Materials. The following chemicals and materials were obtained from the indicated companies: RPMI-1640, Dulbeccos Modified Eagles Medium (DMEM) from Gibco BRL, Grand Island, NY, USA; fetal bovine serum (FBS), phtharal (MW=134), melphalan, 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT), phenylmethylsulfonyl fluoride (PMSF) from Sigma Chemical Ind., St. Louis, MO, USA); hydroquinone (MW=110), benzoquinone (MW=108), eugenol (MW=164), dimethylsulfoxide (DMSO) from Wako Pure Chemical, Osaka, Japan; peplomycin sulfate from Santa Cruz Biotechnology, Santa Cruz, CA, USA; 5-fluorouracil (5-FU) from Kyowa, Tokyo, Japan; RNase A, Proteinase K, ethidium bromide, agarose S from Nippon Gene Co., Ltd., Toyama, Japan; DNA molecular marker from Bayou Biolabs, Harahan, LA, USA; 6-well plates, 24-well plates, 96-microwell plates from Becton Dickinson, Franklin Lakes, NJ, USA; substrate of caspase-3, DEVD-pNA (p-nitroanilide) from MBL, Aichi Prefecture, Japan; HuMedia-KG2 from Kurabo, Osaka, ...

Affiliation (based on the past Project Information)：大阪歯科大学,歯学部,講師, Research Field：Surgical dentistry, Keywords：凍結外科,凍結化学療法,Cryochemotherapy,Cryosurgery,凍結手術,抗ガン剤,CDDP,VX2癌,抗癌剤,Peplomycin(PEP), # of Research Projects：2, # of Research Products：0

PFAP protocol: chemotherapy protocol used in treatment of patients with esophageal carcinoma; contains peplomycin, 5-fluorouracil, adriamycin, & cisplatin

VIP regimen 2: chemotherapy protocol consisting of vincristine, ifosfamide and peplomycin for treatment of newly diagnosed stage D2 prostate cancer

Dive into the research topics of Effect of combined therapy using balloon-occluded arterial infusion of cisplatin and hemodialysis with concurrent radiation for locally invasive bladder cancer. Together they form a unique fingerprint. ...

Background: This research was conducted to introduce a patient with rare ovarian mixed germ cell tumor, presented as molar pregnancy. Case Presentation: Th...

The relation of collagen synthesis to experimentally induced arteriosclerosis was studied by measuring proline hydroxylase activity. Gross aortic plaques were produced in rabbits by daily injection of epinephrine (intravenous) and thyroxine (intraperitoneal) for 4, 9, or 14 days. Activity of proline hydroxylase was significantly increased after 4 days of treatment and reached a peak, five- to sixfold increase, after 14 days of treatment. The increase in enzyme activity was correlated with the severity of observed arteriosclerosis. Increase in proline hydroxylase activity may be a possible biochemical defect in the aortas of rabbits with arteriosclerosis induced by injury. ...

A kind of centrifugal model test method inducing landfill body unstability for solution-air, it includes the following steps: step A, one model casing for being placed in geotechnical centrifuge hanging basket is provided, inhalant region and model area are divided by a partition with hole in the model casing, the geotechnical model for simulating msw landfill is set against the partition in the model area, the geotechnical model is made of the sand for being mixed with calcium carbonate；Step B, when the geotechnical centrifuge run to setting G value when, by the geotechnical centrifuge to the inhalant region injection citric acid solution；Step C monitors the unstability situation of the geotechnical model during citric acid solution of the inhalant region penetrates into the geotechnical model by the partition, so that simulating landfill yard rubbish body produces influence of the gas effect to stability.The centrifugal model test method that landfill body unstability is induced for solution

Looking for hexamethylphosphoric triamide? Find out information about hexamethylphosphoric triamide. bempa Explanation of hexamethylphosphoric triamide

As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Induction of cancer specific apoptosis mechanisms. Dear Sirs and Madams,. Sustainable cancer therapy requires new solutions based on new thinking that is fundamentally different from traditional practices.. With these new methods of thinking, the author can postulate a promising route to sustainable cancer therapy. Hereby, cancer-specific membrane receptors are used for the therapeutic application. It is assumed, and there is much to support this contention, that these cancer-specific membrane receptors have structures that are common to all types of cancer.. In this respect, the treatment concept is not only applicable for all types of cancer but also for all stages of development and grading. And both primary tumors and metastases appear equally effectively treatable.. In an effort to understand apoptosis in principle and to reconcile it with the control mechanisms of cell division, the author has succeeded in postulating a therapy concept of cancer via the induction of cancer cell specific ...

other: Study conducted to in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results. ...

