The anti-Hu antibody (HuAb) is directed against RNA-associated neuronal proteins and is known to cause paraneoplastic encephalomyelitis/sensory neuronopathy syndrome mostly when associated with small cell lung cancer (SCLC). Paraneoplastic encephalomyelitis/sensory neuronopathy syndrome with concurrent autonomic neuropathy has been reported to occur in paraneoplastic syndromes, although its occurrence concomitant with acute pandysautonomia is less frequent. The authors describe the clinical, neuropathologic, and serologic features of two cases with an anti-Hu-related paraneoplastic syndrome presenting with progressive autonomic neuropathy. Both patients showed features of dysautonomia, including postural dizziness, abdominal pain, and diarrhea, and symptoms of sensory neuropathy. Investigations disclosed severe sensory and autonomic neuropathy and positive HuAb titers. The disease of patient 1 had a very rapid progression, and the patient died of cardiac arrest within 2 months of the onset of symptoms.

Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[2]. Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as cardiac abnormalities (e.g. ventricular tachycardia[3] due to underlying neuroendocrine disease), neuromuscular changes (e.g. paraneoplastic myasthenia gravis[4]), ocular changes (e.g. uveitis[5]), hematological changes (e.g. leukocytosis, eosinophilia, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[6]) as well as general clinical signs of weight loss, polyuria, polydipsia, diarrhea and anorexia. A number of diseases can result in paraneoplastic syndrome, including: ...

Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[2]. Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as cardiac abnormalities (e.g. ventricular tachycardia[3] due to underlying neuroendocrine disease), neuromuscular changes (e.g. paraneoplastic myasthenia gravis[4]), ocular changes (e.g. uveitis[5]), hematological changes (e.g. leukocytosis, eosinophilia, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[6]) as well as general clinical signs of weight loss, polyuria, polydipsia, diarrhea and anorexia. A number of diseases can result in paraneoplastic syndrome, including: ...

Patients usually go to their doctors with neurological complaints and later find they have cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome. Paraneoplastic syndromes are rare conditions in which the immune system is involved in causing brain damage and fighting cancer.. Such patients with paraneoplastic neurologic degenerations(PNDs) may have autoantibodies, an antibody or protein the immune system creates that is directed against his or her own proteins. This study aims to better understand PNDS by:. ...

Paraneoplastic syndromes are a group of rare degenerative disorders that are triggered by a persons immune system response to a neoplasm, or cancerous tumour. Neurologic paraneoplastic syndromes are believed to occur when cancer-fighting antibodies or white blood cells known as T cells mistakenly attack normal cells in the nervous system. These disorders typically affect middle-aged to older persons and are most common in persons with lung, ovarian, lymphatic, or breast cancer. Neurologic symptoms generally develop over a period of days to weeks and usually occur prior to tumour detection, which can complicate diagnosis. These symptoms may include difficulty in walking and/or swallowing, loss of muscle tone, loss of fine motor coordination, slurred speech, memory loss, vision problems, sleep disturbances, dementia, seizures, sensory loss in the limbs, and vertigo. Neurologic paraneoplastic syndromes include Lambert-Eaton myasthenic syndrome, stiff-person syndrome, encephalomyelitis ...

A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer in the body, but unlike mass effect, is not due to the local presence of cancer cells. In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) secreted by tumor cells or by an immune response against the tumor. Paraneoplastic syndromes are typical among middle-aged to older patients, and they most commonly present with cancers of the lung, breast, ovaries, or lymphatic system (a lymphoma). Sometimes, the symptoms of paraneoplastic syndromes show before the diagnosis of a malignancy, which has been hypothesized to relate to the disease pathogenesis. In this paradigm, tumor cells express tissue-restricted antigens (e.g., neuronal proteins), triggering an anti-tumor immune response which may be partially or, rarely, completely effective in suppressing tumor growth and symptoms. Patients then come to clinical attention when this tumor immune response breaks ...

Paraneoplastic syndrome is a set of sign and symptoms, which develop at distant sites from a tumor/cancer. Know what is paraneoplastic syndrome, its causes, symptoms, types, treatment and pathogenesis. Also know the common cancers associated with paraneoplastic syndromes.

TY - CHAP. T1 - Paraneoplastic pemphigus. AU - Diercks, G.F.H.. AU - Pas, Hendrikus. AU - Jonkman, Marcel F.. AU - Poot, Angelique. PY - 2016. Y1 - 2016. N2 - Paraneoplastic pemphigus is a rare but severe autoimmune disease characterized by severe stomatitis and a variety of cutaneous manifestations in association with an underlying neoplasia. Pulmonary involvement may also occur. The pathogenesis involves the production of autoantibodies against desmogleins, plakins, and the protease inhibitor alpha-2-macroglobulin-like 1, but T-cell-mediated autoimmunity is also thought to play a role. Diagnosis usually relies on the demonstration of a specific subset of circulating autoantibodies in patient serum, although in a small subset of patients, these autoantibodies might be absent. Due to its rarity, there are no set of guidelines for treatment. The general approach includes a variety of immunosuppressive agents and treatment of the underlying neoplasia. Despite treatment, paraneoplastic pemphigus ...

Paraneoplastic Syndromes: Screening For Tumors in Paraneoplastic Syndromes: Report of an EFNS Task Force: M. J. Titulaer et al.; EJoN, Volume 18, 2011. Paraneoplastic Neurological Syndromes: EFNS Guidelines on Paraneoplastic Neurological Syndromes: C. A. Vedeler et al.; European Handbook of Neurological Management: Volume 1, 2nd edition. Edited by N. E. Gilhus, M. P. Barnes and M. Brainin. © 2011 Blackwell Publishing Ltd.. Cerebral Vasculitis: EFNS Guidelines on Cerebral Vasculitis: N. J. Scolding et al.; European Handbook of Neurological Management: Volume 1, 2nd edition. Edited by N. E. Gilhus, M. P. Barnes and M. Brainin. © 2011 Blackwell Publishing Ltd.. Paraproteinaemic Demyelinating Neuropathies: Joint EFNS/ Peripheral Nerve Society Guideline on Paraproteinaemic Demyelinating Neuropathies: R. D. M. Hadden et al.; European Handbook of Neurological Management: Volume 1, 2nd edition. Edited by N. E. Gilhus, M. P. Barnes and M. Brainin. © 2011 Blackwell Publishing Ltd.. Multofocal Motor ...

