A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and ...
Title:A UPLC-MS/MS Method for Simultaneous Determination of Six Bioactive Compounds in Rat Plasma, and its Application to Pharmacokinetic Studies of Naoshuantong Granule in Rats. VOLUME: 15 ISSUE: 3. Author(s):Ping Wang, Shenmeng Jiang, Yu Zhao, Shuo Sun, Xiaoli Wen, Xingjie Guo* and Zhen Jiang*. Affiliation:Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang ...
This study presents the evaluation of seven pharmaceutical compounds belonging to different commonly used therapeutic classes in seawater samples from coastal areas of Gran Canaria Island. The target compounds include atenolol (antihypertensive), acetaminophen (analgesic), norfloxacin and ciprofloxacin (antibiotics), carbamazepine (antiepileptic) and ketoprofen and diclofenac (anti-inflammatory). Solid phase extraction (SPE) was used for the extraction and preconcentration of the samples, and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for the determination of the compounds. Under optimal conditions, the recoveries obtained were in the range of 78.3% to 98.2%, and the relative standard deviations were less than 11.8%. The detection and quantification limits of the method were in the ranges of 0.1-2.8 and 0.3-9.3 ng·L−1, respectively. The developed method was applied to evaluate the presence of these pharmaceutical compounds in seawater from four outfalls in Gran Canaria Island
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ABSTRACT. The aim of this study is to present a Quick and Easy formula for the calculations of percent spike recovery of drug samples. Currently there are several cumbersome methods used in the determination of percent spike recovery in pharmaceutical analyses performed in various laboratories including the FDA laboratories around the world and especially in USA. In this paper we have compared the Quick & Easy Method using Pals formula against the method suggested by ORA Manual. The efficacy of this new formula has been demonstrated by seven examples including the main example of Pilocarpine hydrochloride discussed in detail. This Quick & Easy method is very simple, efficient and convenient way of determining percent spike recoveries and RPD values of duplicate spike solutions in drug analyses by HPLC, GC or UV methods. The simplicity of the method saves time and effort when compared to the existing method. Keywords: Pals formula, ORA Manual. ...
Current Pharmaceutical Analysis publishes authoritative reviews, written by experts in the field on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.. ...
Pharmaceutical Drugs are defined as chemical substances used for treating, curing and preventing different types of diseases. Commonly referred as medicines or medication, pharmaceutical drugs are used in the medical diagnosis, treatment, prevention or curing disease. For varied diseases, physical ailments, there are a wide range of pharmaceutical drugs which are available over the counter (OTC) or with doctors advise.
Our GMP pharmaceutical laboratories provide chemistry, manufacturing and controls (CMC) analytical laboratory services in accordance with current Good Manufacturing Practice (cGMP). Intertek provides cGMP compliant pharmaceutical analysis services that meet the requirements of regulatory authorities worldwide. Laboratory services supporting GMP and CMC requirements range from early development characterization, formulation support analysis, stability testing and method development and method validation through to GMP batch release testing. Our experienced scientists can support your development or manufacturing activities for both small molecule pharmaceuticals and biopharmaceuticals such as proteins, monoclonal antibodies and vaccines. Our GMP laboratory teams have extensive experience with drug delivery systems, drug device combinations and a wide range of medical devices.. cGMP Compliant Analytical Laboratories:. ...
This title simplifies the understanding of the basic principles of Pharmaceutical Analysis by bridging the gap between the basics and complex topics such as spectrometry, chromatography, and various thermal analysis techniques. The title is a must-read for pharmacy graduates.
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polysaccharide (9.522) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [triterpene (5.647) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [ganoderic acid (5.384) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [lucidenic acid (2.999) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [Gl-PS (2.998) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [lanostanoid (2.645) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [ergosterol (2.234) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [laccase (2.230) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [proteoglycan (1.997) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [F3 (1.993) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [terpenoid (1.987) (E)Literature evidences(S)STITCH: Chemical-Protein Interactions] [more] [Help ...
Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. The thesis comprises an overview of the field together with separate studies on the different topics.. The utility of CE for the determination of pKa of labile drug compounds was investigated. A general methodology was developed comprising key steps such as the use of a stabilising sample diluent, electromigration injection, and analyte characterisation by UV-Vis spectroscopy. The methodology was successfully applied for two sets of drug compounds, labile at low and high pH, respectively.. CE was also evaluated for experimental modelling of passive intestinal membrane permeability by studying analyte migration in liposomal, microemulsion and micellar electrolytes. Good correlation is ...
An analytical method for the simultaneous determination of eight pharmaceutical compounds in biosolids from urban wastewater treatment plants (WWTPs) was developed and validated. The compounds evaluated were non-steroidal anti-inflammatory drugs (naproxen, diclofenac, and ibuprofen), lipid regulators (clofibric acid), and antibiotics (sulfathiazole, sulfapyridine, sulfamethazine, and sulfamethoxazole). Ultrasound assisted extraction with a water-methanol solvent mixture (1:1, v:v) was performed and the compounds were then determined by liquid chromatography coupled with tandem mass spectrometry. The design of the method was based on the application of the standard addition calibration methodology to reduce matrix interferences. Validation procedures were conducted with rabbit excrements as blank samples. Recoveries of the target analytes ranged from 76 to 131% in spiked samples at 50, 200 or 1000 ng g−1 dry weight (dw). The relative standard deviations were in the range of 5-15% and the method ...
HPLC Application #15626: Pharmaceutical Compounds by Luna 3µ C18(2) MercuryMS Cartridge 20 x 4.0mm. Column used: Luna® 3 µm C18(2) 100 Å, LC Column 20 x 4 mm, Mercury, Ea Part#: 00M-4251-D0-CE
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China Pharmaceutical Drug Glimepiride 93479-97-1 for Treating Diabetes, Find details about China Glimepiride, 93479-97-1 from Pharmaceutical Drug Glimepiride 93479-97-1 for Treating Diabetes - Wuhan Lianshangwang Technology Co., Ltd.
