We have observed that autoantibodies reactive with important phospholipid antigens are present in the sera and gingival crevicular fluids of patients with periodontitis. The antibodies are likely induced by commonly occuring plaque bacteria. Phosphorylcholine (PC) is a prevalent antigen found on 30-40% of plaque bacteria, and patients with periodontal attachment loss have significantly higher concentrations of IgG anti-PC than do individuals without attachment loss. Data indicate that these antibodies bind to and opsonize oral microorganisms such as Actinobacillus actinomycetemcomitans (A. actinomycetemcomitans) and further that they react with and opsonize modified low-density lipoproteins (LDL). Anti-β2-glycoprotein 1-dependent anti-cardiolipin (anti-CL), another antibody of interest, is found at elevated levels in 15-20% of patients with generalized periodontitis. In patients with systemic lupus erythemathosis (SLE) or the antiphospholipid syndrome (APS) elevated levels of these antibodies ...
For this review of professional mechanical plaque removal 19 studies were identified. While benefits were shown for an number of outcomes; tooth loss; clinical attachment; pocket depth and bleeding on probing the impact on long-term tooth survival and stability of periodontal parameters has still to be assessed. [read the full story...] ...
IMI Ireland organized a clinical attachment for Dr Muthanna Abid, an Iraqi native from Najaf. Dr Abid works at the University of Kufa as a full time Urologist. He came to Galway, Ireland for a 21 day clinical attachment, commencing from the 20th January to 17th February, 2011.. Dr Syed Qasim Jaffry pieced together a rigorous working day programme for each day Dr Abid remained in Galway. Dr Abid rotated out of Galways three main hospitals, in each of these he got to see a number of Urological cases, these consisted of. ...
TY - JOUR. T1 - Relationship of metabolic syndrome to periodontal disease in Japanese women. T2 - The Hisayama study. AU - Shimazaki, Y.. AU - Saito, T.. AU - Yonemoto, K.. AU - Kiyohara, Y.. AU - Iida, M.. AU - Yamashita, Y.. PY - 2007/3/1. Y1 - 2007/3/1. N2 - Recent studies have suggested that several systemic conditions - such as obesity, hypertension, hyperlipidemia, and diabetes - are related to periodontitis. The objective of this study was to examine the relationship between periodontitis and 5 components of metabolic syndrome-abdominal obesity, triglyceride level, high-density lipoprotein cholesterol level, blood pressure, and fasting blood sugar level - in 584 Japanese women. In multivariate analyses, persons exhibiting more components of metabolic syndrome had significantly higher odds ratios for a greater pocket depth and clinical attachment loss than did those with no components; the odds ratios for a greater pocket depth and clinical attachment loss of the persons exhibiting 4 or 5 ...
Publications as of October, 2007:. Genco RJ. Grossi SG. Ho A. Nishimura F. Murayama Y. A proposed model linking inflammation to obesity, diabetes, and peridontal infections. Journal of Periodontology. 76(11 suppl):2075-84, 2005 Nov. Wactawski-Wende J. Hausmann E. Hovey K. Trevisan M. Grossi S. Genco RJ. The association between osteoporosis and alveolar crestal height in postmenopausal women. Journal of Periodontology. 76(11 Suppl):2116-24, 2005 Nov.. Nevins M. Giannobile WV. McGuire MK. Kao RT. Mellonig JT. Hinrichs JE. McAllister BS. Murphy KS. McClain PK. Nevins ML. Paquette DW. Han TJ. Reddy MS. Lavin PT. Genco RJ. Lynch SE. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. [see comment]. Journal of Periodontology. 76(12):2205-15, 2005 Dec. Tezal M. Scannapieco FA. Wactawski-Wende J. Grossi SG. Genco RJ. Supragingival plaque may modify the effects of subgingival bacteria on attachment loss. ...
Imagine if an exterminator informed you, after inspecting your house, that you had isopterans. What would you ask next? Lets assume the exterminator noticed a puzzled look on your face, so he explained in detail the taxonomy subclass of gnathamitermes magnoculus.. Would you now feel less confused and possibly motivated to take action? Or, would you start looking for a new exterminator, preferably someone with a smaller vocabulary?. If only the person had said you had termites, then you be ready to take action. Then you would have understood the magnitude of the situation. But if you do not understand the service that is offered, how can you purchase that service?. A similar scenario occurs in dental practices when patients are diagnosed with gum disease. When patients hear phrases such as "periodontal disease," "scaling and root planing," and "perio maintenance" they are lost. And when patients endure explanations about deep pockets, sub-gingival calculus, and attachment loss they feel much ...
