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ANA (Antinuclear Antibody) measurement Anti-cyclic citrullinated peptide antibody level Erythrocyte sedimentation rate measurement Rheumatoid factor measurement Serum C reactive protein level Serum uric acid measurement Medical Tests Analyzer labtest bloodtest What does the test result mean?
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International Journal of Rheumatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on paediatric and adult rheumatological and musculoskeletal conditions, including topics such as basic research, therapy, surgery, and imaging.
Background/Purpose: Autoantibodies to cyclic citrullinated peptide (CCP) are present years prior to the onset of clinical RA. This observation was based on blood bank samples from individuals who later developed RA as well as prospective research studies in European arthralgia clinics. To expand the understanding of the association and timing of future RA in CCP+ individuals, we investigated the risk of progression to RA in a US hospital-based cohort of patients who were CCP+ without RA at presentation.. Methods: We performed a retrospective cohort study of CCP+ individuals seen at a US tertiary care system between 2003-2016 who were without classifiable rheumatic disease including RA per 2010 ACR/EULAR criteria by medical record review within one month of initial positive CCP. Incident RA by ACR/EULAR criteria and date of diagnosis were identified and confirmed independently by two rheumatologists through medical record review. We investigated the risk of progression to RA overall and ...
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Results: Anti-CCP was detected in 16/21 patients with RA group 1 (76%), 7/8 patients with HCV and RA Group 2 (87.5%), 3/11 patients with HCV undifferentiated arthropathy Group 3 (27%) and 1/10 patients with HCV Group 4 (10%).Anti-CCP was not found in the sera of the healthy controls. Anti-CCP was significantly higher in RA patients group 1 compared to HCV arthropathy patients group 3 and HCV patients group 4 (p,0.05), also it was significantly higher in HCV and RA patients group 2 compared to HCV arthropathy patients group 3 and HCV patients group 4 (p,0.05).The 3 patients with positive Anti-CCP in group 3 with HCV undifferentiated arthropathy, showed significant serum levels (84 units, 126 units and 212 units ) and they are representing most probably early RA cases. Meanwhile the only patient with borderline-positive anti-CCP level (25 units) in HCV Group 4 ,was mostly false-positive result caused by nonspecific binding in the ELISA observed infrequently in patients with mixed cryoglobulinemia ...
A positive result for cyclic citrullinated peptide (anti-CCP) antibodies indicates a high likelihood of rheumatoid arthritis (RA). Anti-CCP antibodies have also been reported in approximately 40% of seronegative RA patients, and, like rheumatoid factor (RF), a positive CCP antibody result indicates an increased likelihood of erosive disease in patients with RA ...
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Introduction:. We and others have previously shown that antibodies against cyclic citrullinated proteins (anti-CCP) precede the development of rheumatoid arthritis (RA) and in a more recent study we reported that individuals who subsequently developed RA had increased concentrations of several cytokines and chemokines years before the onset of symptoms of joint disease. Here we aimed to evaluate the prevalence and predictive values of anti-CCP antibodies of IgG, IgM and IgA isotype in individuals who subsequently developed RA and also to relate these to cytokines and chemokines, smoking, genetic factors and radiographic score.. Methods:. A case-control study (1: 4 ratio) was nested within the Medical Biobank and the Maternity cohorts of Northern Sweden. Patients with RA were identified from blood donors predating the onset of disease by years. Matched controls were selected randomly from the same registers. IgG, IgA and IgM anti-CCP2 antibodies were determined using EliA anti-CCP assay on ...
Methods Antibodies recognising five distinct citrullinated antigens were determined by enzyme-linked immunosorbent assay. Serum samples from 36 individuals who had donated blood before and after disease manifestation were used to investigate the development of citrullinated antigen recognition before disease onset. The association of ACPA reactivities with disease outcome was studied using sera from anti-cyclic citrullinated peptide-2 (CCP2)-positive patients with undifferentiated arthritis (UA) who did or did not progress to RA (UA-RA n=81, or UA-UA n=35). To investigate the ACPA recognition profile in patients with RA over a prolonged period of time, baseline serum samples from 68 patients were compared with samples obtained 7 years later.. ...
