Author: Moosmann, B. et al.; Genre: Journal Article; Published in Print: 1999; Title: The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.
Levels of inflammatory cytokines are raised in chronic obstructive pulmonary disease ( COPD). A diet rich in antioxidant vitamins may protect against the development of COPD. This study examined the effects of phenolic compounds and food sources on cytokine and antioxidant production by A549 cells. The effects of the following phenolic compounds on basal and interleukin ( IL)-1- stimulated release of IL-8, IL-6, and reduced glutathione (GSH) were examined: resveratrol; Bouvrage, a commercially available raspberry juice ( Ella Drinks Ltd., Alloa, Clacksmannanshire, UK); and quercetin 3 - sulfate. Purification of the raspberry juice by high- performance liquid chromatography gave three fractions: Fraction 1 contained phenolic acid and vitamin C, Fraction 2 contained flavonoids and ellagic acid, and Fraction 3 contained anthocyanins and ellagitannins. IL-8 production was increased in the presence of IL-1 ( 165 vs. 6,011 pg/mL, P ,.0001). None of the compounds tested had any significant effect on ...
abstractNote = {One of the main problems in Mexico and in the World is the waste water pollution of a great variety of industrial processes by organic compounds. Among those ones the phenol compounds which are highly toxic, refractories (to the chemical degradation) and poorly biodegradable. This is due in a large extent to the problem created by the accelerated increase in the environmental pollution in the cities and industrial centers. The phenol compounds are used in a great variety of industries such as the production of resins, plasticizers, antioxidants, pesticides, colourings, disinfectants, etc. These phenol compounds are specially harmful, since they have repercussions on the flora of plants of biological treatment of water affecting its operation. The main objective of this work is to evaluate the capacities of phenol detention and its derivatives in an hydrotalcite type compound and diminishing with it the presence in water, in this case, of solutions prepared in the laboratory. In ...
Introduction: Octylphenol (OP) is a degradation product of alkylphenol ethoxylates that are widely used to in rubber, pesticides and paints. Bisphenol A (BPA) is an organic compound with two functional phenol groups and used to make polycarbonate plastic and epoxy resins, along with other applications. OP and BPA are known as endocrine disruptors that can induce inappropriate estrogenic action, and may disturb natural calcium metabolism. In the present study, the effects of OP and BPA on the calcium levels of serum and urine, and calcium transport genes were investigated in the duodenum, kidney and placenta of the pregnant mice.. Methods: From 6.5 to 16.5 days after post coitus (dpc), pregnant mice were orally given with ethylestradiol (EE, 0.2 mg/kg/day), OP (15, 45, or 135 mg/kg/day) or BPA (5 or 50 mg/kg/day) dissolved in corn oil. The duodenum, kidney, placenta, blood and urine were obtained from mice at day 18.5 of pregnancy.. Results: As a result, serum and urinary calcium levels were ...
Xenoestrogens such as alkylphenols and the structurally related plastic byproduct bisphenol A have recently been shown to act potently via nongenomic signaling pathways and the membrane version of estrogen receptor-α. Though the responses to these compounds are typically measured individually, they usually contaminate organisms that already have endogenous estrogens present. Therefore, we used quantitative medium-throughput screening assays to measure the effects of physiologic estrogens in combination with these xenoestrogens. We studied the effects of low concentrations of endogenous estrogens (estradiol, estriol, and estrone) at 10 pM (representing pre-development levels), and 1 nM (representing higher cycle-dependent and pregnancy levels) in combinations with the same levels of xenoestrogens in GH3/B6/F10 pituitary cells. These levels of xenoestrogens represent extremely low contamination levels. We monitored calcium entry into cells using Fura-2 fluorescence imaging of single cells. Prolactin
[103 Pages Report] Check for Discount on United States 2-Fluorophenol Market Report 2017 report by QYResearch Group. In this report, the United States 2-Fluorophenol market is...
Exposure to toxic industrial chemicals that have capacity to disrupt the endocrine system, also known as endocrine disrupting chemicals (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among the most common environmental contaminants possessing endocrine disruption properties and are present in plastics, epoxy resins, detergents and other commercial products of common personal and industrial use. A metabolite of BPA, 4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP) is about 1000 times more biologically active compared to BPA. Epidemiological, clinical, and experimental studies have shown association of BPA and OP with adverse effects on male and female reproductive system in human and animals. The endocrine disruption activity can occur through multiple pathways including binding to steroid receptors. Androgen receptor (AR) and progesterone
Background & Objectives: Due to increase in  bacterial drug resistance, discovering new antibacterial compounds is really important. The objective of this study is to evaluate the phenol compounds effect on antibacterial activity of herbal extracts of Fasa-Fars province in vitro. Materials & Methods: The antibacterial activity of 26 plants was ...
Finnish softwood bark contains large amounts of water-soluble tannin-polyphenols, which can be used as renewable alternatives to the fossil and toxic phenol compounds widely used in glues.
