A previously fit and well 32 year old man was admitted to the neurology ward in November 1998 with a 24 hour history of rapidly progressive leg weakness such that he was unable to stand. He felt tingling in his hands and lower legs, but no loss of sensation. Two weeks earlier he had noticed intermittent weakness in both legs. He reported no other neurological or constitutional symptoms. Twelve weeks earlier he had returned from a holiday in California.. His past medical history was unremarkable except for bronchial asthma controlled by salbutamol and beclomethasone inhalers. On further questioning, he admitted to unusually more colds than normal as well as mild fatigue and tiredness of six months duration.. On examination, he was tanned with palmar crease and buccal pigmentation. His pulse was regular at 80 beats/min, blood pressure was 130/60 mm Hg (unable to stand to check postural drop), and his temperature was normal. The remaining general physical examination was normal. Higher mental ...
Background: Intrathecal bleeding can be subdural, subarachnoid or intramedullary depending on its location. Intrathecal bleeding within the lumbar spine is seldom reporte..
Todays case is a 10-year-old male neutered Boxer with a six-week history of progressive cerebral signs. He is growling at the owner, circling, and pacing to the left. He has incontinence and is incoordinated. He has had two seizure episodes. What is your diagnosis? … [Read more...] ...
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Introduction: The rate of spinal cord infarction associated with repair of an aortic aneurysm or dissection is uncertain.. Methods: We identified all adult patients discharged from nonfederal acute care hospitals in California, New York, and Florida who underwent surgical or endovascular repair of a thoracic or abdominal aortic aneurysm or dissection between 2005 and 2013. Our outcome was a spinal cord infarction (ICD9-CM codes: 336.1 or 344.1-5) occurring during the index hospitalization for aortic repair. Patients with a spinal cord infarction prior to the hospitalization for aortic repair were excluded. Descriptive statistics with exact confidence intervals (CIs) were used to report crude rates of spinal cord infarction in patients with repair of ruptured aortic aneurysm or dissection and in patients with repair of unruptured aneurysm. In a secondary analysis, we evaluated the rate of spinal cord infarction in these groups by treatment approach - surgical versus endovascular.. Results: We ...
• Han JJ, Massagli TL and Jaffe KM (2004). Fibrocartilaginous embolism--an uncommon cause of spinal cord infarction: a case report and review of the literature. Arch Phys Med Rehabil. 85: 153-7. Childrens Hospital and Regional Medical Center and Department of Rehabilitation Medicine, University of Washington, Seattle, USA. [email protected] Fibrocartilaginous embolism is a rare cause of spinal cord infarction. It is postulated that an acute vertical disk herniation of the nucleus
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ADEM is a rare autoimmune disease that causes lesions in the brain and spinal cord. Disease is usually triggered by a previous infection or vaccination, although why this occurs is not well understood. For example, one in 1,000 people infected with measles goes on to develop ADEM. Rates of disease have decreased in developed countries, due to reduced rates of infection.. Immune cells normally protect our body against disease, by killing invading viruses and bacteria. In ADEM, these immune cells attack our nerves within the brain and spinal cord and cause damage. Damage destroys the insulating coating on our nerve cells, called myelin, and interferes with signalling in the nervous system.. Early symptoms include fever, low energy, headache nausea and vomiting. Within several days, symptoms escalate and can range from low energy to coma, with weakness along one side of the body or in the legs (hemiparesis/paraparesis). Symptoms can also include loss of control of body movements (ataxia) and other ...
... MUHAMED IBRAHEEM JALAL AL-MASRY 26 YEARS SEVERE PARAPARESIS DUE TO EXOPHYTIC LOW-GRADE ASTROCYTOMA OF THE SPINAL CORD WITH ANTERIOR EXTRAMEDULLARY CYST.
