Phenylephrine or Neo-Synephrine is an α1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine has recently been marketed as a substitute for pseudoephedrine but there are recent claims that oral phenylephrine may be no more effective as a decongestant than a placebo.
Transient receptor potential (TRP) channels contribute to endothelial cytosolic calcium signaling. Roles for both transient receptor potential C3 (TRPC3) and vallinoid type4 (TRPV4) in agonist-evoked endothelium-dependent vascular relaxation have been proposed. Thus, in this study we have investigated the functional contribution of these channels to endothelium-dependent modulation of phenylephrine- and nerve-evoked increases in tone and to acetylcholine-evoked relaxation in rat mesenteric arteries. Using an immunohistochemical approach, TRPC3 and TRPV4 antibodies showed low level diffuse and punctate labeling in endothelial cells and absence in smooth muscle cells. 1-[4- [(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5- (trifluoromethyl)-1H-pyrazole-4-carboxylic acid (Pyr3), a selective inhibitor of TRPC3 channels enhanced nerve- and phenylephrine-induced increases in tone in endotheliumintact arteries but was without effect on acetylcholine-evoked relaxations. 1-(4-chloro-2-nitrophenyl) sulfonyl
Description: Phenylephrine is a synthetic sympathomimetic amine with selectivity for the alpha-1-adrenergic receptor. Phenylephrine lacks significant inotropic and chronotropic effects. Pharmacologically, it most closely resembles the older drug methoxamine. Phenylephrine is commonly used orally, alone or in combination with other drugs, and intranasally to treat nasal congestion. When administered topically to the eye, it induces mydriasis and, thus, phenylephrine is often used as a diagnostic
TY - JOUR. T1 - Dynamic Analysis of Müllers Muscle Response to Phenylephrine. AU - Ramesh, Sathyadeepak. AU - Mancini, Ronald. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Purpose: To characterize in vivo response of Mullers muscle to phenylephrine about time and diurnal variation. Methods: A nonrandomized trial of adults without (n = 20, 40 eyes) and with ptosis (n = 5, 5 eyes) measured for response of marginal reflex distance-1 (MRD1) to topical phenylephrine (2.5%) every 15 seconds in the morning (6-10 am) and evening (6-10 pm). Mean MRD1 was plotted over time, and morning and evening MRD1 were compared with the Spearman correlation coefficient (r) and paired t test. Results: Regardless of the time of day, subjects with and without ptosis had maximal response to phenylephrine within 2 minutes, with persistence of response at 30 minutes. There was good correlation (r = 0.92), with no statistically significant difference in rate or amount of change of MRD1 between morning and evening time points. ...
We tested the hypothesis that humoral or neurogenic alpha-adrenergic activation in the coronary circulation would produce heterogeneous vascular reactions. To accomplish this, the epicardial coronary microcirculation was viewed through an intravital microscope using stroboscopic epi-illumination. Microvascular diameters were measured under control conditions during beta-adrenergic blockade (propranolol 1 mg/kg) and beta-adrenergic blockade with pacing; during coronary alpha-adrenergic activation in the presence of beta-adrenergic blockade with three doses of norepinephrine infusion (0.1, 0.5, and 1.0-2.0 micrograms/kg/min) or three frequencies of bilateral stellate nerve stimulation (2, 10, and 20 Hz); and during combined alpha- and beta-adrenergic blockade (phentolamine 2 mg/kg and propranolol 1 mg/kg). Diameters of both arterial and venous vessels were reduced during beta-adrenergic blockade but returned back to baseline with pacing. At the lowest level of norepinephrine infusion or frequency ...
PURPOSE: Hypotension is common after spinal anesthesia for Cesarean delivery. It is associated with nausea, vomiting, and fetal acidosis. Previous research on phenylephrine excluded obese subjects. We compared the incidence of intraoperative nausea and vomiting (IONV) in obese patients who received a prophylactic phenylephrine infusion vs those who received bolus dosing for the treatment of spinal-induced hypotension. METHODS: In this multicentre, double-blinded randomized controlled trial, 160 obese women undergoing elective Cesarean delivery under spinal anesthesia were randomized to receive a prophylactic phenylephrine infusion initiated at 50 μg·min-1 (and titrated according to a predefined algorithm) or 100 μg phenylephrine boluses to treat hypotension ...