A method is disclosed for delivering molecules such as pharmaceutical drugs and nucleic acids into skeletal muscle in vivo. The pharmaceutical drug or nucleic acid is first injected into the muscle at
TY - JOUR. T1 - Drug compound characterization by mass spectrometry imaging in cancer tissue. AU - Kwon, Ho Jeong. AU - Kim, Yonghyo. AU - Sugihara, Yutaka. AU - Baldetorp, Bo. AU - Welinder, Charlotte. AU - Watanabe, Ken Ichi. AU - Nishimura, Toshihide. AU - Malm, Johan. AU - Török, Szilvia. AU - Döme, Balázs. AU - Végvári, Ákos. AU - Gustavsson, Lena. AU - Fehniger, Thomas E.. AU - Marko-Varga, György. PY - 2015/9/22. Y1 - 2015/9/22. N2 - MALDI mass spectrometry imaging (MSI) provides a technology platform that allows the accurate visualization of unlabeled small molecules within the two-dimensional spaces of tissue samples. MSI has proven to be a powerful tool-box concept in the development of new drugs. MSI allows unlabeled drug compounds and drug metabolites to be detected and identified and quantified according to their mass-to-charge ratios (m/z) at high resolution in complex tissue environments. Such drug characterization in situ, by both spatial and temporal behaviors within ...
Expertise:. » Isolation, characterization and evaluation of bioactive constituents from herbal extracts using bioactivity guided fractionation. » Computer aided Drug Design (in silico analysis), synthesis and pharmacological evaluation (in vitro analysis) » Resolution of drugs, including enzymatic resolution and its monitoring. » Chiral chromatography » Forced degradation studies, Impurity profiling and development of stability indicating assays. » Analytical method development and validation » Synthesis, purification and characterization of impurities/metabolites. » Structural Elucidation using spectroscopic techniques » Bioanalytical method development and validation; Therapeutic Drug Monitoring » Drug metabolism and pharmacokinetic analysis » Herbal Analysis » In vitro analysis for antibacterial, antifungal and antiamoebic activity Go to TOP ...
In the Laboratory of Drug Quality and Registration (DruQuaR) fundamental and applied research is carried out in the fields of pharmaceutical analytics and regulatory affairs.. Our general research goal is studying the functional quality of pharmaceuticals and related products. Emphasis is placed on the following, more specific topics:. ...
Micellar liquid chromatography (MLC) is an analytical technique belonging to the wide range of reversed-phase liquid chromatographic (RP-LC) separation techniques. MLC with the use of surfactant solutions above its critical micellar concentration (CMC) and the addition of organic modifiers is currently an important analytical tool with still growing theoretical considerations and practical applications in pharmaceutical analysis of drugs and other biologically active compounds. The use of MLC as an alternative, relatively much faster in comparison to conventional chromatographic separation techniques has several advantages, especially as being suitable for screening pharmaceutical analysis. The analytical data received from MLC analysis are considered a useful source of information to predict passive drug absorption, drug transport and other pharmacokinetics and physicochemical measures of pharmaceutical substances. In the review several MLC assays for determination of drugs and other active ...
Dr Khaled H Assi obtained his BSc in the Sciences of Chemistry in 1994 and was awarded the PhD in pharmaceutical analysis by the University of Bradford, in 1999.. He then took up a post doctoral post at university of Bradford between 1999-2001 working on the inhaled therapies. His post doctoral program was extended for one more year through an awarded grant from Glaxo SmithKline joint with Professor H Chrystyn .. In 2002, he was accepted a research fellowship at Bradford School of Pharmacy. Dr Assi was appointed as a Lecturer at the Bradford School of Pharmacy, in July 2004 and has continued developing his research in the inhaled therapies area. In this position he is teaching the pharmacy and pharmaceutical management students at different levels. The modules he delivers cover the area of pharmaceutical analysis, Quality assurance and quality control of pharmaceuticals.. He is also active in the research. His research interests cover the inhalation therapies and developing of pharmaceutical and ...
This 2-day HPLC course is aimed at those who are new to the technique of HPLC and want to use it for the analysis of pharmaceuticals. The training course is delivered at your companys site by the MTS trainer. A pre-training visit may be arranged during which the MTS trainer will discuss the content of the training course with you to ensure that the HPLC training is fully tailored to your needs.
Paper analytical devices (PADs) are test cards that can quickly determine whether a drug tablet contains the correct medicines. They are cheap and easy to use. They dont require power, chemicals, solvents, or any expensive instruments, so they can be deployed rapidly at large scale whereever a problem with pharmaceutical quality is suspected.
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Near-infrared spectroscopy as a rapid and non-destructive analytical technique offers great advantages for pharmaceutical raw material identification (RMID) to fulfill the quality and safety requirements in pharmaceutical industry. In this study, we demonstrated the use of portable miniature near-infrared (MicroNIR) spectrometers for NIR-based pharmaceutical RMID and solved two challenges in this area, model transferability and large-scale classification, with the aid of support vector machine (SVM) modeling. We used a set of 19 pharmaceutical compounds including various active pharmaceutical ingredients (APIs) and excipients and six MicroNIR spectrometers to test model transferability. For the test of large-scale classification, we used another set of 253 pharmaceutical compounds comprised of both chemically and physically different APIs and excipients. We compared SVM with conventional chemometric modeling techniques, including soft independent modeling of class analogy, partial least squares ...