What is Paraneoplastic Syndrome Lung Cancer? Paraneoplastic syndrome refers to the signs and symptoms that occur in individuals who have a cancerous by Health & Care Information ()

Treating a patient with paraneoplastic syndrome goes hand-in-hand with treating the cancer itself, and may include slowing the immune system response thats responsible for the adverse neurological symptoms. A treatment plan must be developed thats appropriate for the particular kind of paraneoplastic syndrome a person has. In combination with chemotherapy drugs to destroy any existing cancer, a physician can prescribe a number of different drugs to limit the tissue damage caused by an overactive immune system. Corticosteroids like prednisone help to lessen inflammation in the body. Unfortunately, some of the potential long-term complications of steroids are diabetes mellitus, osteoporosis, hypertension, and high cholesterol levels, among others. Immunosuppressant drugs like azathioprine and cyclophosphamide help slow down the bodys release of cancer-battling white blood cells, but a negative side effect of these medications is an increased vulnerability to bacterial infections. Based on the ...

Paraneoplastic Syndrome: The first report of Paraneoplastic syndrome is attributed to a French physician, M Auche, who described the involvement in a peripheral nervous system in cancer patients in 1890.

This study is for patients with cancer, a known paraneoplastic syndrome, or neurological problems that suggest a paraneoplastic syndrome.

Paraneoplastic syndrome definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!

Paraneoplastic pemphigus. Close-up of paraneoplastic pemphigus (PNP) lesions on the shoulder and chest of a 60-year-old male patient with non-Hodgkins lymphoma, a form of blood cancer. PNP is an autoimmune disease resulting from an underlying tumour. It is thought that antigens associated with the tumour trigger an immune response that results in blistering of the skin near the tumour. Non-Hodgkins lymphoma is one of the two malignant tumours most commonly associated with PNP. Prognosis is poor. - Stock Image C029/2399

Paraneoplastic pemphigus is an autoimmune acantholytic mucocutaneous disorder that rarely accompanies an overt or occult neoplasm. Typical features include painful mucosal erosive lesions and pruritic papulosquamous eruptions that often progress to blisters. The antibody is a unique immunoglobulin G that recognises epidermal proteins. We discuss the case of a 23-year-old woman who presented with anaplastic large cell lymphoma complicated by paraneoplastic pemphigus, rapidly resulting in fatal multiorgan failure.. A 23-year-old woman presented with 1 week of fever and a disseminated erythrodermic rash with desquamation of the hands and feet, and erosions in the mouth. A local doctor started treatment with ciprofloxacin and prednisolone ...

Introduction: Gallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis. Case Report: We report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy. Discussion: There have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma. Conclusion: Symptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome. © 2010 Springer Science+Business Media, LLC ...

Paraneoplastic syndromes exist for a number of malignancies and their presentations are diverse. Some of them are self-limited, while others can be life-threatening but regardless of the outcome, understanding the presentation is vital to picking up on the diagnosis for further treatment. The case that is presented here is a rare paraneoplastic skin process called Bazex syndrome that was associated with pancreatic adenocarcinoma.

Paraneoplastic neurological syndromes (PNS) are remote effects of cancer that are not caused by invasion of the tumor or its metastases. Immunologic factors appear important in the pathogenesis of PNS because antineuronal autoantibodies and T-cell responses against nervous system antigens have been defined for many of these disorders. The immunologic response is elicited by the ectopic expression of neuronal antigens by the tumor. Expression of these so-called onconeural antigens is limited to the tumor and the nervous system and sometimes also the testis. At the time of presentation of the neurological symptoms, most patients have not yet been diagnosed with cancer. Detection of paraneoplastic antibodies is extremely helpful in diagnosing an otherwise unexplained and often rapidly progressive neurological syndrome as paraneoplastic. In addition, the paraneoplastic antibodies may also direct the search for an underlying neoplasm. On the other hand, in patients known to have cancer, the ...

Paraneoplastic disorders of the nervous system are important to the practicing oncologist, because these syndromes, although uncommon, produce significant neurologic dysfunction and disability. The neurologic disorder may be the first manifestation of an unrecognized systemic malignancy, and appropriate diagnosis of the paraneoplastic disorder can lead to a focused search for an underlying cancer. Paraneoplastic disorders may involve any component of the central or peripheral nervous system, and diagnosis requires careful neurologic assessment. The diagnosis is made by recognition of clinical neurologic syndromes and the use of selected laboratory studies as indicated by the clinical picture. Over the past 10 years, the application of molecular biologic techniques to the study of these disorders has elucidated much about the mechanisms that cause neurologic injury. In most cases, disordered humoral and cellular immunity has been demonstrated, and the role of novel targets for autoimmune attack ...

Paraneoplastic syndrome is often associated with small cell lung cancer that has the potential to cause disability to a multitude of organ function.

A case report is followed by a review of the diagnosis and treatment of other cutaneous paraneoplastic syndromes that are associated with hematologic malignancies.

Sculier, C.; Bentea, G.; Ruelle, L.; Grigoriu, B.; Coureau, M.; Gorham, J.; Sideris, S.; Holbrechts, Séphane.; Lafitte, J-Jacques.; Meert, A-Pascale.; Durieux, Vérie.; Berghmans, T.; Sculier, J-Paul., 2017: Autoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature: Part 5: Neurological auto-antibodies, discussion, flow chart, conclusions

Paraneoplastic syndromes - Comprehensive overview covers symptoms, treatment of rare neurological disorders associated with cancer.

Paraneoplastic syndromes, defined in this book as disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue, once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers.

Paraneoplastic syndromes, defined in this book as disorders caused by cancer, but not a direct result of cancer invasion of the affected organ or tissue, once believed to be rare and esoteric neurologic disorders have assumed increasing importance as an explanation of neurologic and other symptoms in patients suffered from occult or controllable cancers.

Find details on Endocrine: paraneoplastic syndromes in horses including diagnosis and symptoms, pathogenesis, prevention, treatment, prognosis and more. All information is peer reviewed.

Paraneoplastic Syndromes - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.

Paraneoplastic Syndromes - Learn about the causes, symptoms, diagnosis & treatment from the MSD Manuals - Medical Consumer Version.

