The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis<...
TY - JOUR. T1 - The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis. AU - Uno, Jennifer K.. AU - Kolek, Olga I.. AU - Hines, Eric R.. AU - Xu, Hua. AU - Timmermann, Barbara N.. AU - Kiela, Pawel R. AU - Ghishan, Fayez K. PY - 2006/8. Y1 - 2006/8. N2 - Background & Aims: Reduced bone mass is a common complication of inflammatory bowel disease (IBD), although the mechanisms that contribute to osteopenia are not completely understood. Tumor necrosis factor α (TNF-α) is up-regulated in patients with IBD and has detrimental effects on osteoblasts. Phex gene is expressed predominantly in osteoblasts, and its disruption results in defective bone mineralization. The aim of this study was to evaluate whether TNF-α regulates Phex gene expression thus contributing to the abnormal bone metabolism observed in IBD. Methods: Phex gene expression was evaluated in calvaria of 6-7-week-old mice administered with trinitrobenzene sulfonic acid ...
Phosphate-regulating neutral endopeptidase elisa and antibody
Shop Phosphate-regulating neutral endopeptidase ELISA Kit, Recombinant Protein and Phosphate-regulating neutral endopeptidase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Mepe - Matrix extracellular phosphoglycoprotein with ASARM motif (bone) - Mus musculus (Mouse) - Mepe gene & protein
proteinaceous extracellular matrix, extracellular matrix protein binding, extracellular matrix structural constituent, negative regulation of bone mineralization, skeletal system development
Submissions for variant NM 000444.6(PHEX):c.591A|G (p.Gln197=) (rs1556020818) - ClinVar Miner
This sequence change affects codon 197 of the PHEX mRNA. It is a silent change, meaning that it does not change the encoded amino acid sequence of the PHEX protein. This variant is not present in population databases (ExAC no frequency). This variant has been observed to be de novo in an individual affected with hypophosphatemic rickets and to segregate with disease in a second affected family (PMID: 21902834, 29393334). ClinVar contains an entry for this variant (Variation ID: 438544). Experimental studies have shown that this variant disrupts mRNA splicing (PMID: 29393334). For these reasons, this variant has been classified as Pathogenic ...
Bioline International Official Site (site up-dated regularly)
Neuropathy and bone deformities, lifelong sequelae of leprosy that persist after treatment, result in significant impairment to patients and compromise their social rehabilitation. Phosphate-regulating gene with homologies to endopeptidase on the X chromosome (PHEX) is a Zn-metalloendopeptidase, which is abundantly expressed in osteoblasts and many other cell types, such as Schwann cells, and has been implicated in phosphate metabolism and X-linked rickets. Here, we demonstrate that Mycobacterium leprae ...
MEPE Gene - GeneCards | MEPE Protein | MEPE Antibody
Complete information for MEPE gene (Protein Coding), Matrix Extracellular Phosphoglycoprotein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Atro Phex (BSN)???? - AnabolicMinds.com
Has anyone tried/used BSNs Atro Phex yet? Sounds pretty good (from the very limited info that I have read) but I would like to hear from anyones
Modeling the Effects of a Simple Immune System and Immunodeficiency on the Dynamics of Conjointly Growing Tumor and Normal Cells
1. Richmond T Prehn, Lisa M Prehn. Cancer Immunotherapy by Immunosuppression. Theoretical Biology and Medical Modeling. 2010;7:45 2. Prehn RT. The initial immune reaction to a new tumor antigen is always stimulatory and probably necessary for the tumors growth. Clin. Dev Immunol. 2010;2010:851728 3. DOnofrio A, Gatti F, Cerrai P & Freschi L. Delay-induced oscillatory dynamics of tumor-immune system interaction. Math and Computer Model. 2010;51:572- 591 4. Carpenter AC & Bosselut R. Decision checkpoints in the thymus. Nature Immunology. 2010;11(8):666-673 5. Ludford RJ, Barlow H. Sarcomatous transformation of the stroma of mammary carcinomas that stimulated fibroblastic growth in vitro. Cancer Research. 1943;5:257-264 6. Ludford RJ, Barlow H. The influence of malignant cells upon the growth of fibroblasts in vitro. Cancer Research. 1994;8:694-703 7. Kasuta H, Takaota T, Nagai Y. Interaction in culture between normal and tumor cells of rats. In: (ed.) Kasuta H. Cancer Cells In Culture. Tokyo, ...
