate and Harrogate remains his place of residence.|br /| |p|Mr Wild has trained in seve...
BACKGROUND: In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) provides biochemical information about phosphorus metabolism. AIM: To assess 31P MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models. PATIENTS AND METHODS: Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo 31P MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data. RESULTS: The PME/NTP, Pi/NTP, PME/PDE, and PME/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE/NTP and PDE/SHR were significantly lower in PBC patients compared with healthy volunteers (p , ...
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Phosphorus-32 Radionuclide Orthophosphoric acid in 1ml 0.02M HCl Shipped ambient. O-PHOSPHORIC ACID IN 0.02M HCI 8500-9120Ci(314-337TBq)/mmol ...
Phosphorus-32 Radionuclide Orthophosphoric acid in 1ml 0.02M HCl Shipped ambient. O-PHOSPHORIC ACID IN 0.02M HCI 8500-9120Ci(314-337TBq)/mmol ...
TY - JOUR. T1 - In vivo 31 P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. AU - Arias-Mendoza, F.. AU - Payne, G. S.. AU - Zakian, K. L.. AU - Schwarz, A. J.. AU - Stubbs, M.. AU - Stoyanova, R.. AU - Ballon, D.. AU - Howe, F. A.. AU - Koutcher, J. A.. AU - Leach, M. O.. AU - Griffiths, J. R.. AU - Heerschap, A.. AU - Glickson, J. D.. AU - Nelson, S. J.. AU - Evelhoch, J. L.. AU - Charles, H. C.. AU - Brown, T. R.. AU - Cruz-Lobo, J.. AU - Murphy-Boesch, J.. AU - Negendank, W. G.. AU - Shukla-Dave, A.. AU - Oregioni, A.. AU - Collins, D. J.. AU - Maisey, N. R.. AU - Ronen, Sabrina. AU - Doyle, Victoria L.. AU - Rijpkema, Mark. AU - Poptani, H.. AU - Lenkinski, R. E.. AU - Vigneron, D. B.. AU - Hu, Jiani. PY - 2006/6. Y1 - 2006/6. N2 - The standardization and reproducibility of techniques required to acquire anatomically localized 31p MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 Tare ...
Intracellular and extracellular spaces and the direct quantification of molar intracellular concentrations of phosphorus metabolites in the isolated rat heart using 31P NMR spectroscopy and phosphonate markers
Methods for determining the presence of a target polynucleotide sequence using chemical hybridization in sequential probe and displacement complex formation with potential for signal gain prior to detection are disclosed.
Pinheiro, T. J. T.; Vaz, W.L.C.; Geraldes, C. F. G. C.; Prado, A.; Dacosta, M. S.: A 31P-NMR study on multilamellar liposomes formed from the lipids of a thermophilic bacterium. Biochemical and Biophysical Research Communications 148 (1), S. 397 - 402 (1987 ...
|p|Mr Varadaraj has had excellent training and over 20 years of General Surgical, Urological experience and has performed complex surgeries along with managing emergency & routine Urology patients...
TY - JOUR. T1 - Metabolic Characterization of Human Non-Hodgkins Lymphomas in Vivo with the Use of Proton-decoupled Phosphorus Magnetic Resonance Spectroscopy. AU - Negendank, William G.. AU - Padavic-Shaller, Kristin A.. AU - Li, Chun Wei. AU - Murphy-Boesch, Joseph. AU - Stoyanova, Radka. AU - Krigel, Robert L.. AU - Schilder, Russell J.. AU - Smith, Mitchell R.. AU - Brown, Truman R.. PY - 1995/8/1. Y1 - 1995/8/1. N2 - Development of biological and clinical uses of in vivo 31P magnetic resonance spectroscopy has been hampered by poor anatomic localization of spectra and poor resolution of overlapping signals within phosphomonoester and phosphodiester regions of the spectrum. We applied 1H decoupling and nuclear Overhauser enhancement to improve resolution of 31P magnetic resonance spectra accurately localized to 21 non-Hodgkins lymphomas (NHL) by using three-dimensional chemical shift imaging. All 21 spectra had large phosphomonoester signals (26% of total phosphorus) that contained high ...
31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.: 31P-NMR measurements of the concentrations of phosphorus-containing metabolite
The ability of brain cells to regulate intracellular pH (pHi) and several phosphate metabolites was evaluated during 1 h of hypercapnia (inspiratory CO2 fraction of 0.10 and 0.05) in anesthetized rats by 31P high-field (145.6 MHz) nuclear magnetic re
The invention provides methods of suppression, prevention, and/or treatment of infection by viruses. A polynucleotide comprising an immunostimulatory sequence (an ISS) is administered to an individual who is at risk of being exposed to, has been exposed to or is infected with a virus. The ISS-containing polynucleotide is administered without any antigens of the virus. Administration of the ISS-containing polynucleotide results in reduced incidence and/or severity of one or more symptoms of virus infection.