Trial drug for treatment of fatigue in MS. Dont know what their other MS drugs are or what phase they are in. MultiCell to Present Companys Portfolio of Novel Drug Candidates at BIO 2006 Conference; Company President Dr. Stephen Chang ...

TY - JOUR. T1 - The transition metal binding properties of a 3RD generation bleomycin analogue, tallysomycin. AU - Greenaway, Frederick T.. AU - Dabrowiak, James C.. AU - Van Husen, Mark. AU - Grulich, Robert. AU - Crooke, Stanley T.. PY - 1978/12/29. Y1 - 1978/12/29. N2 - Employing a number of physical techniques the transition metal binding site of the bleomycin (BLM) related antibiotic tallysomycin (TLM) has been determined. The new antibiotic was shown to have two metal binding sites. One site is similar to that of bleomycin and involves the pyrimidine-imidazole portion of the molecule. The second binding site, which is thermodynamically less stable than the first site, utilizes the amino group of the L-talose moiety and the amino groups located in the β lysine-spermidine portion of the antibiotic. The presence of two metal binding sites and its implication on the mechanism of action of TLM is also discussed.. AB - Employing a number of physical techniques the transition metal binding site ...

Cutroneo, K R. and Liebelt, A G., Elevation of proline hydroxylase activity in spontaneous primary mammary tumors of inbred mice. Abstr. (1972). Subject Strain Bibliography 1972. 300 ...

The mode of cell death of two strains of mouse lymphoma LSI78Y cells was studied following photodynamic therapy (PDT) sensitized by chloroaluminum phthalocyanine. Strains LY-R and LY-S differ in their relative sensitivities to UVC radiation, X-radiation, and PDT; both responded to PDT by undergoing apoptosis. The DNA was degraded into fragments with lengths which are multiples of approximately 180-190 base pairs (i.e., oligonucleosome size), a biochemical marker of apoptosis. The DNA fragmentation was dose and time dependent which indicates this response to be an enzymic process related to cell killing. Cycloheximide, a protein synthesis inhibitor, and actinomycin D, an RNA synthesis inhibitor, enhanced the endonucleolytic DNA fragmentation. Transmis sion electron microscopy revealed chromatin condensation around the periphery of the nucleus, which is also characteristic of apoptosis. The induction of apoptosis in L5178Y cells by PDT was rapid, with marked degradation of DNA occurring in as ...

Hydroxyproline and hydroxylysine are not utilized for collagen synthesis by smooth muscle cells as well as by fibro-, chondro-, osteoblasts and other collagen synthesizing cells. First, the peptide...

Pyrazoles, thiazoles and fused thiazoles have been reported to possess many biological activities. 3-Methyl-5-oxo-4-(2-arylhydrazono)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a,b (obtained from the reaction of ethyl 3-oxo-2-(2-arylhydrazono)butanoates 1a,b with thiosemicarbazide) could be transformed into a variety of thiazolyl-pyrazole derivatives 6a-h, 10a-c, 15a-c, 17, 19 and 21 via their reaction with a diversity hydrazonoyl chlorides as well as bromoacetyl derivatives. Moreover, the computational studies were carried out for all new compounds. The results indicated that five compounds showed promising binding affinities (10a: − 3.4 kcal/mol, 6d: − 3.0 kcal/mol, 15a: − 2.2 kcal/mol, 3a: − 1.6 kcal/mol, and 21: − 1.3 kcal/mol) against the active site of the epidermal growth factor receptor kinase (EGFR). The cytotoxicity of the potent products 3a, 6d, 10a, 15a, and 21 was examined against human liver carcinoma cell line (HepG-2) and revealed activities close to Doxorubicin standard drug.