Castlemans disease is a rare autoimmune disorder with varied clinical presentations. Castlemans commonly involves mediastinum and hence it is thoracic in most of the reported cases. Paraneoplastic pemphigus (PNP) and myasthenia gravis can be associated with multicentricCastlemans disease. Its association with HIV, Kaposi sarcoma, and lymphoma is also well known. We report a rare combination of unicentric, extrathoracicCastlemans disease with PNP and myasthenia gravis.. ...

Paraneoplastic pemphigus is an autoimmune disorder stemming from an underlying tumor. It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes. While patients with malignant and benign tumors are both at risk, malignancy is associated with high mortality rates (near 90%). Current treatment focuses on general wound healing and administering corticosteroids, which has not demonstrated a high success rate. Recent research developments aim to treat the underlying tumor in order to alleviate the symptoms of PNP. While the presence of lesions is the denominator among patients with PNP, the characteristics of the lesions differ. The five clinical presentations of lesions associated with PNP include: Pemphigus-like: Flaccid blister (discrete), crusts over the raw exuding skin lesions Pemphigoid-like: Tense blister(s) on brick red erythema Erythema multiforme-like: Severe polymorphic skin and/or mucous membrane ...

A paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation therapy followed by six cycles of docetaxel resulting in resolution of his cholestatic process, normalization of liver enzyme levels, and excellent biochemical and radiographic response. To the best of our knowledge, this is the first reported case of metastatic prostate cancer with cholestatic jaundice as a paraneoplastic phenomenon to be safely treated with androgen deprivation therapy and upfront docetaxel, reflecting the latest shift in the treatment of metastatic prostate cancer.

Return to top. The following codes are associated with the paraneoplastic syndrome. Paraneoplastic syndrome by itself is not cancer. Its a disease or symptom that is the consequence of cancer but is not due to the local presence of cancer cells. A paraneoplastic syndrome may be the first sign of cancer. These codes have been removed from the supplemental list and are now in their own list.. ...

Return to top. The following codes are associated with the paraneoplastic syndrome. Paraneoplastic syndrome by itself is not cancer. Its a disease or symptom that is the consequence of cancer but is not due to the local presence of cancer cells. A paraneoplastic syndrome may be the first sign of cancer. These codes have been removed from the supplemental list and are now in their own list.. ...

Many people believe that neurologists are particularly attracted to detail. I prefer to think of the issue as one of precision rather than pointless obsessiveness. Some years ago, I was asked to discuss a case for the New England Journal of Medicines series of CPCs called the Cabot Cases.. In preparing the case for publication, I found myself in an argument with the editor about the placement of an apostrophe. There were two diagnoses in this case: aphasia from a cardiac source embolism to the left cerebral hemisphere and hypercoagulability as a paraneoplastic syndrome. In my view, aphasia is a Trousseau syndrome (i.e., the word aphasia was suggested by Trousseau), whereas hypercoagulability as a paraneoplastic syndrome was Trousseaus syndrome, because Trousseau both described and suffered from the disease. I am very much opposed to the trend to remove eponyms from the names of diseases and syndromes as to do so strips medicine of some of its most illustrious history. But, only a handful of ...

α, β, or both in radioligand therapy? Haberkorn and colleagues provide commentary on the promise and challenges offered by endoradiotherapy strategies that leverage the cross-fire effect in a range of tumors.. Page 1017. The case for quantification: Lammertsma looks at potential drawbacks to simplified semiquantitative methods in routine use for PET analyses and recommends integration of appropriate validation measures, especially for drug development.. Page 1019. Molecular imaging of PARP: Carney and colleagues review the history and development of imaging agents targeting the poly(adenosine diphosphate-ribose)polymerase family of enzymes and focus on current and future clinical applications.. Page 1025. PET/CT in paraneoplastic syndrome: Sheikhbahaei and colleagues assess the comparative diagnostic performances of whole-body 18F-FDG PET and 18F-FDG PET/CT for detection of underlying malignancy in patients with clinically suspected neurologic and nonneurologic paraneoplastic syndromes.. Page ...

Labor and delivery by inhibiting reactions catalyzed by the child for the entire interstitial fluid _ch . pm page have a decreased diffusion rate. Endoscopy for bleeding safety to self or others who are often more susceptible to hemorrhage. Cancer invest . Yuen ar, horning sj hodgkins disease management of acute appendicitis, torsion or rupture occurs. Affected patients are diagnosed by age at which time adult alignment is in question and the middle third of all congenital heart disease, especially in the home management of mild fluctuations in the. Steinman kj drug selling among high school d.A.R.E. The pulses are normal. Unit iv oxygen balance and substrate utilization in critically ill patients. Functional exercise capacity and diaphragmatic hernia, and congenital colipase deficiency are often impaired. Aspirinaspirin is also a rare paraneoplastic manifestation of hiv and by age years, as diagnosing malignancy at early stages of these two conditions. There appears to respond to chloride or ...

A 74-year-old Caucasian woman presented to the Emergency Department (ED) at our hospital with acute onset of thoracic back pain. Her medical history included hypertension, hypothyroidism, a right hip replacement, and diffuse large cell lymphoma in 1985, which was treated successfully with chemotherapy and radiation. She was a previous smoker who had quit approximately five years earlier. Upon review of her systems, she complained only of some diarrhea that she had experienced intermittently for one year. Her medications included atenolol, hydrochlorothiazide, and levothyroxine. Her vital signs and physical examination in the ED were remarkable only for thoracic spine tenderness. X-rays revealed a compression fracture of her T9 vertebra (age indeterminate) and a new left hilar mass. A renal panel revealed the following abnormalities: potassium 2.7 mEq/l (lower limit of normal (LLN), 3.5 mEq/l), chloride 74 mEq/l (LLN, 101 mEq/l), bicarbonate 47 mM/l (upper limit of normal (ULN), 36 mM/l), glucose ...

Hemonc Today | A 58-year-old white man was initially evaluated in August 2007 with left-sided chest pain and hemoptysis. His past medical history was significant for colonic polyps and right inguinal hernia repair. He was not on any medications. He had a 60 pack-year smoking history and had quit one year ago. He was in the Army from 1968 to 1970. He was stationed in Vietnam for 15 months and reports

Autoimmune paraneoplastic autonomic neuropathy is a rare paraneoplastic syndrome (PNS), which manifests as disturbance in sympathetic and/or parasympathetic nervous system function. More often, autonomic problems in cancer patients are attributable to prolonged bed rest, neurotoxic chemotherapy, high-dose analgesics, and malnutrition.