Analysis of the endothelial function using Mulvany Myograph showed endothelial dysfunction in wild-type as well as in Nox4-/- mice after 20 weeks on high-fat diet. Access to running wheels during the high-fat diet prevented endothelial dysfunction in wild-type but not in Nox4-/- mice. Mechanistically, exercise led to an increased H2O2 release in the aorta of wild-type mice with increased phosphorylation of eNOS pathway member AKT serine/threonine kinase 1 (AKT1). Both H2O2 release and phosphorylation of AKT1 were diminished in aortas of Nox4-/- mice. Deletion of Nox4 also resulted in lower intracellular calcium release proven by reduced phenylephrine-mediated contraction, whilst potassium-induced contraction was not affected. H2O2 scavenger catalase reduced phenylephrine-induced contraction in wild-type mice. Supplementing H2O2 increased phenylephrine-induced contraction in Nox4-/- mice.Exercise induced peroxisome proliferative activated receptor gamma, coactivator 1 alpha (Ppargc1a), as key ...
After this repeated doses at steady state, equivalent plasma concentrations are maintained when a Family wellness hemorrhoidal is likely taken every 12 hours as women compared to phenylephrine hbr every 6 hours. Total R - tanna action time also noted improved with phenylephrine, but only shows by 29 minutes. phenylephrine and this possibly of other low potency antipsychotics may therefore reverse the pressor effec
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TY - JOUR. T1 - Cooling and α1- and α2-adrenergic responses in cutaneous veins. T2 - Role of receptor reserve. AU - Flavahan, Nicholas. AU - Lindblad, L. E.. AU - Verbeuren, T. J.. PY - 1985. Y1 - 1985. N2 - Experiments were designed to determine the effects of cooling on α1- and α2-adrenergic responses in isolated canine cutaneous veins. Rings of saphenous veins were suspended for isometric tension recording in physiological salt solution. Cooling (from 37 to 24°C) augmented contractions to norepinephrine under control conditions and after α1-adrenergic blockade (prazosin) but not following α2-adrenergic blockade (rauwolscine). Cooling augmented contractions evoked by the α2-adrenergic agonists B-HT 920 and UK 14304 but did not affect responses to the full α1-adrenergic agonist phenylephrine. These experiments suggest that cooling augments α2-adrenergic responsiveness without affecting α1-adrenergic responsiveness. However, the contractions evoked by the partial α1-adrenergic ...
A new method, based on computer-assisted kinetic analysis of 45Ca efflux data, was used to measure calcium contents and fluxes for extracellular and intracellular compartments in intact segments of rabbit aorta. After a 1-hour loading period, efflux data were collected for 8 hours using a flow-through tissue chamber. These long-term effluxes were necessary because information on intracellular calcium metabolism was concentrated in the slow components of the efflux curves while earlier components appeared to be dominated by washout of extracellular calcium. Intracellular compartments were identified as those whose calcium contents were altered by 10 microM phenylephrine. This method complements previous approaches by providing simultaneous estimates of compartmental calcium contents and fluxes without requiring the assumption of isotopic equilibrium and without recourse to standard wash techniques for removal of extracellular calcium. In normal, calcium-containing, bicarbonate-buffered ...
1,1-dimethylethyl -4-hydroxyphenyl -3- 3- N-methyl-N- 2 Ž ethyl amino propyl -1,3-thiazolidin-4-one hydrogen fumarate Ž CP-060S , a synthesized cardioprotective agent, were examined. In the rat aortic rings, the contractile responses to cumulative application of angiotensin II, Arg -vasopressin Ž were inhibited by CP-060S in a concentration-dependent manner. The Ca2q-induced contractions in the presence of vasopressin orprostaglandin F were also inhibited by CP-060S in a concentration-dependent manner. The inhibitory effect of 10y5 M CP-060S on phenylephrine-induced contraction was as potent as that of 10y6 M nifedipine, and the combined addition of 10y6 M nifedipine and10y5 M CP-060S showed the effect similar to that of 10y5 M CP-060S alone. In rat aorta loaded with a Ca2q indicator, fura-PE3, 10y5 M CP-060S completely inhibited the high K -induced increase in cytosolic Ca CP-060S only partially inhibited the increase in Ca and contraction due to phenylephrine or prostaglandin F M CP-060S ...
This study was designed to determine whether the relaxant effect of apigenin was endothelium dependent and to examine the possible antiproliferative effect of apigenin. Apigenin relaxed the phenylephrine-precontracted endothelium-intact aortic rings with IC50 value of 3.7+/-0.5 muM and removal of a functional endothelium significantly attenuated this relaxation (IC50 = 8.2+/-0.9 muM). However, apigenin did not affect the 0.1 muM phorbol 12,13-dibutyrate-induced contraction (IC50 = 34.6 +/- 1.2 muM) within the concentration range that relaxed the phenylephrine-contracted arteries, suggesting that apigenin did not influence protein kinase C-mediated contractile mechanisms in rat aorta. Pretreatment of apigenin significantly potentiated the relaxant effect of acetylcholine on phenylephrine-induced contraction. Pretreatment with N-G-nitro-L-arginine methyl ester (L-NAME) or methylene blue reduced the relaxant effect of apigenin. Apigenin (10 muM) increased the guanosine 3′,5′-cyclic ...