E2F is a complex family of transcription factors implicated in different cell fates, including proliferation and apoptosis (Stevens and La Thangue, 2003; Frolov and Dyson, 2004; Polager and Ginsberg, 2008; van den Heuvel and Dyson, 2008). The first family member identified, E2F‐1, physically interacts with the retinoblastoma tumour suppressor protein pRb, which negatively regulates E2F‐1 activity (Bandara and La Thangue, 1991; Zamanian and La Thangue, 1992; Weinberg, 1995; Stevens and La Thangue, 2003; Frolov and Dyson, 2004). While it has been established that E2F‐1 promotes proliferation and therefore is potentially oncogenic, it has also become clear that E2F‐1 is endowed with apoptotic activity (Polager and Ginsberg, 2008; van den Heuvel and Dyson, 2008). Thus, many E2F target genes are connected with apoptosis (Ren et al, 2002), and in Rb−/− mice the enhanced level of tissue‐specific apoptosis reflects deregulated E2F‐1 activity (Tsai et al, 1998; Iaquinta and Lees, 2007). ...

This restaurant for the staff of retail brand Cotton On, located in the brands global headquarters in Geelong, is a sophisticated space created by Greg Natale Design in collaboration with PTID.. A palette of blue, black and green forms a moody brasserie space, presided over by a blue panelled acoustic ceiling, its squares dotted with elegant brass lights. Across black and white marble floors, blue leather chairs and banquettes gather around marble and timber tables. Timber-panelled partitions provide warm tones, with other beautiful finishes courtesy of green and blue glazed tiles around the bar and fluted glass panels.. An attractive outdoor area reminiscent of the iconic Chateau Marmont teams timber with blue tones in comfortable seating among an abundance of plantings, established in collaboration with Myles Baldwin.. Like the building this restaurant occupies, the brands heritage remains a presence throughout its design. The restaurants name references local markets where the client used ...

The effect of the solvent gelation ability of three leaf-like triamide derivatives, having three 12-hydroxystearyl or octadecyl chains, as thixotropic-induced additives was investigated. Furthermore, the clarification of origin of the physical properties of these compounds was carried out by monolayer investigation on the water surface. The solvent gels formed by the addition of these triamide com ...

Buy our human hepatocellular liver carcinoma cell line nuclear lysate, acetaldehyde treated. ab14661 has been validated in electrophoretic mobility shift…

Molecular dosimetry of the chemical mutagen ethyl methanesulfonate. Quantitative comparison of mutation induction in escherichia coli, v79 chinese hamster cells and l5178y mouse lymphoma cells, and some cytological results in vitro and in vivo., C S. Aaron, A A. Zeeland, G R. Mohn, A T. Natarajan, A G. Knapp, A D. Tates, and B W. Glickman. ...

This report describes the effects of the test substance on the induction of forward mutations at the thymidine-kinase locus (TK-locus) in L5178Y mouse lymphoma cells. The test was performed in two independent experiments in the absence and presence of S9-mix (rat liver S9-mix induced by a combination of phenobarbital and ß-naphthoflavone). The test substance was a clear colourless to slightly yellowish viscous liquid. The test substance was dissolved in ethanol. In the first experiment, the test substance was tested up to concentrations of 250 and 425 μg/ml in the absence and presence of 8% (v/v) S9-mix, respectively. The incubation time was 3 hours. The test substance was tested up to cytotoxic levels of 81 and 77% in the absence and presence of S9-mix, respectively. The test substance precipitated in the culture medium at dose levels of 100 μg/ml and above. In the second experiment, the test substance was tested up to concentrations of 235 and 450 μg/ml, but in the absence and presence of ...

Any statements in this press release about MultiCells expectations, beliefs, plans, objectives, assumptions or future events or performance are not historical facts and are forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the Act). These statements are often, but not always, made through the use of words or phrases such as believe, will, expect, anticipate, estimate, intend, plan, forecast, could, and would. Examples of such forward looking statements include statements regarding the timing, design, scope, and anticipated results of our clinical development of MCT-125, and statements regarding expected milestone and royalty payments to Amarin and worldwide sales relating to MCT-125. MultiCell bases these forward-looking statements on current expectations about future events. They involve known and unknown risks, uncertainties and assumptions that may cause actual results, levels of activity, performance or achievements to ...