Objectives: In this study we tested the diagnostic values of rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) and two different commercial anti-mutated citrullinated vimentin (anti-MCV) kits in the differential diagnosis of rheumatoid arthritis (RA) considering that there might also be substantial differences between the performances of the commercial kits. ...
Results Median baseline COMP was higher in patients with RA [9.8 U/l (interquartile range 8.96, 10.5)] compared with controls [8.3 U/l (IQR 7.84, 8.9); p , 0.001] and remained elevated at 4 years [10.8 U/l (IQR 10.2, 11.7); p , 0.001]. At baseline, anti-CCP-positive patients had lower COMP than anti-CCP-negative patients (p = 0.048). In anti-CCP-positive patients, COMP exhibited a parabolic course over 4 years, while COMP in anti-CCP-negative patients had an almost linear course. In anti-CCP-positive patients, COMP was associated with MRI edema and erosion score, while COMP was correlated with synovitis score in anti-CCP-negative individuals. ...
Cyclic peptides are ring structures that consist of alternating L-and D amino acids. In this thesis, CP 5-10 (six cyclic peptides synthesized by Dr. Juan R. Granja, University of Santiago, Spain, and colleagues) were shown to support Na+ flux in black lipid membranes (BLM) with conductances ranging from 33 to 667 pS. CPs ability to form active ion channels was confirmed with 23Na NMR. The previously proposed mechanism of cyclic peptide ion channel formation was that 6 to 10 flat CP rings stack on top of each other, perpendicular to the phospholipid bilayer (Hartgerink et al., 1995). However, CP-6 and CP-8 are strong dimers that can also function as ion channels as demonstrated in our BLM and 23Na NMR experiments. Therefore, we hypothesized that a dimer of the CPs associating across the membrane was sufficient to form an active ion channel. Our investigations were based on the concentration response of the membrane resistance in BLM. With this approach we were able to confirm the dimeric nature of
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As part of a program investigating cyclic peptides with an internal aromatic hydrophobic scaffold as potential novel anti-bacterial agents, we explored the synthesis of simple tyrosine-based systems. These were prepared via key intermediates containing internal allylglycine and allyltyrosine residues for subsequent ring closing metathesis reactions. Although the resulting anti-bacterial activity against Staphylococcus aureus was modest, this represents a novel and simple route to this class of compounds. One intermediate acyclic dipeptide precursor showed good activity against S. aureus with an MIC of 7.8 µg/mL.
Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › Comment/debate › Research › peer-review ...
Church, Leigh D and Filer, Andrew D and Hidalgo, Esther and Howlett, Katherine A and Thomas, Andrew MC and Rapecki, Stephen and Scheel-Toellner, Dagmar and Buckley, Christopher D. and Raza, Karim (2010) Rheumatoid synovial fluid interleukin-17-producing CD4 T cells have abundant tumor necrosis factor-alpha co-expression, but little interleukin-22 and interleukin-23R expression. Arthritis Research & Therapy, 12 (5). R184. ISSN 1478-6354. Cader, Mohammed Z and Filer, Andrew D and Buckley, Christopher D. and Raza, Karim (2010) The relationship between the presence of anti-cyclic citrullinated peptide antibodies and clinical phenotype in very early rheumatoid arthritis. BMC Musculoskeletal Disorders, 11 (1). p. 187. ISSN 1471-2474. ...
Introduction: It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms. We investigated the impact of human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking on the development of ACPA, as well as in combination with ACPA during the state of quiescent autoimmunity (before the onset of symptoms), on the development of RA. Methods: Blood samples donated to the Medical Biobank of Northern Sweden from individuals prior to the onset of symptoms of RA (n = 370) and after onset (n = 203) and from population-based controls (n = 585) were used. Antibodies against 10 citrullinated peptides, fibrinogen (Fib alpha 561-583, alpha 580-600, beta 62-81a, beta 62-81b, beta 36-52), vimentin (Vim2-17, 60-75), filaggrin (CCP-1/Fil307-324),alpha-enolase (CEP-1/Eno5-21), collagen type II ...
The Axis-Shield Anti-CCP test is a semi-quantitative/qualitative ELISA for the detection of the IgG class of autoantibodies specific to cyclic citrullinated peptide (CCP) in human serum or plasma.
