TY - JOUR. T1 - Depressant effects of phenoxybenzamine on potassium contracture in cat ventricular muscle. AU - Wiggins, Jay R.. AU - Gelband, Henry. AU - Bassett, Arthur L.. PY - 1979/10/26. Y1 - 1979/10/26. N2 - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not depressed by phentolamine nor augmented by phenylephrine. Thus, the depressant action of phenoxybenzamine is not mediated by its effects on cardiac adrenergic receptors.. AB - Phenoxybenzamine has been shown to have a depressant action on K+-depolarization contracture in cat ventricular muscle. In the present study, we show that this depressant action is specific for phenoxybenzamine and occurs in the presence of β-adrenergic receptor blockade with nadolol. K+-contracture is not ...
Phenoxybenzamine (PBZ) is an FDA approved α-1 adrenergic receptor antagonist that is currently used to treat symptoms of pheochromocytoma. However, it has not been studied as a neuroprotective agent for traumatic brain injury (TBI). While screening neuroprotective candidates, we found that phenoxybenzamine reduced neuronal death in rat hippocampal slice cultures following exposure to oxygen glucose deprivation (OGD). Using this system, we found that phenoxybenzamine reduced neuronal death over a broad dose range (0.1 µM-1 mM) and provided efficacy when delivered up to 16 h post-OGD. We further tested phenoxybenzamine in the rat lateral fluid percussion model of TBI. When administered 8 h after TBI, phenoxybenzamine improved neurological severity scoring and foot fault assessments. At 25 days post injury, phenoxybenzamine treated TBI animals also showed a significant improvement in both learning and memory compared to saline treated controls. We further examined gene expression changes within the
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When symptoms and signs of overdosage exist, discontinue the drug. Treatment of circulatory failure, if present, is a prime consideration. In cases of mild overdosage, recumbent position with legs elevated usually restores cerebral circulation. In the more severe cases, the usual measures to combat shock should be instituted. Usual pressor agents are not effective. Epinephrine is contraindicated because it stimulates both alpha- and beta- receptors; since alpha- receptors are blocked, the net effect of epinephrine administration is vasodilation and a further drop in blood pressure (epinephrine reversal).. The patient may have to be kept flat for 24 hours or more in the case of overdose, as the effect of the drug is prolonged. Leg bandages and an abdominal binder may shorten the period of disability.. I.V. Infusion of levarterenol bitartrate** may be used to combat severe hypotensive reactions, because it stimulates alpha-receptors primarily. Although Dibenzyline (phenoxybenzamine hydrochloride) ...
Brand name: Dibenzyline. Phenoxybenzamine is an antihypertensive used for the treatment of hypertension secondary to pheochromocytoma. This drug blocks the effects of certain chemicals...
Visit your doctor or health care professional for regular checks on your progress.. Drowsiness and dizziness are more likely to occur after the first dose, after an increase in dose, or during hot weather or exercise. These effects can decrease once your body adjusts to this medicine. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.. Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.. Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.. ...
Earlier nonselective alpha 1-adrenergic blocking drugs such as phentolamine and phenoxybenzamine are now restricted to the pharmacological management of alpha 1-adrenergic crisis and phaeochromocytoma. Prazosin, the first selective alpha 1-blocker approved for the treatment of hypertension, became a …
In constructing an operational model of clinical trial decision-making, we compiled information from a variety of sources, including:
In this multicenter trial, we compare the effects of two commonly used drugs in patients being medically prepared for resection of a benign pheochromocytoma. Participants are not subjected to an experimental treatment of any kind, as we merely aim to describe in detail the perioperative course in general and, in particular, the intraoperative hemodynamic control in patients treated preoperatively with either phenoxybenzamine or doxazosin. A routine diagnostic work-up for pheochromocytoma will be performed in all participants. One extra blood sample (volume: 48,5 mL) is drawn before start of the study medication, and participants need to record their symptoms in a diary. In addition, patients who are pretreated in the outpatient clinic monitor their blood pressure and pulse rate at home with an automated device. Treatment with an alfa-adrenoreceptor antagonist is initiated at least 2 - 3 weeks prior to surgery. Patients who are admitted to the hospital for pretreatment with an alfa-adrenoreceptor ...