Here, we analyzed the ability of C. vasculum-derived metabolites to inhibit proliferation, induce cytotoxicity, and trigger apoptotic signaling in NSCLC, SCLC, and ovarian carcinoma. It has previously been shown that compounds isolated from this sponge can kill tumor cells of different origin albeit through unknown mechanism of action (19). We show here that the two acetylenic compounds 1 and 2 as well as the parental mixture of these compounds from which they were separated, indeed cause tumor-specific cytotoxicity in NSCLC and SCLC. Importantly, we demonstrate that for both compounds this cytotoxicity is tumor specific, as all normal cells tested representing heart tissue, bronchial and retina epithelium, normal PBMCs, and foreskin or lung fibroblasts remained unaffected at concentrations that were toxic for NSCLC and SCLC. In ovarian carcinoma cells compound 1 but not compound 2 caused tumor-specific cell death. For compound 2, a cytotoxic effect was evident in NSCLC and SCLC whereas in ...

The major findings of the present study are that water-soluble fullerene directly affects vascular ECs to cause cytotoxic injury or cell death and inhibition of cell growth. To the best of our knowledge, this study provides the first demonstration of the direct effects of water-soluble fullerene on vascular endothelium. In other human cells, including dermal fibroblasts, liver carcinoma cells (HepG2), neuronal astrocytes, and T-lymphocytes (Jurkat cells), recent reports have noted that water-soluble fullerene shows cytotoxic effects, presumably via production of reactive oxygen species (22, 24). Notably, several types of water-soluble fullerene derivatives are available [e.g., hydroxyl fullerene used herein, dendritic C60 monoadduct (22), malonic acid C60 (22) and nano-C60 (24) (basically pristine C60)], and cytotoxicity to cells varies depending on the fullerene subtype used, presumably because of surfactant chemistry, including a balance between hydrophobicity and hydrophilicity (3).. Some ...

New research suggests mitochondria work more like a multicell Tesla electric car battery, with dozens of bioelectric units working as a complex but cohesive unit.

Commonly served as a side salad at your favorite local sushi restaurants it is well worth the few extra dollars on your bill. It is typically served in its green form and is mixed with ginger to create an appealing taste. Harvested in Asia and the U.S. you can feel good about protecting the environment as it has been known to improve coral reef health thereby promoting farming and sustainable agriculture ...

The event was hosted by Cascade Bicycle Club as part of Bike Everywhere Month. As one of our Powerful Partners, Cascade Bicycle Club is the nations largest statewide bicycle nonprofit whose mission is to improve lives through bicycling.. Dozens of employees teamed to ride in to work together from Bellingham, Bothell, Bellevue, Redmond, Ellensburg, and other areas.. Dozens of bicyclists stopped at our stations to grab snacks, giveaways and information about the types of programs we have to offer. In Bellingham, more than 70 people visited our station.. An estimated 30 Bellevue bike commuters stopped at our celebration station to refuel during the two hours we were set up outside our Bellevue Campus. Several people on foot also stopped by to chat and were interested in our Energy Efficiency and Renewables programs. We even had one customer sign-up for a free Home Energy Assessment.. Bike to Work Day is a day to celebrate using an alternative form of transportation. And, its a green form of ...

Before the Fukushima disaster, nuclear power was being rebranded as a green form of energy. New York Times energy reporter Matt Wald explains how the situation in Japan is now raising questions about the safety and disposal of nuclear waste in the U.S.

The occupational hazards presented by hexamethylphosphoric-triamide (680319), responsible for the induction of experimental nasal squamous cell carcinoma in rats, are reviewed briefly. It is estimated that 5,000 workers are occupationally exposed to the compound, most of them in research laboratories. There is no current OSHA standard for hexamethylphosphoric-triamide exposure.