TY - JOUR. T1 - Spontaneous spinal epidural hematoma in children. AU - Patel, Hema. AU - Boaz, Joel C.. AU - Phillips, John P.. AU - Garg, Bhuwan P.. PY - 1998/10/1. Y1 - 1998/10/1. N2 - Spontaneous spinal epidural hematoma is rare in children. It is usually confined to the dorsal epidural space. Ventral spontaneous spinal epidural hematoma (SSEH) is rarer, with only two previous reports. The authors present three children, two with dorsal and one with ventral spinal epidural hematoma, and review the literature. No etiology of the hematoma was found in the authors patients and there was no history of trauma. A review of 24 patients of children younger than 18 years of age reported in the literature and the authors three patients revealed that the cervicothoracic region was the most common site of SSEH, the mode of onset was frequently subacute, and there was no male preponderance as has been reported in adults. We found that the initial symptoms were often nonspecific, leading to a delay in ...
The posterior spinal cord contains longer perforating arteries that might be more susceptible to the effects of CADASIL vasculopathy. This explains the clinical (predominantly dorsal column involvement and motor deficit) and imaging features compared with those in the more common anterior spinal cord infarction (predominantly spinothalamic tract involvement and motor deficit). The stepwise progression could be explained by sequential involvement of perforating spinal cord arteries. Her clinical improvement is likely attributable to the combination of corticosteroid-responsive peri-ischaemic inflammatory changes and natural recovery.. Spinal cord involvement in CADASIL is well recognised but rare. In a UK cohort of 200 patients, there were no cases of spinal cord infarction.1 An anterior spinal cord infarct occurred in an Irish patient with probable CADASIL who had a history of severe migrainous headaches.7 A cervical spinal cord MRI study showed no abnormalities in 25 symptomatic CADASIL ...
TY - JOUR. T1 - Spontaneous spinal epidural hematomas of cervical spine. T2 - report of 4 cases and literature review. AU - Hsieh, Cheng Ta. AU - Chang, Cheng Fu. AU - Lin, En Yuan. AU - Tsai, Tung Han. AU - Chiang, Yung Hsiao. AU - Ju, Da Tong. PY - 2006/10. Y1 - 2006/10. UR - http://www.scopus.com/inward/record.url?scp=33748576621&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33748576621&partnerID=8YFLogxK. U2 - 10.1016/j.ajem.2006.01.025. DO - 10.1016/j.ajem.2006.01.025. M3 - Article. VL - 24. SP - 736. EP - 740. JO - American Journal of Emergency Medicine. JF - American Journal of Emergency Medicine. SN - 0735-6757. IS - 6. ER - ...
Abstract The most common neurological impairments related to schistosomiasis involve the lower portions of the medulla and the cauda equina. A 22-year-old woman, with no history, signs, or symptoms of hepatointestinal schistosomiasis, presented with lumbar pain associated with acute paresthesia and paresis of the right lower limb. Spinal schistosomiasis was suspected based on the disease progressi...
Non-obesity related Spinal epidural Lipomatosis: I was diagnosised last week. Im 30 lbs max overweight, 52 yr old woman. Im having symptoms of both legs numbness, tingling, heaviness, weakness, MRI s...
Abstract : We report the case of a patient admitted to our intensive care unit in the course of a septic shock, secondary to cholangitis. After rapid hemodynamic stabilization, antibiotherapy, and end...
Results Twelve (eight male) patients were identified. Median (range) age was 9.5 (2-16) years.. The considered clinico-radiological diagnosis pre-biopsy included: non-neoplastic space occupying lesion (n = 5), central nervous system (CNS) vasculitis (n = 3), encephalitis (n = 2), neurosarcoidosis (n = 1) and pachymenigitis (n = 1). Presenting features included: signs of raised intracranial pressure (n = 4); cerebellar signs [(n = 3, one with growth failure and diabetes insipidus and another with a progressive paraparesis]; encephalitis with seizures and a movement disorder (n = 1); steroid dependent encephalitis (n = 1); transient ischaemic attacks (n = 2) and neurological regression with a movement disorder and epilepsy (n = 1).. Twelve biopsies were from the identified lesion and two were from non-lesional from the frontal lobe (suspected CNS vasculitis). Two children (suspected neurosarcoidosis and pachymeningitis) had repeat lesional biopsies before immunosuppressant treatment was ...
