In the review, the role of integrin receptors as well as of some of their ligands of the extracellular matrix in cases of parotid neoplasms is discussed, in
Discussion: Parotid gland neoplasms are quite rare in the pediatric population but when such a lesion is encountered, a higher percentage (40-50%) will be malignant when compared to the adult population (25-35%); therefore, parotid neoplasms in children must be approached with suspicion (1). The mean age at which malignant parotid gland neoplasms occur in the pediatric population is 13.2 years (2). Acinic cell carcinoma (ACC) accounts for an appreciable number of pediatric parotid malignancies; in fact, it is the second most common malignant parotid tumor in this population followed by mucoepidermoid carcinoma (3). Nasse first described the lesion in a 1892 publication in which four cases of parotid adenomas were described (4). Due to the similarity of the tumor cells to normal salivary tissue, the lesions were initially regarded as benign. The benignity of the lesion was questioned in 1953 when Buxton et al. reported three cases of ACC with verified distant metastases (5). Therefore, the lesion ...
Pleomorphic adenoma is notorious of its propensity to local recurrence due to the microscopic extracapsular extension of the tumor. Superficial parotidectomy (SP) is the standard treatment. Extracapsular dissection (ED) has been proposed to minimize the risk of facial nerve palsy. However, the oncologic safety of ED is controversial in the literature. We propose quadrant parotidectomy (QP) which is less radical than SP and less conservative than ED. QP entails dissection overlying one primary division of the facial nerve leaving the other division undisturbed while the resection safety margin is still generous.. Surgery for pleomorphic adenoma is a compromise between radicality and facial nerve morbidity. Risk of local recurrence is imprecisely described in the literature and is universally regarded as infrequent and remote. Many studies did not report recurrent cases. Thus, Facial nerve injury is the main concern of parotid surgeons and is considered the primary end point of this study. ...
A 32 year old woman presented with a large swelling in the left parotid area. Past history revealed that the patient had undergone enucleation of a left parotid mass at 9 years of age that showed "calcular atrophy with sialadenitis", and superficial parotidectomy of a recurrent mass at 15 years of age that was considered "pleomorphic adenoma". A magnetic resonance imaging showed an 11.8 x 6 cm mass in the left parotid area extending into the infratemporal fossa and the parapharyngeal space. The mass was removed by total parotidectomy. ...
A parotidectomy is the surgical excision (removal) of the parotid gland, the major and largest of the salivary glands. The procedure is most typically performed due to neoplasms (tumors), which are growths of rapidly and abnormally dividing cells. Neoplasms can be benign (non-cancerous) or malignant (cancerous). The majority of parotid gland tumors are benign, however 20% of parotid tumors are found to be malignant. A parotidectomy is performed mostly by the oral and maxillofacial surgeons and otolaryngologist. There are two parotid glands in the human body. Each parotid gland is located high in the neck just below the ears. A salivary duct by which saliva is secreted (produced and released), runs through the inside of each cheek from each gland. Furthermore, the extratemporal (outside temporal bone) facial nerve and its subsidiaries run through the parotid gland and innervate (supply nerves to) the face. This nerve articulates the muscles for facial expression as well as more specific muscles ...
TY - JOUR. T1 - A study on seventy-eight cases of parotid tumor. AU - Suzuki, Takahiro. AU - Ikushima, Hiroyuki. AU - Kakuta, Risako. AU - Noguchi, Naoya. AU - Ogura, Masaki. AU - Ogawa, Takenori. AU - Katori, Yukio. AU - Shoji, Fumi. AU - Ohta, Nobuo. PY - 2017. Y1 - 2017. N2 - We reviewed 78 cases of parotid gland tumors treated at our hospital over the past 2 years and 5 months. Benign tumors were observed in 65 patients (36 males and 29 females), and malignant tumors were observed in 13 patients (4 males and 9 females). The average patient age was 50 years old for the cases with benign tumors and 65 years old for the cases with malignant tumors. The most common benign tumor was pleomorphic adenoma, followed by Warthins tumor. The most common malignant tumor was mucoepidermoid carcinoma. The sensitivity/specificity/accuracy of preoperative fine-needle aspiration cytology (FNA) were 27.3%, 96.8%, and 86.5%, respectively, while those of MRI were 84.6%, 86.2%, and 85.9% when an unsharp margin ...