No. Chemical: Phosphorous acid. H Br4(Ionic, molecular, acid, or base) 2). NO2 is a. molecular compound. is HClO4 an acid or base. PCl5 is a. note that this is dissociation ot ionisation because HCl does not have ions. (See Safer Choice Criteria). Synonym: Phosphorous acid tripyrrolidide, Tripyrrolidinophosphine, Tris(N,N-tetramethylene)phosphorous acid triamide Empirical Formula (Hill Notation): C 12 H 24 N 3 P Molecular Weight: 241.31 Classify each chemical compound listed in the table below COMPOUND ( select all that apply) 1). The ions themselves are covalent, not ionic. HCN - Acid NH2- - Base CN- - Base ... H3PO3(l), and H3PO4(l) shown here, determine the # of ionizable protons (acidic hydrogen atoms) per formula unit. in the same way some bases are not ionicv but can produce ions by dissociation e.g. Na2SO4 (sodium sulfate) is an ionic compound. is H2SO3 an acid or base. The post-transition metals often form borderline compounds as well, although the fluorides and oxides in low oxidation ...

Bleomycin- ಉಪಯೋಗಗಳು, ಡೋಸೇಜ್, ಅಡ್ಡ ಪರಿಣಾಮಗಳು, ಪ್ರಯೋಜನಗಳು, ಪರಸ್ಪರ ಕ್ರಿಯೆ ಎಚ್ಚರಿಕೆಗಳನ್ನು ಕಂಡುಹಿಡಿಯಿರಿ

Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,

An N-formamido pyrrole- and imidazole-containing triamide (f-PIP) has been shown by DNase I footprinting, SPR, and CD studies to bind as a stacked dimer to its cognate sequences: 5-TACGAT-3 (5-flank of the inverted CCAAT box-2 of the human topoisomerase IIalpha promoter) and 5-ATCGAT-3. A gel shift experiment provided evidence for f-PIP to inhibit protein-DNA interaction at the ICB2 site. Western blot studies showed that expression of the topoisomerase IIalpha gene in confluent NIH 3T3 cells was induced by treatment with f-PIP. The results suggested that the triamide was able to enter the nucleus, interacted with the target site within ICB2, inhibited NF-Y binding, and activated gene expression.. ...

TWENTY FIVE Aspergillus isolates were screened from Giza Governorate and Saint Catherine Protectorate soils in Egypt. The antimicrobial activity of the crude extracts was tested against two Gram positive bacteria (Bacillus subtilis NRRL-B-4219, Staphylococcus aureus ATCC29213), four Gram negative bacteria (Alcaligenes faecalis B-170, Escherichia coli ATCC25922, Klebsiella pneumoniae ATCC10131, Pseudomonas aeruginosa ATCC27953), and one yeast (Candida albicans ATCC10231). The antioxidant activity using free radical scavenging model was assayed for the crude extracts. The antitumor activity for all of crude extracts was determined against HCT116 (Colon carcinoma cell line), HEPG2 (Liver carcinoma cell line), and MCF-7 (Breast carcinoma cell line). Aspergillus nomius was the most potent fungal species accordingly, it was chosen for bioactivity assay. Identification of this species was further confirmed at the molecular level based on nuclear ribosomal DNA 18s identities. An accession number, LC199488, was

Based on the available in-vivo Mouse micronucleus test (bone-marrow), it can be concluded that Dapsone is not mutagenic in-vivo. This is also confirmed by other in-vitro studies run on Salmonella TA98, TA100, TA 1835, TA 1537 and E. Coli strains WP2 UVRA, WP2 pKM 101 and WP2 uvrA pKM 101, there was no mutagenic effect either with or without activating metabolic system. Under mammalian gene mutation test on tk-locus of L5178 Y mouse lymphoma cells, 4,4 -DDS is not mutagenic in mammalian cells. Nevertheless, under a chromosome aberration study with 4,4-DDS performed according to OECD 473 guideline and GLP principles, in cultured peripheral human lymphocytes in two independent experiments, it is concluded that 4,4-DDS is clastogenic after 3 hours treatment in the absence of S9-mix in human lymphocytes. ...