Pasireotide is a multi-receptor ligand somatostatin analogue approved for medical treatment of Cushing’s disease and acromegaly. The liquid-phase total synthesis of pasireotide-a 18-membered cyclic hexapeptide-was achieved by the 3 + 2 + 1 strategy, and the Pro1-Phe6 peptide bond was selected as the final cyclization position. Two key fragments were simply synthesized using N,O-bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester (BSA/NHS) as coupling agents, and processes of the two key fragments were simple without any chromatographic purification. The current synthesis method is easily scalable and produces the target peptide with an overall yield of 15%.
1IM7: Structural and immunological characterisation of heteroclitic peptide analogues corresponding to the 600-612 region of the HIV envelope gp41 glycoprotein.
Inova Diagnostics, a world leader in autoimmune disease diagnostic systems and reagents for the clinical laboratory, is pleased to announce the 510(k) clearance of QUANTA Flash® Rheumatoid Factor (RF) IgM and QUANTA Flash RF IgA assays by the US Food and Drug Administration (FDA). These chemiluminescent assays complement Inova Diagnostics previously cleared QUANTA Flash CCP3 assay that detects anti-citrullinated peptide antibodies (ACPA) and expands the number of FDA-cleared assays available on BIO-FLASH®, a random access chemiluminescent system.. ...
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There is great interest in developing new modes of therapy for atherosclerosis to treat coronary heart disease and stroke, particularly ones that involve modulation of high-density lipoproteins (HDLs). Here, we describe a new supramolecular chemotype for altering HDL morphology and function. Guided by rational design and SAR-driven peptide sequence enumerations, we have synthesized and determined the HDL remodeling activities of over 80 cyclic d,l-α-peptides. We have identified a few distinct sequence motifs that are effective in vitro in remodeling human and mouse plasma HDLs to increase the concentration of lipid-poor pre-beta HDLs, which are key initial acceptors of cholesterol in the reverse cholesterol transport (RCT) process, and concomitantly promote cholesterol efflux from macrophage cells ...
Castro J, Grundy L, Deiteren A, Harrington AM, ODonnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley ...
O teste Anti-CCP Axis-Shield é um método ELISA semiquantitativo/qualitativo para a deteção da classe IgG de autoanticorpos específicos do péptido cíclico citrulinado (CCP) em soro humano ou plasma. A deteção de anticorpos anti-CCP é utilizada para ajudar no diagnóstico da Artrite Reumatoide (AR) quando utilizado em conjunto com outras informações clínicas.
cyclo(glutamyl-leucyl-prolyl-glycyl-seryl-isoleucyl-prolyl-alanyl)cyclo((1-5)phenylalanyl-glycine): a bicyclic peptide; structure given in first source
This study has investigated the effect of rheumatoid factor and anti-cyclic citrullinated peptide positivity on drug survival of abatacept in patients with
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The aim of this study was to evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and immunoglobulin (Ig)A ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first-degree relatives (FDRs). Patients with RA (n = 194) and first-degree relatives unaffected by RA (n = 191) were recruited for analysis of secretory antibodies to second-generation cyclic citrullinated peptides (anti-CCP) in plasma. From a subpopulation (25 RA patients, 21 first-degree relatives and 11 controls), saliva samples were obtained for IgA anti-CCP analysis. The presence of secretory ACPA was compared between subject categories, and related to genetic and environmental risk factors. Secretory ACPA occurred in 37 (19%) plasma samples from patients with RA, but only in two (1%) of FDRs. IgA ACPA in saliva was found in three of 25 (12%) patients with RA, but not in any of the 21 FDRs (, 5%). No significant associations were seen between the presence of secretory ACPA and SE or ...
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Calreticulin (CRT) and citrullinated (citCRT) are implicated in rheumatoid arthritis (RA) pathology. citCRT binds to RA shared epitopes (SE) on HLA-DR molecules with high affinity and triggers pro-inflammatory events in adjacent cells. The aim of the study was to detect the presence of citCRT prior to developing RA and evaluate if citCT is a target for autoantibodies in RA cohorts with and without lung disease. Antibodies were assessed by ELISA against native CRT, citCRT and general protein citrullination, in sera from 50 RA patients without lung disease, 122 bronchiectasis (BR) patients, 52 bronchiectasis patients with RA (BRRA), 87 asthma patients and 77 healthy controls (HC). Serum citCRT was detected by immunoblotting and mass spectrometry. Genomic DNA was genotyped for HLA-DRB1 alleles. Patients were assessed for DAS28, rheumatoid factor, and anti-cyclic citrullinated peptide antibodies. Extracellular citCRT was detected in BR patients sera prior to them developing RA. A citCRT SE binding ...