Objective:The Purpose of this study was to analyze the clinical presentation, histopathology and complications following parotid surgery. Methods: We retrospectively reviewed the charts of 112 Patients who underwent parotidectomy from January 2000 to February 2010. Data including age, sex, clinical signs and symptoms, histology and complication were collected from medical records. Results: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors. The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%). Analysis of the correlation between fine-needle aspiration cytology and final histology revealed that fine-needle aspiration sensitivity, specificity and accuracy to 86.6%, 97.6% and 94.6% respectively. The most common complication following parotidectomy was transient facial nerve palsy (18.7%). Conclusions: Superficial parotidectomy is associated with a decrease incidence of transient facial nerve dysfunction
Objective: The purpose of this study was to analyze the clinical presentation, histopathology and complications following parotid surgery. Methods: We retrospectively reviewed the charts of 112 patients who underwent parotidectomy from January 2000 to February 2010. Data including age, sex, clinical signs and symptoms, histology and complication were collected from medical records. Results: Of the total, 82 (74%) had benign lesions, 30 (36%) had malignant tumors. The most common benign tumor was pleomorphic adenoma (57%), and the most common malignant tumor was mucoepidermoid carcinoma (16%). Analysis of the correlation between fine-needle aspiration cytology and final histology revealed that fine-needle aspiration sensitivity, specificity and accuracy to 86.6%, 97.56% and 94.64% respectively. The most common complication following parotidectomy was transient facial nerve palsy (18.7%). Conclusion: Superficial parotidectomy is associated with a decrease incidence of transient facial nerve dysfunction
TY - JOUR. T1 - Body mass index and parotidectomy outcomes. AU - Ziegler, Andrea. AU - Teng, Stephanie Erh Shuen. AU - Thorpe, Eric. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Multiple specialties have demonstrated increased risk of certain postoperative complications in patients with an increased body mass index (BMI). The goal of this study was to understand the outcomes of patients undergoing parotidectomy with an increased BMI and to identify any other patient risk factors for postoperative complications. This study was a retrospective chart review of 432 patients. Patient variables collected included BMI, age, gender, history of diabetes mellitus, type of parotidectomy, and pathology. Outcomes reviewed included facial nerve weakness, hematoma or seroma formation, and wound infection. The results showed that BMI had no statistically significant effect on complications. However, patients undergoing a total parotidectomy, malignant pathology, and patients with a history of diabetes mellitus had ...
Background Parotidectomy is a common treatment option for parotid neoplasms and the complications associated with this procedure can cause significant morbidity. Reconstruction following parotidectomy...
The HS utilizes ultrasonic vibration to denature proteins, forming a coagulum for hemostasis while also limiting thermal injury to surrounding tissue. Since the introduction of the HS, it has been shown to be effective in decreasing operative blood loss across a variety of procedures, from total colectomy to hepatectomy [13, 14]. In the otolaryngology literature, the HS has been shown to decrease blood loss and operative times for thyroidectomies, parotidectomies, and neck dissections [10, 15, 16].. This study is the largest to date comparing the Harmonic Scalpel to cold steel in parotidectomy. Our results corroborate prior parotidectomy studies on the HS, showing both a reduction in blood loss and decrease in operating room time when compared to SB (see Table 1). The benefit of using the HS in total parotidectomy procedures is even more compelling as the differences in blood loss and operative time between groups was greater. While the difference in blood loss between groups in this study was ...
RESULTS: The useful items were , 5.1 microm in mean of epithelial nuclear short diameter; mild atypia on definitive diagnosis; stromal cell cluster combining smooth margin surrounding the epithelial cell cluster or containing the epithelial cell cluster; epithelial clusters surrounded by or adhered to a thick, hyalinized smooth margin without stromal cluster; and closely fastened, tight clusters with denser cytoplasm than ADCC, but an indistinct border, with oval nuclei and no hyaline cells ...
A unique relationship exists between the facial nerve and the parotid gland. The facial nerve travels through the gland, effectively separating it into a deep and superficial lobe. Knowledge of this intimate relationship is important for your surgeon as a potential complication of a parotidectomy is facial nerve paralysis, resulting in partial or complete facial muscle paralysis. However, with proper technique and surgical planning, this outcome is largely avoidable.. If you are interested in learning more about the surgical treatment of salivary gland tumors, please contact us for further information ...
