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The activity of the early signaling enzyme, phospholipase Cβ1b (PLCβ1b), is elevated in diseased myocardium and activity increases with disease progression. PLCβ1b and the alternative splice variant, PLCβ1a, were expressed in mouse hearts using adeno-associated viral constructs (rAAV6-FLAG-PLCβ1b, rAAV6-FLAG- PLCβ1a) delivered intravenously. Functional responses were assessed in vivo and confirmatory mechanistic studies were conducted in neonatal rat ventricular myocytes (NRVM). FLAG-PLCβ1b was expressed in all of the chambers of the mouse heart, but was highest in left ventricle, where expression was observed in ,90% of the cells and was localized to the sarcolemma and T-tubules. Heightened PLCβ1b expression caused a rapid loss of contractility and down-regulation of Phospholamban expression. The loss of contractility induced by PLCβ1b was reversed by inhibition of protein kinase Cα (PKCα). PLCβ1a did not affect contractile function or phospholamban expression. Mechanistic analysis ...
We are interested in learning how small molecules in the blood stream can cause cells to react in specific ways, such as growing, dividing or migrating. While there are many agents that can stimulate or inhibit cell behavior, we are most interested in the ability of certain hormones and neurotransmitters to activate a family of proteins called "G Proteins". G proteins can simulate an enzyme called phospholipase Cbeta (PLCbeta). Activation of PLCbeta raises the level of calcium in the cell, which changes the activity of many other proteins. Additionally, PLCbeta can also affect the ability of a cell to control the transcription of specific genes into proteins by changing the stability of their messenger RNA. ...
Mouse Monoclonal Anti-PP2C beta/PPM1B Antibody (1A3-2A4) [PerCP]. Validated: WB, ELISA, ICC/IF, IP, PLA. Tested Reactivity: Human. 100% Guaranteed.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
In neurons and transformed cell lines, opioid receptors are coupled to various signaling mechanisms involved in Ca2+ mobilization, including inhibition or activation of Ca2+ channels and phospholipase C-beta (PLC-beta), the enzyme responsible for generation of the Ca2+ mobilizing messenger inositol-1,4,5-trisphosphate [Ins(1,4,5)P3]. In the current study, we used selective PLC-beta and G protein antibodies to identify the PLC-beta isozyme activated by opioid receptors in intestinal smooth muscle and the G proteins to which the PLC-beta isozyme and adenylyl cyclase are coupled. [D-Pen2,D-Pen5]Enkephalin, a delta receptor agonist, stimulated Ins(1,4,5)P3 formation, Ca2+ release, and contraction; inhibited forskolin-stimulated cAMP formation in dispersed muscle cells; and stimulated phosphoinositide hydrolysis in plasma membranes; all of the effects were blocked by pertussis toxin. [D-Pen2,D-Pen5]Enkephalin-stimulated Ins(1,4,5)P3 formation, Ca2+ release, and contraction in permeabilized muscle ...
With Microtiter Operant Gustometer, MOG, rats are trained to become expert taste testers; the work has the potential to improve the process for discovering new flavor ingredients and more.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
... , Authors: Matilde Y. Follo, Vincenza Rita Lo Vasco, Giovanni Martinelli, Giandomenico Palka, Lucio Cocco. Published in: Atlas Genet Cytogenet Oncol Haematol.
GenePORTER 2 Citations - Cell Line Cell Type Source Genlantis Product Citation 3T3-L1 Embryo Swiss Mouse GenePORTER 2 Transfection Reagent Sekimoto, H., Eipper-Mains, J., Pond-Tor, S. and Boney, C.M. (2005) αvβ3 Integrins and Pyk2 Mediate Insulin-Like Growth Factor I Activation of Src and Mitogen-Activated Protein Kinase in 3T3-L1 Cells. Mol. Endocrinol. 19: 1859 - 1867. A549 Lung Carcinoma Human GenePORTER 2 Transfection Reagent Alcorn, M.J., Booth, J.L., Coggeshall, K.M., Metcalf, J.P. (2001) Adenovirus Type 7 Induces Interleukin-8 Production via Activation of Extracellular Regulated Kinase 1/2. J.Virology 75: 6450-59. AD293 Embryonic Kidney Human GenePORTER 2 Transfection Reagent Zhong, M., Murtazina, D.A., Phillips, J., Ku, C-Y and Sanborn, B.M. (2008) Multiple Signals Regulate Phospholipase CBeta3 in Human Myometrial Cells. Biol Reprod. 78: 1007 - 1017 alpha-T3 Pituitary Mouse GenePORTER 2 Transfection Reagent Feng, J., Lawson, M.A. and Melamed, P. (2008) A
Perform reliable qPCR with Bio-Rads pre-validated PLCB4 primer pair, for the Human genome. Designed for SYBR Green-based detection.