A general term referring to a mild to moderate degree of muscular weakness, occasionally used as a synonym for PARALYSIS (severe or complete loss of motor function). In the older literature, paresis often referred specifically to paretic neurosyphilis (see NEUROSYPHILIS). General paresis and general paralysis may still carry that connotation. Bilateral lower extremity paresis is referred to as PARAPARESIS ...
Shrimpton AE, Schelper RL, Linke RP, Hardy J, Crook R, Dickson DW, Ishizawa T, Davis RL. A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis ...
However, sweating unrelated use anhydrous ammonia industrial materials, pharmaceuticals, and production ... proximal portion stroke, and paraparesis.
Tropical Spastic Paraparesis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
He needed to be hand fed by the owner because of painful mouth," I said. "No dental for the past 10 or more years.The toxins from the mouth bacteria could have passed via the blood to the brain and body causing lethargy and difficulty to stand up for the past 2 weeks. But overnight, he just could not stand on his hind limbs. He had paraparesis or paraplegia ...
When i wanna play a smaller neck, i just bust out my first electric guitar i got when i was a youngster and pluck round! This are the official uk top singles charts for this week of january , Weakness in the arms or legs paraparesis sensory symptoms paresthesias such as numbness, tingling, burning, tickling, or prickling in the legs, feet or mature online dating sites completely free toes. Stiltsville is a collection of buildings on pilings on several sand flats at looking for old seniors in florida the northern end of the safety valve. They were created by bob thomas - an old friend of bears who was an accomplished artist and musician in his own right. Top trending stain colors for outdoor spaces the idea that only brown stains should be used to accentuate your patio or deck is a thing of the past green, grey, and blue among other vibrant colors have become popular wood stain colors, and even clear sealants can provide a unique and beautiful way to add additional pizazz to your home while ...
GENERICS & PATENT LIFE CYCLE MANAGEMENT Strategies in the Pharmaceutical Industry 2004 30th November and 1st December 2004 Workshop - 29th November 2004 Hilton Kensington, London ++FULL AGENDA BELOW. mailto:Joe.stone at visiongain.com for your PDF copy of the brochure++ Visiongain Conferences are please to announce their next conference within the pharmaceutical sector; Generics & Patent Life Cycle Management 2004. This conference shall focus on the strategies adopted by generic and branded pharmas to battle against each other in the effect of generic erosions, and discuss the future of biologics facing patent expirations. KEY THEMES **Current Legislative Hurdles & Movements Faced by the Industry **How to Maximise Profit by Effective Patent Life Cycle Management **Post-Election Update - Effect of Political Interference ** Evergreening Strategies to Compete with Generics **Examine Novel Methods to Protect you IPs **Strategies to Improve your Sales & Marketing **Advice on Becoming a Generic ...
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We present a case of spinal epidural hematoma after Lumbar catheter insertion in a patient who underwent TEVAR for an aneurysm of the descending aorta. Spinal epidural he..
Courtesy of Gods Emerald An Excerpt from My Memoir - Captive in the Mirror Shanes Revenge - August 1992 (Shane, the leader of the ruthless gang of mob-controlled sex traffickers, held me captive in New York City for three years) The sundrenched Sunday morning of August 30, 1992, foretold a beautiful day, and Carlito and I went…
Dendritic cells (DC), important antigen-presenting cells for recruiting T cells into immune responses, are susceptible to infection with HIV-1 and this can cause either stimulatory or suppressive effects on T cells. We examined another human retrovirus, HTLV-1, to determine whether DC were infected …
Objectives: Influence of neurological status on the mortality rate of paraparetic/paralysed cats presenting after entrapment in a bottom-hung window was evaluated. It was hypothesised that (1) loss of deep pain sensation at admission would not be a negative prognostic factor for regaining motor function and that (2) mortality rate would be influenced by the severity of neurological grade upon admission. Methods: Clinical and pathological data of affected cats that presented at our institution between 2001 and 2012 for this specific trauma were collected retrospectively: breed, age, sex, last contact with owner (,3 hours and ,3 hours), whether the cat was suffering from monoparesis or paraparesis/paraplegia, duration of hospitalisation, rectal temperature, surface temperature of the skin of the hindlimbs, femoral pulse and tone of the pelvic musculature ...