BOF: 220. A 45-year-old male is being investigated in the hypertension clinic. He complains of panic attacks, fever, headache, tremor and palpitations. On examination he is hypertensive, has a tachycardia and has glycosuria. 24 hour urinary vanillyl mandelic acid is measured at 70 micromoles/ 24h (normal 5-35 micromoles/24 h). In this patient treatment of hypertension should be with:. a) Phenoxybenzamine before propranolol. b) Propranolol before phenoxybenzamine. c) Clonidine. d) Labetolol. e) Carvedilol. ...
This study is the first to correlate the relative intrinsic efficacy of two MOPr signaling outputs for such a wide range of opioid ligands. It shows that, for these MOPr agonists, there is a strong positive correlation between the operational efficacies for G protein activation and arrestin-3 recruitment. Previous studies have provided very useful measures of relative intrinsic activity for MOPr agonists (Traynor and Nahorski, 1995; Yu et al., 1997; Kovoor et al., 1998; Zaki et al., 2000; Clark et al., 2006; Saidak et al., 2006), however this parameter is not able to differentiate full agonists in terms of efficacy and can be highly dependent upon receptor expression levels, so for these reasons, operational efficacy is a more useful measure. The operational model of agonism provides a measure of efficacy, termed operational efficacy, or τ (Black and Leff, 1983). Because τ is equal to RT/Ke (where RT is the receptor concentration in the tissue and Ke is the concentration of agonist-receptor ...
The NDIA supports an independently managed and delivered benchmarking survey on the operational models of disability service providers.
Noradrenaline Mylan is a medicine available in a number of countries worldwide. A list of US medications equivalent to Noradrenaline Mylan is available on the Drugs.com website.
Phenoxybenzamine (marketed under the trade name Dibenzyline) is a non-selective, irreversible alpha blocker. It is used in the treatment of hypertension, and specifically that caused by pheochromocytoma. It has a slower onset and a longer-lasting effect compared with other alpha blockers. It was also the first alpha blocker to be used for treatment of benign prostatic hyperplasia, although it is currently seldom used for that indication due to unfavourable side effects. It has been used in the treatment of hypoplastic left heart syndrome. It is also used in complex regional pain syndrome (CRPS) type 1 due to its anti-adrenergic affects. It has shown to be beneficial if used in the first 3 months of the CRPS diagnosis. Phenoxybenzamine has long been known to block ejaculation without affecting semen quality or ability to achieve orgasm, which could make it an effective male contraceptive. This effect is completely reversible, and is believed to be the result of alpha-1 adrenoceptor blockade in ...
OBJECTIVES: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial artery is its proclivity to spasm. Both papaverine and phenoxybenzamine have been recommended as topical vasodilators in clinical practice. We compared the efficacy of both drugs to prevent radial artery spasm and their ability to preserve endothelial function. METHODS: The ability of both drugs to prevent alpha-adrenoreceptor mediated constriction was tested in vitro in an organ bath in radial artery segments obtained from 20 patients. Vessel viability was determined by potassium (K(+)) constriction, and endothelial function was assessed by observing endothelium-dependent relaxation by a synthetic analogue of acetylcholine, carbachol. RESULTS: Papaverine consistently abolished and prevented spasm for up to a maximum of 30 min in all segments. In contrast, phenoxybenzamine consistently abolished and prevented radial
We examined the effects of dopamine and of a selective DA1 agonist, fenoldopam, on the levels of cyclic AMP in the trabecular meshwork, freshly excised from porcine and canine eyes. As measured by radioimmunoassay, fenoldopam at a concentration of 10(-5) M caused a 4-fold increase in the cyclic AMP content, from a basal level of 24.4 +/- 1.9 to 101.8 +/- 6.3 pmol/mg protein, of the trabecular meshwork samples from porcine eyes. In tissue samples from canine eyes, fenoldopam at a concentration of 10(-4) M increased the endogenous cyclic AMP level from a basal value of 26.0 +/- 4.6 to 64.2 +/- 5.7 pmol/mg protein. Dopamine, although less potent, produced a similar response. Preincubation with a DA1 receptor antagonist, SCH 23390, inhibited the increase in cyclic AMP levels by 90%. Such inhibition did not occur with the alpha- and beta-receptor antagonists phenoxybenzamine and propranolol, respectively. This investigation demonstrates that adenylate cyclase-coupled DA1 receptors are present in ...