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In cases of advanced periodontal disease, non-surgical or surgical periodontal therapy may lead to poor aesthetics in the anterior regions of the dentition. This may be avoided by applying regenerative periodontal procedures by which the lost periodontal attachment in the bone defects can be restored. The indication for regenerative periodontal therapy is therefore often based on aesthetic considerations or on the fact that it may improve the long-term prognosis of individual teeth. The following materials are commonly used for regenerative procedures: Emdogain Gel, synthetic membranes, porcine derived membranes, synthetic or bovine derived graft materials.. ...
Methods 203 subjects aged 48-84 years old were cross-sectionally surveyed. All participants underwent oral examination. Age, gender, education level, regular exercise, smoking were evaluated through interview. Periodontal health status was evaluated by clinical attachment loss over 6 mm (CAL6 mm) for 6 points of 12 index teeth (total 72 sites). The number of CAL6 mm sites was counted. Unstimulated saliva was collected for 10 min. Salivary NO was determined by the Griess reagent. ANCOVA and Multiple linear regression analyses were applied. ...
Tooth loss and subsequent ridge collapse continue to burden restorative implant treatment. Careful management of the post-extraction tissues is needed to preserve the alveolar ridge. In-lieu of surgical augmentation to correct a ridge defect, the socket-shield technique offers a promising solution. As the root submergence technique retains the periodontal attachment and maintains the alveolar ridge for pontic site development, this case report demonstrates the hypothesis that retention of a prepared tooth root section as a socket-shield prevents the recession of tissues buccofacial to an immediately placed implant. The socket-shield technique is a highly promising addition to clinical implant dentistry and this case report is among the first to demonstrate the procedure in clinical practice with a 1-year follow up.. ...
DOI: 10.11607/prd.2630 Gingival recession is defined as an apical displacement of the gingival margin beyond the cementoenamel junction leading to serious consequences, including exposure of the root surface, loss of periodontal attachment, root sensitivity to hot and cold air, and esthetic problems. The aim of this study was to evaluate the long-term effect of pedicled buccal fat pad (PBFP) alone and with Emdogain in covering severe gingival recession defects and restoring tooth function. A total of 10 severe buccal recession defects in maxillary first molars were selected to be treated with PBFP, with Emdogain (group I; n = 5) or alone (group II; n = 5). Probing depth, clinical attachment level, depth of the gingival recession, width of the keratinized gingiva, and tooth mobility were recorded and statistically analyzed at baseline and during follow-up recalls until 2 years postoperatively. At 2 years, the percentage of root coverage was 60.18% and 59.07% for group I and group II, ...
Systemic infection and/or inflammation has been related with an increased risk of brain abscesses, cerebrovascular disease, cognitive impairment and other pathological states of the brain. Therefore, it is plausible, that a chronic infection and inflammation disease, such as periodontitis, may affect the central nervous system (CNS). Chronic periodontal disease is a condition that causes breakdown of the supporting tissues of the teeth, alveolar bone and soft tissues. Chronic periodontitis is a multifactorial disease caused by dental plaque composed of pathogenic bacteria that triggers the immune response in susceptible hosts. Oral pathogenic bacteria is a source of chronic infection that can induce local and peripheral production of pro-inflammatory cytokines such as IL-1ß, IL-6 and TNF- , inflammatory mediators, as well as bacterial products such as lipopolysaccaride endotoxin. Viruses, such as herpes and Epstein-Barr, can also be found in periodontal pockets. It is well established that oral ...
About one out of three persons living in the United States has periodontal disease [1]. Periodontal disease is more severe among African Americans, Hispanics, and men [1]. Periodontal health has an established clinical relationship with chronic systemic conditions like diabetes, cardiovascular disease, and obesity, and periodontal treatment has been shown to improve dental health as well as general health. Basic periodontal treatment starts with home care and scaling and root planing, the treatment of choice for patients with mild-to-moderate periodontitis with clinical attachment loss equal to or greater than 4mm [2].. The 2010 Affordable Care Act represents the most significant overhaul of the U.S. healthcare system since 1965, when the New Deal Social Security Act was amended by the introduction of Medicare and Medicaid. Generally understood, Medicare is hospital and general medical insurance for senior citizens paid for by a Federal employment tax over the working life of the retiree. The ...
