Raynaud phenomenon is known to occur in around 10% of the healthy female population and in around 5% of men. In the vast majority of cases, the blood vessels show no evidence of damage. In this case - so called Primary Raynaud phenomenon - the issue appears to be exaggerated spasm of healthy blood vessels.. Raynaud phenomenon is also the most common first symptom of scleroderma and is an important feature in other rheumatologic illnesses such as lupus. In this situation, the blood vessels are damaged and the opening for blood flow is much reduced. Raynaud episodes in scleroderma may reflect normal blood vessel constriction in response to cold superimposed on the narrow plumbing.. Blood flow to the fingers in normal health is around 40 times as much as is needed for oxygen supply and tissue nutrition. When the body is hot, blood flow increases to the hands so as to dissipate heat. This is much like a dog panting on a hot day. Conversely, when the body is cold, it is normal to reduce blood flow to ...
Plaquenil For RaynaudS Syndrome. anyone been prescribed Hydroxychloroquine for raynauds anyone been prescribed Hydroxychloroquine for raynauds I take hydroxychloroquine fir sjogrens syndrome Im not sure that it has helped with the Raynauds, Plaquenil and Raynauds disease - Reviews - TreatoPlaquenil and Raynauds disease . but with him it is a primary raynauds, I would say that you might have been suffering from Raynauds Syndrome and Plaquenil Raynauds PhenomenonInformation for patients with Raynauds phenomenon: what it is, common causes, getting diagnosed, treatment options, and tips for living with the condition.Our Top 5 Tips for Raynauds buy cialis Syndrome - Conquering SjogrensI started having symptoms of Raynauds Syndrome when I was very young. I was diagnosed with Sjogrens 2 and 1/2 years ago. I am taking Plaquenil and the About Raynauds Disease - Lupus Resource CenterRaynauds is a common overlapping condition with lupus viagra alternatives that can cause numbness in the About ...
Plaquenil For RaynaudS Syndrome. anyone been prescribed Hydroxychloroquine for raynauds anyone been prescribed Hydroxychloroquine for raynauds I take hydroxychloroquine fir sjogrens syndrome Im not sure that it has helped with the Raynauds, Plaquenil and Raynauds disease - Reviews - TreatoPlaquenil and Raynauds disease . but with him it is a primary raynauds, I would say that you might have been suffering from Raynauds Syndrome and Plaquenil Raynauds PhenomenonInformation for patients with Raynauds phenomenon: what it is, common causes, getting diagnosed, treatment options, and tips for living with the condition.Our Top 5 Tips for Raynauds buy cialis Syndrome - Conquering SjogrensI started having symptoms of Raynauds Syndrome when I was very young. I was diagnosed with Sjogrens 2 and 1/2 years ago. I am taking Plaquenil and the About Raynauds Disease - Lupus Resource CenterRaynauds is a common overlapping condition with lupus viagra alternatives that can cause numbness in the About ...
Looking for online definition of Raynaud syndrome in the Medical Dictionary? Raynaud syndrome explanation free. What is Raynaud syndrome? Meaning of Raynaud syndrome medical term. What does Raynaud syndrome mean?
Looking for online definition of Raynaud in the Medical Dictionary? Raynaud explanation free. What is Raynaud? Meaning of Raynaud medical term. What does Raynaud mean?
Reversible vasospasm of the extremities occurs as an isolated symptom in the absence of underlying disease (primary Raynaud phenomenon) or in association with other disorders (secondary Raynaud phenomenon). It has been reported that Raynaud phenomenon is associated with connective tissue diseases, but the frequency and types of diseases that eventually develop are not well established. Spencer-Green conducted a systematic literature search to assess the rates and predictors of transition to secondary disease after a primary diagnosis of Raynaud phenomenon.. A total of 639 patients with primary Raynaud phenomenon were identified from 10 studies. The average length of study follow-up was four years. The average duration of Raynaud phenomenon in the study subjects was 12.3 years. During follow-up, 12.6 percent (81 patients) developed a secondary disorder. Eighty of these cases were connective tissue diseases. Two thirds of the cases of connective tissue disease were attributed to systemic ...
Raynauds Syndrome. Raynauds phenomenon. Raynauds disease. Cold hands? Cold fingers? Cold feet? Cold toes? The Haven Healing Centre. Complementary Therapy in Bristol, Bath and Surrounding Area. Philip Chave, Healer and Therapist
Raynauds Disease, Raynauds Syndrome, Raynauds Phenomenon all refer to a vascualar condition affecting the feet and hands. Podiatrist Brisbane
Vibration White Finger or VWF is caused by the vibrations from power tools such as drills, chainsaws or hammers. Using such tools is common practice in many construction and industry working environments.. If you are suffering from vibration white finger as a result of your work, you may be entitled to compensation.. Vibration white finger can result in horrible symptoms, including constant pain in that hands which hugely reduce your quality of life, and it can stop you working for good in the job that you love. If youre worried about the financial implications of vibration white finger, you shouldnt hesitate to make a vibration white finger claim for compensation.. Your employer has a duty to protect you from injuries such as VWF and should have trained you accordingly to make you aware of the dangers and threats that are posed in these situations. If they have failed to do so, then they become liable for compensation claims against them.. If you have not been protected from VWF then Contact ...
Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ) (costs for program #151501) ✔ University Hospital Münster ✔ Department of Gerneral Internal Medicine, Nephrology, Hypertension Diseases and Rheumatology (Medical Department D) ✔ BookingHealth.com
Diagnosis of raynauds syndrome (Raynaud disease ) (costs for program #225393) ✔ University Hospital Würzburg ✔ Department of Pediatric and Adolescent Medicine ✔ BookingHealth.com
Considering a prevalence of 5-10% in the general population, there is still a place and probably a need for the development of new treatment concepts. Ginkgo biloba has shown to have anti-oxidative and anti-platelet activities. In a small placebo controlled trial in patients with the Raynaud´s phenomenon promising results for the Ginkgo biloba extract were shown. EGb 761® is known to be safe and well tolerated. Based on the above considerations, EGb 761® may be an effective treatment for Raynaud´s phenomenon.. Aim: To determine the efficacy and safety of EGb 761® in patients with Raynaud´s phenomenon on the frequency, duration, and severity of vasospastic attacks compared to placebo. ...
It is well known that the angiographic no-reflow phenomenon occurs after intervention in degenerated saphenous vein grafts. In these cases, distal embolization of plaque or thrombus from the lesion site is the likely mechanism.11,12⇓ Webb et al13 reported the presence of particulate material in 21 of 23 distal protection device procedures, in which pathological examination revealed the presence of particles with a necrotic core of cholesterol clefts, lipid-rich macrophages, and fibrins.. In patients with AMI, Sutsch et al14 have reported that plaque debris consisting of a necrotic core, inflammatory cells, cholesterol debris, and old and fresh thrombi are often retrieved from the distal portions of infarct-related arteries after direct angioplasty.. In the present study, we demonstrate that the angiographic no-reflow phenomenon after primary angioplasty or stenting in patients with AMI correlates with lesion IVUS morphology. The morphological features of the lipid pool-like image are similar ...