A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical preparation comprising a water-soluble polymeric substance having a Youngs modulus of 10 to 250 Kg/mm2 as determined at a temperature of 25 C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20 C. and a medicinal agent for remedy of periodontal diseases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic solvent by drying to obtain a pharmaceutical preparation in the form of a film or sheet.
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InnovaSystems is an engineering company that has provided automated test solutions for pharmaceutical drug delivery systems since 1989.
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0068]This analysis is carried out on sections of pancreatic tissue (corresponding to the head of the pancreas). Once the sections have been obtained (described in example 3) they are placed on a slide and the tissue is then deparaffinated and rehydrated. It is begun in pure xylol, with two changes of 10 minutes each. The samples are then passed to a mixture of ethanol-xylol for 10 minutes and afterward to alcohols of different percentages: 100, 90, 80 and 70% for five minutes each. Finally, they are passed to a PBS solution (phosphate buffered solution) for 30 minutes in order to then carry out the immunostaining process. This is begun with the incubation of the samples in a PBS-Triton solution for 10 minutes at an ambient temperature (20-22° C.), they are flushed with PBS without triton and the samples are blocked with albumin in PBS. The samples are flushed with PBS for 1 to 5 minutes. A mixture is then made of primary antibodies anti-insulin and anti-glucagon in PBS and they are left to ...
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Advances in modern high-performance liquid chromatography (HPLC) have led to increased interest in the comparison of the ultimate performance limits of methodologies aimed at increasing the resolving power per unit time. Kinetic plot-based methods have proven invaluable in facilitating such evaluations. However, in bridging the gap between fundamental comparisons and the eventual practical applicability of kinetic performance data, the effect of analyte properties have thus far largely been neglected. Using pharmaceutical compounds as representative real-life analytes, it is demonstrated that noteworthy differences in the optimal kinetic performance of a chromatographic system are observed compared to data for common test compounds. For a given stationary phase particle size, higher optimal- and maximum plate numbers, corresponding to increased analysis times, are measured for pharmaceutical compounds. Moreover, it is found that the optimal particle size/maximum pressure combination depends on ...
Is an executive order from the president forcing the FDA to supply the nation with more pharmaceutical drugs the answer to the nations health crisis? It isnt a pharmaceutical drug deficiency that is causing such health ailments, but rather a weak immune system deficient in vital vitamins and nutrients. There have been some great advancements in the field of nutritional science, but pharmaceutical drugs have become the only solution as far as the medical establishment goes. Interestingly, There have been zero deaths as a result of vitamins and over 3 million deaths related to prescription drug use over the past 27 years. But why are natural solutions - which actually have virtually no side effects and boost overall immunity - being ignored? Turmeric alone is known to positively affect over 573 diseases and has even decreased brain tumor size in animals by 81 percent in more than 9 studies. So why hasnt turmeric been recommended as an inexpensive and powerful solution, potentially saving ...
General pharmacology:. 1. Pharmacology, sub-branches, origin of drugs, drug names. 2. Types of pharmacotherapy, rules of rational and safe phramacotherapy. The question of drug misuse. 3. Preclinical and clinical trials, stages. 4. Basic legislation related to drug use, Sources of information on drugs and medicinal products. 5. Solid and gaseous pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics. 6. Semi-solid and liquid pharmaceutical drug dosage forms - overview and their influence on pharmacokinetics and pharmacodynamics. 7. Routes of drug administration - overview, characteristics. 8. Drug absorption, presystemic elimination, drug bioavailability. 9. Drug distribution, volume of distribution, redistribution. General principles of drug movement through the body. 10. Drug elimination, processes of the first and zero order, drug accummulation. 11. Drug biotransformation - stages, examples. 12. Drug excretion (ways of excretion, possibilities ...
in Osteoarthritis and Cartilage (2004), 12(4), 263-268. Background: Recent innovations in the pharmaceutical drug discovery environment have generated new chemical entities with the potential to become disease modifying drugs for osteoarthritis (DMOADs ... [more ▼]. Background: Recent innovations in the pharmaceutical drug discovery environment have generated new chemical entities with the potential to become disease modifying drugs for osteoarthritis (DMOADs). Regulatory agencies acknowledge that such compounds may be granted a DMOAD indication, providing they demonstrate that they can slow down disease progression; progression would be calibrated by a surrogate for structural change, by measuring joint space narrowing (JSN) on plain X-rays with the caveat that this delayed JSN translate into a clinical benefit for the patient. Recently, new technology has been developed to detect a structural change of the OA joint earlier than conventional X-rays. Objective: The Group for the Respect of ...
TY - JOUR. T1 - Patients appropriateness, acceptability, usability and preferences for pharmaceutical preparations: Results from a literature review on clinical evidence. AU - Drumond, Nélio. AU - van Riet-Nales, Diana A.. AU - Karapinar-Çarkit, Fatma. AU - Stegemann, Sven. PY - 2017/2/14. Y1 - 2017/2/14. N2 - Patients play an important role in achieving the desired therapeutic outcomes, as they are frequently responsible for their own medication management. To facilitate drug administration and overcome medication issues, the patients needs and preferences should be considered in the pharmaceutical drug product design. With the aim to evaluate the current state of evidence for patient appropriateness, acceptability, usability and preference for aspects of this design, a literature search was performed. Comparative clinical studies that assessed such endpoints for different patient populations were included and summarized descriptively. The search identified 45 publications that met the ...