Stagnant water bodies have generally received little attention regarding the presence of endocrine disruptive compounds, although they can integrate diverse pollutants from multiple different sources. Many compounds of anthropogenic as well as natural origin can contribute to the overall estrogenicity of surface waters and some of them can exhibit adverse effects on aquatic biota even in very low concentrations. This study focused on freshwater ponds and reservoirs affected by water blooms and determined the estrogenic activity of water by in vitro bioassay as well as concentrations of several important groups of estrogenic compounds (estrogenic hormones, alkylphenols, and phytoestrogens) by LC-MS/MS analyses. Estrogenic hormones were found at concentrations up to 7.1 ng.L-1, similarly to flavonoids, whose concentrations did not exceed 12.5 ng.L-1. Among alkylphenols, only bisphenol A and 4-tert-octylphenol were detected in levels reaching 100 ng.L-1 at maximum. Estrogenic activity of water ...
Is Bakuchiol a natural alternative to retinol? Ive put Boots Ingredients Bakuchiol Serum to the test to find out. Heres what happened...
Total Beauty posted Bakuchiol Is the Natural Retinol Alternative Thats Gentle on Skin featuring Dr. Purvisha Patel. The article includes Dr. Patels expert commentary on bakuchiol, a natural retinol alternative. Have you heard of bakuchiol before? Its been gaining a lot of traction lately as a natural form of retin
The delicate skin on your neck needs special attention in order to age well. Our neck cream was carefully crafted to address the look of fine lines, wrinkles and loss of firmness in thinner, more fragile skin on the jawline, neck and décolletage. In addition to Bakuchiol - a vegan retinol alternative that has been shown to be well-tolerated by the skin- this advanced neck cream also features Caffeine to minimise visible signs of ageing along with hydrating Peptides and Sustainable Edelweiss Flower Stem Cell Extract for skin the looks and feels smoother. Formulated to help improve the appearance of skin tone, texture and firmness between the chin and chest, this Bakuchiol neck cream can help all skin types appearance (including sensitive) withstand the test of time. Dermatologist-tested. , 1.7 oz. / 50 g. Mind. Body. Skin.™ Tip: Our ever-increasing reliance on (or addiction to) devices such as smartphones, tablets and laptop computers may be responsible for skin damage caused by blue light, ...
This page contains information on the chemical 2,4-Dimethyl-3-(Chloromethyl)-6-Tert-Butylphenol including: 7 synonyms/identifiers.
Ahmed S, Atlas E. 2016. Bisphenol S- and bisphenol A-induced adipogenesis of murine preadipocytes occurs through direct peroxisome proliferator activated receptor gamma activation. Int J Obes Relat Metab Disord 40(10):1566-1573, PMID: 27273607, 10.1038/ijo.2016.95. Alonso-Magdalena P, Quesada I, Nadal Á. 2015. Prenatal exposure to BPA and offspring outcomes. Dose Response 13(2):1559325815590395, PMID: 26676280, 10.1177/1559325815590395. Alonso-Magdalena P, Vieira E, Soriano S, Menes L, Burks D, Quesada I, et al. 2010. Bisphenol A exposure during pregnancy disrupts glucose homeostasis in mothers and adult male offspring. Environ Health Perspect 118(9):1243-1250, PMID: 20488778, 10.1289/ehp.1001993. Anderson OS, Peterson KE, Sanchez BN, Zhang Z, Mancuso P, Dolinoy DC. 2013. Perinatal bisphenol A exposure promotes hyperactivity, lean body composition, and hormonal responses across the murine life course. FASEB J 27(4):1784-1792, PMID: 23345456, 10.1096/fj.12-223545. Angle BM, Do RP, Ponzi D, ...
Alkylphenols are widely used industrial chemicals that act as detergents or surfactants. They are added to cosmetics, paints, pesticides, detergents and cleaning products. As a group they are highly toxic to aquatic organisms. Dozens of recent studies have documented the in-vitro and in-vivo estrogenic activity of alkylphenols in human cell lines and animals (Bechi 2006). Alkylphenols have been detected recently in surface waters contaminated with urban runoff and in wastewater effluent (Espejo 2002; Oros 2003).. Alkylphenols have been measured in air samples. One study found that newer homes, especially those with PVC materials, have more alkylphenol residues than older houses or outdoor air (Saito 2004).. ...
Provided is a styrenated phenol compound represented by Formula 1 in which styrenated phenol and hydroxylamine bind to each other: In Formula 1, n is one of integers of 1 to 3, and R 1 and R 2 are each hydrogen or one of C1 to C4 alkyl groups. The styrenated phenol compound may maintain curing stimulation property and plasticity, and prevent discoloration when being mixed with a curing agent ...
A Alkylphenol ethoxylates (APEOs) The primary biodegradability of nonionic alkylphenol ethoxylate (APEO) surfactants meets the demands imposed by environmental protection agencies. However, the intermediate products formed during biodegradation are relatively persistent and much more toxic to fish
Among the commonly reported tapentadol ER side effects are headaches, nausea, and constipation. This eMedTV page offers an overview of other possible reactions, listing common ones as well potentially serious problems that require medical treatment.
Anti-agers may have a new play in the wrinkle-reduction game. Bakuchiol was shown in a recent study to match the established benefits of retinol.
Phenol; Carbolic acid; Benzenol; Hydroxybenzene; Izal; Monohydroxybenzene; Monophenol; Oxybenzene; Phenic acid; Phenyl alcohol; Phenyl hydrate; Phenyl hydroxide; Phenylic acid; Phenylic alcohol; PhOH; Benzene, hydroxy-; Benzophenol; Acide carbolique; Bakers P & S liquid & Ointment; Fenol; Fenolo; NCI-C50124; Paoscle; Phenole; ...