Disease: (OMIM: 238970 603861) Defects in SLC25A15 are the cause of hyperornithinemia- hyperammonemia-homocitrullinuria syndrome (HHH syndrome) [MIM:238970]. It is an autosomal recessive disorder resulting in various neurologic symptoms, including mental retardation, spastic paraparesis with pyramidal signs, cerebellar ataxia, and episodic disturbance of consciousness or coma caused by hyperammonemia. It causes a functional impairment of the urea cycle ...
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HISTORY. A 12 year-old, male mixed-breed dog presented with a 1-month history of chronic paraparesis. Physical examination was unremarkable. Neurologic examination showed non-ambulatory paraparesis, CP deficits in both pelvic limbs, worse on the left, and normal spinal reflexes. Pain was not detected on paraspinal palpation. Lesion localization was T3-L3. Main differential diagnoses included neoplasia, degenerative disease and infectious/inflammatory conditions. CBC and serum biochemical profile showed abnormalities consistent with chronic steroid administration. Thoracic radiographs and abdominal ultrasound were unremarkable. Plain spinal radiographs and myelography were performed under general anesthesia. The LL myelographic views showed thinning of the dorsal contrast column over T2-T4. On the VD views a marked deviation of the spinal cord to the right was observed at T3-T4. CT confirmed the presence of an extradural, soft tissue mass at T3-T4, on the left side of the vertebral canal, ...
It should be noted that the distribution of vascular syndromes and the distribution of etiologies in this study differ from those in several other studies because of the inclusion/exclusion criteria. For example, by excluding cases associated with surgery (eg, aortic surgery) or trauma, there are fewer cases associated with hypotension and a larger proportion with causes that were not clearly identified. Nevertheless, Masson and colleagues also reported that a definite cause of spinal cord infarction was identified in less than half of patients (Masson et al 2004).. The authors also provided a further analysis of potential etiologic factors. This analysis must be considered exploratory for a number of reasons: (1) data were obtained retrospectively and are susceptible to various forms of bias (recall, ascertainment, etc.); (2) sample sizes within each group were quite small; (3) comparisons were not specified a priori and all comparisons made were not elaborated; (4) given the nature of the ...
In 1959 Cook (1) described a clinical syndrome of the occlusion of the abdominal aorta which was dominated by neurological abnormalities. He found four similar cases (2, 3) described under different names and explained differently in respect to their etiology and mechanism. On the basis of his observation of his own two cases and those from the literature, Cook gave the following clinical picture of the syndrome: rapid onset of varying degrees of paraparesis; neurological signs reaching the seventh dorsal segment; areflexia or hyporeflexia of the lower extremities, impaired proprioceptive sensibility; presence of bilateral Babinskis signs; incontinence of the feces ...
We report a novel missense mutation in the ABCD1 gene in a 47-year-old French-Canadian female with spastic paraparesis and no confirmed family history of X-linked adrenoleukodystrophy. The mutation is located on exon 1 and causes the amino acid substitution of a valine for an alanine in a region of the protein highly conserved between mouse and man ...
Uttner I, Kirchheiner J, Tumani H, Mottaghy FM, Lebedeva E, Ozer E, Ludolph AC, Huber R, von Arnim CA. A novel presenilin1 mutation (Q223R) associated with early onset Alzheimers disease, dysarthria and spastic paraparesis and decreased Abeta levels in CSF ...