Pennsylvania Liquor Control Board 2011 report on High-Risk and Underage Drinking in the state. by CommonwealthFnd in Types > Research > Literature
PLC activity is required for directional protrusion in response to an EGF source. (A) The response of a control (U73343) cell (top) and of a PLC-inhibited (U731
Gentaur molecular products has all kinds of products like :search , GenWay \ S-100 Protein beta chain (S100B) Human - S100 calcium-binding protein B. S-100 protein beta subunit. S-100 protein beta chain N_A \ 10-663-45599 for more molecular products just contact us
If you have used this database, please ensure that you acknowledge this most recent Pseudomonas Genome Database publication rather than just the website URL. Thank you!. Winsor GL, Griffiths EJ, Lo R, Dhillon BK, Shay JA, Brinkman FS (2016 ...
TY - JOUR. T1 - Cholinergic chemosensory cells in the trachea regulate breathing. AU - Krasteva, Gabriela. AU - Canning, Brendan J. AU - Hartmann, Petra. AU - Veres, Tibor Z.. AU - Papadakis, Tamara. AU - Mühlfeld, Christian. AU - Schliecker, Kirstin. AU - Tallini, Yvonne N.. AU - Braun, Armin. AU - Hackstein, Holger. AU - Baal, Nelli. AU - Weihe, Eberhard. AU - Schütz, Burkhard. AU - Kotlikoff, Michael. AU - Ibanez-Tallon, Ines. AU - Kummer, Wolfgang. PY - 2011/6/7. Y1 - 2011/6/7. N2 - In the epithelium of the lower airways, a cell type of unknown function has been termed "brush cell" because of a distinctive ultrastructural feature, an apical tuft of microvilli. Morphologically similar cells in the nose have been identified as solitary chemosensory cells responding to taste stimuli and triggering trigeminal reflexes. Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (α-gustducin, phospholipase Cβ2) of bitter ...
Genetic and pharmacological studies demonstrate that Endothelin1 (Edn1) is a key signaling molecule for patterning the facial skeleton in fish, chicks, and mice. When Edn1 function is reduced early in development the ventral lower jaw and supporting structures are reduced in size and often fused to their dorsal upper jaw counterparts. We show that schmerle (she) encodes a zebrafish ortholog of Phospholipase C, beta 3 (Plcbeta3) required in cranial neural crest cells for Edn1 regulation of pharyngeal arch patterning. Sequencing and co-segregation demonstrates that two independent she (plcbeta3) alleles have missense mutations in conserved residues within the catalytic domains of Plcbeta3. Homozygous plcbeta3 mutants are phenotypically similar to edn1 mutants and exhibit a strong arch expression defect in Edn1-dependent Distalless (Dlx) genes as well as expression defects in several Edn1-dependent intermediate and ventral arch domain transcription factors. plcbeta3 also genetically interacts with ...
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Growing evidence shows that sensory cells which enable us to taste sweetness, bitterness and savoriness (umami) are not limited to the tongue. These so-called Trpm5-expressing chemosensory cells are also found in the respiratory ...
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
최근 외부자극에 대한 생체 신호전달체계에서 중요한 효소로 알려진 phospholipase C(PLC) 동위효소(isozyme)들의 발현은 조직의 종류와 발달과정에 따라 특이한 양상을 보이며 PLC동위효소 중 PLC-γ1은 세포의 성장, 분화 및 증식에 중추적 요소로 알려져 있다. 또한 ras 암유전자단백도 세포의 성장을 유도하는 것으로 알려져 있어 방사선 조사 후 PLC 동위효소와 ras암유전단백이 관여하는지를 규명하고, 이러한 재생과정에 방사선감작약물로 널리 알려져 있는 5-fluorouracil(5-FU)투여방법이 미치는 영향을 보고자 본 연구를 계획하였다. 흰쥐를 실험동물로 하여 정상대조군(I), 방사선조사 단독군(II), 방사선과 5-FU 12시간 지속성 정주병행군(III), 방사선조사 단독군 (II), 방사선과 5-FU12시간 지속성 정주단독군 (V), 5FU 일시정주단독군 (VI)로 나누어 관찰하였다. 방사선은 흰쥐 ...
Publikations-Datenbank der Fraunhofer Wissenschaftler und Institute: Aufsätze, Studien, Forschungsberichte, Konferenzbeiträge, Tagungsbände, Patente und Gebrauchsmuster
Yadav S, Garner K, Georgiev P, Li M, Gomez-Espinosa E, Panda A, Mathre S, Okkenhaug H, Cockcroft S, Raghu P. 2015. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction.. J Cell Sci. 128(17):3330-44. ...
Yadav S, Garner K, Georgiev P, Li M, Gomez-Espinosa E, Panda A, Mathre S, Okkenhaug H, Cockcroft S, Raghu P. 2015. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction.. J Cell Sci. 128(17):3330-44. ...
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243. Studies in Calliphora by Paulsen Huber and colleagues have shown that INAD binds not only TRP but also PLC (NORPA) and PKC Maxтlon.