Available in: Hardcover. A collection of current knowledge of phytochemicals and health Interest in phenolic phytochemicals has increased as
A HPLC method for simultaneous determination of 25 phenolic compounds in grape juice was optimized, validated and applied in the characterization of juices produced in São Francisco Valley (SFV), Brazil. The performance char- acteristics of the method were established by assays with standard solutions of phenolic compounds, spiked and unspiked samples. Linearity, matrix effects, trueness, precision, detection and quantification limits were evaluated. Linearity was demonstrated in the concentration ranges tested for all phenolic compounds. Significant matrix ef- fects were not identified for the studied compounds. Mean recoveries ranged from 86.18 to 106.50%, demonstrat- ing no lack of trueness. Precision of the method was confirmed for the 25 phenolic compounds, with acceptable repeatability relative standard deviations (from 0.71 to 9.24%) and within-reproducibility relative standard devia- tions (from 1.34 to 9.26%) for unspiked and spiked samples. The theoretical limits of detection and ...
Phenolic compounds are important components of grapes and wines. They have been found to have important roles in grape and wine systems and properties that are beneficial for human health. Vanillin (3-methoxy-4-hydroxy ...
Bisphenol A BPA Definition - Bisphenol A (BPA), is a chemical found in clear plastics. Medical research has determined that exposure to BPA has a direct...
This topic contains 40 study abstracts on Bisphenol A indicating it may contribute to Prenatal Chemical Exposures, Bisphenol-A Toxicity, and Obesity
This topic contains 40 study abstracts on Bisphenol A indicating it may contribute to Prenatal Chemical Exposures, Bisphenol-A Toxicity, and Obesity
New research presents another cause for concern in regard to the chemical bisphenol A (BPA). The study is the first to examine what impact BPA has on the DNA of mammary glands as they age.
If one researches what ingredients are in various standard cosmetics and skincare products on the market, it is a minefield of science! Here are some of the ingredients you may find in your skin and beauty products and the dangers they can cause: Alkylphenol EthoxylatesFound to reduce sperm countBenzene/Benzoic Acid/Be
Bisphenol A is an endocrine disrupting chemicals that can give someone with mild PMS a really bad case of PMS. When toxicity of Bisphenol A builds in the body, hormones throughout the body are effected.
The ACQUITY UPLC Bisphenol A Method Kit is fully compliant with ASTM Method D7574-09. As described in this method, the ACQUITY solution provides optimum resolution and sensitivity for the analysis of Bisphenol A in water.
If youre someone who tries to recycle everything, you might toss cash-register receipts in the recycling bin along with other paper. But most receipts are printed on thermal paper that requires coatings of the chemical BPA (Bisphenol A) or BPS (Bisphenol S) for the numbers to appear. BPA is a hormone disruptor that poses greatest risk to pregnant women, infants, and children; in addition, it has been linked to the risk of heart disease, diabetes, and liver toxicity. Bisphenol S has been shown to have similar effects. So if thermal paper gets recycled with other kinds of paper, it can end up in products like shopping bags, paper towels, or even toilet paper - a scary thought, indeed, since BPA can be absorbed through the skin.. So what to do, besides tossing these thermal paper receipts into the trash? For one, you could opt out of getting a sales receipt by letting the clerk know you dont want one. Or if you really need the receipt, you could request to have it emailed to you, as many ...
86 per cent of teenagers have traces of Bisphenol A (BPA), a chemical compound used to make plastics, in their body, an Engaged Research public engagement project in collaboration with the University of Exeter has found.
Get Bisphenol A type Compounds at Spectrum Chemical. SpectrumChemical.com carries a full line of fine chemicals, lab appliances and lab supplies. Spectrum Chemical offers fine chemicals in lab and production sizes.
The TriRNA Pure Kit is a spin column system for purification of high-quality total RNA from a variety of samples. Initially, samples are homogenized in TRIzol® Reagent, GENEzol™ Reagent or other phenol, guanidine isothiocyanate reagents. Chloroform phase separation or isopropanol RNA precipitation is not required.
The TriRNA Pure Kit is a spin column system for purification of high-quality total RNA from a variety of samples. Initially, samples are homogenized in TRIzol® Reagent, GENEzol™ Reagent or other phenol, guanidine isothiocyanate reagents. Chloroform phase separation or isopropanol RNA precipitation is not required.
Exposure to bisphenol A may reduce the effectiveness of chemotherapy treatments by inducing a group of proteins that protect cancer cells from the toxic effects of chemotherapy.
Bisphenol a diacetate. CAS Number: 10192-62-8. Catalog Number: AA0005VW. MDL Number: MFCD00026194. Molecular Formula: C19H20O4. Molecular Weight: 312.3597. AA Blocks.
You are viewing an interactive 3D depiction of the molecule 4,4-(2,3-diisocyano-1,3-butadiene-1,4-diyl)bisphenol (C18H14N2O2) from the PQR.
[169 Pages Report] Check for Discount on 2017-2022 Global Top Countries Hydrogenated Bisphenol A Market Report report by LP Information INC. ...