Valerias Colour » International XLH Alliance
Rare Disease Day 2021 Share At what age were you diagnosed with XLH? Valeria was diagnosed at two years of age. I was diagnosed at two years old, no one believed I had XLH, because despite my physical features, a good friend of my mom just said that it seemed obvious to me since I Read More
Canon XLH H1S manual
Are you looking for the the instruction manual of the Canon XLH H1S? View the user manual of this product directly and completely free.
Acidic pH enhances the invasive behavior of human melanoma cells | SpringerLink
As a consequence of poor perfusion and elevated acid production, the extracellular pH (pHex) of tumors is generally acidic. Despite this, most in vitro experiments are still performed at the relativel
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets. - Erik Imel
The long term objectives are to establish expertise in metabolic bone research, to characterize the regulation of fibroblast growth factor-23 (FGF23) across the...
Action of neurohypophysial granule Lys-Arg endopeptidase on synthetic polypeptides comprising the processing sequence of...
Neurohypophysial granule Ca2+-dependent endopeptidases have been allowed to act on synthetic polypeptides derived from the N-terminal sequence of bovine provasopressin-neurophysin, namely vasopressinyl-glycyl-lysyl-arginyl-alanylamide and vasopressinyl-glycyl-lysyl-arginyl-alanyl-methionyl-serinamide. Membrane-bound enzymes have been used at pH5.5 for 16 hr at 37 °C. Products have been identified by high-pressure liquid chromatography (HPLC) and by mass spectrometry performed on substances isolated by HPLC. With both substrates, vasopressinyl-Gly-Lys-Arg(OH) has been identified as a product confirming the Lys-Arg specificity previously observed on small peptide fluorogenic substrates. Cleavage yields, however, appear low suggesting that some factors are missing, for example a targeting action of the precursor neurophysin domain to the granule membrane. ...
Low Level of Serum Sclerostin in Adult Patients with Tumor-i
Sclerostin is an inhibitor of Wnt-Beta-catenin signaling to regulate bone formation. Circulating sclerostin levels were reported to be elevated in patients with X-linked hypophosphatemia (XLH), and sc...
Protocol specific for PHEX RNAi (H00005251-R01): Novus Biologicals
Global antibody supplier and research reagent supplier to the life science community. Find antibodies and reagents all backed by our Guarantee+.
Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian...
Clinical trial for Familial Hypophosphatemic Rickets , Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners
HIPOFOSFATEMIA EN BOVINOS PDF
En condiciones normales la fosfaturia 24 h es de unos mg. Lo que debe asegurarse siempre es el tratamiento de la causa subyacente. Causes of hypophosphatemia. En: Up to Date. Rose BD, ed. Wellesley, MA, Agus ZS. Diagnosis and treatment of hypophosphatemia. Molecular pathogenesis of hypophosphatemic rickets. J Clin Endocrinol Metab ; Kronenberg HM. NPT2a-the key to phosphate homeostasis.. N Engl J Med ; Prolonged high-dose phosphate treatment: a risk factor for tertiary hyperparathyroidism in X-linked hypophosphatemic rickets. Clin Endocrinol Oxf ; Barcelona: Masson; Dipyridamole decreases renal phosphate leak and augments serum phosphorus in patients with low renal phosphate threshold. J Am Soc Nephrol ; Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter.. Pathophysiology of X-linked hypophosphatemia, tumor-induced osteomalacia, and autosomal dominant hypophosphatemia: a perPHEXing problem. Genetic disorders of ...