Background: It was reported that patients with acute coronary syndrome (ACS) frequently have vulnerable plaques in the remote coronary arteries, suggesting ACS is a part of the pan-coronary process and systemic inflammation. MDCT allows us to assess not only culprit lesion but also whole coronary trees. However in patients with ACS, the impact of plaque morphology in remote coronary arteries and C-reactive protein (CRP) on the occurrence of slow flow phenomenon (SF) during PCI is still unclear.. Methods: Consecutive 116 patients (69±9 years, 78% males) with acute coronary syndrome diagnosed by 128-slice dual source MDCT before coronary interventions were enrolled. Non-culprit lesions were defined as plaques with more than 25% diameter stenosis measured by quantitative angiography that had not been treated. The CT value of plaque and plaque morphology in culprit and non-culprit lesions and serum CRP level were compared between patients with and without SF during PCI.. Results: Thirty six ...
The current study is the first to demonstrate significant associations between unfavorable fibrin clot properties and the no-reflow phenomenon observed in STEMI patients after primary angioplasty. We have found that in patients with impaired both epicardial and myocardial reperfusion fibrin clots are composed of more dense fibrin networks, which are more resistant to lysis compared with those in individuals with a complete reperfusion. This finding suggests that altered clot properties may characterize patients with the no-reflow phenomenon and might help identify subjects at increased risk of such a complication.. There are reports suggesting a role of platelet-fibrin thrombus in the no-reflow phenomenon. It has been shown that fragmented thrombus and ruptured plaque released from a culprit lesion during thrombolysis or primary angioplasty led to the embolization and peripheral microvascular obstruction which can be detected in above 15% of patients. Distal embolization showed associations with ...
VWF or Vibration white finger is usually associated as HAVS or Hand Arm Vibration Syndrome. The term used was Vibration White Finger just before it was recognized that there were several symptoms connected to the case than just merely acquiring white fingers.
At present it seems likely that the different components of the hand-arm vibration syndrome, eg, vibration-induced white finger (VWF), numbing of the hands and arms, muscular fatigue, and occasionally prevalent bone degeneration, may arise independently, and therefore they should be evaluated separately. Evidence of changes caused in the autonomic nervous functions of the body by local vibration is not conclusive. The vascular history should be confirmed objectively with a cold provocation test under laboratory conditions. In individual diagnostics it is useful to record (with modern plethysmographic techniques) the recovery of digital temperature, digital blood pressure, and flow after local cooling. Vibrotactile perception measurement seems to be suitable for group diagnosis. Much of the diagnostic weight for VWF can be obtained from accurate case histories, although, for early changes, the history may be atypical. The lack of simple objective tests for evaluating the hand-arm vibration ...
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Monday, October 1, 2012 Vibration-induced white finger disease (VWF) is caused by continued use of vibrating hand held machinery (high frequency vibration ,50 Hz), and affects tens of thousands of people. New research published in BioMed Centrals open access journal Clinical Epigenetics finds that people with a genetic polymorphism (A2191G) in sirtuin1 (SIRT1), a protein involved in the regulation of endothelial NOS (eNOS), are more likely to suffer from vibration-induced white finger disease.. VWF (also known as hand arm vibration syndrome (HAVS)) is a secondary form of Raynauds disease involving the blood vessels and nerves of arms, fingers and hands. Affected fingers feel stiff and cold and loose sensation for the duration of the attack, which can be very painful. Loss of sensation can make it difficult to carry out manual activities. Initially attacks are triggered by cold temperatures but as the disease progresses attacks can occur at any time.. Little is known about what causes the ...
There has been substantial controversy regarding the use of spinal cord stimulation in ischemic extremity disease. However, current information favors the use of this treatment in inoperable ischemic extremity disease. There have been a large number of prospective studies, as well as a systematic Cochrane Review, indicating the appropriateness of spinal cord stimulation in this scenario.5 However, the studies focus primarily on atherosclerotic vascular disease. Although the exact mechanism of action of spinal cord stimulation in ischemic extremity disease is still uncertain, it most certainly affects peripheral vasoconstriction and therefore should be effective in vasospastic disease, such as Raynauds Disease ...
The reference homoeopathic remedy to treat Raynauds syndrome is Secale cornutum 5 CH. This remedy is effective against blood circulation disorders, and for the treatment of frostbite that affects the face, hands and feet. It helps to relieve cold sensations and feelings of numbness that may eventually be accompanied by cramps. It is also advisable to take Secale cornutum 5 CH during 4 months, the dosage consisting of 5 granules to be taken in the morning and evening outside of meals, leaving them to dissolve under the tongue. It is also possible to administer Secale cornutum to babies by diluting the remedy in a bit of water. Intakes of Secale cornutum, Camphora 5 CH and Sepia officinalis may also be prescribed, although they will need to be rotated in three daily intakes, each of which will consist of a 3-granule dose.. Several other homoeopathic remedies for treating Raynauds syndrome exist. For example, a 4-granule dose of Pulsatilla 5 CH taken twice a day is very effective against ...
The underlying mechanisms behind the effect of atorvastatin on patients with coronary slow flow (CSF) remain largely unknown. To investigate the possible underlying molecular mechanisms 108 patients were divided into atorvastatin group and control group. Coronary flow was quantified according to corrected TIMI frame count (CTFC). Serum high sensitivity C-reactive protein (hs-CRP), lipids, ET-1, interleukin (IL)-6, NO, circulating endothelial progenitor cell (cEPC) count, adhesion, migration and proliferation were measured in pretreatment and post-treatment. After respective treatment, the atorvastatin group had significantly decreased levels of TC, TG, LDL-C, hs-CRP, ET-1 and IL-6 and increased NO compared to the control group. The atorvastatin group had a more significant improvement of CTFC, effective rate, cEPC number, EPC adhesion, migration and proliferation compared to the control group. In conclusion, atorvastatin can be used in treatment of CSF by suppressing inflammation and improving ...
This is a photo of a finger ulcer caused by secondary Raynauds phenomenon in a patient with mixed connective tissue disease (MCTD). The MCTD developed after thyroidectomy.
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ABSTRACT In a study of vibration-induced white finger (VWF) 39 chain saw operators, being representative of 365 lumberjacks according to a completed questionnaire, underwent clinical investigation. In a medical interview 13 of the 39 had VWF and 26 were without finger symptoms. In the subjects with VWF both hands were equally affected, the third and fourth finger most frequently; the thumbs were always normal. A cold provocation test, measuring the finger systolic blood pressure with a cuff technique during combined body cooling and finger cooling to 30, 15, and 6°C, was applied to the 39 chain saw operators and to 20 age-matched outdoor workers who had not used vibrating hand tools. The finger most often showing Raynauds phenomenon was cold provoked, and a non-affected finger was used as a reference. The systolic pressure gradient measured at 30°C from the upper arm to the cooled finger was increased in the chain sawyers most severely affected by VWF compared with the control group and with ...