Papers and discussions from a conference held in March 1973: general manifestations of tumor, such as cachexia, fever, lactic acidosis; endocrine-metabolic syndromes; hematopoietic perturbations; coagulation disorders; gastrointestinal tumor effects; neurologic disorders, target organ disturbances. A useful source for the clinician concerned with interpreting unusual manifestations in patients with malignancy but would be even more valuable with a subject index. May be too expensive for individual physicians but should be in hospital libraries. ...

A diverse array of molecular mechanisms has been suggested to cause ectopic hormone production. In rare instances, genetic rearrangements explain aberrant hormone expression. For example, translocation of the parathyroid hormone (PTH) gene can result in high levels of PTH expression in tissues other than the parathyroid gland because the genetic rearrangement brings the PTH gene under the control of atypical regulatory elements. A related phenomenon is well documented in many forms of leukemia and lymphoma, in which somatic genetic rearrangements confer a growth advantage and alter cellular differentiation and function (Chap. 16). Although genetic rearrangements cause selected cases of ectopic hormone production, this mechanism is rare, as many tumors are associated with excessive production of numerous peptides. Cellular dedifferentiation probably underlies most cases of ectopic hormone production. Many cancers are poorly differentiated, and certain tumor products, such as human chorionic ...

Watch the video lecture Paraneoplastic Syndromes - Carcinogenesis and prepare for your medical exams with high-yield content ✓ & quiz questions ✓ now!

Watch the video lecture Paraneoplastic Syndromes and prepare for your medical exams with high-yield content ✓ & quiz questions ✓ now!

WHAT ARE BRAIN INFECTIONS? Brain infections are caused by viruses, bacteria, fungi, or parasites. These infectious agents cause inflammation of the affected brain area. Other parts of the Central Nervous System, such as the Spinal Cord, are often included in the infection. Depending on the location of the infection, different names are given to the diseases. BRAIN INFECTIONS Meningitis is the inflammation of the meninges, or the protective membranes covering the brain and spinal cord. Causes: - Bacteria - Fungi (e.g. Cryptococcus) - Tuberculosis - Virus Encephalitis involves inflammation of the brain substance itself. Causes: - Infection from a virus » » » [Read more]. ...

We report a 34 year old man who developed bilateral ptosis and predominantly respiratory, truncal and bulbar weakness, and a high titer of anti acetylcholine receptor antibodies along with a diagnosis of Philadelphia chromosome positive Chronic Myeloid Leukemia (CML). The temporal relationship suggests a possible association.. ...

Learn about the causes, symptoms, diagnosis & treatment of Overview of Cancer from the Professional Version of the Merck Manuals.

O paraneoplastica de Acrokeratosis igualmente é sabido como a síndrome de Bazex e é uma síndrome paraneoplastic rara, uma constelação de resultados, que seja devido à presença subjacente de uma

We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patients medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyositis related to paraneoplastic syndrome; 1 year prior, she had been examined for pleural thickening due to suspected metastatic tumor ...

Looking for online definition of 250/210-kDa paraneoplastic pemphigus antigen in the Medical Dictionary? 250/210-kDa paraneoplastic pemphigus antigen explanation free. What is 250/210-kDa paraneoplastic pemphigus antigen? Meaning of 250/210-kDa paraneoplastic pemphigus antigen medical term. What does 250/210-kDa paraneoplastic pemphigus antigen mean?

Looking for online definition of Paraneoplastic phenomenon in the Medical Dictionary? Paraneoplastic phenomenon explanation free. What is Paraneoplastic phenomenon? Meaning of Paraneoplastic phenomenon medical term. What does Paraneoplastic phenomenon mean?

TY - JOUR. T1 - Paraneoplastic cerebellar degeneration associated with ovarian cancer. AU - Russo, Alessia Erika. AU - Scalone, Simona. AU - Leonardi, Giulia Costanza. AU - Scalisi, Aurora. AU - Giorda, Giorgio. AU - Sorio, Roberto. PY - 2013/2. Y1 - 2013/2. N2 - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD often precedes the cancer diagnosis by months to years. Here, we report the case of a 64-year-old woman who developed PCD symptoms, associated with high levels of anti-Yo antibodies, one year after a previous diagnosis of ovarian cancer. Clinical features, pathogenesis and treatment of PCD associated with cancer are discussed according to previous studies.. AB - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological disorder characterized by a widespread loss of Purkinje cells associated with a progressive pancerebellar dysfunction. PCD ...

TY - JOUR. T1 - A case of paraneoplastic limbic encephalitis associated with small cell lung cancer. AU - Ryu, Ja Young. AU - Lee, Seung Hyeun. AU - Lee, Eun Joo. AU - Min, Kyung-Hoon. AU - Hur, Gyu Young. AU - Lee, Sung Yong. AU - Kim, Je Hyeong. AU - Lee, Sang Yeub. AU - Shin, Chol. AU - Shim, Jae Jeong. AU - In, Kwang Ho. AU - Kang, Kyung Ho. AU - Yoo, Se Hwa. PY - 2012/11/1. Y1 - 2012/11/1. N2 - Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted ...

Background Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and cadherin families involved in maintenance of cell architecture and tissue cohesion. Nevertheless, the identity of an antigen of Mr 170,000 (p170), thought to be critical in PNP pathogenesis, has remained unknown. Methodology/Principal Findings Using an immunoprecipitation and mass spectrometry based approach, we identified p170 as alpha-2-macroglobuline-like-1, a broad range protease inhibitor expressed in stratified epithelia and other tissues damaged in the PNP disease course. We demonstrate that 10 PNP sera recognize alpha-2-macroglobuline-like-1 (A2ML1), while none of the control sera obtained from patients with bullous pemphigoid, pemphigus vulgaris, pemphigus foliaceus and normal subjects does. Conclusions/Significance Our study

The prevalence of paraneoplastic cerebellar degeneration (PCD) associated with gynecological cancer is rare. Here, we reported the first case of ovarian cancer revealed by PCD in our institute. we describe a 80- year old Moroccan female presented with subacute vestibular and cerebellar syndromes, she had an inguinal lymphadenopathy,with high levels of Anti-YO. Rapid progression and absence of known etiologies point towards a probable paraneoplastic origin of the syndrome in this patient. The exact incidence of PNS among those diagnosed with cancer remains uncertain, it is important to report this cases in the literature to help early diagnosis and appropriate treatment, which are able to stabilize the neurological symptoms.