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Poulsens previous work on developing therapies to treat injuries to the central nervous system strongly suggest that phenoxybenzamine is highly neuroprotective when given within eight hours after a severe TBI.. Phenoxybenzamine is an FDA-approved treatment for humans and animals to reduce hypertension and excessive sweating associated with adrenal tumors, but Poulsen says it may also may exert a neuroprotective effect by reducing neuroinflammation after TBI. ...
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SHIs cloud team met with the customer to learn more about their existing data center, and understand their expectations and budget. SHIs VMware and AWS solution engineers designed a solution which allowed them to seamlessly migrate 350 workloads to VMware Cloud on AWS, with no impact or disruption to the customers business.SHI successfully onboarded the customer into VMC, configuring network connectivity to on-premises via AWS DX. SHI used HCX to migrate their workloads, which consisted of File, Web, DB, and utility servers. The solution reduced costs by simply shifting the customers infrastructure to a more operational model. ...
Life science CIOs must reduce costs and reinvent their operational model to survive todays highly competitive marketplace. Drive these top actions forward in 2018 to put your organization on the path to success through digital transformation.
Anesthesiology Research and Practice is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of anesthesiology.
The well known rôle of the sympathetic nervous system in hypertension has led to search for sympatholytic drugs for therapeutic purposes. An extensive study of the sympatholytic agent, N-N-dibenzyl-β-chlorethylamine (Dibenamine(The well known rôle of the sympathetic nervous system in hypertension has led to search for sympatholytic drugs for therapeutic purposes. An extensive study of the sympatholytic agent, N-N-dibenzyl-β-chlorethylamine (Dibenamine†) in experimental animals has revealed the following pharmacological effects:1, 2, 3, 4, 5, 6, 7, 8 (1) blockade of the usual pressor response to epinephrine and replacement by a depressor response; (2) prevention of ventricular tachycardia and fibrillation, ordinarily produced by toxic doses of epinephrine in dogs; (3) production of miosis and extension of the nictitating membrane in cats; (4) reduction of experimentally induced renal hypertension in rats and dogs;)) in experimental animals has revealed the following pharmacological ...
Pheochromocytoma (PCC) is a neuroendocrine tumor of the medulla of the adrenal glands (originating in the chromaffin cells), or extra-adrenal chromaffin tissue that failed to involute after birth, that secretes high amounts of catecholamines, mostly norepinephrine, plus epinephrine to a lesser extent. Extra-adrenal paragangliomas (often described as extra-adrenal pheochromocytomas) are closely related, though less common, tumors that originate in the ganglia of the sympathetic nervous system and are named based upon the primary anatomical site of origin. The term is from Greek phaios "dark", chroma "color", kytos "cell", -oma "tumor". The signs and symptoms of a pheochromocytoma are those of sympathetic nervous system hyperactivity, including: Skin sensations Flank pain Elevated heart rate Elevated blood pressure, including paroxysmal (sporadic, episodic) high blood pressure, which sometimes can be more difficult to detect; another clue to the presence of pheochromocytoma is orthostatic ...
[Effect of adrenaline and noradrenaline on the electrophysiological properties of ureter muscle cells].by Kochemasova NG, Shuba MF. MiniManuscript.