TY - JOUR. T1 - Radionuclide demonstration of spinal dural leaks.. AU - Liebeskind, A. L.. AU - Herz, D. A.. AU - Rosenthal, A. D.. AU - Freeman, Leonard M.. PY - 1973/6. Y1 - 1973/6. UR - http://www.scopus.com/inward/record.url?scp=0015634378&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015634378&partnerID=8YFLogxK. M3 - Article. C2 - 4701833. AN - SCOPUS:0015634378. VL - 14. SP - 356. EP - 358. JO - Journal of Nuclear Medicine. JF - Journal of Nuclear Medicine. SN - 0161-5505. IS - 6. ER - ...
Intramedullary spinal cord tumors, like the one depicted in the image below, refer to a subgroup of intradural spinal tumors that arise from cells within the spinal cord, as opposed to adjacent structures such as the nerve roots or meninges. They are much less common than brain tumors and are thought to account for only 2-4% of all intrinsic ...
Rosenthal, MA, Ashley, David M., Drummond, K, Dally, M, Murphy, M, Cher, L, Thursfield, V and Giles, GG 2008, Intramedullary spinal cord tumors: patterns of care in Victoria from 1998-2000, Asia-Pacific journal of clinical oncology, vol. 4, no. 2, pp. 77-80, doi: 10.1111/j.1743-7563.2008.00151.x. ...
TY - JOUR. T1 - Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment. AU - Koh, Susan. AU - Nelson, Marvin D.. AU - Kovanlikaya, Arzu. AU - Chen, Lan. PY - 1999. Y1 - 1999. N2 - Intrathecal chemotherapy with methotrexate or cytosine arabinoside is the standard approach to prophylaxis and treatment of central nervous system leukemia in children. Progressive paraplegia, one of the devastating neurologic complications related to this mode of treatment, has been attributed to spinal cord toxicity. Reported are three children who developed progressive paraparesis after intrathecal methotrexate administration followed by complete or partial recovery. Gadolinium enhancement of anterior lumbosacral spinal nerve roots was demonstrated in all three patients, and an elevation of cerebrospinal fluid immunoglobulin G synthesis was evident in two patients with more severe symptoms. The clinical data suggest that anterior lumbosacral radiculopathy is also a type of neurologic ...
Composite of the following events through one month: initiation of the index endovascular procedure following the debranching procedure, device technical success for the index endovascular procedure and absence of the following Core Lab and adverse events: aortic rupture, lesion related mortality, disabling stroke, permanent paraplegia, permanent paraparesis, new onset renal failure requiring permanent dialysis, additional unanticipated post-procedural surgical or interventional procedure related to the device, procedure, or withdrawal of the delivery system ...
Paraplegia adalah suatu kelainan saraf yang mengakibatkan kehilangan fungsi sensorik (sensasi) serta motorik (gerak) di tungkai bawah. Akibatnya, penderita paraplegia bakalan mengalami kelumpuhan di kedua kaki. Paraplegia seringkali terjadi pada…. ...
POSADA-VERGARA, Maria Paulina et al. Clinical and epidemiological aspects of HTLV-II infection in São Paulo, Brazil: presence of Tropical Spastic Paraparesis/HTLV-Associated Myelopathy (TSP/HAM) simile diagnosis in HIV-1-co-infected subjects. Rev. Inst. Med. trop. S. Paulo [online]. 2006, vol.48, n.4, pp.207-210. ISSN 1678-9946. http://dx.doi.org/10.1590/S0036-46652006000400006.. In this study, the epidemiological and clinical features observed in solely HTLV-II-infected individuals were compared to those in patients co-infected with HIV-1. A total of 380 subjects attended at the HTLV Out-Patient Clinic in the Institute of Infectious Diseases "Emilio Ribas" (IIER), São Paulo, Brazil, were evaluated every 3-6 months for the last seven years by infectious disease specialists and neurologists. Using a testing algorithm that employs the enzyme immuno assay, Western Blot and polymerase chain reaction, it was found that 201 (53%) were HTLV-I positive and 50 (13%) were infected with HTLV-II. ...