Objectives: The aim of the present cross-sectional study was to investigate the association between serum glycosylated haemoglobin (HbA1c) levels and periodontal status in patients with periodontitis (CP) and periodontally healthy controls. Furthermore, the objectives were to determine if the periodontitis influenced the serum HbA1c levels. Materials and methods: A total of 93 patients with CP and 95 periodontally healthy subjects were enrolled in the present study using a cross-sectional design. At baseline, patients were examined and characterized on a regular basis for blood serum parameters and non-fasting blood samples levels. In all patients, a full periodontal examination was performed and clinical attachment loss (CAL) was the primary outcome variable chosen. The spearman correlation, a stepwise multivariable linear regression, and Jonckheere-Terpstra tests were applied in order to assess the relationship between HbA1c levels and periodontitis. Results: Patients in the CP group presented ...
Differing theories of the nature of periodontal disease progression have been proposed, but there is no convincing statistical evidence with which to choose between them. Three models for disease progression are developed, and their covariance structures are derived and shown to be hierarchical. The estimation of the covariance structures of...
TGF-ß1 is a pleiotropic cytokine that exerts its effects on bone and connective tissue metabolism which are of great importance in periodontal diseases. The expression of TGF-ß1 has been shown to be under genetic control. Two SNPs at codon 10 (L10P) and codon 25 (R25P) represent functionally important genetic variants. Therefore, the aim of this study was to evaluate links between genetic variants of TGF-ß1 and chronic/aggressive periodontitis and its clinical features. Patients and methods: One hundred and forty nine periodontitis patients (chronic: n=68, mean age=48.9+9.6y, 64.2% females; aggressive: n=81, mean age=40+9.5y, 63% females) and 82 healthy controls (mean age=46.6+10.7y, 53.7% females) without periodontitis were included in the study. TGF-ß1 polymorphisms and haplotypes were determined using PCR-SSP (CTS-Kit, Heidelberg, Germany). The clinical investigation included smoking status, plaque (API) and bleeding indexes (BOP), pocket depth (PD) and clinical attachment loss (CAL). ...
Detail of the period when the root sheath cells (blue) secrete enamel matrix proteins. Following formation of the protein matrix on the surface of the mineralizing dentin, cementoblasts (Red) start producing cementum (Light blue) which anchors collagen fibers.. The Next Generation. In the mid 1980s, a revolutionary breakthrough in the basic biology of tooth development took place at the Karolinska Institutes department of Oral Pathology in Stockholm. The discovery revealed a native complex of enamel matrix proteins and the key if not crucial , role they play in the development of tooth-supporting tissues. These enamel related proteins mediate the formation of acellular cementum on the root of the developing tooth, providing a foundation for all of the necessary tissues associated with a functional periodontal attachment.. This groundbreaking discovery has fueled the development of a new generation in periodontal therapy, and makes the recreation of lost tooth support an attainable goal in the ...
Bacterial plaque is the cause of gingivitis, which acts to initiate the bodys host response. This can result in the destruction of the gingival tissues which may progress to the destruction of the periodontal attachment apparatus. The plaque accumulates within the small gaps located between teeth, in the gingival grooves and in other areas known as plaque traps. Plaque traps can include bulky and overhanging restorative margins, clasps of removable partial dentures and tartar that forms on the teeth over time. Although these accumulations may be small, the bacteria in them produce chemicals that trigger an inflammatory response in the gum tissue. This inflammation can result in an enlargement of the gingiva and subsequent formation. ...