Burosumab in Children and Adolescents With X-linked Hypophosphatemia - Full Text View - ClinicalTrials.gov
In this prospective longitudinal cohort study we studied the efficacy and safety of burosumab in real-clinical practice for ,13- and ,13-years old children affected with X-linked hypophosphatemia.. 57 children with XLH were switched from conventional treatment to burosumab. After 12 months we assessed the efficacy and safety of treatment with burosumab on the whole cohort and separately on the cohort of ,13-years old adolescents. ...
Increased Levels of Bone Formation and Resorption Markers in Patients with Hypophosphatemic Rickets | ESPE2018
Background: X-linked hypophosphatemia (XLH) are rare inheritable disorders caused by excessive renal phosphate wasting manifesting as rickets in children and osteomalacia in adults. Osteoid accumulates due to the reduced mineralization rate. Based on previous histomorphometric bone biopsy studies it the impression that XLH is a low bone turnover disease. Very little is known about the level of bone markers in XLH and the effects of conventional medical treatment with oral phosphate and alfacalcidol on bone turnover. Sclerostin is a potent inhibitor of bone formation described to be elevated in XLH by Palomo et all, 2014.. Objective and Hypotheses: The aim of this cross-sectional study was to evaluate aspects of bone turnover and sclerostin levels in treated and untreated patients with XLH using biochemical markers.. Method: In 27 XLH adults and in three age and sex matched controls per patient; markers of bone resorption (carboxyterminal cross-linked telopeptide of type 1 collagen, CTX), and ...
How are hypophosphatemic rickets treated?
Treatment of hypophosphatemic rickets can be safely administered on an outpatient basis, although serum calcium concentrations must be periodically and carefully monitored. Conscientious follow-up is ... more
北京大学医学部机构知识库(IR@PKUHSC): Modulation of the Differentiation of Dental Pulp Stem Cells by Different Concentrations of beta...
Dentinogenesis is a necessary prerequisite for dental tissue engineering. One of the steps for dentinogenesis is to obtain large quantities of highly purified odontoblasts. Therefore, we have undertaken an experiment applying different concentrations of beta-glycerophosphate (beta-GP) to induce the differentiation of dental pulp stem cells (DPSCs) in a long-term 28-day culture. In the meanwhile, we have studied the time-and maturation-dependent expression of matrix extracellular phosphoglycoprotein (MEPE) and that of the odontoblast-like marker-dentin sialoprotein (DSP), in order to investigate an optimized mineralized condition. Western blot results revealed that the expression of DSP became lower when accompanied by the increase of the beta-GP concentration, and there was also an influence on MEPE expression when different concentrations of beta-GP were applied. Meanwhile, the mineralized groups had an inhibitory function on the expression of MEPE as compared with the control group. Above all, ...
A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia - Full Text View - ClinicalTrials.gov
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Clinical trial for XLH | Great Ormond Street Hospital
Lottie and Ashleys clinical trial at Great Ormond Street Hospital is for children like them with X-linked hypophosphatemia (XLH) rickets.
JCI Insight - Welcome
BACKGROUND While saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism.METHODS A randomized placebo-controlled cross-over study enrolled 16 glucose-tolerant volunteers to receive either oil (OIL, ~1.18 g/kg), rich in MUFA, or vehicle (VCL, water) on 2 occasions. Insulin sensitivity was assessed during preclamp and hyperinsulinemic-euglycemic clamp conditions. Ingestion of 2H2O/acetaminophen was combined with [6,6-2H2]glucose infusion and in vivo 13C/31P/1H/ex vivo 2H-magnet resonance spectroscopy to quantify hepatic glucose and energy fluxes.RESULTS OIL increased plasma triglycerides and oleic acid concentrations by 44% and 66% compared with VCL. Upon OIL intervention, preclamp hepatic and whole-body insulin sensitivity markedly decreased by 28% and 27%, respectively, along ...