We hypothesized that unexplained increases in nucleoside triphosphates (NTP) observed by 31P magnetic resonance spectroscopy (MRS) after treatment of tumours by DNA-damaging agents were related to chemotherapy-induced ...
DNA - Deoxyribonucleic Acid and RNA - Ribonucleic Acid: Biology Assignment Help, Homework Help, Project Help and Instant solution for DNA-RNA with qualified biology experts.
Mathieu Nedelec, Gregory Dupont. The influence of playing position in soccer on the recovery kinetics of cognitive and physical performance. The Journal of Sports Medicine and Physical Fitness, 2019, 59 (11), ⟨10.23736/S0022-4707.19.09433-7⟩. ⟨hal-02534538⟩ ...
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B. Rajagopalan, W.J. McKenna, M.J. Blackledge, G.K. Radda; Measurement of Phosphorus Metabolism in Hypertrophic Cardiomyopathy by 31P Magnetic Resonance Spectroscopy. Clin Sci (Lond) 1 January 1988; 74 (s18): 9P. doi: https://doi.org/10.1042/cs074009P. Download citation file:. ...
TY - JOUR. T1 - A perfusion system developed for 31p NMR study of melanoma cells at tissue‐like density. AU - Minichiello, Margaret M.. AU - Albert, Daniel M.. AU - Kolodny, Nancy H.. AU - Lee, Moon‐Soo ‐S. AU - Craft, Joseph L.. PY - 1989/4. Y1 - 1989/4. N2 - A perfusion culture system has been developed for 31P NMR study of human uveal melanoma metabolism by adapting the Vitafiber I cartridge system (Amicon). 31P NMR spectra collected weekly during periods of up to 10 weeks demonstrated increasing levels of phosphorus metabolites as the anchorage‐dependent cells grew to tissue‐like density. © 1989 Academic Press, Inc.. AB - A perfusion culture system has been developed for 31P NMR study of human uveal melanoma metabolism by adapting the Vitafiber I cartridge system (Amicon). 31P NMR spectra collected weekly during periods of up to 10 weeks demonstrated increasing levels of phosphorus metabolites as the anchorage‐dependent cells grew to tissue‐like density. © 1989 Academic ...
TY - JOUR. T1 - T1 values of phosphomonoester and phosphocreatine of brain show no significant change during development. AU - Hida, K.. AU - Kwee, Ingrid. AU - Nakada, T.. PY - 1992. Y1 - 1992. N2 - Changes in apparent 31P spin-lattice relaxation times (T1) associated with brain development were investigated in rat pups. While analysis of variance showed strong age dependency in [PME]/[ATP] and [PCr]/[ATP], the T1 values of PME, PCr, and ATP did not show any age dependency. The studies indicate that in contrast to the data which indicated aging-related changes in the T1 values of PME, the observed changes in PME during neonatal development are likely to be quantitative in nature.. AB - Changes in apparent 31P spin-lattice relaxation times (T1) associated with brain development were investigated in rat pups. While analysis of variance showed strong age dependency in [PME]/[ATP] and [PCr]/[ATP], the T1 values of PME, PCr, and ATP did not show any age dependency. The studies indicate that in ...
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Biomolecular nuclear magnetic resonance (NMR) spectroscopy allows the characterisation of structural and dynamic properties of ribonucleic acids (RNAs) in solution
GERALD FINK, RICHARD BRIMACOMBE; Synthesis and Applications of a Two-Step Reagent Forming Cross-links between Ribonucleic Acid and Protein. Biochem Soc Trans 1 December 1975; 3 (6): 1014-1015. doi: https://doi.org/10.1042/bst0031014. Download citation file:. ...
Background Phosphorus is the second most abundant inorganic element in the body and is a part of many important compounds, including deoxyribonucleic acid (DNA), ribonucleic acid (RNA),
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METHODS AND ARRAYS FOR DNA SEQUENCING - A method of sequencing a first polynucleotide strand having a first polynucleotide sequence, the first polynucleotide strand resembling a second polynucleotide strand having a known second polynucleotide sequence, the method employing a data set which, for one or more fragment(s) of the second polynucleotide sequence, contains: for each position along each said fragment: (i) first probe data describing the hybridization intensity of the first polynucleotide strand with a respective first probe designed to bind to a portion of the second polynucleotide strand centered at said position; and (ii) second probe data describing the respective hybridization intensities of the first polynucleotide strand with each of a set of second probes, each said second probe being designed to bind with a respective mutation of the corresponding portion of the second polynucleotide sequence which is formed by mutating the corresponding portion of the second polynucleotide ...