BACKGROUND: NOS inhibitors are a potential treatment for patients with cardiogenic shock during acute myocardial infarction. Despite hemodynamic efficacy, their effects on the extent of myocardial infarction (MI) and the no-reflow phenomenon (NRP) ha
Electron and light microscopic studies were performed on rabbit brain to re-examine the structural changes of endothelial cells and perivascular glia following ischemia. Although swelling of perivascular glia occurred, earlier findings of extreme perivascular glial swelling and bleb formation leading to luminal collapse and plugging could not be confirmed. Ischemic brains, however, had a higher proportion of small-diameter capillaries than controls. It is felt that structural changes in ischemic capillary walls in themselves are not sufficient to explain failed cerebral reperfusion, or the no-reflow phenomenon. ...
Results An adolescent girl, aged 11 years, presented herself 6 weeks after developing Raynauds phenomenon on fingers, toes and her tongue at our consultation (image 1). This symptom appeared typically after sudden change of temperature or in stressful situations. She didnt describe pain, only a fizzy sensation on the tongue. After some minutes, the coloration went back to normal. Physical examination revealed a heliotrope rash on the face and arthritis of 10 joints. In the first place, blood exams were performed, suspecting connective tissue disease. These tests revealed high level of anti-nuclear-antibodies (ANA ,5120 U/ml) and presence of anti-RNP 68 (,100U/ml) and anti-U1-RNP (,100U/ml) but no sign of inflammation. The capillaroscopy did not show any signs of desertification or megacapillaries. In the first place, Hydroxychloroquine was introduced as patient had only few complaints. As articular condition got worse, Prednisone and Methotrexate were introduced with resolution of the ...
Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed connective tissue diseases mean in law?
Editor,-Studies on visual field and peripheral circulation had led to the hypothesis that the eye might be involved in the vasospastic syndrome,1 a potential contributor to glaucomatous optic neuropathy.2 In some patients with peripheral vasospasms, visual field defects worsened after cold provocation, and, often, both peripheral vasospasms and visual field defects improved after calcium channel blocker treatment.1Because these and newer observations3 suggest some parallels in ocular and digital blood flow regulation, the relation between ophthalmic artery and nailfold capillary blood flow velocities was evaluated.. Fifty patients with primary open angle glaucoma with a mean age of 67 (SD 15) years were examined. Excluded were patients with previous filtering surgery or systemic and cardiovascular diseases. Blood flow velocity in nailfold capillaries was assessed in one randomly chosen finger of the right hand (totally arbitrary choice) by means of nailfold capillaroscopy.4 The velocities ...
Hand-Arm Vibration Syndrome, or HAVS results from the repeated use of many different kinds of handheld tools and can cause those that suffer from it significant pain and disability in the long-term. You may have HAVS as a result of your work in a trade or profession. You may have used pneumatic drills, jackhammers or air/compressor tools. You may have developed pain, numbness and tingling in your hands and fingers. You may have been screened by your current employer and told you have HAVS. It may be possible to claim against your current or former employers. Jackson Boyd has significant experience in helping individuals claim compensation for HAVS.. If you suffer from HAVS and think you deserve compensation, you will normally have only three years to bring a claim, so it is important to act quickly. To minimise the stress you experience at this difficult time and to give you extra peace of mind, we offer a free initial consultation and operate on a no-win, no-fee basis. To talk to a person who ...
Monitoring your blood pressure at home used to be a rather tricky prospect for many people. Those who had arthritis couldnt squeeze the bulb used to pump up the pressure cuff, and those with hearing loss couldnt hear the heart sounds through the stethoscope. Even those with no physical problems had to learn the proper rate of cuff deflation and how to distinguish subtle heart sounds. Today, however, all of those problems have been solved by the development of digital monitors.. If youre using a fully automatic digital blood pressure monitor, all you have to do is position it on your arm and push a button. The cuff inflates and deflates automatically at the proper rate. Since the blood pressure is measured by an oscilloscope, theres no need to listen for heart sounds. The systolic and diastolic numbers are displayed on a small screen. Pulse rate is usually displayed as well. A semiautomatic digital monitor does everything except inflate the pressure cuff. Digital blood pressure monitors are ...
Ozeri BP01K CardioTech Pro Series Digital Blood Pressure Monitor with Heart Health and Hypertension Indicator is perfect for tracking your blood pressure! I love that Ozeri BP01K Digital Blood Pressure Monitor stores 180 blood pressure readings so I can look back and see whether my high blood pressure is improving. I also love how easy to read the screen is. The numbers are large and the range indicator is also very easy to understand and read. This is a terrific way to track your blood pressure readings and Ive tested the readings with another monitor that I have and can confirm that they are accurate ...
TY - GEN. T1 - Computer simulation of flow phenomena in distensible arterial bifurcation models. AU - Perktold, Karl. AU - Peter, Reinfried Odo. AU - Gürtl, Raimund. PY - 1992. Y1 - 1992. M3 - Conference contribution. SN - 88-7958-001-9. SP - 377. EP - 381. BT - Proceedings - MEDICON. PB - CNR. CY - Pisa. ER - ...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue diseases. These diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. (For more information on these disorders, see the Related Disorders section of this report.). A condition known as Raynauds phenomenon may precede the development of additional symptoms of MCTD. Raynauds phenomenon, which is seen also in scleroderma, is characterized by painfully cold fingers and toes with blue and/or white color changes caused by spasm of blood vessels in the hands and feet in response to cold or stress. It occurs in approximately 90 percent of individuals with MCTD.. Pain in multiple joints (polyarthralgia) or inflammation of joints (arthritis) also occurs in the majority of affected individuals. Lupus-like skin inflammation in sun-exposed areas and hair loss are common, as are skin scarring changes on the fingers and face like those seen in ...
We report a case of 62-year-old Tunisian woman with a 10-year history of a CREST syndrome (systemic sclerosis meeting the criteria of the CREST syndrome of the 1980 American College of Rheumatology classification for raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Her daughter is treated in neurology for myasthenia gravis. Our patient presents a 5-month history of increasing inflammatory right thumb pain concomitant with the discovery of a subcutaneous hard mass (A). Radiographs of her thumb showed a sub-cutaneous calcification (as another part of the CREST syndrome criteria) (B). X-rays of hands found an acro-osteolysis (C). In the CREST syndrome, the calcific deposits can be subclinical. But, when symptomatic, it becomes painful, tender and an inflammatory reaction can occur facing the calcinosis.
Methods and results In 90-min ischaemia and 3-h reperfusion model, Minipigs were randomly assigned to four groups (n=8 in each group): (1) Sham; (2) Control; (3) TXL: 0.05 g·kg−1 of TXL was gavaged 1 h prior myocardial ischaemia; (4) TXL+H-89 (1.0 μg·kg−1·min−1, an inhibitor of PKA). TXL significantly decreased creatine kinase (CK) activity, reduced the infarct size from 78.5% to 59.2% and no-reflow area from 48.6% to 9.5% (p,0.05), while H-89 completely abolished the reduction of CK activity and necrosis size, and partially diminished the reduction of no-reflow size. TXL enhanced the PKA activity in ischaemic myocardium, increased the expression of PKA, Thr 198 p-PKA and Ser 635 p-eNOS in no-reflow area, and upregulated the expression of eNOS and Ser 1179 p-eNOS in reflow area. H-89 repressed the enhancement of PKA activity and the upregulation of eNOS and Ser 635 p-eNOS, but without great inhibition on the expression of PKA and Thr 198 p-PKA in no-reflow area, and even stimulated the ...