24 Topics on Drug Metabolism Dresser, G. , Kim, R. B. & Bailey, D. G. (2005). Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. 3, pp. 170-177. Enerson, B. E. & Drewes, L. R. (2003). Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. 8, pp. 1531-1544. , Kindmark, A. & Artursson, P. (2006). Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells. Webster, L. , Wring, S. , Shampine, L. , SerabjitSingh, C. , Adkison, K. K. & Polli, J. W. (2002). Passive permeability and Pglycoprotein-mediated efflux differentiate central nervous system (CNS) and nonCNS marketed drugs. 3, pp. 1029-1037. , Wilson, M. , Sessions, R. B. & Halestrap, A. P. (2006). 486-498. Martinez, M. N. & Amidon, G. L. (2002). A mechanistic approach to understanding the factors affecting drug ...
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Drug Analysis by Chromatography and Microscopy by E. Stahl, 9780250975211, available at Book Depository with free delivery worldwide.
to the editor: I was chagrined to recently find an unexpected piece of paper glued to the U.S. Food and Drug Administration (FDA) package insert inside a sample box of metformin (Glucophage). This advertisement and coupon for Choice dm, an over-the-counter "nutritional bar and beverage," offered 25 cents off. It further asked the patient to complete demographic information on the coupon and a questionnaire to be mailed back to Bristol-Myers Squibb.. Im sure that I have unknowingly given this advertisement to numerous indigent diabetic patients on continuous therapy. I only found the advertisement while initially starting a patient on metformin and giving her the enclosed FDA patient label that discusses lactic acidosis. The outside of the sample box gave no indication of the advertisements inclusion inside. In this particular case, I certainly dont want to encourage my diabetic patients to consume products that look like candy bars and milkshakes. In the bigger picture, I do not ever want to ...
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This review updates and follows-up a previous review by highlighting recent advancements regarding capillary electromigration methodologies and applications in pharmaceutical analysis. They were analyzed by P32 gene-based molecular methods and a species-specific PCR based on the RPO30 gene. Including evidence from ...
National Drug Source is a full line pharmaceutical distributor/wholesaler/exporter. We service distributors, hospitals and government agencies.
Natural products space includes at least 200,000 compounds and the structures of most of these compounds are available in digital format. Previous analyses showed (i) that although they were capable of taking up synthetic pharmaceutical drugs, such exogenous molecules were likely the chief natural substrates in the evolution of the transporters used to gain cellular entry by pharmaceutical drugs, and (ii) that a relatively simple but rapid clustering algorithm could produce clusters from which individual elements might serve to form a representative library covering natural products space. This exploited the fact that the larger clusters were likely to be formed early in evolution (and hence to have been accompanied by suitable transporters), so that very small clusters, including singletons, could be ignored. In the latter work, we assumed that the molecule chosen might be that in the middle of the cluster. However, this ignored two other criteria, namely the commercial availability and the financial
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CHICAGO, March 4, 2019 /PRNewswire/ -- According to the new market research report Pharmaceutical Drug Delivery Market by Route (Oral (Tablet), Pulmonary (Nebulizer), Injectable, Ocular (Liquid), Topical (Solid), Implantable (Active), Transmucosal), Application (Cancer, Diabetes), Patient Care Setting (Hospital) -...
Established in the year 2012 in India INDOKEM HEALTH CARE. Indokem Health Care is one of the most popular pharmaceutical company. At IHC, our mission is to improve the quality of life by enabling people to do more, feel better and live longer. This mission drives us to make a real difference to the lives of millions of people with our commitment to effective healthcare solutions. The IHC products portfolio includes prescription medicines, injections, syrups. Our prescription medicines range across therapeutic areas such as anti-infectives, dermatology, gynaecology, diabetes, cardiovascular disease and respiratory diseases. The company is the market leader in most of the therapeutic categories in which it operates.. ...
As the country goes through another excruciating health-care fight in Washington, I find myself watching more CNN than I should, and I cant help but notice the commercials. Half of them (I exaggerate only slightly) are for weight-loss schemes, in which the pre-packaged, highly processed meals sent to your door somehow shrink your waistline. The other half are for pharmaceutical drugs meant to treat diet-related diseases such as diabetes and heart disease. (Given that were the only country in the world except New Zealand that allows direct-to-consumer marketing of pharmaceutical drugs, these numbers are not altogether surprising.). Our health-care problem is often symbolized by the number 17: the percentage of GDP that we spend on it, a figure higher than almost any country in the world. Three different numbers should take its place: Americas rank in the global charts for diabetes, heart disease, and obesity.. Among its wealthy, industrialized peers, the United States is close to having the ...
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Did you catch this folks? One in three medications to hit the market had serious safety events (i.e. side effects) that showed up after the fact. Why after the fact? Listen to what lead author, Dr. Nicholas Downing, said in an interview given to MedPage Today. "pre-market clinical trials, which usually involve fewer than 1,000 patients who take the drugs for a few months, are, by definition, not designed to identify long-term safety issues with the drugs." Did you catch that? Hes spot on. How in the world can a person who has taken a drug for a few months have any idea whether or not it is doing something in their body that might be causing long-term ill effects / accumulative damage? Plainly stated, they cant. And even though many of these drugs have been given black box warnings and "safety communications," by our TRUSTED FRIENDS IN THE FDA, few of these medications are ever removed from the market. But here is the real kicker ...