Dietary phenolic compound with the presence of C2=C3 double bond take the pre-emptive opportunities to enhance its biological effects., Lei Chen
Mounting evidence against a chemical we are exposed to daily is being ignored. What more do regulators need, ask David Melzer and Tamara Galloway
phenomenon can be attributed to several factors: First, due to the changes in the content of various phenolic compounds and second, to an increase in cell sap pH level. Sood and Nagar (2003) and Sood et al. (2006) investigated the levels of acidic and. ...
New research also shows that sanitiser can cause your skin to absorb more bisphenol A (BPA). BPA is a chemical used in the production of almost all plastics. ...
In the current study, all infants had detectable urinary concentrations of total BPA, ranging from 2.0 to 196 µg/L. The median urinary BPA concentration in this group of premature infants was considerably higher (17.2 μg/L) than in healthy term infants aged 1 to 5 months (,0.45 μg/L) without known BPA exposure.21 Although immaturity of phase II metabolism may account for some of the association of urinary BPA concentrations with prematurity, premature infants have the ability to conjugate BPA.16 Interestingly, medical devices, but not nutritional intake, were positively associated with urinary BPA concentrations. On average, premature infants requiring ≥4 medical devices had urinary total BPA concentrations 1.6 times higher than those requiring fewer devices independent of their gestational age, gender, or nutritional intake. Respiratory devices were associated with higher urinary BPA concentrations than other devices. These findings suggest that medical devices were an important source of ...
Gestational urinary BPA concentrations were associated with some neurobehavioral measures at 3 years of age in this cohort. In particular, gestational BPA exposure was associated with higher scores for measures of anxiety, hyperactivity, emotional control, and behavioral inhibition. Similar to our previous findings, the effects of gestational BPA exposure on these behavioral domains were larger among girls than boys.2 The different responses to gestational BPA exposure were especially pronounced for hyperactivity; girls exhibited increases in hyperactivity, and boys exhibited decreases in hyperactivity. In contrast, childhood urinary BPA concentrations were less important predictors of behavior or executive functions in this study.. The findings presented are consistent with numerous studies demonstrating altered neurobehavior among BPA-exposed animals.14,38 Gestational BPA exposures might affect endocrine or other neurotransmitter pathways and disrupt sexual differentiation of the brain, to ...
NIEHS Grant P30ES000002. A study, supported in part by the NIEHS, identified medical devices as a potential source of exposure to bisphenol A (BPA) among premature infants in neonatal intensive care units. BPA is used to manufacture polycarbonate plastics, which are used in medical devices such as intravenous administration sets, syringes, and catheters. The researchers looked at the urinary BPA concentration for 55 infants and categorized each infants medical device use as low or high based on the number and invasiveness of devices. They found that the median urinary total BPA concentration of infants who had required four or more medical devices for three previous days was significantly higher, 36.6 micrograms per liter (µg/l), than for the infants requiring three or less devices, who had a BPA concentration of 13.9 µg/l. The researchers also collected and analyzed breast milk or formula samples, and found that the increased BPA concentration was not associated with the infants nutritional ...
ALBERTO, María R.; MANCA DE NADRA, María C. and ARENA, Mario E.. Influence of phenolic compounds on the growth and arginine deiminase system in a wine lactic acid bacterium. Braz. J. Microbiol. [online]. 2012, vol.43, n.1, pp.167-176. ISSN 1517-8382. http://dx.doi.org/10.1590/S1517-83822012000100018.. The influence of seven phenolic compounds, normally present in wine, on the growth and arginine deiminase system (ADI) of Lactobacillus hilgardii X1B, a wine lactic acid bacterium, was established. This system provides energy for bacterial growth and produces citrulline that reacts with ethanol forming the carcinogen ethyl carbamate (EC), found in some wines. The influence of phenolic compounds on bacterial growth was compound dependent. Growth and final pH values increased in presence of arginine. Arginine consumption decreased in presence of protocatechuic and gallic acids (31 and 17%, respectively) and increased in presence of quercetin, rutin, catechin and the caffeic and vanillic phenolic ...
It is in your food containers, water bottles, and 90 percent of us have it in our bloodstream. It may also be a prime candidate for causing wheezing in children if pregnant mothers come into contact with it. Experimental research in bisphenol A, (BPA) suggests that prenatal BPA exposure causes asthma in mice. No firm data yet exists for humans but results are not looking good.. Adam Spanier, M.D., Ph.D., assistant professor of pediatrics at Penn State College of Medicine, studied 367 children, 99 percent of whom were born to mothers who had detectable BPA levels during pregnancy. Twice a year for three years, the parents reported back with any signs of wheezing in the children. At six months of age, twice as many children were reported with wheezing from mothers who had higher BPA than those who had mothers with lower BPA levels. These effects may have diminished as the children aged however.. Researchers then looked at the levels of BPA in the women during certain times of their pregnancies and ...
Early buyers will receive 10% customization on reports.. This growth is driven by rising demand from Asia-Pacific region due to highly industrialized countries, such as China. Phenol derivatives are preferred for the production of polycarbonates, epoxy resins, bakelite, and nylon.. Bisphenol -A: The most-widely used derivative of phenol derivatives. Bisphenol-A is a phenol derivative commonly used for producing polycarbonates and epoxy resins. The bisphenol-A is the most-widely used derivative of phenol. Polycarbonate finds application in food and drink packaging such as water & baby bottles, compact discs, impact-resistant safety equipment, and medical devices. Further, epoxy resins used to coat metal products such as food cans, bottle tops, and water supply pipes. BPA is also be found in certain thermal paper products, including cash register and ATM receipts.. Asia-Pacific: The largest market for phenol derivatives. The Asia-Pacific region is the largest market in the global phenol ...