Anti-cyclic citrullinated peptide (anti-CCP) antibodies are considered to be a marker of rheumatoid arthritis (RA). However, limited and controversial reports concern this problem in children with juvenile idiopathic arthritis (JIA). Objective: To access the prevalence and diagnostic value of...
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There is currently no biochemical test for detection of early-stage osteoarthritis (eOA). Tests for early-stage rheumatoid arthritis (eRA) such as rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies require refinement to improve clinical utility. We developed robust mass spectrometric methods to quantify citrullinated protein (CP) and free hydroxyproline in body fluids. We detected CP in the plasma of healthy subjects and surprisingly found that CP was increased in both patients with eOA and eRA whereas anti-CCP antibodies were predominantly present in eRA. A 4-class diagnostic algorithm combining plasma/serum CP, anti-CCP antibody and hydroxyproline applied to a cohort gave specific and sensitive detection and discrimination of eOA, eRA, other non-RA inflammatory joint diseases and good skeletal health. This provides a first-in-class plasma/serum-based biochemical assay for diagnosis and type discrimination of early-stage arthritis to facilitate improved treatment and patient
The use of cyclic peptides in one-bead-one-compound libraries is limited by difficulties in sequencing hit compounds. Lacking a free N-terminal amine, such peptides cannot be sequenced by the Edman degradation approach, and complex fragmentation patterns are obtained by tandem mass spectrometry. To overcome this problem, we designed an alternative approach introducing a methionine residue within the macrocycle and as a linker to allow simultaneous ring-opening and release from the resin upon treatment with cyanogen bromide. The methionine linker was inverted relative to the peptide chain to allow the synthesis of cyclic peptides anchored by a lysine side chain and to avoid the presence of two C-terminal homoserine lactones on the released linear peptides. After MALDI-TOF MS/MS analysis, the peptides released from a single bead were sequenced manually and with a de novo sequencing software. The strategy described herein is compatible with commonly used amino acids and allows sequencing of cyclic ...
0084] Further, diagnostic markers according to an embodiment of the present disclosure may include one or more of: 1,25 dihydroxy-vitamin D, 17-Hydroxyprogesterone, 25-hydroxy-vitamin D, Antineutrophil Cytoplasmic Antibodies, 5-Hydroxy Tryptamine, 5-hydroxyindoleacetic acid, Acetoacetate, Activated Partial Thromboplastin Time, Adrenocorticotropic Hormone, Alanine aminotransferase, Alanine transaminase, Albumin, Albumin-to-Creatinine ratio, Albumin/Globulin ratio, Alcohol, Aldolase, Aldosterone, Aldosterone and plasma renin activity, Aldosterone and Renin, Alkaline Phosphatase, Allergen-specific IgE, Alpha tryptase, Alpha-1 Antitrypsin, Alpha-fetoprotein, Alpha1-antitrypsin, Alzheimer biomarkers (including Tau protein and Amyloid Beta 42 peptides), Amylase, ANCA Antibodies, ANCA/MPO/PR3 Antibodies, Angiotensin-Converting Enzyme, Anti-citrulline antibody, anti-cyclic citrullinated peptide antibody, Anti-retroviral drug resistance testing, anti-ribonucleoprotein, anti-Sjogrens Syndrome A, ...