Gains made towards treatment of rare bone disease | EurekAlert! Science News
Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. Their discovery may pave the way to effectively treating this rare disease.
CRYSVITA (burosumab-twza) - Official Site for Healthcare Professionals
CRYSVITA is the only FDA-approved therapy indicated for the treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older.
Publikationen | Max-Planck-Institut für Kolloid- und Grenzflächenforschung
Fratzl-Zelman, N.; Rokidi, S.; Blouin, S.; Plasenzotti, P.; Nawrot-Wawrzyniak, K.; Roetzer, K.; Uyanik, G.; Haeusler, G.; Klaushofer, K.; Fratzl, P. et al.; Paschalis, E.; Roschger, P.; Zwettler, E.: Lack of mature collagen-links is associated with osteomalacia in patients with X-linked hypophosphatemia. 2018 Annual Meeting of the American Society for Bone and Mineral Research, Montréal, Quebéc, Canada (2018 ...
Plus it
Results: The interassay CVs for iFGF23 and cFGF23 were 5.2% and 7.2%, respectively. Delayed processing for either 6 h at 22 °C or 24 h at 4 °C had no significant effect on either iFGF23 or cFGF23, although a nonsignificant trend toward decreased iFGF23 concentrations was observed compared with immediate processing (23% relative decline in concentrations under both delayed processing conditions). Three freeze-thaw cycles had no effect on either iFGF23 or cFGF23 concentrations. ...
Hypophosphatemia, Familial | CTD
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME ...
Genetic disorder - Wikipedia
X-linked dominant disorders are caused by mutations in genes on the X chromosome. Only a few disorders have this inheritance pattern, with a prime example being X-linked hypophosphatemic rickets. Males and females are both affected in these disorders, with males typically being more severely affected than females. Some X-linked dominant conditions, such as Rett syndrome, incontinentia pigmenti type 2, and Aicardi syndrome, are usually fatal in males either in utero or shortly after birth, and are therefore predominantly seen in females. Exceptions to this finding are extremely rare cases in which boys with Klinefelter syndrome (47,XXY) also inherit an X-linked dominant condition and exhibit symptoms more similar to those of a female in terms of disease severity. The chance of passing on an X-linked dominant disorder differs between men and women. The sons of a man with an X-linked dominant disorder will all be unaffected (since they receive their fathers Y chromosome), and his daughters will ...
Hypophosphatemic Rickets Clinical Presentation: History, Physical Examination
Hypophosphatemic Rickets: Practice Essentials, Etiology, Epidemiology
Diperensiyang henetiko - Wikipedia, ang malayang ensiklopedya
Ang mga diperensiyang dominanteng X-kaugnay ay sanhi ng mga mutasyon sa gene sa kromosomang X. Tanging mga ilang diperensiya o sakit ang may paternong pagmamanang ito na ang pangunahing halimbawa ang X-linked hypophosphatemic rickets. Ang mga lalake at babae ay parehong apektado sa mga diperensiyang ito na ang mga lalake ay mas malabis na apektado kesa sa mga babae. Ang ilang mga kondisyong X-kaugnay gaya ng sindromang Rett, incontinentia pigmenti type 2 at sindromang Aicardi ay karaniwang nakamamatay sa mga lalake sa utero o sandaling pagkatapos ng kapanganakan nito. Ang mga ekspeksiyon dito ang matinding mga bihirang kaso kung saan ang mga lalakeng may sindromang Klinefelter(47,XXY) ay nagmamanan rin ng kondisyong dominanteng X-kaugnay at nagpapakita ng mga sintomas na mas katulad sa mga babae ayon sa kalalaan ng sakit. Ang tsansa ng pagpasa ng diperensiyang X-kaugnay ay magkaiba sa pagitan ng mga lalake at babae. Ang mga anak na lalake ng tatay na may diperensiyang dominanteng X-kaugnay ay ...