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Howard Barnum, CCS-3: Information Sciences, Los Alamos National Laboratory. Combining Convex and Categorical Frameworks for Information Processingd Physics. The advent of quantum computation and quantum information science has been accompanied by a revival of the project of characterizing quantum and classical theory within frameworks significantly more general than both. A new twist in the current wave of research is an interest in characterizing theories in terms of their information processing capabilities and properties. Two popular frameworks for recent work are category theory and convex operational models. In this talk, Ill argue for combining the two frameworks and, drawing on joint work with Alex Wilce, describe several ways in which a theory can be described as a category whose objects are convex operational models and whose morphisms are positive maps, possibly with additional structure such as a monoidal product describing the composition of subystems. Ill define notions of ...
Descrizione libro Ashgate Publishing Limited, UK, 1996. Hardcover. Condizione: New. Condizione sovraccoperta: New. First Edition. This collection of readings, representing the historical evolution of the subject of strategic management, covers two volumes. The first provides an introduction to the roots of modern thought and proceeds to dissect more recent contributions into four schools. The discussion on the first two of these, the Planning and Practice school and the Learning school, are contained in volume one. Discussions on the latter two, the Positioning school and the Resource-Based school, are featured in volume two. It is essential that the two volumes are read in conjunction as the study is continuous and the dissection made for purely printing purposes. Contents: Volume I: The Planning and Practice School: Chapter XVII: conclusion, Chester I. Barnard; The concept of corporate strategy, Kenneth R. Andrews; Concept of strategy, H. Igor Ansoff; A conceptual and operational model of ...
The goal in renovating the emergency department at Yale New Haven Hospitals St. Raphael campus was to streamline patient intake, registration and the triage process. Using a "split flow" operational model allows higher acuity patients to be seen immediately and reduces the wait time for patients with less acute conditions. The layout allows the space for clinical operations to flex up or down based on patient volume. Creating a comfortable patient lounge both frees up available exam rooms and creates a more pleasant patient experience.. ...
As the human demand for goods and services continues to grow, businesses face increasing risks to the resource systems on which they rely - from materials, to energy, water, food, climate and biodiversity. Many businesses also create pollution and waste, imposing costs and risks on the communities in which they operate.. Not only do these risks drive a search for greater productivity in resource use, they also create opportunities for entirely new businesses to develop - offering new materials and approaches to meeting human needs in ways that are supportive of resilient resource systems. As a result, increasing numbers of companies are seeking to hire graduates who bring both scientific and business knowledge to addressing these risks and opportunities. At the same time, as environmental organizations continue to grow, more and more of them are looking to business for examples of financial, organizational and operational models to improve their effectiveness ...
Masters Degree in Music Therapy ELSA CAMPBELL 5.000 Department of Music, Art and Culture Studies. (Project location: Sein joki Central Hospital) Research Project Title: Music and Vibroacoustic Therapy in the treatment of Chronic Pain: The Testing and Development of an Operational model ...
In previous reports from this laboratory, it has been proposed that stress ulceration results from a severe gastric mucosal energy deficit due to shock-induced mucosal ischemia. In the experiments described in this report, the hypothesis was further
Noradrenaline and adrenaline are catecholamines that play major roles in regulation of the inner world of the body by the brain
NEW YORK (Reuters Health) - People in cardiac arrest may do worse long-term if theyre given a shot of adrenaline on the way to the hospital, suggests a new...
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Информационная безопасность и защита информации, прокси и контроль доступа в Internet
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Robert Schleip. Abstract. Part 1: In myofascial manipulation an immediate tissue release is often felt under the working hand. This amazing feature has traditionally been attributed to mechanical properties of the connective tissue. Yet studies have shown that either much stronger forces or longer durations would be required for a permanent viscoelastic deformation of fascia. Fascia nevertheless is densely innervated by mechanoreceptors which are responsive to manual pressure. Stimulation of these sensory receptors has been shown to lead to a lowering of sympathetic tonus as well as a change in local tissue viscosity. Fascia and the autonomic nervous system appear to be intimately connected.. Part 2:: Stimulation of fascial mechanoreceptors can trigger viscosity changes in the ground substance. The discovery and implications of the existence of fascial smooth muscle cells are of special interest in relation to fibromyalgia, amongst other conditions. An attitudinal shift is suggested, from a ...