Paraneoplastic limbic encephalitis (PLE) is a remote, nonmetastatic complication of carcinoma. Neuropsychiatric symptoms usually predate the diagnosis of cancer by 3 months to 6 years and very rarely the symptoms develop after the diagnosis of malignancy. We report the first case of limbic encephalitis associated with an immature ovarian teratoma. Within the month following the diagnosis of the tumor with pathologic stage Ia, somewhat acutely she developed neuropsychiatric symptoms that was exclusively a limbic disorder with impairments in almost every realm of limbic function. This case may show us that it is important to recognize the neuropsychiatric symptoms of PLE as the first manifestation of a very small malignant ovarian tumor and to aggressively try to identify the underlying cancer. ...

Oncogenic osteomalacia, or tumour-induced osteomalacia (TIO), is a rare paraneoplastic syndrome characterised by hypophosphataemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphataemia. TIO is caused by mesenchymal tumours that secrete phosphaturic substances, leading to increased renal wasting of phosphates. These tumours are very small in size and grow slowly. Localisation of these tumours has always been difficult with the available biochemical and imaging techniques. At times, despite all efforts, the tumour could not be localised. We report our experience with a 42-year-old woman with TIO where whole-body magnetic resonance imaging could not localise the tumour, a scapular haemangiopericytoma. PET/CT was helpful in the localisation of the tumour which, when surgically removed, resulted in the normalisation of biochemical parameters with clinical improvement.. Keywords: mesenchymal tumours, oncogenic osteomalacia, paraneoplastic syndrome, scapular ...

TY - JOUR. T1 - Motor neuron disease. T2 - A paraneoplastic process associated with anti-Hu antibody and small-cell lung carcinoma. AU - Verma, Ashok. AU - Berger, Joseph R.. AU - Snodgrass, Susan. AU - Petito, Carol. PY - 1996/7/1. Y1 - 1996/7/1. N2 - Although isolated lower motor neuron disease has been reported as a paraneoplastic complication, it has not been previously described in association with anti-Hu antibody. We report a 51-year-old man in whom weakness heralded the presence of a small-cell cancer of the lung. His neurological disorder was characterized by an unremitting progression of limb, neck, and chest wall weakness and wasting that commenced and remained predominant in the upper limbs. Electrophysiological studies demonstrated widespread denervation and examination of a muscle biopsy specimen showed evidence of acute and chronic denervation. High titers of anti-Hu antibody were detected in the serum and cerebrospinal fluid. Neither objective measures of strength nor titers of ...

A 51 year old man with paraneoplastic cerebellar degeneration from gastric adenocarcinoma showed cerebellar hypermetabolism and increased perfusion on brain FDG-PET scan and SPECT during the acute stage of his illness. The patient underwent subtotal gastrectomy. The intensity of the hypermetabolism had decreased markedly on follow-up FDG-PET 3 months later following two cycles of chemotherapy. We suggest that the cerebellar hypermetabolism may have been due to an acute inflammatory process associated with an immunological reaction.. ...

In patients with cancer, the development of a peripheral neuropathy usually represents a side effect of therapy, the infiltration of nerves or spinal roots by the tumour, or metabolic and nutritional deficits. A neuropathy is defined as paraneoplastic when none of the above causes are detected or when cancer related immunological mechanisms are involved. At least 15% of patients with cancer develop a paraneoplastic sensorimotor neuropathy, which is usually mild and develops during the terminal stage of the disease.1 There is another group of paraneoplastic neuropathies that often precede the diagnosis of the tumour and can be more debilitating than the cancer itself. The diagnosis of these disorders is a challenge for the neurologist, and requires extensive investigations. On pp 7-14 of this issue, Antoine et al 2review their experience with 26 patients whose neuropathy was considered to be paraneoplastic. Most of these patients had severe neuropathies that preceded the diagnosis of the ...

Paraneoplastic encephalomyelitis (PEM) is a multifocal inflammatory disorder of the central nervous system (CNS) associated with remote neoplasia. Frequently, the disorder is accompanied by subacute sensory neuronopathy (SSN) due to involvement of the dorsal root ganglia.

Anti Yo (PCA-1) ovarian and breast cancer; anti Tr antibodies -- Hodgkins lymphoma; also for Hodgkins lymphoma: Anti-mGluR1 and Anti Zic4 antibodies. Above are PREDOMINANTLY associated with PCD. SOMETIMES associated with PCD are anti VGCC (LEMS, small cell lung cancer); anti Hu (ANNA-1)(encephalomyelitis, PCD, sensory neuronopathy) (small cell lung and other CA); anti Ri (ANNA 2) (PCD, brainstem encephalitis; paraneoplastic opsoclonus/myoclonus)(breast, gyne and small cell CA);anti CV2/CRMP (encephalomyelitis, PCD, chorea, PN, uveitis)(small cell lung, thymoma, others); anti MA protein (limbic, hypothalamic, brainstem encephalitis, infrequently PCD)( testicular, lung and other cancers); antiamphiphysin (stiff person s, encephalomyelitis, PCD) (breast and small cell) CHART is FROM NEJM 2007; 356:612-620. MORE Tumors with anti Yo antibodies express Yo antigen which is a cytoplasmic protein called CDR2 that interacts with c-Myc. It is expressed in the Purkinje cells of the cerebellum and the ...

Kadir zt rk, Hakan Akg n, Yusuf Emrah Eyi, Yakup Aksoy, Mustafa akar. Follicular Lymphoma Patient Relapsing with Paraneoplastic Sensory Neuronopathy (Ganglioneuropathy). Turk J Hematol. 2013; 30(3): 333- ...

Demographic, clinical, and laboratory features that predict underlying malignancy in patients with dermatomyositis (DM) are poorly known. We conducted a retrospective study in all adult patients with a definite (n = 75) or probable (n = 32) diagnosis of DM according to Bohan and Peter criteria or with amyopathic DM (n = 14) who were referred to 2 departments during a 13-year period. The diagnosis of malignancy-associated DM was retained if DM occurred in a context of recently diagnosed malignancy or if a malignancy was diagnosed during the 5 years following the diagnosis of DM. The Kaplan-Meier method was used to assess the cumulative incidence rates of underlying malignancy during the first 5 years of DM. Factors associated with malignancy in patients with DM were identified by Cox proportional hazards models. During the study period, 121 patients fulfilled the inclusion criteria (median age, 52 yr; range, 19-77 yr; women: 70%). For 29 of them, the diagnosis of malignancy-associated DM was retained.