TY - JOUR. T1 - Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method. AU - Sueishi, Yoshimi. AU - Ishikawa, Misa. AU - Yoshioka, Daisuke. AU - Endoh, Nobuyuki. AU - Oowada, Shigeru. AU - Shimmei, Masashi. AU - Fujii, Hirotada. AU - Kotake, Yashige. PY - 2012/3. Y1 - 2012/3. N2 - Recently, we proposed an oxygen radical absorbance capacity method that directly quantifies the antioxidants scavenging capacity against free radicals and evaluated the radical scavenging abilities for water soluble antioxidant compounds. In this study, we determined the radical scavenging abilities of lipophilic antioxidants which were solubilized by cyclodextrin in water. Commonly employed fluorescence-based method measures the antioxidants protection capability for the fluorescent probe, while we directly quantify free-radical level using electron para- magnetic resonance spin trapping technique. In addition, the spin ...
Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression by pathogens. In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant. Epidemiological studies and associated meta-analyses strongly suggest that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases. Here we present knowledge about the biological effects of plant polyphenols in the context of relevance to human health.
NIEHS Grants: R01ES016541, P01ES022844, P30ES017885, R01ES017005, R01ES017005, R01ES016001, R01ES017524. NIEHS grantees report that exposure to the endocrine-disrupting chemical bisphenol A (BPA) during pregnancy can cause oxidative damage that may increase a childs risk of developing diabetes or heart disease later in life. The researchers tested multiple species of animals to replicate and strengthen human studies that showed BPA exposure during pregnancy can bring about a specific type of oxidative stress.. Oxidative stress is associated with insulin resistance and inflammation, which are risk factors for diabetes and other metabolic disorders as well as cardiovascular disease. For the human study, the researchers analyzed blood samples from 24 mother and infant pairs. The women were divided into two groups based on their levels of BPA determined from blood draws taken during their first trimester of pregnancy. Mothers and their infants with higher levels of BPA showed increased levels of ...
New Study from CCCEH Finds Exposure to Bisphenol-A in the Womb is Linked to Behavioral Problems in Young Children. NEW YORK (April 28, 2012) Over the past few years two new phrases have been introduced to our everyday language-bisphenol-A (BPA) and endocrine disrupting chemicals. According to a new study by researchers at Columbia Center for Childrens Environmental Health at the Columbia University Mailman School of Public Health, exposure to BPA in the womb may be linked to behavioral problems in young children.. The study was published in an advance online edition of Environmental Health Perspectives entitled Prenatal Bisphenol A Exposure and Child Behavior.. BPA is found in many products we use every day, ranging from polycarbonate plastics like those used in food and beverage storage containers, the lining of canned food and beverages, thermal paper cashier receipts, to dental sealants. As a result of the high volume production and use, the majority of Americans are exposed to BPA. ...
In this study, the concentration of alkylphenol ethoxylates (APEs) and brominated flame retardants (BFRs) were determined in fish samples, Labeo umbratus and Carp, collected from the Vaal River in South Africa. Ultrasonic-assisted extraction technique was used to extract the organic contaminants from fish samples, and the resulting extract was purified by sulphuric acid lipid removal followed by Strata X-cartridge SPE clean-up. The APEs and BFRs were derivatized using heptafluorobutyric anhydride before analysis with GC-MS. In both types of fish samples, lower oligomers of APEs were more abundant than the higher oligomers, while HBCD, BDE99 and PBB101 were the dominant BFRs. The concentrations of these pollutants ranged from 1.061 ng/g lipids (t-BP) in Labeo umbratus to 11.860 ng/g lipids (HBCD) in Carp.
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Possible link between high prenatal BPA levels and neonatal neurobehavioral abnormalities; study advises pregnant women to reduce exposure levels. A new case study examining an infants neurobehavioral abnormalities and extremely high bisphenol A (BPA) concentration of the babys mother suggests a link between the two. The study, Environmental Health Perspectives: A Case Study of High Prenatal Bisphenol A Exposure and Infant Neonatal Neurobehavior, was led by researcher Sheela Sathyanarayana, MD of Seattle Childrens Research Institute, and recently published online in Environmental Health Perspectives.. BPA, a synthetic, man-made chemical, is used in a wide variety of products including: can linings; hard polycarbonate plastics such as baby bottles and reusable cups; and dental sealants. Food may be the single largest source of BPA exposure due to contamination of foods during preparation and processing. BPA has estrogenic (hormone-like) properties. In animal studies, exposure to BPA early in ...