Results In observation group patients with dSSc had higher frequency of pulmonary hypertension (28.6% vs. 12.0% in lSSc patients and vs. 10% patient with CREST). Lung involvement control by diffuse capacity of CO (DLCO) was 85.7% in dSSc vs. to 66.2% in lSSc, although fibrosis detected by CT was similar. Activity score was higher in patients with dSSc (4.41), vs 2.33 in patients with lSSc, 2.5 in patient with CREST. Skin score mRodnan was higher than 14 in 87.5% in patients with dSSc, to 16.7% in patients with lSSc and 40% in patients with CREST. Visual analogue scales in presence of Raynaud phenomenon, pulmonary involvement, involvement of gastrointestinal tract, activity of SSc were higher in patients with dSSc. SSc HAQ score was a little bit higher in patients with dSSc (1,6) and CREST (1.67) to lSSc (1.43). Antinuclear antibodies (Hep2) were positive in 86.2% patients, autoantibodies to anti-DNA topoisomerase were in 33.8% and anti-centromere autoantibodies in 9.2% patients. In all patients ...
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses endothelial dysfunction and oxidative stress associated with the metabolic syndrome. Delphine, Behr-Roussel; Oudot, Alexandra; Caisey, Stephanie; Le Coz, Olivier; Gorny, Diane; Bernabé, Jaques; Wayman, Chris; Alexandre, Laurent; Giuliano, Francois // BMC Pharmacology;2007 Supplement 1, Vol. 7, pS28 An abstract of the paper "Chronic Inhibition of Cyclic GMP Phosphodiesterase 5A Prevents and Reverses Endothelial Dysfunction and Oxidative Stress Associated With the Metabolic Syndrome," by Behr-Rousse Delphine, Alexandra Oudot, and colleagues is presented. ...
Autoimmune myositis encompasses various myositis-overlap syndromes, each being identified by the presence of serum marker autoantibodies. We describe a novel myositis-overlap syndrome in 4 patients characterized by the presence of a unique immunologic marker, autoantibodies to nuclear pore complexes. The clinical phenotype was characterized by prominent myositis in association with erosive, anti-CCP, and rheumatoid factor-positive arthritis, trigeminal neuralgia, mild interstitial lung disease, Raynaud phenomenon, and weight loss. The myositis was typically chronic, relapsing, and refractory to corticosteroids alone, but remitted with the addition of a second immuno-modulating drug. There was no clinical or laboratory evidence for liver disease. The prognosis was good with 100% long-term survival (mean follow-up 19.5 yr). By indirect immunofluorescence on HEp-2 cells, sera from all 4 patients displayed a high titer of antinuclear autoantibodies (ANA) with a distinct punctate peripheral (rim) ...
I have high blood pressure but it is controlled with medication and so I was excited about receiving the Ozeri CardioTech Pro Series BP5K Digital Blood Pressure Monitor with Voice-Guided Operation & Intelligent Hypertension Indicator to try out for myself! I really love this Blood Pressure Monitor! What I like best is that it is very accurate. Its also easy to use and I not only see my results, I can hear them as well. It can easily be used by two people in the same household since it will store readings for two individuals. Now, that is a real plus! I have tried various blood pressure monitors over the past few years and this really is my favorite so far. I really didnt find anything that I didnt like about it! It also comes in a handy plastic carrying case, which I can easily put in my purse. I highly recommend this product! It really is a must-have, especially those who have high blood pressure or those who are keeping track of their blood pressure. You can find it on Amazon and Sears. ...
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With the largest screen size in its class, Lenus® > Arm is a fully-automatic digital blood pressure monitor that delivers fast, reliable measurements of systolic and diastolic blood pressure and pulse. Lenus® > Arm is designed for the medical professional requirements in a hospital setting, but it is also easy enough for a home user to measure blood pressure in the comfort of their home. Lenus® > Arm also stores up to 120 prior measurements in 2 zones, so users can track their blood pressure readings over time. The impressive super-large screen size with big, high-contrast letters means easier viewing and usage for visually-impaired users. Just a few minutes a day can make the difference.. Intended for adult use , Batteries: 4 AA (included).. ...
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Title: Mixed Connective Tissue Disease, a Roundabout to Rheumatic Diseases?. VOLUME: 5 ISSUE: 2. Author(s):Silvia Bellando-Randone, Maurizio Cutolo, Laszlo Czirjak and Marco Matucci-Cerinic. Affiliation:Department of Biomedicine, Division of Rheumatology AOUC, DENOThe Center, University of Florence, Villa Monna Tessa, Viale Pieraccini 18, 50139, Firenze, Italy.. Keywords:MCTD, capillaroscopy, therapy, systemic sclerosis. Abstract: Introduction: Mixed Connective Tissue Disease (MCTD) has originally been described as a syndrome that consisted of a combination of features typically found in patients with Systemic lupus erythematosus (SLE), Systemic Sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), or rheumatoid arthritis (RA). Objective: The diagnosis of MCTD still remains controversial and it is critically dependent on the demonstration of high-titer anti-U1-RNP antibodies. When first described, MCTD, was believed to have a good prognosis. After longer follow-up studies this opinion has now ...
Objective: SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] might function as a novel platelet-endothelial adhesion molecule and play pathological roles in cardiovascular biology. Acute myocardial infarction is one of the most common causes of death in modern society. The concept of no reflow (NR) refers to a state of myocardial tissue hypoperfusion in the presence of a patent epicardial coronary artery. The main mechanisms of this phenomenon are thought to be high platelet activity and much thrombus burden. So, we researched the role of SCUBE1 in the pathogenesis of NR ...
A 41 year old male hypertensive smoker presented with acute abdominal pain and transient widespread ST elevation on the ECG. Coronary angiography (panel A) revealed a mobile opacity in the proximal left main stem (arrow) and a slow flow phenomenon in the left anterior descending artery. Treatment was given with aspirin, clopidogrel, low molecular weight heparin and a tirofiban infusion over three days. Repeat angiography showed identical appearances in the left main stem with normal flow in the left anterior descending artery. Intravascular ultrasound of the left main stem (panel B) showed a non-occlusive atherosclerotic plaque (X) with adherent thrombus (Y). An attempt to aspirate the thrombus using the Rescue thrombosis management system failed. The lesion was therefore treated with stenting using a 4.5 × 13 mm Ultra bare metal stent, post-dilated to 5 mm (panels C and D). The patient made an uneventful recovery. Repeat angiography is planned at four months.. ...
The symptoms of Raynauds phenomenon, arthralgia, and dysphagia point toward the diagnosis of scleroderma. Scleroderma, or systemic sclerosis, is characterized by a systemic vasculopathy of small and medium-sized vessels, excessive collagen deposition in tissues, and an abnormal immune system. It is an uncommon multisystem disease affecting women more often than men. There are two variants of scleroderma ;a relatively benign type called the CREST syndrome "C-calcinosis.R- raynaud phen. E- esophagal dysmotility.S-sclerodactyly.T-talangiectasia" and a more severe, diffuse disease ...