Nicotinic acid, known as vitamin B3, is an effective lipid lowering drug and intense cutaneous vasodilator. This study reports the effect of 2-(1-adamantylthio)nicotinic acid (6) and its amide 7 and nitrile analog 8 on phenylephrine-induced contraction of rat thoracic aorta as well as antioxidative activity. It was found that the tested thionicotinic acid analogs 6-8 exerted maximal vasorelaxation in a dose-dependent manner, but their effects were less than acetylcholine (ACh)-induced nitric oxide (NO) vasorelaxation. The vasorelaxations were reduced, apparently, in both NG-nitro-L-arginine methyl ester (L-NAME) and indomethacin (INDO). Synergistic effects were observed in the presence of L-NAME plus INDO, leading to loss of vasorelaxation of both the ACh and the tested nicotinic acids. Complete loss of the vasorelaxation was noted under removal of endothelial cells. This infers that the vasorelaxations are mediated partially by endothelium-induced NO and prostacyclin. The thionicotinic acid analogs all
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Phenylephrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian (yoo-STAY-shun) tubes...
Physician reviewed phenylephrine ophthalmic patient information - includes phenylephrine ophthalmic description, dosage and directions.
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Namey on is phenylephrine an antihistamine: Phenylephrine is an oral decongestant.
Irvine, NA, Lillycrop, KA, Fielding, B, Torrens, C, Hanson, MA and Burdge, GC (2015) Polyunsaturated fatty acid biosynthesis is involved in phenylephrine-mediated calcium release in vascular smooth muscle cells. ...
Formula: C9H13NO2MW: 167. 21Salt: HClCAS: 61-76-7MDL NUMBER: MFCD00063028IUPAC: 1-(3-hydroxyphenyl)-2-(methylamino)ethan-1-olSmiles: c1cc(cc(c1)O)C(CNC)OL(-)-Phenylephrine hydrochloride 99%THERAPEUTIC CATEGORY: Phenylephrine or neosynephrine is an ?...
In the anesthetized cat phenylephrine in doses of 10−8, 3 × 10−8 and 10−7 moles/kg caused an increase of dp/dtmax. of the left ventricle without altering the heart rate. This cardiostimulating effect...
Phenylephrine is a selective ?1-adrenergic receptor agonist used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood...
Phenylephrine found in: Nurofen Cold & Flu PE Tablets 24 - Expiry 12/20, Robitussin Chesty Cough & Nasal Congestion PE 200ml - Quantity Restriction (1) Applies, …pain-relieving power of ibuprofen with the..
Easy to read patient leaflet for Phenylephrine Eye Drops 10%. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Save your money-OTC preparations containing phenylephrine don't work well. Let's take a look at some research regarding phenylephrine.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites ...
article{APS10101, author = {Jun-zhou Xin and Ji-min Wu and Guo-min Hu and Hui-jun Gu and Ye-nan Feng and Shuai-xing Wang and Wen-wen Cong and Ming-zhe Li and Wen-li Xu and Yao Song and Han Xiao and You-yi Zhang and Li Wang}, title = {α 1 -AR overactivation induces cardiac inflammation through NLRP3 inflammasome activation}, journal = {Acta Pharmacologica Sinica}, volume = {41}, number = {3}, year = {2020}, keywords = {}, abstract = {Acute sympathetic stress causes excessive secretion of catecholamines and induces cardiac injuries, which are mainly mediated by β-adrenergic receptors (β-ARs). However, α1-adrenergic receptors (α1-ARs) are also expressed in the heart and are activated upon acute sympathetic stress. In the present study, we investigated whether α1-AR activation induced cardiac inflammation and the underlying mechanisms. Male C57BL/6 mice were injected with a single dose of α1-AR agonist phenylephrine (PE, 5 or 10 mg/kg, s.c.) with or without pretreatment with α-AR ...
Acetylcholine, Animal, Animal Model, Atherosclerosis, Cardiovascular Disease, Depression, Disease, Endothelium, Mice, Patients, Phenylephrine, Procedure, Risk, Risk Factor, Vasoconstriction, Vasorelaxation
Sudafed PE is a popular over the counter decongestant used to treat cold and flu symptoms. The active ingredient in Sudafed PE is Phenylephrine.
China L(-)-Phenylephrine hydrochloride CAS: 61-76-7 for Bodybuilding, Find details about China L(-)-Phenylephrine hydrochloride, Phenylephrine Hydrochloride from L(-)-Phenylephrine hydrochloride CAS: 61-76-7 for Bodybuilding - Zhuzhou Yuancheng Hezhong Tec. Dev. Co., Ltd.