Arnold J. Schecter and colleagues note that BPA is used in lining metal cans and in polycarbonate plastics such as baby bottles, although some manufacturers are switching to BPA-free products. In humans, BPA is associated with cardiovascular disease, diabetes, and male sexual dysfunction in exposed workers, they state. Food is a major exposure source. We know of no studies reporting BPA in U.S. fresh food, canned food, and food in plastic packaging in peer reviewed journals. To fill that gap in scientific knowledge, the scientists measured BPA levels in 105 human, cat, and dog foods. They detected BPA in 63 of 105 human food samples from grocery stores in Dallas, and present a detailed list of foods, brands, and BPA levels in the text of the study. The levels were lower than the 50 micrograms per kilogram of body weight standard used by EPA and EFSA and comparable to levels detected in the past. Schecter noted that some studies have shown adverse effects associated with exposure to BPA at ...
If youre going through fertility treatments you may want to limit your BPA exposure. A Harvard study links BPA exposure to lower IVF success rates.
2,4-Di-tert-butyl-6-({4-[(3,5-di-tert-butyl-2-hydroxyphenyl)methyl]piperazin-1-yl}methyl)phenol | C34H54N2O2 | CID 24854213 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
The amounts of total polyphenol and flavonoids in the Korean EEP samples ranged from 49 to 239 mg gallic acid equivalent (GAE)/g EEP (Brazilian, Chinese, and Australian samples, 127-142 mg GAE/g EEP) and from 21 to 50 mg quercetin equivalent (QE)/g EEP (Brazilian, Chinese, and Australian samples, 33-53 mg QE/g EEP), respectively. Correlation coefficient analysis showed that total polyphenol contents may be negatively correlated with 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity (r = -0.872) and total flavonoid content has no correlation with the activity (r = 0.071). No direct correlation between BACE-1 inhibition, AChE inhibition, or antiproliferative activity and total polyphenol or total flavonoid content in Korean EEP samples was found. Gram-positive and Gram-negative bacteria were observed to have different degrees of antimicrobial susceptibility to the EEP samples examined, although ciprofloxacin susceptibility among the bacterial groups did not differ greatly ...
MSNBC is reporting on a new study that found eating canned food every day may raise the levels of the compound bisphenol A (BPA) in a persons urine more than previously suspected, a new study suggests.. The study found people who ate a serving of canned soup every day for five days showed higher levels of BPA in their systems than those who ate no soup. The participants who ate soup during the five day test had BPA levels of 20.8 micrograms per liter of urine, whereas people who instead ate fresh soup had levels of 1.1 micrograms per liter, according to the study.. Food Court previously reported on BPA findings in popular childrens soups. In that case, and here, BPA is found in many canned foods - it is a byproduct of the chemicals used to prevent corrosion.. When the researchers looked at the rise in BPA levels seen in the average participant who ate canned soup compared with those who ate fresh soup, they found a 1,221 percent jump.. The FDA does not currently regulate BPA levels and is ...
The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) carried out an analysis of the potential for bisphenol A to trigger opposed results on copy and growth in people. The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007. CERHR chosen bisphenol A for analysis as a result of of the: widespread human publicity; public concern for doable well being results from human exposures; high manufacturing quantity; proof of reproductive and developmental toxicity in laboratory animal research Bisphenol A (CAS RN: 80-05-7) is a high manufacturing quantity chemical used primarily in the manufacturing of polycarbonate plastics and epoxy resins.. Polycarbonate plastics are used in some meals and drink containers; the resins are used as lacquers to coat steel merchandise similar to meals cans, bottle tops, and water provide pipes. To a lesser extent bisphenol A is used in the manufacturing of polyester resins, polysulfone resins, ...
The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) carried out an analysis of the potential for bisphenol A to trigger opposed results on copy and growth in people. The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007. CERHR chosen bisphenol A for analysis as a result of of the: widespread human publicity; public concern for doable well being results from human exposures; high manufacturing quantity; proof of reproductive and developmental toxicity in laboratory animal research Bisphenol A (CAS RN: 80-05-7) is a high manufacturing quantity chemical used primarily in the manufacturing of polycarbonate plastics and epoxy resins.. Polycarbonate plastics are used in some meals and drink containers; the resins are used as lacquers to coat steel merchandise similar to meals cans, bottle tops, and water provide pipes. To a lesser extent bisphenol A is used in the manufacturing of polyester resins, polysulfone resins, ...
An ongoing debate about the health impacts of bisphenol A (BPA), the ubiquitous chemical used in production of polycarbonate - that hard clear plastic we use for eating, drinking, and storing food - continues, according to a recent article by Janet Raloff published in the September 29 issue of Science News. Her analysis provides good insight into why we often hear conflicting reports when it comes to environmental and health impacts of chemicals.. Raloff reports on the conflicting results of two different panels recruited by the National Toxicology Program (NTP) and charged with reviewing and evaluating the potential developmental and reproductive impacts of BPA. While one panel labeled as confident its assessment that BPA at low doses has had negative effects on experimental animals, and that such findings were suggestive of impacts in humans, the other panel concluded that current BPA exposures appear to pose little risk to humans.. According to Raloff, one of the differences cited in ...
The adsorption of phenol on flat and stepped Pt and Rh surfaces and the dissociation of hydrogen from the hydroxyl group of phenol on Pt(111) and Rh(111) were studied by density functional calculations. On both Pt(111) and Rh(111), phenol adsorbs with the aromatic ring parallel to the surface and the hydroxyl group tilted away from the surface. Furthermore, adsorption on stepped surfaces was concluded to be unfavourable compared to the (111) surfaces due to the repulsion of the hydroxyl group from the step edges. Transition state calculations revealed that the reaction barriers, associated with the dissociation of phenol into phenoxy, are almost identical on Pt and Rh. Furthermore, the oxygen in the dissociated phenol is strongly attracted by Rh(111), while it is repelled by Pt(111).