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Find a famous anti-epileptic medication and a group of drugs like anticonvulsants, the use of adults and kids, active ingredients and any kind of allergic reaction, consultation with doctors - all other information about drug on the page of Catalog.md
Pharmaceutical compounds which are azolo-fused pyrimidine compounds having the formula ##STR1## in which .dbd.A--B-- together with the pyrimidine ring forms a) a pyrazolo[1,5-a]pyrimidine of formula (A), ##STR2## b) a [1,2,4]triazolo[1,5-a]pyrimidine of formula (B), ##STR3## c) an imidazo[1,5-a]pyrimidine of formula (C), ##STR4## or d) an imidazo[1,2-a]pyrimidine of formula (D), ##STR5##
Pharmaceutical companies can use in vitro testing for assessing worker safety. Pharmaceutical intermediates should be evaluated to determine the primary hazards associated with them so that those involved in the manufacturing process can take necessary precautions to avoid hazardous exposures.. Pharmaceutical compounds can vary widely in their physical forms, such as powders, liquids, and creams. Many in vitro assays such as those using 3-dimensional tissue constructs, and the Bovine Corneal Opacity and Permeability (BCOP) Assay, are suitable for testing different test article forms, and can provide predictions on the hazards associated with them. Testing can be structured by taking a tiered-testing approach depending on the expected irritation levels of the products, and using the protocol best suited for the test material. This could help to eliminate unnecessary testing. Protocols that align with OECD test guidelines for classification according to GHS hazards can be used, or companies may ...
In practical terms, tropical forest species serve modern medicine in three main ways.[17] First, extracts from organisms can be used directly as drugs; and they can serve in semi-synthesis of drug derivatives and active therapeutic agents. Second, the chemical structures of forest organisms offer templates, or blueprints, to enable researchers to chemically synthesize drug compounds. Third, forest organisms serve as research aids for the development and testing of drugs and pharmaceuticals, also for the needs of biomedical research generally.. 1. Direct or Semi-Direct Use of Organisms as Drugs. First off, let us briefly review those biocompound extracts from plants and animals that can be used as drugs with little more ado. A vast number of tropical forests species yield substances that are pharmacologically important in the manufacture of ethical drugs. A survey of U.S. prescriptions in 1973 showed that the plant kingdom was already supplying 76 drug compounds, a total that has grown still ...
By: Rakesh Gollen and Beata Sweryda-Krawiec Drug delivery refers to approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effect. The ultimate goal of drug delivery research is to help patients by developing clinically useful formulations. In last few decades, many new strategies have been…
In this report we provide mass spectrometry imaging data within various cancers such as malignant melanoma in patients administered with Vemurafenib, a protein kinase inhibitor that is targeting both the BRAF, and ERK mutated target proteins and that has shown significant efficacy in restraining disease progression. We also provide an overview of other examples of the new generation of targeted drugs, and demonstrate the data on personalized medicine drugs localization within tumor compartments within in vivo models. In these cancer models we provide detailed data on drug and target protein co-localization of YCG185 and Sunitinib. These drugs are targeting VEGFR2 within the angiogenesis mechanism ...
Most proteins interact with small-molecule ligands such as metabolites or drug compounds. Over the past several decades, many of these interactions have been captured in high-resolution atomic structures. From a geometric point of view, most interaction sites for grasping these small-molecule ligands, as revealed in these structures, form concave shapes, or "pockets", on protein surface. An efficient method for comparing these pockets could greatly assist the classification of ligand-binding sites, prediction of protein molecular function, and design of novel drug compounds. We introduce a computational method, APoc (Alignment of Pockets), for large-scale structural comparison of protein pockets. A scoring function, Pocket Similarity Score (PS-score), is derived to measure the level of similarity between pockets. Statistical models are employed to estimate the significance of PS-score based on millions of comparisons of random pockets. Apoc is a general, robust method that may be applied to ...
Pion ? Determination and prediction of solubility, dissolution, permeability and human absorption is Pion?s core business. We screen and analyze pharmaceutical compounds using instrumentation, software and laboratory services.
Pion - Determination and prediction of solubility, dissolution, permeability and human absorption is Pions core business. We screen and analyze pharmaceutical compounds using instrumentation, software and laboratory services.
Enzyme catalyzed reactions have several advantages over conventional synthetic reactions. The use of enzymes is rapidly increasing in industry. The specificity of enzymes has considerable potential for the production of complex pharmaceutical compounds. Incorporating enzyme catalyzed steps into the production of molecules like TAXOL® could enable their cost effective production from common starting materials. As a bulk catalyst, enzymes have several disadvantages that have limited their use as an industrial catalyst, such as product inhibition and cost. However, the problems associated with enzymes in bulk reactions can be circumvented by attaching them to a fixed matrix. In this type of continuous flow reactor (CFR), product does not accumulate to appreciable concentrations, and enzymes remain separated from the reaction mixture, while exhibiting a high activity and stability. For these reasons, immobilized enzyme-based CFRs have long been a topic of interest, without major success due to the
So does the testing of biomedical or pharmaceutical compounds on primates really advance medicine? Its a controversial question, with some arguing that the use of so-called non-human primates is vital to biomedical research. But an undercover
Manipulation of exposures in humans, many of which may be harmful, is frequently infeasible, unethical or both. Therefore, epidemiologists have to base their inferences on experiments that humans subjects themselves to intentionally, naturally, or even unconsciously. Because human life is characterized by a myriad of complex, often interrelated behaviors and exposures-ranging from genetic traits and features of the intrauterine environment to growth rate, physical activity, sexual practices, use of tobacco, alcohol and pharmaceutical compounds, dietary intake, exposure to infections, environmental pollutants, and occupational hazards, and so on-epidemiologic investigation is difficult and challenging. Despite this complexity, it is reassuring that a wealth of new knowledge has been generated by epidemiologic studies over the last few decades. This knowledge now lays the scientific ground for primary prevention of many major cancers and other chronic diseases among humans globally.
Bone biology research in the course of the earlier twenty years resulted in the invention of signaling pathways and gene expression that correlate with osteopenia. This led to the event of pharmaceutical compounds to mitigate the induce and indications of bone decline. Such as, bisphosphonates can initiate apoptosis in osteoclasts, and functions as an antiresorptive agent resulting in fewer breakdown of bone ...