0077] Further, diagnostic markers according to an embodiment of the present disclosure may include one or more of: 1,25 dihydroxy-vitamin D, 17-Hydroxyprogesterone, 25-hydroxy-vitamin D, Antineutrophil Cytoplasmic Antibodies, 5-Hydroxy Tryptamine, 5-hydroxyindoleacetic acid, Acetoacetate, Activated Partial Thromboplastin Time, Adrenocorticotropic Hormone, Alanine aminotransferase, Alanine transaminase, Albumin, Albumin-to-Creatinine ratio, Albumin/Globulin ratio, Alcohol, Aldolase, Aldosterone, Aldosterone and plasma renin activity, Aldosterone and Renin, Alkaline Phosphatase, Allergen-specific IgE, Alpha tryptase, Alpha-1 Antitrypsin, Alpha-fetoprotein, Alpha1-antitrypsin, Alzheimer biomarkers (including Tau protein and Amyloid Beta 42 peptides), Amylase, ANCA Antibodies, ANCA/MPO/PR3 Antibodies, Angiotensin-Converting Enzyme, Anti-citrulline antibody, anti-cyclic citrullinated peptide antibody, Anti-retroviral drug resistance testing, anti-ribonucleoprotein, anti-Sjogrens Syndrome A, ...
RESULTS: 19.5% of plasmablast-derived antibodies from CCP-positive RA patients, but none from the CCP-negative RA patient or healthy controls, specifically recognized citrullinated antigens. The immunoglobulin genes encoding these ACPAs were highly mutated with increased replacement/silent mutation ratios, suggesting the involvement of active antigen selection in ACPA generation. Interestingly, 63% of the ACPAs cross-reacted with OMAs and/or citrullinated enolase from P. gingivalis. The reactivity of ACPAs against citrullinated proteins from P. gingivalis was confirmed by immuno blot and mass spectrometry. Furthermore, germ-line reversions of some ACPAs completely eliminated their reactivity to citrullinated human antigens but retained their reactivity to P. gingivalis ...
Bottromycin is a macrocyclic peptide with antibiotic activity. It was first discovered in 1957 as a natural product isolated from Streptomyces bottropensis. It has been shown to inhibit methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) among other Gram-positive bacteria and mycoplasma. Bottromycin is structurally distinct from both vancomycin, a glycopeptide antibiotic, and methicillin, a beta-lactam antibiotic. Bottromycin binds to the A site of the ribosome and blocks the binding of aminoacyl-tRNA, therefore inhibiting bacterial protein synthesis. Although bottromycin exhibits antibacterial activity in vitro, it has not yet been developed as a clinical antibiotic, potentially due to its poor stability in blood plasma. To increase its stability in vivo, some bottromycin derivatives have been explored. The structure of bottromycin contains a macrocyclic amidine as well as a thiazole ring. The absolute stereochemistry at several chiral centers has been ...
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this test finds immune system chemicals, called antibodies, that target ccp (cyclic citrullinated peptide), which is present in about 60% to 70% of people with rheumatoid arthritis (ra). you could hav
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Here we describe the identification of the marine depsipeptide sansalvamide A as an inhibitor of MCV topoisomerase. Sansalvamide A inhibited the initial DNA binding by MCV topoisomerase and, consequently, formation of covalent protein-DNA complexes, but did not inhibit religation by the covalent protein-DNA intermediate. This work provides a starting point for possible development of depsipeptide inhibitors for treating MCV infection.. Cyclic peptides such as sansalvamide A are a potent class of naturally occurring bioactive molecules. The immunosuppressant drug cyclosporin is a cyclic peptide secondary metabolite produced by the fungusCylindrocarpon lucidum (Borel et al., 1976). Bacitracin and polymyxin, also cyclic peptides of microbial origin, are in use as topical antibiotic agents (Strohl, 1997). Marine invertebrates are also prolific producers of bioactive cyclic peptides, including the antiviral and cytotoxic molecule didemnin B (Rinehart et al., 1988), the thrombin inhibitor ...
Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients Journal Articles Refereed ...
This study is investigating whether the somatostatin analogue Lanreotide slows progression of polycystic kidney and liver disease in autosomal dominant
Specificity of the assay has been shown by free ligand competition and extensive correlations with other immunological parameters. We show no correlation between anti-BiP and rheumatoid factor or with cyclic citrullinated peptide. We confirm the increased binding of immunoglobulin to BiP in the sera of a group of patients with RA (n = 96) in comparison with controls (n = 96). Our data show a specificity of 71% and a sensitivity of 73% for RA. Furthermore, these data show that antibody will bind to a nonglycosylated form of BiP, since the protein is produced in an Escherichia coli expression system. ...