Several activated carbons (ACs) were used as metal-free catalysts for degradation of a toxic organiccompound, phenol, in the presence of different oxidants, H2O2, peroxydisulfate (PS) and peroxymonosulfate (PMS). It was found that ACs were effective in heterogeneous activation of PMS toproduce sulfate radicals for degradation of phenol, much better than H2O2 and PS. Particle size of AC significantly influenced AC activity, and powder AC was much more effective than granular AC. The complete phenol removal could be achieved in 15 min on powder activated carbon (PAC) under the conditions of [phenol] = 25 mg L-1, [PAC] = 0.2 g L-1, [PMS] = 6.5 mmol L-1, and T = 25 degrees Celcius. It was also found that phenol degradation was significantly influenced by PMS loading, catalyst loading, phenol concentration and temperature. Surface activation of PMS and phenol adsorption played important roles in phenol degradation. Surface coverage by intermediate adsorption and structural change induced deactivation ...
Stearyl .beta.-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Stearyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate Stearyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate Sumilizer BP 76 THANOX 1076 U 276 Total tonnage band Total range: 10 000+ tonnes per annum REACH Registered as: FULL Submitted: Joint Submission Publication dates First published ...
Introduction. 1. Give an account of the properties and uses of phenol. (1) Phenol is acidic and its conjugate base, phenoxide ion is stabilized by resonance. However, phenol is not acidic enough to liberate CO2 from phenol because an aqueous solution of carbon dioxide is a stronger acid than phenol. An aqueous solution of phenol has a pH value of 9. This means phenol reacts with NaOH but not NaHCO3. Phenol dissolves in NaOH(aq) to form sodium phenoxide, an ionic salt. (2) Phenol is corrosive and is a useful antiseptic. (3) Phenol is a colorless solid of low melting point. Its pink appearance is due to the presence of impurities. (4) When attached to a benzene ring, a hydroxyl group does not show the properties of an alcohol. The delocalization of electrons into the ring makes the -OH group inert towards replacement. On the other hand, the -OH group activates the ring toward electrophilic substitution at the ortho- and para-positions. Therefore, phenol reacts with (a) NO2+, (b) CH3+, (c) CH3CO+, ...
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Subjects and methods subjects and samples collected 42 male workers, their job was to spray badges in a machine factory and two related factories in Aichi Prefecture using mixed organic solvents as epoxy resin hardening agents as exposure workers in this study ...
Background: Flavonoids have been implicated in the prevention of cardiovascular disease; however, their mechanisms of action have yet to be elucidated, possibly because most previous in vitro studies have used supraphysiological concentrations of unmetabolized flavonoids, overlooking their more bioavailable phenolic metabolites. Objective: We aimed to explore the effects of phenolic metabolites and their precursor flavonoids at physiologically achievable concentrations, in isolation and combination, on soluble vascular cellular adhesion molecule-1 (sVCAM-1). Method: Fourteen phenolic acid metabolites and 6 flavonoids were screened at 1 μM for their relative effects on sVCAM-1 secretion by human umbilical vein endothelial cells stimulated with tumor necrosis factor alpha (TNF-α). The active metabolites were further studied for their response at different concentrations (0.01 μM-100 μM), structure-activity relationships, and effect on vascular cellular adhesion molecule (VCAM)-1 mRNA ...
The study conducted by researchers at the Harvard School of Public Health (HSPH) found that a group of volunteers who consumed a serving of canned soup each day for five days had a more than 1,000 percent increase in urinary bisphenol A (BPA) concentrations compared with when the same individuals consumed fresh soup daily for five days ...
The list of adverse health effects from BPA exposure continues to grow. Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat.
The list of adverse health effects from BPA exposure continues to grow. Bisphenol A, or BPA, is commonly used to line food and beverage cans, and helps to keep plastics flexible, but studies suggest the compound can leach into the foods we eat.
Figure 6: Antioxidant, Cytotoxic, and Antiproliferative Activities and Total Polyphenol Contents of the Extracts of |i|Geissospermum reticulatum|/i| Bark
Phenol is one of toxic pollutants in many kinds of hypersaline industrial effluents which should be treated properly before discharged into water bodies. In this work, a halophilic strain which could utilize phenol as the sole source of carbon and energy was isolated. Based on 16S rRNA results, it was identified as a member of Citrobacter. The phenol biodegradation ability and cell growth of the strain was evaluated with the variation of initial phenol concentration and salinity. The effect of temperature and pH on phenol removal was also investigated. The results showed that the strain was capable of withstanding high phenol (up to 1,100 mg L−1) environment with varying salinity conditions (0-10% of NaCl). The optimal initial phenol concentration was 400 mg L−1, with which the average removal rates of phenol peaked at 10.8 mg L−1 h−1. The higher initial concentration of phenol could inhibit the microbial metabolism. The optimal temperature, pH and salinity were 35 °C, 6.0, and 0%, ...