The results suggest that pharmaceutical compounds or other therapeutic methods that produce elevated levels of TTP in humans may offer an effective treatment for some inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.. ...
A controlled release pharmaceutical preparation comprising a core containing a medicinal compound and a coating layer containing a water-repellent salt and a water-insoluble and slightly water-permeable acrylic polymer having trimethylammoniumethyl group. Said preparation releases a medicinal compound in a sigmoid type dissolution pattern irrespective of the PH of a dissolution medium.
This statistic shows the revenue of the industry »manufacture of pharmaceutical preparations« in Italy from 2011 to 2017, with a forecast to 2023.
Buy Specifications for Pharmaceutical Preparations: 30th Report by World Health Organization(WHO) from Waterstones today! Click and Collect from your local Waterstones or get FREE UK delivery on orders over £20.
This paper provides an overview of the pharmaceutical preparations industry in the United States. It gives a snapshot summary of the industry, with additional sections on its development, organisation and structure, current conditions and leading companies.
This forecast statistic shows the revenue of pharmaceutical preparation manufacture in France from 2008 to 2014, with forecasts up until 2020.
Research on drug metabolism and the associated reactions of chemical toxicity has recently lost a major scientific pioneer. It is with great sadness that we learned of the death of our friend and colleague Jim Gillette on December 26th, 2001. During his scientific career Jim contributed over 300 scientific papers on a wide range of topics related to drug metabolism and the toxicity of xenobiotics and their metabolites. His research interests and contributions were broad-based, and many serve as the foundation for our current knowledge of pharmacology and drug metabolism. These contributions stand as a fitting memorial to this insightful man when the history of research on drug metabolism and toxicology is written.. Jim Gillette was a quiet man; some might even say he was shy. He was born and raised in mid-America where he attended Cornell College in Iowa (Bachelor of Arts in Chemistry) and received an Master of Science and Doctor of Philosophy in Biochemistry from the State University of Iowa. ...
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If required by your instructor, you can add annotations to your citations. Just select Add Annotation while finalizing your citation. You can always edit a citation as well. ...
Conference Series LLC invites all the participants across the globe to attend the World Congress on Biotherapeutics slated on May 25-26, 2017 at Dallas, USA.
Legendary Pharmaceuticals is developing pharmaceutical drugs and gene therapies to slow the aging processes and repair the damage of aging.
Legendary Pharmaceuticals is developing pharmaceutical drugs and gene therapies to slow the aging processes and repair the damage of aging.
A portfolio of solutions to support the pharmaceutical research and development, focusing on drug metabolism and pharmacokinetics (DMPK).
1.1 List of Tables. Table 1: Pharmaceuticals & Healthcare, Global, Deals Summary, Number of Deals and Deal Values (US$ m), May 2016-October 2016 13. Table 2: Pharmaceuticals & Healthcare, Global, Major Deals, October 2016 14. Table 3: Pharmaceuticals & Healthcare, Global, Number Of Deals and Deal Values (%), October 2016 19. Table 4: Pharmaceuticals & Healthcare, Global, M&A, Deals Summary, Number of Deals and Deal Values (US$ m), May 2016-October 2016 21. Table 5: Pharmaceuticals & Healthcare, Global, Top M&A Deals, October 2016 21. Table 6: Pharmaceuticals & Healthcare, Global, M&A, Deals Summary, Number of Deals and Deal Values (US$ m), by Therapy Area, May 2016-October 2016 22. Table 7: Pharmaceuticals & Healthcare, Global, Equity Offerings, Deals Summary, Number of Deals and Deal Values (US$ m), May 2016-October 2016 24. Table 8: Pharmaceuticals & Healthcare, Global, Top Equity Offering Deals, October 2016 24. Table 9: Pharmaceuticals & Healthcare, Global, Equity Offering Deals, Deals ...
In this section: Frequently used names | Names specific to Cochrane | Family names | Pharmaceutical drug names | Organism names | Virus names | Country and ethnic group names Frequently used names
This section includes an alphabetical index to information about specific pharmaceutical drugs and medications. Each drug can be found by its generic and common names. Note that herbal and other non-pharmaceutical medications are listed in the relevant subcategory of Health/Alternative.
We have plenty of evidence, scientific and user feedback on the problems with many pharmaceutical drugs.. Researchers discovered that benzodiazepines can cause dementia after following up with patients for 15 years.[i]. Anti-psychotics used in the treatment of schizophrenia have been found to cause brain shrinkage over time.[ii] Tricyclic antidepressants and antihistamines have been found to cause dementia and contribute to Alzheimers Disease.[iii]. My point in bringing up these findings with prescription pharmaceuticals used to treat everything from Alzheimers to a stuffed-up sinus to insomnia is that they affect neurotransmitters in your brain.. Nootropics often target neurotransmitters in your brain as well. Altering neurotransmitters and neurotransmission is serious business. And can have equally serious consequences if were not careful.. For optimal cognition and brain health, your brain maintains a delicate balance of all neurotransmitters. Each works in synergy with another and is ...
Biosynthesis of Metabolites for Use in Drug Metabolism Studies and Lead Diversification. First Session: 10:00 - 11:00 pm EDT. Authentic standards of drug metabolites are valuable reagents for carrying out experiments aimed toward understanding the disposition, efficacy, and safety of drugs. However, obtaining metabolite standards by conventional organic synthesis can frequently be challenging, expensive, and they can take weeks to months to prepare. In this webinar, laboratory procedures used to generate drug metabolites at nanomole scale will be described, and the application of quantitative NMR spectroscopy to determine the amount of product will be shared. These are activities that can be carried out in most drug metabolism laboratories and require only a couple of days. Metabolites obtained using these approaches can be used to test target activity, they can be used as authentic standards for quantitative bioanalysis of in vivo and in vitro samples by HPLC-MS, and they can also be used in ...