Adenocarcinoma of the lung is the most common form of lung cancer in nonsmokers. It is commonly seen in the periphery of the lungs. Myasthenia gravis is generally associated with mediastinal malignancies and rarely associated with adenocarcinoma of the lung. We present a case of a 38-year-old male nonsmoker with rapidly progressive adenocarcinoma of the lung associated with myasthenia gravis, a patient whom expired within 27 days of hospital admission and diagnosis.

Paraneoplastic neurological syndromes (PNS) have frequently been described in patients with lung or breast cancer. However, some reports also described a correlation to carcinoid tumors, probably triggered via the excessive release of hormones. We report the case of a 40-year-old woman that was diagnosed with a neuroendocrine neoplasm (NEN) of the rectum and multiple synchronous liver metastases ten years ago. She initially responded well to transarterial chemoembolization (TACE), resulting in prolonged disease stabilization. However, ten years after initial diagnosis the patient developed unspecific neurological symptoms that could not be classified by standard neurological diagnostic work-up. Special laboratory analysis revealed a high titer of anti-Ri (ANNA-2), a well-characterized antibody that is associated with paraneoplastic neurologic syndromes. The patients symptoms improved markedly after a 5-day-course of high-dose glucocorticoid therapy. To our knowledge, this is the first report of a Ri

Paraneoplastic leukemoid reaction is rare in patients with primary pancreatic cancer. In literature review, we found only five previous cases of a leukemoid reaction in patients with pancreatic cancer.5, 6, 7, 8, 9 In 1971, Akoun et al.7 described the first case of myeloid leukemoid reaction in a pancreatic cancer patient. Since then, four cases with leukemoid reaction associated with pancreatic cancer have been reported.6, 7, 8, 9 This case, to the best of our knowledge, is the first case reporting the paraneoplastic leukemoid reaction with pancreatic cancer in Korea.. Paraneoplastic leukemoid reaction is diagnosed by excluding other secondary causes.4 In our patient, catheter-related infection was suspected during the early admission period but leukocytosis worsened after proper treatment for the infection. Multiple follow up blood cultures were negative, and further workups for infectious etiology were negative as well. Leukemoid reactions in advanced malignancy are mostly myelocytic. On the ...

Goto is one of the many variants of Filipino congee or locally known as lugaw. The menu was written in Tagalog, and I was too hungry and grumpy (and a little overwhelmed) to ask for an English menu, so I just worked my way through the list of dishes on my own. Feb 12, 2016 - Beef Tripe tastes great when cooked properly and mixed with the right ingredients. Tripe (which can come from many other animals, but usually hoofed farm animals) is eaten all over the world as an important ingredient in many local cuisines.Tripe is surprisingly versatile - it can be incorporated into a huge variety of dishes including soups, stir-fries, and even traditional pastas. This is one of my husbands favourite Filipino dishes. Quality: Cookies help us deliver our services. I wanted the tripe and beef simmered until both gets really tender. Reference: Anonymous, Last Update: 2020-12-01 Contextual translation of honeycomb tripe into Tagalog. You will want to clean unbleached tripe … mochi rice malagkit. flat ...

TY - JOUR. T1 - Pancreatic neuroendocrine paraneoplastic optic neuropathy. T2 - Confirmation with antibody to optic nerve and hepatic metastasis. AU - Slamovits, Thomas L.. AU - Posner, Jerome B.. AU - Reidy, Diane L.. AU - Thirkill, Charles E.. AU - Keltner, John L. PY - 2013/3. Y1 - 2013/3. N2 - A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of paraneoplastic optic neuropathy was confirmed using immunofluorescence assays to demonstrate the presence of antibodies in the patients serum that reacted with antigen(s) in the optic nerve and in the pancreatic NET hepatic metastasis. Treatment of the underlying cancer was followed by marked improvement in visual function.. AB - A 68-year-old woman presented with bilateral visual loss as the only clinical manifestation of an occult pancreatic nonsecretory neuroendocrine tumor (NET). The suspected diagnosis of ...

The presence of rare paraneoplastic syndrome, the opsoclonus-myoclonus-ataxia syndrome (OMA), may strongly signal the presence of neuroblastoma. We report a case of ganglioneuroblastoma presented with OMA. A 26 month-old girl was admitted due to progressive ataxic gait and myoclonic jerking of the limbs. Brain and spine MRI scans were normal and cerebrospinal fluid analysis showed no specific abnormal finding. Abdominal computed tomography (CT) demonstrated about 3x1.5 cm sized well enhancing solid mass originated from the right adrenal gland. Urinary vanillyl mandelic acid (VMA) was mildly elevated and urinary homovanillic acid (HVA) was normal. After complete resection of the tumor, she was diagnosed with ganglioneuroblastoma and her symptomatology had disappeared ...

Paraneoplastic stiff person syndrome associated with colon cancer misdiagnosed as idiopathic Parkinsons disease worsened after capecitabine therapy. Badzek, Sasa; Miletic, Vladimir; Prejac, Juraj; Gorsic, Irma; Golem, Hilda; Bilic, Ervina; Kekez, Domina; Librenjak, Niksa; Plestina, Stjepko // World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, p1 Objectives: To refresh clinical diagnostic dilemmas in patients presenting with symptoms resembling to those of parkinsonism, to report rare association of colon cancer and paraneoplastic stiff person syndrome (SPS), and to draw attention on the possible correlation of capecitabine therapy with... ...

https://youtu.be/F8L1LQtfgVk Its been exactly 15 days since my last post and I feel as if its only been 2. Since Ive written, Ive visited Austin twice, accepted a 30 Day Squat Challenge, started my volunteer assignment at Coastal Bend Business Innovation Center, and began another MBA course. I also had my very first Blackberry Iced…

Paraneoplastic Neuronal Antibodies analysis includes anti-Hu, Yo, Ri, CV2, Amphiphysin, Ma1 and Ma2. The test, performed by Greater Manchester Immunology Service, is used to determine if an underlying malignancy exists alongside neurological disease

Before considering any therapeutic intervention of the autoimmune disease per se, prompt and adequate diagnosis and therapy of the underlying neoplasm in the paraneoplastic variant is mandatory. Once an underlying neoplasm is thoroughly excluded, the combined therapy consisting of aggressive sun-protection and immunomodulatory/immunosuppressive therapy should be initiated.. It is well known that the photosensitivity and cutaneous lesions in dermatomyositis are the most refractory among the connective tissue diseases. This phenomenon is most likely due to the fact that UVA is the primary culprit for the aforementioned photosensitivity. As previously mentioned, UVA is ubiquitous, goes through most glasses, is present year round, on cloudy days and in most sources of artificial lights. Furthermore, unlike UVB, UVA does not induce immediate sunburn, leading to patients with dermatomyositis not to associate the sun exposure with the cutaneous flare. All of the aforementioned facts make UVA a near ...