TY - JOUR. T1 - DNA methylation reduces binding and cleavage by bleomycin. AU - Roy, Basab. AU - Tang, Chenhong. AU - Alam, Mohammad P.. AU - Hecht, Sidney. PY - 2014/9/30. Y1 - 2014/9/30. N2 - In a recent study, we described the enhanced double-strand cleavage of hairpin DNAs by Fe·bleomycin (Fe·BLM) that accompanies increasingly strong binding of this antitumor agent and suggested that this effect may be relevant to the mechanism by which BLM mediates its antitumor effects. Because the DNA in tumor cells is known to be hypomethylated on cytidine relative to that in normal cells, it seemed of interest to study the possible effects of methylation status on BLM-induced double-strand DNA cleavage. Three hairpin DNAs found to bind strongly to bleomycin, and their methylated counterparts, were used to study the effect of methylation on bleomycin-induced DNA degradation. Under conditions of limited DNA cleavage, there was a significant overall decrease in the cleavage of methylated hairpin DNAs. ...

Members of this family belong to the collagen superfamily [(PUBMED:8240831)]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chains form a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post-translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.. ...

Members of this family belong to the collagen superfamily [(PUBMED:8240831)]. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The sequence is predominantly repeats of the G-X-Y and the polypeptide chains form a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxyproline. Collagens are post-translationally modified by proline hydroxylase to form the hydroxyproline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.. ...

Almost one half of prospective drugs, including new chemical entities are not suitable for clinical use because of their metabolic unstability and for danger of drug interactions. This type of toxicity has been underlying several drug withdrawals in recent years and hence it is needed now to bring with any new compound proposed an information on its metabolism and on its interactions with major drug metabolizing enzyme systems namely with liver microsomal cytochromes P450 (CYP). Then, possibility of drug interactions with other drugs taken by the patient on the basis of drug metabolism may be evaluated to prevent significant losses in time, effort and money in drug development. The analysis of drug metabolism by individual CYPs, the possibility of drug interactions and of induction of individual CYP forms are performed with CYP in vitro systems with the respective substrates, inhibitors and inductors based on the recommendation of the U.S. Food and Drug Administration: ...

Rapid transportation, global trading and improvements in storage have eliminated seasonality from our table, making it possible to get almost any fruit or vegetable at any season. As an example of this, fresh white asparagus produced in Peru is in the stores this winter. Americans favor green asparagus, whereas white (blanched) asparagus seems more popular in Europe. Blanching dates back to at least the 16th century when asparagus forced in cellars became popular with the rich aristocracy. The word blanching is also used in food preservation when vegetables are immersed in boiling water to kill the tissue. But in the gardening sense, blanching is used to describe growing plants in the dark. Asparagus is a labor-intensive crop to produce and blanching requires more of it, so blanched spears cost about 15 percent more than the green form. Blanched plants have a slightly milder taste (some describe it as nuttier) than green asparagus. Chlorophyll forms only in the presence of light so blanched ...

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...

A battery monitor circuit for rechargeable multicell batteries that provides a reliable indication of battery failure independent of temperature, load and age, by continuously comparing the impedance of the cells of the battery against each other. Comparison means are provided responsive to a first voltage at a tapped terminal of the battery that divides the battery cells into two groups, and to a second voltage that represents a fraction of the battery voltage corresponding to the ratio of the number of cells in each group, said comparison means generating an error signal when said first and second voltages change so as to experience a reversal in relative magnitude, which is indicative of cell deterioration.

Bleomycin is a broad-spectrum glycopeptide antitumor antibiotic produced by Streptomyces verticillus. Clinically, the mixture of bleomycin A2 and bleomycin B2 is widely used in combination with other drugs for the treatment of various cancers. As a secondary metabolite, the biosynthesis of bleomycin is precisely controlled by the complex extra-/intracellular regulation mechanisms, it is imperative to investigate the global metabolic and regulatory system involved in bleomycin biosynthesis for increasing bleomycin production. N-acetylglucosamine (GlcNAc), the vital signaling molecule controlling the onset of development and antibiotic synthesis in Streptomyces, was found to increase the yields of bleomycins significantly in chemically defined medium. To mine the gene information relevant to GlcNAc metabolism, the DNA sequences of dasR-dasA-dasBCD-nagB and nagKA in S. verticillus were determined by chromosome walking. From the results of Real time fluorescence quantitative PCR (RT-qPCR) and

One of the key objectives of the study is to assess the feasibility of hydrogen for long-term cost-competitive emissions reduction in Singapore. KBR and Argus will conduct market and technical studies covering potential sources of hydrogen imports to Singapore based on availability, cost, technical feasibility and supply security up to 2050. Hydrogen generation may include fossil fuel-based production methods in the short term and new, low-carbon or green forms of generation in the long term ...