Boob Scoop: When a baby breastfeeds, she can comfort suck after a feeding to help herself settle. However, with a bottle she may appear to still be hungry when all she really needs is more sucking time. A slow flow bottle nipple helps with this because it offers the baby an opportunity for additional sucking time and a chance for the baby to realize that she is full. A slow flow bottle can be particularly helpful when a baby is in daycare: a mom may begin to doubt her milk supply if her baby is drinking more than the she is pumping at work. But it may not be that the baby needs more breastmilk in the bottle but rather that she needs more sucking time. Besides using a slow flow bottle nipple, a pacifier or other soothing methods, like being carried in a sling or carrier, can help a baby to settle after a feeding.. Sharen Medrano, Yummy Mummy Support Group IBCLC (www.nycbreastfeeding.com) ...
During the initial development of microvascular tissue transfer techniques, several vasodilating agents first used with axial flaps for salvage or "pharmacologic delay"44,45 (i.e., attempting pharmacologically to induce resistance to acute ischemia), were used for similar purposes in free tissue transfer.9 Use of these drugs (e.g., isoxuprine) has decreased with increasing experience with microsurgical procedures. Evidence has accumulated demonstrating that success in uncomplicated procedures does not depend on the use of systemic vasodilators. 30,31 Experience with tissues subjected to trauma and prolonged or repeated ischemia, as in cases of multiple anastomotic revisions, led to recognition of the "no-reflow phenomenon" as a microsurgical complication.10 This phenomenon had been reported earlier in ischemic organ transplants. Functionally, the no-reflow phenomenon is a state in which the microcirculation distal to a microvascular arterial anastamosis no longer functions as a patent bed. ...
Eosinophilic fasciitis (/ˌiːəˌsɪnəˈfɪlɪk ˌfæʃiˈaɪtɪs, ˌiːoʊ-, -ˌfæsi-/), also known as "Shulmans syndrome", is a form of fasciitis, the inflammatory diseases that affect the fascia, the connective tissues surrounding muscles, blood vessels and nerves. Unlike other diseases in that category, it is limited to the arms and legs, and usually resolves itself, although some cases require corticosteroids, and some cases are associated with aplastic anemia. The presentation of eosinophilic fasciitis is similar to scleroderma or systemic sclerosis. However, unlike scleroderma, it affects the fascia, not the skin (dermis). The characteristic and severe effects of scleroderma and systemic sclerosis, such as Raynauds syndrome, involvement of the extremities, prominent small blood vessels (telangiectasia), and visceral changes such as swallowing problems, are absent. It was first characterized in 1974, and it is not yet known whether it is actually a distinct condition or just a ...
Discussion. Hypoxia may influence MPV levels. Ghahremanfard et al. associated9 MPV levels with first acute ischemic stroke severity grading (p=0.012). Isik et al. correlated10 the MPV levels ranged from 6.5fL to 11.7fL, with slow coronary flow (p=0.03). Balcik et al. measured11 MPV values significantly higher at 24h after progression of ischemic stroke (p=0.001) than control participants. Damaske et al. indicated12 increased MPV levels in slow coronary flow phenomenon than control ones. Ertaş et al. observed13 an increase in MPV levels in chronic heart failure as an independent predictor of mortality than (p=0.004) in control group. Açikgöz et al. noted14 significantly higher MPV values in ischemic cardiomyopathies than control ones (p,0.001). Ntaios et al. related15 the significantly increased MPV levels in acute ischemic non-lacunar stroke with poor functional outcome 24h after. Slavka et al. indicated16 that an increased MPV value (≥11.01fL) creates higher risk for ischemic heart ...
Chondrodermatitis nodularis chronica helicis is a rare non-neoplastic inflammatory and degenerative process of the external ear, characterized by necrobiotic changes in the dermis that extend down to the perichondrium. This condition has been occasionally reported in patients with limited cutaneous systemic sclerosis but not in those with concomitant primary biliary cirrhosis; this association is known as Reynolds syndrome. We report a 70-year-old woman diagnosed with primary biliary cirrhosis at age 47 and with limited cutaneous systemic sclerosis at age 54 who developed a painful ulcerated nodule on the helical rim of the left ear shortly after the last diagnosis. Read More ...
This book focuses exclusively on ergonomics in the design and use of hand tools. Hand tools have been an integral supplement to the human hand since the beginning of civilization. Recently, they have been pinpointed as a prominent cause of workplace disease. Cumulative Trauma Disorders such as Tendonitus, Carpal Tunnel Syndrome, and Raynauds Syndrome are caused by the specialization of motion employed when using a screw driver, the shock to the hand and wrist when a hammer strikes a nail, or the vibration of a power saw. Ergonomics and Safety in Hand Tool Design explores the relationship between Biomechanics, Safety, and Ergonomics allowing the reader to recognize, evaluate, and control ergonomic risk factors and improve hand tool design.After a history of hand tool use and design, the book is broken down by the various disciplines as they apply to hand tools, taking a broad approach. The author gives special attention to safe design and use, illustrated with detailed diagrams. The text serves as a
Thoracic Outlet Syndrome (TOS) refers to an ill-defined assortment of disorders originating in the passageway between the neck and chest - called the thoracic outlet. These disorders arise from the crowded nature of the thoracic outlet, which is an expressway for the throat, trachea, major blood vessels and many nerves. TOS commonly shows itself as pain, swelling or a "pins and needles" sensation in the hands, shoulders and arms. Similar discomforts can occur in other parts of the upper body including the chest, neck, head and ears. At the root of all TOS problems is pressure or compression on nerves or blood vessels passing through the thoracic outlet. The particular nerves and blood vessels compressed are usually the nerves of the branchial plexus and the subclavian artery or vein. Sometimes the pressure is severe enough to cause Raynauds Syndrome, in which the fingers turn white when in the cold. Severe TOS also has been known to result in gangrene in the fingers. ...
In 1959 Myron Prinzmetal first described variant angina. Without the aid of selective coronary angiography he attributed the syndrome to the "temporary occlusion of a large diseased artery with a narrow lumen due to a normal increase in the tonus of the vessel wall.". A 66 year old woman who had been smoking 15 cigarettes each day for 50 years and who had a long history of Raynauds syndrome presented with an episode of severe chest pain associated with pronounced ST elevation in the inferior and lateral leads (left). She was enrolled in a thrombolytic trial that involved the performance of early coronary angiography. Ninety minutes after receiving 100 mg of tissue plasminogen activator the ST segments were still elevated. Coronary angiography of the right coronary artery showed a discrete 90% stenosis that resolved following 200 μg of intracoronary nitroglycerin (top). An ECG recorded 30 minutes later demonstrated complete resolution of the ST segments (bottom). There was no subsequent enzyme ...
A sympathetic nerve block may be used to diagnose or treat a patient who suffers from chronic nerve-related pain, including pain associated with amputation, spasms in the blood vessels after frostbite, chronic tail bone pain (coccydynia), shingles, complex regional pain syndrome/reflex sympathetic dystrophy and Raynauds syndrome.