Spinal epidural hematoma is bleeding into the epidural space in the spine. These may arise spontaneously (e.g. during childbirth), or as a rare complication of epiduralanaesthesia or of surgery (such as laminectomy).[citation needed] Symptoms usually include back pain which radiates to the arms or the legs. They may cause pressure on the spinal cord or cauda equina, which may present as pain, muscle weakness, or dysfunction of the bladder and bowel. The best way to confirm the diagnosis is MRI. Risk factors include anatomical abnormalities and bleeding disorders. Treatment is generally with emergency surgery. The risk following epidural anaesthesia is difficult to quantify; estimates vary from 1 per 10,000 to 1 per 100,000 epidural anaesthetics.[citation needed] The anatomy of the epidural space is such that spinal epidural hematoma has a different presentation from intracranial epidural hematoma. In the spine, the epidural space contains loose fatty tissue and a network of large, thin-walled ...
Pelvic lipomatosis is a rare disease that is most often seen in older obese black men with hypertension. In pelvic lipomatosis, abnormally dense deposits of otherwise apparently normal fat may be observed in the spaces of the pelvic area. Associated with cystitis glandularis, a precursor to adenocarcinoma of the urinary bladder. Fogg LB, Smyth JW. Pelvic lipomatosis: a condition simulating pelvic neoplasm. Radiology. 1968;90:558. http://www.medscape.com/viewarticle/417016_print An example of aggressive pelvic lipomatosis Lipoma ...
Asymmetrical motor examination: Asymmetrical motor function is age dependent but usually evident. In older children one expects to find clear asymmetry in strength that may or may not be realized by the patient. In toddlers who are still walking, frequent falling to one side or loss of arm swing will be seen. In infants there will be an asymmetry in muscle tone. ...
Solitary osteochondroma is a very unusual cause of spinal cord compression. The tumor is benign, and surgical removal produces an excellent clinical result. We have experienced a case of solitary osteochondroma in the posterier neural arch of the 11th thoracic vertebra which compressed spinal cord and resulted in paraparesis. Plain spine x-ray revealed calcified bony lesion with smooth border at Tll level. Myelogram showed nearly complete blockage of dye column, extradural type, at the Tll level. Total laminectomies including the pathological lesion resulted in excellent recovery ...
The format of this leaflet was determined by the Ministry of Health and its content was checked and approved by it in May WARNING: (A) PREMATURE DISCONTINUATION OF XARELTO INCREASES THE RISK OF THROMBOTIC
This is a remarkable healing case story of a strong-willed woman, Kalaivani who recovered fully from progressive spastic paraparesis, dysesthesia, myelopathy and bilateral hip osteoarthritis using natural medicine. Kalaivani was hobbled by four severe debilitating diseases of the nervous system… ...
TY - JOUR. T1 - The role of stereotactic radiosurgery in the treatment of intramedullary spinal cord neoplasms. T2 - a systematic literature review. AU - Hernández-Durán, Silvia. AU - Hanft, Simon. AU - Komotar, Ricardo J. AU - Manzano, Glen. PY - 2015/7/30. Y1 - 2015/7/30. N2 - Advances in imaging technology and microsurgical techniques have made microsurgical resection the treatment of choice in cases of symptomatic intramedullary tumors. The use of stereotactic radiosurgery (SRS) for spinal tumors is a recent development, and its application to intramedullary lesions is debated. We conducted a literature search through PubMeds MeSH system, compiling information regarding intramedullary neoplasms treated by SRS. We compiled histology, tumor location and size, treatment modality, radiation dose, fractionation, radiation-induced complications, follow-up, and survival. Ten papers reporting on 52 patients with 70 tumors were identified. Metastatic lesions accounted for 33 %, while 67 % were ...