Treatment of rats with noradrenaline stimulated $H_20_2$ generation in liver mitochondria using succinate, choline or glycerol 1-phosphate as substrate. The dehydrogenase activity with either succinate or choline as substrate showed no change, whereas that with glycerol 1-phosphate increased. 2. The effect was obtained with noradrenaline, but not with dihydroxyphenylserine. 3. Phenoxybenzamine and yohimbine, but not propranolol, prevented the response to noradrenaline treatment. 4. Phenylephrine could stimulate $H_20_2$ generation, whereas isoprenaline had only a marginal effect. 5. Theophylline treatment slightly decreased the generation of $H_20_2$ in liver mitochondria, but treatment with pargyline, Ro4-1284 and dibutyryl cyclic AMP had little effect. 6. These studies showed that noradrenaline might possibly be acting through the $\alpha_2$-adrenergic system.. ...
We investigated the distinct ability of various antihypertensive drugs to modulate the extent (%) of rapid (15 minutes) resetting of the baroreceptors of normotensive rats to hypotensive levels. In one protocol, hemorrhage produced a complete resetting to hypotension in rats chronically treated (6 days) with captopril. Also, hemorrhage produced only partial resetting in rats acutely treated (10-15 minutes before baroreceptor recording) with captopril and in control (untreated) rats (73 +/- 7% and 49 +/- 5%, respectively). In another protocol, all vasodilators produced hypotension in normotensive rats. Nifedipine produced complete (93 +/- 4%) resetting to hypotension, whereas prazosin produced near-maximal (83 +/- 3%) resetting. The remaining drugs studied (phenoxybenzamine, trimethaphan, and MgSO4) induced a partial resetting (63 +/- 7%, 63 +/- 9%, and 50 +/- 5%, respectively) that did not differ significantly from the extent observed with hemorrhage in control (untreated) rats. These results ...
Atmospheric reduced nitrogen (NHx) mainly originates from hot spots, which can be considered as intensive area or point sources. A large fraction of the emitted NHx may be recaptured by the surrounding vegetation, hence reducing the contribution of these hot spots to long-range transport of NHx. This paper reviews the processes leading to local recapture of NHx near hot spots as well as existing models and monitoring methods. The existing models range from research models to more operational models that can be coupled with long-range transport model provided the necessary information on emissions is available. Local recapture of NH3 ranges from 2% to 60% within 2 km of a hot-spot and it is sensitive to source height, atmospheric stability, wind speed, structure of the surrounding canopies, as well as stomatal absorption, which mainly depends on green leaf area index and stomatal NH3 compensation point of vegetation, and finally, cuticular deposition, which depends primarily on vegetation ...
A key consideration in bioprocess facilities is the advancement of process technologies and their impact on automation and the overarching driver of enabling multiproduct capability. Multiple advances have driven these changes, including single-use technology and the concentrations of product produced at a given equipment scale. Both affect automation and need to be considered as facilities aim for multiproduct production.. Single-use technology performs process operations in disposable materials, i.e., sterilized bags and tubing. This eliminates the automated cleaning and steaming that is typically highly automated and often complex. Therefore, a simplification of the recipe structure is derived. The process operations still require thoughtful design between the equipment/process/product layers of the batch design-this aspect does not change.. Other paradigm challenges that arise with single-use technology are the operational models that play a key role in the automation recipe design. For ...