Patients with mixed connective tissue disease (MCTD) exhibit clinical features of systemic lupus erythematosus (SLE), progressive systemic sclerosis or scleroderma (PSS), and polymyositis-dermatomyositis (PM-DM). In their sera is an unusually high ti
Capillaroscopy is a method used to examine a patients microcirculation and assess pathological changes. It is completely safe and noninvasive. Using some sort of microscopy, the clinician looks through the epidermis of the nailfold to view the capillaries of the distal papillae.3. Ariane Herrick, MD, is professor of rheumatology at the University of Manchester and honorary consultant rheumatologist at Salford Royal NHS Foundation Trust, England. She explains that nailfold anatomy makes it an ideal place to evaluate the microcirculation. In most of the skin, capillaries run perpendicular to the skin surface, and only the tip of the loop is visible.. Dr. Herrick explains, "At the nailfold, capillaries run parallel, rather than perpendicular, to the skin surface, and they can, therefore, be visualized noninvasively when magnified. Capillaries themselves are invisible, but what can be seen is the column of red blood cells within the capillaries.". This is of interest to rheumatologists in ...
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This report describes the main features of the results obtained in the course of this project. A new approach to the systematic development of closure relations for the averaged equations of disperse multiphase flow is outlined. The focus of the project is on spatially non-uniform systems and several aspects in which such systems differ from uniform ones are described. Then, the procedure used in deriving the closure relations is given and some explicit results shown. The report also contains a list of publications supported by this grant and a list of the persons involved in the work.
Electrostatic precipitators (ESPs) are now being tasked with simultaneously removing particulate matter (PM) and trace gas-phase pollutants such as mercury released during coal combustion. This represents a significant expansion of their original operational mission, one which is not captured by decades old quasi-1-D analytical expressions developed from first principles for predicting PM removal alone. At the same time, technological advances in ESP power supplies have led to steady increases over the years in the applied voltage achievable in new or refurbished ESPs. In light of these industry trends, the present study extends our previous study to examine the multiphase flow phenomena that may occur during such ESP operations, specifically the effects of electrohydrodynamic (EHD) fluid flow phenomena that can emerge when electrical current densities are high and/or fluid velocities are low. The results show good agreement at low current densities between the present ...
NASCIF, Ana K. S. et al. Inflammatory myopathies in childhood: correlation between nailfold capillaroscopy findings and clinical and laboratory data. J. Pediatr. (Rio J.) [online]. 2006, vol.82, n.1, pp.40-45. ISSN 0021-7557. http://dx.doi.org/10.2223/JPED.1435.. OBJECTIVE: Nailfold capillaroscopy is an important tool for the diagnosis and follow-up of patients with rheumatic diseases, in particular dermatomyositis and scleroderma. A relationship has been observed in adults between improved capillaroscopic findings and reduced disease activity. Our aim was to correlate disease activity (clinical and laboratory data) and nailfold capillaroscopy findings in 18 patients with inflammatory myopathies. METHODS: This prospective study included 13 juvenile dermatomyositis patients (Bohan and Peter criteria) (mean age of 8.8 years) and five patients with overlap syndrome (mean age of 15.7 years). We evaluated disease activity (skin abnormalities and muscle weakness, muscle enzymes and acute phase ...
In patients with systemic sclerosis (scleroderma), the lung is commonly involved, and lung disease is now the most common cause of scleroderma-related morbidity and mortality. Scleroderma is suggested by the typical skin findings. Pigment changes appear first, followed by skin thickening, digital pitting, and ulceration. Skin changes can extend proximally; patients with skin findings proximal to the elbows have diffuse scleroderma, as does this patient. In patients with scleroderma, both interstitial lung disease and pulmonary hypertension can develop (either independently or together) and have an adverse impact on outcome. Pulmonary disease can also be the initial clinical manifestation of scleroderma and is most commonly associated with diffuse scleroderma. Pulmonary hypertension is more commonly associated with limited scleroderma (CREST syndrome: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia). A comprehensive history and physical examination are ...
Hello, I have Raynauds and a tentative diagnosis of limited cutaneous systemic sclerosis. I could not tolerate nifedipine; I can tolerate losartan potassium but it does not seem to offer any symptom...
Mixed connective tissue disease (MTCD) is a rare connective tissue disorder. MCTD is used to describe what may be an overlapping group of connective tissue disorders that cannot be diagnosed in more specific terms. These disorders include systemic lupus erythematosus, polymyositis, and scleroderma. Individuals with MCTD...
A mixture of three diseases of connective tissue (the framework of the cells of the body) systemic lupus erythematosus, scleroderma, and polymyositis. Patients with mixed connective tissue disease typically have features of each of the three…
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Detection of diseases in an early stage is very important since it can make the treatment of patients easier, safer and more ecient. For the detection of rheumatic diseases, and even prediction of tendencies towards such diseases, capillaroscopy is becoming an increasingly recognized method. Nail-fold capillaroscopy is a non-invasive imaging technique that is used for analysis of microcirculation abnormalities that may lead todisease like systematic sclerosis, Reynauds phenomenon and others.. The main goal of this master thesis project is to provide new tools and techniques for the analysis of capillaroscopy images from the nail-fold area. Image processing and machine learning techniques are applied to images obtained by digital microscopes, like Mediscope as produced by Optilia Instruments AB, Sollentuna. This thesis oers a novel way for segmentation of capillaries from images as well as (semi)automatic capillary width calculation and automatic annotation of capillaries. These tools provide new ...
Transcriptional activity of tumor necrosis factor-alpha gene in peripheral blood mononuclear cells in patients with coronary slow flow
A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Diffuse cutaneous systemic sclerosis
Test for mixed connective tissue disease, an autoimmune disease often referred to as overlap syndrome. RNP antibodies found in 95-100% MCTD patients
Fatal pancreatic necrosis, secondary to extensive acute arteritic changes, is reported in a case of progressive systemic sclerosis. The patient presented first with hypertension and renal involvement, with active vascular lesions demonstrated by biopsy. The renal lesion at necropsy was inactive, showing the characteristic concentric fibrosis only, while the pancreatic vascular lesions were both chronic proliferative and acute in type. ...
The presence of no-reflow in patients with acute myocardial infarction has been found to be a predictor of adverse events, with higher incidence of left ventricular (LV) remodelling, congestive heart failure, and death. An initial study by Wu et al. (n. 44; follow-up 16 months) demonstrated that patients with MVO had more cardiovascular events (45% versus 9%, P 0.016) independently of the total infarct size (6). Since then, several studies have succeeded in demonstrating such a correlation. A larger study by Hombach et al. (20) found that infarct size, MVO, LV end-diastolic volume, and EF predicted major adverse cardiac events (MACE), with MVO being the strongest predictor (13.2% more events). Cochet et al (21) showed that MVO and the Global Registry of Acute Coronary Events (GRACE) score were significant predictors of MACE (odds ratio [OR], 8.7; CI, 3.6 to 21.1; P,0.001; OR, 2.8; CI, 1.3 to 6; P,0.01, respectively). Nijveldt et al. (22) examined the relation between angiographic, ...