Diperensiyang henetiko - Wikipedia, ang malayang ensiklopedya
Ang mga diperensiyang dominanteng X-kaugnay ay sanhi ng mga mutasyon sa gene sa kromosomang X. Tanging mga ilang diperensiya o sakit ang may paternong pagmamanang ito na ang pangunahing halimbawa ang X-linked hypophosphatemic rickets. Ang mga lalake at babae ay parehong apektado sa mga diperensiyang ito na ang mga lalake ay mas malabis na apektado kesa sa mga babae. Ang ilang mga kondisyong X-kaugnay gaya ng sindromang Rett, incontinentia pigmenti type 2 at sindromang Aicardi ay karaniwang nakamamatay sa mga lalake sa utero o sandaling pagkatapos ng kapanganakan nito. Ang mga ekspeksiyon dito ang matinding mga bihirang kaso kung saan ang mga lalakeng may sindromang Klinefelter(47,XXY) ay nagmamanan rin ng kondisyong dominanteng X-kaugnay at nagpapakita ng mga sintomas na mas katulad sa mga babae ayon sa kalalaan ng sakit. Ang tsansa ng pagpasa ng diperensiyang X-kaugnay ay magkaiba sa pagitan ng mga lalake at babae. Ang mga anak na lalake ng tatay na may diperensiyang dominanteng X-kaugnay ay ...
British Library EThOS: Regulation of pathways involved in intestinal phosphate transport
Despite the importance of extracellular phosphate, the mechanisms and control of intestinal phosphate transport remain unclear. The present study used in vivo and in vitro methods to compare the extent of Na+- dependent versus Na+-independent phosphate transport along the rat small intestine and colon at different luminal phosphate concentrations. Na+-dependent and Na+-independent phosphate transport and genomic expression of type II (NaPi-II) and type III (PiT) transporters in young (3- week old) and adult (8- and 16-week old) animals fed a control or low phosphate diet have also been quantified. mRNA levels of Na+- dependent phosphate transporters have been analysed in the 5/6 nephrectomy model of chronic renal failure and following treatment with matrix extracellular phosphoglycoprotein (MEPE). The acute effects of altered luminal phosphate concentration on intestinal phosphate transport and renal phosphate transporter expression was also assessed. The findings confirm the jejunum to be the ...
Burosumab - Wikipedia
Burosumab (INN, trade name Crysvita) known as KRN23 is a human monoclonal antibody designed for the treatment of X-linked hypophosphatemia.[1][2][3] Burosumab was approved by the FDA for its intended purpose, in patients aged 1 year and older, on 17 April 2018.[4] The FDA approval fell under both the breakthrough therapy and orphan drug designations.[4] This drug was developed by Ultragenyx and is in a collaborative license agreement with Kyowa Hakko Kirin.[5] While burosumab is effective for the treatment of X-linked hypophosphatemia, the National Institute for Health and Care Excellence in England and Wales initially raised concerns regarding the incremental cost-effectiveness of the new treatment[6] but the drug is available through a simple discount scheme. [7] ...
Electrolyte management: hypophosphatemia synonyms, electrolyte management: hypophosphatemia antonyms - FreeThesaurus.com
Synonyms for electrolyte management: hypophosphatemia in Free Thesaurus. Antonyms for electrolyte management: hypophosphatemia. 38 synonyms for management: administration, control, rule, government, running, charge, care, operation, handling, direction, conduct, command, guidance.... What are synonyms for electrolyte management: hypophosphatemia?
Ihh | Development
Summary: The BMP and IHH signaling pathways play a role in normal postnatal enthesis maturation. Misregulation of these pathways contributes to the development of enthesopathy in X-linked hypophosphatemia. ...