Current human exposure to bisphenol A (BPA), a chemical used in many polycarbonate plastics and epoxy resins, is of some concern for effects on development of the prostate gland and brain and for behavioral effects in fetuses, infants and children, according to a final report released today by the National Toxicology Program (NTP).
Data & statistics on Bisphenol India: Dilution table for bisphenol A and bisphenol F., Properties of two types of polycarbonates, that is, Bisphenol A polycarbonate (BPAPC) and Poly(diethylene glycol di(allyl carbonate)) (PDEGDAC) [2]., Gharravi AM, et al: Altered pituitary hormone in male rats exposed to Bisphenol A...
Oleocanthal is a natural phenolic compound found in Extra Virgin Olive Oil (EVOO). The importance and uniqueness of Oleocanthal is that it has antioxidant and anti-inflammatory properties.
New research led by researchers at North Carolina State University shows that exposure to the chemical bisphenol A (BPA) early in life results in high levels of anxiety by causing significant gene expression changes in a specific region of the brain called the amygdala. The researchers also found that a soy-rich diet can mitigate these effects.. We knew that BPA could cause anxiety in a variety of species, and wanted to begin to understand why and how that happens, says Dr. Heather Patisaul, an associate professor of biology at NC State and lead author of a paper describing the work. BPA is a chemical used in a wide variety of polycarbonate plastics and epoxy resins, and is used in consumer products such as some food containers.. In the study, rats were exposed to low doses of BPA during gestation, lactation (nursing) and through puberty. One group of animals was fed only soy; one group was fed a soy-free diet; one group was fed only soy and exposed to BPA; and one group was fed no soy and ...
Silica-gel column chromatography (clean-up). The chromatographic column (20 cm × 8 mm I.D.) was packed with 5.0 g of activated silica gel, which was made into a slurry with 1.5% (v/m) petroleum ether and then stirred well before use. About 1 mℓ of anhydrous sodium sulphate was placed at the top of the column to absorb any water in the sample or the solvent. The column was pre-eluted with 15 mℓ of petroleum ether and before exposure to sodium sulphate. The reduced 5 mℓ extract resulting from the extraction processes was placed in the column and allowed to sink below the sodium sulphate layer. APEs extracts were eluted with 2 × 10 mℓ portions of the extracting solvents. The eluant was collected, bubbled with nitrogen gas to dryness and reconstituted with 2 mℓ of extracting solvent. Then 1.0 µℓ was injected into the GC.. Sampling protocol. Description of the study area. The study area for this research work was the Jukskei River catchment area, which is located in the Gauteng and ...
Research has called into question the role of plant polyphenols in cardiovascular health, by finding that their supposed anti-platelet activities are only relevant at high, and physiologically unattainable, concentrations.
Bisphenol A (BPA) is used in the manufacture of many products and is ubiquitous in the environment. Adverse effects of BPA on animal reproductive health have been reported, however most of the studies relied on the approaches in the assessment of conventional histology and anatomical features. The mechanistic actions of BPA are not clear. In the present study, a murine model was used to study potential effects of BPA exposure during perinatal and postnatal periods on endocrine functions of hypothalamic-pituitary-gonadal (HPG)-axis. At the hypothalamic-pituitary level, BPA exposure resulted in the up-regulation of the expression levels of KiSS-1, GnRH and FSH mRNA in both male and female pups. At the gonadal levels, BPA caused inhibition in the expressions of testicular steroidogenic enzymes and the synthesis of testosterone in the male pups. Conversely exposure to BPA resulted in a greater aromatase expression level and the synthesis of estrogen in the female pups. BPA is a weak estrogen agonist ...
Title: Polyphenols: Biological Activities, Molecular Targets, and the Effect of Methylation. VOLUME: 1 ISSUE: 3. Author(s):K. R. Landis-Piwowar and Q. P. Dou. Affiliation:Karmanos Cancer Institute, 540.01 HWCRC 4100 John R Road, Detroit, Michigan 48201-2013, USA.. Keywords:Proteasome inhibitor, molecular target, natural product, drug discovery, anticancer. Abstract: Polyphenolic compounds are widely distributed in the plant kingdom and the anticancer benefits obtained from their consumption have been studied extensively. However, polyphenols are subject to various biotransformation reactions within the human body including methylation. Likewise, naturally occurring polyphenols may contain O-methylations in place of the hydroxyls of the parent compounds. While some studies suggest that methylations can increase the bioavailability of polyphenols, other studies indicate a decrease in the anticancer benefits of methylated polyphenols. This review will focus on the cellular activities of ...
Exposure to the endocrine-disrupting chemical bisphenol A during pregnancy can cause oxidative damage that may put the baby at risk of developing diabetes or heart disease later in life, according to a new study published in the Endocrine Societys journal Endocrinology.
The aim of the study was to determine total phenolics, flavonoid contents and antioxidant activity in some Eulophia species (Orchidaceae). Rhizomes of Eulophia species viz. E. nuda, E. ochreata, E. herbacea, E. ramentacea, E. andamanensis and E. epidendrea were extracted with petroleum ether, methanol, acetone and Distilled water.
Recent research suggests that blueberries are rich in total polyphenols and total anthocyanins. Phenolic compounds are highly unstable and may be lost during processing, particularly when heat treatment is involved. There is no systematic study available providing information on the fate of phenolic …