Introduction: The association of autoimmune diseases in the same individual is common. It is well documented that Graves disease (GD) is associated to various autoimmune diseases, including: pernicious anemia, vitiligo, type 1 diabetes, Addison s disease, systemic sclerosis, myasthenia gravis, Sjogren s syndrome, rheumatoid arthritis and systemic lupus erythematosus. In addition, primary biliary cirrhosis (PBC) may be associated with rheumatoid arthritis, Sjogren s syndrome, Raynaud s phenomenon and autoimmune thyroiditis, often observed the presence of hypothyroidism. However, the association of PBC and GD is rare. It is described in the literature only 5 cases.. Case report: Female, 63 years old, sent to the endocrinologist for hyperthyroidism. The patient had a history of cholecystectomy and PBC diagnosed 9 years ago. She was treated with ursodeoxycholic acid 500 mg twice a day. She reported palpitations, excessive sweating, irritability and weight loss.. Physical examination: heart rate of ...
OBJECTIVE: To assess the prevalence and clinical and immunological significance of anticentromere antibodies (ACA) in patients with primary Sjögrens syndrome (pSS). METHODS: We retrospectively investigated the prevalence of ACA in patients with SS. We compared ACA-positive SS patients with ACA-negative pSS patients. RESULTS: The prevalence of ACA among patients with pSS was 4.7% (10/212). Among the patients with SS and an associated autoimmune disease, 10 patients had ACA and limited cutaneous sclerosis (SSc). Clinical and immunological patterns did not differ between the 10 pSS patients with ACA alone and the 10 SS patients with ACA and SSc, except for presence of limited cutaneous SSc (lcSSc). Moreover, all ACA-positive sera recognized centromere protein-B on ELISA, regardless of the presence of SSc. The entire SS-ACA group (n = 20) showed greater frequency of Raynauds phenomenon, objective xerophthalmia, peripheral neuropathy, and additional autoimmune disorders, especially primary biliary ...
ii) Ophthalmological exclusion criteria: diabetic retinopathy, infections (e.g. keratitis, conjunctivitis, uveitis), severe dry eyes, miotic drug, amblyopia, squint, nystagmus, albinism, any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields, disc imaging or accurate IOP readings, keratoconus, intraocular surgery (except for uncomplicated cataract surgery) performed , 3 month prior to screening, history or signs of any visual pathway affection other than glaucoma, allergies with regard to topic glaucoma medication, history or presence of macular disease and / or macular edema, ocular trauma.. - Normal subjects. (i) General exclusion criteria: mental or neurological diseases, diabetes mellitus, history of coronary heart disease, stroke, migraine, vasospasm / Raynaud`s disease; drugs indicating severe systemic diseases (e.g. anti-diabetic or anti-hypertensive medication for subjects under 70 years of age), drugs or medications influencing reaction time, ...
According to Dr. Raffy Castillo of the Philippine Society of Hypertension, it is paramount to have an accurate measurement of blood pressure for proper diagnosis and monitoring. "However," he states, "we consider a reading accurate only if validated Blood Pressure devices are used. Digital Blood Pressure Monitoring devices are required to be recognized by medical authorities before it is considered to be accurate and reliable enough for home use.". Omron, proudly validated and the only brand verified and accredited by the Philippine Society of Hypertension, is a healthcare brand trusted by millions of people around the globe. Omrons line of home-use products such as blood pressure monitors allow and encourage individuals of all ages to take a more hands-on role when it comes to managing their own health.. Advances in technology and years of research have made Omron digital blood pressure monitors exceedingly exact in their readings, which is why these devices have become the standard in homes ...
Currently, three phosphodiesterase type 5 (PDE5) inhibitors are available for clinical use in South Africa; sildenafil, vardenafil and tadalafil. The PDE inhibitors are used in males to treat erectile dysfunction. However, sildenafil is also registered for use in the treatment of pulmonary hypertension. Newer studies are investigating the use of these drugs for other conditions, including hypertension, ischaemia or reperfusion injury, myocardial infarction, cardiac hypertrophy, heart failure and other peripheral circulatory conditions, e.g. Raynaud's disease. The article provides a broad overview of the mechanism of action, indications, pharmacokinetics and side-effects of these agents.
Clin Orthop Relat Res. 1997 Aug;(341):12-22.. 7. Allieu Y, Marck G, Chammas M, Desbonnet P, Raynaud JP. Total elbow joint allograft for long term posttraumatic osteoarticular loss. Follow-up results at twelve years. Rev Chir Orthop Reparatrice Appar Mot. 2004 Jun;90(4):319-28.. 8. Bryan RS, Morrey BF. Extensive posterior exposure of the elbow: a triceps sparing approach. Clin Orthop. 1982; 1266:188-192.. 9. ODriscoll SW, King GJW. Treatment of instability after total elbow arthroplasty. Ortho Clin North America 2001; 32:679-695.. 10. Ramsey ML. Adams RA. Morrey BF. Instability of the elbow treated with semiconstrained total elbow arthroplasty. Journal of Bone & Joint Surgery - American 81(1):38-47, 1999 Jan.. 11. Harris WH, Schiller AL, Scholler JM, et al: Extensive localised bone resorption in the femur following total hip replacement. J Bone Joint Surg Am 1976;58:612-618.. 12. Schmalzried TP, Jasty M, Harris WH. Periprosthetic bone loss in total hip arthroplasty. Polyethylene wear debris and ...
The incidence of malignant melanoma has increased an average of four percent per year in the United States since the early 1970s.[1] Today, over one American dies every hour from melanoma.[2] Detected in its earliest stage, melanoma is almost completely curable with simple excision. However, the five-year survival rate drops to ,10 percent with stage IV disease. Therefore, the key challenge for early diagnosis is to determine which atypical pigmented skin lesions require biopsy. Technology has been shown to augment the biopsy decision accuracy of dermatologists evaluating suspicious pigmented lesions.[3]. Multi-spectral Digital Skin Lesion Analysis (MSDSLA, MELA Sciences Inc, Irvington, New York) uses narrow bands of visual and near-infrared light (430-950nm) to capture data from the skin surface down to 2.5mm in depth. At a 20-micron resolution (~diameter of 3 melanocytes), individual cellular atypia is not evaluable by MSDSLA. Instead, the device uses 75 analytical parameters to determine the ...
The answer to yesterdays mystery is … limited scleroderma (a.k.a. CREST syndrome)! Great job Priscilla, Kmu, American Girl Mommy, Erin, Rich S, guest, OB1, Phung, Shelly Langlois, mabel, vor120806, Kimberly Helton, CB, Kelly, ColorMaven, Jerry Skrocki, Amanda, Michelle, Tina M., Angelita, ER SEC, Mary, todd dombrowski, JP3, kim labounty, Dazed & Confused, JB, and PJ.. Ill give partial credit to those who named one component of CREST syndrome, Raynauds phenomenon: D2, Patti Ann, Carol, MG, Gracie287, GetAClue, Zach A., Tara Naz, Robert Jones, the other Naomi, Shannon Vincent, Martha, sallad, Michele Liguori, Veronica, Deborah Cote, JP, and GG.. CREST syndrome, or limited cutaneous systemic scleroderma, is an autoimmune disease that causes scarring of different tissues in the body, most notably the skin. The cause of the disease is unknown, but it is likely some combination of genetic factors and environmental triggers. First, inflammatory white blood cells infiltrate the skin and ...