Aberrant activation of BRAF signaling has been implicated in the pathogenesis of melanoma (26-28), a deadly form of skin cancer that afflicts millions of people throughout the world. The modulation of BRAF signaling would be a rational approach for the prevention and therapy of melanoma. To identify an inhibitor that can act on multiple kinases in the BRAF-signaling cascade, we screened the FDA drug database to search for a drug molecule that can target kinases of this oncogenic signal transduction pathway. Virtual screening was conducted using the Glide module (22, 23, 29). During ligand-protein docking in virtual screening, each kinase target was treated as a solid object but the drug compound was fully flexible. Each screening process targeted 1 of the 3 kinases, BRAF, MEK1/2, or ERK1/2, of the BRAF pathway and provided a docking scoring of the tested drug molecules and their relative rank in binding affinity with the selected kinase targets. After checking the first 50 drug leads for each ...
Some people are under the belief that pharmaceutical drugs cure illness. This is a flawed assumption. Statins, benzoyl peroxide-containing acne creams, antibiotics, and most other medications that line the shelves of drug stored dont actually cure illness, they merely suppress or cover up symptoms of illness.. Imagine that all of the diseases that are known to affect us humans make up a large forest in which each individual disease represents one tree. Drugs are not capable of stopping this forest from growing. They can cut off or suppress the growth of some branches of certain trees, but in most cases, the trunks of the trees remain sturdy and firmly rooted.. In other words, drugs can suppress some of the manifestations of disease, but they dont eliminate the foundation upon which disease develops. To illustrate this, lets have a brief look at the three medications I mentioned above.. Statins help lower cholesterol levels, but they dont correct the underlying issues that cause elevated ...
Glybera, the worlds first gene therapy drug goes for a whooping €1.1 million ($1.4 million) sale in Germany, and it is the first pharmaceutical drug with the curative therapies to cure faulty genes.
Glybera, the worlds first gene therapy drug goes for a whooping €1.1 million ($1.4 million) sale in Germany, and it is the first pharmaceutical drug with the curative therapies to cure faulty genes.
It should be able to confirm/analyze to the specifications of the material in question & to whatever level of confidence that meets the needs of the intended application of that material e.g. a pharmaceutical drug vs. plant drug or food or other natural products. In other words we dont need to use LC/MS to analyze for the presence or absence of caffeine to determine the identity of coffee if the same results or better/more complete can be derived with something like HPTLC or microscopy. It would be like driving a nail into a piece of wood with a sledge hammer instead of a carpenters hammer or using your Ferrari to drive to the store around the block when you could have easily walked, etc. unless your trying to impress your friends & neighbors. It would be a waste of time, money & energy to use the overkill methods when something else that is sufficient for the intended purpose can do it as well or better in some cases.. A common problem I see facing this industry is the overuse of certain ...
Most people dont know that most pharmaceutical drugs are synthesized compounds from plants anyway. Herbs are more gradual though, you start with small doses to be safe. Before that, you have to know for sure what it is, and AFTER that, you may need a different herb or combination to get the desired effects. I think that ideology doesnt go over too well in our fast-paced society ...
Pharmaceutical drugs containing azithromycin, including Zithronic, Zithroset, Zithroriv, Zithrostat, Zithrovia, Zithrowin; their forms, doses and companies.
MILAN, December 4, 2012 /PRNewswire/ --. Last month, 55 of Europes biggest players from across the pharmaceutical drug discovery sector convened for two-and-a-half days as they attended the most disruptive event of the year - GDS Internationals fourth Next Generation Pharmaceutical Drug Discovery summit (NGP DD EU), held at the Meliá Milano Hotel, Milan, Italy.. Europe has been an enduring force in the pharmaceutical industry for decades. However, increased competition due in part to globalisation, economic recession and ICT advancements has levelled the playing field for drug discovery. Wise investment and innovative new technologies are subsequently proving key to staying ahead of competitors. With this in mind, GDS International has created an award to recognise exceptional talent within the sector.. Selected as the winners by a panel of 20 senior executives from the R&D functions of global biopharma companies, Paul ORiordan - CEO of Synexa Life Sciences, and Henning Steinhagen - SVP Head ...
E.M.J. (Sabeth) Verpoorte has more than 26 years of research experience in the lab-on-a-chip field, starting in 1990 as a postdoctoral researcher and later as staff research scientist in the pioneering lab-on-a-chip group headed by Professor A. Manz at Ciba Ltd., Basel, Switzerland. In July 1996 she assumed the position of team leader in the group of Professor Nico F. de Rooij at the Institute of Microtechnology (IMT), University of Neuchâtel, Switzerland, where her research interests concentrated on the lab-on-a-chip area for bioanalytical and environmental applications. She successfully led a research team of 5 PhD students and 3 postdocs while at IMT.. Sabeth Verpoorte has been head of the Pharmaceutical Analysis Group in the Groningen Research Institute of Pharmacy, University of Groningen, since 2003. Research in the Pharmaceutical Analysis group is devoted to better understanding micro- and nanofluidic systems and how they can be applied to chemical and cell biological problems. A major ...
The aim of this work was to conduct a targeted monitoring study of twelve of the selected pharmaceutical compounds and pharmaceutical compound metabolites at UK sewage treatment works (STW). The occurrence data generated by this targeted monitoring programme will be used to verify the Predicted Environmental Concentrations (PECs) derived during the screening process, reduce the uncertainty associated with the screening process and provide actual data to enable the Environment Agency to better determine potential risk. Analytical methods were developed and validated to determine concentrations of the pharmaceutical compounds trimethoprim, diclofenac, sulfamethoxazole, acetylsulfamethoxazole, paracetamol, mefenamic acid, ibuprofen, erythromycin, dextropropoxyphene, lofepramine, tamoxifen and propranolol in STW effluents and receiving water samples collected over a three month period during 2002. STW final effluent and receiving water samples were collected from Corby, Great Billing, East Hyde, ...