Parotid tumors are an abnormal growth of cells formed in the parotid glands causing partial or permanent paralysis of the facial nerves.
The parotid is a gland near the ear. It helps produce and control the release of saliva. If a tumor forms in the parotid gland, it can press on the facial nerve, causing discomfort and pain. Part or all of the face may be weak or paralyzed. To treat a parotid tumor, part or all of the gland is removed. This surgery is called parotidectomy. This sheet explains the surgery and what to expect.
Free Online Library: Sarcoidosis presenting as a solitary parotid mass: an uncommon but real diagnostic challenge.(LETTERS TO THE EDITOR, Letter to the editor) by Ear, Nose and Throat Journal; Health, general Autoantibodies
Autophagy is frequently activated in radioresistant cancer cells where it provides a cell survival strategy. The mTOR inhibitor rapamycin activates autophagy but paradoxically it also enhances radiosensitivity. In this study, we investigated the mechanisms of these opposing actions in radiation-resistant glioma or parotid carcinoma cells. Radiation treatment transiently enhanced autophagic flux for a period of 72 hours in these cells and treatment with rapamycin or the mTOR inhibitor PP242 potentiated this effect. However, these treatments also increased heterochromatin formation, irreversible growth arrest, and premature senescence, as defined by expression of senescence-associated β-galactosidase activity. This augmentation in radiosensitivity seemed to result from a restoration in the activity of the tumor suppressor RB and a suppression of RB-mediated E2F target genes. In tumor xenografts, we showed that administering rapamycin delayed tumor regrowth after irradiation and increased ...
for whatever reason you need to do a superficial parotidectomy (removing the superficial lob of the parotid gland, the main salivary gland) the disection is fine and finicky. the facial nerve, the nerve that supplies the muscles of the face, runs right through the gland, breaking up into its tiny branches right in the middle. the operation requires the surgeon to find the root of the nerve where it comes out of the skull and to painstakingly follow it through the gland, identifying each of its branches as he goes. nerve injury is a real consideration. at best this may cause paralysis of a certain area of the face, depending on what branch is injured. but at worst this can cause total paralysis of one side of the whole face. the patient would have a drooping mouth on the one side and an eye that just wont close. this is a disaster as any attempt to smile would result in a weird distorted facial expression. but even worse, the eye would dry out and finally be damaged too ...
for whatever reason you need to do a superficial parotidectomy (removing the superficial lob of the parotid gland, the main salivary gland) the disection is fine and finicky. the facial nerve, the nerve that supplies the muscles of the face, runs right through the gland, breaking up into its tiny branches right in the middle. the operation requires the surgeon to find the root of the nerve where it comes out of the skull and to painstakingly follow it through the gland, identifying each of its branches as he goes. nerve injury is a real consideration. at best this may cause paralysis of a certain area of the face, depending on what branch is injured. but at worst this can cause total paralysis of one side of the whole face. the patient would have a drooping mouth on the one side and an eye that just wont close. this is a disaster as any attempt to smile would result in a weird distorted facial expression. but even worse, the eye would dry out and finally be damaged too ...
Tumours of the nasal cavity, sinuses, and nasopharynx 340Tumours of the oral cavity, oropharynx, and hypopharynx 344Head and neck cancer reconstruction 351Salivary gland tumours 354Superficial parotidectomy 357Neck dissection 359• 0.2-0.8% of all cancers; 3% of head and neck malignancies....
Dr.Meenesh Juvekar. M.S (ENT), D.N.B, D.O.R.L, M.N.A.M.S (Ear-Nose-Throat & Head Neck surgeon) Call 91+022-25271150 for appointment
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Sagiv, D, Witt, RL, Glikson, E, Mansour, J, Shalmon, B, Yakirevitch, A, Wolf, M, Alon, EE, Slonimsky, G & Talmi, YP 2017, Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis, European Archives of Oto-Rhino-Laryngology, vol. 274, no. 4, pp. 1993-1996. https://doi.org/10.1007/s00405-016-4436-0 ...
Extracapsular dissection can be an effective and low-risk method for removing benign, supercial parotid tumors that are less than 4 cm. ...