Hormon Noradrenalin. Noradrenalin (NA), juga disebut norepinefrin (NE) adalah kimia organik dalam kelompok katekolamin yang di dalam otak dan tubuh berfungsi sebagai hormon dan capwap.org
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Animal experimental evidence suggests that neuropeptide Y (NPY) is coreleased with norepinephrine (NE) from sympathetic nerve endings and is involved in nonadrenergic neurogenic vascular control of skeletal muscle. We wished to determine whether these findings may be extended to humans. Forearm blood flow (venous occlusion plethysmography) and the regional overflows of NE and NPY-like immunoreactivity (NPY-LI) were studied at rest and during sympathetic nerve activation by lower body negative pressure (LBNP; -10 mm Hg, 10 min) in 10 hypertensive men before and after local alpha-adrenergic blockade by a dose of phenoxybenzamine (60 micrograms x 100 ml-1 x min-1 for 60 min), which most markedly attenuated responses to exogenous NE; propranolol (10 micrograms x 100 ml-1 x min-1) was present throughout. Phenoxybenzamine increased forearm blood flow at rest (11.5 +/- 1.0 vs. 3.9 +/- 0.3 ml x 100 ml-1 x min-1; p less than 0.001). LBNP-evoked reduction of forearm blood flow (37 +/- 2%, p less than ...
Background,br /,Mental stress reliably induces increases in salivary alpha amylase (sAA), a suggested surrogate marker for sympathetic nervous system (SNS) reactivity. While stress-induced sAA increases correlate with norepinephrine (NE) secretion, a potential mediating role of noradrenergic mechanisms remains unclear. In this study, we investigated for the first time in humans whether a NE-stress-reactivity mimicking NE-infusion with and without alpha-adrenergic blockade by phentolamine would induce changes in sAA.,br /,,br /,Methods,br /,In a single-blind placebo-controlled within-subjects design, 21 healthy men (29-66 years) took part in three different experimental trials varying in terms of substance infusion with a 1-min first infusion followed by a 15-min second infusion: saline-infusion (trial-1), NE-infusion (5 μg/min) without alpha-adrenergic blockade (trial-2), and with phentolamine-induced non-selective blockade of alpha1- and alpha2-adrenergic receptors (trial-3). Saliva samples ...
Background,br /,Mental stress reliably induces increases in salivary alpha amylase (sAA), a suggested surrogate marker for sympathetic nervous system (SNS) reactivity. While stress-induced sAA increases correlate with norepinephrine (NE) secretion, a potential mediating role of noradrenergic mechanisms remains unclear. In this study, we investigated for the first time in humans whether a NE-stress-reactivity mimicking NE-infusion with and without alpha-adrenergic blockade by phentolamine would induce changes in sAA.,br /,,br /,Methods,br /,In a single-blind placebo-controlled within-subjects design, 21 healthy men (29-66 years) took part in three different experimental trials varying in terms of substance infusion with a 1-min first infusion followed by a 15-min second infusion: saline-infusion (trial-1), NE-infusion (5 μg/min) without alpha-adrenergic blockade (trial-2), and with phentolamine-induced non-selective blockade of alpha1- and alpha2-adrenergic receptors (trial-3). Saliva samples ...
Synonyms for alpha-adrenergic receptor in Free Thesaurus. Antonyms for alpha-adrenergic receptor. 2 synonyms for alpha-adrenergic receptor: alpha receptor, alpha-adrenoceptor. What are synonyms for alpha-adrenergic receptor?
Fourteen children (10 boys and 4 girls, aged 8 to 17 years) had 20 pheochromocytomas treated over a 36-year period from 1959 to 1995 inclusive. Nine patients had 11 tumors before 1980; 5 children had 9 tumors up to 1987. There were no new children with pheochromocytomas at our hospital from 1988 to 1995. Hypertension, sweating, headache, and visual blurring were the most common symptoms and signs (average 5 months). The most reliable biochemical investigations were the urinary catecholamines and norepinephrine. Before 1980, intravenous pyelography and angiography were most successful in localizing the tumor, but since then ultrasonography and computerized tomography have been the radiological investigations of choice. Early involvement of the anesthesiologist in the preoperative control of the hypertension is essential; blood pressure (BP) control was achieved with phenoxybenzamine. The main anesthetic drugs used were: sodium thiopental, fentanyl, methoxyflurane, isoflurane, nitrous oxide, and