TY - JOUR. T1 - Metabolic Characterization of Human Non-Hodgkins Lymphomas in Vivo with the Use of Proton-decoupled
Phosphorus Magnetic Resonance Spectroscopy. AU - Negendank, William G.. AU - Padavic-Shaller, Kristin A.. AU - Li, Chun Wei. AU - Murphy-Boesch, Joseph. AU - Stoyanova, Radka. AU - Krigel, Robert L.. AU - Schilder, Russell J.. AU - Smith, Mitchell R.. AU - Brown, Truman R.. PY - 1995/8/1. Y1 - 1995/8/1. N2 - Development of biological and clinical uses of in vivo 31P
magnetic resonance spectroscopy has been hampered by poor anatomic localization of spectra and poor resolution of overlapping signals within phosphomonoester and phosphodiester regions of the spectrum. We applied 1H decoupling and nuclear Overhauser enhancement to improve resolution of 31P magnetic resonance spectra accurately localized to 21 non-Hodgkins lymphomas (NHL) by using three-dimensional chemical shift imaging. All 21 spectra had large phosphomonoester signals (26% of total
phosphorus) that contained high ...