Aim and Scope. International Journal of Farmacia (IJF) is a per-reviewed, online journal that publishes original research manuscripts, review articles in broad specializations of pharmacy. IJF maintains the quality by publishing research articles which have significance in different areas of pharmacy. IJF strives to manage high standards in peer reviewing, rapid publication. IJF concerned with different drug delivery systems, including their design and evaluation.. IJF covers the following areas of Pharmacy:. Pharmaceutics, Industrial Pharmacy, Biopharmaceutics, Pharmacokinetics, Nano-Technology Drug Delivery Systems, Pharmacology, Pharmacognosy, Pharmaceutical Analysis, Medicinal Chemistry, Pharmaceutical Management, Pharmacy practice, Bio-Technology and Natural Product Research.. ...
International Journal of Research in Pharmaceutical Sciences (IJRPS) is quarterly publishing online peer-reviewed scientific journal sponsored by Pharmascope Publications. The journal publishes research articles, review articles, short communications, case studies and reports in Pharmaceutical Sciences.. Coverage Area: Pharmaceutics, Novel Drug Delivery Systems, Pharmaceutical Chemistry and Drug Design, Pharmaceutical Analysis and Quality Assurance, Pharmaceutical Nanotechnology, Pharmacology and Toxicology, Hospital and Clinical Pharmacy, Clinical Research, Clinical Report, Case Studies, Pharmacognosy and Phytochemistry, Chemistry, Natural Products, Medicinal Chemistry, Molecular Biology, Microbiology and Biotechnology, Alternative Medicine, Polymer Science, Industrial Pharmacy, Drug Regulatory Affair, Intellectual Property Rights (IPR), Molecular Modeling, Herbal Medicines, Dental Medicines, Paramedical and Lifesciences.. ...
A therapeutic deep eutectic system (THEDES) is here defined as a deep eutectic solvent (DES) having an active pharmaceutical ingredient (API) as one of the components. In this work, THEDESs are proposed as enhanced transporters and delivery vehicles for bioactive molecules. THEDESs based on choline chloride (ChCl) or menthol conjugated with three different APIs, namely acetylsalicylic acid (AA), benzoic acid (BA) and phenylacetic acid (PA), were synthesized and characterized for thermal behaviour, structural features, dissolution rate and antibacterial activity. Differential scanning calorimetry and polarized optical microscopy showed that ChCl:PA (1:1), ChCl:AA (1:1), menthol:AA (3:1), menthol:BA (3:1), menthol:PA (2:1) and menthol:PA (3:1) were liquid at room temperature. Dissolution studies in PBS led to increased dissolution rates for the APIs when in the form of THEDES, compared to the API alone. The increase in dissolution rate was particularly noticeable for menthol-based THEDES. ...
Biotherapeutic products (biotherapeutics) have a successful record in treating many life-threatening and chronic diseases. However, their cost has often been high, thereby limiting their access to patients, particularly in developing countries. Recently, the expiration of patents and/or data protection for the first major group of originators biotherapeutics has ushered in an era of products that are designed to be "similar" to a licensed originator product. These products rely, in part, for their licensing on prior information regarding safety and efficacy obtained with the originator products. The clinical experience and established safety profile of the originator products should contribute to the development of similar biotherapeutic products (SBPs). A variety of terms, such as "biosimilar products", "follow-on protein products" and "subsequent-entry biologics" have been coined by different jurisdictions to describe these products.. The term "generic" medicine is used to describe chemical, ...
TY - JOUR. T1 - Pharmaceutical residues in wastewater treatment works effluents and their impact on receiving river water. AU - Zhou, J. L.. AU - Zhang, Z. L.. AU - Banks, E.. AU - Grover, D.. AU - Jiang, JiaQian. N1 - Originally published in: Journal of Hazardous Materials (2009), 166 (2-3), pp.655-661.. PY - 2009/7/1. Y1 - 2009/7/1. N2 - Various pharmaceutical residues are being discharged from wastewater treatment works (WTW) effluents, the impact of which on river water quality is of high relevance to environmental risk assessment. The concentrations of eleven pharmaceutical compounds were determined in three WTWs in England, and the river Ouse receiving effluents fromScaynes HillWTW. Results showthat five compounds propranolol, sulfamethoxazole, carbamazepine, indomethacine and diclofenac were detected in all wastewater and river water samples, with carbamazepine showing the highest concentrations (up to 2336 ng L-1) in WTW influent. Different compounds were removed to different extent in ...
Spermaceti, obtained primarily from the spermaceti organ, and sperm oil, obtained primarily from the blubber in the body, were much sought after by eighteenth, nineteenth, and twentieth century whalers. These substances found a variety of commercial applications, such as candles, soap, cosmetics, machine oil, other specialised lubricants, lamp oil, pencils, crayons, leather waterproofing, rust-proofing materials and many pharmaceutical compounds.[202][203][204][205] Ambergris, a solid, waxy, flammable substance produced in the digestive system of sperm whales, was also sought as a fixative in perfumery. Prior to the early eighteenth century, hunting was mostly by indigenous Indonesians.[206] Legend has it that sometime in the early eighteenth century, around 1712, Captain Christopher Hussey, while cruising for right whales near shore, was blown offshore by a northerly wind, where he encountered a sperm whale pod and killed one.[207] Although the story may not be true, sperm whales were indeed ...