In BioAssay Systems BCG Albumin Assay Kit (DIAG-100), bromcresol green forms a colored complex with albumin where the color (620nm) is proportional to the albumin. New formulation reduces interference by substances. Samples: serum, plasma, urine & biological preparations. Detection range: 0.01- 5 g/dL.

Yale researchers have uncovered a new BET inhibitor-a class of drugs usually used to treat blood cancers-that offers promise against a wider variety of cancers, including solid tumors. The new substance, called NHWD-870, was shown in animal studies to be between three and fifty times more potent against cancer cells than existing BET inhibitors. Additionally, while existing inhibitors produce side effects, including fatigue, nausea, loss of taste, and low platelet counts, NHWD-870 showed lower toxicity (as measured through animals body-weight loss). Lead researcher Qin Yan and his colleagues are now pursuing human clinical trials, testing NHWD-870 on melanoma and small-cell lung cancer patients.. ...

A study released in the July 2016 issue of the American Journal of Roentgenology found that biphenotypic primary liver carcinoma may be misclassified as hepatocellular carcinoma.

Liver carcinoma and normal tissue array, including TNM, clinical stage and pathology grade, 100 cases 200 cores related publications, related pathways and related gentaur products

A Full-Bridge MMC with External DC Link block is used to feed a 1800-HP induction motor. this block is programmed to model five H-bridges in series. Phase-shifting carrier-based PWM technique is used to control the H-bridges.. On the rectifier side, a phase-shifting transformer and a three-phase diode bridge is used to feed each individual DC link. Using phase-shifting transformer allows significantly reducing current harmonics injected into the distribution grid.. In order to cancel harmonics produced by the five six-pulse rectifier units in each phase, voltages applied to the AC side of individual rectifiers must be phase shifted by 60/5 = 12 degrees with each others. These phase shifts are specified in the PhaseShift parameter defined in the model pre-load function (PhaseShift = [12,24,36,48,60]). ...

In article ,2df8d690 at rohmhaas.com,, Kenneth_M_Wiencek at ROHMHAAS.COM (Kenneth M Wiencek) wrote: , Heres a question to ponder... , , What is a biofilm anyway? Is one attached cell a biofilm? 100? , 1000000? A monolayer? Is a 3-D structure a requirement for a , biofilm? .....[edit]....if the characteristics of cells change , immediately upon attachment (a physiological response to being , attached such as increased resistance to antimicrobials), then perhaps , a biofilm could be one attached cell (a biofilm onto itself) It seems to me that combining one attached cell with the exponential growth equation necessarily implies the presence of a large multicell film after not very many generations (or one dead attached cell if the growth rate constant is negative). Single cells are irrelevant except as progenitors for populations. -- R.A.Preston rapr at med.pitt.edu ...

Oncoletter wird über nicht öffentlich zugängliche Werbung für Medizinalpersonen finanziert. Oncoletter finanziert sich zudem mit von Kongressorganisatoren beauftragten Aufnahmen ganzer Kongresse oder Symposien. Weitere Finanzierungsquellen werden bei den jeweiligen Berichten aufgeführt. Die Inhalte der Website von Oncoletter sind strikt redaktionell und widerspiegeln die Meinungen und Ansichten der Autoren. ...

With more than 50 dedicated Aras consultants, and 65+ implementations done, Minerva is one of the largest and most experienced of the Aras partners. Having worked with PLM for over 2 decades Minerva have implemented PLM in almost every industry. Any PLM implementation is performed on the basis of in-depth value chain understanding combined with expert technology services. The result is a combination of business optimization and the establishment of an effective PLM IT platform ...

How can the obstacles to successful PLM implementation be avoided? It is clear that the barriers cannot be eliminated with individual features or superficial changes. Instead, the technology behind such a PLM solution must be fundamentally different than traditional systems.. ...

Do you have facial wrinkles? Glendale Dermatology offers wrinkle fillers in the Queens area. Call our office in Glendale, NY for firm, youthful skin today!