Download Free Full-Text of an article EVALUATING SALIVARY ALKALINE PHOSPHATASE LEVELS AS A BIOCHEMICAL MARKER OF PERIODONTAL DISEASE IN PERIODONTAL PATIENTS IN A TERTIARY HOSPITAL IN NIGERIA
BACKGROUND AND OBJECTIVE Neutrophils are the primary white blood cells that are recruited to fight the initial phases of microbial infections. While healthy norms have been determined for circulating blood neutrophil counts in order to identify patients with suspected systemic infections, the levels of oral neutrophils (oPMNs) in oral health and in the presence of periodontal diseases have not been described. It is important to address this deficiency in our knowledge as neutrophils are the primary immune cell present in the crevicular fluid and oral environment and previous work has suggested that they may be good indicators of overall oral inflammation and periodontal disease severity. The objective of this study was to measure oPMN counts obtained in a standardized oral rinse from healthy patients and from those with chronic periodontal disease in order to determine if oPMN levels have clinical relevance as markers of periodontal inflammation. A parallel goal of this investigation was to introduce
Two Israeli doctors - one a periodontal specialist, the other a fertility specialist - studied 56 men over the course of three years. The men had all visited a fertility clinic to have their sperm counts analyzed.. The subjects also received periodontal examinations. Overall, they had poor gum health. Only 13% had healthy gums. Fully 50% suffered from gingivitis, with 32% having chronic periodontal disease and 5% aggressive periondontitis.. Half of the men with zero sperm counts had chronic gum disease. Of the subjects with low sperm counts, 2 out of 3 had gingivitis; by contrast, only 1 out of 2 subjects with normal sperm counts had gingivitis.. Gum disease has already been linked with a host of other health problems ranging from heart disease to diabetes. Why not add one more to the list?. Read more. ...
It is now safe to continue Johns treatment. During the Oral exam the following items were noted: bilateral mand tori, fordyce granules, a dark brown, slightly elevated solid mass with well defined borders adjacent to the commissure of the left lip, multiple chicken pox scars and leukoplakia along the midline of the buccal mucosa ...
This multicenter clinical study will investigate biomarkers of periodontal disease progression. The study will enroll 375 subjects with periodontal disease and 125 periodontally healthy subjects. All subjects will be monitored clinically and have samples taken every 2 months for 12 months for analysis of inflammatory and immunological biomarkers and microbial species. Subjects displaying periodontal disease progression greater than an established threshold will receive periodontal rescue therapy at progressing periodontal sites and continue with monitoring. Periodontally healthy subjects and non-progressing sites in subjects with periodontal disease will serve as controls. After 12 months, subjects with periodontal disease will receive periodontal therapy consisting of 4 quadrants of scaling and root planing. Periodontally healthy subjects will receive prophylaxis and scaling and exit the study. Following periodontal therapy, subjects with periodontal disease will be followed for a maintenance ...
Periodontitis is common, but aggressive periodontitis (AgP) is thought to progress faster than chronic periodontitis (CP). Reviews suggest that tooth loss as a result of periodontitis is in the order of 1.5-9.8%. The aim of this current review was to investigate tooth loss and disease progression in aggressive periodontitis cases. The Medline and Embase databases [read the full story…]. ...
Twelve patients (7 male and 5 female), between 28-46 years old, with moderate to severe periodontitis, light- or non-smokers, and displaying a total of 26 deep intrabony defects, were treated either with a combination of α-TCP (BioBase® α-pore Biovision GmbH., Ilmenau, Germany) and an oily Calcium Hydroxide suspension (Osteoinductal®, Osteoinductal GmbH, Muenchen, Germany) or with the α-TCP alone. All patients underwent initial therapy one month prior to surgery. All patients were instructed and motivated to maintain a good oral hygiene level, verified by a reduction of the PI (Silness and Löe) , 1. Before surgery and six months after, the following clinical parameters were registrated: the periodontal pocket depth (PD), the gingival recession (GR) and the clinical attachment level (CAL). All measurements were performed with a rigid periodontal probe (PCP 12, Hu-Friedy), at six sites per tooth (buccal: mesiobuccal, central, distobuccal; oral: mesiooral, central, distooral). Radiographic ...