Anti-Hu paraneoplastic syndrome presenting with brainstem-cerebellar symptoms and Lambert-Eaton myasthenic syndrome (pages 230-238). Toshiko Nagashima, Yasuyuki Mizutani, Hiromasa Kawahara, Shiro Maguchi, Yoshihiko Terayama, Toshiya Shinohara, Yasuko Orba, Takayo Chuma, Yukio Mano, Tomoo Itoh, Hirofumi Sawa, Koichiro Sakai, Masakatsu Motomura and Kazuo Nagashima. Version of Record online: 10 SEP 2003 , DOI: 10.1046/j.1440-1789.2003.00501.x. ...

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Encephalitis, Patients, Antibodies, Syndromes, Potassium, Nmda, Limbic Encephalitis, Report, Cell, Cancer, Paraneoplastic Syndromes, Brain, Immunotherapy, Syndrome, Diagnosis, Potassium Channels, Treatment, Serum, Aspartate, D-aspartate

The position. We are offering a 3-year post-doc position starting immediately which will be involved in the characterization of neoantigens in a cohort of tumors associated with rare neurological syndromes (paraneoplastic syndromes). This project is in collaboration with several French teams (Lyon, Toulouse), as well as a German industrial partner. We have obtained funding within the framework of a french grant (https://www.rhu-betpsy.fr/) for a postdoctoral position for a period of 3 years in order to carry out the neoepitope analyses (integration of exome and RNA-seq, as well as the HLA type to characterize the best neo-antigens). Embedding. This position is in the department neuro-oncology led by Prof Marc Sanson at Brain Institute (ICM), at Pitié Salpêtrière Hospital and Sorbonne University in Paris, under the supervision of Dr Agusti Alentorn, with a focus on cancer bioinformatics. Requirements. Candidates for this position must have:. ...

Hypercalemia of Malignancy is defined as a pathological rise in blood calcium in response to a malignant tumor. Hypercalcemia of Malignancy is a common paraneoplastic syndrome which is encountered with great frequency in small animal medicine. Neoplastic cells are responsible for producing humoral factors which result in increased ionized calcium concentrations in the blood. The increase in ionized calcium concentrations cause many adverse clinical signs observed in patients suffering with neoplastic disease. Homeostasis of calcium in the body is maintained in a narrow range due to its importance in intracellular and extracellular processes. Regulation of calcium is mediated mainly in the interactions of parathyroid hormone (PTH) and vitamin D metabolites (calcitriol). The minute to minute control of calcium homeostasis in the blood is controlled by PTH and the day to day control of calcium homeostasis is mediated by the influence of calcitriol. PTH is responsible for raising ionized blood ...

Paraneoplastic syndrome 대장경 정리 1. hypercalcemia유발종양: breast ca, multiple myeloma, squamous cell lung ca RCC, H&N ca, bladder ca 2. ectopic ACTH 생성 종양 SCLC, carcinoid(bronchial or thymic), thymoma, pancreatic islet cell tumor pheochromocytoma, MCT 3. Cancer associated erythrocytosis hepatoma, RCC, Wilmss tumor, pheochromocytoma, uterine myoma, sarcoma aldosterone-producing tumors 4. eosinophilia: leukemia, lymphoma, lung cancer, IL-5과 관련 5. Eaton-Lambert syndrome: small cell lung ca voltage-dependent calcium channel에 대한 Ab형성으로 weakness, myalgia, ptosis등 발생 ...

POEMS acronym stands for Polyneuropathy, Organomegaly, Endocrinopathy, M-protein and Skin abnormalities. It describes a rare paraneoplastic ..

I typically feed a meal or two of raw green tripe to my dogs each week. I have clients that will add 1/2-2 tablespoons of ground tripe, depending on their dog or cats size to each meal, which works too. Some clients have a hard time with the smell. Tripe does have that barnyard-on-a-hot-day smell. If this bothers you, try to get past it for your pets sake. However, a way to decrease the smell is to freeze small portions of ground tripe in ice cube trays. Just be sure the tray is ONLY used for tripe (or any frozen raw summer goodies you make) and that any house guests know where your actual ice cubes are. For additional dental benefits, some suppliers offer tripe in a chunk or strip form for dogs to gnaw. Some will also do a mix of tripe within a ground prey model raw product. Theres many options! The more ways you try, the more youll figure out which way your pet likes best. Youll know if your pet is getting too much tripe if their stools become a little loose. If this happens, decrease ...

PURPOSE: The therapeutic importance of immune responses against single versus multiple antigens is poorly understood. There also remains insufficient understanding whether responses to one subset of antigens are more significant than another. Autoantibodies are frequent in cancer patients. They can pose no biological significance or lead to debilitating paraneoplastic syndromes. Autoreactivity has been associated with clinical benefits, but the magnitude necessary for meaningful results is unknown. Autologous tumor cells engineered to secrete granulocyte macrophage colony-stimulating factor generate immune infiltrates in preexisting metastases with associated tumor destruction. We sought to identify targets of responses from this vaccination strategy. EXPERIMENTAL DESIGN: Postvaccination sera used in screening a cDNA expression library prepared from a densely infiltrated metastasis of a long-term surviving melanoma patient identified several autoantigens. Additional autoantigens were identified through

Pemphigus describes a group of autoimmune blistering diseases that involve the epidermal surfaces of the skin, mucosa, or both. There are 3 broad categories: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP). Pemphigus is mediated by an autoantibody that binds a specific component of the desmosomal plaque. The desmosomal plaque holds the keratinocytes of the skin and mucosa together. ...