PS(18:0/20:4(8Z,11Z,14Z,17Z)) is a phosphatidylserine (PS or GPSer). It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoserines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PS(18:0/20:4(8Z,11Z,14Z,17Z)), in particular, consists of one chain of stearic acid at the C-1 position and one chain of eicsoatetraenoic acid at the C-2 position. The stearic acid moiety is derived from animal fats, coco butter and sesame oil, while the eicsoatetraenoic acid moiety is derived from fish oils. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. It is usually less than 10% of the total phospholipids, the greatest concentration being in myelin from brain tissue. However, it may comprise 10 to 20 ...
Perspective: Machines for RNAi. Life beyond cleavage: The case of Ago2 and hematopoiesis. RISC is a 5 phosphomonoester-producing RNA endonuclease
Lovely place and people. Very nicely designed rooms, but some details need a bit of attention. Good place after a long drive. Some great singing by the staff too ...
Everyone* knows that DNA codes for proteins. In between the DNA and the protein though, there is an intermediate molecule called RNA - ribonucleic acid (DNA is deoxyribonucleic acid). RNA is similar to DNA in many respects - long chain of bases that we can consider letters, which form a code - but its less…
இரைபோ கருவமிலம் அல்லது ஆர்.என்.ஏ. (RNA - Ribonucleic acid) என்பது ஒரு கருவமிலம் ஆகும். இதனை இரைபோக் கருக்காடி, ஐங்கரிமவினியக் கருக்காடி, ஐவினியக் கருக்காடி, ஐங்கரிமவினியக் கருவமிலம், ஐவினியக் கருவமிலம் என்ற பெயர்கள் கொண்டும் அழைக்கலாம். இது அனைத்து உயிரினங்களுக்கும் தேவையான நான்கு பெரிய பிரிவுகளில் அடங்கும் பருமூலக்கூறுகளில் ஒன்றான கருவமிலங்களில் ஒன்றாகும். இவையும் டி.என்.ஏ யைப் ...
A multinuclear (1H, 13C, 31P and 195Pt) magnetic resonance spectroscopy study of mixed ligand platinum(II) complexes with new N,N-dialkyl-N-acyl(aroyl)thioureas as ...
Phosphorus-31 nuclear magnetic resonance spectroscopy can determine the status of high energy phosphates in vivo. However, its application to human cardiac studies requires precise spatial localization without significant contamination from other tissues. Using image-selected in-vivo spectroscopy (ISIS), a technique that allows three-dimensional localization of the volume of interest, 12 subjects were studied to determine the feasibility and reproducibility of phosphorus-31 spectroscopy of the human heart. Nuclear magnetic resonance imaging was performed using a commercial 1.5 tesla system to define the volume of interest.. Phosphorus-31 spectra were obtained from the septum and anteroapical region of the left ventricle in 10 studies. Relative peak heights and areas were determined for high energy phosphates. The mean phosphocreatine to adenosine triphosphate ratio was 1.33 ± 0.19 by height analysis and 1.23 ± 0.27 by area analysis. Duplicate measurements in four subjects showed a ...
Extracts of barley leaves infected with bromegrass mosaic virus (BrMV) incorporated radioactivity into RNA when incubated with [3H]UTP in the presence of actinomycin D (Semal & Kummert, 1970). The radioactive product thus obtained was partly resistant to pancreatic RNase in × 2:SSC (0.15 m-NaCl, 0.015 m-sodium citrate, pH 7.0:SSC) but was entirely hydrolysed by this enzyme in × 0.05:SSC (Semal, 1970). A sequential synthesis of double- and single-stranded RNA was obtained under certain experimental conditions (Semal & Kummert, 1971). The present results identify the radioactive product associated with duplex RNA as a segment of BrMV-RNA. Cell-free extracts of the second leaf of barley seedlings, whose first leaf had been inoculated 3 days earlier with BrMV, were used to prepare the crude virus-induced RNA polymerase fraction. This fraction was incubated for 3½ min. with tritiated UTP (1 to 2 c/mm - The Radiochemical Centre, Amersham, Buckinghamshire, England), 10-3 m-EDTA, 20 µg./ml. of
Compositions and Methods for Inhibiting Expression of the PCSK9 Gene - The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by PCSK9 gene expression and the expression of the PCSK9 gene using the pharmaceutical composition; ...
The present invention relates to a wide range of genetic analyses using the technique of nucleic acid hybridization. These genetic analyses include, for example, the diagnosis of infections by foreign microbes and the detection of specific genetic traits and abnormalities. More specifically, the present invention is related to the detection of the presence of a polynucleotide sequence of interest.
Detection of circulating ribonucleic acid (cRNA) from blood is an unmet need in clinical diagnostics. Here we describe methods that...
Although I am fully convinced of the truth of the views given in this volume, I by no means expect to convince experienced naturalists whose minds are stocked with a multitude of facts all viewed, during a long course of years, from a point of view directly opposite to mine. It is so easy to hide our ignorance under such expressions as plan of creation, unity of design, etc., and to think that we give an explanation when we only restate a fact. Any one whose disposition leads him to attach more weight to unexplained difficulties than to the explanation of a certain number of facts will certainly reject the theory. ...