This review examines literature data concerning the bacterial findings in chronic periodontitis depending on pocket depth, and presents the latest published information on the presence of proinflammatory factors in periodontal environment. It has been found that chronic periodontitis affects as much …
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It is also becoming more commonly recognized that chronic periodontitis may occur simultaneously with both localized and generalized forms of aggressive periodontitis
Periodontal diseases result in the inflammation of the supporting structures of the teeth, thereby leading to attachment loss and bone loss. One of the main etiological factors responsible for this condition is the presence of subgingival biofilms, comprising microorganisms, namely bacteria, viruses, and fungi. Candida species is one of the fungi reported to be found in periodontal disease which is suggestive of the presence of an association between these variables. The aim of this systematic review was to evaluate the association of Candida species with periodontal disease and determine the prevalence of these species in the patients affected with this disease. The articles related to the subject of interest were searched in several databases, including the PubMed, Web of Science, Google Scholar Medline, Embase, Cochrane Library, and Scopus. The search process was accomplished using three keywords, namely Candida species, Chronic periodontitis, and Gingivitis. All the identified studies
This multi-center study of the Laser Assisted New Attachment Procedure (LANAP protocol) using the FR Pulsed Nd:YAG laser compared to Scaling and Root Planing alone, Modified Widman Flap (MWF) surgery, and Coronal Debridement (CD) alone will utilize a single-blind, four-quadrant split-mouth design with MWF as the positive control, CD as a weak positive control and SRP as the standard treatment control. The study will be conducted at three (3) to five (5) investigational centers. Subjects will receive the Laser Assisted New Attachment Procedure (LANAP protocol) using the pulsed FR Nd:YAG laser, Scaling and Root Planing alone, Modified Widman Flap surgery, and Coronal Debridement alone each in one quadrant of their mouth at Baseline. Treatment modalities are randomly assigned to quadrants at the time of treatment.. Efficacy evaluations, including clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) will be performed at Baseline, month 6, and month 12 using a Florida ...
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Abstract In this paper, we discussed the effect of cone beam CT in assessing the therapeutic effects of Er:YAG laser with guided tissue regeneration (GTR)on furcation involvements of mandibular molars. 30 patients with furcation involvement of mandibular molars (degree Ⅱ) were divided randomly into group C (treated with GTR alone) and group L (treated with Er:YAG laser combined with GTR). Sulus bleeding index (SBI), gingival recession (GR), keratinized gingival (KG), probing pocket depth (PPD), horizontal clinical attachment loss (CAL-H), vertical clinical attachment loss(CAL-V) and cone beam CT measurement indexes such as vertical bone loss (BL-V), horizontal bone loss (BL-H) were observed and compared between the two groups. The results showed that SBI decreased and GR increased in both groups (P,0.05) one year after surgery. PPD, CAL-H and CAL-V decreased in both groups (P,0.05),the changes of group L were greater than those of group C (P,0.05). There were no statistical differences in the ...
in European Journal of Oral Implantology (2015), 8(3), 233-244. PURPOSE: To evaluate the effectiveness of a bone substitute covered with a resorbable membrane versus open flap debridement for the treatment of periodontal infrabony defects. MATERIALS AND METHODS ... [more ▼]. PURPOSE: To evaluate the effectiveness of a bone substitute covered with a resorbable membrane versus open flap debridement for the treatment of periodontal infrabony defects. MATERIALS AND METHODS: Ninety-seven patients with one infrabony defect, which was 3 mm or deeper and at least 2 mm wide were randomly allocated either to grafting with a bone substitute covered with a resorbable barrier (BG group) or open flap debridement (OFD group) according to a parallel group design in five European centres. Blinded outcome measures assessed tooth loss, complications, patients satisfaction with treatment and aesthetics, changes in probing attachment levels (PAL), probing pocket depths (PPD), gingival recessions (REC), ...
Inflammation of the supporting tissues of the teeth characterized by apical migration of the junctional epithelium, loss of periodontal attachment, and loss of alveolar bone. The clinical features include purplish-red swollen (oedematous) and shiny gingival tissue, detachment of the interdental papillae, an increase in the gingival crevice (sulcus) beyond 3mm (periodontal pocket), usually no pain or discomfort, and bleeding on gentle probing. There may also be exudation of pus on digital pressure or probing, tooth mobility, drifting of the teeth, tooth loss, and gingival recession. Subgingival calculus is frequently present and causes additional irritation. The initiation of chronic periodontitis is thought to be due to gene polymorphism, which causes a change in the behaviour of cytokines, substances which influence the immune system. Histologically there is extensive destruction of collagen tissue and there may be fibrosis of the tissue outside the inflamed area. Many bacterial species have ...
