The role of interleukin-8 (IL-8) as a neutrophil chemoattractant in bovine pneumonic pasteurellosis was investigated by characterizing: (1) the expression of IL-8 in the lesions of pneumonic pasteurellosis, (2) the in vitro and in vivo effects of recombinant bovine IL-8 on neutrophil chemotaxis, and (3) the importance of IL-8 as a neutrophil chemoattractant in this disease. The expression of IL-8 in bovine pneumonic pasteurellosis was assessed by Northern analysis, in situ hybridization and enzyme-linked immunosorbent assay. The expression of IL-8 mRNA was elevated dramatically in lesional lung compared to non-lesional lung, viral pneumonia, and normal lung. In situ hybridization revealed intense IL-8 mRNA expression in alveolar macrophages and neutrophils, and milder expression in several other cell types. Bronchoalveolar lavage (BAL) fluid from lesional lung contained 16.06 ± 4.00 ng/ml IL-8, but lower levels were present in non-lesional lung, viral pneumonia, and normal lung (mean ...
Looking for Pasteurellosis? Find out information about Pasteurellosis. A variety of infectious diseases caused by the coccobacilli Pasteurella multocida and P. haemolytica ; the term also applies to diseases caused by any... Explanation of Pasteurellosis
Pasteurellosis in Cattle Also known as: Transit Fever, Shipping Fever Pneumonic pasteurellosis is most commonly seen in recently weaned, single-suckled beef calves after housing or transport to a new herd/premises.
Pasteurellosis is an infectious disease caused byPasteurella multocida, a Gram-negative coccobacillus .The disease is characterized by congestion and haemorrhage of young skin. The bacteria may enter blood leading to septicemia.
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These bacteria are present in the respiratory tract of healthy animals, where they behave as opportunists in case of immunodeficiency. Clinical symptoms caused by P. multocida include enzootic pneumonia and to a lesser degree fibrinous pneumonia (shipping fever). Both are considered multifactorial syndromes, in which infectious and non-infectious factors are involved.. ...
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