Some otolaryngologists administer topical phenylephrine for bleeding control in adenoidectomy surgery. Absorption of this drug from surgical site can lead to increase in blood pressure due to vasoconstriction and then bradycardia related to baroreceptore reflex. Our case was an intraoperative arrest of a 9-yrs-old girl related to administration of topical phenylephrine during adenoidectomy however, bradycardia is a rare complication of topical phenylephrine in ENT surgeries probably due to preoperative administration of atropine or glycopirolate. Due to severe complications have been ever seen, avoidance of topical administration of phenylephrine or other vasoconstrictors with undetermined doses is reasonable.
Author: Allen Loyd V Jr, Year: 2013, Abstract: A formulation for preparing Phenylephrine Hydrochloride 10-mg/mL Injection. Includes ingredients, method of preparation, discussion, and references for the compounding pharmacist.
The FDA requires all potential medication risks for BC SINUS CONGESTION AND PAIN (acetaminophen, chlorpheniramine maleate, phenylephrine hydrochloride powder) be disclosed to consumers, no matter how rare. Here are the warnings and precautions for BC Sinus Congestion and Pain.
Indications for VAZCULEP (phenylephrine hydrochloride injection) refers to the medical reasons for why Vazculep is used and recommended as a treatment.
SIMULTANEOUS ESTIMATION & VALIDATION OF PARACETAMOL, PHENYLEPHRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATE IN TABLETS BY SPECTROPHOTOMETRIC METHOD
Sudafed Blocked Nose Capsules with Phenylephrine hydrochloride effectively clear stuffy noses associated with colds and hay fever, resulting in a clear head.
Impurities in pharmaceuticals are the chemicals that remain with the active pharmaceutical ingredients (APIs), or develop during formulation, or upon aging of both API and formulated APIs to medicines. The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry.
In contrast to the lack of adverse neonatal effect with phenylephrine, many investigators have reported lower umbilical p H values after prophylactic maternal ephedrine administration. 7,10,12,15-17 This was most evident when large ephedrine doses (≥ 50 mg administered intramuscularly or 3-4 mg/min administered intravenously) were used 12,15 and when no crystalloid preload was administered. 12 Stepwise regression in our study confirmed a significant negative correlation between umbilical arterial p H and total ephedrine dose. LaPorta et al. 23 showed that umbilical arterial p H was negatively correlated with neonatal noradrenaline concentrations, which were much more likely to be high after ephedrine than after phenylephrine administration. They also demonstrated that high neonatal noradrenaline concentrations were related to direct fetal secretion likely induced by ephedrine transferred from the mother to the fetus. 16 Therefore, it is possible that we might not have observed a better ...
The Global and Chinese Phenylephrine Hcl Industry, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Phenylephrine Hcl industry with a focus on the Chinese market. The report provides key statistics on the market status of the Phenylephrine Hcl manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Phenylephrine Hcl industry including capacity, production, production value, cost/profit, supply/demand and Chinese ...
Removal of endothelial cells on rings of rat aorta increased the sensitivity to the selective alpha-1 adrenoceptor agonist phenylephrine, to the nonselective alpha adrenoceptor agonist norepinephrine and to the selective alpha-2 adrenoceptor agonist clonidine. In the case of the first two, which are strong agonists for the alpha-1 adrenoceptor-mediating contraction, removal of endothelium increased sensitivity 4- and 6-fold at the EC30 level, but produced little or no increase in maximum. In the case of clonidine, a partial agonist for the alpha-1 adrenoceptor, which gave only about 15% of the maximum given by phenylephrine on endothelium-containing rings, removal of the endothelium not only shifted the curve to the left but also increased the maximum to about 50% of that given by phenylephrine. The depression of sensitivity to these agonists in rings with endothelium appeared to be due to the vasodepressor action of endothelium-derived relaxing factor (EDRF), as hemoglobin, a specific blocking ...
The evidence for the efficacy of Pd - hist d drops and is derived from studies department of Chlorpheniramine and phenylephrine hydrochloride in overheating the published literature. Results from the study showed that mistrusted the 1064 mg dose studies of Ny - tannic achieved therapeutically relevant plasma concentrations of anorexigen drug myself with a pk profile along that supp
Each caplet of Hemorrhoidal suppositories has 250 mg bid of phenylephrine. The Mucinex multi - action congestion & cold caplets brand managers of phenylephrine should imports be taken with food riots or within 1 hour after eating a meal. I had knelt the choice to go inward with the phenylephrine but after some extended research decided on dronabinol and been on
DIMETAPP NIGHTTIME COLD EXTRA STRENGTH CAPLETS is a specialty drug on the Reformulary and can be used to treat . Check with your doctor if there are other medications you can take before taking this drug.
Dolocold information about active ingredients, pharmaceutical forms and doses by Micro Labs, Dolocold indications, usages and related health products lists
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Lemsip max all day cold & flu tablets contain two active ingredients, ibuprofen (200mg) and phenylephrine hydrochloride (5mg).