|i|Background/Purpose. |/i|Chronic periodontitis is an inflammatory disease of gums that causes loss of supporting structures of teeth, that is, gingiva, periodontal ligament, cementum, and alveolar bone. Levels of various cytokines in the serum, gingival tissues, and gingival crevicular fluid in patients with chronic periodontitis have been studied, but limited data are available on the level of cytokines in saliva. Therefore, a study was designed to determine levels of salivary IL-6 and IL-17 in patients with calculus associated chronic periodontitis.|i| Materials and Methods.|/i| It was a comparative, cross-sectional study that is comprised of 41 healthy controls and 41 calculus associated chronic periodontitis patients (CP patients). According to the degree of attachment loss, CP patients were subcategorized as mild (CAL 1-2 mm), moderate (CAL 3-4 mm), and severe (CAL > 5 mm) forms of periodontitis. Salivary levels of IL-6 and IL-17 were determined using enzyme-linked
Our understanding about periodontal disease progression improved tremendously during 1960s, when animal and human experiments demonstrated the role of bacteria in the initiation of gingivitis and periodontitis 1, 2. These studies led to the proposal of the model of bacterial etiology of periodontal disease. Further investigations in this field led to the advancement of our knowledge of pathogenic bacteria causing disease progression. Specific Gram-negative, anaerobic, or microaerophilic bacteria were implicated in the causation of periodontitis 3-7. During late 1970s and early 1980s protective and destructive roles of the immunoinflammatory responses were described in health and disease 8-14.. Most of the models of periodontal disease progression in the late 1980s stated that specific bacteria initiated the disease process by activating host responses, which were protective and destructive. The actual destruction of connective tissue and bone resulted primarily from inflammatory chemical ...
Student t-test was performed for all the obtained results. In the Aloe vera group, comparison of baseline PCR and after 3 month results showed reduction only in P. gingivalis (p=0.001), where as statistically significant reduction in all the three red complex microorganisms was seen in propolis group. All the clinical parameters (Plaque Index, Gingival Index, Bleeding on Probing, Probing pocket Depth, and Clinical Attachment Level) in both the groups showed statistically significant reductions after 3 months ...
Unfortunately, catching periodontal disease early on is easier said than done, as it starts under the gumline, and even as it develops, 50 percent occurs below the gumline, where it cant be seen by the naked eye. By the time obvious symptoms occur, such as bad breath or a loose tooth, significant damage has already taken place. Treatment methods vary. If the disease is still in its early stages, the treatment will be centered around preventing attachment loss and controlling the plaque. If the disease has advanced enough, more intensive methods, like periodontal splinting or bone replacement procedures, may be necessary. When it comes to periodontal disease, your best option is prevention, and that involves regular brushing and a healthy oral hygiene routine.. ...
Many studies have looked at the link between periodontitis and heart disease. While there is not enough evidence to say that periodontitis causes hear
Periodontal health is a crucial component of your oral and overall health. If neglected, you may experience the severe consequences of the periodontal (gum) disease.
The effectiveness of local delivery of ofloxacin using controlled-release strips (PT-01) in periodontal patients. Part 1. PT-01 application among treatment plans for periodontal disease.:Part 1. PT-01 Application among Treatment Plans for Periodontal Disease (1989 ...
What is Periodontal Disease Periodontal disease (PD) is the most common disease seen and diagnosed in adult dogs and cats. By 3-years-of-age most dogs and cats
Periodontal disease is diagnosed by your dentist or dental hygienist during a periodontal examination. Book an exam today with our dentists in Brighton.
Periodontal disease, also known as Gingivitis, is basically a receding gum line. This is kind of like guys who have receding hairlines, people get receding…. ...
wikiHow has Periodontal Diseases how to articles with step-by-step instructions and photos. How to instructions on topics such as Gum Disease, Gingivitis and more.
This one-day course will provide you with the knowledge to assist your patients. It is an overview of current, evidence-based concepts and treatment plans covering basic principles, systemic implications of periodontal disease, treatment planning and non-surgical through to surgical needs ...
Taking care of your fur kids teeth and gums is important for their overall health and wellbeing. Learn more about periodontal disease in dogs!
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MEDIA has capitalized on the misery of victims of periodontal disease with the dissemination of misleading notions and wholly inaccurate information .