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The phototransduction cascade in Drosophila is a prototypical G-protein signaling pathway and many of its components have been well-studied. Early genetic screens identified many of the major proteins involved in this pathway and study over the past several decades has not only elucidated their function, but also contributed to our overall understanding of the visual signaling cascade. However, there are still several unanswered questions concerning the phototransduction process and many proteins that remain unidentified. In order to isolate previously unidentified proteins involved in Drosophila phototransduction, a genetic screen aimed at isolating suppressors of retinal degeneration was conducted. Two of the mutant lines from this screen were found to have interesting phenotypes that suggested that the defective proteins were affecting phototransduction. Characterization of the mutant phenotypes followed by identification of the defective genes revealed that the aberrant proteins are involved ...
Yamaguchi, T.; Yamashita, J.; Ohmoto, M.; Aoudé, I.; Ogura, T.; Luo, W.; Bachmanov, A. A.; Lin, W.; Matsumoto, I.; Hirota, J. (2014) Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillus cells in the mouse main olfactory epithelium. BMC Neuroscience, 15, 13.. Bachmanov, A.A.; Bosak, N.P.; Lin, C.; Matsumoto, I.; Ohmoto, M.; Reed, D.R.; Nelson, T.M. (2013) Genetics of taste receptors. Current Pharmaceutical Design, (Electronic citation) PMID: 23886383. Matsumoto, I.; Ohmoto, M.; Abe, K. (2013) Functional diversification of taste cells in vertebrates. Seminars in Cell & Developmental Biology, 24, 210-214.. Matsumoto, I.(2013) Gustatory neural pathways from taste receptor cells revealed by genetic tracing. Bioscience, Biotechnology, Biochemisty, 77, 1359-1362.. Ohmoto, M.; Yamaguchi, T.; Yamashita, J.; Bachmanov, A.A.; Hirota, J.; Matsumoto, I. (2013) Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity. ...
Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic autosomal recessive spondylometaphyseal dysplasia (SMD) in two Emirati first cousins. They displayed postnatal growth deficiency causing profound limb shortening with proximal and distal segments involvement, narrow chest, radiological abnormalities involving the spine, pelvis and metaphyses, corneal clouding and intellectual disability. Whole genome homozygosity mapping localised the genetic cause to 11q12.1-q13.1, a region spanning 19.32 Mb with ~490 genes. Using whole exome sequencing, we identified four novel homozygous variants within the shared block of homozygosity. Pathogenic variants in genes involved in phospholipid metabolism, such as PLCB4 and PCYT1A, are known to cause bone dysplasia with or without eye anomalies, which led us to select PLCB3 as a strong candidate. This gene encodes phospholipase C β 3, an enzyme that converts phosphatidylinositol 4,5 bisphosphate (PIP2) to ...
Methods In the present study, we report the clinical and molecular delineation of a new form of syndromic autosomal recessive spondylometaphyseal dysplasia (SMD) in two Emirati first cousins. They displayed postnatal growth deficiency causing profound limb shortening with proximal and distal segments involvement, narrow chest, radiological abnormalities involving the spine, pelvis and metaphyses, corneal clouding and intellectual disability. Whole genome homozygosity mapping localised the genetic cause to 11q12.1-q13.1, a region spanning 19.32 Mb with ~490 genes. Using whole exome sequencing, we identified four novel homozygous variants within the shared block of homozygosity. Pathogenic variants in genes involved in phospholipid metabolism, such as PLCB4 and PCYT1A, are known to cause bone dysplasia with or without eye anomalies, which led us to select PLCB3 as a strong candidate. This gene encodes phospholipase C β 3, an enzyme that converts phosphatidylinositol 4,5 bisphosphate (PIP2) to ...
Phospholipase C gamma: A phosphoinositide phospholipase C subtype that is primarily regulated by PROTEIN-TYROSINE KINASES. It is structurally related to PHOSPHOLIPASE C DELTA with the addition of SRC HOMOLOGY DOMAINS and pleckstrin homology domains located between two halves of the CATALYTIC DOMAIN.
The family of WD-repeat proteins comprises over 30 different proteins that share a highly conserved repeating motif [Neer, E. J., Schmidt, C. J., Nambudripad, R., & Smith, T. F. (1994) Nature 371, 297-300]. Members of this family include the signal-transducing G protein beta subunit, as well as other proteins that regulate signal transduction, transcription, pre-mRNA splicing, cytoskeletal organization, and vesicular fusion. The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all WD-repeat proteins form a similar structure. If so, it will be possible to use information about important surface regions of one family member to predict properties of another. If WD proteins form structures similar to G beta, their hydrodynamic properties should be those of compact, globular ...
If you have used this database, please ensure that you acknowledge this most recent Pseudomonas Genome Database publication rather than just the website URL. Thank you!. Winsor GL, Griffiths EJ, Lo R, Dhillon BK, Shay JA, Brinkman FS (2016 ...
Drosophila lazaro protein: gene lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction; has been sequenced
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Plasmid q4wt from Dr. Bruce Conklins lab contains the insert Gq alpha and is published in Nature. 1993 May 20. 363(6426):274-6. This plasmid is available through Addgene.