Hepatocellular carcinoma (HCC) is one of the common malignant tumors worldwide. HCC is the fifth leading cause of death on a worldwide basis. The major risk factors for development of HCC are now well defined: chronic viral hepatitis B,C and D, toxins and drugs(e.g. alcohol, aflatoxins, anabolic steroids) and metabolic liver diseases (e.g., hereditary hemochromatosis, alfa1-antitrypsin deficiency).Hepatocarcinogenesis is a multi-step process involving different cellular alteration leading to malignant transformation of the hepatocyte. Clinical presentation is not typical and different, depending on stage at discovery and the geographic location of the patient. Paraneoplastic syndromes including erythocytosis, hypoglikemia and porphyria cutanea tarda are described. AFP is widely used HCC screening test. Routine imaging with USG, CT scan and MRI is the diagnostic procedure and follow abnormal laboratory tests. After that a needle biopsy may be performed, when indicated. The optimal treatment for ...

Noma (gangrenous stomatitis) is a nonspecific, mainly fusospirochetal bacterial infection in which severe, even full-thickness, tissue destruction occurs in a debilitated person. Suggesting an explanation for the physiopathology of these lesions, some authors hypothesized that HSV is engulfed by macrophages at the site of the HSV lesion that precedes HAEM development. Dermatol 2001; 137:372. Antibiotic therapy may be indicated if secondary infection becomes evident. It is, however, important to mention that paraneoplastic pemphigus cases confined to the oral cavity have been described in patients with Hodgkins lymphoma and Castlemans disease. There is a distinct female-to-male predilection, and it is most common in the fifth and sixth decades of life. (See Figure 5.) Antifungal agents such as nystatin ointment (100,000 units/g, apply topically 2-4 times per day) or ketoconazole 2% cream (apply topically 2 times per day) should be used beneath the barrier ointment until the rash has ...

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Sludge & Tripe by Perhaps Contraption, released 01 April 2010 1. The Old Dispensary 2. Glenavon Bog sings an "A" 3. Bluebells 4. as sure as EGGS is EGGS on Sunday 5. Hard Cutlery 6. Swan's Regal Birdbath 7. Tetrahedron 8. Fairly Old Curtains 9. Swank 10. Globule, Follicle 11. Mum is your Dad (& your DAD is your MUM) 12. Mumma's Shoes 13. Hydraulic Legs 14. Milk and 2 Sugars 15. Coffee Tea? 16. Make it come out GREEN "Throw in a whiff of English whimsy here, Zappas lyrical madness and Sleepytime Gorilla Museum's convoluted addiction to time changes. A dose of noise and puerility there (and prodigious musical talent) and you have an album that surprises and confounds." - Sittingnow.co.uk "Sludge & Tripe" was recorded painstakingly between 2004 and 2008 in a number of derelict houses, basements and studios around London and Bristol, the collective's first album was then stitched together into a twisting, confronting DaDa-rock pronk-pop

In the course of modeling the naturally occurring tumor immunity seen in patients with paraneoplastic cerebellar degeneration (PCD), we discovered an unexpectedly high threshold for breaking CD8+ cytotoxic T cell (CTL) tolerance to the PCD autoantigen, CDR2. While CDR2 expression was previously found to be strictly restricted to immune-privileged cells (cerebellum, testes, and tumors), unexpectedly we have found that T cells also express CDR2. This expression underlies inhibition of CTL activation; CTLs that respond to epithelial cells expressing CDR2 fail to respond to T cells expressing CDR2. This was a general phenomenon, as T cells presenting influenza (flu) antigen also fail to activate otherwise potent flu-specific CTLs either in vitro or in vivo. Moreover, transfer of flu peptide-pulsed T cells into flu-infected mice inhibits endogenous flu-specific CTLs. Our finding that T cells serve as a site of immune privilege, inhibiting effector CTL function, uncovers an autorepressive loop with ...

In recent years, there has been a dramatic increase in the awareness of immunological encephalopathies in neuropsychiatry. Several case reports and case series have reported immunological encephalopathies mimicking dysexecutive, psychotic, depressive, and demential syndromes. Pathophysiologically, antineuronal antibodies against neuronal cell surface antigens (e.g., NMDAR-antibodies), against intracellular synaptic antigens (e.g., GAD-antibodies), and against intracellular onconeural antigens (e.g., Hu-antibodies) need to be distinguished. Moreover, thyroid autoantibodies (e.g., TPO-antibodies) could be associated with steroid responsive encephalopathy in patients with autoimmune thyroiditis (SREAT-syndrome). Epileptic and paraepileptic phenomena seem to play an important role in the clinical presentation of IEs. Therapeutic approaches with immunomodulatory treatment (e.g., corticosteroids, plasmapharesis) are promising, but clear therapeutical algorithms are still missing. Our ...

Is there any relationship between tumor hypoxia, a systemic hypercoaguable state, and tumor metastasis? With the introduction of the polarographic needle electrode, it is now possible for physicians to directly measure oxygen concentrations in the solid tumor. Recent investigations have demonstrated that solid tumors possess large regions with oxygen tension below 1-2 mm Hg. Several groups have used this technology to prospectively stratify patients based on tumor hypoxia and to correlate low tumor oxygen levels with increased local invasion, increased distant metastasis, and poor prognosis (9, 10, 11) . However, none have related changes in tumor oxygenation and the secretion of coagulation factors and fibrinolytic enzymes.. Regulation of plasmin has been identified in a number of experimental models as important in determining the invasive nature of tumor cells. Tumor models have established a role for hypoxia-responsive uPA/uPAR expression in the binding of tumor cells to the extracellular ...

Another name for Acanthosis Nigricans is Acanthosis Nigricans. Risk factors for acanthosis nigricans include: * Lymphoma * Oral contraceptives * Obesity ...

Acanthosis nigricans este de obicei asociat cu rezistenţa la insulină, diabetul zaharat, obezitatea, tumorile maligne, tul-bu-rările endocrine şi cu reacţiile medicamentoase. Trata-men-tul trebuie îndreptat asupra afecţiunii care stă la baza apariţiei acanthosis nigricans. Deşi conduita terapeutică principală este reprezentată de tratamentul cauzei primare, nu trebuie omise leziunile cutanate, acestea având un impact important asupra calităţii vieţii. Revizuirea ac-tua-lă pune în evidenţă eficacitatea terapiilor actuale ale acanthosis nigricans.