In this collection of papers we have read about a range of research being applied to understanding the relationship between exposures to hand-transmitted vibration and injury to the hand and ann. These include laboratory studies designed to investigate specific human physiological and psychophysical responses or to determine biodynamic models for the hand and arm; animal surrogate studies to inves
I am an experienced personal injury claims solicitor specialising in particular in accidents at work. I have a great deal of litigation experience having dealt with a number of successful trials.. I joined Hodge Jones & Allen LLP from Thompsons solicitors in November 2010, having trained at Edwards Duthie. I have developed skills and experience across all types of personal injury work. My claims expertise includes cases against employers for unsafe place of work and unsafe systems of work, injuries due to lifting, tripping, work at height, faulty equipment, lack of personal protective equipment, failure to properly assess risks, failure to provide adequate training and/or supervision and violence in the workplace from colleagues and/or third parties. I have settled many highway claims for pedestrians and cyclists. I also deal with injuries sustained in a variety of public places such as shops, bars, restaurants.. I have dealt with disease cases such as vibration white finger and hearing loss, ...
The aim of this study was to assess nailfold capillaroscopic (NC) findings in patients with primary Sjögrens syndrome (PSS) with and without Raynauds phenomenon (RP) as well as in the presence of positive anti-SSA/Ro and anti-SSB/La antibodies. Videocapillaroscopy was performed in 150 patients with PSS. Data collected included demographics, presence of RP, PSS symptoms, antinuclear antibodies, rheumatoid factor, anti-Ro, anti-La, anti-CCP, salivary scintigraphy, labial biopsy, and NC findings. RP was present in 32% of PSS, keratoconjunctivitis sicca in 91%, oral xerosis in 93%, and skin or genital xerosis in 53 ...
Hypothenar hammer syndrome is characterized by vascular insufficiency of the digits. It often results from repetitive blunt trauma to the hypothenar eminence causing ulnar artery damage, likely against the hook of the hamate, resulting in arterial thrombosis or aneurysm.1,2 This rare syndrome occurs most commonly in athletes and industrial workers.3 The differential diagnosis includes other causes of digital ischemia, such as Raynauds disease, Buergers disease, atherosclerotic and embolic disease, vasculitis, and thoracic outlet syndrome.2 The gold standard for diagnosis is arterial imaging, preferably angiography, which demonstrates the classic corkscrew or aneurysmal appearance of the ulnar artery. Additionally, point of care ultrasound has been used to aid in diagnosis of this syndrome.4 Management ranges from conservative medical management to endovascular thrombolysis or surgical grafting, as in this case.2. CPC-EM Capsule. What do we already know about this clinical entity?. Hypothenar ...
The literature reports that mixed connective tissue disease seems more frequent in the black population and among Asians. This study aims to determine the prevalence of mixed connective tissue disease (MCTD) among connective tissue disorders and all rheumatologic pathologies in a hospital population in Gabon as well as to describe the clinical features of this disease. We conducted a retrospective study by reviewing the medical records of patients treated for mixed connective tissue disease (Kasukawa criteria) and other entities of connective tissue disorders (ACR criteria) in the Division of Rheumatology at the University Hospital in Libreville between January 2010 and December 2015 ...
Scleroderma esophagus is characterized by ineffective peristalsis and reduced esophageal sphincter pressure. Esophageal disease in scleroderma can precede cutaneous manifestations and has been associated with Raynauds phenomenon (RP) and pulmonary f
Chronic lupus-like illness, characterized by arthralgia, cutaneous manifestations of lupus erythematosus, and photosensitivity, occurred in two mothers of boys with chronic granulomatous disease; one mother also had Raynauds phenomenon, pleuritis, and unexplained fevers, and both had recurrent stomatitis. Both mothers were carriers with a population of defective leukocytes demonstrable in vitro. Neither had hypergammaglobulinemia or positive tests for antinuclear antibodies, lupus erythematosus cells, or rheumatoid factors. The occurrence of lupus, particularly discoid lupus, in carriers of chronic granulomatous disease has been sporadically mentioned and appears to be more frequent than would be expected from a chance occurrence. The association of lupus-like illness with this partial immune defect may be pertinent to the hypothesis that lupus erythematosus results in some way from an infectious process. ...
A sympathectomy is an irreversible procedure during which at least one sympathetic ganglion is removed. An example is endoscopic thoracic sympathectomy. INDICATIONS rest pain, ischemic ulcers, hyperhydrosis, raynauds phenomenon, causalgia, buergers disease Lumbar sympathectomy It is advised for occlusive arterial disease in which L2 and L3 ganglia along with intervening sympathetic trunk are removed leaving behind the L1 ganglion which is responsible for ejaculation ...
What exactly is connective tissue disease? Connective tissue diseases are referred to as a group of medical diseases. A connective tissue disease has a primary
A 60-year-old woman who received thrombolytic treatment for inferoposterior myocardial infarction in a peripheral hospital was referred for rescue angioplasty for ongoing chest pain. Her relevant past history included active smoking, diabetes, and reversible cerebral vasoconstrictive syndrome. At the time of myocardial infarction, she was being investigated for symptoms suggestive of possible Raynauds phenomenon. Because of administration of thrombolytic medication, a right radial artery (RA) approach for coronary angiography (CA) was decided to avoid femoral artery-related bleeding complications. Allens test was "positive" (normal), and pre-procedure, 2.5 mg of verapamil and 200 μg of glyceryl trinitrate was administered in the RA. During the procedure, the patient developed severe spasm of the RA, and the procedure was completed using 5-F guide catheters. We administered further intraradial glyceryl trinitrate and verapamil to relieve the spasm along with intravenous midazolam and fentanyl. ...
GI manifestations may be present in up to 50% of patients with SLE. Anorexia, nausea, and vomiting are among the most common. Oral ulcerations (most commonly buccal erosions) were identified in 40% of one group of patients. Esophageal involvement, as esophagitis, esophageal ulceration, or esophageal dysmotility, seems to correlate with the presence of Raynauds phenomenon. Intestinal involvement results in abdominal pain, diarrhea, and occasionally hemorrhage. Intestinal ischemia may be present and may progress to infarction and perforation. Pneumatosis intestinalis in SLE is usually benign and transient but may represent an irreversible necrotizing enterocolitis. In addition, pancreatitis and abdominal serositis are well-recognized. Abnormal liver functions also occur. A vasculitic process has been implicated in the pathogenesis of GI manifestations.. Reference: Wallace DJ: Gastrointestinal manifestations and related liver and biliary disorders. In Wallace DJ, et al (eds): Dubois Lupus ...
Systemic sclerosis is an autoimmune disease. This means that the immune system causes damage to some of the bodys own cells. Normally, our body makes proteins called antibodies to fight infections - for example, when we catch a cold or have a sore throat. These antibodies help to kill the germs causing the infection. In autoimmune diseases the body makes similar antibodies (autoantibodies) that attack its normal cells. In systemic sclerosis, the immune system damages the connective tissue cells, which are found in many parts of the body. Your connective tissue supports, binds or separates other tissues and organs within your body and can also be a kind of packing tissue in your body. So, systemic sclerosis is also classed as a connective tissue disease.. It is not known what triggers the immune system to cause systemic sclerosis. There is probably an inherited tendency to develop it. It is more common in people who have a family member with systemic sclerosis. It may be triggered by certain ...