To our knowledge, few reports on the imaging of oncocytic neoplasms of the salivary glands have been published, owing to the rarity of the condition. Sakai et al1 reported an oncocytoma in the deep lobe of the parotid gland that was well-defined and solid on CT. It demonstrated decreased signal intensity on both T1- and T2-weighted MR images, attributed to the high cellularity and low free water content. According to the authors, Warthin tumor, which is a common benign parotid gland tumor in patients older than 60 years, can be differentiated from oncocytoma by its MR imaging appearance. Warthin tumors conversely demonstrate decreased signal intensity on T1-weighted images and increased signal intensity on T2-weighted images.1 Both Warthin tumors and oncocytomas show intense uptake of the nuclide on technetium-Tc99m pertechnetate radionuclide scans of the salivary glands.2. The histomorphologic findings of oncocytes include an enlarged polygonal shape with granular intensely acidophilic ...
Ultrasound images demonstrate a well demarcated, hypoechoic mass or a solid mass with multiple anechoic internal areas. On CT, Warthin tumors are homogeneous, enhancing soft tissue densities that contain no calcification. If calcifications are present in a benign appearing parotid mass, the diagnosis of pleomorphic adenoma should be favored. Warthin tumors are traditionally located in the posterior aspect of the tail of the parotid gland but the tumors have been known to arise from periparotid lymph nodes. Cyst formation is common and the larger the tumor the greater the chance for cystic change. On MR imaging, the tumors have low T1 and high T2 signal (similar to pleomorphic adenomas). Warthin tumors are rich in mitochondrium and therefore will accumulate Tc-99m pertechnetate on salivary scintigraphy. Unfortunately, oncocytomas and the extremely rare oncocytic carcinoma both accumulate pertechnetate as well. Imaging findings that suggest a malignant parotid mass include; irregular margins, ...
Warthins tumor primarily affects older individuals (age 60-70 years). There is a slight male predilection according to recent studies. The tumor is slow growing, painless, and usually appears in the tail of the parotid gland near the angle of the mandible. In 5-14% of cases, Warthins tumor is bilateral, but the two masses usually are at different times. Warthins tumor is highly unlikely to become malignant. ...
Parotid Gland Acinic Cell Carcinoma (Acinic Cell Carcinoma of Parotid): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Cell phone use has been linked to tumors once again - this time by an Israeli study that found that frequent cell phone users were more likely to develop parotid gland tumors than the population as a whole. The Israeli study is just the latest research to find a connection between cell phone use and a serious <"http://www.yourlawyer.com/practice_areas/diseases">disease. The cell phone tumor study, which is being published today in the "American Journal of Epidemiology", is sure to catch the attention of anyone who spends a great deal of time glued to their cell phone.. The parotid gland is the largest of the salivary glands. The Israeli study looked at 402 adults with benign parotid gland tumors and 58 others who had malignant tumors of the parotid gland diagnosed in Israel from 2001-2003. According to the researchers, people who spent more than 22 hours a month on their cell phones where 50-percent more likely to develop cancer of the parotid gland than those who used the phones less often. The ...
Dr. Larian is specialist performing parotidectomy, or parotid surgery, in Los Angeles. He helps people suffering from parotid tumors, parotitis, salivary gland tumors & more.
MRI and PET images demonstrate a right parotid pleomorphic adenoma. Pleomorphic adenomas are the most common salivary gland tumours. This case was donated to Radiopaedia.org by Radswiki.net
C.C. Mirestean, Roxana Irina Iancu, C. Buzea, D.T. Iancu. Abstract. Cystic adenoid carcinoma is a rare tumor accounting for less than 1% of all malignant tumors of the head and neck. The presence of another synchronous cancer in the head and neck region is so much a rare case. We present the case of a patient diagnosed with locally advanced neoplasm of the right parotid gland with invasion in the mandible for which surgical treatment was performed. During the post-surgical hospitalization, the patient presented respiratory dysfunction caused by a bulky tumor of the thyroid gland, for which the pathology proved a micro papillary carcinoma. Evidence of a resection margin in contact with tumor of the parotid gland tumor made it necessary a multidisciplinary approach including adjuvant radiotherapy. The patient was also consulted in a nuclear medicine department for metabolic radiation therapy for thyroid cancer. Radiation therapy is part of the adjuvant treatment of head and neck cancers, the risk ...
Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. Int J Oral Maxillofac Surg 2010;39: 235-42. Chapnik JS. The controversy of Warthins tumor. Laryngoscope 1983; 93: 695-716. Naujoks C, Sproll C, Singh DD, Heikaus S, Depprich R, Kübler NR et al. Bilateral multifocal Warthins tumors in upper neck lymph nodes. Report of a case and brief review of the literature. Head Face Med. 2012; 3: 8-11. Maiorano E, Lo Muzio L, Favia G, Piattelli A. Warthins tumour: a study of 78 cases with emphasis on bilaterality, multifocality and association with other malignancies. Oral Oncol. 2002; 38: 35-40. Teymoortash A, Krasnewicz Y, Werner JA. Clinical features of cystadenolymphoma (Warthins tumor) of the parotid gland: a retrospective comparative study of 96 cases. Oral Oncol 2006; 42: 569-73. Singer MI, Applebaum EL, Loy KD. Heterotopic salivary tissue in the neck. Laryngoscope 1979; 89: ...
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Objectives : To determine whether outpatient parotidectomy can be performed safely with high patient satisfaction and to compare the cost of outpatient and inpatient parotidectomy. Design : A retrospective review of hospital and office charts of patients admitted for elective outpatient and inpatient parotidectomy from 1992 to 1994. Setting : A...
One case of intraductal carcinoma of the parotid gland in a 67-year-old male patient is here introduced. The patient, who had a one-year history of a parotid mass, had undergone ultrasound and MRI examination that disclosed a 13x4x3 mm well delimited nodular mass of the accessory lobe of his left parotid gland. Ultrasound-guided Fine Needle Aspiration (FNA) had been performed by the clinician. The obtained smears showed widespread cellular necrosis in which cellular clusters with moderate and focally severe atypias displayed papillary and cribriform architecture and were admixed with sheets of epithelial cells with less striking nuclear atypias, squamous, or apocrine metaplasia ...
Pleomorphic adenoma is the most common salivary gland tumor on the head and neck region [1]. Metastasizing pleomorphic adenoma is a rarely detected form of clinic antity [2,3]. According to the World…
A 75-year-old man presented with a left ear lobule melanoma and was found, on examination, to have a concurrent right parotid mass and bilateral cervical lymphadenopathy. A CT scan of the neck confirmed a 2-cm right superficial parotid mass containing both solid and cystic components without any pathognomonic characteristics, as well as bilateral cervical lymphadenopathy with multiple 2- to 3-cm lymph nodes. FNA biopsy of the parotid mass was consistent with carcinoma, whereas FNA samples from the cervical lymph nodes were non-diagnostic.. ...
Enlarged left parotid gland with with inflammatory changes harbouring an intraglandular collection with marginal enhancement proved to abscess formation.
Luminita Daguci(1), Cristiana Simionescu(2), C. Daguci(1), Marilena Bataiosu(3), L. P. Dragomir(1) (1) Restorative Dentistry Department , UMF Craiova (2) Pathology Department, UMF Craiova (3) Odontology Department, UMF Craiova Abstract The study includes 16 cases of Warthin s tumor in a period of 4 years (2004-2008). The tumors were diagnosed at patients of VII decade, most of them smoker. The studies of Warthin s tumor macroscopic morphological parameters
A parotidectomy is a surgical procedure that involves the removal of the parotid gland, which is the largest salivary gland. This is a typical treatment for neoplasms (tumors) that are found to affect the parotid gland.
Skin: BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/ ...
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Learn more about Parotidectomy at Memorial Hospital DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
Adenoid cystic carcinoma: Tends to infiltrate perineural spaces and causes pain. (This well have to remember, unless you submit us a mnemonic! =D ) ...
Dr. Charles Wallace of Beauty By Design offers his Dallas patients the latest techniques in facial surgery, like facelift, also called rhytidectomy.
The parotid glands are saliva-producing glands located just in front of the ears. They are the largest of the salivary glands, and...
Parotid glands of experimental animals fed a liquid diet are reported to show atrophy (Hall and Schneyer 1964; Wilborn and Schneyer 1970; Hand and Ho 1981; Scott et al. 1990; Scott and Gunn 1991). To clarify whether apoptosis and proliferation of aci
A procedure is described for the preparation of basolateral membrane vesicles from the acinar cells of the sheep parotid gland. The ouabain-sensitive K(+)-activated phosphatase activity was enriched 30-fold over the tissue homogenate; 45% of this activity was recovered in the final membrane fraction. The presence of membranes from other organelles was negligible. Evidence is presented for the location of Na(+)-dependent symporters for phosphate and D-glucose on the basolateral membrane. ...