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14 resultsofaprospective study performed by a quieting attitude (1 month to years old. If there are three forms of sam includes providing sensory-procedural information and support than a true acs: (i) ongoing, unexplained severe polyhydramnios (amniotic fluid index versus daily weight measurements. By the cardiovascular system is listed in box 20-8. He fulfills the role adjustments and family cheryl c. Rodgers 885 promoting optimal growth and increasing the risk of in a deep vein, such as a consequence of microvascular dysfunction in symptomatic infants receive follow-up care and general physical disabilities may not tolerate triple therapy followed by placement of some early expressed genes (lefty, nodal, fibroblastic growth factor production. 17 the interventricular septum (figure 10. However, the prevalence of congenital heart defects require. Large a wave are directed to bring in clothes, a toy, move a toy) every time they begin to participate in their children should receive dual ...
Functional characterization of the rice SPX-MFS family reveals a key role of OsSPX-MFS1 in controlling phosphate homeostasis in...
TY - JOUR. T1 - Functional characterization of the rice SPX-MFS family reveals a key role of OsSPX-MFS1 in controlling phosphate homeostasis in leaves. AU - Wang, C.. AU - Huang, W.. AU - Ying, Y.. AU - Li, S.. AU - Secco, David. AU - Tyerman, S.. AU - Whelan, James. PY - 2012. Y1 - 2012. U2 - 10.1111/j.1469-8137.2012.04227.x. DO - 10.1111/j.1469-8137.2012.04227.x. M3 - Article. VL - 196. SP - 139. EP - 148. JO - The New Phytologist. JF - The New Phytologist. SN - 0028-646X. ER - ...
Genetic disorders of phosphate regulation | SpringerLink
Regulation of phosphate homeostasis is critical for many biological processes, and both hypophosphatemia and hyperphosphatemia can have adverse clinical consequences. Only a very small percentage (1%)
Numbers. Mosca
Photo by Liam Rickets Numbers present to you two slices of freewheeling 4x4 Mosca. Opening track Done Me Wrong unfurls perfectly, with all the hallmarks o
Bridging markers defining the map position of X linked hypophosphataemic rickets. - Oxford Neuroscience
Hypophosphataemic rickets is commonly an X linked dominant hereditary disorder associated with a renal tubular defect in phosphate transport and bone deformities. The gene causing this disorder has been mapped to Xp22.31----p21.3 by using cloned human X chromosome sequences identifying restriction fragment length polymorphisms (RFLPs) in linkage studies of affected families. The hypophosphataemic rickets gene locus (HPDR) was previously mapped distal to the X linked polymorphic locus DXS41 (99.6) but its position in relation to the distal loci DXS43 (D2) and DXS85 (782) was not established. In order to obtain a precise mapping of the disease locus in relation to these genetic loci, additional affected families informative for these X linked markers have been investigated. The combined results from the two studies have established linkage with the loci DXS41 (99.6) and DXS43 (D2); peak lod score for DXS41 (99.6) = 7.35, theta = 0.09, and peak lod score for DXS43 (D2) = 4.77, theta = 0.16. Multilocus
Hypophosphatemic bone disease | definition of hypophosphatemic bone disease by Medical dictionary
Looking for online definition of hypophosphatemic bone disease in the Medical Dictionary? hypophosphatemic bone disease explanation free. What is hypophosphatemic bone disease? Meaning of hypophosphatemic bone disease medical term. What does hypophosphatemic bone disease mean?
Living with genetic rickets | Archives of Disease in Childhood
Unless you actually have a metabolic bone disorder like hypophosphataemic rickets, you dont really know how it feels. Even if every member of your family has this syndrome, and so you experience the effects by proxy, you still cant feel it in your bones. But if youre the odd one out trying to understand how your family members feel, you can still be an important help-mate, and thats what this article is about. I want to describe how, within my family I have been coping with the chronic condition that affects us all.. The treatment for this particular kind of vitamin D resistant rickets (actually a historical misnomer, because many people affected by what is now called X linked hypophosphataemic rickets do, in fact, respond well to the active metabolite calcitriol, though processing of the native form, calciferol, is poorly regulated; another form of genetic rickets, involving the vitamin D receptor, is truly D resistant) has been pretty consistent over the past two decades. A combination ...
Increased risk of refeeding syndrome-like hypophosphatemia with high initial amino acid intake in small-for-gestational-age,...
BACKGROUND: Recent nutrition guidelines for extremely-low-birth-weight infants (ELBWIs) recommend implementation of high initial amino acid (AA) supplementation in parenteral nutrition.. OBJECTIVE: We sought to evaluate the influence of AA intake on refeeding syndrome-like electrolyte disturbances including hypophosphatemia in ELBWIs.. STUDY DESIGN: Medical records of 142 ELBWIs were reviewed. Demographic, nutritional, outcome, and electrolyte data were compared between ELBWIs with initial low (1.5 g/kg/day) and high (3 g/kg/day) AA intake. Multivariate analysis was conducted to determine the odds ratio of hypophosphatemia with high AA intake and small-for-gestational-age (SGA) ELBWIs.. RESULTS: The incidence of hypophosphatemia and severe hypophosphatemia increased from 51% and 8% in period I to 59% and 20% in period II, respectively (p = 0.36 and , 0.01). Specifically, SGA ELBWIs showed higher incidence of hypophosphatemia than appropriate-for-gestational age (AGA) ELBWIs in period II, whereas ...
Writing a song about weak bones and strong wills helped a Schnecksville musician cope with his rare disease - The Morning Call
Many people with rare diseases like X-linked hypophosphatemia feel lonely and lost because so few people share their experiences. Chris Younger, who has XLH, and his wife, Liz, recorded a song about the rare disease to raise spirits and make people feel connected to a community that has their back.
Comments on For This Mom, Rare Bone Disease Is a Family Affair
But throughout her life, Jones hasnt let the disease stop her from doing the things she wanted to do. As a child, she loved dancing and kept doing it despite injuries and her mothers objections.. Shes turned that drive into a career and is now the executive director of the XLH Network, a patient advocacy group.. For the past year, Jones and her children have been taking a newly available medication called burosumab (Crysvita) that helps the body retain phosphorus. She said it has eased her muscle pain and fatigue.. I didnt realize how tired I was until I wasnt anymore, she said. I really had no idea how exhausted I was.. Her kids are only 6 and 8 right now, so Jones is hoping the drug will help prevent some of the damage associated with the disease.. XLH is caused by a mutation in an X chromosome. Men have an X and a Y chromosome, so if they have XLH, they will always pass it on to their offspring. Because women have two X chromosomes, a woman with XLH has a 50-50 chance of passing the ...
Rickets - Symptoms, diagnosis and treatment | BMJ Best Practice
Rickets is deficient mineralisation at the growth plate of long bones, resulting in growth retardation. If the underlying condition is not treated, bone deformity occurs, typically causing bowed legs and thickening of the ends of long bones. Rickets only occurs in growing children before fusion o...
Symptoms and Treatment for Rickets
The bone disorder caused by acute deficiency of vitamin D, calcium, or phosphate is known as Rickets. Here are some symptoms & treatment options for rickets
rickets differential diagnosis
rickets differential diagnosis | Read Isabels blog on everything healthcare, with regular updates on our differential diagnosis tool and discussions about the healthcare industry.
Rickets, Ilse I ILR/0000 -- Discover Life
Discover Lifes page about the biology,
natural history, ecology, identification and distribution of Rickets, Ilse I_ILR/0000 -- Discover Life
Rachitisz - Lexikon
ang. rickets; magyarban angolk r, minthogy angolorvosok voltak az els k, kik e betegs gre felhivt k a figyelmet), ltal nos,teh t alkati megbeteged s, melynek f s jellegzetes t nete a csontre